SERPINF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.36401873
2L-phenylalanine catabolic process (GO:0006559)6.36401873
3L-phenylalanine metabolic process (GO:0006558)6.23024373
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.23024373
5negative regulation of fibrinolysis (GO:0051918)5.95817850
6protein carboxylation (GO:0018214)5.71085992
7peptidyl-glutamic acid carboxylation (GO:0017187)5.71085992
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68851007
9aromatic amino acid family catabolic process (GO:0009074)5.64690006
10regulation of fibrinolysis (GO:0051917)5.60501864
11regulation of protein activation cascade (GO:2000257)5.25051205
12bile acid biosynthetic process (GO:0006699)5.14120426
13regulation of apoptotic cell clearance (GO:2000425)5.14097651
14alpha-linolenic acid metabolic process (GO:0036109)5.08242659
15complement activation, alternative pathway (GO:0006957)5.06955988
16kynurenine metabolic process (GO:0070189)5.03088444
17indole-containing compound catabolic process (GO:0042436)5.02178488
18indolalkylamine catabolic process (GO:0046218)5.02178488
19tryptophan catabolic process (GO:0006569)5.02178488
20regulation of complement activation (GO:0030449)4.98767864
21glyoxylate metabolic process (GO:0046487)4.95125897
22high-density lipoprotein particle remodeling (GO:0034375)4.89073426
23sulfur amino acid catabolic process (GO:0000098)4.83878165
24urea cycle (GO:0000050)4.79011227
25urea metabolic process (GO:0019627)4.79011227
26tryptophan metabolic process (GO:0006568)4.72643824
27homocysteine metabolic process (GO:0050667)4.53182269
28low-density lipoprotein particle clearance (GO:0034383)4.49407636
29cysteine metabolic process (GO:0006534)4.44343222
30nitrogen cycle metabolic process (GO:0071941)4.38418247
31fibrinolysis (GO:0042730)4.33481238
32regulation of cholesterol esterification (GO:0010872)4.28777970
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28682003
34bile acid metabolic process (GO:0008206)4.28445751
35reverse cholesterol transport (GO:0043691)4.24836452
36regulation of plasminogen activation (GO:0010755)4.22166467
37regulation of triglyceride catabolic process (GO:0010896)4.21899381
38protein-lipid complex remodeling (GO:0034368)4.17769958
39macromolecular complex remodeling (GO:0034367)4.17769958
40plasma lipoprotein particle remodeling (GO:0034369)4.17769958
41serine family amino acid catabolic process (GO:0009071)4.17253717
42plasma lipoprotein particle clearance (GO:0034381)4.15905876
43ethanol metabolic process (GO:0006067)4.11671274
44tyrosine metabolic process (GO:0006570)4.08565171
45aromatic amino acid family metabolic process (GO:0009072)4.06648226
46acylglycerol homeostasis (GO:0055090)4.05258679
47triglyceride homeostasis (GO:0070328)4.05258679
48positive regulation of fatty acid beta-oxidation (GO:0032000)4.04420551
49cellular glucuronidation (GO:0052695)4.04021012
50epoxygenase P450 pathway (GO:0019373)4.00643551
51amino-acid betaine metabolic process (GO:0006577)3.96460313
52phospholipid efflux (GO:0033700)3.96028151
53opsonization (GO:0008228)3.95191035
54negative regulation of cholesterol transport (GO:0032375)3.92734414
55negative regulation of sterol transport (GO:0032372)3.92734414
56coenzyme catabolic process (GO:0009109)3.89736336
57intestinal cholesterol absorption (GO:0030299)3.88419311
58lysine catabolic process (GO:0006554)3.87647568
59lysine metabolic process (GO:0006553)3.87647568
60neutral lipid catabolic process (GO:0046461)3.85117297
61acylglycerol catabolic process (GO:0046464)3.85117297
62alpha-amino acid catabolic process (GO:1901606)3.82444958
63glycine metabolic process (GO:0006544)3.79292491
64triglyceride catabolic process (GO:0019433)3.78602522
65plasma lipoprotein particle organization (GO:0071827)3.76774493
66protein-lipid complex subunit organization (GO:0071825)3.71293885
67bile acid and bile salt transport (GO:0015721)3.71152432
68positive regulation of lipid catabolic process (GO:0050996)3.69755478
69cellular modified amino acid catabolic process (GO:0042219)3.68086833
70negative regulation of complement activation (GO:0045916)3.68044073
71negative regulation of hemostasis (GO:1900047)3.66333403
72negative regulation of blood coagulation (GO:0030195)3.66333403
73cellular ketone body metabolic process (GO:0046950)3.66083920
74negative regulation of protein activation cascade (GO:2000258)3.65899364
75positive regulation of extracellular matrix organization (GO:1903055)3.62424280
76cholesterol efflux (GO:0033344)3.61547813
77serine family amino acid biosynthetic process (GO:0009070)3.61474308
78glucuronate metabolic process (GO:0019585)3.57996128
79uronic acid metabolic process (GO:0006063)3.57996128
80regulation of lipoprotein metabolic process (GO:0050746)3.56299776
81cellular amino acid catabolic process (GO:0009063)3.55620732
82arginine metabolic process (GO:0006525)3.54869662
83diacylglycerol metabolic process (GO:0046339)3.54583582
84serine family amino acid metabolic process (GO:0009069)3.53317090
