SETBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)4.84441863
2axonal fasciculation (GO:0007413)4.36131994
3cerebral cortex radially oriented cell migration (GO:0021799)4.31336681
4central nervous system projection neuron axonogenesis (GO:0021952)4.20015970
5lateral sprouting from an epithelium (GO:0060601)4.14574883
6establishment of mitochondrion localization (GO:0051654)3.87608579
7neuron recognition (GO:0008038)3.84188001
8neuron projection extension involved in neuron projection guidance (GO:1902284)3.74321868
9axon extension involved in axon guidance (GO:0048846)3.74321868
10gamma-aminobutyric acid transport (GO:0015812)3.69357527
11planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67426583
12negative regulation of axon extension involved in axon guidance (GO:0048843)3.66135850
13synapse assembly (GO:0007416)3.61304902
14layer formation in cerebral cortex (GO:0021819)3.57063159
15dendrite morphogenesis (GO:0048813)3.51500227
16nonmotile primary cilium assembly (GO:0035058)3.51432342
17spinal cord development (GO:0021510)3.49425790
18neural tube formation (GO:0001841)3.49068343
19regulation of axon extension involved in axon guidance (GO:0048841)3.47634851
20negative regulation of oligodendrocyte differentiation (GO:0048715)3.45576516
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44806733
22startle response (GO:0001964)3.37251756
23negative regulation of axon guidance (GO:1902668)3.34783671
24locomotory exploration behavior (GO:0035641)3.31502885
25dendritic spine morphogenesis (GO:0060997)3.30608544
26neurotransmitter-gated ion channel clustering (GO:0072578)3.30444104
27retinal ganglion cell axon guidance (GO:0031290)3.30300935
28regulation of axon guidance (GO:1902667)3.29524735
29central nervous system neuron axonogenesis (GO:0021955)3.27153024
30behavioral response to nicotine (GO:0035095)3.26246071
31limb bud formation (GO:0060174)3.23489198
32auditory behavior (GO:0031223)3.21757759
33sympathetic nervous system development (GO:0048485)3.18276256
34calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.17553362
35cell migration in hindbrain (GO:0021535)3.15833552
36vocalization behavior (GO:0071625)3.14159395
37transmission of nerve impulse (GO:0019226)3.10979908
38forebrain neuron differentiation (GO:0021879)3.10036209
39axon extension (GO:0048675)3.09372403
40glial cell proliferation (GO:0014009)3.08927787
41response to auditory stimulus (GO:0010996)3.08488296
42neuron cell-cell adhesion (GO:0007158)3.07648646
43synaptic transmission, glutamatergic (GO:0035249)3.04378808
44mitochondrion transport along microtubule (GO:0047497)3.03306350
45establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03306350
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01929517
47artery development (GO:0060840)2.99889805
48cranial nerve morphogenesis (GO:0021602)2.99660615
49establishment of nucleus localization (GO:0040023)2.98649857
50craniofacial suture morphogenesis (GO:0097094)2.98464966
51regulation of development, heterochronic (GO:0040034)2.95426732
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93518550
53regulation of timing of cell differentiation (GO:0048505)2.92556904
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92350985
55camera-type eye morphogenesis (GO:0048593)2.90899596
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.89501925
57bone trabecula formation (GO:0060346)2.87646466
58inner ear receptor stereocilium organization (GO:0060122)2.85749973
59cerebellar granule cell differentiation (GO:0021707)2.85656152
60mechanosensory behavior (GO:0007638)2.84168144
61cornea development in camera-type eye (GO:0061303)2.83971128
62cardiac ventricle formation (GO:0003211)2.83756284
63synaptic vesicle docking involved in exocytosis (GO:0016081)2.83700858
64postsynaptic membrane organization (GO:0001941)2.83568962
65regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83037311
66neuronal action potential propagation (GO:0019227)2.82189990
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77836921
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76713271
69regulation of collateral sprouting (GO:0048670)2.74349788
70limb development (GO:0060173)2.73809954
71appendage development (GO:0048736)2.73809954
72synapse organization (GO:0050808)2.73699596
73exploration behavior (GO:0035640)2.72218520
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71421174
75protein localization to synapse (GO:0035418)2.70789935
76cerebral cortex cell migration (GO:0021795)2.70630191
77proximal/distal pattern formation (GO:0009954)2.70135319
78positive regulation of synapse maturation (GO:0090129)2.69168112
79regulation of glutamate receptor signaling pathway (GO:1900449)2.68938952
80innervation (GO:0060384)2.68715143
81regulation of respiratory system process (GO:0044065)2.68104431
82regulation of establishment of planar polarity (GO:0090175)2.66888724
83sequestering of extracellular ligand from receptor (GO:0035581)2.66097346
84pyrimidine nucleobase catabolic process (GO:0006208)2.65807688
85negative regulation of axon extension (GO:0030517)2.65184710
86mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.65080454
87positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.65080454
88reflex (GO:0060004)2.64813581
