SETD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.22806746
2daunorubicin metabolic process (GO:0044597)8.22806746
3polyketide metabolic process (GO:0030638)8.22806746
4regulation of nuclear cell cycle DNA replication (GO:0033262)6.52329872
5regulation of telomere maintenance via telomerase (GO:0032210)5.91383691
6somite rostral/caudal axis specification (GO:0032525)5.41209975
7negative regulation of telomere maintenance (GO:0032205)5.24406221
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.12675180
9rRNA methylation (GO:0031167)5.12360480
10rRNA modification (GO:0000154)5.04934178
11aminoglycoside antibiotic metabolic process (GO:0030647)5.01837152
12regulation of MHC class I biosynthetic process (GO:0045343)4.98900052
13maintenance of protein location in nucleus (GO:0051457)4.92534654
14negative regulation of telomerase activity (GO:0051974)4.79334463
15histone H4-K12 acetylation (GO:0043983)4.78652679
16negative regulation of epidermis development (GO:0045683)4.74249204
17DNA damage response, detection of DNA damage (GO:0042769)4.60252851
18positive regulation of DNA-dependent DNA replication (GO:2000105)4.59462531
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.37145328
20negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.36211043
21DNA replication checkpoint (GO:0000076)4.35721788
22behavioral response to nicotine (GO:0035095)4.29546095
23muscle organ morphogenesis (GO:0048644)4.29345831
24negative regulation of epidermal cell differentiation (GO:0045605)4.29148814
25regulation of response to osmotic stress (GO:0047484)4.25552926
26notochord development (GO:0030903)4.23302594
27mitotic sister chromatid segregation (GO:0000070)4.13922815
28protein localization to kinetochore (GO:0034501)4.11224280
29histone H4-K5 acetylation (GO:0043981)4.09539125
30histone H4-K8 acetylation (GO:0043982)4.09539125
31regulation of mitotic spindle checkpoint (GO:1903504)4.07344142
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.07344142
33DNA double-strand break processing (GO:0000729)3.97604363
34rRNA transcription (GO:0009303)3.94314134
35maturation of 5.8S rRNA (GO:0000460)3.92467909
36negative regulation of cell cycle G2/M phase transition (GO:1902750)3.91635506
37interferon-gamma production (GO:0032609)3.87396736
38regulation of meiosis I (GO:0060631)3.79400180
39regulation of telomere maintenance (GO:0032204)3.79124564
40cell fate commitment involved in formation of primary germ layer (GO:0060795)3.76256758
41regulation of cilium movement (GO:0003352)3.75855964
42protein K6-linked ubiquitination (GO:0085020)3.75350053
43synapsis (GO:0007129)3.72512630
44protein localization to cilium (GO:0061512)3.64916940
45histone H2A acetylation (GO:0043968)3.63421726
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.61980178
47epithelial cilium movement (GO:0003351)3.61835224
48quinone metabolic process (GO:1901661)3.54842235
49negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.53547183
50ribosome biogenesis (GO:0042254)3.49251675
51regulation of translation in response to stress (GO:0043555)3.45824119
52receptor recycling (GO:0001881)3.42274141
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.37300187
54response to pheromone (GO:0019236)3.35557588
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.33959214
56NADH dehydrogenase complex assembly (GO:0010257)3.33959214
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33959214
58branching involved in mammary gland duct morphogenesis (GO:0060444)3.32293688
59nucleoside transmembrane transport (GO:1901642)3.32024722
60negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.31006151
61L-fucose catabolic process (GO:0042355)3.30860710
62fucose catabolic process (GO:0019317)3.30860710
63L-fucose metabolic process (GO:0042354)3.30860710
64axoneme assembly (GO:0035082)3.29174043
65DNA deamination (GO:0045006)3.29173871
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27677151
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27677151
68intraciliary transport (GO:0042073)3.24036247
69termination of RNA polymerase III transcription (GO:0006386)3.22563276
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.22563276
71regulation of DNA-dependent DNA replication (GO:0090329)3.22515406
72regulation of telomerase activity (GO:0051972)3.21988380
73protein localization to chromosome, centromeric region (GO:0071459)3.19607823
74sister chromatid segregation (GO:0000819)3.19071214
75phenol-containing compound catabolic process (GO:0019336)3.17279900
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.16095444
77mitochondrial DNA replication (GO:0006264)3.14161425
78mannosylation (GO:0097502)3.12863787
79resolution of meiotic recombination intermediates (GO:0000712)3.11969785
80regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.10747648
81DNA replication-dependent nucleosome organization (GO:0034723)3.10395428
82DNA replication-dependent nucleosome assembly (GO:0006335)3.10395428
83protein deneddylation (GO:0000338)3.09658138
84piRNA metabolic process (GO:0034587)3.07962655
85axonemal dynein complex assembly (GO:0070286)3.07425858
86cilium movement (GO:0003341)3.06613763
87DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.05304619
88omega-hydroxylase P450 pathway (GO:0097267)3.05152906
89cullin deneddylation (GO:0010388)3.00375447
90DNA catabolic process, exonucleolytic (GO:0000738)2.99771839
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99255564
92pseudouridine synthesis (GO:0001522)2.98912766
93cytidine deamination (GO:0009972)2.98850479
94cytidine metabolic process (GO:0046087)2.98850479
95cytidine catabolic process (GO:0006216)2.98850479
96regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97523837
97platelet dense granule organization (GO:0060155)2.97494257
98positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.96624735
99protein complex biogenesis (GO:0070271)2.94249843
100primitive streak formation (GO:0090009)2.94036607
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93083501
