SETDB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.53444950
2nuclear pore organization (GO:0006999)5.42252404
3histone H3-K36 demethylation (GO:0070544)5.28373954
4pre-miRNA processing (GO:0031054)5.07602215
5DNA unwinding involved in DNA replication (GO:0006268)4.89920515
6protein localization to kinetochore (GO:0034501)4.74759943
7mitotic nuclear envelope disassembly (GO:0007077)4.43571069
8mitotic chromosome condensation (GO:0007076)4.34675165
9mitotic sister chromatid cohesion (GO:0007064)4.30908415
10DNA replication-dependent nucleosome organization (GO:0034723)4.29202987
11DNA replication-dependent nucleosome assembly (GO:0006335)4.29202987
12regulation of histone H3-K9 methylation (GO:0051570)4.18114615
13nuclear envelope disassembly (GO:0051081)4.17437684
14membrane disassembly (GO:0030397)4.17437684
15negative regulation of histone methylation (GO:0031061)4.13545388
16pore complex assembly (GO:0046931)4.11915819
17regulation of chromatin binding (GO:0035561)4.10712413
18sister chromatid segregation (GO:0000819)4.05589014
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03286654
20protein localization to chromosome, centromeric region (GO:0071459)4.01863101
21mitotic sister chromatid segregation (GO:0000070)3.95946901
22histone lysine demethylation (GO:0070076)3.93125604
23mitotic metaphase plate congression (GO:0007080)3.87135150
24mannose metabolic process (GO:0006013)3.86527164
25DNA replication initiation (GO:0006270)3.85696704
26DNA duplex unwinding (GO:0032508)3.82693552
27DNA geometric change (GO:0032392)3.81376529
28positive regulation of gamma-delta T cell activation (GO:0046645)3.79642116
29negative regulation of erythrocyte differentiation (GO:0045647)3.79474910
30histone demethylation (GO:0016577)3.77399760
31regulation of histone H3-K27 methylation (GO:0061085)3.75922255
32histone H3-K4 trimethylation (GO:0080182)3.75603848
33positive regulation of chromosome segregation (GO:0051984)3.73009907
34regulation of sister chromatid cohesion (GO:0007063)3.72618193
35folic acid-containing compound biosynthetic process (GO:0009396)3.69235405
36heterochromatin organization (GO:0070828)3.67636929
37regulation of nucleobase-containing compound transport (GO:0032239)3.67114048
38IMP biosynthetic process (GO:0006188)3.66935981
39histone H3-K9 demethylation (GO:0033169)3.64558584
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.62244780
41regulation of RNA export from nucleus (GO:0046831)3.57755498
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54917356
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54917356
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.54917356
45regulation of spindle organization (GO:0090224)3.53987775
46metaphase plate congression (GO:0051310)3.53585642
47kinetochore organization (GO:0051383)3.51670712
48dosage compensation (GO:0007549)3.44710767
49response to muramyl dipeptide (GO:0032495)3.43100323
50regulation of translational fidelity (GO:0006450)3.42809565
51chromatin assembly (GO:0031497)3.41979075
52DNA strand elongation involved in DNA replication (GO:0006271)3.41201137
53chromatin assembly or disassembly (GO:0006333)3.40185351
54DNA topological change (GO:0006265)3.39325774
55protein dealkylation (GO:0008214)3.38040640
56protein demethylation (GO:0006482)3.38040640
57DNA replication-independent nucleosome organization (GO:0034724)3.37438132
58DNA replication-independent nucleosome assembly (GO:0006336)3.37438132
59poly(A)+ mRNA export from nucleus (GO:0016973)3.37271666
60positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.36164160
61regulation of chromosome segregation (GO:0051983)3.35533209
62regulation of centriole replication (GO:0046599)3.35103096
63nucleosome disassembly (GO:0006337)3.33845328
64protein-DNA complex disassembly (GO:0032986)3.33845328
65regulation of posttranscriptional gene silencing (GO:0060147)3.33572824
66regulation of gene silencing by miRNA (GO:0060964)3.33572824
67regulation of gene silencing by RNA (GO:0060966)3.33572824
68meiotic chromosome segregation (GO:0045132)3.33285605
69negative regulation of DNA repair (GO:0045738)3.32943797
70regulation of DNA damage checkpoint (GO:2000001)3.28697980
71histone H2A monoubiquitination (GO:0035518)3.26499541
72protein localization to chromosome (GO:0034502)3.25599351
73DNA strand elongation (GO:0022616)3.25479385
74chromatin remodeling at centromere (GO:0031055)3.25423568
75DNA replication checkpoint (GO:0000076)3.24735082
76translesion synthesis (GO:0019985)3.23908331
77nucleobase biosynthetic process (GO:0046112)3.23617776
78regulation of mitotic spindle organization (GO:0060236)3.23461456
79regulation of histone H3-K4 methylation (GO:0051569)3.23221057
80DNA conformation change (GO:0071103)3.22675730
81regulation of gamma-delta T cell differentiation (GO:0045586)3.22387263
82negative regulation of RNA splicing (GO:0033119)3.21011706
83IMP metabolic process (GO:0046040)3.20623087
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20537476
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.20537476
86nuclear envelope organization (GO:0006998)3.20318106
87negative regulation of chromosome segregation (GO:0051985)3.19919376
88spliceosomal tri-snRNP complex assembly (GO:0000244)3.16556184
89histone H3-K4 methylation (GO:0051568)3.16455771
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16033617
91establishment of chromosome localization (GO:0051303)3.15582675
92gene silencing by RNA (GO:0031047)3.15372086
93spindle assembly checkpoint (GO:0071173)3.15294142
94regulation of gamma-delta T cell activation (GO:0046643)3.15275363
95negative regulation of mRNA processing (GO:0050686)3.14148095
96regulation of centrosome cycle (GO:0046605)3.14056483
97mRNA transport (GO:0051028)3.13846435