89negative regulation of catenin import into nucleus (GO:0035414)2.63847792
90presynaptic membrane assembly (GO:0097105)2.63605891
91neuron projection extension (GO:1990138)2.63065349
92intraciliary transport (GO:0042073)2.62683906
93cardiac chamber formation (GO:0003207)2.61521588
94regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60883524
95inner ear receptor cell development (GO:0060119)2.58849690
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.58490294
97regulation of translation, ncRNA-mediated (GO:0045974)2.58490294
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58490294
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57806181
100head development (GO:0060322)2.56811131
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56661857
102radial glial cell differentiation (GO:0060019)2.55089837
103negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55011334
104neuromuscular synaptic transmission (GO:0007274)2.54923543
105convergent extension (GO:0060026)2.54744352
106regulation of oligodendrocyte differentiation (GO:0048713)2.54633641
107negative chemotaxis (GO:0050919)2.53966801
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53586095
109glycosphingolipid biosynthetic process (GO:0006688)2.53218551
110hippocampus development (GO:0021766)2.52314440
111neuron-neuron synaptic transmission (GO:0007270)2.52237254
112regulation of synaptic transmission, glutamatergic (GO:0051966)2.50644481
113negative regulation of astrocyte differentiation (GO:0048712)2.50408802
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50063754
115cell proliferation in forebrain (GO:0021846)2.48404217
116negative regulation of dendrite development (GO:2000171)2.48296593
117gastrulation with mouth forming second (GO:0001702)2.48234720
118regulation of neuron migration (GO:2001222)2.48042101
119neuronal stem cell maintenance (GO:0097150)2.47572025
120cell differentiation involved in kidney development (GO:0061005)2.47044654
121positive regulation of neuroblast proliferation (GO:0002052)2.46114549
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.45418285
123positive regulation of synapse assembly (GO:0051965)2.45404596
124mesenchymal-epithelial cell signaling (GO:0060638)2.43381495
125anatomical structure arrangement (GO:0048532)2.43344321
126regulation of dendritic spine morphogenesis (GO:0061001)2.42897343
127hippo signaling (GO:0035329)2.41422473
128urinary tract smooth muscle contraction (GO:0014848)2.41366523
129cochlea development (GO:0090102)2.41067128
130neuron migration (GO:0001764)2.40405359
131metanephric mesenchyme development (GO:0072075)2.40302180
132glutamate receptor signaling pathway (GO:0007215)2.40208479
133dendrite development (GO:0016358)2.39369778
134membrane depolarization during action potential (GO:0086010)2.37825724
135presynaptic membrane organization (GO:0097090)2.37779373
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37658896
137non-canonical Wnt signaling pathway (GO:0035567)2.37268737
138adult walking behavior (GO:0007628)2.37093042
139regulation of synapse assembly (GO:0051963)2.36446909
140histone H3-K4 trimethylation (GO:0080182)2.36242957
141cerebral cortex neuron differentiation (GO:0021895)2.36031035
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35869440
143cerebellar Purkinje cell differentiation (GO:0021702)2.35323249
144synaptic vesicle maturation (GO:0016188)2.35288318
145regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35073969
146axonogenesis (GO:0007409)2.34665900
147apical protein localization (GO:0045176)2.34307223
148olfactory bulb development (GO:0021772)2.34225943
149establishment of planar polarity (GO:0001736)2.34077555
150establishment of tissue polarity (GO:0007164)2.34077555
151glutamate secretion (GO:0014047)2.33767525
152somite development (GO:0061053)2.31974162
153ganglion development (GO:0061548)2.31405547
154regulation of synapse structural plasticity (GO:0051823)2.31285769
155cochlea morphogenesis (GO:0090103)2.30756667
156cerebellum development (GO:0021549)2.30709457
157homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.30610258
158facial nerve structural organization (GO:0021612)2.30277508
159prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.29340242
160synaptic vesicle exocytosis (GO:0016079)2.29221989
161nucleus localization (GO:0051647)2.27867071
162cranial suture morphogenesis (GO:0060363)2.26725435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64665532
2GBX2_23144817_ChIP-Seq_PC3_Human3.11865639
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99846670
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71807695
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62472428
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.59938000
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57346154
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57346154
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56024232
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.52511174
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39717519
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34519284
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31447318
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28873124
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25927233