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92456066
103meiotic chromosome segregation (GO:0045132)2.92327331
104nonmotile primary cilium assembly (GO:0035058)2.92103941
105signal transduction involved in regulation of gene expression (GO:0023019)2.92101877
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91142133
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.91142133
108kinetochore assembly (GO:0051382)2.91094640
109replication fork processing (GO:0031297)2.91028098
110mitochondrial respiratory chain complex assembly (GO:0033108)2.88351792
111regulation of gene silencing by RNA (GO:0060966)2.86598606
112regulation of posttranscriptional gene silencing (GO:0060147)2.86598606
113regulation of gene silencing by miRNA (GO:0060964)2.86598606
114histone H4-K16 acetylation (GO:0043984)2.85877593
115recombinational repair (GO:0000725)2.83459296
116respiratory chain complex IV assembly (GO:0008535)2.83242195
117DNA damage response, signal transduction resulting in transcription (GO:0042772)2.82556483
118transepithelial transport (GO:0070633)2.82145656
119regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.81084500
120positive regulation of defense response to virus by host (GO:0002230)2.81052076
121protein polyglutamylation (GO:0018095)2.80675722
122transcription from RNA polymerase I promoter (GO:0006360)2.79932070
123regulation of double-strand break repair (GO:2000779)2.79775926
124double-strand break repair via homologous recombination (GO:0000724)2.79542640
125kynurenine metabolic process (GO:0070189)2.79448953
126regulation of mitochondrial translation (GO:0070129)2.78701278
127DNA methylation involved in gamete generation (GO:0043046)2.76974674
128RNA methylation (GO:0001510)2.76903404
129tryptophan catabolic process (GO:0006569)2.76863724
130indole-containing compound catabolic process (GO:0042436)2.76863724
131indolalkylamine catabolic process (GO:0046218)2.76863724
132negative regulation of signal transduction by p53 class mediator (GO:1901797)2.75578142
133centriole replication (GO:0007099)2.74369924
134rRNA catabolic process (GO:0016075)2.74239664
135prenylation (GO:0097354)2.73137302
136protein prenylation (GO:0018342)2.73137302
137peptidyl-histidine modification (GO:0018202)2.72372978
138DNA replication initiation (GO:0006270)2.71228334
139reciprocal DNA recombination (GO:0035825)2.69495973
140reciprocal meiotic recombination (GO:0007131)2.69495973
141mitochondrion distribution (GO:0048311)2.69296797
142response to dietary excess (GO:0002021)2.69263224
143microtubule depolymerization (GO:0007019)2.68827004
144mitotic metaphase plate congression (GO:0007080)2.68724350
145cilium morphogenesis (GO:0060271)2.68362117
146ncRNA catabolic process (GO:0034661)2.67757993
147GDP-mannose metabolic process (GO:0019673)2.61957099
148intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.61898854
149cilium organization (GO:0044782)2.61098836
150centriole assembly (GO:0098534)2.60983914
151ribonucleoprotein complex biogenesis (GO:0022613)2.58402452
152tRNA methylation (GO:0030488)2.57984710
153sulfate transport (GO:0008272)2.57692756
154indolalkylamine metabolic process (GO:0006586)2.57238039
155tRNA processing (GO:0008033)2.57189115
156male meiosis (GO:0007140)2.56551697
157ubiquinone biosynthetic process (GO:0006744)2.55897772
158intestinal epithelial cell development (GO:0060576)2.55874595
159detection of light stimulus involved in visual perception (GO:0050908)2.55483271
160detection of light stimulus involved in sensory perception (GO:0050962)2.55483271
161water-soluble vitamin biosynthetic process (GO:0042364)2.55129792
162maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54681191
163bone trabecula formation (GO:0060346)2.54469659
164microtubule severing (GO:0051013)2.54283124
165nuclear pore complex assembly (GO:0051292)2.53754372
166cilium assembly (GO:0042384)2.53448865
167nucleoside transport (GO:0015858)2.53372335
168transcription from RNA polymerase III promoter (GO:0006383)2.51824332
169mitotic G2/M transition checkpoint (GO:0044818)2.50911585
170L-methionine salvage (GO:0071267)2.50832627
171L-methionine biosynthetic process (GO:0071265)2.50832627
172amino acid salvage (GO:0043102)2.50832627
173cilium or flagellum-dependent cell motility (GO:0001539)2.48859068
174attachment of spindle microtubules to kinetochore (GO:0008608)2.48313328
175protein-cofactor linkage (GO:0018065)2.47678156
176somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47241128
177isotype switching (GO:0045190)2.47241128
178somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47241128
179mitochondrial RNA metabolic process (GO:0000959)2.45978494
180ubiquinone metabolic process (GO:0006743)2.45722956
181kidney morphogenesis (GO:0060993)2.44649826
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43104889
183male meiosis I (GO:0007141)2.41607879
184proteasome assembly (GO:0043248)2.41451368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.41313500
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.17069420
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.17069420
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.17069420
5E2F7_22180533_ChIP-Seq_HELA_Human5.04226573
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.44641922
7TP63_19390658_ChIP-ChIP_HaCaT_Human4.13184562
8ZNF274_21170338_ChIP-Seq_K562_Hela4.00507365
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03027001
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62846807
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61268241
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61258618
13IRF1_19129219_ChIP-ChIP_H3396_Human2.55566564
14VDR_22108803_ChIP-Seq_LS180_Human2.44958015
15EWS_26573619_Chip-Seq_HEK293_Human2.41485516
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34167738
17FUS_26573619_Chip-Seq_HEK293_Human2.29791314
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28356765
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.19400209
20NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.16694810
