SF3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.28792618
2DNA unwinding involved in DNA replication (GO:0006268)4.57160297
3heterochromatin organization (GO:0070828)4.38513887
4negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.36258986
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.34669175
6protein localization to kinetochore (GO:0034501)4.22394016
7regulation of translational fidelity (GO:0006450)4.18682148
8pre-miRNA processing (GO:0031054)4.01031198
9formation of translation preinitiation complex (GO:0001731)3.93855368
10negative regulation of RNA splicing (GO:0033119)3.84532668
11mitotic sister chromatid segregation (GO:0000070)3.82907417
12dosage compensation (GO:0007549)3.72655810
13negative regulation of mRNA processing (GO:0050686)3.70583766
14folic acid-containing compound biosynthetic process (GO:0009396)3.69278467
15regulation of NFAT protein import into nucleus (GO:0051532)3.67353861
16DNA strand elongation involved in DNA replication (GO:0006271)3.66447169
17intracellular estrogen receptor signaling pathway (GO:0030520)3.64885377
18mitotic nuclear envelope disassembly (GO:0007077)3.55800166
19negative regulation of cell size (GO:0045792)3.52773330
20histone H4-K12 acetylation (GO:0043983)3.50965565
21peptidyl-arginine omega-N-methylation (GO:0035247)3.50417947
22protein localization to chromosome, centromeric region (GO:0071459)3.46416862
23establishment of apical/basal cell polarity (GO:0035089)3.45646906
24sister chromatid segregation (GO:0000819)3.45000981
25maternal placenta development (GO:0001893)3.44106690
26DNA strand elongation (GO:0022616)3.43356065
27negative regulation of mRNA metabolic process (GO:1903312)3.37936849
28regulation of gene silencing by RNA (GO:0060966)3.37092326
29regulation of posttranscriptional gene silencing (GO:0060147)3.37092326
30regulation of gene silencing by miRNA (GO:0060964)3.37092326
313-UTR-mediated mRNA stabilization (GO:0070935)3.36626468
32telomere maintenance via semi-conservative replication (GO:0032201)3.34677040
33RNA stabilization (GO:0043489)3.34264303
34mRNA stabilization (GO:0048255)3.34264303
35DNA duplex unwinding (GO:0032508)3.33416041
36modulation by virus of host process (GO:0019054)3.33202266
37DNA replication initiation (GO:0006270)3.33188128
38DNA geometric change (GO:0032392)3.29610438
39regulation of early endosome to late endosome transport (GO:2000641)3.28716127
40lymph vessel development (GO:0001945)3.28182812
41nuclear envelope disassembly (GO:0051081)3.27988828
42membrane disassembly (GO:0030397)3.27988828
43planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27635438
44trophectodermal cell differentiation (GO:0001829)3.25131621
45DNA deamination (GO:0045006)3.24468822
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.24098969
47DNA replication-dependent nucleosome organization (GO:0034723)3.23351256
48DNA replication-dependent nucleosome assembly (GO:0006335)3.23351256
49thymic T cell selection (GO:0045061)3.21937490
50apoptotic process involved in morphogenesis (GO:0060561)3.21707918
51chromatin assembly (GO:0031497)3.17115400
52IMP biosynthetic process (GO:0006188)3.15040457
53regulation of histone H3-K27 methylation (GO:0061085)3.14122660
54viral transcription (GO:0019083)3.12704038
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12195021
56mitotic G1 DNA damage checkpoint (GO:0031571)3.11134992
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08223318
58nuclear pore organization (GO:0006999)3.07292989
59proline biosynthetic process (GO:0006561)3.06368944
60regulation of RNA export from nucleus (GO:0046831)3.06038065
61modulation by symbiont of host cellular process (GO:0044068)3.04880711
62histone arginine methylation (GO:0034969)3.04508684
63protein retention in ER lumen (GO:0006621)3.04383351
64regulation of protein heterodimerization activity (GO:0043497)3.01146953
65nuclear pore complex assembly (GO:0051292)3.00910964
66positive thymic T cell selection (GO:0045059)3.00249549
67activation of Rac GTPase activity (GO:0032863)2.99816259
68translational termination (GO:0006415)2.98279933
69regulation of translational termination (GO:0006449)2.98202969
70adherens junction assembly (GO:0034333)2.95598161
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95253404
72peptidyl-arginine N-methylation (GO:0035246)2.94784779
73peptidyl-arginine methylation (GO:0018216)2.94784779
74positive regulation of histone deacetylation (GO:0031065)2.92141767
75mannose metabolic process (GO:0006013)2.91867427
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88478437
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88092705
78activation of MAPKKK activity (GO:0000185)2.88085976
79DNA replication checkpoint (GO:0000076)2.87737797
80protein-DNA complex disassembly (GO:0032986)2.87643747
81nucleosome disassembly (GO:0006337)2.87643747
82regulation of chromatin binding (GO:0035561)2.86962249
83Golgi transport vesicle coating (GO:0048200)2.85978354
84COPI coating of Golgi vesicle (GO:0048205)2.85978354
85translational initiation (GO:0006413)2.85189040
86positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83155660
87NIK/NF-kappaB signaling (GO:0038061)2.82079196
88translational elongation (GO:0006414)2.79931072
89ribosome biogenesis (GO:0042254)2.79712845
90negative regulation of histone methylation (GO:0031061)2.79711369
91termination of RNA polymerase II transcription (GO:0006369)2.78279389