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.20720202
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03990585
18DROSHA_22980978_ChIP-Seq_HELA_Human2.02837875
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99619107
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.97208617
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91719447
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90394510
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89188302
24AR_21572438_ChIP-Seq_LNCaP_Human1.88281596
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87296117
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.81047301
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80864417
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80123261
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79486070
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77243689
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73114622
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70084207
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67776108
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66324604
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64679499
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59080521
37VDR_22108803_ChIP-Seq_LS180_Human1.57017016
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.56447639
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54343262
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.54209012
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53651136
42* RING1B_27294783_Chip-Seq_NPCs_Mouse1.50803308
43* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50214634
44EWS_26573619_Chip-Seq_HEK293_Human1.49644043
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47456150
46REST_21632747_ChIP-Seq_MESCs_Mouse1.47149255
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.45587074
48AHR_22903824_ChIP-Seq_MCF-7_Human1.43048550
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.42763354
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.42094939
51P300_19829295_ChIP-Seq_ESCs_Human1.41890697
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41701960
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41693994
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.40706049
55TP53_18474530_ChIP-ChIP_U2OS_Human1.40352174
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40026731
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39559845
58ZNF274_21170338_ChIP-Seq_K562_Hela1.38745331
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37570635
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37251881
61ER_23166858_ChIP-Seq_MCF-7_Human1.37152164
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36305802
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.34332662
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33860247
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33860247
66IGF1R_20145208_ChIP-Seq_DFB_Human1.33195497
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.33160624
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.32574008
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31950935
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30630824
71CBP_20019798_ChIP-Seq_JUKART_Human1.30630824
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30610951
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30044314
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29796459
75FUS_26573619_Chip-Seq_HEK293_Human1.29663616
76* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29296238
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28919461
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.28093541
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27106016
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26565143
81AR_19668381_ChIP-Seq_PC3_Human1.25393244
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25114920
83TP53_16413492_ChIP-PET_HCT116_Human1.23785930
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23589339
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23096471
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22926428
87AR_25329375_ChIP-Seq_VCAP_Human1.22647969
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22062411
89TAF15_26573619_Chip-Seq_HEK293_Human1.20456028
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20337147
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.20155967
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19936642
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.19400723
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19268362
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19051943
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.18005480
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16640295
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16584445
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.16493537
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16042681
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.14432089
102STAT3_23295773_ChIP-Seq_U87_Human1.13939422
103KDM2B_26808549_Chip-Seq_REH_Human1.12729683
104RNF2_27304074_Chip-Seq_NSC_Mouse1.11641686
105BCAT_22108803_ChIP-Seq_LS180_Human1.11020772