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13762133
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13174734
23ELK1_19687146_ChIP-ChIP_HELA_Human2.13037724
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.11509294
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.04924838
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.01720240
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.99617991
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94899207
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92770037
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92528549
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82695381
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81837020
33GBX2_23144817_ChIP-Seq_PC3_Human1.78816615
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.77242468
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76683361
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.76528280
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74480390
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.71881904
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69440952
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68340334
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67891784
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67033455
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66919158
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66682400
45RNF2_27304074_Chip-Seq_NSC_Mouse1.66558860
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65962755
47P300_19829295_ChIP-Seq_ESCs_Human1.65626393
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63776570
49EZH2_22144423_ChIP-Seq_EOC_Human1.63551821
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62122752
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60526212
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60242797
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60207877
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56907057
55ER_23166858_ChIP-Seq_MCF-7_Human1.53236519
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52761480
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.51746887
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49255413
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45707672
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45217832
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.43131923
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41322976
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41274898
64* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40596933
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39051172
66TP53_22573176_ChIP-Seq_HFKS_Human1.38855438
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35920490
68* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35856045
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34306077
70CBP_20019798_ChIP-Seq_JUKART_Human1.32000278
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32000278
72TAF15_26573619_Chip-Seq_HEK293_Human1.30877339
73* GABP_19822575_ChIP-Seq_HepG2_Human1.30806590
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29666149
75TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.29214136
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27998870
77* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25557907
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24277853
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21648878
80NANOG_18692474_ChIP-Seq_MESCs_Mouse1.21630315
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20401278
82BCAT_22108803_ChIP-Seq_LS180_Human1.20374367
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20331479
84* SOX2_19829295_ChIP-Seq_ESCs_Human1.18921123
85* NANOG_19829295_ChIP-Seq_ESCs_Human1.18921123
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16832711
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16832711
88KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16099535
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15968829
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.15957612
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15957612
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.15317628
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14158210
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13780934
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13458364
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12969570
97STAT3_23295773_ChIP-Seq_U87_Human1.12603056
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.10487122
99NCOR_22424771_ChIP-Seq_293T_Human1.09284383
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08866663
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07762969
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.07390372
103TCF4_22108803_ChIP-Seq_LS180_Human1.06816877
104PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06514084
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06435743
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05295509
107CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05243354
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05181334
109E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03925713
110* FOXP3_21729870_ChIP-Seq_TREG_Human1.03869640
111HOXB7_26014856_ChIP-Seq_BT474_Human1.03608388
112AR_20517297_ChIP-Seq_VCAP_Human1.01989529
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01642623
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01427163
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.01166653
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01163959
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00596948
118STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00429021
119NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99055846
120TCF4_23295773_ChIP-Seq_U87_Human0.99042930
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.98183201
122* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96884631
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.96384276
124RUNX2_22187159_ChIP-Seq_PCA_Human0.96009071
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95225952
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94519265
127SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94079145
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93673362
129TTF2_22483619_ChIP-Seq_HELA_Human0.93465437
130ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93243287
131SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92354784
132* AR_25329375_ChIP-Seq_VCAP_Human0.91709079
133NANOG_16518401_ChIP-PET_MESCs_Mouse0.91174443
134IGF1R_20145208_ChIP-Seq_DFB_Human0.90923774
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90408655
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.90229330
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.90126342
138DCP1A_22483619_ChIP-Seq_HELA_Human0.90061632
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89516226
140ZFX_18555785_Chip-Seq_ESCs_Mouse0.89395061
141MYC_19829295_ChIP-Seq_ESCs_Human0.89095321
142SMAD4_21799915_ChIP-Seq_A2780_Human0.88604573
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88108604
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87362763
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86592439
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.86414570
147MYC_18940864_ChIP-ChIP_HL60_Human0.86194385
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.85865033
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84898573
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84855840
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83872517
152KLF4_18555785_Chip-Seq_ESCs_Mouse0.83705823
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.82972879
154KAP1_27257070_Chip-Seq_ESCs_Mouse0.82866519
155SMAD1_18555785_Chip-Seq_ESCs_Mouse0.82237691
156E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82172175
157ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82039314
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81959849
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79123030
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77168891
161VDR_23849224_ChIP-Seq_CD4+_Human0.77106029
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.76710071
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.76598843
164SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75415520
165CDX2_20551321_ChIP-Seq_CACO-2_Human0.75023767
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73934732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.14963776
2MP0008057_abnormal_DNA_replication3.64484445
3MP0003011_delayed_dark_adaptation3.26175666
4MP0005075_abnormal_melanosome_morpholog2.99730499
5MP0004264_abnormal_extraembryonic_tissu2.99497875
6MP0005394_taste/olfaction_phenotype2.89275411
7MP0005499_abnormal_olfactory_system2.89275411
8MP0003890_abnormal_embryonic-extraembry2.79622374
9MP0002277_abnormal_respiratory_mucosa2.68450690
10MP0002254_reproductive_system_inflammat2.67847706
11MP0000566_synostosis2.58623045
12MP0003136_yellow_coat_color2.52439426
13MP0003646_muscle_fatigue2.48054438
14MP0005551_abnormal_eye_electrophysiolog2.38108067
15MP0003121_genomic_imprinting2.33975285
16MP0002638_abnormal_pupillary_reflex2.29923782
17MP0004147_increased_porphyrin_level2.27891600
18MP0004381_abnormal_hair_follicle2.27846240
19MP0003787_abnormal_imprinting2.25473906
20MP0004957_abnormal_blastocyst_morpholog2.24278699
21MP0006072_abnormal_retinal_apoptosis2.18209194
22MP0005257_abnormal_intraocular_pressure2.17782865
23MP0008058_abnormal_DNA_repair2.16518979
24MP0002132_abnormal_respiratory_system2.13139465
25MP0003111_abnormal_nucleus_morphology2.11440688
26MP0000678_abnormal_parathyroid_gland2.07291979
27MP0003938_abnormal_ear_development2.06095359
28MP0010094_abnormal_chromosome_stability2.03479850
29MP0001984_abnormal_olfaction1.91438628
30MP0002837_dystrophic_cardiac_calcinosis1.89547942
31MP0003718_maternal_effect1.81539847
32MP0002160_abnormal_reproductive_system1.78680642
33MP0003077_abnormal_cell_cycle1.76678611
34MP0009046_muscle_twitch1.74192521
35MP0004043_abnormal_pH_regulation1.73508069
36MP0003122_maternal_imprinting1.67401703
37MP0008789_abnormal_olfactory_epithelium1.66778507
38MP0002332_abnormal_exercise_endurance1.63924300
39MP0003941_abnormal_skin_development1.63755993
40MP0003195_calcinosis1.63420640
41MP0002653_abnormal_ependyma_morphology1.55702697
42MP0003880_abnormal_central_pattern1.55320967
43MP0001293_anophthalmia1.53997974
44MP0003786_premature_aging1.53099825
45MP0000049_abnormal_middle_ear1.48190055
46MP0003315_abnormal_perineum_morphology1.46981692
47MP0001188_hyperpigmentation1.46284700
48MP0000569_abnormal_digit_pigmentation1.42437638
49MP0008875_abnormal_xenobiotic_pharmacok1.41521998
50MP0005646_abnormal_pituitary_gland1.40192956
51MP0003693_abnormal_embryo_hatching1.39677589
52MP0006035_abnormal_mitochondrial_morpho1.38104392
53MP0005248_abnormal_Harderian_gland1.37322365
54MP0005408_hypopigmentation1.36424359
55MP0001968_abnormal_touch/_nociception1.36194754
56MP0009745_abnormal_behavioral_response1.33733185
57MP0002102_abnormal_ear_morphology1.31958160
58MP0002736_abnormal_nociception_after1.30889763
59MP0008872_abnormal_physiological_respon1.27493574
60MP0002095_abnormal_skin_pigmentation1.25619531
61MP0001764_abnormal_homeostasis1.25014886
62MP0001324_abnormal_eye_pigmentation1.23361936
63MP0008932_abnormal_embryonic_tissue1.22518953
64MP0006276_abnormal_autonomic_nervous1.22368082
65MP0002272_abnormal_nervous_system1.21685529
66MP0000762_abnormal_tongue_morphology1.20495413
67MP0005379_endocrine/exocrine_gland_phen1.20036708
68MP0002138_abnormal_hepatobiliary_system1.16767717
69MP0002233_abnormal_nose_morphology1.16737934
70MP0001485_abnormal_pinna_reflex1.16380565
71MP0002932_abnormal_joint_morphology1.13945409
72MP0002249_abnormal_larynx_morphology1.12679981
73MP0005195_abnormal_posterior_eye1.11959570