92negative regulation of myotube differentiation (GO:0010832)2.78059482
93nuclear envelope organization (GO:0006998)2.77467655
94base-excision repair (GO:0006284)2.77440918
95establishment of monopolar cell polarity (GO:0061162)2.77425274
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.77425274
97regulation of nucleobase-containing compound transport (GO:0032239)2.77424192
98apoptotic process involved in development (GO:1902742)2.76604131
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76138282
100mitochondrial DNA metabolic process (GO:0032042)2.76032879
101DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.73634796
102histone H4 deacetylation (GO:0070933)2.73415112
103embryonic process involved in female pregnancy (GO:0060136)2.72634895
104antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72520696
105antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72346886
106ribosomal small subunit biogenesis (GO:0042274)2.71705304
107positive regulation of SMAD protein import into nucleus (GO:0060391)2.71584064
108mitotic G1/S transition checkpoint (GO:0044819)2.71143639
109regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70349238
110telomere maintenance via recombination (GO:0000722)2.69975148
111* mRNA splicing, via spliceosome (GO:0000398)2.69361200
112* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.69361200
113maturation of SSU-rRNA (GO:0030490)2.68789180
114* RNA splicing, via transesterification reactions (GO:0000375)2.68753848
115negative regulation of viral release from host cell (GO:1902187)2.66949478
116IMP metabolic process (GO:0046040)2.66041820
117snRNA metabolic process (GO:0016073)2.65506200
118cell-substrate adherens junction assembly (GO:0007045)2.64833963
119focal adhesion assembly (GO:0048041)2.64833963
120pentose-phosphate shunt (GO:0006098)2.64640853
121glucocorticoid receptor signaling pathway (GO:0042921)2.63817687
122chromosome condensation (GO:0030261)2.63510775
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63025607
124mitotic nuclear envelope reassembly (GO:0007084)2.62380893
125nuclear envelope reassembly (GO:0031468)2.62380893
126transcription from mitochondrial promoter (GO:0006390)2.61908776
127positive regulation of chromosome segregation (GO:0051984)2.61649853
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.61580117
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.60882757
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60882757
131mRNA cleavage (GO:0006379)2.60623845
132histone H3 deacetylation (GO:0070932)2.60477069
133positive regulation of gene expression, epigenetic (GO:0045815)2.60269348
134antigen processing and presentation via MHC class Ib (GO:0002475)2.60178904
135mucosal-associated lymphoid tissue development (GO:0048537)2.60036233
136Peyers patch development (GO:0048541)2.60036233
137mitotic recombination (GO:0006312)2.57738916
138regulation of monocyte differentiation (GO:0045655)2.57364091
139cellular response to virus (GO:0098586)2.56974250
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56856007
141cellular hyperosmotic response (GO:0071474)2.56211129
142DNA conformation change (GO:0071103)2.56141509
143regulation of stem cell maintenance (GO:2000036)2.55435503
144telomere maintenance via telomere lengthening (GO:0010833)2.55405986
145regulation of glucose import in response to insulin stimulus (GO:2001273)2.55146266
146antigen processing and presentation of endogenous antigen (GO:0019883)2.54296197
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.53835355
148positive regulation of protein deacetylation (GO:0090312)2.53666938
149mRNA transport (GO:0051028)2.53239440
150DNA damage response, signal transduction resulting in transcription (GO:0042772)2.52181262
151mitotic chromosome condensation (GO:0007076)2.51936741
152response to muramyl dipeptide (GO:0032495)2.51618810
153poly(A)+ mRNA export from nucleus (GO:0016973)2.51489383
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50597512
155regulation of integrin activation (GO:0033623)2.50376322
156negative regulation of striated muscle cell differentiation (GO:0051154)2.50248889
157response to laminar fluid shear stress (GO:0034616)2.46040333
158positive regulation of myotube differentiation (GO:0010831)2.45971754
159regulation of ARF GTPase activity (GO:0032312)2.44179976
160cellular response to interleukin-4 (GO:0071353)2.42710432
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40589348
162regulation of mRNA stability (GO:0043488)2.36817984
163cell-cell junction maintenance (GO:0045217)2.36686542
164modulation by virus of host morphology or physiology (GO:0019048)2.36348308
165protein export from nucleus (GO:0006611)2.34176517
166regulation of RNA stability (GO:0043487)2.34017033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17169109
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.68134757
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43712914
4MYC_22102868_ChIP-Seq_BL_Human3.40615894
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.94952729
6VDR_21846776_ChIP-Seq_THP-1_Human2.46254645
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.39815986
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33878527
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33008630
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32865076
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26846278
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20157552