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09931765
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09766545
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09763573
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08930248
110* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08539382
111* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07785318
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07769380
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07750384
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07335879
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06529218
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05950473
117* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04945578
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04914953
119SOX9_26525672_Chip-Seq_HEART_Mouse1.04792987
120* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04767978
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04520797
122TCF4_22108803_ChIP-Seq_LS180_Human1.04137561
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03963920
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.03780245
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03295388
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.02448673
127SMAD_19615063_ChIP-ChIP_OVARY_Human1.02373828
128* TCF4_23295773_ChIP-Seq_U87_Human1.01556113
129* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01308457
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00440646
131* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00161312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis2.97674760
2MP0004859_abnormal_synaptic_plasticity2.96420886
3MP0010030_abnormal_orbit_morphology2.92143057
4MP0002822_catalepsy2.81990298
5MP0000778_abnormal_nervous_system2.48821236
6MP0005248_abnormal_Harderian_gland2.45126402
7MP0003880_abnormal_central_pattern2.35582891
8MP0006292_abnormal_olfactory_placode2.22247153
9MP0005503_abnormal_tendon_morphology2.20861234
10MP0002735_abnormal_chemical_nociception2.17133943
11MP0002736_abnormal_nociception_after2.13921499
12MP0008789_abnormal_olfactory_epithelium2.07110083
13MP0003385_abnormal_body_wall2.00042119
14MP0009053_abnormal_anal_canal1.98479248
15MP0002638_abnormal_pupillary_reflex1.97516039
16MP0000569_abnormal_digit_pigmentation1.97320573
17MP0001529_abnormal_vocalization1.96427051
18MP0008438_abnormal_cutaneous_collagen1.94831981
19MP0000537_abnormal_urethra_morphology1.91863538
20MP0009780_abnormal_chondrocyte_physiolo1.89577011
21MP0000049_abnormal_middle_ear1.88996770
22MP0006276_abnormal_autonomic_nervous1.86691367
23MP0005499_abnormal_olfactory_system1.85535147
24MP0005394_taste/olfaction_phenotype1.85535147
25MP0003122_maternal_imprinting1.85417588
26MP0003635_abnormal_synaptic_transmissio1.85331383
27MP0002272_abnormal_nervous_system1.79221546
28MP0009250_abnormal_appendicular_skeleto1.79116300
29MP0002249_abnormal_larynx_morphology1.78348603
30MP0004270_analgesia1.73896891
31MP0002102_abnormal_ear_morphology1.72183255
32MP0001299_abnormal_eye_distance/1.71070740
33MP0002938_white_spotting1.70982870
34MP0003755_abnormal_palate_morphology1.70780792
35MP0002184_abnormal_innervation1.69794391
36MP0000428_abnormal_craniofacial_morphol1.66666318
37MP0002653_abnormal_ependyma_morphology1.61588597
38MP0002063_abnormal_learning/memory/cond1.59166577
39MP0005187_abnormal_penis_morphology1.57909101
40MP0003938_abnormal_ear_development1.55252713
41MP0003942_abnormal_urinary_system1.53235615
42MP0000631_abnormal_neuroendocrine_gland1.52899151
43MP0002233_abnormal_nose_morphology1.50017257
44MP0000534_abnormal_ureter_morphology1.49318825
45MP0004924_abnormal_behavior1.49115549
46MP0005386_behavior/neurological_phenoty1.49115549
47MP0004142_abnormal_muscle_tone1.44551282
48MP0003935_abnormal_craniofacial_develop1.44074114
49MP0003787_abnormal_imprinting1.42890192
50MP0003136_yellow_coat_color1.42692701
51MP0003937_abnormal_limbs/digits/tail_de1.42009044
52MP0002116_abnormal_craniofacial_bone1.41563261
53MP0005253_abnormal_eye_physiology1.40669903
54MP0005551_abnormal_eye_electrophysiolog1.38871948
55MP0005645_abnormal_hypothalamus_physiol1.36769010
56MP0001486_abnormal_startle_reflex1.34663324
57MP0002733_abnormal_thermal_nociception1.34548188
58MP0005423_abnormal_somatic_nervous1.31712495
59MP0001970_abnormal_pain_threshold1.30669301
60MP0001984_abnormal_olfaction1.30521199
61MP0003283_abnormal_digestive_organ1.29517817
62MP0002909_abnormal_adrenal_gland1.28070599
63MP0002234_abnormal_pharynx_morphology1.27947286
64MP0002932_abnormal_joint_morphology1.27160016
65MP0003011_delayed_dark_adaptation1.27145155
66MP0005275_abnormal_skin_tensile1.24827498
67MP0003861_abnormal_nervous_system1.24805521
68MP0006072_abnormal_retinal_apoptosis1.24270870
69MP0004885_abnormal_endolymph1.20773224
70MP0002282_abnormal_trachea_morphology1.20621153
71MP0004134_abnormal_chest_morphology1.20600467
72MP0004133_heterotaxia1.20048723
73MP0002752_abnormal_somatic_nervous1.19661403
74MP0005257_abnormal_intraocular_pressure1.19519967
75MP0003115_abnormal_respiratory_system1.19099652
76MP0002177_abnormal_outer_ear1.19065479
77MP0004742_abnormal_vestibular_system1.18518044
78MP0003121_genomic_imprinting1.17958041