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11780721
99ATP-dependent chromatin remodeling (GO:0043044)3.11422885
100mitotic spindle assembly checkpoint (GO:0007094)3.11243289
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11157481
102negative regulation of sister chromatid segregation (GO:0033046)3.11157481
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.11157481
104negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11157481
105attachment of spindle microtubules to kinetochore (GO:0008608)3.10397211
106regulation of histone methylation (GO:0031060)3.09714775
107CENP-A containing nucleosome assembly (GO:0034080)3.09593430
108spindle checkpoint (GO:0031577)3.09341835
109regulation of helicase activity (GO:0051095)3.07555646
110histone H2A acetylation (GO:0043968)3.07187400
111positive regulation of gene expression, epigenetic (GO:0045815)3.07010549
112embryonic process involved in female pregnancy (GO:0060136)3.06978954
113peptidyl-lysine dimethylation (GO:0018027)3.06624255
114mRNA stabilization (GO:0048255)3.06478394
115RNA stabilization (GO:0043489)3.06478394
116paraxial mesoderm development (GO:0048339)3.06195662
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05797149
118mitotic spindle checkpoint (GO:0071174)3.05773281
119regulation of sister chromatid segregation (GO:0033045)3.05350124
120regulation of mitotic sister chromatid separation (GO:0010965)3.05350124
121regulation of mitotic sister chromatid segregation (GO:0033047)3.05350124
122protein K6-linked ubiquitination (GO:0085020)3.03210758
123* histone H3-K9 modification (GO:0061647)3.02089723
124regulation of NFAT protein import into nucleus (GO:0051532)3.01866973
125regulation of telomere maintenance via telomerase (GO:0032210)3.01203469
126kinetochore assembly (GO:0051382)2.99399556
127histone exchange (GO:0043486)2.99259424
128regulation of nuclear cell cycle DNA replication (GO:0033262)2.98195618
1293-UTR-mediated mRNA stabilization (GO:0070935)2.96922776
130negative regulation of mRNA metabolic process (GO:1903312)2.96902397
131gene silencing (GO:0016458)2.96507116
132snRNA metabolic process (GO:0016073)2.96105087
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95279112
134* histone lysine methylation (GO:0034968)2.90222667
135embryonic camera-type eye morphogenesis (GO:0048596)2.89746798
136intracellular estrogen receptor signaling pathway (GO:0030520)2.88312033
137* histone H3-K9 methylation (GO:0051567)2.86946952
138histone H4-K16 acetylation (GO:0043984)2.81919784
139histone H4 deacetylation (GO:0070933)2.81813177
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81259841
141stress granule assembly (GO:0034063)2.78895489
142B cell receptor signaling pathway (GO:0050853)2.70193284
143snRNA processing (GO:0016180)2.68657288
144* peptidyl-lysine trimethylation (GO:0018023)2.67066871
145positive regulation by host of viral transcription (GO:0043923)2.66147804
146trophectodermal cell differentiation (GO:0001829)2.64090419
147positive regulation by symbiont of host defense response (GO:0052509)2.63234763
148modulation by symbiont of host defense response (GO:0052031)2.63234763
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63234763
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63234763
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.63234763
152modulation by symbiont of host immune response (GO:0052553)2.63234763
153negative regulation of histone modification (GO:0031057)2.62038569
154* histone methylation (GO:0016571)2.58843010
155DNA synthesis involved in DNA repair (GO:0000731)2.58780053
156embryonic eye morphogenesis (GO:0048048)2.56580370
157phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54967177
158thymic T cell selection (GO:0045061)2.54771742
159negative regulation of gene expression, epigenetic (GO:0045814)2.54718264
160histone H4-K8 acetylation (GO:0043982)2.51634171
161histone H4-K5 acetylation (GO:0043981)2.51634171
162negative thymic T cell selection (GO:0045060)2.51347741
163cytoplasmic mRNA processing body assembly (GO:0033962)2.51338727
164* peptidyl-lysine methylation (GO:0018022)2.50761522
165cellular hyperosmotic response (GO:0071474)2.47158859
166DNA alkylation (GO:0006305)2.45152535
167DNA methylation (GO:0006306)2.45152535
168negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43920020
169response to peptidoglycan (GO:0032494)2.43009574
170histone H2B ubiquitination (GO:0033523)2.42461726
171definitive hemopoiesis (GO:0060216)2.42461150
172histone deubiquitination (GO:0016578)2.41004314
173negative T cell selection (GO:0043383)2.40993025
174negative regulation of cell killing (GO:0031342)2.40594847
175negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.40594847
176sister chromatid cohesion (GO:0007062)2.40416740
177protein export from nucleus (GO:0006611)2.39029830
178positive regulation of protein deacetylation (GO:0090312)2.38522068
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35940549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.71599395
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.24703572
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.52298708
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43238092
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.20919468
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98728297
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69241929
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58388145
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.53857552
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.53315252
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49091912
12MYC_22102868_ChIP-Seq_BL_Human2.39813789
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.39783258