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99926192
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96625732
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94090195
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89795857
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87365121
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85670306
19XRN2_22483619_ChIP-Seq_HELA_Human1.84348849
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.78987757
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75755440
22TCF7_22412390_ChIP-Seq_EML_Mouse1.73574362
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69490653
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.69053921
25KDM2B_26808549_Chip-Seq_K562_Human1.65672817
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.64849132
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64209973
28KDM2B_26808549_Chip-Seq_DND41_Human1.62544926
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60269648
30CIITA_25753668_ChIP-Seq_RAJI_Human1.57606594
31SA1_27219007_Chip-Seq_ERYTHROID_Human1.56522042
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.55354584
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55286752
34* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54885670
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54140789
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53866403
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53866403
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53866403
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53622435
40LXR_22292898_ChIP-Seq_THP-1_Human1.50901675
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50778732
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47915839
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47409454
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46574779
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46143440
46* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46128253
47MAF_26560356_Chip-Seq_TH1_Human1.45383538
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.44565171
49UTX_26944678_Chip-Seq_JUKART_Human1.43839920
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42760275
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42393811
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.39398312
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38447324
54* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37077007
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36128177
56KDM5A_27292631_Chip-Seq_BREAST_Human1.35714541
57CREB1_26743006_Chip-Seq_LNCaP_Human1.34452243
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34201391
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.34072679
60SMC4_20622854_ChIP-Seq_HELA_Human1.33346950
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33004196
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32071932
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31405126
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30517181
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29550101
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27886172
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.26405905
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25586482
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25122604
70GABP_19822575_ChIP-Seq_HepG2_Human1.23704568
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22892439
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19947595
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.19782028
74RACK7_27058665_Chip-Seq_MCF-7_Human1.18560224
75MAF_26560356_Chip-Seq_TH2_Human1.18395463
76* BCOR_27268052_Chip-Seq_Bcells_Human1.18110311
77* BCL6_27268052_Chip-Seq_Bcells_Human1.17125068
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16100604
79* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15764931
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15554210
81* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15481179
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15033478
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14742309
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13874911
85TTF2_22483619_ChIP-Seq_HELA_Human1.13651019
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13424817
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13126708
88DCP1A_22483619_ChIP-Seq_HELA_Human1.12946381
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12911476
90VDR_24763502_ChIP-Seq_THP-1_Human1.12874956
91SCL_19346495_ChIP-Seq_HPC-7_Human1.11554751
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.11529048
93ATF3_27146783_Chip-Seq_COLON_Human1.11457633
94* NCOR1_26117541_ChIP-Seq_K562_Human1.10948016
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10773067
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10666932
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09943902
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09915868
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09658745
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09423638
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.09412540
102FOXP3_21729870_ChIP-Seq_TREG_Human1.08653949
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08641867
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08498368
