SEZ6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.99368883
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83257298
3vocalization behavior (GO:0071625)5.82268785
4locomotory exploration behavior (GO:0035641)5.69510416
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.64751213
6synaptic vesicle maturation (GO:0016188)5.55169420
7regulation of synapse structural plasticity (GO:0051823)5.29285657
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24922761
9regulation of glutamate receptor signaling pathway (GO:1900449)5.21700095
10protein localization to synapse (GO:0035418)5.08232711
11synaptic vesicle exocytosis (GO:0016079)5.03654212
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.89592451
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.84953782
14dendritic spine morphogenesis (GO:0060997)4.61910338
15neuron cell-cell adhesion (GO:0007158)4.61509018
16regulation of neuronal synaptic plasticity (GO:0048168)4.60251207
17regulation of synaptic vesicle exocytosis (GO:2000300)4.59768924
18behavioral response to nicotine (GO:0035095)4.58823083
19layer formation in cerebral cortex (GO:0021819)4.57429960
20exploration behavior (GO:0035640)4.53881692
21neurotransmitter-gated ion channel clustering (GO:0072578)4.52316880
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.40856656
23presynaptic membrane organization (GO:0097090)4.36728312
24glutamate secretion (GO:0014047)4.31500413
25synaptic transmission, glutamatergic (GO:0035249)4.31137565
26glutamate receptor signaling pathway (GO:0007215)4.28517077
27pyrimidine nucleobase catabolic process (GO:0006208)4.25298039
28prepulse inhibition (GO:0060134)4.23585511
29neurotransmitter secretion (GO:0007269)4.23145037
30regulation of dendritic spine morphogenesis (GO:0061001)4.21711669
31auditory behavior (GO:0031223)4.20910049
32neuron-neuron synaptic transmission (GO:0007270)4.20023998
33regulation of synaptic vesicle transport (GO:1902803)4.14824383
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12299344
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07515879
36positive regulation of synaptic transmission, GABAergic (GO:0032230)4.05500817
37long-term memory (GO:0007616)4.01994064
38gamma-aminobutyric acid transport (GO:0015812)4.00437287
39positive regulation of membrane potential (GO:0045838)3.99722627
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.98297988
41positive regulation of synapse maturation (GO:0090129)3.97224634
42neuronal action potential propagation (GO:0019227)3.94432538
43serotonin metabolic process (GO:0042428)3.90817131
44* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87534001
45response to auditory stimulus (GO:0010996)3.86933070
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82183882
47adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.78806693
48synaptic transmission, dopaminergic (GO:0001963)3.76626670
49striatum development (GO:0021756)3.74541811
50neuromuscular process controlling balance (GO:0050885)3.70993547
51neuron recognition (GO:0008038)3.70945802
52transmission of nerve impulse (GO:0019226)3.69732880
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.68426837
54dopamine receptor signaling pathway (GO:0007212)3.66699893
55regulation of synaptic plasticity (GO:0048167)3.64547894
56* regulation of postsynaptic membrane potential (GO:0060078)3.63546561
57regulation of female receptivity (GO:0045924)3.63283271
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.62831503
59positive regulation of neurotransmitter transport (GO:0051590)3.62711511
60positive regulation of neurotransmitter secretion (GO:0001956)3.61810399
61primary amino compound metabolic process (GO:1901160)3.60134471
62behavioral defense response (GO:0002209)3.58766474
63behavioral fear response (GO:0001662)3.58766474
64pharyngeal system development (GO:0060037)3.55650797
65nucleobase catabolic process (GO:0046113)3.55479381
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.54983031
67proline transport (GO:0015824)3.52530430
68postsynaptic membrane organization (GO:0001941)3.52300487
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.48158433
70axonal fasciculation (GO:0007413)3.44850190
71long-term synaptic potentiation (GO:0060291)3.44631491
72regulation of dendritic spine development (GO:0060998)3.43931993
73positive regulation of dendritic spine development (GO:0060999)3.43209451
74behavioral response to cocaine (GO:0048148)3.43029009
75neuronal ion channel clustering (GO:0045161)3.41137577
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38087178
77response to amphetamine (GO:0001975)3.36602312
78cellular potassium ion homeostasis (GO:0030007)3.36541388
79neurotransmitter transport (GO:0006836)3.36333033
80learning (GO:0007612)3.34762868
81dendritic spine organization (GO:0097061)3.33411827
82membrane depolarization during action potential (GO:0086010)3.30812148
83dendrite morphogenesis (GO:0048813)3.30063482
84mechanosensory behavior (GO:0007638)3.29917617
85synaptic vesicle endocytosis (GO:0048488)3.29383439
86membrane hyperpolarization (GO:0060081)3.28644968