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37894348
15AR_21909140_ChIP-Seq_LNCAP_Human2.27258724
16MAF_26560356_Chip-Seq_TH1_Human2.18878566
17KDM2B_26808549_Chip-Seq_DND41_Human2.17614734
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16584155
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12590820
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05418738
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05026446
22CIITA_25753668_ChIP-Seq_RAJI_Human2.04490127
23E2F7_22180533_ChIP-Seq_HELA_Human10.5418357
24UTX_26944678_Chip-Seq_JUKART_Human1.98306247
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97029832
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95751865
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95489210
28XRN2_22483619_ChIP-Seq_HELA_Human1.93974515
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93006397
30VDR_24763502_ChIP-Seq_THP-1_Human1.92851349
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91830938
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87206072
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.84715883
34MAF_26560356_Chip-Seq_TH2_Human1.78370696
35* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78188480
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.76506808
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75875780
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72997980
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.70708403
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67257351
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65891325
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65768692
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.65348634
44SCL_19346495_ChIP-Seq_HPC-7_Human1.65301132
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64689356
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63844209
47KDM5A_27292631_Chip-Seq_BREAST_Human1.63141268
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59185872
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.58748912
50GATA1_22025678_ChIP-Seq_K562_Human1.58542366
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57373212
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57177508
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.54012316
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53254282
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52778285
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52058651
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52058651
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52058651
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51934539
60NCOR1_26117541_ChIP-Seq_K562_Human1.51350411
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50734795
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49014895
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48494512
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46477292
65* ETS1_20019798_ChIP-Seq_JURKAT_Human1.44925497
66MYB_26560356_Chip-Seq_TH1_Human1.44489807
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43542633
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41299678
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41036282
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.40675622
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39885184
72LXR_22292898_ChIP-Seq_THP-1_Human1.37734876
73VDR_23849224_ChIP-Seq_CD4+_Human1.37370977
74TTF2_22483619_ChIP-Seq_HELA_Human1.35772840
75FOXP3_21729870_ChIP-Seq_TREG_Human1.35706202
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34193901
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33575954
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32866180
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32407410
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32303208
81GABP_19822575_ChIP-Seq_HepG2_Human1.32104314
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31865716
83KDM2B_26808549_Chip-Seq_K562_Human1.31483107
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30576314
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30350174
86* SPI1_23547873_ChIP-Seq_NB4_Human1.28894105
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28462833
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27936764
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.27904101
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27780954
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27033070
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26730845
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23313006
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22537685
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22458692
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22256591
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.22246109
98MYB_26560356_Chip-Seq_TH2_Human1.22037182
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20148206
100SPI1_23127762_ChIP-Seq_K562_Human1.18645719
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18127730
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16631754
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15829729
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14420572
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14053868
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13850493
107SMC4_20622854_ChIP-Seq_HELA_Human1.12636473
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12481673
109P68_20966046_ChIP-Seq_HELA_Human1.11402245
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11305713
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11122714