74MP0005174_abnormal_tail_pigmentation1.10922053
75MP0005645_abnormal_hypothalamus_physiol1.10701270
76MP0001529_abnormal_vocalization1.09186624
77MP0002210_abnormal_sex_determination1.09088593
78MP0005380_embryogenesis_phenotype1.07501892
79MP0001672_abnormal_embryogenesis/_devel1.07501892
80MP0005187_abnormal_penis_morphology1.07277004
81MP0002396_abnormal_hematopoietic_system1.07037499
82MP0008007_abnormal_cellular_replicative1.06359962
83MP0004782_abnormal_surfactant_physiolog1.04514929
84MP0003937_abnormal_limbs/digits/tail_de1.01522725
85MP0002114_abnormal_axial_skeleton1.00226720
86MP0004133_heterotaxia0.99697337
87MP0001119_abnormal_female_reproductive0.98974043
88MP0002127_abnormal_cardiovascular_syste0.98876955
89MP0000490_abnormal_crypts_of0.97838761
90MP0004885_abnormal_endolymph0.97348621
91MP0001286_abnormal_eye_development0.97339935
92MP0006036_abnormal_mitochondrial_physio0.95811323
93MP0001145_abnormal_male_reproductive0.95111958
94MP0000372_irregular_coat_pigmentation0.93228787
95MP0004858_abnormal_nervous_system0.93219657
96MP0003755_abnormal_palate_morphology0.92512907
97MP0005391_vision/eye_phenotype0.91552248
98MP0008877_abnormal_DNA_methylation0.91050987
99MP0002092_abnormal_eye_morphology0.91009904
100MP0002557_abnormal_social/conspecific_i0.90124282
101MP0002751_abnormal_autonomic_nervous0.90113202
102MP0002928_abnormal_bile_duct0.89983763
103MP0008995_early_reproductive_senescence0.89689918
104MP0001929_abnormal_gametogenesis0.89561780
105MP0002572_abnormal_emotion/affect_behav0.88897901
106MP0002938_white_spotting0.88836897
107MP0000647_abnormal_sebaceous_gland0.88615336
108MP0000350_abnormal_cell_proliferation0.88541997
109MP0005377_hearing/vestibular/ear_phenot0.87968431
110MP0003878_abnormal_ear_physiology0.87968431
111MP0010030_abnormal_orbit_morphology0.87808471
112MP0001905_abnormal_dopamine_level0.87652807
113MP0002098_abnormal_vibrissa_morphology0.86874522
114MP0008775_abnormal_heart_ventricle0.86726429
115MP0000432_abnormal_head_morphology0.86720956
116MP0005253_abnormal_eye_physiology0.86327267
117MP0000026_abnormal_inner_ear0.86136710
118MP0000313_abnormal_cell_death0.85903981
119MP0002085_abnormal_embryonic_tissue0.85748551
120MP0003567_abnormal_fetal_cardiomyocyte0.85713519
121MP0006082_CNS_inflammation0.85191236
122MP0000538_abnormal_urinary_bladder0.79982354
123MP0003123_paternal_imprinting0.79928205
124MP0000383_abnormal_hair_follicle0.79907571
125MP0000653_abnormal_sex_gland0.79620161
126MP0001919_abnormal_reproductive_system0.77367674
127MP0002752_abnormal_somatic_nervous0.77290821
128MP0001346_abnormal_lacrimal_gland0.77115225
129MP0002282_abnormal_trachea_morphology0.75173571
130MP0003984_embryonic_growth_retardation0.75162351
131MP0002088_abnormal_embryonic_growth/wei0.75108678
132MP0000631_abnormal_neuroendocrine_gland0.74916145
133MP0000015_abnormal_ear_pigmentation0.74332855
134MP0001986_abnormal_taste_sensitivity0.73078504
135MP0003119_abnormal_digestive_system0.72995693
136MP0002116_abnormal_craniofacial_bone0.72749311
137MP0004142_abnormal_muscle_tone0.72632061
138MP0002067_abnormal_sensory_capabilities0.71667872
139MP0002090_abnormal_vision0.70786831
140MP0000427_abnormal_hair_cycle0.69398442
141MP0005389_reproductive_system_phenotype0.67435605
142MP0005508_abnormal_skeleton_morphology0.67132860
143MP0003698_abnormal_male_reproductive0.65467182
144MP0003935_abnormal_craniofacial_develop0.63652607
145MP0001486_abnormal_startle_reflex0.63628448
146MP0002163_abnormal_gland_morphology0.63592020
147MP0005670_abnormal_white_adipose0.62788707
148MP0005310_abnormal_salivary_gland0.62533879
149MP0005171_absent_coat_pigmentation0.62431403
150MP0005266_abnormal_metabolism0.61634097

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.38209279
2Chromsome breakage (HP:0040012)5.81888206
3Bilateral microphthalmos (HP:0007633)5.23935109
4Hypochromic microcytic anemia (HP:0004840)4.50093482
5Pancreatic cysts (HP:0001737)4.42141097
6Rib fusion (HP:0000902)4.19871663
7Pancreatic fibrosis (HP:0100732)4.03853186
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.97356104
9Hypoplasia of the fovea (HP:0007750)3.97356104
10Congenital stationary night blindness (HP:0007642)3.92674556
11True hermaphroditism (HP:0010459)3.80425718
12Anomalous pulmonary venous return (HP:0010772)3.76941585
13Nephroblastoma (Wilms tumor) (HP:0002667)3.70187991
14Molar tooth sign on MRI (HP:0002419)3.67007605
15Abnormality of midbrain morphology (HP:0002418)3.67007605
16Meckel diverticulum (HP:0002245)3.61981492
17Embryonal renal neoplasm (HP:0011794)3.42816061
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.40774127
19Microvesicular hepatic steatosis (HP:0001414)3.39336680
20Abnormality of the ileum (HP:0001549)3.38450990
21Nephronophthisis (HP:0000090)3.35216900
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.34312395
23Absent/shortened dynein arms (HP:0200106)3.34312395
24Abnormality of the pulmonary veins (HP:0011718)3.22705693
25Hepatoblastoma (HP:0002884)3.19325455
26Reduced antithrombin III activity (HP:0001976)3.13502042
27Abnormality of the preputium (HP:0100587)3.02675035
28Supernumerary spleens (HP:0009799)3.01385860
29Medial flaring of the eyebrow (HP:0010747)2.98865498
30Type I transferrin isoform profile (HP:0003642)2.96476974
31Abnormality of the fovea (HP:0000493)2.93293894
32Progressive external ophthalmoplegia (HP:0000590)2.91741519
33Bile duct proliferation (HP:0001408)2.88518939
34Abnormal biliary tract physiology (HP:0012439)2.88518939
35Rectal fistula (HP:0100590)2.88207975
36Rectovaginal fistula (HP:0000143)2.88207975
37Abnormality of the renal medulla (HP:0100957)2.87214734
38Abnormal lung lobation (HP:0002101)2.85206846
39Cystic liver disease (HP:0006706)2.84324450
40Partial duplication of thumb phalanx (HP:0009944)2.82757243
41Impulsivity (HP:0100710)2.80648793
42Pendular nystagmus (HP:0012043)2.76716028
43Abnormal respiratory epithelium morphology (HP:0012253)2.70559620
44Abnormal respiratory motile cilium morphology (HP:0005938)2.70559620