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27065635
88regulation of neurotransmitter secretion (GO:0046928)3.26438747
89activation of protein kinase A activity (GO:0034199)3.26183760
90response to histamine (GO:0034776)3.25773831
91fear response (GO:0042596)3.25702531
92regulation of glutamate secretion (GO:0014048)3.25071145
93female mating behavior (GO:0060180)3.24062532
94outer ear morphogenesis (GO:0042473)3.21019370
95negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20221377
96regulation of neurotransmitter levels (GO:0001505)3.18111121
97regulation of vesicle fusion (GO:0031338)3.17958107
98gamma-aminobutyric acid signaling pathway (GO:0007214)3.13922051
99regulation of synaptic transmission, GABAergic (GO:0032228)3.13390286
100synapse assembly (GO:0007416)3.13385721
101regulation of neurotransmitter transport (GO:0051588)3.13377840
102regulation of synapse maturation (GO:0090128)3.11504022
103* membrane depolarization (GO:0051899)3.11232176
104presynaptic membrane assembly (GO:0097105)3.11164913
105sodium ion export (GO:0071436)3.10886095
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10467341
107negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10436481
108visual learning (GO:0008542)3.09586213
109C4-dicarboxylate transport (GO:0015740)3.09495087
110cell migration in hindbrain (GO:0021535)3.08829631
111regulation of action potential (GO:0098900)2.99171200
112regulation of cardioblast proliferation (GO:0003264)2.90078108
113regulation of secondary heart field cardioblast proliferation (GO:0003266)2.90078108
114neuromuscular synaptic transmission (GO:0007274)2.86837070
115neuronal action potential (GO:0019228)2.84706065
116indole-containing compound metabolic process (GO:0042430)2.84347583
117spinal cord development (GO:0021510)2.84215488
118neuromuscular process controlling posture (GO:0050884)2.81691929
119central nervous system projection neuron axonogenesis (GO:0021952)2.78541031
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.77816999
121potassium ion import (GO:0010107)2.77445325
122indolalkylamine metabolic process (GO:0006586)2.76415417
123limb bud formation (GO:0060174)2.76235622
124negative regulation of response to food (GO:0032096)2.72983774
125negative regulation of appetite (GO:0032099)2.72983774
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.71062730
127establishment of mitochondrion localization (GO:0051654)2.69410002
128action potential (GO:0001508)2.65580196
129positive regulation of meiosis (GO:0045836)2.62376958
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61773352
131glycosphingolipid biosynthetic process (GO:0006688)2.61666309
132cornea development in camera-type eye (GO:0061303)2.60046110
133adult walking behavior (GO:0007628)2.58269571
134positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58222718
135regulation of neurotransmitter uptake (GO:0051580)2.58107671
136detection of light stimulus involved in sensory perception (GO:0050962)2.53926521
137detection of light stimulus involved in visual perception (GO:0050908)2.53926521
138protein polyglutamylation (GO:0018095)2.53653389
139synaptic transmission (GO:0007268)2.53523216
140glycerophospholipid catabolic process (GO:0046475)2.52893816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29455934
2GBX2_23144817_ChIP-Seq_PC3_Human3.32059450
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.24839335
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22776764
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.10742614
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09170604
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.85900693
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82883429
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82883429
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80737136
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68749534
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68502157
13DROSHA_22980978_ChIP-Seq_HELA_Human2.64538826
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59874184
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57659907
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57193572
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57117626
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55060380
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45181773
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.45144834
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40673048
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35157660
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33349177
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.30732491
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29824728
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.26966744
27VDR_22108803_ChIP-Seq_LS180_Human2.18874925
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15231572
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13809629
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00160377
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90724238