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10936424
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10028054
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09997701
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.09818307
116VDR_21846776_ChIP-Seq_THP-1_Human1.09691061
117CREB1_26743006_Chip-Seq_LNCaP_Human1.08685552
118DCP1A_22483619_ChIP-Seq_HELA_Human1.08283443
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07920715
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06979029
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06959872
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06932039
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06833371
124* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06217668
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06084368
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06021169
127TFEB_21752829_ChIP-Seq_HELA_Human1.05157834
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04788528
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02343119
130TCF7_22412390_ChIP-Seq_EML_Mouse1.01341470
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01204415
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00908073
133CHD1_26751641_Chip-Seq_LNCaP_Human0.99834592
134NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98725789
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98495088
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98448306
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98010983
138* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97642260
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97174393
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96493321
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96263871
142* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96163001
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95275358
144* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95105903
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93811322
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93698555
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93298803
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92044100
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91352392
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.90730502
151* ELK1_19687146_ChIP-ChIP_HELA_Human0.90409119
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90074106
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89889866
154SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89713535
155POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89186926
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88623742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.22922558
2MP0003111_abnormal_nucleus_morphology4.16909936
3MP0008057_abnormal_DNA_replication3.85662933
4MP0003693_abnormal_embryo_hatching3.79883329
5MP0003077_abnormal_cell_cycle3.58506716
6MP0002009_preneoplasia3.54982294
7MP0004957_abnormal_blastocyst_morpholog3.44010608
8MP0008877_abnormal_DNA_methylation3.23775826
9MP0003123_paternal_imprinting2.86492358
10MP0010352_gastrointestinal_tract_polyps2.75682747
11MP0000569_abnormal_digit_pigmentation2.60449690
12MP0008058_abnormal_DNA_repair2.55443953
13MP0008007_abnormal_cellular_replicative2.51894163
14MP0001730_embryonic_growth_arrest2.46552145
15MP0010307_abnormal_tumor_latency2.36421281
16* MP0000350_abnormal_cell_proliferation2.29033578
17MP0005076_abnormal_cell_differentiation2.27356112
18MP0004381_abnormal_hair_follicle2.26679987
19MP0003121_genomic_imprinting2.21140426
20MP0003763_abnormal_thymus_physiology2.19629995
21MP0003890_abnormal_embryonic-extraembry2.16446374
22MP0002084_abnormal_developmental_patter2.00414553
23MP0005380_embryogenesis_phenotype1.98573148
24MP0001672_abnormal_embryogenesis/_devel1.98573148
25* MP0008932_abnormal_embryonic_tissue1.97381436
26MP0001697_abnormal_embryo_size1.92906646
27MP0002085_abnormal_embryonic_tissue1.91954093
28MP0002166_altered_tumor_susceptibility1.90861128
29MP0004197_abnormal_fetal_growth/weight/1.90553044
30MP0000537_abnormal_urethra_morphology1.87240723
31MP0004185_abnormal_adipocyte_glucose1.86896268
32MP0002396_abnormal_hematopoietic_system1.82981753
33MP0003984_embryonic_growth_retardation1.80398425
34MP0002088_abnormal_embryonic_growth/wei1.77008157
35MP0002086_abnormal_extraembryonic_tissu1.74782026
36MP0003705_abnormal_hypodermis_morpholog1.72350627
37MP0003436_decreased_susceptibility_to1.68771698
38MP0001293_anophthalmia1.62351531
39MP0003119_abnormal_digestive_system1.61048166
40* MP0002080_prenatal_lethality1.60718577
41MP0002653_abnormal_ependyma_morphology1.56100828
42MP0008260_abnormal_autophagy1.55275040
43MP0005058_abnormal_lysosome_morphology1.54358114
44MP0003787_abnormal_imprinting1.52869777
45MP0003943_abnormal_hepatobiliary_system1.48999445
46MP0002398_abnormal_bone_marrow1.47461660
47MP0002210_abnormal_sex_determination1.45617578
48MP0001835_abnormal_antigen_presentation1.43103675
49MP0009053_abnormal_anal_canal1.43091379
50MP0005451_abnormal_body_composition1.41950592
51MP0000685_abnormal_immune_system1.41158029
52MP0003786_premature_aging1.40404560
53MP0010030_abnormal_orbit_morphology1.39966456
54MP0004808_abnormal_hematopoietic_stem1.39177154
55MP0001800_abnormal_humoral_immune1.38972286
56MP0003567_abnormal_fetal_cardiomyocyte1.34751403
57MP0009703_decreased_birth_body1.30000270
58MP0009672_abnormal_birth_weight1.29571947
59MP0001849_ear_inflammation1.29525950
60MP0002722_abnormal_immune_system1.27846347
61MP0001915_intracranial_hemorrhage1.27541372
62MP0001145_abnormal_male_reproductive1.27407113
63MP0009278_abnormal_bone_marrow1.27257253
64MP0000313_abnormal_cell_death1.27047869