85positive regulation of fatty acid oxidation (GO:0046321)3.50289779
86imidazole-containing compound metabolic process (GO:0052803)3.49850746
87plasma lipoprotein particle assembly (GO:0034377)3.49515447
88aldehyde catabolic process (GO:0046185)3.48737441
89benzene-containing compound metabolic process (GO:0042537)3.48648617
90positive regulation of hemostasis (GO:1900048)3.45892095
91positive regulation of blood coagulation (GO:0030194)3.45892095
92blood coagulation, intrinsic pathway (GO:0007597)3.45614483
93regulation of fatty acid beta-oxidation (GO:0031998)3.45303551
94ethanol oxidation (GO:0006069)3.44965421
95glutamate metabolic process (GO:0006536)3.44179549
96indolalkylamine metabolic process (GO:0006586)3.44138518
97amine catabolic process (GO:0009310)3.41697302
98cellular biogenic amine catabolic process (GO:0042402)3.41697302
99complement activation (GO:0006956)3.41015076
100negative regulation of coagulation (GO:0050819)3.39265998
101cofactor catabolic process (GO:0051187)3.39042324
102complement activation, classical pathway (GO:0006958)3.38980162
103regulation of cholesterol homeostasis (GO:2000188)3.36862029
104protein activation cascade (GO:0072376)3.36474139
105negative regulation of lipase activity (GO:0060192)3.34957173
106lipoprotein metabolic process (GO:0042157)3.33972472
107low-density lipoprotein particle remodeling (GO:0034374)3.32284441
108protein-lipid complex assembly (GO:0065005)3.32015021
109positive regulation of lipoprotein lipase activity (GO:0051006)3.30460205
110positive regulation of triglyceride lipase activity (GO:0061365)3.30460205
111regulation of humoral immune response (GO:0002920)3.30359715
112dicarboxylic acid biosynthetic process (GO:0043650)3.28554454
113cholesterol homeostasis (GO:0042632)3.27232341
114protein heterotrimerization (GO:0070208)3.26092029
115negative regulation of wound healing (GO:0061045)3.23563461
116cytolysis (GO:0019835)3.23538282
117fatty acid homeostasis (GO:0055089)3.22974271
118sterol homeostasis (GO:0055092)3.22417835
119acute-phase response (GO:0006953)3.22363804
120collagen fibril organization (GO:0030199)3.20196412
121very-low-density lipoprotein particle assembly (GO:0034379)3.18575774
122positive regulation of coagulation (GO:0050820)3.18209133
123primary alcohol metabolic process (GO:0034308)3.13177354
124glomerular basement membrane development (GO:0032836)3.09384975
125negative regulation of lipid transport (GO:0032369)3.05784127
126exogenous drug catabolic process (GO:0042738)3.05063607
127positive regulation of fatty acid biosynthetic process (GO:0045723)3.01908072
128drug catabolic process (GO:0042737)2.99967841
129basement membrane organization (GO:0071711)2.99559378
130intestinal absorption (GO:0050892)2.93479344
131negative regulation of humoral immune response (GO:0002921)2.93093914
132regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.88956195
133retinal metabolic process (GO:0042574)2.88931684
134regulation of bile acid biosynthetic process (GO:0070857)2.87928280
135positive regulation of lipid storage (GO:0010884)2.86222810
136response to mercury ion (GO:0046689)2.85480212
137primary alcohol catabolic process (GO:0034310)2.83820006
138glycerolipid catabolic process (GO:0046503)2.83671946
139regulation of sequestering of triglyceride (GO:0010889)2.83558919
140positive regulation of steroid metabolic process (GO:0045940)2.79675717
141regulation of cholesterol biosynthetic process (GO:0045540)2.76637244
142positive regulation of wound healing (GO:0090303)2.72832098
143sterol transport (GO:0015918)2.72767470
144cholesterol transport (GO:0030301)2.72767470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.34872207
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.21085657
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.65856564
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.55030340
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18640139
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09945671
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.99352854
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.65204221
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.56423744
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.36091766
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.06843275
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.94741738
13CLOCK_20551151_ChIP-Seq_293T_Human2.93064089
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57996605
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09371221
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08314482
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4014964
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80245748
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76308630
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70278827
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61839107
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59785888