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08467160
106TFEB_21752829_ChIP-Seq_HELA_Human1.08442622
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08048889
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07981425
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07399270
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07059418
111AR_21909140_ChIP-Seq_LNCAP_Human1.06785290
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06410321
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06320780
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.05776098
115P68_20966046_ChIP-Seq_HELA_Human1.04993675
116ZNF263_19887448_ChIP-Seq_K562_Human1.04617440
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.03954520
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03893173
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.03631420
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02899631
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02462619
122PHF8_20622854_ChIP-Seq_HELA_Human1.02398770
123CTCF_27219007_Chip-Seq_Bcells_Human1.02082635
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01997511
125TP53_22127205_ChIP-Seq_IMR90_Human1.01744172
126* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01667620
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01246598
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01225996
129STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01173571
130CTCF_21964334_Chip-Seq_Bcells_Human1.01042382
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00474615
132VDR_23849224_ChIP-Seq_CD4+_Human1.00463417
133* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99781859
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99649714
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.98745139
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97957357
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97342099
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96301192
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96042956
140MYB_26560356_Chip-Seq_TH1_Human0.95837536
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95809843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.17971899
2MP0008057_abnormal_DNA_replication3.12807520
3MP0004957_abnormal_blastocyst_morpholog3.03114767
4MP0010352_gastrointestinal_tract_polyps3.02811180
5MP0003693_abnormal_embryo_hatching2.79218791
6MP0010094_abnormal_chromosome_stability2.74214270
7MP0003705_abnormal_hypodermis_morpholog2.73848496
8MP0009278_abnormal_bone_marrow2.65370358
9MP0003077_abnormal_cell_cycle2.61342563
10MP0005451_abnormal_body_composition2.57239210
11MP0005076_abnormal_cell_differentiation2.57013892
12MP0004858_abnormal_nervous_system2.56065738
13MP0010030_abnormal_orbit_morphology2.50554389
14MP0002396_abnormal_hematopoietic_system2.35620354
15MP0002653_abnormal_ependyma_morphology2.09871236
16MP0000350_abnormal_cell_proliferation2.06855814
17MP0001730_embryonic_growth_arrest2.05895761
18MP0005058_abnormal_lysosome_morphology2.00463568
19MP0005623_abnormal_meninges_morphology2.00043705
20MP0005397_hematopoietic_system_phenotyp1.99631442
21MP0001545_abnormal_hematopoietic_system1.99631442
22MP0000490_abnormal_crypts_of1.83702175
23MP0010307_abnormal_tumor_latency1.82457922
24MP0005380_embryogenesis_phenotype1.79462348
25MP0001672_abnormal_embryogenesis/_devel1.79462348
26MP0004197_abnormal_fetal_growth/weight/1.78658529
27MP0001697_abnormal_embryo_size1.73518824
28MP0003984_embryonic_growth_retardation1.70772414
29MP0008260_abnormal_autophagy1.68640657
30MP0002085_abnormal_embryonic_tissue1.68553135
31MP0002086_abnormal_extraembryonic_tissu1.68153585
32MP0002088_abnormal_embryonic_growth/wei1.68042520
33MP0002084_abnormal_developmental_patter1.67083740
34MP0008007_abnormal_cellular_replicative1.60393764
35MP0005666_abnormal_adipose_tissue1.56316802
36MP0002080_prenatal_lethality1.54657508
37MP0008932_abnormal_embryonic_tissue1.53087920
38MP0004808_abnormal_hematopoietic_stem1.52464522
39MP0000685_abnormal_immune_system1.49064165
40MP0009333_abnormal_splenocyte_physiolog1.46588870
41MP0008058_abnormal_DNA_repair1.45176893
42MP0000703_abnormal_thymus_morphology1.44513609
43MP0003172_abnormal_lysosome_physiology1.42699486
44MP0001873_stomach_inflammation1.41204613
45MP0001849_ear_inflammation1.40342870
46MP0005023_abnormal_wound_healing1.38330421
47MP0003566_abnormal_cell_adhesion1.37176964
48MP0002398_abnormal_bone_marrow1.36979471
49MP0005375_adipose_tissue_phenotype1.36512278
50MP0003763_abnormal_thymus_physiology1.35865434
51MP0000313_abnormal_cell_death1.35625180
52MP0002019_abnormal_tumor_incidence1.34976150
53MP0000003_abnormal_adipose_tissue1.32643599
54MP0003303_peritoneal_inflammation1.30459296
55MP0000681_abnormal_thyroid_gland1.30376386
56MP0002722_abnormal_immune_system1.29588036
57MP0001346_abnormal_lacrimal_gland1.28088077
58MP0004233_abnormal_muscle_weight1.27409420
59MP0001293_anophthalmia1.26606928
60MP0005409_darkened_coat_color1.26243888
61MP0003119_abnormal_digestive_system1.25961871
62MP0003786_premature_aging1.25515616
63MP0003300_gastrointestinal_ulcer1.25473459
64MP0003890_abnormal_embryonic-extraembry1.25458462
65MP0003123_paternal_imprinting1.24486171
66MP0002089_abnormal_postnatal_growth/wei1.22862457
67MP0000689_abnormal_spleen_morphology1.22109257
68MP0000537_abnormal_urethra_morphology1.18517818
69MP0004133_heterotaxia1.16152180
70MP0005670_abnormal_white_adipose1.16013853