45Duplication of thumb phalanx (HP:0009942)2.69998652
46Rhabdomyosarcoma (HP:0002859)2.67716493
47Intestinal fistula (HP:0100819)2.67707251
48Abnormal ciliary motility (HP:0012262)2.66307253
49Abnormal respiratory motile cilium physiology (HP:0012261)2.63948619
50Upper limb muscle weakness (HP:0003484)2.62801724
513-Methylglutaconic aciduria (HP:0003535)2.57671971
52Bifid tongue (HP:0010297)2.57119272
53Type II lissencephaly (HP:0007260)2.54945675
54Duodenal stenosis (HP:0100867)2.54609282
55Small intestinal stenosis (HP:0012848)2.54609282
56Congenital primary aphakia (HP:0007707)2.53336643
57Abnormality of chromosome stability (HP:0003220)2.51966127
58Gait imbalance (HP:0002141)2.50524116
59Nephrogenic diabetes insipidus (HP:0009806)2.49298016
60Testicular atrophy (HP:0000029)2.48204532
61Abnormality of the renal cortex (HP:0011035)2.47760880
62Neoplasm of striated muscle (HP:0009728)2.46904410
63Abnormal rod and cone electroretinograms (HP:0008323)2.43450463
64Multiple enchondromatosis (HP:0005701)2.43347652
65Aplasia/Hypoplasia of the macula (HP:0008059)2.42766240
66Abnormality of the phalanges of the hallux (HP:0010057)2.41408021
67Horizontal nystagmus (HP:0000666)2.39024261
68Chronic hepatic failure (HP:0100626)2.38987388
69Breast hypoplasia (HP:0003187)2.38064434
70Abolished electroretinogram (ERG) (HP:0000550)2.37702380
71Anencephaly (HP:0002323)2.36331713
72Duplicated collecting system (HP:0000081)2.36312990
73Ependymoma (HP:0002888)2.35813690
74Methylmalonic acidemia (HP:0002912)2.34186399
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.30540474
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29685594
77Fused cervical vertebrae (HP:0002949)2.29350038
78Partial duplication of the phalanx of hand (HP:0009999)2.29142369
79Nasolacrimal duct obstruction (HP:0000579)2.28508856
80Cheilitis (HP:0100825)2.28476379
81Vaginal fistula (HP:0004320)2.28445123
82Abnormality of the renal collecting system (HP:0004742)2.28348725
83Bone marrow hypocellularity (HP:0005528)2.24871437
84Dyschromatopsia (HP:0007641)2.23631369
85Abnormality of the lower motor neuron (HP:0002366)2.21538326
86Facial cleft (HP:0002006)2.21104989
87Colon cancer (HP:0003003)2.20722028
88Sclerocornea (HP:0000647)2.20485776
89Triphalangeal thumb (HP:0001199)2.20395686
90Abnormality of the labia minora (HP:0012880)2.19945240
91Genital tract atresia (HP:0001827)2.19448639
92Vaginal atresia (HP:0000148)2.15940121
93Febrile seizures (HP:0002373)2.15576748
94Supernumerary bones of the axial skeleton (HP:0009144)2.14336267
95Clubbing of toes (HP:0100760)2.14106754
96Shawl scrotum (HP:0000049)2.13362399
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12623127
98Supernumerary ribs (HP:0005815)2.11028477
99Sloping forehead (HP:0000340)2.10956923
100Abnormality of the duodenum (HP:0002246)2.09907211
101Postaxial foot polydactyly (HP:0001830)2.09086360
102Postaxial hand polydactyly (HP:0001162)2.08647371
103Chronic bronchitis (HP:0004469)2.08444082
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08399525
105Congenital hepatic fibrosis (HP:0002612)2.07968205
106Decreased central vision (HP:0007663)2.06850032
107Increased IgM level (HP:0003496)2.06103709
108Hypoplasia of the pons (HP:0012110)2.05239457
109Embryonal neoplasm (HP:0002898)2.04120325
110Lissencephaly (HP:0001339)2.03468820
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.02104758
112Aplasia/hypoplasia of the humerus (HP:0006507)2.01541938
113Abnormality of the pons (HP:0007361)2.00939743
114Periauricular skin pits (HP:0100277)1.99956078
115Preauricular pit (HP:0004467)1.99956078
116Aplastic anemia (HP:0001915)1.99875229
117Attenuation of retinal blood vessels (HP:0007843)1.99125796
118Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98882887
119Poor coordination (HP:0002370)1.98759869
120Tubular atrophy (HP:0000092)1.97484771
121Atelectasis (HP:0100750)1.96910949
122Sensory axonal neuropathy (HP:0003390)1.95819604
123Occipital encephalocele (HP:0002085)1.95469791
124Rhinitis (HP:0012384)1.95361310
125Hyperglycinemia (HP:0002154)1.95300781
126Male pseudohermaphroditism (HP:0000037)1.94864994
127Increased CSF lactate (HP:0002490)1.94567923
128Progressive inability to walk (HP:0002505)1.94460379
129Abnormality of the salivary glands (HP:0010286)1.94099807
130Combined immunodeficiency (HP:0005387)1.93183021
131Abnormality of macular pigmentation (HP:0008002)1.92817490
132Absent radius (HP:0003974)1.92433501
133Patellar aplasia (HP:0006443)1.91611336
134Polydipsia (HP:0001959)1.91006150
135Abnormal drinking behavior (HP:0030082)1.91006150
136Hypochromic anemia (HP:0001931)1.90952214
137Hepatocellular necrosis (HP:0001404)1.90594109
138Oligodactyly (hands) (HP:0001180)1.90308405
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88817836
140Osteomalacia (HP:0002749)1.88625253
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88479607
142Myelodysplasia (HP:0002863)1.88224178
143Abnormality of DNA repair (HP:0003254)1.88049523
144Premature ovarian failure (HP:0008209)1.87961620
145Preaxial hand polydactyly (HP:0001177)1.87886446
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87633430
147Mitochondrial inheritance (HP:0001427)1.87595874
148Medulloblastoma (HP:0002885)1.86746120
149Absent thumb (HP:0009777)1.86666191
150Methylmalonic aciduria (HP:0012120)1.86277974
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86243740
152Short tibia (HP:0005736)1.84455899
153Hyperventilation (HP:0002883)1.84345164
154Ectopic kidney (HP:0000086)1.84203767
155Acute necrotizing encephalopathy (HP:0006965)1.83836569
156Furrowed tongue (HP:0000221)1.82616294
157Hepatic necrosis (HP:0002605)1.82128459
158Abnormality of the lacrimal duct (HP:0011481)1.80400430
159Aplasia involving forearm bones (HP:0009822)1.78989790
160Absent forearm bone (HP:0003953)1.78989790
161Septo-optic dysplasia (HP:0100842)1.78985039
162Hypergonadotropic hypogonadism (HP:0000815)1.77542547
163Astigmatism (HP:0000483)1.77520943
164Aplasia/Hypoplasia of the patella (HP:0006498)1.76546332