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57789674
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56009813
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55969210
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46509804
27* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45251159
28* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45251159
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43782598
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42187401
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37251466
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36591803
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30458622
34CJUN_26792858_Chip-Seq_BT549_Human1.23961121
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23564704
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.17684505
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.17322329
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15625757
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12568320
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11409962
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11284035
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08116803
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07717441
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.05767885
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.05490635
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02935372
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02935372
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00870081
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98969320
50SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97947029
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97820433
52RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96789984
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96518372
54LXR_22292898_ChIP-Seq_THP-1_Human0.95302901
55PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95257909
56* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95190183
57CTCF_27219007_Chip-Seq_Bcells_Human0.94683627
58ELK3_25401928_ChIP-Seq_HUVEC_Human0.92785543
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91831053
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91817564
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90569563
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90425485
63WT1_19549856_ChIP-ChIP_CCG9911_Human0.90125086
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90014223
65MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89538384
66TCF4_18268006_ChIP-ChIP_LS174T_Human0.89166390
67PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89140727
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89125673
69HTT_18923047_ChIP-ChIP_STHdh_Human0.88160164
70ZNF263_19887448_ChIP-Seq_K562_Human0.87390224
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86281503
72BRD4_25478319_ChIP-Seq_HGPS_Human0.85582931
73HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84779629
74* SOX2_20726797_ChIP-Seq_SW620_Human0.83408621
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82796511
76SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81906810
77EED_16625203_ChIP-ChIP_MESCs_Mouse0.81410711
78GATA1_22025678_ChIP-Seq_K562_Human0.78975514
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78371542
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.77485248
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77138136
82KDM2B_26808549_Chip-Seq_K562_Human0.76869227
83SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76563098
84ATF3_27146783_Chip-Seq_COLON_Human0.75597257
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74573615
86* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74504368
87MYC_27129775_Chip-Seq_CORNEA_Mouse0.74459012
88DROSHA_22980978_ChIP-Seq_HELA_Human0.74394905
89RACK7_27058665_Chip-Seq_MCF-7_Human0.74213114
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73613909
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73347869
92SMC4_20622854_ChIP-Seq_HELA_Human0.73215129
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72348908
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72267929
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71835615
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71184406
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71018394
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69876463
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67866356
100CSB_26484114_Chip-Seq_FIBROBLAST_Human0.67857772
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.67444846
102GATA4_25053715_ChIP-Seq_YYC3_Human0.66908565
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66562125
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.66526342
105TBX20_22328084_ChIP-Seq_HEART_Mouse0.66526342
106EGR1_19032775_ChIP-ChIP_M12_Human0.64278173