71MP0002796_impaired_skin_barrier1.15359729
72MP0008961_abnormal_basal_metabolism1.13385598
73MP0002405_respiratory_system_inflammati1.11470995
74MP0000733_abnormal_muscle_development1.11071603
75MP0003091_abnormal_cell_migration1.07540114
76MP0008770_decreased_survivor_rate1.03437764
77MP0001915_intracranial_hemorrhage1.02569384
78MP0003283_abnormal_digestive_organ1.02419643
79MP0002429_abnormal_blood_cell1.00219700
80MP0003567_abnormal_fetal_cardiomyocyte0.97810649
81MP0002925_abnormal_cardiovascular_devel0.97041613
82MP0002932_abnormal_joint_morphology0.95291624
83MP0000858_altered_metastatic_potential0.94809590
84MP0004264_abnormal_extraembryonic_tissu0.94533181
85MP0005000_abnormal_immune_tolerance0.94527134
86MP0009931_abnormal_skin_appearance0.92943709
87MP0000750_abnormal_muscle_regeneration0.92211610
88MP0002420_abnormal_adaptive_immunity0.92190675
89MP0009840_abnormal_foam_cell0.91931069
90MP0002092_abnormal_eye_morphology0.91756037
91MP0009053_abnormal_anal_canal0.91329564
92MP0001819_abnormal_immune_cell0.90962119
93MP0005025_abnormal_response_to0.90439278
94MP0000428_abnormal_craniofacial_morphol0.90355971
95MP0000716_abnormal_immune_system0.89137961
96MP0002132_abnormal_respiratory_system0.88611691
97MP0002111_abnormal_tail_morphology0.86594997
98MP0002269_muscular_atrophy0.84926741
99MP0001800_abnormal_humoral_immune0.84514635
100MP0000477_abnormal_intestine_morphology0.84248869
101MP0001835_abnormal_antigen_presentation0.84187014
102MP0002970_abnormal_white_adipose0.82800273
103MP0002249_abnormal_larynx_morphology0.81686746
104MP0003453_abnormal_keratinocyte_physiol0.81423975
105MP0002723_abnormal_immune_serum0.81366826
106MP0003279_aneurysm0.80621174
107MP0005387_immune_system_phenotype0.80592627
108MP0001790_abnormal_immune_system0.80592627
109MP0000759_abnormal_skeletal_muscle0.80249624
110MP0009703_decreased_birth_body0.79407591
111MP0000266_abnormal_heart_morphology0.79331740
112MP0000678_abnormal_parathyroid_gland0.78754327
113MP0005464_abnormal_platelet_physiology0.78591337
114MP0002877_abnormal_melanocyte_morpholog0.78484682
115MP0004510_myositis0.78477720
116MP0001348_abnormal_lacrimal_gland0.77130599
117MP0010630_abnormal_cardiac_muscle0.76958347
118MP0005075_abnormal_melanosome_morpholog0.75950527
119MP0003115_abnormal_respiratory_system0.75920782
120MP0002452_abnormal_antigen_presenting0.75670963
121MP0004381_abnormal_hair_follicle0.75415201
122MP0009672_abnormal_birth_weight0.75348508
123MP0005621_abnormal_cell_physiology0.73942677
124MP0003942_abnormal_urinary_system0.73757564
125MP0006082_CNS_inflammation0.73322352
126MP0002697_abnormal_eye_size0.72780703
127MP0003448_altered_tumor_morphology0.72176709
128MP0003436_decreased_susceptibility_to0.71315345
129MP0004185_abnormal_adipocyte_glucose0.71050135
130MP0005501_abnormal_skin_physiology0.70711892
131MP0003121_genomic_imprinting0.70424600
132MP0000358_abnormal_cell_content/0.69456972
133MP0004947_skin_inflammation0.69143471
134MP0005384_cellular_phenotype0.68858128
135MP0010155_abnormal_intestine_physiology0.68099857

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.65770420
2Selective tooth agenesis (HP:0001592)3.50380007
3Hyperacusis (HP:0010780)3.08970245
4Rib fusion (HP:0000902)3.06514029
5Obstructive sleep apnea (HP:0002870)3.05171057
6Broad face (HP:0000283)2.95687897
7Basal cell carcinoma (HP:0002671)2.92943946
8Disproportionate tall stature (HP:0001519)2.89875372
9Long palpebral fissure (HP:0000637)2.86040429
10Increased density of long bones (HP:0006392)2.76101864
11Ulnar bowing (HP:0003031)2.74639619
12Broad distal phalanx of finger (HP:0009836)2.73963475
13Renal duplication (HP:0000075)2.70456436
14Truncus arteriosus (HP:0001660)2.70013475
15Astrocytoma (HP:0009592)2.65715285
16Abnormality of the astrocytes (HP:0100707)2.65715285
17Abnormality of the lower motor neuron (HP:0002366)2.59414376
18Cellulitis (HP:0100658)2.55031027
19Abnormal number of incisors (HP:0011064)2.54395270
20Abnormality of cells of the erythroid lineage (HP:0012130)2.52976080
21Hypertensive crisis (HP:0100735)2.52881654
22Abnormal number of erythroid precursors (HP:0012131)2.52315870
23Degeneration of anterior horn cells (HP:0002398)2.48809282
24Abnormality of the anterior horn cell (HP:0006802)2.48809282
25Deep palmar crease (HP:0006191)2.43049890
26Trismus (HP:0000211)2.42908297
27Broad palm (HP:0001169)2.41740553
28Stridor (HP:0010307)2.37794371
29Cerebral aneurysm (HP:0004944)2.37042321
30Short 5th finger (HP:0009237)2.37030707
31Distal lower limb amyotrophy (HP:0008944)2.36183727
32Hyperthyroidism (HP:0000836)2.35226596
33Skin tags (HP:0010609)2.35118173
34Neoplasm of striated muscle (HP:0009728)2.33772105
35Cholecystitis (HP:0001082)2.32135225
36Abnormal gallbladder physiology (HP:0012438)2.32135225
37Patellar aplasia (HP:0006443)2.30676713
38Increased nuchal translucency (HP:0010880)2.30500711
39Abnormality of the aortic arch (HP:0012303)2.29763478
40Pseudobulbar signs (HP:0002200)2.28268437
41Multiple enchondromatosis (HP:0005701)2.28055769
42Preauricular skin tag (HP:0000384)2.24448818
43Abnormality of the Achilles tendon (HP:0005109)2.20830961
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20561769
45Short 4th metacarpal (HP:0010044)2.20561769
46Medulloblastoma (HP:0002885)2.17985876
47Protrusio acetabuli (HP:0003179)2.17539577
48Hypochromic anemia (HP:0001931)2.17305342
49Increased IgE level (HP:0003212)2.16908760