79MP0004858_abnormal_nervous_system1.17824535
80MP0001502_abnormal_circadian_rhythm1.17112062
81MP0009745_abnormal_behavioral_response1.14774987
82MP0005623_abnormal_meninges_morphology1.14406261
83MP0000579_abnormal_nail_morphology1.13630875
84MP0002572_abnormal_emotion/affect_behav1.12531458
85MP0000955_abnormal_spinal_cord1.12391899
86MP0002896_abnormal_bone_mineralization1.09825735
87MP0005508_abnormal_skeleton_morphology1.09815761
88MP0002108_abnormal_muscle_morphology1.09774340
89MP0001293_anophthalmia1.09198051
90MP0000751_myopathy1.09060728
91MP0008877_abnormal_DNA_methylation1.08290707
92MP0002557_abnormal_social/conspecific_i1.07247403
93MP0002152_abnormal_brain_morphology1.07067877
94MP0000516_abnormal_urinary_system1.06464163
95MP0005367_renal/urinary_system_phenotyp1.06464163
96MP0002751_abnormal_autonomic_nervous1.06423995
97MP0000026_abnormal_inner_ear1.04975917
98MP0001485_abnormal_pinna_reflex1.04752149
99MP0002882_abnormal_neuron_morphology1.04128870
100MP0004811_abnormal_neuron_physiology1.04006884
101MP0001501_abnormal_sleep_pattern1.01502972
102MP0002734_abnormal_mechanical_nocicepti1.01140020
103MP0009384_cardiac_valve_regurgitation1.00591549
104MP0003705_abnormal_hypodermis_morpholog0.99598347
105MP0002064_seizures0.98506817
106MP0000432_abnormal_head_morphology0.98308534
107MP0003119_abnormal_digestive_system0.97885985
108MP0001188_hyperpigmentation0.96103764
109MP0001958_emphysema0.95709286
110MP0001968_abnormal_touch/_nociception0.94862420
111MP0001177_atelectasis0.94712804
112MP0002066_abnormal_motor_capabilities/c0.94237027
113MP0001963_abnormal_hearing_physiology0.93023729
114MP0002067_abnormal_sensory_capabilities0.90096203
115MP0002081_perinatal_lethality0.89782820
116MP0003890_abnormal_embryonic-extraembry0.88055959
117MP0005391_vision/eye_phenotype0.87881078
118MP0000163_abnormal_cartilage_morphology0.87718241
119MP0005195_abnormal_posterior_eye0.87372401
120MP0009046_muscle_twitch0.87285377
121MP0001270_distended_abdomen0.87212962
122MP0002114_abnormal_axial_skeleton0.86870006
123MP0004145_abnormal_muscle_electrophysio0.86675756
124MP0002109_abnormal_limb_morphology0.86625736
125MP0000733_abnormal_muscle_development0.86586141
126MP0001340_abnormal_eyelid_morphology0.86556600
127MP0004272_abnormal_basement_membrane0.85255410
128MP0008569_lethality_at_weaning0.84026524
129MP0003195_calcinosis0.83997374
130MP0004233_abnormal_muscle_weight0.82818306
131MP0002928_abnormal_bile_duct0.82775737
132MP0000647_abnormal_sebaceous_gland0.81266099
133MP0003137_abnormal_impulse_conducting0.81137841
134MP0005076_abnormal_cell_differentiation0.79001067
135MP0005646_abnormal_pituitary_gland0.78996601
136MP0004043_abnormal_pH_regulation0.78948263
137MP0000762_abnormal_tongue_morphology0.78213354
138MP0002069_abnormal_eating/drinking_beha0.77535448
139MP0005171_absent_coat_pigmentation0.77284986

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.18934804
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.18934804
3Abnormality of the 4th metacarpal (HP:0010012)3.84863777
4* Shallow orbits (HP:0000586)3.07058504
5Absent speech (HP:0001344)3.03835689
6Intestinal atresia (HP:0011100)2.93313324
7Trigonocephaly (HP:0000243)2.89057145
8Oligodactyly (hands) (HP:0001180)2.85820625
9Microglossia (HP:0000171)2.76448868
10Gait imbalance (HP:0002141)2.75691187
11Midline defect of the nose (HP:0004122)2.74705528
12True hermaphroditism (HP:0010459)2.68757513
13Broad metatarsal (HP:0001783)2.63275803
14Medial flaring of the eyebrow (HP:0010747)2.61278324
15Nephronophthisis (HP:0000090)2.60808076
16Abnormality of the aortic arch (HP:0012303)2.58178084
17Oligodactyly (HP:0012165)2.48913526
18Abnormality of the phalanges of the hallux (HP:0010057)2.47646984
19Congenital primary aphakia (HP:0007707)2.44664784
20Genital tract atresia (HP:0001827)2.43151476
21Pancreatic cysts (HP:0001737)2.42825217
22Hemiparesis (HP:0001269)2.42189401
23Abnormality of the diencephalon (HP:0010662)2.39431273
24Pachygyria (HP:0001302)2.39085034
25Abnormality of the renal medulla (HP:0100957)2.38506328
26Vaginal atresia (HP:0000148)2.37383558
27Pancreatic fibrosis (HP:0100732)2.35955126
28Lissencephaly (HP:0001339)2.35217922
29Aqueductal stenosis (HP:0002410)2.31736736
30Optic nerve hypoplasia (HP:0000609)2.29855978
31Broad toe (HP:0001837)2.29843301
32Polyphagia (HP:0002591)2.28165620
33Gaze-evoked nystagmus (HP:0000640)2.27956630
34Protruding tongue (HP:0010808)2.27763945
35Chronic hepatic failure (HP:0100626)2.27489590
36Cupped ear (HP:0000378)2.27476384
37Broad hallux (HP:0010055)2.27127098
38Nephrogenic diabetes insipidus (HP:0009806)2.25694953
39Coronal craniosynostosis (HP:0004440)2.22739912
40Morphological abnormality of the middle ear (HP:0008609)2.22637635
41Protrusio acetabuli (HP:0003179)2.21581907
42Limb dystonia (HP:0002451)2.16917999
43Cutaneous finger syndactyly (HP:0010554)2.16387352
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.16287151
45Poor coordination (HP:0002370)2.14261861
46Broad thumb (HP:0011304)2.13275091
47Abnormality of the parietal bone (HP:0002696)2.12143364
48Renal hypoplasia (HP:0000089)2.11096184
49Macroorchidism (HP:0000053)2.10676370
50Molar tooth sign on MRI (HP:0002419)2.10232721
51Abnormality of midbrain morphology (HP:0002418)2.10232721