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64026831
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.62997250
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62913621
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.62563014
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62427703
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.62275354
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.60515507
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.60318300
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.59897353
116SA1_22415368_ChIP-Seq_MEFs_Mouse0.59613206
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59019154
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58592345
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57972722
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.56786004
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.56383225
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55911369
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55670064
124TP53_18474530_ChIP-ChIP_U2OS_Human0.55318648
125* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55022618
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.54963258
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.53852379
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.52788028
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.52788028
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51318268
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.51310697
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.50730570
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.49964687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.31918649
2MP0008438_abnormal_cutaneous_collagen5.82456874
3MP0005360_urolithiasis5.64154592
4MP0005085_abnormal_gallbladder_physiolo4.58113798
5MP0005365_abnormal_bile_salt4.51360172
6MP0005503_abnormal_tendon_morphology3.96221796
7MP0005275_abnormal_skin_tensile3.60186286
8MP0008875_abnormal_xenobiotic_pharmacok3.55066078
9MP0003705_abnormal_hypodermis_morpholog3.53945158
10MP0003252_abnormal_bile_duct3.33221502
11MP0003806_abnormal_nucleotide_metabolis3.19264651
12MP0010329_abnormal_lipoprotein_level2.69005853
13MP0009840_abnormal_foam_cell2.53789685
14MP0003279_aneurysm2.43272648
15MP0003195_calcinosis2.26537194
16MP0000751_myopathy2.22214150
17MP0005083_abnormal_biliary_tract2.18759254
18MP0005332_abnormal_amino_acid1.99619154
19MP0009384_cardiac_valve_regurgitation1.95211556
20MP0005058_abnormal_lysosome_morphology1.87229048
21MP0001958_emphysema1.85642709
22MP0001666_abnormal_nutrient_absorption1.70447804
23MP0010368_abnormal_lymphatic_system1.69896592
24MP0002060_abnormal_skin_morphology1.61943573
25MP0000609_abnormal_liver_physiology1.61422273
26MP0003191_abnormal_cellular_cholesterol1.59541706
27MP0005257_abnormal_intraocular_pressure1.59440647
28MP0003878_abnormal_ear_physiology1.57762276
29MP0005377_hearing/vestibular/ear_phenot1.57762276
30MP0002876_abnormal_thyroid_physiology1.56177590
31MP0003122_maternal_imprinting1.50691279
32MP0002118_abnormal_lipid_homeostasis1.50503510
33MP0001542_abnormal_bone_strength1.50420141
34MP0005375_adipose_tissue_phenotype1.42775361
35MP0005319_abnormal_enzyme/_coenzyme1.37548578
36MP0006138_congestive_heart_failure1.36065785
37MP0005023_abnormal_wound_healing1.35695323
38MP0004019_abnormal_vitamin_homeostasis1.33618692
39MP0002295_abnormal_pulmonary_circulatio1.33306590
40MP0003868_abnormal_feces_composition1.31633951
41MP0001243_abnormal_dermal_layer1.30523711
42MP0005171_absent_coat_pigmentation1.27271875
43MP0004272_abnormal_basement_membrane1.26705220
44MP0005508_abnormal_skeleton_morphology1.26685478
45MP0006054_spinal_hemorrhage1.26414832
46MP0003950_abnormal_plasma_membrane1.24113775
47MP0003011_delayed_dark_adaptation1.23174582
48MP0009053_abnormal_anal_canal1.20989566
49MP0002108_abnormal_muscle_morphology1.18093002
50MP0000003_abnormal_adipose_tissue1.15400060
51MP0009697_abnormal_copulation1.13888732
52MP0003646_muscle_fatigue1.10090755
53MP0009780_abnormal_chondrocyte_physiolo1.09187281
54MP0005584_abnormal_enzyme/coenzyme_acti1.06174218
55MP0002132_abnormal_respiratory_system1.03937466
56MP0002138_abnormal_hepatobiliary_system1.03329766
57MP0000598_abnormal_liver_morphology1.00311494
58MP0003828_pulmonary_edema1.00043606
59MP0002089_abnormal_postnatal_growth/wei0.99784794
60MP0004087_abnormal_muscle_fiber0.98950025
61MP0000749_muscle_degeneration0.96598999
62MP0003186_abnormal_redox_activity0.94520509
63MP0003724_increased_susceptibility_to0.92453902
64MP0005369_muscle_phenotype0.92190711
65MP0002933_joint_inflammation0.91434035
66MP0003566_abnormal_cell_adhesion0.90799063
67MP0002896_abnormal_bone_mineralization0.89689501
68MP0001324_abnormal_eye_pigmentation0.89070538
69MP0000013_abnormal_adipose_tissue0.88869077
70MP0003656_abnormal_erythrocyte_physiolo0.86850287
71MP0005330_cardiomyopathy0.85505058
72MP0003879_abnormal_hair_cell0.85298888