165Hemivertebrae (HP:0002937)1.76515236
166Abnormal glycosylation (HP:0012345)1.75926186
167Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75926186
168Abnormal protein N-linked glycosylation (HP:0012347)1.75926186
169Abnormal protein glycosylation (HP:0012346)1.75926186
170Acute encephalopathy (HP:0006846)1.74967804
171Median cleft lip (HP:0000161)1.74243798
172Increased corneal curvature (HP:0100692)1.73732112
173Keratoconus (HP:0000563)1.73732112
174Anophthalmia (HP:0000528)1.73324744
175Fibular aplasia (HP:0002990)1.71418764
176Aplasia/Hypoplasia of the spleen (HP:0010451)1.71221654
177Dandy-Walker malformation (HP:0001305)1.70928952
178Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67662257
179Birth length less than 3rd percentile (HP:0003561)1.67587421
180Chorioretinal atrophy (HP:0000533)1.67235887
181Inability to walk (HP:0002540)1.66497831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.00173644
2ADRBK24.08922170
3FRK3.77693922
4GRK53.74200781
5BMPR1B3.25401590
6GRK13.22022071
7TTK3.04033249
8MAP4K22.87127076
9WNK32.78015411
10EPHA22.69522047
11PRPF4B2.63761719
12GRK62.60262521
13TRIM282.57141825
14SRPK12.16329579
15GRK72.13372769
16AKT32.07178337
17ZAK2.01459416
18PLK41.98709881
19IRAK31.97152878
20MAP3K41.83503910
21MAPK71.83284845
22CSF1R1.77060978
23BRSK21.73178077
24CHEK21.70169233
25MOS1.69624765
26EIF2AK21.67735057
27WNK41.66216219
28CDK71.61793522
29INSRR1.58557204
30MKNK21.53669165
31OXSR11.53060897
32YES11.47713462
33CASK1.34632097
34PLK11.33713911
35CDK191.31506062
36TYRO31.23215547
37MARK31.22733486
38MST41.21010670
39STK101.20732077
40TNIK1.19834748
41PLK21.18733063
42ERN11.17229188
43EIF2AK31.16739469
44IRAK41.14265094
45TAF11.13616523
46BUB11.11556649
47BMPR21.10277628
48STK161.09004285
49PBK1.08443040
50WNK11.07609668
51TGFBR11.06945150
52MATK1.06690343
53BRD41.05981131
54DYRK21.05798550
55STK38L1.04375515
56BCR1.02013376
57NME11.00238545
58TSSK60.99695357
59TGFBR20.99306628
60FGFR20.97421587
61BRAF0.96536656
62TAOK30.94081218
63VRK20.88017811
64ERBB30.87782196
65CHEK10.84713683
66TXK0.82927524
67MAPK150.82902664
68STK390.80931660
69CSNK1G20.80288029
70CSNK1G30.80280159
71CSNK1G10.79593227
72ADRBK10.78380239
73MAP2K60.76322364
74SIK30.75993021
75PRKCE0.75060585
76IKBKB0.74834959
77MKNK10.74788914
78TNK20.74579411
79VRK10.73558043
80PRKCI0.72748313
81CDC70.72710224
82MARK20.71787833
83AURKA0.71574485
84CSNK1A1L0.70221046
85ATM0.69872523
86CAMK40.69634808
87PAK30.67374991
88BCKDK0.67373414
89DAPK20.65959524
90IRAK20.65703247
91TESK20.65478830
92CDK80.64387850
93PRKG20.63216030
94RPS6KA50.63164185
95HIPK20.59697024
96TLK10.58915715
97ATR0.58519172
98PLK30.58098846
99MAP2K40.55996502
100PRKCG0.55493744
101WEE10.55408988
102DYRK30.55067866
103PAK40.54985609
104DYRK1A0.52201808
105CAMKK20.51278505
106STK40.50343223
107RPS6KA40.49525776
108PRKCQ0.46934364
109MAPKAPK30.46419192
110MAP2K70.46203061
111CSNK1A10.46103538
112LATS20.45924400
113CSK0.43933381
114MAP3K60.43893260
115SYK0.43363473
116AURKB0.42989676
117SIK20.41911206
118MAPK130.39872896
119NLK0.39804532
120NTRK20.39391184
121PINK10.39135673
122FLT30.38234335
123IRAK10.38140737
124IKBKE0.37468877
125EPHA30.36987130
126FER0.36779945
127PRKD20.36736306
128NEK60.36363335
129CDK20.35985380
130MARK10.35877300
131PNCK0.35251791
132CAMK2A0.35181665
133MUSK0.34880272
134CDK10.34677526
135CSNK1E0.33828729
136AKT20.33519411
137NEK20.33286487
138CHUK0.32417760
139NEK10.32302195
140TEC0.31933385
141CSNK2A20.30769253
142CSNK2A10.30707186
143FGFR30.30432839
144MAP3K130.30161735
145ERBB40.29391235
146PRKCD0.28272483
147PAK10.27480495
148PKN10.27293026
149MELK0.26950932
150CDK40.26863231
151ACVR1B0.26142648
152NUAK10.25886124
153TAOK20.25373456
154LATS10.24798956
155GSK3B0.24027402
156CDK30.23396762
157PRKACA0.20056778
158MAPK140.19797661
159MAPK120.19441977

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.97240074
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07510431
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.92460542
4Fanconi anemia pathway_Homo sapiens_hsa034603.53365251
5Homologous recombination_Homo sapiens_hsa034402.96839733
6RNA polymerase_Homo sapiens_hsa030202.70058054
7Arachidonic acid metabolism_Homo sapiens_hsa005902.46094966
8Basal transcription factors_Homo sapiens_hsa030222.36680655
9Mismatch repair_Homo sapiens_hsa034302.29408132
10Linoleic acid metabolism_Homo sapiens_hsa005912.25997394
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23741095
12Protein export_Homo sapiens_hsa030602.13770591
13Oxidative phosphorylation_Homo sapiens_hsa001902.12723950
14DNA replication_Homo sapiens_hsa030302.12467792
15Non-homologous end-joining_Homo sapiens_hsa034502.09107833
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08161136
17Selenocompound metabolism_Homo sapiens_hsa004502.04373751
18RNA degradation_Homo sapiens_hsa030181.85155588
19Parkinsons disease_Homo sapiens_hsa050121.84455599
20Ribosome_Homo sapiens_hsa030101.72492828
21Pyrimidine metabolism_Homo sapiens_hsa002401.72276029
22Propanoate metabolism_Homo sapiens_hsa006401.70252282
23Nucleotide excision repair_Homo sapiens_hsa034201.62436886
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60205863
25Nitrogen metabolism_Homo sapiens_hsa009101.60081432
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59502916
27Fructose and mannose metabolism_Homo sapiens_hsa000511.58961912
28RNA transport_Homo sapiens_hsa030131.55709531
29Base excision repair_Homo sapiens_hsa034101.54868602
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48204425
31Spliceosome_Homo sapiens_hsa030401.47799621
32Cell cycle_Homo sapiens_hsa041101.44275797
33Ether lipid metabolism_Homo sapiens_hsa005651.43662529
34Butanoate metabolism_Homo sapiens_hsa006501.42844199
35mRNA surveillance pathway_Homo sapiens_hsa030151.34010005
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31255226
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30843127
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29393293
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26341996