52Widely spaced teeth (HP:0000687)2.09949604
53Aplasia involving bones of the upper limbs (HP:0009823)2.09617249
54Aplasia of the phalanges of the hand (HP:0009802)2.09617249
55Aplasia involving bones of the extremities (HP:0009825)2.09617249
56Overgrowth (HP:0001548)2.06610043
57Specific learning disability (HP:0001328)2.05816208
58Narrow palate (HP:0000189)2.05779282
59Renal duplication (HP:0000075)2.05754612
60Septo-optic dysplasia (HP:0100842)2.05597172
61Agitation (HP:0000713)2.05022841
62Amyotrophic lateral sclerosis (HP:0007354)2.03683040
63Focal motor seizures (HP:0011153)2.02824085
64Bell-shaped thorax (HP:0001591)2.01944829
65Asymmetry of the thorax (HP:0001555)2.01917946
66Abnormality of the ischium (HP:0003174)2.01599742
67Focal seizures (HP:0007359)1.97691063
68Retinal dysplasia (HP:0007973)1.97436603
69Hyperventilation (HP:0002883)1.97229277
70* Postaxial hand polydactyly (HP:0001162)1.97103321
71Narrow nasal bridge (HP:0000446)1.95160383
72Excessive salivation (HP:0003781)1.94655133
73Drooling (HP:0002307)1.94655133
74Atonic seizures (HP:0010819)1.94068561
75Broad long bones (HP:0005622)1.93121303
76Natal tooth (HP:0000695)1.92674540
77Bladder diverticulum (HP:0000015)1.92375509
78Broad finger (HP:0001500)1.92304881
79Broad phalanx (HP:0006009)1.90451757
80Inability to walk (HP:0002540)1.89459392
81Broad-based gait (HP:0002136)1.88301515
82Broad phalanges of the hand (HP:0009768)1.88203460
83Buphthalmos (HP:0000557)1.87956055
84Myokymia (HP:0002411)1.87886777
85Hypoplasia of the maxilla (HP:0000327)1.87153729
86Broad alveolar ridges (HP:0000187)1.86812867
87Anencephaly (HP:0002323)1.86533870
88Hypoplastic iliac wings (HP:0002866)1.85867040
89Abnormality of the antihelix (HP:0009738)1.85382554
90Advanced eruption of teeth (HP:0006288)1.84798072
91Chorioretinal atrophy (HP:0000533)1.84457231
92* Hypsarrhythmia (HP:0002521)1.84455028
93Cutaneous syndactyly (HP:0012725)1.84195729
94Megalencephaly (HP:0001355)1.83367990
95Vitreoretinal degeneration (HP:0000655)1.83265968
96Epileptic encephalopathy (HP:0200134)1.83031840
97Abnormal hair whorl (HP:0010721)1.82510516
98Obstructive sleep apnea (HP:0002870)1.82272884
99Patellar aplasia (HP:0006443)1.81709727
100* EEG with generalized epileptiform discharges (HP:0011198)1.81540292
101Preaxial foot polydactyly (HP:0001841)1.81052049
102* Epileptiform EEG discharges (HP:0011182)1.80338048
103Aortic aneurysm (HP:0004942)1.77502567
104Wide anterior fontanel (HP:0000260)1.77218178
105Elfin facies (HP:0004428)1.76857378
106Cystic liver disease (HP:0006706)1.76209811
107Deviation of the hallux (HP:0010051)1.76191719
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76020456
109Dialeptic seizures (HP:0011146)1.75869073
110Flat cornea (HP:0007720)1.75768179
111Abnormality of salivation (HP:0100755)1.75593469
112Adactyly (HP:0009776)1.75264010
113Renovascular hypertension (HP:0100817)1.74965406
114Omphalocele (HP:0001539)1.74285522
115Neoplasm of the heart (HP:0100544)1.74263459
116Abnormality of the intervertebral disk (HP:0005108)1.73877333
117Abnormality of the nasal septum (HP:0000419)1.73715463
118Neonatal short-limb short stature (HP:0008921)1.73546606
119Bronchomalacia (HP:0002780)1.73499405
120Split foot (HP:0001839)1.73429969
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.72662530
122Aortic dissection (HP:0002647)1.72380371
123Thyroid-stimulating hormone excess (HP:0002925)1.71236737
124Anteriorly placed anus (HP:0001545)1.71199746
125* Narrow forehead (HP:0000341)1.71055080
126* Aplasia/Hypoplasia of the sternum (HP:0006714)1.71001951
127Gastrointestinal atresia (HP:0002589)1.70980824
128* Micropenis (HP:0000054)1.70826573
129Vascular tortuosity (HP:0004948)1.70245984
130Truncal obesity (HP:0001956)1.70167443
131Genetic anticipation (HP:0003743)1.69923286
132Neoplasm of the oral cavity (HP:0100649)1.69561956
133Arterial tortuosity (HP:0005116)1.68660803
134Exotropia (HP:0000577)1.67989637
135Hypoventilation (HP:0002791)1.67813448
136Blue irides (HP:0000635)1.67664977
137Obsessive-compulsive behavior (HP:0000722)1.67265183
138* Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67017487
139* Short foot (HP:0001773)1.66875981
140* Hepatoblastoma (HP:0002884)1.66445379
141Postaxial foot polydactyly (HP:0001830)1.66294626
142Increased corneal curvature (HP:0100692)1.64878125
143Keratoconus (HP:0000563)1.64878125
144Turricephaly (HP:0000262)1.64863428
145Shawl scrotum (HP:0000049)1.63928242
146Hallux valgus (HP:0001822)1.63660681
147Abnormality of the lower motor neuron (HP:0002366)1.63470746
148Aplasia/Hypoplasia of the patella (HP:0006498)1.63215789
149* Alacrima (HP:0000522)1.63077310
150Progressive cerebellar ataxia (HP:0002073)1.62406236
151Exostoses (HP:0100777)1.62097090
152Anophthalmia (HP:0000528)1.60723077
153Bowel diverticulosis (HP:0005222)1.60396635
154Premature rupture of membranes (HP:0001788)1.59675086
155Febrile seizures (HP:0002373)1.59323588
156Absent frontal sinuses (HP:0002688)1.57378199
157Tented upper lip vermilion (HP:0010804)1.57316541
158Wrist flexion contracture (HP:0001239)1.56320462
159Growth hormone deficiency (HP:0000824)1.55986903
160Enlarged penis (HP:0000040)1.55921106
161Volvulus (HP:0002580)1.55770472
162Hyperacusis (HP:0010780)1.55400688
163* Broad ribs (HP:0000885)1.55055550