73MP0000759_abnormal_skeletal_muscle0.84200171
74MP0001764_abnormal_homeostasis0.84164818
75MP0003690_abnormal_glial_cell0.84072317
76MP0005409_darkened_coat_color0.82759329
77MP0002106_abnormal_muscle_physiology0.82502721
78MP0005167_abnormal_blood-brain_barrier0.82279824
79MP0004036_abnormal_muscle_relaxation0.82154510
80MP0005390_skeleton_phenotype0.81803457
81MP0009764_decreased_sensitivity_to0.81698633
82MP0009763_increased_sensitivity_to0.80052873
83MP0002970_abnormal_white_adipose0.79975564
84MP0009643_abnormal_urine_homeostasis0.79502804
85MP0002168_other_aberrant_phenotype0.78097713
86MP0005595_abnormal_vascular_smooth0.75936104
87MP0003329_amyloid_beta_deposits0.75739308
88MP0000767_abnormal_smooth_muscle0.73911348
89MP0010030_abnormal_orbit_morphology0.72969676
90MP0001533_abnormal_skeleton_physiology0.72794525
91MP0005084_abnormal_gallbladder_morpholo0.72316375
92MP0003123_paternal_imprinting0.71765296
93MP0002269_muscular_atrophy0.71450199
94MP0000566_synostosis0.71076272
95MP0003959_abnormal_lean_body0.70736874
96MP0000747_muscle_weakness0.70099234
97MP0009250_abnormal_appendicular_skeleto0.69891840
98MP0005647_abnormal_sex_gland0.69843136
99MP0005448_abnormal_energy_balance0.69268654
100MP0002282_abnormal_trachea_morphology0.68607032
101MP0000372_irregular_coat_pigmentation0.67420497
102MP0002971_abnormal_brown_adipose0.66956835
103MP0005670_abnormal_white_adipose0.66620167
104MP0002115_abnormal_skeleton_extremities0.65810832
105MP0003942_abnormal_urinary_system0.65567911
106MP0000604_amyloidosis0.65007374
107MP0010630_abnormal_cardiac_muscle0.64941994
108MP0000163_abnormal_cartilage_morphology0.64844599
109MP0004084_abnormal_cardiac_muscle0.64358952
110MP0005164_abnormal_response_to0.63420085
111MP0004883_abnormal_blood_vessel0.61183009
112MP0002254_reproductive_system_inflammat0.60046960
113MP0001661_extended_life_span0.58466742
114MP0005451_abnormal_body_composition0.58458695
115MP0002128_abnormal_blood_circulation0.58371515
116MP0003091_abnormal_cell_migration0.58098543
117MP0009379_abnormal_foot_pigmentation0.57586087
118MP0009642_abnormal_blood_homeostasis0.57395854
119MP0004130_abnormal_muscle_cell0.57217882
120MP0002837_dystrophic_cardiac_calcinosis0.57024218
121MP0008469_abnormal_protein_level0.56096986
122MP0005666_abnormal_adipose_tissue0.55973334
123MP0000249_abnormal_blood_vessel0.55087036
124* MP0005220_abnormal_exocrine_pancreas0.54924023
125MP0002249_abnormal_larynx_morphology0.53920329
126MP0005395_other_phenotype0.53355016
127MP0005408_hypopigmentation0.53161421
128MP0002998_abnormal_bone_remodeling0.52900086
129MP0005376_homeostasis/metabolism_phenot0.52752384
130MP0009115_abnormal_fat_cell0.52471891
131MP0005334_abnormal_fat_pad0.52044932
132MP0001915_intracranial_hemorrhage0.51239416
133MP0003385_abnormal_body_wall0.48485448
134MP0004185_abnormal_adipocyte_glucose0.47713250
135MP0002932_abnormal_joint_morphology0.47561955
136MP0005197_abnormal_uvea_morphology0.47539096
137MP0000639_abnormal_adrenal_gland0.46954949
138MP0005636_abnormal_mineral_homeostasis0.46847829
139MP0003300_gastrointestinal_ulcer0.46058699
140MP0003115_abnormal_respiratory_system0.45499511
141MP0005248_abnormal_Harderian_gland0.44829188

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.44476999
2* Protrusio acetabuli (HP:0003179)6.27163006
3Premature rupture of membranes (HP:0001788)5.94270329
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.45842273
5Intrahepatic cholestasis (HP:0001406)5.36546160
6Xanthomatosis (HP:0000991)5.35477364
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.06006894
8Prolonged partial thromboplastin time (HP:0003645)5.00742554
9Hypobetalipoproteinemia (HP:0003563)4.74864382
10Complement deficiency (HP:0004431)4.48041994
11Peritonitis (HP:0002586)4.33830489
12Hyperlipoproteinemia (HP:0010980)4.28598202
13Hypolipoproteinemia (HP:0010981)3.94859211
14Abnormality of the common coagulation pathway (HP:0010990)3.87066396
15Hypoalphalipoproteinemia (HP:0003233)3.82000676
16Abnormality of complement system (HP:0005339)3.62327517
17Hemorrhage of the eye (HP:0011885)3.61276142
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55448000
19Joint hemorrhage (HP:0005261)3.53878123
20Abnormality of the intrinsic pathway (HP:0010989)3.41790769
21Nephritis (HP:0000123)3.38235950
22Soft skin (HP:0000977)3.33733614
23Hyperammonemia (HP:0001987)3.30104548
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29730705
25Aortic dissection (HP:0002647)3.27302864
26Epidermoid cyst (HP:0200040)3.23891248
27Myocardial infarction (HP:0001658)3.19870244
28Broad metatarsal (HP:0001783)3.10965175
29Mitral stenosis (HP:0001718)3.07628876
30Abnormal delivery (HP:0001787)3.03891125
31Ankle contracture (HP:0006466)3.01339932
32Hyperglycinemia (HP:0002154)3.00810365
33Abnormality of sulfur amino acid metabolism (HP:0004339)2.98805033
34Abnormality of methionine metabolism (HP:0010901)2.98542794
35Ketosis (HP:0001946)2.97407969
36Fat malabsorption (HP:0002630)2.95616407