50Annular pancreas (HP:0001734)2.16730681
51Spinal muscular atrophy (HP:0007269)2.15489978
52Reticulocytosis (HP:0001923)2.14802942
53Patellar dislocation (HP:0002999)2.14219512
54Myopathic facies (HP:0002058)2.13970337
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.13193896
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.12312289
57Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.12119287
58Biconcave vertebral bodies (HP:0004586)2.11891943
59Emphysema (HP:0002097)2.10976589
60Abnormality of reticulocytes (HP:0004312)2.10799076
61Aplasia/Hypoplasia of the patella (HP:0006498)2.10324281
62Rhabdomyosarcoma (HP:0002859)2.09615258
63Obstructive lung disease (HP:0006536)2.09494314
64Chronic obstructive pulmonary disease (HP:0006510)2.09494314
65Aplasia/hypoplasia of the humerus (HP:0006507)2.09265718
66Breast hypoplasia (HP:0003187)2.09109360
67Hand muscle atrophy (HP:0009130)2.08147406
68Pointed chin (HP:0000307)2.08068943
69Metaphyseal cupping (HP:0003021)2.06735869
70Abnormality of the distal phalanx of the thumb (HP:0009617)2.05752802
71Intestinal fistula (HP:0100819)2.05729360
72Genu recurvatum (HP:0002816)2.05317158
73Abnormality of the thoracic spine (HP:0100711)2.05280614
74Short humerus (HP:0005792)2.04808699
75Bowel incontinence (HP:0002607)2.04564734
76Seborrheic dermatitis (HP:0001051)2.04196904
77Reticulocytopenia (HP:0001896)2.03681094
78Increased connective tissue (HP:0009025)2.03077701
79Upper limb amyotrophy (HP:0009129)2.01981249
80Distal upper limb amyotrophy (HP:0007149)2.01981249
81Abnormality of the phalanges of the hallux (HP:0010057)2.01200286
82Thin ribs (HP:0000883)2.00082537
83Absent thumb (HP:0009777)1.99959265
84Poikiloderma (HP:0001029)1.99318563
85Vertebral fusion (HP:0002948)1.99096694
86Deviation of the thumb (HP:0009603)1.97190487
87Urethral obstruction (HP:0000796)1.97101177
88Proximal placement of thumb (HP:0009623)1.96926387
89Adenoma sebaceum (HP:0009720)1.96795738
90Angiofibromas (HP:0010615)1.96795738
91Facial hemangioma (HP:0000329)1.96405691
92Abnormality of the columella (HP:0009929)1.95981844
93Missing ribs (HP:0000921)1.95729284
94Nasal polyposis (HP:0100582)1.95582662
95Neoplasm of the oral cavity (HP:0100649)1.95103717
96Prominent nose (HP:0000448)1.94959829
97Atelectasis (HP:0100750)1.94586554
98Eczematoid dermatitis (HP:0000976)1.94387812
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93882193
100Gastrointestinal inflammation (HP:0004386)1.92681191
101Glioma (HP:0009733)1.92523993
102Abnormal large intestine physiology (HP:0012700)1.92470510
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91897077
104Gastrointestinal stroma tumor (HP:0100723)1.91318934
105Abnormality of the fingertips (HP:0001211)1.91007768
106Pustule (HP:0200039)1.90733380
107Easy fatigability (HP:0003388)1.89788062
108Colitis (HP:0002583)1.89240314
109Dysmetric saccades (HP:0000641)1.87774895
110High pitched voice (HP:0001620)1.86947440
111Absent radius (HP:0003974)1.86880280
112Muscle fibrillation (HP:0010546)1.85536896
113Unilateral renal agenesis (HP:0000122)1.84647231
114Thin bony cortex (HP:0002753)1.84472129
115Squamous cell carcinoma (HP:0002860)1.84361811
116Dislocated radial head (HP:0003083)1.84069509
117Segmental peripheral demyelination/remyelination (HP:0003481)1.83132276
118Carpal bone hypoplasia (HP:0001498)1.82759617
119Trigonocephaly (HP:0000243)1.82348919
120Insomnia (HP:0100785)1.81426187
121Polygenic inheritance (HP:0010982)1.80234035
122Tongue fasciculations (HP:0001308)1.80043065
123Rectal prolapse (HP:0002035)1.79217398
124Rectal fistula (HP:0100590)1.79147008
125Rectovaginal fistula (HP:0000143)1.79147008
126Premature skin wrinkling (HP:0100678)1.78660274
127Atresia of the external auditory canal (HP:0000413)1.78541386
128Turricephaly (HP:0000262)1.78477753
129Thoracic kyphosis (HP:0002942)1.76478778
130Progressive muscle weakness (HP:0003323)1.76426910
131Broad thumb (HP:0011304)1.76133284
132Cafe-au-lait spot (HP:0000957)1.75690044
133Bowing of the arm (HP:0006488)1.75485727
134Bowed forearm bones (HP:0003956)1.75485727
135Hemorrhage of the eye (HP:0011885)1.74055381
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.73987734
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73618507
138Abnormality of the nasal mucosa (HP:0000433)1.73184701
139Aplasia involving forearm bones (HP:0009822)1.72174786
140Absent forearm bone (HP:0003953)1.72174786
141Long eyelashes (HP:0000527)1.72152753
142Abnormality of the motor neurons (HP:0002450)1.71538805
143Abnormal neuron morphology (HP:0012757)1.71538805
144Overlapping toe (HP:0001845)1.70387438
145Hypercortisolism (HP:0001578)1.70008664
146Abnormality of the radial head (HP:0003995)1.69451016
147Polycythemia (HP:0001901)1.69362193
148Shallow orbits (HP:0000586)1.68628123
149Pallor (HP:0000980)1.68400554
150Nonimmune hydrops fetalis (HP:0001790)1.67846557
151Vertebral compression fractures (HP:0002953)1.67177553
152Mitral regurgitation (HP:0001653)1.64127400
153Fragile skin (HP:0001030)1.64082614
154Flat acetabular roof (HP:0003180)1.63814932
155Vaginal fistula (HP:0004320)1.62634117
156Abnormality of the 4th metacarpal (HP:0010012)1.62574677
157IgM deficiency (HP:0002850)1.62453248
158Petechiae (HP:0000967)1.62381171
159J-shaped sella turcica (HP:0002680)1.62130433
160Abnormality of the labia minora (HP:0012880)1.61725136
161Congenital hip dislocation (HP:0001374)1.61651146
162Achilles tendon contracture (HP:0001771)1.61577864