40Tryptophan metabolism_Homo sapiens_hsa003801.24364814
41One carbon pool by folate_Homo sapiens_hsa006701.22134161
42Other glycan degradation_Homo sapiens_hsa005111.21577963
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19857768
44p53 signaling pathway_Homo sapiens_hsa041151.15177923
45Peroxisome_Homo sapiens_hsa041461.14384291
46Primary immunodeficiency_Homo sapiens_hsa053401.13284821
47Fatty acid elongation_Homo sapiens_hsa000621.13217915
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09011766
49Ovarian steroidogenesis_Homo sapiens_hsa049131.08588211
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08320112
51Caffeine metabolism_Homo sapiens_hsa002321.08239248
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.05435470
53Galactose metabolism_Homo sapiens_hsa000521.02809375
54Purine metabolism_Homo sapiens_hsa002301.00859736
55Olfactory transduction_Homo sapiens_hsa047401.00350505
56Alzheimers disease_Homo sapiens_hsa050100.99876601
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93669131
58Regulation of autophagy_Homo sapiens_hsa041400.91035599
59Sulfur metabolism_Homo sapiens_hsa009200.89831052
60Graft-versus-host disease_Homo sapiens_hsa053320.89448742
61Sphingolipid metabolism_Homo sapiens_hsa006000.87272226
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.86920821
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86333897
64Herpes simplex infection_Homo sapiens_hsa051680.83781711
65Proteasome_Homo sapiens_hsa030500.83596220
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83227260
67Taste transduction_Homo sapiens_hsa047420.81414138
68Retinol metabolism_Homo sapiens_hsa008300.80995816
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79577241
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78229355
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77400848
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77045111
73beta-Alanine metabolism_Homo sapiens_hsa004100.74841234
74Morphine addiction_Homo sapiens_hsa050320.73992249
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72138875
76Asthma_Homo sapiens_hsa053100.71533643
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71263614
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70628882
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68677197
80Chemical carcinogenesis_Homo sapiens_hsa052040.68577457
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68134561
82Autoimmune thyroid disease_Homo sapiens_hsa053200.67967120
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.66657681
84Phototransduction_Homo sapiens_hsa047440.66327481
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62066428
86Basal cell carcinoma_Homo sapiens_hsa052170.61346530
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61123130
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60820486
89Pyruvate metabolism_Homo sapiens_hsa006200.60497487
90Notch signaling pathway_Homo sapiens_hsa043300.58930377
91Glycerolipid metabolism_Homo sapiens_hsa005610.55916925
92Allograft rejection_Homo sapiens_hsa053300.54070252
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53658045
94Serotonergic synapse_Homo sapiens_hsa047260.53201386
95Cardiac muscle contraction_Homo sapiens_hsa042600.53193022
96Steroid biosynthesis_Homo sapiens_hsa001000.53053795
97Circadian rhythm_Homo sapiens_hsa047100.52792157
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.50509558
99African trypanosomiasis_Homo sapiens_hsa051430.50248418
100Nicotine addiction_Homo sapiens_hsa050330.47749193
101Folate biosynthesis_Homo sapiens_hsa007900.47580864
102Hematopoietic cell lineage_Homo sapiens_hsa046400.47210563
103Thyroid cancer_Homo sapiens_hsa052160.47079152
104Metabolic pathways_Homo sapiens_hsa011000.45661009
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45596521
106GABAergic synapse_Homo sapiens_hsa047270.42927635
107Sulfur relay system_Homo sapiens_hsa041220.42856261
108Oocyte meiosis_Homo sapiens_hsa041140.39207134
109Glutamatergic synapse_Homo sapiens_hsa047240.38630064
110Inositol phosphate metabolism_Homo sapiens_hsa005620.38480319
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38391674
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38377517
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.38270127
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36307573
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.35599259
116Lysine degradation_Homo sapiens_hsa003100.35494984
117Wnt signaling pathway_Homo sapiens_hsa043100.35022320
118Choline metabolism in cancer_Homo sapiens_hsa052310.33623491
119Measles_Homo sapiens_hsa051620.33010084
120ABC transporters_Homo sapiens_hsa020100.32925368
121Fatty acid degradation_Homo sapiens_hsa000710.31852066
122Pathways in cancer_Homo sapiens_hsa052000.30572814
123Type I diabetes mellitus_Homo sapiens_hsa049400.30423652
124Fatty acid metabolism_Homo sapiens_hsa012120.29792047
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.28060387
126Hedgehog signaling pathway_Homo sapiens_hsa043400.27603310
127Vitamin digestion and absorption_Homo sapiens_hsa049770.26134598
128MicroRNAs in cancer_Homo sapiens_hsa052060.25342503
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24331118
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.24149085
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22902968
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22487888
133Influenza A_Homo sapiens_hsa051640.21534009
134Ras signaling pathway_Homo sapiens_hsa040140.21282511
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21254743
136Apoptosis_Homo sapiens_hsa042100.20172242
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18422708
138Huntingtons disease_Homo sapiens_hsa050160.18402218
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18287341
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.17965493
141Tyrosine metabolism_Homo sapiens_hsa003500.17078467
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.15600562

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