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87060084
38* Biconcave vertebral bodies (HP:0004586)2.85162198
39Skin nodule (HP:0200036)2.84444280
40Aortic aneurysm (HP:0004942)2.84078602
41Hypoglycemic coma (HP:0001325)2.74658994
42Blue sclerae (HP:0000592)2.72989457
43Hypercholesterolemia (HP:0003124)2.70539699
44Cardiovascular calcification (HP:0011915)2.69712004
45Abnormality of serine family amino acid metabolism (HP:0010894)2.69019636
46Abnormality of glycine metabolism (HP:0010895)2.69019636
47Nonimmune hydrops fetalis (HP:0001790)2.61946448
48Vascular tortuosity (HP:0004948)2.58836365
49Shallow orbits (HP:0000586)2.58778937
50Abnormality of carpal bone ossification (HP:0006257)2.58778843
51Ectopia lentis (HP:0001083)2.58715038
52Mitral valve prolapse (HP:0001634)2.56242490
53Dilatation of the ascending aorta (HP:0005111)2.53986449
54Bladder diverticulum (HP:0000015)2.53079066
55Hepatocellular carcinoma (HP:0001402)2.52940998
56Abnormality of pyrimidine metabolism (HP:0004353)2.51851121
57Hyperglycinuria (HP:0003108)2.49399559
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49233109
59Spontaneous abortion (HP:0005268)2.48376076
60Fragile skin (HP:0001030)2.46831685
61Atrophic scars (HP:0001075)2.44981805
62Abnormality of fatty-acid metabolism (HP:0004359)2.41146940
63Abnormality of dentin (HP:0010299)2.39983101
64Purpura (HP:0000979)2.39463957
65Abnormality of the Achilles tendon (HP:0005109)2.39299454
66Neonatal short-limb short stature (HP:0008921)2.37900473
67Wormian bones (HP:0002645)2.36464937
68Exercise-induced myalgia (HP:0003738)2.36043357
69Infantile muscular hypotonia (HP:0008947)2.35783201
70Increased variability in muscle fiber diameter (HP:0003557)2.34265727
71Cervical subluxation (HP:0003308)2.30634543
72Delayed CNS myelination (HP:0002188)2.30437582
73Hyperbilirubinemia (HP:0002904)2.28225468
74Cerebral aneurysm (HP:0004944)2.26688561
75Arterial tortuosity (HP:0005116)2.26281157
76Conjugated hyperbilirubinemia (HP:0002908)2.26206367
77Ulnar deviation of the wrist (HP:0003049)2.26003756
78Mesangial abnormality (HP:0001966)2.24395635
79Systemic lupus erythematosus (HP:0002725)2.23890553
80Genu recurvatum (HP:0002816)2.22363483
81Abnormal cartilage morphology (HP:0002763)2.21856136
82Type 1 muscle fiber predominance (HP:0003803)2.18327921
83Steatorrhea (HP:0002570)2.16692820
84Vascular calcification (HP:0004934)2.16471966
85Amyloidosis (HP:0011034)2.16296372
86Increased connective tissue (HP:0009025)2.15837933
87* Vertebral compression fractures (HP:0002953)2.14738341
88Follicular hyperkeratosis (HP:0007502)2.14007414
89Ovoid vertebral bodies (HP:0003300)2.12725061
90Arthropathy (HP:0003040)2.11951695
91Small epiphyses (HP:0010585)2.11553289
92Asymmetric septal hypertrophy (HP:0001670)2.10433310
93Abnormality of serum amino acid levels (HP:0003112)2.09919725
94Osteomalacia (HP:0002749)2.09403445
95Gonadal dysgenesis (HP:0000133)2.08630113
96Abnormality of nucleobase metabolism (HP:0010932)2.02895424
97Rickets (HP:0002748)2.02298885
98Round ear (HP:0100830)2.01466271
99Back pain (HP:0003418)2.01335738
100Hypertriglyceridemia (HP:0002155)2.01150881
101Flared iliac wings (HP:0002869)1.99763821
102Spinal rigidity (HP:0003306)1.99332035
103Abnormality of skeletal muscle fiber size (HP:0012084)1.98527869
104Mucopolysacchariduria (HP:0008155)1.96380980
105Urinary glycosaminoglycan excretion (HP:0003541)1.96380980
106Wide anterior fontanel (HP:0000260)1.94704171
107Ketoacidosis (HP:0001993)1.94392048
108Testicular neoplasm (HP:0010788)1.93544297
109Hyperextensible skin (HP:0000974)1.92423559
110Glomerulonephritis (HP:0000099)1.92067144
111Hypophosphatemic rickets (HP:0004912)1.90433609
112Slender build (HP:0001533)1.87804449
113Cupped ribs (HP:0000887)1.87774025
114Facial shape deformation (HP:0011334)1.87538980
115Potter facies (HP:0002009)1.87538980
116Aneurysm (HP:0002617)1.87240839
117Gingival bleeding (HP:0000225)1.86588969
118Abnormal hand bone ossification (HP:0010660)1.86315325
119Achilles tendon contracture (HP:0001771)1.85904062
120Overgrowth (HP:0001548)1.85630491
121Abnormal ossification of hand bones (HP:0005921)1.85276145
122Spastic diplegia (HP:0001264)1.84880810
123Opisthotonus (HP:0002179)1.84793582
124Oligomenorrhea (HP:0000876)1.84111439
125Abnormal gallbladder physiology (HP:0012438)1.82347886
126Cholecystitis (HP:0001082)1.82347886
127Striae distensae (HP:0001065)1.81799947
128Hydroxyprolinuria (HP:0003080)1.81621653
129Abnormality of proline metabolism (HP:0010907)1.81621653
130Menorrhagia (HP:0000132)1.81617172
131Neonatal onset (HP:0003623)1.81143719
132Abnormality of polysaccharide metabolism (HP:0011012)1.80367322
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80367322
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80367322
135Abnormal gallbladder morphology (HP:0012437)1.78825236
136Abnormality of purine metabolism (HP:0004352)1.78417576
137Polycythemia (HP:0001901)1.77908655
138Abnormality of the peritoneum (HP:0002585)1.76892414