163Vertebral hypoplasia (HP:0008417)1.61314614
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61314614
165Heterotopia (HP:0002282)1.61030675
166Premature rupture of membranes (HP:0001788)1.60919826
167Mesangial abnormality (HP:0001966)1.60742823
168Self-mutilation (HP:0000742)1.60572480
169Ankle contracture (HP:0006466)1.60281730
170Ragged-red muscle fibers (HP:0003200)1.59837729
171Lower limb amyotrophy (HP:0007210)1.59508483
172High anterior hairline (HP:0009890)1.57007059
173Increased variability in muscle fiber diameter (HP:0003557)1.56994011
174Abnormality of the calcaneus (HP:0008364)1.56936629
175Gastrointestinal dysmotility (HP:0002579)1.56178006
176Abnormality of the distal phalanges of the toes (HP:0010182)1.53139033
177Elfin facies (HP:0004428)1.52747002
178Flared metaphyses (HP:0003015)1.52452808
179Hypoparathyroidism (HP:0000829)1.51650912
180Germ cell neoplasia (HP:0100728)1.51436037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.34450115
2SMG14.11784594
3MAP3K103.94450402
4EEF2K3.54287498
5PRPF4B3.34900938
6TRIB33.24873771
7ICK3.03147059
8ERN12.79066721
9PKN22.44594448
10MAP4K12.37509719
11CDC72.24872369
12IRAK32.09195969
13NEK21.96927027
14TESK21.83351001
15STK101.81093875
16CDK71.80313625
17GRK61.76654920
18MAP3K111.72815442
19BMX1.66722149
20BUB11.54141759
21RPS6KB21.51486057
22PAK41.43306443
23CDK41.42625358
24FGFR41.38422342
25ALK1.34612920
26TYRO31.30433075
27MAP3K131.29706291
28MTOR1.28970947
29LRRK21.27389159
30TTK1.26960170
31WEE11.17932297
32SIK11.15307366
33NEK11.14887197
34TAOK11.12963339
35PDGFRA1.12422728
36PIM21.12135882
37RIPK41.10859610
38MATK1.09060422
39PRKD31.09040100
40TTN1.07259480
41BRD41.05493448
42TNK21.04846901
43MAP3K81.04101586
44BRAF1.04077130
45PIM11.03370313
46DDR21.00865308
47SIK31.00439552
48IRAK40.99753399
49KSR20.98414491
50SCYL20.98218841
51RPS6KA40.97508846
52PLK10.97385332
53CDK60.96331462
54ARAF0.96083337
55KDR0.92913526
56ATR0.92682250
57DYRK30.91593055
58CHEK20.90902736
59PASK0.90528845
60MAP3K10.90345019
61CHEK10.89996535
62PTK60.88021108
63DYRK1B0.87327724
64CSF1R0.86262367
65CDC42BPA0.85669058
66SIK20.85411951
67ZAP700.83681584
68VRK20.81936972
69CSK0.80490470
70RPS6KA20.77159846
71CDK20.74804343
72AURKB0.73791647
73MAPK110.73027141
74PAK20.72928462
75MAPKAPK30.72209494
76IRAK20.71199158
77AKT20.71171231
78TSSK60.70771302
79CAMK1D0.70092913
80EPHA20.69166570
81STK40.69122544
82MAP2K30.68677446
83LATS20.68147348
84PRKD20.67093312
85PDPK10.66872027
86UHMK10.66776890
87TBK10.66220923
88RIPK10.65989503
89BTK0.65488860
90CDK90.65394751
91AURKA0.65166315
92RPS6KA10.64864062
93TESK10.64296790
94EPHB10.63290915
95FLT30.62808850
96CHUK0.61888546
97RPS6KL10.61662112
98RPS6KC10.61662112
99HIPK20.60246806
100PAK10.59032062
101RPS6KA60.58150002
102NME20.57094611
103MAP3K140.56262322
104BLK0.55485259
105CAMKK10.53406315
106ILK0.52305262
107MAPKAPK20.52083791
108MAP3K70.50885262
109MAP3K60.50837174
110TAOK20.50237004
111ATM0.49780677
112BRSK10.49319619
113DAPK10.48030291
114MAP3K30.47522202
115TGFBR10.46754717
116JAK30.43945103
117PTK20.43904769
118MAPK120.43627806
119PDK10.42575022
120PRKG20.42303016
121CDK10.41910103
122EIF2AK10.40661271
123TGFBR20.40191502
124HCK0.38966466
125MAPK10.38348417
126MARK20.38028683
127MOS0.37812475
128TYK20.35942266
129CLK10.34625944
130FES0.34503930
131MAP2K20.34328530
132CDK11A0.33848049
133STK30.32520467

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99913643
2Mismatch repair_Homo sapiens_hsa034303.28209511
3Base excision repair_Homo sapiens_hsa034103.02830396
4* Spliceosome_Homo sapiens_hsa030402.84598914
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56643073
6RNA transport_Homo sapiens_hsa030132.56092561
7One carbon pool by folate_Homo sapiens_hsa006702.31368439
8Cell cycle_Homo sapiens_hsa041102.23461127
9Ribosome_Homo sapiens_hsa030102.19989962
10mRNA surveillance pathway_Homo sapiens_hsa030152.09346867
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91481598
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83946292
13Other glycan degradation_Homo sapiens_hsa005111.83857204
14Notch signaling pathway_Homo sapiens_hsa043301.80992474
15Nucleotide excision repair_Homo sapiens_hsa034201.80226899
16Homologous recombination_Homo sapiens_hsa034401.71119563
17Chronic myeloid leukemia_Homo sapiens_hsa052201.69230418
18p53 signaling pathway_Homo sapiens_hsa041151.47026837
19Acute myeloid leukemia_Homo sapiens_hsa052211.46248951
20Bladder cancer_Homo sapiens_hsa052191.43831882
21Primary immunodeficiency_Homo sapiens_hsa053401.40944327
22mTOR signaling pathway_Homo sapiens_hsa041501.34249007
23HTLV-I infection_Homo sapiens_hsa051661.30535913
24Sulfur relay system_Homo sapiens_hsa041221.27359840
25MicroRNAs in cancer_Homo sapiens_hsa052061.23074895
26Viral carcinogenesis_Homo sapiens_hsa052031.18903312
27Lysine degradation_Homo sapiens_hsa003101.18225053
28Prion diseases_Homo sapiens_hsa050201.17186356
29Fanconi anemia pathway_Homo sapiens_hsa034601.15703671
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15694169
31Small cell lung cancer_Homo sapiens_hsa052221.15421204
32Biosynthesis of amino acids_Homo sapiens_hsa012301.15319651
33Basal cell carcinoma_Homo sapiens_hsa052171.15292638
34RNA degradation_Homo sapiens_hsa030181.14989942
35Herpes simplex infection_Homo sapiens_hsa051681.14235541
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12386477
37Thyroid cancer_Homo sapiens_hsa052161.10111900