65MP0000490_abnormal_crypts_of1.23934190
66MP0003172_abnormal_lysosome_physiology1.23043311
67MP0003937_abnormal_limbs/digits/tail_de1.21822913
68MP0005083_abnormal_biliary_tract1.21461191
69MP0000015_abnormal_ear_pigmentation1.19460236
70MP0004947_skin_inflammation1.18821421
71MP0001929_abnormal_gametogenesis1.18791156
72MP0000689_abnormal_spleen_morphology1.16006500
73MP0002405_respiratory_system_inflammati1.15468823
74MP0000428_abnormal_craniofacial_morphol1.15184134
75MP0002092_abnormal_eye_morphology1.15036392
76MP0001873_stomach_inflammation1.13717866
77MP0000653_abnormal_sex_gland1.12219803
78MP0003115_abnormal_respiratory_system1.09032072
79MP0002697_abnormal_eye_size1.08928572
80MP0005409_darkened_coat_color1.08088271
81MP0002420_abnormal_adaptive_immunity1.07474473
82MP0002019_abnormal_tumor_incidence1.06938077
83MP0001819_abnormal_immune_cell1.06461878
84MP0002006_tumorigenesis1.06030801
85MP0002429_abnormal_blood_cell1.05501896
86MP0002723_abnormal_immune_serum1.05366250
87MP0000716_abnormal_immune_system1.05094462
88MP0006292_abnormal_olfactory_placode1.04897556
89MP0002877_abnormal_melanocyte_morpholog1.04639290
90MP0003861_abnormal_nervous_system1.04102653
91MP0002419_abnormal_innate_immunity1.02164143
92MP0005075_abnormal_melanosome_morpholog1.01020584
93MP0002452_abnormal_antigen_presenting1.00355696
94MP0000733_abnormal_muscle_development1.00260160
95MP0003935_abnormal_craniofacial_develop0.99759377
96MP0001286_abnormal_eye_development0.99651967
97MP0001790_abnormal_immune_system0.97614717
98MP0005387_immune_system_phenotype0.97614717
99MP0005025_abnormal_response_to0.96660855
100MP0000703_abnormal_thymus_morphology0.96281712
101MP0003566_abnormal_cell_adhesion0.96216616
102MP0002132_abnormal_respiratory_system0.95336801
103MP0003315_abnormal_perineum_morphology0.95325211
104MP0004264_abnormal_extraembryonic_tissu0.95208415
105MP0002111_abnormal_tail_morphology0.94290579
106MP0009333_abnormal_splenocyte_physiolog0.93849437
107MP0000432_abnormal_head_morphology0.93709679
108MP0005397_hematopoietic_system_phenotyp0.90472206
109MP0001545_abnormal_hematopoietic_system0.90472206
110MP0003453_abnormal_keratinocyte_physiol0.89403879
111MP0000371_diluted_coat_color0.89224687
112MP0004858_abnormal_nervous_system0.88911644
113MP0004133_heterotaxia0.88614375
114MP0005000_abnormal_immune_tolerance0.88185662
115MP0010234_abnormal_vibrissa_follicle0.87830729
116MP0003091_abnormal_cell_migration0.87762368
117MP0001661_extended_life_span0.86618331
118MP0008961_abnormal_basal_metabolism0.86589285
119MP0000383_abnormal_hair_follicle0.85629328
120MP0002925_abnormal_cardiovascular_devel0.85191556
121MP0005621_abnormal_cell_physiology0.83771279
122MP0003656_abnormal_erythrocyte_physiolo0.83689022
123MP0000377_abnormal_hair_follicle0.83104598
124MP0001119_abnormal_female_reproductive0.82322977
125MP0003300_gastrointestinal_ulcer0.80161251
126* MP0005384_cellular_phenotype0.80036548
127MP0002075_abnormal_coat/hair_pigmentati0.79850091
128MP0004233_abnormal_muscle_weight0.79734398
129MP0003191_abnormal_cellular_cholesterol0.79468219
130MP0010630_abnormal_cardiac_muscle0.79258367
131MP0008995_early_reproductive_senescence0.78366062
132MP0003303_peritoneal_inflammation0.77779987
133MP0009931_abnormal_skin_appearance0.76802038
134MP0005187_abnormal_penis_morphology0.76381620
135MP0005174_abnormal_tail_pigmentation0.76040899
136MP0001348_abnormal_lacrimal_gland0.75851840
137MP0003698_abnormal_male_reproductive0.74906083
138MP0003755_abnormal_palate_morphology0.74208224
139MP0002249_abnormal_larynx_morphology0.71811684
140MP0003699_abnormal_female_reproductive0.70523867
141MP0002938_white_spotting0.70314008
142MP0003941_abnormal_skin_development0.70053780
143MP0003942_abnormal_urinary_system0.69957193
144MP0005023_abnormal_wound_healing0.67898787
145MP0003718_maternal_effect0.67719082
146MP0008770_decreased_survivor_rate0.66597570
147MP0002114_abnormal_axial_skeleton0.66529733
148MP0002932_abnormal_joint_morphology0.66364345
149MP0002161_abnormal_fertility/fecundity0.65538568
150MP0000266_abnormal_heart_morphology0.63080414
151MP0002116_abnormal_craniofacial_bone0.61859123
152MP0000516_abnormal_urinary_system0.61435801
153MP0005367_renal/urinary_system_phenotyp0.61435801
154MP0003385_abnormal_body_wall0.60479868

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.21105189
2Medulloblastoma (HP:0002885)3.78349455
3Astrocytoma (HP:0009592)3.64494644
4Abnormality of the astrocytes (HP:0100707)3.64494644
5Chromsome breakage (HP:0040012)3.41457170
6Asymmetry of the thorax (HP:0001555)3.22645431
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21353344
8Volvulus (HP:0002580)3.20893893
9Colon cancer (HP:0003003)3.19387943
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16899431
11Short 4th metacarpal (HP:0010044)3.16899431
12Colitis (HP:0002583)3.16605827
13Birth length less than 3rd percentile (HP:0003561)3.16304549
14Glioma (HP:0009733)3.05517202
15Metaphyseal cupping (HP:0003021)2.99569542
16Abnormality of the labia minora (HP:0012880)2.97918613
17Neoplasm of the oral cavity (HP:0100649)2.94335857
18Selective tooth agenesis (HP:0001592)2.90213236
19Increased nuchal translucency (HP:0010880)2.84121030
20Ectopic kidney (HP:0000086)2.80698710
21Rhabdomyosarcoma (HP:0002859)2.78763177
22Aplasia/Hypoplasia of the sternum (HP:0006714)2.66001974
23Neoplasm of striated muscle (HP:0009728)2.59287107
24Abnormality of the fingertips (HP:0001211)2.57898966
25Abnormality of chromosome stability (HP:0003220)2.55839313
26Viral hepatitis (HP:0006562)2.50846230
27Agnosia (HP:0010524)2.47429206
28Proximal placement of thumb (HP:0009623)2.45686525
29Impulsivity (HP:0100710)2.44681147
30Meckel diverticulum (HP:0002245)2.44564409
31Gastrointestinal inflammation (HP:0004386)2.43503162