139Joint stiffness (HP:0001387)1.76810519
140Recurrent gram-negative bacterial infections (HP:0005420)1.76520703
141Flat acetabular roof (HP:0003180)1.70985626
142Nemaline bodies (HP:0003798)1.69800651
143Epiphyseal dysplasia (HP:0002656)1.69672329
144Muscle fiber splitting (HP:0003555)1.69251272
145Acanthosis nigricans (HP:0000956)1.67249988
146Muscle fiber inclusion bodies (HP:0100299)1.66954397
147Pigmentary retinal degeneration (HP:0001146)1.65787398
148* Abnormality of the acetabulum (HP:0003170)1.65059405
149Mildly elevated creatine phosphokinase (HP:0008180)1.64288551
150Abnormal tarsal ossification (HP:0008369)1.64213490
151Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63030975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.95955940
2BCKDK4.38177934
3SIK14.20622798
4TRIB34.13675814
5PKN23.22563622
6FGFR43.13472897
7DDR23.12235112
8LATS22.64214714
9LATS12.42137496
10PDGFRA2.37517362
11ICK2.18916490
12NEK92.13961757
13EPHA32.13814892
14OBSCN2.08931609
15FLT32.02216983
16PIK3CG1.96197380
17TTN1.78864134
18ERBB41.70182448
19MAPKAPK31.69585012
20PTK61.46358757
21MUSK1.46024191
22FER1.44109630
23TGFBR21.43796225
24TYRO31.41893139
25CDC42BPA1.39792622
26ABL21.39171981
27MST1R1.29279908
28WNK41.28391764
29EPHB21.25120418
30PAK21.24396871
31PIM21.22255156
32PDPK11.21929192
33MAP3K61.20584896
34MAP2K31.20007407
35RIPK11.18366923
36NME21.17503912
37PTK21.17092490
38FRK1.16102754
39PHKG21.14757517
40PHKG11.14757517
41STK38L1.13622521
42INSRR1.13504433
43MAPK111.11938721
44MET1.07859485
45TAOK31.06245517
46BMX1.03059099
47EPHB10.98811684
48MOS0.98318176
49JAK10.95736907
50SGK2230.95247092
51SGK4940.95247092
52TBK10.94857363
53KDR0.94590604
54PIK3CA0.92933787
55WNK10.91815456
56AKT30.90991831
57RPS6KA40.90462524
58PTK2B0.89233118
59NLK0.88578478
60MAP2K40.88555984
61CDK60.87181461
62TYK20.87000559
63MARK20.86804609
64PRKAA10.85683885
65MAP3K30.84288097
66FGFR20.82026043
67MYLK0.79459062
68MAP2K10.79031690
69MAP3K100.78708319
70DYRK1B0.78248067
71MAPK150.75437858
72PAK30.75263729
73CAMK1D0.74657473
74KIT0.73995989
75STK30.73952460
76LRRK20.73126080
77SGK20.72064163
78MAPK70.71733757
79ERBB20.71490079
80TRPM70.70840196
81SGK30.70682660
82MAP3K70.70208581
83MTOR0.69673586
84PRKAA20.68688712
85MAP3K110.68305311
86TESK20.67282381
87TAOK20.64561881
88FGFR10.64457942
89MAPK40.63878521
90RET0.62150110
91PDK10.61763529
92DAPK30.61028343
93CSK0.60834315
94PRKG10.60472328
95JAK20.56033654
96PINK10.55198500
97FGFR30.54372666
98GRK10.53999921
99CDK120.53610167
100PAK40.52989491
101SGK10.51816596
102MAP3K20.51577233
103ROCK10.50300719
104MAP3K10.50217980
105STK380.48055878
106PDK20.46842993
107CDK40.46782498
108CAMK10.46390305
109TGFBR10.45692580
110PDGFRB0.45612370
111MAPK120.40813547
112RPS6KA30.40553310
113PRKD10.39907637
114EIF2AK10.39652801
115IGF1R0.39623833
116MAPK30.39196152
117TESK10.39009411
118* PRKACA0.37151530
119KSR20.37022057
120CSF1R0.36617345
121RPS6KA20.36351586
122TAOK10.36248816
123GSK3A0.36088705
124PRKD20.35861940
125ILK0.35808311
126NTRK10.35081414
127AKT20.34849552
128NTRK30.34358398
129INSR0.33042303
130JAK30.32316636
131EEF2K0.30530882
132CAMK2G0.30463029
133PRKACG0.29628172
134TIE10.29439425
135PRKCZ0.29089747
136MAP3K50.27903313
137PRKG20.27659040
138ADRBK10.27545556
139IRAK10.26388562
140ABL10.25528917
141LIMK10.24560828
142SRC0.21662189

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45721456
2Nitrogen metabolism_Homo sapiens_hsa009103.47293689
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38404920
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12610210
5Complement and coagulation cascades_Homo sapiens_hsa046103.00731496
6Arginine biosynthesis_Homo sapiens_hsa002202.89289167
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58762167
8Tryptophan metabolism_Homo sapiens_hsa003802.58228988
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51924928
10Fatty acid degradation_Homo sapiens_hsa000712.46608517
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43451506
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28529424
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26077035
14Caffeine metabolism_Homo sapiens_hsa002322.02437806
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02354652
16Chemical carcinogenesis_Homo sapiens_hsa052042.02344779
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95769672
18PPAR signaling pathway_Homo sapiens_hsa033201.95318804
19Peroxisome_Homo sapiens_hsa041461.90821977
20Butanoate metabolism_Homo sapiens_hsa006501.88111843
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.84045827
22Fatty acid metabolism_Homo sapiens_hsa012121.76584070
23Propanoate metabolism_Homo sapiens_hsa006401.72990956
24Staphylococcus aureus infection_Homo sapiens_hsa051501.72009844
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.68209873
26Histidine metabolism_Homo sapiens_hsa003401.66306628
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65086636
28Retinol metabolism_Homo sapiens_hsa008301.64245678