38Colorectal cancer_Homo sapiens_hsa052101.09729530
39Shigellosis_Homo sapiens_hsa051311.09672592
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08848343
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07834556
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07613122
43ErbB signaling pathway_Homo sapiens_hsa040121.07575692
44Antigen processing and presentation_Homo sapiens_hsa046121.06370969
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.05989944
46Pyrimidine metabolism_Homo sapiens_hsa002401.02394445
47Hippo signaling pathway_Homo sapiens_hsa043901.02348747
48B cell receptor signaling pathway_Homo sapiens_hsa046621.01766968
49Non-small cell lung cancer_Homo sapiens_hsa052231.01030005
50Epstein-Barr virus infection_Homo sapiens_hsa051690.99372088
51Apoptosis_Homo sapiens_hsa042100.97338732
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.95288501
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94925147
54Adherens junction_Homo sapiens_hsa045200.94786994
55RNA polymerase_Homo sapiens_hsa030200.93678167
56Viral myocarditis_Homo sapiens_hsa054160.93474591
57VEGF signaling pathway_Homo sapiens_hsa043700.92243912
58Pentose phosphate pathway_Homo sapiens_hsa000300.92231267
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91441621
60Hepatitis B_Homo sapiens_hsa051610.91296037
61Choline metabolism in cancer_Homo sapiens_hsa052310.87167055
62Pancreatic cancer_Homo sapiens_hsa052120.86261138
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85452674
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85038709
65Proteoglycans in cancer_Homo sapiens_hsa052050.83158966
66Hedgehog signaling pathway_Homo sapiens_hsa043400.82492729
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.81468993
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78481158
69Measles_Homo sapiens_hsa051620.77980644
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.75533135
71Fructose and mannose metabolism_Homo sapiens_hsa000510.75473198
72Prolactin signaling pathway_Homo sapiens_hsa049170.73718169
73TNF signaling pathway_Homo sapiens_hsa046680.73433338
74Legionellosis_Homo sapiens_hsa051340.72704634
75Hepatitis C_Homo sapiens_hsa051600.72600615
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71649459
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71637317
78GnRH signaling pathway_Homo sapiens_hsa049120.71311366
79HIF-1 signaling pathway_Homo sapiens_hsa040660.71189720
80T cell receptor signaling pathway_Homo sapiens_hsa046600.70550447
81Inositol phosphate metabolism_Homo sapiens_hsa005620.70342263
82Selenocompound metabolism_Homo sapiens_hsa004500.70272610
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68754844
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68449708
85Endocytosis_Homo sapiens_hsa041440.68180429
86Endometrial cancer_Homo sapiens_hsa052130.68022852
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67614420
88Leishmaniasis_Homo sapiens_hsa051400.67326339
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67294123
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66367810
91Pathways in cancer_Homo sapiens_hsa052000.65717881
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.65489095
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65452914
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.65032631
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64648411
96Estrogen signaling pathway_Homo sapiens_hsa049150.64492078
97Galactose metabolism_Homo sapiens_hsa000520.63750749
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61707968
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60481842
100Salmonella infection_Homo sapiens_hsa051320.59284282
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57736738
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57294293
103Non-homologous end-joining_Homo sapiens_hsa034500.57181446
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.56988176
105TGF-beta signaling pathway_Homo sapiens_hsa043500.56726601
106Tuberculosis_Homo sapiens_hsa051520.55708915
107Oocyte meiosis_Homo sapiens_hsa041140.54939386
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.53102461
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53078411
110MAPK signaling pathway_Homo sapiens_hsa040100.52886319
111Chemokine signaling pathway_Homo sapiens_hsa040620.51951773
112Focal adhesion_Homo sapiens_hsa045100.51486450
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50865879
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50746671
115Wnt signaling pathway_Homo sapiens_hsa043100.48996184
116Toxoplasmosis_Homo sapiens_hsa051450.48578740
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48257504
118FoxO signaling pathway_Homo sapiens_hsa040680.47729476
119AMPK signaling pathway_Homo sapiens_hsa041520.47238073
120Glioma_Homo sapiens_hsa052140.45601959
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44904113
122Osteoclast differentiation_Homo sapiens_hsa043800.44453931
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43308980
124Prostate cancer_Homo sapiens_hsa052150.43202713
125Influenza A_Homo sapiens_hsa051640.42512895
126Carbon metabolism_Homo sapiens_hsa012000.42429358
127Insulin signaling pathway_Homo sapiens_hsa049100.42153492
128Renal cell carcinoma_Homo sapiens_hsa052110.41369576
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.41323701

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