32Patellar aplasia (HP:0006443)2.42580198
33Deviation of the thumb (HP:0009603)2.40163496
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.36802411
35Prominent nose (HP:0000448)2.35129010
36Abnormality of the 4th metacarpal (HP:0010012)2.34564476
37Abnormality of the ileum (HP:0001549)2.33930559
38Germ cell neoplasia (HP:0100728)2.33804713
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33370077
40Gastrointestinal carcinoma (HP:0002672)2.30945494
41Malignant gastrointestinal tract tumors (HP:0006749)2.30945494
42Long eyelashes (HP:0000527)2.30681778
43Panhypogammaglobulinemia (HP:0003139)2.28343592
44Facial hemangioma (HP:0000329)2.28036217
45Recurrent viral infections (HP:0004429)2.27387252
46Eczematoid dermatitis (HP:0000976)2.26971291
47Heterotopia (HP:0002282)2.26714867
48Recurrent fungal infections (HP:0002841)2.23725548
49Breast hypoplasia (HP:0003187)2.22726501
50Skull defect (HP:0001362)2.22100284
51Aplasia/Hypoplasia of the patella (HP:0006498)2.20739440
52Thin bony cortex (HP:0002753)2.20566149
53Cafe-au-lait spot (HP:0000957)2.20258995
54Myelodysplasia (HP:0002863)2.19268575
55Shawl scrotum (HP:0000049)2.19158937
56Recurrent abscess formation (HP:0002722)2.18996310
57Renal duplication (HP:0000075)2.18646389
58Duodenal stenosis (HP:0100867)2.17648265
59Small intestinal stenosis (HP:0012848)2.17648265
60Sandal gap (HP:0001852)2.17233801
61Hyperacusis (HP:0010780)2.17056297
62Subacute progressive viral hepatitis (HP:0006572)2.16904799
63Abnormality of the carotid arteries (HP:0005344)2.16610572
64Dislocated radial head (HP:0003083)2.15951613
65Inflammation of the large intestine (HP:0002037)2.15776534
66Recurrent cutaneous fungal infections (HP:0011370)2.14260927
67Chronic mucocutaneous candidiasis (HP:0002728)2.14260927
68Flat acetabular roof (HP:0003180)2.14193473
69Missing ribs (HP:0000921)2.14179108
70Abnormality of the thoracic spine (HP:0100711)2.12784855
71Basal cell carcinoma (HP:0002671)2.11372675
72High pitched voice (HP:0001620)2.11180228
73Recurrent bacterial skin infections (HP:0005406)2.10933543
74Abnormality of DNA repair (HP:0003254)2.10873205
75Supernumerary spleens (HP:0009799)2.07842481
76Deep palmar crease (HP:0006191)2.07193617
77Syringomyelia (HP:0003396)2.06136122
78Spinal cord lesions (HP:0100561)2.06136122
79Papillary thyroid carcinoma (HP:0002895)2.05867162
80Abnormality of the radial head (HP:0003995)2.05829041
81Sparse lateral eyebrow (HP:0005338)2.05398317
82Renovascular hypertension (HP:0100817)2.05276391
83Abnormal number of incisors (HP:0011064)2.04302137
84Supernumerary ribs (HP:0005815)2.02709904
85Abnormality of the preputium (HP:0100587)2.02111358
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00183986
87Dysmetric saccades (HP:0000641)1.99589537
88Atresia of the external auditory canal (HP:0000413)1.99128693
89High anterior hairline (HP:0009890)1.98132155
90Biliary tract neoplasm (HP:0100574)1.97374379
91Abnormality of the lower motor neuron (HP:0002366)1.96272439
92Broad palm (HP:0001169)1.96160121
93Pelvic girdle muscle weakness (HP:0003749)1.95740849
94Narrow palate (HP:0000189)1.95206650
95Abnormality of the anterior horn cell (HP:0006802)1.93459241
96Degeneration of anterior horn cells (HP:0002398)1.93459241
97Abnormal lung lobation (HP:0002101)1.92090998
98Urethral obstruction (HP:0000796)1.91631642
99Broad face (HP:0000283)1.91571725
100Broad thumb (HP:0011304)1.91089865
101Acute lymphatic leukemia (HP:0006721)1.90999254
102Pseudobulbar signs (HP:0002200)1.90639119
103Trigonocephaly (HP:0000243)1.89798394
104Supernumerary bones of the axial skeleton (HP:0009144)1.88492517
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.88068332
106Cellulitis (HP:0100658)1.87529556
107Anal stenosis (HP:0002025)1.87393282
108Broad distal phalanx of finger (HP:0009836)1.87191822
109Overlapping toe (HP:0001845)1.86258222
110Oligodactyly (HP:0012165)1.85836317
111Sloping forehead (HP:0000340)1.85519957
11211 pairs of ribs (HP:0000878)1.84729664
113Macroorchidism (HP:0000053)1.82829642
114Obsessive-compulsive behavior (HP:0000722)1.82008976
115Neoplasm of the pancreas (HP:0002894)1.81965024
116Abnormality of the duodenum (HP:0002246)1.81561578
117Micronodular cirrhosis (HP:0001413)1.81499699
118Nephroblastoma (Wilms tumor) (HP:0002667)1.79706535
119Deformed sella turcica (HP:0002681)1.79491879
120Gastrointestinal infarctions (HP:0005244)1.78708994
121Absent thumb (HP:0009777)1.78197135
122Absent radius (HP:0003974)1.77856985
123Leiomyosarcoma (HP:0100243)1.77460953
124Uterine leiomyosarcoma (HP:0002891)1.77460953
125Low anterior hairline (HP:0000294)1.77059332
126Deep philtrum (HP:0002002)1.76393329
127Neonatal hypoglycemia (HP:0001998)1.76186093
128Truncal obesity (HP:0001956)1.75381484
129Skin tags (HP:0010609)1.75168055
130Rib fusion (HP:0000902)1.74565904
131Patellar dislocation (HP:0002999)1.74121968
132Hepatitis (HP:0012115)1.73691911
133Bowel incontinence (HP:0002607)1.73095962
134Tracheoesophageal fistula (HP:0002575)1.72077569
135Cutis marmorata (HP:0000965)1.70393178
136Embryonal renal neoplasm (HP:0011794)1.70078765
137Hypoplastic labia majora (HP:0000059)1.70011855
138Long palpebral fissure (HP:0000637)1.69281514
139Thoracic kyphosis (HP:0002942)1.69251426
140Amaurosis fugax (HP:0100576)1.69001144
141Broad phalanges of the hand (HP:0009768)1.68108669
142Short humerus (HP:0005792)1.68057011
143Acute myeloid leukemia (HP:0004808)1.67369801
144Abnormality of chromosome segregation (HP:0002916)1.66972284
145Persistence of primary teeth (HP:0006335)1.66603035
146Short 1st metacarpal (HP:0010034)1.66374655
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.66374655
148Pointed chin (HP:0000307)1.61055607
149Relative macrocephaly (HP:0004482)1.59997564