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56140390
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52911062
31beta-Alanine metabolism_Homo sapiens_hsa004101.51688920
32Selenocompound metabolism_Homo sapiens_hsa004501.47874676
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45209013
34Phenylalanine metabolism_Homo sapiens_hsa003601.43129340
35Starch and sucrose metabolism_Homo sapiens_hsa005001.40585281
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39985021
37Bile secretion_Homo sapiens_hsa049761.36585466
38Tyrosine metabolism_Homo sapiens_hsa003501.34597908
39Pyruvate metabolism_Homo sapiens_hsa006201.28229092
40Other glycan degradation_Homo sapiens_hsa005111.24600345
41Sulfur metabolism_Homo sapiens_hsa009201.21015650
42Folate biosynthesis_Homo sapiens_hsa007901.20827322
43Biosynthesis of amino acids_Homo sapiens_hsa012301.16564097
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.16069929
45Fatty acid elongation_Homo sapiens_hsa000621.12941969
46Steroid biosynthesis_Homo sapiens_hsa001001.12413158
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.10929951
48Sulfur relay system_Homo sapiens_hsa041221.08675606
49Fat digestion and absorption_Homo sapiens_hsa049751.07638567
50Carbon metabolism_Homo sapiens_hsa012001.07019780
51Arginine and proline metabolism_Homo sapiens_hsa003301.04017984
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98230673
53One carbon pool by folate_Homo sapiens_hsa006700.93508159
54ABC transporters_Homo sapiens_hsa020100.91179655
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87194354
56Vitamin B6 metabolism_Homo sapiens_hsa007500.83768904
57Lysine degradation_Homo sapiens_hsa003100.83426838
58ECM-receptor interaction_Homo sapiens_hsa045120.77352835
59Vitamin digestion and absorption_Homo sapiens_hsa049770.77328784
60Glutathione metabolism_Homo sapiens_hsa004800.76166577
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75334007
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75183209
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67536954
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64760756
65Pertussis_Homo sapiens_hsa051330.58093997
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57024015
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.54137630
68Dilated cardiomyopathy_Homo sapiens_hsa054140.52129569
69Glycerolipid metabolism_Homo sapiens_hsa005610.49837690
70Pentose phosphate pathway_Homo sapiens_hsa000300.49237850
71Prion diseases_Homo sapiens_hsa050200.48503904
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45871081
73Malaria_Homo sapiens_hsa051440.44188412
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43786752
75Galactose metabolism_Homo sapiens_hsa000520.41724088
76Protein digestion and absorption_Homo sapiens_hsa049740.41592066
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39476482
78Fatty acid biosynthesis_Homo sapiens_hsa000610.39012365
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.35294441
80Metabolic pathways_Homo sapiens_hsa011000.35036024
81Bladder cancer_Homo sapiens_hsa052190.35035730
82Insulin resistance_Homo sapiens_hsa049310.34660641
83Circadian rhythm_Homo sapiens_hsa047100.32739257
84Amoebiasis_Homo sapiens_hsa051460.29363607
85Focal adhesion_Homo sapiens_hsa045100.28356269
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.26879822
87Lysosome_Homo sapiens_hsa041420.25935257
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25338537
89Mineral absorption_Homo sapiens_hsa049780.22822392
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19931383
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19829686
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17644257
93Sphingolipid metabolism_Homo sapiens_hsa006000.15249934
94AMPK signaling pathway_Homo sapiens_hsa041520.14876211
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.12637064
96Fructose and mannose metabolism_Homo sapiens_hsa000510.11936228
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.11218481
98Glucagon signaling pathway_Homo sapiens_hsa049220.10304717
99Proteoglycans in cancer_Homo sapiens_hsa052050.09618817
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08783612
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.08738282
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07816024
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04831629
104TGF-beta signaling pathway_Homo sapiens_hsa043500.03543326
105Linoleic acid metabolism_Homo sapiens_hsa005910.03041513
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.02269859
107Insulin signaling pathway_Homo sapiens_hsa049100.00641040
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1058961
109Renin-angiotensin system_Homo sapiens_hsa04614-0.0910198
110Melanoma_Homo sapiens_hsa05218-0.0745918
111Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0437112
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0009574

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