164Hypoplastic ischia (HP:0003175)1.54446863
165Hyperextensible skin (HP:0000974)1.54138805
166Benign neoplasm of the central nervous system (HP:0100835)1.53790813
167Increased number of teeth (HP:0011069)1.52209650
168Tracheomalacia (HP:0002779)1.52196988
169Dental malocclusion (HP:0000689)1.51633949
170Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.51450434
171Syringomyelia (HP:0003396)1.51253122
172Spinal cord lesions (HP:0100561)1.51253122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.64092356
2MAP4K22.98322342
3EPHA42.87466560
4WNK32.84055469
5LATS12.78564744
6PINK12.71249063
7NTRK32.67311320
8EPHB22.57076243
9CASK2.47288533
10DDR22.39035424
11FGFR22.16695605
12ERBB32.12467290
13SIK22.08263614
14KSR12.03117973
15CAMK1G1.91998316
16MAPK131.91313754
17MAP3K41.87761704
18PDGFRA1.81511153
19NTRK21.71695292
20INSRR1.60671014
21SIK11.50671198
22TRIM281.47982489
23PLK21.46205551
24PRKD31.45224565
25DMPK1.44309033
26PHKG11.43900998
27PHKG21.43900998
28DAPK21.35573915
29PNCK1.35334205
30NUAK11.29882893
31MINK11.27402488
32SGK21.24044302
33PRPF4B1.23090181
34PAK61.22347227
35MAP3K91.20934421
36DYRK21.20514580
37LATS21.20309679
38OBSCN1.19483961
39MAP2K71.17798117
40PAK31.12255907
41FGFR11.08260967
42CSNK1G11.06338900
43CAMK1D1.05285609
44UHMK11.04906753
45BMPR1B1.04052227
46EPHA31.02889749
47FRK0.99497526
48SGK30.99453274
49CSNK1G30.98575388
50SGK2230.98278856
51SGK4940.98278856
52CDK50.93091813
53BRD40.91868157
54FER0.91559814
55GRK10.91534140
56ICK0.91216877
57PRKCH0.87186024
58ADRBK20.85937254
59DYRK1B0.85041161
60CSNK1A1L0.84371566
61CDC42BPA0.83307297
62SIK30.80432108
63ROCK10.79009191
64AKT30.78895719
65MAPK150.78835083
66DYRK1A0.78130988
67CSNK1G20.77835474
68CAMK40.77298030
69TNIK0.75192721
70PDGFRB0.75092652
71MARK20.74957659
72TTN0.74688802
73STK38L0.74313912
74LMTK20.73554344
75TYRO30.73508583
76STK110.73374497
77CCNB10.70358340
78RIPK10.69083015
79NTRK10.68625380
80PRKCG0.68385101
81FGFR30.68353688
82SGK10.67210205
83PRKCE0.65147851
84PIK3CA0.65008250
85RPS6KA20.64430442
86MKNK20.63695010
87CAMKK10.63585698
88TRIB30.62480125
89MAP3K60.61335394
90ERBB20.60835677
91PRKCZ0.60498139
92BCR0.59673359
93RET0.59186688
94PRKAA10.59158999
95MKNK10.58001521
96CDK30.57803448
97STK380.56538828
98CAMK2A0.54582533
99CSNK1D0.54307338
100CDK120.53585344
101PTK20.53408307
102CAMK2B0.53127059
103MAP2K40.53117979
104STK390.52595600
105MAP3K100.51550680
106DYRK30.51200083
107MTOR0.51158021
108ROCK20.48519263
109MAP3K70.46314073
110HIPK20.45427359
111CDK180.42723226
112PRKG10.42716817
113PRKACA0.42476526
114CAMK10.42226503
115MAPK80.42043445
116CSNK1A10.41975609
117MAPK90.39817753
118PRKACB0.39808251
119PTK60.39590010
120PKN10.39359248
121MAPK100.39260032
122GSK3B0.39052643
123WNK40.38872473
124CDK150.38412657
125RPS6KA30.38344344
126CAMKK20.36459866
127TIE10.34717411
128CSNK1E0.31734177
129CAMK2D0.31728244
130OXSR10.30232382
131CAMK2G0.29906770
132YES10.28778547
133TGFBR10.28103462

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.95987458
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47501973
3Axon guidance_Homo sapiens_hsa043602.23652131
4Nicotine addiction_Homo sapiens_hsa050332.22586293
5Basal cell carcinoma_Homo sapiens_hsa052172.13641656
6Butanoate metabolism_Homo sapiens_hsa006502.08304236
7Circadian entrainment_Homo sapiens_hsa047132.02198875
8Long-term potentiation_Homo sapiens_hsa047201.92346123
9Hedgehog signaling pathway_Homo sapiens_hsa043401.85895267
10Glutamatergic synapse_Homo sapiens_hsa047241.80384905
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71438346
12Olfactory transduction_Homo sapiens_hsa047401.69403987
13Amphetamine addiction_Homo sapiens_hsa050311.63464796
14Dopaminergic synapse_Homo sapiens_hsa047281.61821315
15Morphine addiction_Homo sapiens_hsa050321.59039201
16Insulin secretion_Homo sapiens_hsa049111.55723975
17Wnt signaling pathway_Homo sapiens_hsa043101.55458566
18GABAergic synapse_Homo sapiens_hsa047271.51406450
19Cholinergic synapse_Homo sapiens_hsa047251.50697239
20Melanogenesis_Homo sapiens_hsa049161.48792366
21Renin secretion_Homo sapiens_hsa049241.47454196
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47105366
23Steroid biosynthesis_Homo sapiens_hsa001001.46146597
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45516990
25Dilated cardiomyopathy_Homo sapiens_hsa054141.44508436
26Salivary secretion_Homo sapiens_hsa049701.43080200
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41933742
28Hippo signaling pathway_Homo sapiens_hsa043901.40052924
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39864452
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38552622
31Gap junction_Homo sapiens_hsa045401.36476265
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36406225
33Glioma_Homo sapiens_hsa052141.35685476
34Taste transduction_Homo sapiens_hsa047421.35673262
35Oxytocin signaling pathway_Homo sapiens_hsa049211.32780597
36Gastric acid secretion_Homo sapiens_hsa049711.32548215
37Cocaine addiction_Homo sapiens_hsa050301.31535567
38Long-term depression_Homo sapiens_hsa047301.30698543
39Type II diabetes mellitus_Homo sapiens_hsa049301.29851164
40cAMP signaling pathway_Homo sapiens_hsa040241.27003069
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26136830
42Colorectal cancer_Homo sapiens_hsa052101.25569652
43Synaptic vesicle cycle_Homo sapiens_hsa047211.24749551
44ErbB signaling pathway_Homo sapiens_hsa040121.24283705
45Endometrial cancer_Homo sapiens_hsa052131.24057687
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22904852
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22314235
48Adherens junction_Homo sapiens_hsa045201.21357695
49GnRH signaling pathway_Homo sapiens_hsa049121.20926974
50Estrogen signaling pathway_Homo sapiens_hsa049151.19232481
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18890216
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15507865
53Calcium signaling pathway_Homo sapiens_hsa040201.14278838
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11108678
55Serotonergic synapse_Homo sapiens_hsa047261.10968812
56Focal adhesion_Homo sapiens_hsa045101.09927587
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09281922
58Dorso-ventral axis formation_Homo sapiens_hsa043201.06624703
59Proteoglycans in cancer_Homo sapiens_hsa052051.05650234
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04236698
61Propanoate metabolism_Homo sapiens_hsa006401.02505610
62ECM-receptor interaction_Homo sapiens_hsa045121.01479856
63Renal cell carcinoma_Homo sapiens_hsa052111.01390454
64Linoleic acid metabolism_Homo sapiens_hsa005911.00608900
65Notch signaling pathway_Homo sapiens_hsa043300.97299469
66mTOR signaling pathway_Homo sapiens_hsa041500.96800204
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95685036
68MicroRNAs in cancer_Homo sapiens_hsa052060.95635845
69Melanoma_Homo sapiens_hsa052180.95411699
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94381820
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93040011
72Rap1 signaling pathway_Homo sapiens_hsa040150.92603554
73MAPK signaling pathway_Homo sapiens_hsa040100.90766655
74TGF-beta signaling pathway_Homo sapiens_hsa043500.90591479
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.88946577
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88765248
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.88675016
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88207799
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.88119602
80Choline metabolism in cancer_Homo sapiens_hsa052310.85307444
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85019633
82Basal transcription factors_Homo sapiens_hsa030220.82659736
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82515859
84Prostate cancer_Homo sapiens_hsa052150.82083857
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81859419
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81324154
87Protein export_Homo sapiens_hsa030600.80957223
88ABC transporters_Homo sapiens_hsa020100.80647622
89Chronic myeloid leukemia_Homo sapiens_hsa052200.80406740
90Nitrogen metabolism_Homo sapiens_hsa009100.79024202
91Pathways in cancer_Homo sapiens_hsa052000.77262020
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.76826439
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76703942
94Ras signaling pathway_Homo sapiens_hsa040140.75672507
95AMPK signaling pathway_Homo sapiens_hsa041520.75502203
96Viral myocarditis_Homo sapiens_hsa054160.75437800
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73810434
98Non-small cell lung cancer_Homo sapiens_hsa052230.73791040
99Cardiac muscle contraction_Homo sapiens_hsa042600.73729409
100Phototransduction_Homo sapiens_hsa047440.72961122
101Glucagon signaling pathway_Homo sapiens_hsa049220.71998611
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71877605
103Ether lipid metabolism_Homo sapiens_hsa005650.71156089
104Tight junction_Homo sapiens_hsa045300.69914214
105Regulation of autophagy_Homo sapiens_hsa041400.69597887
106Lysine degradation_Homo sapiens_hsa003100.68945395
107Insulin signaling pathway_Homo sapiens_hsa049100.67790231
108Protein digestion and absorption_Homo sapiens_hsa049740.67032709
109Thyroid hormone synthesis_Homo sapiens_hsa049180.66965733
110Pancreatic cancer_Homo sapiens_hsa052120.66406156
111Oocyte meiosis_Homo sapiens_hsa041140.65517328
112Fatty acid biosynthesis_Homo sapiens_hsa000610.64686166
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64335363
114Circadian rhythm_Homo sapiens_hsa047100.63359703
115FoxO signaling pathway_Homo sapiens_hsa040680.62759075
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61619641
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61584278
118Ovarian steroidogenesis_Homo sapiens_hsa049130.61023571
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59513573
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58163513
121VEGF signaling pathway_Homo sapiens_hsa043700.57591359
122Amoebiasis_Homo sapiens_hsa051460.57570299
123Pancreatic secretion_Homo sapiens_hsa049720.55982814
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54840021
125Fanconi anemia pathway_Homo sapiens_hsa034600.48315052
126Alcoholism_Homo sapiens_hsa050340.47337836
127beta-Alanine metabolism_Homo sapiens_hsa004100.45762426
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45142492
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44747263
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44300906
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.42944317

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