32AR_21572438_ChIP-Seq_LNCaP_Human1.87158739
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.73969397
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73877124
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65881515
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58468728
37FUS_26573619_Chip-Seq_HEK293_Human1.51107100
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50095915
39TAF15_26573619_Chip-Seq_HEK293_Human1.49502532
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49397476
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.46571478
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.45449675
43SMAD4_21799915_ChIP-Seq_A2780_Human1.45290387
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44067700
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38119204
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36292953
47ZNF274_21170338_ChIP-Seq_K562_Hela1.35470647
48EWS_26573619_Chip-Seq_HEK293_Human1.34659078
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.34282443
50* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34009296
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31902093
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28497000
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27945411
54* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27650782
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.27330915
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27178656
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25941939
58CBP_20019798_ChIP-Seq_JUKART_Human1.25768436
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25768436
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25159282
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22991805
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22142107
63KDM2B_26808549_Chip-Seq_K562_Human1.20682555
64ER_23166858_ChIP-Seq_MCF-7_Human1.20215548
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19917784
66AR_19668381_ChIP-Seq_PC3_Human1.19643363
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19300645
68P300_19829295_ChIP-Seq_ESCs_Human1.18502894
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18361916
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18146765
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17331292
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17306614
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14616315
74BCAT_22108803_ChIP-Seq_LS180_Human1.13315303
75STAT3_23295773_ChIP-Seq_U87_Human1.12687227
76AR_25329375_ChIP-Seq_VCAP_Human1.12264383
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11838440
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11324118
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11143991
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10212889
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09821241
82RNF2_27304074_Chip-Seq_NSC_Mouse1.09445561
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09388920
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08670766
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.08297946
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07548856
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.04932880
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.04807883
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04418309
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03673408
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03206155
92IRF1_19129219_ChIP-ChIP_H3396_Human1.03012102
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02736179
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02296690
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.02178868
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.01465088
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00615214
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99539971
99* TP53_22573176_ChIP-Seq_HFKS_Human0.99457430
100P53_22387025_ChIP-Seq_ESCs_Mouse0.99077989
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98851418
102* TCF4_23295773_ChIP-Seq_U87_Human0.97996605
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97360957
104TCF4_22108803_ChIP-Seq_LS180_Human0.97275178
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.96742101
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96188879
107* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95689154
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95332453
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95261403
110* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95222617
111* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94894484
112CTCF_27219007_Chip-Seq_Bcells_Human0.94448521
113IGF1R_20145208_ChIP-Seq_DFB_Human0.94029460
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.93003783
115RUNX2_22187159_ChIP-Seq_PCA_Human0.92812774
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.91991971
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.91818195
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91479214
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90716451
120* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90335971
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.90262087
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89793462
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89793462
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89770160
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89598093
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86976760
127AHR_22903824_ChIP-Seq_MCF-7_Human0.86435954
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.85233337
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84564850
130* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82814491
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82462359
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.81852997
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81624170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61579483
2MP0002822_catalepsy4.84831192
3MP0003880_abnormal_central_pattern4.70529990
4* MP0003635_abnormal_synaptic_transmissio4.22395180
5MP0004270_analgesia3.58631549
6* MP0009745_abnormal_behavioral_response3.54360652
7* MP0002063_abnormal_learning/memory/cond3.52889744
8MP0005423_abnormal_somatic_nervous3.16058178
9* MP0002064_seizures3.04569177
10MP0002572_abnormal_emotion/affect_behav2.87871117
11MP0009046_muscle_twitch2.84491091
12MP0001968_abnormal_touch/_nociception2.78456249
13MP0001486_abnormal_startle_reflex2.70738635
14MP0002272_abnormal_nervous_system2.48024452
15MP0002734_abnormal_mechanical_nocicepti2.45290623
16MP0008877_abnormal_DNA_methylation2.42330898
17MP0001501_abnormal_sleep_pattern2.16267822
18MP0001529_abnormal_vocalization2.09977342
19MP0002736_abnormal_nociception_after2.03755841
20MP0000778_abnormal_nervous_system2.02204139
21MP0001440_abnormal_grooming_behavior1.98502069
22MP0002733_abnormal_thermal_nociception1.94413749
23MP0002909_abnormal_adrenal_gland1.93170780
24MP0001970_abnormal_pain_threshold1.89808702
25MP0002557_abnormal_social/conspecific_i1.89763323
26MP0002735_abnormal_chemical_nociception1.89077957
27MP0004811_abnormal_neuron_physiology1.85821294
28MP0008569_lethality_at_weaning1.83561701
29MP0002067_abnormal_sensory_capabilities1.83297350
30MP0004924_abnormal_behavior1.83008441
31MP0005386_behavior/neurological_phenoty1.83008441
32MP0005646_abnormal_pituitary_gland1.80032734
33MP0009780_abnormal_chondrocyte_physiolo1.79300331
34MP0001984_abnormal_olfaction1.77421365
35* MP0002184_abnormal_innervation1.74985627
36MP0003329_amyloid_beta_deposits1.60346300
37MP0001188_hyperpigmentation1.58504146
38MP0004858_abnormal_nervous_system1.57707266
39MP0000955_abnormal_spinal_cord1.56513741
40MP0003879_abnormal_hair_cell1.55758553
41MP0006276_abnormal_autonomic_nervous1.50647985
42MP0004885_abnormal_endolymph1.49171687
43MP0002102_abnormal_ear_morphology1.47696123
44MP0003121_genomic_imprinting1.47100047
45MP0002160_abnormal_reproductive_system1.43129713
46* MP0002882_abnormal_neuron_morphology1.43016108
47MP0002837_dystrophic_cardiac_calcinosis1.42386592
48* MP0002066_abnormal_motor_capabilities/c1.39470373
49MP0000678_abnormal_parathyroid_gland1.36962216
50MP0003787_abnormal_imprinting1.33632727
51MP0005409_darkened_coat_color1.31211291
52MP0001502_abnormal_circadian_rhythm1.26955039
53MP0000049_abnormal_middle_ear1.25949536
54MP0005645_abnormal_hypothalamus_physiol1.24251532
55MP0005253_abnormal_eye_physiology1.23961716
56MP0002152_abnormal_brain_morphology1.19501240
57MP0001905_abnormal_dopamine_level1.19355071
58MP0003633_abnormal_nervous_system1.18601734
59MP0005394_taste/olfaction_phenotype1.14064119
60MP0005499_abnormal_olfactory_system1.14064119
61MP0004142_abnormal_muscle_tone1.13202632
62MP0003938_abnormal_ear_development1.11910636
63MP0002249_abnormal_larynx_morphology1.11496907
64MP0001986_abnormal_taste_sensitivity1.08950632
65MP0002876_abnormal_thyroid_physiology1.07815976
66MP0000026_abnormal_inner_ear1.06050422
67MP0005551_abnormal_eye_electrophysiolog1.04550247
68MP0005389_reproductive_system_phenotype1.04380491
69MP0002069_abnormal_eating/drinking_beha1.03638440
70MP0001177_atelectasis1.03497432
71MP0008995_early_reproductive_senescence1.01446471
72MP0003123_paternal_imprinting1.00822376
73MP0004147_increased_porphyrin_level1.00394103
74MP0003631_nervous_system_phenotype1.00018667
75MP0008872_abnormal_physiological_respon0.99636048
76MP0003646_muscle_fatigue0.98853924
77MP0000631_abnormal_neuroendocrine_gland0.95773654
78MP0008874_decreased_physiological_sensi0.94511110
79MP0000569_abnormal_digit_pigmentation0.93305212
80MP0003283_abnormal_digestive_organ0.92549716
81MP0004133_heterotaxia0.91937989
82MP0003119_abnormal_digestive_system0.90756887
83MP0003075_altered_response_to0.89905010
84MP0004085_abnormal_heartbeat0.89740701
85MP0003195_calcinosis0.88865788
86MP0002229_neurodegeneration0.87341966
87MP0006292_abnormal_olfactory_placode0.85741355
88MP0008961_abnormal_basal_metabolism0.85462507
89MP0000681_abnormal_thyroid_gland0.85382617
90MP0003011_delayed_dark_adaptation0.84910971
91MP0000751_myopathy0.82735381
92MP0004742_abnormal_vestibular_system0.80729857
93MP0002090_abnormal_vision0.80546113
94MP0003634_abnormal_glial_cell0.80318345
95MP0005535_abnormal_body_temperature0.80086346
96MP0002752_abnormal_somatic_nervous0.79212511
97MP0003137_abnormal_impulse_conducting0.78294535
98MP0002751_abnormal_autonomic_nervous0.77553483
99MP0010386_abnormal_urinary_bladder0.76358163
100MP0002638_abnormal_pupillary_reflex0.75568495
101MP0003122_maternal_imprinting0.75206485
102MP0005195_abnormal_posterior_eye0.70685540
103MP0003861_abnormal_nervous_system0.69912074
104MP0005167_abnormal_blood-brain_barrier0.69607347
105MP0001963_abnormal_hearing_physiology0.69466005
106MP0000013_abnormal_adipose_tissue0.68139265
107MP0003632_abnormal_nervous_system0.67965234
108MP0003690_abnormal_glial_cell0.66971103
109MP0004130_abnormal_muscle_cell0.65650636
110MP0003698_abnormal_male_reproductive0.64531144
111MP0001664_abnormal_digestion0.64127158
112MP0000604_amyloidosis0.63356095
113MP0000920_abnormal_myelination0.62539228
114MP0001485_abnormal_pinna_reflex0.61854057
115MP0001943_abnormal_respiration0.57101680
116MP0004145_abnormal_muscle_electrophysio0.56554538
117MP0002653_abnormal_ependyma_morphology0.55680914
118MP0010769_abnormal_survival0.53990963
119MP0005187_abnormal_penis_morphology0.53930542
120MP0002234_abnormal_pharynx_morphology0.53844067
121MP0010234_abnormal_vibrissa_follicle0.52471928
122MP0010770_preweaning_lethality0.52446072
123MP0002082_postnatal_lethality0.52446072
124MP0006072_abnormal_retinal_apoptosis0.50834859
125MP0010768_mortality/aging0.50759098
126MP0003956_abnormal_body_size0.49583168
127MP0004215_abnormal_myocardial_fiber0.48696190

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.82845878
2Myokymia (HP:0002411)7.74814008
3Focal seizures (HP:0007359)5.90693700
4Visual hallucinations (HP:0002367)5.19189646
5Epileptic encephalopathy (HP:0200134)4.48491813
6Febrile seizures (HP:0002373)4.10093336
7Absence seizures (HP:0002121)4.02230157
8Progressive cerebellar ataxia (HP:0002073)3.80124030
9Poor eye contact (HP:0000817)3.80017555
10Abnormality of cochlea (HP:0000375)3.75834575
11Dialeptic seizures (HP:0011146)3.72259762
12Morphological abnormality of the middle ear (HP:0008609)3.72139145
13Action tremor (HP:0002345)3.68210679
14Broad-based gait (HP:0002136)3.68040202
15Atonic seizures (HP:0010819)3.64863233
16Stenosis of the external auditory canal (HP:0000402)3.63471861
17Generalized tonic-clonic seizures (HP:0002069)3.62160058
18Ankle clonus (HP:0011448)3.51690640
19Depression (HP:0000716)3.43019677
20Supranuclear gaze palsy (HP:0000605)3.41069799
21Impaired social interactions (HP:0000735)3.39975850
22Abnormal social behavior (HP:0012433)3.39975850
23Morphological abnormality of the inner ear (HP:0011390)3.33148608
24Impaired vibration sensation in the lower limbs (HP:0002166)3.31931057
25Abnormality of the renal collecting system (HP:0004742)3.30731683
26Anxiety (HP:0000739)3.27507773
27Torticollis (HP:0000473)3.26845966
28Mutism (HP:0002300)3.19510152
29Gaze-evoked nystagmus (HP:0000640)3.13511598
30Congenital stationary night blindness (HP:0007642)3.08195000
31Dysdiadochokinesis (HP:0002075)3.06524008
32Amblyopia (HP:0000646)3.05339254
33Urinary bladder sphincter dysfunction (HP:0002839)3.05088378
34Focal dystonia (HP:0004373)3.00348023
35Hyperventilation (HP:0002883)2.98189475
36Truncal ataxia (HP:0002078)2.91709455
37Dysmetria (HP:0001310)2.89800701
38Excessive salivation (HP:0003781)2.80474935
39Drooling (HP:0002307)2.80474935
40Abnormal eating behavior (HP:0100738)2.79345195
41Megalencephaly (HP:0001355)2.79146012
42Annular pancreas (HP:0001734)2.76982656
43Hemiparesis (HP:0001269)2.76957168
44Papilledema (HP:0001085)2.76470266
45Stereotypic behavior (HP:0000733)2.75404627
46Abnormality of the lower motor neuron (HP:0002366)2.73935218
47Limb dystonia (HP:0002451)2.72842591
48Urinary urgency (HP:0000012)2.72837662
49Craniofacial dystonia (HP:0012179)2.71849970
50Postural instability (HP:0002172)2.67118218
51Progressive inability to walk (HP:0002505)2.60671191
52Abolished electroretinogram (ERG) (HP:0000550)2.60254011
53Nephronophthisis (HP:0000090)2.58881700
54Pointed chin (HP:0000307)2.56149552
55True hermaphroditism (HP:0010459)2.54039150
56Pancreatic cysts (HP:0001737)2.52657893
57Genetic anticipation (HP:0003743)2.51217703
58Medial flaring of the eyebrow (HP:0010747)2.49968280
59Cerebral inclusion bodies (HP:0100314)2.49338800
60Impaired smooth pursuit (HP:0007772)2.49110602
61Spastic gait (HP:0002064)2.48926260
62Decreased central vision (HP:0007663)2.45847872
63Neurofibrillary tangles (HP:0002185)2.45581945
64Gait imbalance (HP:0002141)2.43884069
65Retinal dysplasia (HP:0007973)2.43327083
66Scanning speech (HP:0002168)2.43098143
67Type II lissencephaly (HP:0007260)2.42101022
68Molar tooth sign on MRI (HP:0002419)2.39685070
69Abnormality of midbrain morphology (HP:0002418)2.39685070
70Obstructive sleep apnea (HP:0002870)2.39257563
71Bradykinesia (HP:0002067)2.38957958
72Abnormality of the labia minora (HP:0012880)2.38408432