150Prominent occiput (HP:0000269)1.59994919
151Abnormal large intestine physiology (HP:0012700)1.59898543
152Mediastinal lymphadenopathy (HP:0100721)1.58109824
153Absent frontal sinuses (HP:0002688)1.57488351
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56458186
155Disproportionate tall stature (HP:0001519)1.55620562
156Increased IgE level (HP:0003212)1.55007077
157Spina bifida occulta (HP:0003298)1.54375442
158Gingivitis (HP:0000230)1.53414882
159Abnormality of the aortic arch (HP:0012303)1.52968597
160J-shaped sella turcica (HP:0002680)1.52041772
161T lymphocytopenia (HP:0005403)1.51213087
162Combined immunodeficiency (HP:0005387)1.51175303
163Recurrent skin infections (HP:0001581)1.50535565
164Cutaneous melanoma (HP:0012056)1.50391212
165Abnormality of the calcaneus (HP:0008364)1.50107247
166Aplasia/Hypoplasia of the thymus (HP:0010515)1.49772760
167Slow saccadic eye movements (HP:0000514)1.49397594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.94788252
2CDC74.68998148
3SMG13.07889625
4NEK23.01136374
5EEF2K2.85691472
6BRD42.68265364
7MAP3K102.60837811
8TTK2.58814241
9WEE12.40929650
10SRPK12.30843188
11SIK12.18537837
12FGFR42.04661270
13PKN22.03776784
14LATS12.01257206
15PRPF4B1.94628331
16ATR1.93403285
17CDK71.88618265
18PASK1.85822604
19ERN11.82030205
20NEK11.78049815
21PLK11.77496065
22ICK1.76854239
23RPS6KB21.72783369
24RIPK41.69909623
25CHEK21.65810659
26MKNK11.64762117
27TSSK61.63735701
28SCYL21.61477989
29CHEK11.61429154
30CDK41.60444414
31BUB11.59715164
32MAP3K141.46353002
33PLK41.45673800
34EIF2AK11.45322798
35FGFR31.45280495
36TNK21.42620045
37AURKB1.42324772
38MAP4K11.37859787
39MARK21.36596468
40STK101.36532949
41MAP2K21.36363291
42MAP3K81.33615175
43MTOR1.32365541
44PLK31.30448303
45MAP2K31.29520081
46MKNK21.29039191
47TYK21.28438121
48ACVR1B1.28361959
49ATM1.27053150
50ALK1.26910848
51RET1.25045466
52DYRK31.18932806
53IRAK31.16775978
54* CDK21.15913009
55BLK1.15141971
56CDK61.12775957
57STK31.09734690
58STK41.09464693
59AKT31.07202537
60EPHA21.06253522
61TYRO31.03006723
62CAMK1D1.02550985
63BTK1.01726136
64PAK41.01165991
65MAP3K130.99966184
66PNCK0.99523361
67PDGFRA0.98679926
68MELK0.96685675
69LATS20.93369076
70CSF1R0.92045474
71NEK60.91484836
72TRIB30.91406245
73CDK10.91010734
74MAP3K70.89838841
75KSR20.89559515
76CDK90.89006002
77TGFBR10.87552139
78BRSK20.86277203
79MAPK110.86130088
80YES10.85051643
81IRAK40.84917013
82PTK60.84908942
83GRK60.83581180
84AURKA0.81532157
85IKBKE0.80045097
86RPS6KA40.79967449
87ZAP700.79804508
88CAMK1G0.79643357
89FES0.74710704
90KSR10.73793702
91PRKD20.73781064
92PDPK10.72918382
93MARK30.71916513
94HCK0.71373914
95RPS6KL10.69420877
96RPS6KC10.69420877
97FGFR10.65175542
98CSNK1D0.64966318
99TBK10.64903640
100PRKDC0.64440185
101PDK10.62790137
102JAK20.61787118
103TLK10.61730412
104JAK30.61089348
105BRSK10.60283891
106MAPK140.59716858
107TESK20.58434036
108CSNK1E0.58432750
109CSK0.57955843
110CDC42BPA0.57293949
111RPS6KA60.56925001
112JAK10.55982247
113PAK20.55954680
114FLT30.54875191
115PIM10.54771286
116IRAK20.52684312
117WNK10.51774260
118VRK10.51196920
119AKT20.51031630
120FGR0.50467732
121TTN0.50345205
122GSK3B0.50211833
123PDGFRB0.50114815
124RPS6KA20.49319195
125AKT10.48563346
126RAF10.45913614
127TAOK30.45538085
128MAPK70.45206384
129KIT0.44697640
130CHUK0.44621968
131CSNK2A20.44617410
132ZAK0.44593396
133DYRK1B0.43883682
134SIK20.43224980
135LCK0.43075278
136PRKD30.42893388
137MAPK30.42575218
138MAPK10.42315442
139RIPK10.42065841
140MAP3K20.40919666
141HIPK20.40898211
142IRAK10.39226959
143RPS6KB10.36368823
144TAOK20.35285033
145MAPK100.35020461
146BRAF0.34311307
147PRKCI0.34161036
148ERBB20.33849667
149PAK10.33571848
150MAPK80.30893005
151LRRK20.30706367
152BMX0.30556704
153STK38L0.29723301
154RPS6KA10.29560289
155FGFR20.28287531
156SGK30.27697023
157CSNK1A1L0.26884023
158MAP3K60.23062776

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.90257313
2Mismatch repair_Homo sapiens_hsa034303.61099674
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35679883
4RNA transport_Homo sapiens_hsa030133.35300669
5Spliceosome_Homo sapiens_hsa030403.17887501
6Cell cycle_Homo sapiens_hsa041103.12758935
7One carbon pool by folate_Homo sapiens_hsa006703.01001867
8mRNA surveillance pathway_Homo sapiens_hsa030152.67866986
9Base excision repair_Homo sapiens_hsa034102.55768127
10Homologous recombination_Homo sapiens_hsa034402.47936860
11Fanconi anemia pathway_Homo sapiens_hsa034602.43816737
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39671874
13Nucleotide excision repair_Homo sapiens_hsa034202.16890125
14Non-homologous end-joining_Homo sapiens_hsa034501.97683838
15RNA degradation_Homo sapiens_hsa030181.90339843
16Other glycan degradation_Homo sapiens_hsa005111.89342386
17RNA polymerase_Homo sapiens_hsa030201.86945141
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.67858655
19Basal transcription factors_Homo sapiens_hsa030221.66968389
20p53 signaling pathway_Homo sapiens_hsa041151.54676570
21Systemic lupus erythematosus_Homo sapiens_hsa053221.52373356
22MicroRNAs in cancer_Homo sapiens_hsa052061.50253550
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48249756
24Notch signaling pathway_Homo sapiens_hsa043301.37882352
25Viral carcinogenesis_Homo sapiens_hsa052031.35763644
26Osteoclast differentiation_Homo sapiens_hsa043801.34119108
27Oocyte meiosis_Homo sapiens_hsa041141.31519644
28Pyrimidine metabolism_Homo sapiens_hsa002401.30817102
29* Lysine degradation_Homo sapiens_hsa003101.30325373
30Basal cell carcinoma_Homo sapiens_hsa052171.26185892
31Colorectal cancer_Homo sapiens_hsa052101.23025338
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22487866
33Chronic myeloid leukemia_Homo sapiens_hsa052201.20782387
34mTOR signaling pathway_Homo sapiens_hsa041501.19150239