73Epileptiform EEG discharges (HP:0011182)2.37229674
74Absent speech (HP:0001344)2.34013590
75Ankyloglossia (HP:0010296)2.33860478
76Amyotrophic lateral sclerosis (HP:0007354)2.31575844
77Abnormality of binocular vision (HP:0011514)2.31434201
78Diplopia (HP:0000651)2.31434201
79EEG with generalized epileptiform discharges (HP:0011198)2.29843027
80Intention tremor (HP:0002080)2.27238219
81Lower limb amyotrophy (HP:0007210)2.25100073
82Insomnia (HP:0100785)2.24199777
83Resting tremor (HP:0002322)2.23348642
84Pancreatic fibrosis (HP:0100732)2.23013927
85Abnormality of ocular smooth pursuit (HP:0000617)2.21486486
86Hypsarrhythmia (HP:0002521)2.20250903
87Impaired vibratory sensation (HP:0002495)2.19228775
88Goiter (HP:0000853)2.17625276
89Hemiplegia (HP:0002301)2.16562142
90Fetal akinesia sequence (HP:0001989)2.16445391
91Methylmalonic acidemia (HP:0002912)2.15291969
92Status epilepticus (HP:0002133)2.14671986
93Abnormality of the renal medulla (HP:0100957)2.13973806
94Lip pit (HP:0100267)2.13290597
95Abnormality of the corticospinal tract (HP:0002492)2.12901429
96Lower limb muscle weakness (HP:0007340)2.12751200
97Metabolic alkalosis (HP:0200114)2.09273605
98Polyphagia (HP:0002591)2.08450963
99Volvulus (HP:0002580)2.08171182
100Pachygyria (HP:0001302)2.07503005
101Short 4th metacarpal (HP:0010044)2.07120268
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07120268
103Inability to walk (HP:0002540)2.06594827
104Termporal pattern (HP:0011008)2.04780987
105Insidious onset (HP:0003587)2.04780987
106Attenuation of retinal blood vessels (HP:0007843)2.04471490
107Incomplete penetrance (HP:0003829)2.03855340
108Dysmetric saccades (HP:0000641)2.02892363
109Pendular nystagmus (HP:0012043)2.02174742
110Ventricular fibrillation (HP:0001663)2.01030294
111Generalized myoclonic seizures (HP:0002123)2.00675083
112Abnormality of the 4th metacarpal (HP:0010012)2.00327950
113Abnormal EKG (HP:0003115)1.99789022
114Male pseudohermaphroditism (HP:0000037)1.97193109
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.96841733
116Neuronal loss in central nervous system (HP:0002529)1.96711865
117Decreased circulating renin level (HP:0003351)1.96294164
118Renal dysplasia (HP:0000110)1.95784818
119Optic nerve hypoplasia (HP:0000609)1.94603456
120Lissencephaly (HP:0001339)1.93486952
121Congenital primary aphakia (HP:0007707)1.93472057
122Down-sloping shoulders (HP:0200021)1.92262911
123Clonus (HP:0002169)1.90904138
124Abnormal rod and cone electroretinograms (HP:0008323)1.90833585
125Nephrogenic diabetes insipidus (HP:0009806)1.88315352
126Abnormality of the renal cortex (HP:0011035)1.87097656
127Prolonged QT interval (HP:0001657)1.87084521
128Short tibia (HP:0005736)1.86077259
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85335656
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83515171
131Abnormal drinking behavior (HP:0030082)1.82530754
132Polydipsia (HP:0001959)1.82530754
133Lower limb asymmetry (HP:0100559)1.81846133
134Inappropriate behavior (HP:0000719)1.81630491
135Genital tract atresia (HP:0001827)1.79953283
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.79600872
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79600872
138Sleep apnea (HP:0010535)1.79509147
139Apathy (HP:0000741)1.79362058
140Abnormality of salivation (HP:0100755)1.78458950
141Gait ataxia (HP:0002066)1.77932297
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77913407
143Intestinal atresia (HP:0011100)1.77116616
144Cutaneous finger syndactyly (HP:0010554)1.76590334
145Dyskinesia (HP:0100660)1.76469976
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.76349179
147Palpebral edema (HP:0100540)1.76152045
148Vaginal atresia (HP:0000148)1.75803384
149Specific learning disability (HP:0001328)1.74732452
150Blue irides (HP:0000635)1.74389627
151Cupped ear (HP:0000378)1.74292222
152Autism (HP:0000717)1.74279037
153Protruding tongue (HP:0010808)1.72820969
154Mixed hearing impairment (HP:0000410)1.72817878
155Truncus arteriosus (HP:0001660)1.72273190
156Clumsiness (HP:0002312)1.72239317
157Hyperglycinemia (HP:0002154)1.70786954
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70532546
159Hypoplasia of the brainstem (HP:0002365)1.70532546
160Agitation (HP:0000713)1.70378436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.86482158
2NTRK34.22684747
3FRK3.99423770
4MAP3K93.75387389
5MARK13.72551115
6MAP4K22.63931391
7MINK12.60077154
8MAP3K42.56496976
9DAPK22.55146974
10WNK32.37372907
11NTRK22.24005676
12RIPK42.19699067
13KSR22.16438175
14MAP2K72.10916094
15PAK62.08073614
16PRKD32.01171744
17BMPR1B2.01062095
18KSR12.00690230
19GRK11.91021690
20ADRBK21.90518394
21SIK21.85425988
22CAMKK11.84324653
23CASK1.80233011
24TNIK1.70446557
25TAOK31.67742270
26CDK51.63831726
27DAPK11.58821254
28PRPF4B1.55341480
29MAP3K121.54375406
30NTRK11.53250030
31INSRR1.47155703
32MAP2K41.44675402
33FES1.44131144
34BCKDK1.41958897
35MAPK131.39883929
36TYRO31.39526651
37ARAF1.36223847
38ACVR1B1.36018494
39UHMK11.17314900
40TAOK11.14199369
41PLK21.13954625
42MAP3K131.12168751
43STK381.10949310
44PRKCG1.10320163
45GRK51.07779132
46OXSR11.05116399
47MAP3K21.02969902
48NUAK10.99711993
49CDK180.99447035
50PKN10.98438222
51CSNK1G30.96637462
52CDK150.96282570
53SGK4940.96096100
54SGK2230.96096100
55CAMKK20.95817892
56PHKG20.95120566
57PHKG10.95120566
58PNCK0.94752431
59CSNK1G10.94520298
60CDK140.91956399
61BMPR20.91331182
62CAMK2A0.89748312
63CDK190.89299899
64RAF10.88902090
65CDK11A0.84850113
66STK110.84249684
67TRIM280.82620410
68CSNK1A1L0.81657797
69CAMK10.80068568
70DYRK1A0.79944040
71TIE10.79076646
72MARK20.79014446
73SGK20.76874387
74CAMK2B0.75703975
75PRKCH0.74378381
76RET0.73354955
77PINK10.73035426
78SGK10.72790465
79PTK2B0.72256450
80ADRBK10.68773402
81ALK0.64396479
82KIT0.63860658
83TXK0.63571970
84LATS20.63527603
85SGK30.63234891
86STK38L0.63204102
87PRKACA0.62925818
88TLK10.61912893
89CSNK1G20.60808669
90PRKCZ0.60617521
91MAPKAPK50.59226810
92SIK30.56523148
93STK390.55596342
94CSNK1A10.55544816
95PAK30.54846322
96CSNK1D0.53832848
97WNK40.53331447
98ERBB30.52759333
99ZAK0.52465603
100MAP3K10.52396126
101FGR0.51832394
102RIPK10.49446433
103NEK10.49113273
104RPS6KA30.49004797
105PRKCA0.48971609
106TNK20.48709244
107FYN0.48578478
108MAP2K60.48333386
109LMTK20.47845674
110CCNB10.47686711
111PDK10.46248030
112PDPK10.45995945
113ERBB20.45984670
114MAPK100.44667047
115PRKCE0.44657877
116CAMK40.43844755
117CAMK2G0.43614561
118MKNK20.40779260
119NEK60.40537053
120NME10.40065572
121PRKG10.40060719
122FGFR20.39620897
123MAP2K10.37470076
124RPS6KA20.36944123
125BCR0.36283928
126CDC42BPA0.35754031
127BRSK10.34588528
128FER0.34371014
129PRKD20.33684865
130PRKACG0.33639866
131DAPK30.33314886
132DYRK20.33151284
133DMPK0.33118854
134ICK0.32863546
135PRKCB0.32699853
136CAMK2D0.31594522
137EPHA30.31034623
138RPS6KB10.30976507
139TAOK20.30910012
140MAPK40.30817345
141RPS6KA60.28546425
142PIK3CA0.27799564
143RPS6KA50.27736167

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69528653
2Olfactory transduction_Homo sapiens_hsa047403.16430211
3Synaptic vesicle cycle_Homo sapiens_hsa047213.04498816
4GABAergic synapse_Homo sapiens_hsa047272.84914573
5Circadian entrainment_Homo sapiens_hsa047132.80062856
6Morphine addiction_Homo sapiens_hsa050322.79260318
7Glutamatergic synapse_Homo sapiens_hsa047242.68538686
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67288046
9Long-term potentiation_Homo sapiens_hsa047202.63150490
10Amphetamine addiction_Homo sapiens_hsa050312.53907628
11Dopaminergic synapse_Homo sapiens_hsa047282.33385357
12Salivary secretion_Homo sapiens_hsa049702.09984629
13Cholinergic synapse_Homo sapiens_hsa047252.08861222
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.07954871
15Cocaine addiction_Homo sapiens_hsa050302.07776114
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07211581
17Insulin secretion_Homo sapiens_hsa049111.84110379
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82163099
19Renin secretion_Homo sapiens_hsa049241.78196094
20Gastric acid secretion_Homo sapiens_hsa049711.77127671
21Linoleic acid metabolism_Homo sapiens_hsa005911.72839656
22Taste transduction_Homo sapiens_hsa047421.72798767
23Oxytocin signaling pathway_Homo sapiens_hsa049211.72533228
24Serotonergic synapse_Homo sapiens_hsa047261.70895128
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70438829
26Long-term depression_Homo sapiens_hsa047301.68387475
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67873136
28Calcium signaling pathway_Homo sapiens_hsa040201.63257702
29Gap junction_Homo sapiens_hsa045401.53746529
30Butanoate metabolism_Homo sapiens_hsa006501.48648709
31GnRH signaling pathway_Homo sapiens_hsa049121.45646485
32Oxidative phosphorylation_Homo sapiens_hsa001901.42668783
33Ether lipid metabolism_Homo sapiens_hsa005651.39222652
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32311882
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32301981
36cAMP signaling pathway_Homo sapiens_hsa040241.31299256
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29167978
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27881297
39Axon guidance_Homo sapiens_hsa043601.27644051
40Phototransduction_Homo sapiens_hsa047441.20168298
41Glioma_Homo sapiens_hsa052141.19554003
42Tryptophan metabolism_Homo sapiens_hsa003801.12142709
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10679156
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09790759
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08739478
46Collecting duct acid secretion_Homo sapiens_hsa049661.08577963
47Type II diabetes mellitus_Homo sapiens_hsa049301.07871127
48Estrogen signaling pathway_Homo sapiens_hsa049151.07345632
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06894972
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06007021
51Melanogenesis_Homo sapiens_hsa049161.04879831
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04701635
53Parkinsons disease_Homo sapiens_hsa050121.04248294
54ErbB signaling pathway_Homo sapiens_hsa040121.03433254
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01162045
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92937513
57Cardiac muscle contraction_Homo sapiens_hsa042600.92235682
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89721282
59Oocyte meiosis_Homo sapiens_hsa041140.89698998
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87795092
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.86997121
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.86684095
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85380175
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76959235
65Choline metabolism in cancer_Homo sapiens_hsa052310.76704962
66Alcoholism_Homo sapiens_hsa050340.74309710
67Chemical carcinogenesis_Homo sapiens_hsa052040.73561538
68Pancreatic secretion_Homo sapiens_hsa049720.73079483
69VEGF signaling pathway_Homo sapiens_hsa043700.72002574
70MAPK signaling pathway_Homo sapiens_hsa040100.71354079
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70998287
72Nitrogen metabolism_Homo sapiens_hsa009100.70988035
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70875401
74Dilated cardiomyopathy_Homo sapiens_hsa054140.70520354
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69596292
76Protein export_Homo sapiens_hsa030600.68665912
77Dorso-ventral axis formation_Homo sapiens_hsa043200.67849268
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.67394051
79Non-small cell lung cancer_Homo sapiens_hsa052230.67293542
80Retinol metabolism_Homo sapiens_hsa008300.66522520
81Endometrial cancer_Homo sapiens_hsa052130.66182209
82Vibrio cholerae infection_Homo sapiens_hsa051100.65872131
83Rap1 signaling pathway_Homo sapiens_hsa040150.64810468
84ABC transporters_Homo sapiens_hsa020100.64343800
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64134768
86Thyroid hormone synthesis_Homo sapiens_hsa049180.64008311
87Caffeine metabolism_Homo sapiens_hsa002320.63303889
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.63301588
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62835325
90Type I diabetes mellitus_Homo sapiens_hsa049400.61111833
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61071120
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59560965
93Ras signaling pathway_Homo sapiens_hsa040140.58703238
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57451017
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55296960
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.54076793
97mTOR signaling pathway_Homo sapiens_hsa041500.53752032
98Arachidonic acid metabolism_Homo sapiens_hsa005900.53621065
99RNA degradation_Homo sapiens_hsa030180.52959477
100beta-Alanine metabolism_Homo sapiens_hsa004100.52751613
101Propanoate metabolism_Homo sapiens_hsa006400.52668375
102Basal transcription factors_Homo sapiens_hsa030220.51740271
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51664184
104Fatty acid biosynthesis_Homo sapiens_hsa000610.50985026
105Huntingtons disease_Homo sapiens_hsa050160.50122686
106Glycerolipid metabolism_Homo sapiens_hsa005610.49740827
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49286038
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49277778
109Regulation of autophagy_Homo sapiens_hsa041400.47845513
110Wnt signaling pathway_Homo sapiens_hsa043100.47620038
111Peroxisome_Homo sapiens_hsa041460.45764758
112Glucagon signaling pathway_Homo sapiens_hsa049220.45255511
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45033312
114Endocytosis_Homo sapiens_hsa041440.44602057
115Circadian rhythm_Homo sapiens_hsa047100.44292213
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44162538
117Renal cell carcinoma_Homo sapiens_hsa052110.44060292
118Chemokine signaling pathway_Homo sapiens_hsa040620.43691936
119Prion diseases_Homo sapiens_hsa050200.41751496
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40156431
121Colorectal cancer_Homo sapiens_hsa052100.40107778
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.39015712
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38949125
124Bile secretion_Homo sapiens_hsa049760.38878427
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38871648
126Inositol phosphate metabolism_Homo sapiens_hsa005620.38610999
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.37253425
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36410685
129Sulfur metabolism_Homo sapiens_hsa009200.36104266
130Insulin signaling pathway_Homo sapiens_hsa049100.35834467
131Selenocompound metabolism_Homo sapiens_hsa004500.35341236
132Mineral absorption_Homo sapiens_hsa049780.34426280
133Hedgehog signaling pathway_Homo sapiens_hsa043400.33260943
134African trypanosomiasis_Homo sapiens_hsa051430.32977033
135Histidine metabolism_Homo sapiens_hsa003400.32773382
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32542373
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32234128
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31621594
139Ovarian steroidogenesis_Homo sapiens_hsa049130.29594754
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28553320
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28145394
142Alzheimers disease_Homo sapiens_hsa050100.23770550
143Platelet activation_Homo sapiens_hsa046110.19944061

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