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15143077
36* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14267482
37Hepatitis C_Homo sapiens_hsa051601.11920973
38Epstein-Barr virus infection_Homo sapiens_hsa051691.11849134
39Small cell lung cancer_Homo sapiens_hsa052221.11338148
40Thyroid cancer_Homo sapiens_hsa052161.09776233
41Herpes simplex infection_Homo sapiens_hsa051681.09739690
42HTLV-I infection_Homo sapiens_hsa051661.08994125
43Selenocompound metabolism_Homo sapiens_hsa004501.08293375
44Leishmaniasis_Homo sapiens_hsa051401.07136252
45Hippo signaling pathway_Homo sapiens_hsa043901.07120964
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04498491
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04388657
48Endometrial cancer_Homo sapiens_hsa052131.02530445
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01905976
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01352570
51Primary immunodeficiency_Homo sapiens_hsa053401.00588850
52Non-small cell lung cancer_Homo sapiens_hsa052230.97074831
53Adherens junction_Homo sapiens_hsa045200.95382799
54Insulin resistance_Homo sapiens_hsa049310.94223393
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.93634068
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.90960276
57Toxoplasmosis_Homo sapiens_hsa051450.89791701
58TGF-beta signaling pathway_Homo sapiens_hsa043500.87177349
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.86690828
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86417648
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85363690
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.82889002
63TNF signaling pathway_Homo sapiens_hsa046680.82256194
64Hedgehog signaling pathway_Homo sapiens_hsa043400.80344018
65Antigen processing and presentation_Homo sapiens_hsa046120.79374309
66Alcoholism_Homo sapiens_hsa050340.78755324
67Pancreatic cancer_Homo sapiens_hsa052120.78691884
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78565748
69Biosynthesis of amino acids_Homo sapiens_hsa012300.71251543
70Acute myeloid leukemia_Homo sapiens_hsa052210.70415127
71Ribosome_Homo sapiens_hsa030100.69739852
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.69705953
73Bladder cancer_Homo sapiens_hsa052190.69448547
74Prostate cancer_Homo sapiens_hsa052150.68302140
75Tuberculosis_Homo sapiens_hsa051520.67916545
76Chemokine signaling pathway_Homo sapiens_hsa040620.67778466
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67280590
78Dorso-ventral axis formation_Homo sapiens_hsa043200.67271207
79Platelet activation_Homo sapiens_hsa046110.66152639
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.65055480
81Proteoglycans in cancer_Homo sapiens_hsa052050.64159326
82Type II diabetes mellitus_Homo sapiens_hsa049300.63807271
83Pathways in cancer_Homo sapiens_hsa052000.63647599
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.61382742
85Wnt signaling pathway_Homo sapiens_hsa043100.60689979
86Purine metabolism_Homo sapiens_hsa002300.60232391
87Glioma_Homo sapiens_hsa052140.59072530
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58340319
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56953558
90Viral myocarditis_Homo sapiens_hsa054160.56385870
91Fructose and mannose metabolism_Homo sapiens_hsa000510.56357187
92Hepatitis B_Homo sapiens_hsa051610.56294848
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.54080588
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53469421
95GnRH signaling pathway_Homo sapiens_hsa049120.52671131
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52666595
97FoxO signaling pathway_Homo sapiens_hsa040680.52030169
98MAPK signaling pathway_Homo sapiens_hsa040100.50744575
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.50341985
100Apoptosis_Homo sapiens_hsa042100.48249935
101Endocytosis_Homo sapiens_hsa041440.47243997
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45781330
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43620664
104Influenza A_Homo sapiens_hsa051640.42134758
105Renal cell carcinoma_Homo sapiens_hsa052110.41206756
106Tight junction_Homo sapiens_hsa045300.40902414
107HIF-1 signaling pathway_Homo sapiens_hsa040660.40624502
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40556484
109Melanoma_Homo sapiens_hsa052180.39573314
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38531826
111B cell receptor signaling pathway_Homo sapiens_hsa046620.35206680
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.34904595
113Measles_Homo sapiens_hsa051620.33040066
114Insulin signaling pathway_Homo sapiens_hsa049100.32538443
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31525928
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30229149
117Focal adhesion_Homo sapiens_hsa045100.29530607
118ErbB signaling pathway_Homo sapiens_hsa040120.29249061
119AMPK signaling pathway_Homo sapiens_hsa041520.28137347
120Legionellosis_Homo sapiens_hsa051340.27931104
121Prolactin signaling pathway_Homo sapiens_hsa049170.27930771
122Estrogen signaling pathway_Homo sapiens_hsa049150.26208831
123VEGF signaling pathway_Homo sapiens_hsa043700.25887421
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25774134
125T cell receptor signaling pathway_Homo sapiens_hsa046600.25441737
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25249456
127Inositol phosphate metabolism_Homo sapiens_hsa005620.24175891
128Proteasome_Homo sapiens_hsa030500.23757046
129Pentose phosphate pathway_Homo sapiens_hsa000300.23469843
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.22748740
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22305138
132Choline metabolism in cancer_Homo sapiens_hsa052310.20565301

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »