SERPINB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)8.48118521
2phosphatidylinositol acyl-chain remodeling (GO:0036149)8.46519206
3peptide cross-linking (GO:0018149)8.38598560
4phosphatidylserine acyl-chain remodeling (GO:0036150)8.35095333
5hair cycle (GO:0042633)8.14561609
6molting cycle (GO:0042303)8.14561609
7detection of bacterium (GO:0016045)7.93774934
8long-chain fatty acid biosynthetic process (GO:0042759)7.87630689
9epidermis development (GO:0008544)7.74309619
10sequestering of metal ion (GO:0051238)7.44389554
11detection of other organism (GO:0098543)7.24355728
12keratinocyte proliferation (GO:0043616)7.05832707
13water homeostasis (GO:0030104)7.03775737
14gap junction assembly (GO:0016264)6.87369925
15lipoxygenase pathway (GO:0019372)6.71973884
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.70281280
17positive regulation of monocyte chemotaxis (GO:0090026)6.69454424
18phosphatidylethanolamine acyl-chain remodeling (GO:0036152)6.64299106
19regulation of T cell chemotaxis (GO:0010819)6.50158157
20positive regulation of T cell chemotaxis (GO:0010820)6.50158157
21bundle of His cell to Purkinje myocyte communication (GO:0086069)6.29652029
22regulation of natural killer cell differentiation (GO:0032823)6.05840366
23linoleic acid metabolic process (GO:0043651)5.88557201
24phosphatidylcholine acyl-chain remodeling (GO:0036151)5.87461117
25negative regulation of interferon-gamma production (GO:0032689)5.62129930
26negative regulation of interleukin-17 production (GO:0032700)5.19470487
27phosphatidylserine metabolic process (GO:0006658)5.12307954
28skin morphogenesis (GO:0043589)5.10351021
29regulation of transforming growth factor beta1 production (GO:0032908)5.04510753
30regulation of monocyte chemotaxis (GO:0090025)4.87954081
31intermediate filament organization (GO:0045109)4.74079028
32intermediate filament cytoskeleton organization (GO:0045104)4.66861123
33hemidesmosome assembly (GO:0031581)4.52239734
34intermediate filament-based process (GO:0045103)4.52238096
35establishment of tissue polarity (GO:0007164)4.40638361
36establishment of planar polarity (GO:0001736)4.40638361
37detection of external biotic stimulus (GO:0098581)4.12686409
38alditol phosphate metabolic process (GO:0052646)4.12167059
39phospholipid catabolic process (GO:0009395)4.10094611
40ectoderm development (GO:0007398)4.09423619
41surfactant homeostasis (GO:0043129)4.04074268
42regulation of lymphocyte chemotaxis (GO:1901623)3.92977843
43ceramide biosynthetic process (GO:0046513)3.86584360
44positive regulation of glomerulus development (GO:0090193)3.79576377
45positive regulation of granulocyte chemotaxis (GO:0071624)3.67393915
46positive regulation of p38MAPK cascade (GO:1900745)3.60440221
47epithelium development (GO:0060429)3.56068424
48chemical homeostasis within a tissue (GO:0048875)3.50521365
49detection of biotic stimulus (GO:0009595)3.47361500
50phosphatidylglycerol metabolic process (GO:0046471)3.46456690
51keratinocyte development (GO:0003334)3.46349587
52interleukin-6-mediated signaling pathway (GO:0070102)3.44186012
53defense response to Gram-negative bacterium (GO:0050829)3.39380891
54peptidyl-proline hydroxylation (GO:0019511)3.27603372
55regulation of cell proliferation involved in kidney development (GO:1901722)3.17557263
56positive regulation of T cell migration (GO:2000406)3.14550899
57defense response to fungus (GO:0050832)3.11092487
58positive regulation of interleukin-6 production (GO:0032755)2.91040049
59regulation of interleukin-17 production (GO:0032660)2.91000247
60regulation of T cell migration (GO:2000404)2.88930185
61regulation of transmission of nerve impulse (GO:0051969)2.88413455
62negative regulation of keratinocyte proliferation (GO:0010839)2.86967979
63positive regulation of epidermis development (GO:0045684)2.86600058
64phosphatidic acid biosynthetic process (GO:0006654)2.84796931
65phosphatidic acid metabolic process (GO:0046473)2.84796931
66regulation of natural killer cell activation (GO:0032814)2.81321124
67lateral sprouting from an epithelium (GO:0060601)2.76538296
68regulation of interleukin-6 production (GO:0032675)2.76320255
69epithelial cell differentiation (GO:0030855)2.75259522
70response to UV-B (GO:0010224)2.71782452
71intestinal epithelial cell development (GO:0060576)2.67113748
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66225323
734-hydroxyproline metabolic process (GO:0019471)2.63506915
74positive regulation of transforming growth factor beta production (GO:0071636)2.62222757
75regulation of T-helper 2 cell differentiation (GO:0045628)2.59153685
76regulation of p38MAPK cascade (GO:1900744)2.58656563
77eyelid development in camera-type eye (GO:0061029)2.55738116
78positive regulation of type 2 immune response (GO:0002830)2.52508491
79positive regulation of lymphocyte migration (GO:2000403)2.51817470
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50494358
81positive regulation of epidermal cell differentiation (GO:0045606)2.50321927
82regulation of axon regeneration (GO:0048679)2.49558166
83regulation of neuron projection regeneration (GO:0070570)2.49558166
84regulation of keratinocyte differentiation (GO:0045616)2.48327023
85regulation of glomerulus development (GO:0090192)2.47651677
86positive regulation of chemokine secretion (GO:0090197)2.46697225
87sphingolipid biosynthetic process (GO:0030148)2.46500691
88regulation of granulocyte chemotaxis (GO:0071622)2.45732520
89regulation of keratinocyte proliferation (GO:0010837)2.45724936
90response to zinc ion (GO:0010043)2.45601700
91protein hydroxylation (GO:0018126)2.44970920
92regulation of collagen biosynthetic process (GO:0032965)2.44561005
93male genitalia development (GO:0030539)2.41526136
94response to fungus (GO:0009620)2.40597020
95keratinization (GO:0031424)19.9080427
96establishment of skin barrier (GO:0061436)15.3148603
97keratinocyte differentiation (GO:0030216)13.3203909
98regulation of water loss via skin (GO:0033561)13.1527542
99desmosome organization (GO:0002934)10.4287596
100epidermal cell differentiation (GO:0009913)10.0753691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.20322595
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.86535058
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.71595344
4HIF1A_21447827_ChIP-Seq_MCF-7_Human3.09245760
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.78055678
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.78055678
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.48822357
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.20721745
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08520645
10TP63_23658742_ChIP-Seq_EP156T_Human2.07207436
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05816164
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.03402622
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.6437257
14SOX2_20726797_ChIP-Seq_SW620_Human1.95706678
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.87915377
16GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.82761275
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78203263
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76900016
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.76863107
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75894062
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63248765
22CJUN_26792858_Chip-Seq_BT549_Human1.61274101
23GATA6_21074721_ChIP-Seq_CACO-2_Human1.60255293
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.57087328
25ZNF263_19887448_ChIP-Seq_K562_Human1.56403718
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.55838801
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53100219
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51504973
29ERG_20517297_ChIP-Seq_VCAP_Human1.51414803
30RXR_22108803_ChIP-Seq_LS180_Human1.47852151
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47676949
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46003874
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43574768
34* ATF3_27146783_Chip-Seq_COLON_Human1.42114685
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36784905
36EGR1_19032775_ChIP-ChIP_M12_Human1.36151230
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35054285
38TP63_22573176_ChIP-Seq_HFKS_Human1.30363021
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26799304
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.24454543
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21243042
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20744247
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.13994117
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13580949
45RBPJ_21746931_ChIP-Seq_IB4_Human1.12226427
46TP53_16413492_ChIP-PET_HCT116_Human1.11000604
47KLF5_25053715_ChIP-Seq_YYC3_Human1.10670063
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10527235
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09709019
50AHR_22903824_ChIP-Seq_MCF-7_Human1.04885244
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04766278
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04144927
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02496104
54CLOCK_20551151_ChIP-Seq_293T_Human1.00488121
55TP53_18474530_ChIP-ChIP_U2OS_Human1.00012462
56GATA3_24758297_ChIP-Seq_MCF-7_Human0.99833328
57GATA4_25053715_ChIP-Seq_YYC3_Human0.97880613
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96629777
59GATA6_25053715_ChIP-Seq_YYC3_Human0.95636002
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94116019
61RACK7_27058665_Chip-Seq_MCF-7_Human0.94081418
62SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92550447
63RUNX1_27514584_Chip-Seq_MCF-7_Human0.91280841
64HNFA_21074721_ChIP-Seq_CACO-2_Human0.89721075
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88807199
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87381949
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86299579
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.84663909
69* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83459394
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82494008
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82426921
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82140473
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.81829697
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81693410
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81693410
76SMC4_20622854_ChIP-Seq_HELA_Human0.79640745
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79290714
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.79251589
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79087579
80NCOR_22424771_ChIP-Seq_293T_Human0.77511831
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77089927
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77042177
83CDX2_20551321_ChIP-Seq_CACO-2_Human0.75175222
84GATA2_19941826_ChIP-Seq_K562_Human0.75132390
85VDR_22108803_ChIP-Seq_LS180_Human0.74524490
86CDX2_22108803_ChIP-Seq_LS180_Human0.72788969
87CBX2_22325352_ChIP-Seq_293T-Rex_Human0.72013630
88E2F1_20622854_ChIP-Seq_HELA_Human0.71506959
89BCOR_27268052_Chip-Seq_Bcells_Human0.70424511
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69976461
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68970738
92PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.68401280
93CEBPB_22108803_ChIP-Seq_LS180_Human0.68206576
94P53_21459846_ChIP-Seq_SAOS-2_Human0.65226922
95CTCF_20526341_ChIP-Seq_ESCs_Human0.65096903
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64592788
97ETV1_20927104_ChIP-Seq_GIST48_Human0.63677497
98FOXA1_25552417_ChIP-Seq_VCAP_Human0.63241392
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.62003610
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.61713475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.12445718
2MP0005275_abnormal_skin_tensile6.83784651
3MP0000579_abnormal_nail_morphology6.37009175
4MP0010234_abnormal_vibrissa_follicle5.67107800
5MP0005501_abnormal_skin_physiology5.36728202
6MP0003453_abnormal_keratinocyte_physiol3.60188399
7MP0004885_abnormal_endolymph3.42569838
8MP0001216_abnormal_epidermal_layer3.30516665
9MP0003878_abnormal_ear_physiology3.16900004
10MP0005377_hearing/vestibular/ear_phenot3.16900004
11MP0002060_abnormal_skin_morphology3.02003271
12MP0003941_abnormal_skin_development2.97364308
13MP0010771_integument_phenotype2.88312958
14MP0010678_abnormal_skin_adnexa2.68132710
15MP0004264_abnormal_extraembryonic_tissu2.31502208
16MP0004947_skin_inflammation2.27648025
17MP0000383_abnormal_hair_follicle2.22814383
18MP0000467_abnormal_esophagus_morphology2.20957877
19MP0001188_hyperpigmentation2.04903987
20MP0003705_abnormal_hypodermis_morpholog2.01286150
21MP0003191_abnormal_cellular_cholesterol1.95997814
22MP0004381_abnormal_hair_follicle1.93121942
23MP0000762_abnormal_tongue_morphology1.84698116
24MP0005409_darkened_coat_color1.76401888
25MP0000377_abnormal_hair_follicle1.76347934
26MP0002098_abnormal_vibrissa_morphology1.74681592
27MP0009931_abnormal_skin_appearance1.68545700
28MP0004782_abnormal_surfactant_physiolog1.66709396
29MP0003566_abnormal_cell_adhesion1.51138766
30MP0003950_abnormal_plasma_membrane1.41551054
31MP0001191_abnormal_skin_condition1.38067714
32MP0005023_abnormal_wound_healing1.27569941
33MP0010352_gastrointestinal_tract_polyps1.23556845
34MP0000427_abnormal_hair_cycle1.14174199
35MP0000465_gastrointestinal_hemorrhage1.10600129
36MP0008004_abnormal_stomach_pH1.09954731
37MP0000367_abnormal_coat/_hair1.09715723
38MP0000647_abnormal_sebaceous_gland1.05027800
39MP0003011_delayed_dark_adaptation1.02806119
40MP0002095_abnormal_skin_pigmentation1.01726614
41MP0009053_abnormal_anal_canal1.00582879
42MP0000566_synostosis0.99326960
43MP0001851_eye_inflammation0.97517211
44MP0009379_abnormal_foot_pigmentation0.87854042
45MP0004043_abnormal_pH_regulation0.75048329
46MP0001784_abnormal_fluid_regulation0.73061328
47MP0006082_CNS_inflammation0.72987481
48MP0002006_tumorigenesis0.71966323
49MP0002177_abnormal_outer_ear0.71633192
50MP0004272_abnormal_basement_membrane0.63037817
51MP0004185_abnormal_adipocyte_glucose0.58855607
52MP0000627_abnormal_mammary_gland0.56243331
53MP0001243_abnormal_dermal_layer0.53859564
54MP0002111_abnormal_tail_morphology0.53045974
55MP0001485_abnormal_pinna_reflex0.51825080
56MP0000858_altered_metastatic_potential0.51512655
57MP0003300_gastrointestinal_ulcer0.48738508
58MP0002877_abnormal_melanocyte_morpholog0.44794183
59MP0009785_altered_susceptibility_to0.42423912
60MP0002332_abnormal_exercise_endurance0.41998084
61MP0003315_abnormal_perineum_morphology0.38737321
62MP0008260_abnormal_autophagy0.37507011
63MP0002234_abnormal_pharynx_morphology0.35804569
64MP0005387_immune_system_phenotype0.34863580
65MP0001790_abnormal_immune_system0.34863580
66MP0005166_decreased_susceptibility_to0.34658425
67MP0008438_abnormal_cutaneous_collagen0.34562635
68MP0002282_abnormal_trachea_morphology0.32930515
69MP0003448_altered_tumor_morphology0.32732791
70MP0003763_abnormal_thymus_physiology0.32409192
71MP0005666_abnormal_adipose_tissue0.32129335
72MP0003755_abnormal_palate_morphology0.32101304
73MP0009333_abnormal_splenocyte_physiolog0.32093213
74MP0000685_abnormal_immune_system0.31933219
75MP0005164_abnormal_response_to0.31746581
76MP0002009_preneoplasia0.29297761
77MP0005388_respiratory_system_phenotype0.27145730
78MP0002133_abnormal_respiratory_system0.27145730
79MP0001340_abnormal_eyelid_morphology0.26766238
80MP0002166_altered_tumor_susceptibility0.25694305
81MP0005375_adipose_tissue_phenotype0.25345958
82MP0001177_atelectasis0.24322637
83MP0001905_abnormal_dopamine_level0.24032868
84MP0003436_decreased_susceptibility_to0.23031478
85MP0000015_abnormal_ear_pigmentation0.20212060
86MP0002148_abnormal_hypersensitivity_rea0.20194000
87MP0000470_abnormal_stomach_morphology0.19077007
88MP0005197_abnormal_uvea_morphology0.18268176
89MP0005193_abnormal_anterior_eye0.18026200
90MP0003828_pulmonary_edema0.17556212
91MP0005257_abnormal_intraocular_pressure0.15946721
92MP0004197_abnormal_fetal_growth/weight/0.15433435
93MP0001765_abnormal_ion_homeostasis0.14623296
94MP0009780_abnormal_chondrocyte_physiolo0.14519290
95MP0010030_abnormal_orbit_morphology0.14190806
96MP0003091_abnormal_cell_migration0.14152018
97MP0005076_abnormal_cell_differentiation0.13830244
98MP0005025_abnormal_response_to0.13363064
99MP0001501_abnormal_sleep_pattern0.13262491
100MP0005174_abnormal_tail_pigmentation0.12902103

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)9.44636435
2Palmar hyperkeratosis (HP:0010765)8.98328423
3Erythroderma (HP:0001019)8.89298796
4Oral leukoplakia (HP:0002745)8.64932663
5Plantar hyperkeratosis (HP:0007556)7.69897546
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.27738347
7Increased IgE level (HP:0003212)7.25685605
8Alopecia of scalp (HP:0002293)7.20977794
9Congenital ichthyosiform erythroderma (HP:0007431)7.15918831
10Parakeratosis (HP:0001036)6.19130331
11Thick nail (HP:0001805)6.18609176
12Onycholysis (HP:0001806)5.91832326
13Erythema (HP:0010783)5.70995538
14Corneal erosion (HP:0200020)5.57316650
15Conjunctival hamartoma (HP:0100780)5.40836178
16Abnormality of secondary sexual hair (HP:0009888)5.28432932
17Abnormality of the axillary hair (HP:0100134)5.28432932
18Hypotrichosis (HP:0001006)5.03958373
19Gangrene (HP:0100758)4.43495157
20Ectropion (HP:0000656)4.22278856
21Palmoplantar keratoderma (HP:0000982)4.17200820
22Hypohidrosis (HP:0000966)4.16433923
23Follicular hyperkeratosis (HP:0007502)4.08188901
24Nail dystrophy (HP:0008404)4.02479148
25Abnormality of placental membranes (HP:0011409)4.01038531
26Amniotic constriction ring (HP:0009775)4.01038531
27Absent eyelashes (HP:0000561)3.74333226
28Sparse eyelashes (HP:0000653)3.72516895
29Right ventricular cardiomyopathy (HP:0011663)3.71936574
30Pustule (HP:0200039)3.63934954
31Hamartoma of the eye (HP:0010568)3.54746439
32Absent hair (HP:0002298)3.41044625
33Furrowed tongue (HP:0000221)3.34054200
34Abnormal blistering of the skin (HP:0008066)3.27562775
35Lip pit (HP:0100267)3.06811474
36Woolly hair (HP:0002224)2.91537807
37Autoamputation (HP:0001218)2.91051496
38Fragile nails (HP:0001808)2.86302989
39Abnormality of the salivary glands (HP:0010286)2.73983827
40Pruritus (HP:0000989)2.65878671
41Lack of skin elasticity (HP:0100679)2.60353522
42Recurrent corneal erosions (HP:0000495)2.58665637
43Multifactorial inheritance (HP:0001426)2.51318748
44Sparse scalp hair (HP:0002209)2.43336349
45Paralysis (HP:0003470)2.42552602
46Keratoconjunctivitis sicca (HP:0001097)2.41679380
47Blepharitis (HP:0000498)2.39403006
48Laryngomalacia (HP:0001601)2.35916414
49Pili torti (HP:0003777)2.28549911
50Urticaria (HP:0001025)2.27910326
51Ridged nail (HP:0001807)2.23699431
52Dehydration (HP:0001944)2.20183705
53Keratoconjunctivitis (HP:0001096)2.18933468
54Abnormal hair laboratory examination (HP:0003328)2.16820904
55Hyperhidrosis (HP:0000975)2.06729994
56Melanocytic nevus (HP:0000995)2.06059829
57Corneal dystrophy (HP:0001131)2.03267167
58Abnormality of nail color (HP:0100643)13.6011441
59Milia (HP:0001056)1.99483053
60Hypergammaglobulinemia (HP:0010702)1.98719518
61Recurrent bacterial skin infections (HP:0005406)1.95702022
62Skin ulcer (HP:0200042)1.84532960
63Natal tooth (HP:0000695)1.77575886
64Anonychia (HP:0001798)1.77454957
65Carious teeth (HP:0000670)1.75938826
66Brittle hair (HP:0002299)1.71855427
67Xerostomia (HP:0000217)1.71014118
68Eczematoid dermatitis (HP:0000976)1.70043976
69Hypoplastic labia majora (HP:0000059)1.65183551
70Sepsis (HP:0100806)1.62537868
71Papilloma (HP:0012740)1.60155002
72Verrucae (HP:0200043)1.60155002
73Hamartoma (HP:0010566)1.59068416
74Advanced eruption of teeth (HP:0006288)1.59009546
75Hypoplastic toenails (HP:0001800)1.58856054
76Preauricular skin tag (HP:0000384)1.58547420
77Abnormalities of placenta or umbilical cord (HP:0001194)1.55093984
78Abnormality of the fingernails (HP:0001231)1.54305708
79Abnormality of hair growth rate (HP:0011363)1.54116995
80Slow-growing hair (HP:0002217)1.54116995
81Dry skin (HP:0000958)1.53720048
82Selective tooth agenesis (HP:0001592)1.49492737
83Dry hair (HP:0011359)1.49031343
84Abnormality of the labia majora (HP:0012881)1.48865634
85Ankyloglossia (HP:0010296)1.46996407
86Squamous cell carcinoma (HP:0002860)1.46965550
87Fine hair (HP:0002213)1.46437049
88Knee flexion contracture (HP:0006380)1.33137179
89Skin tags (HP:0010609)1.30172127
90Split foot (HP:0001839)1.29002817
91Curly hair (HP:0002212)1.27993015
92Recurrent skin infections (HP:0001581)1.27082918
93Popliteal pterygium (HP:0009756)1.26478733
94Duplicated collecting system (HP:0000081)1.26318168
95Acanthocytosis (HP:0001927)1.21966790
96Acanthosis nigricans (HP:0000956)1.18806925
97Axonal loss (HP:0003447)1.17289029
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.12322785
99Ventricular tachycardia (HP:0004756)1.12012825
100Generalized hyperpigmentation (HP:0007440)1.11779059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR14.30491225
2MAP3K94.28441447
3EPHA24.02627050
4MST43.99299790
5MAP3K63.98682337
6LATS23.34429576
7EPHA33.32431500
8FER3.19408247
9MST1R2.84813527
10MAP3K22.32015185
11MAP3K32.30029125
12STK242.19151185
13EPHB12.19048633
14EPHB22.10085561
15LATS12.01714557
16FGFR41.93432422
17FGFR31.91344025
18RIPK11.89216863
19ERN11.84185603
20MAP3K131.80492081
21BCR1.76874483
22PBK1.70335371
23FGFR11.68937405
24ARAF1.55853434
25MAPKAPK31.49329837
26IRAK11.48584634
27SGK2231.41805294
28SGK4941.41805294
29IKBKB1.37792547
30MAP3K121.37735782
31MET1.27313322
32ERBB31.23131629
33STK38L1.19032608
34BMPR1B1.17884701
35GRK61.14883661
36TRPM71.11478218
37LMTK21.10160388
38PTK21.09547482
39IRAK31.04452213
40BMPR21.01840114
41MAP3K11.01650310
42SIK30.94607998
43BMX0.94577655
44NLK0.91499927
45MAP2K60.86512155
46MAPK70.72611945
47JAK30.71715137
48TAOK10.69671186
49STK380.67308357
50JAK10.63956207
51IKBKE0.63349560
52MAPKAPK20.62317976
53MARK20.61477392
54PIK3CA0.61313854
55MOS0.61146667
56NEK60.60953579
57STK30.59672795
58KSR20.59135998
59RET0.58250114
60GSK3A0.53042672
61SIK10.52608964
62PKN10.51619020
63PIM20.51091158
64EIF2AK30.50133146
65PDGFRA0.49091875
66PDGFRB0.48455776
67HIPK20.48074127
68CDK120.45520040
69CDK60.43035417
70BLK0.42582685
71PRKCE0.41990638
72MAP3K140.41604802
73CDK90.41187745
74PRPF4B0.41007696
75TYK20.40693665
76KIT0.38592175
77KSR10.37684895
78TAOK30.33215978
79MYLK0.33153972
80YES10.32096032
81ABL10.30907079
82MTOR0.30446563
83TGFBR20.29601774
84CDC42BPA0.28642899
85PRKCI0.27752405
86HCK0.27381560
87ABL20.23773831
88CSK0.22817727
89SGK10.22137520
90MAP3K70.21071798
91PAK40.20836224
92TAOK20.20780541
93CASK0.20750904
94PTK60.19869074
95PRKCD0.19499506
96ADRBK10.17990324
97PAK20.17868568
98IGF1R0.17438268
99CDK80.16632092
100FLT30.16254821

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005927.35338399
2Linoleic acid metabolism_Homo sapiens_hsa005916.14509274
3Ether lipid metabolism_Homo sapiens_hsa005654.28002698
4Arachidonic acid metabolism_Homo sapiens_hsa005904.03067945
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.16762752
6Ovarian steroidogenesis_Homo sapiens_hsa049132.17633457
7VEGF signaling pathway_Homo sapiens_hsa043702.05299061
8GnRH signaling pathway_Homo sapiens_hsa049122.00295346
9Sphingolipid metabolism_Homo sapiens_hsa006001.99475570
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.74949272
11Long-term depression_Homo sapiens_hsa047301.69815022
12Staphylococcus aureus infection_Homo sapiens_hsa051501.67474927
13Pertussis_Homo sapiens_hsa051331.67274345
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52236242
15Histidine metabolism_Homo sapiens_hsa003401.50622863
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43667681
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.41724656
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.40871000
19* Amoebiasis_Homo sapiens_hsa051461.31768735
20TNF signaling pathway_Homo sapiens_hsa046681.28025055
21Serotonergic synapse_Homo sapiens_hsa047261.22339686
22Choline metabolism in cancer_Homo sapiens_hsa052311.20159576
23Rheumatoid arthritis_Homo sapiens_hsa053231.16974054
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14933369
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09384913
26African trypanosomiasis_Homo sapiens_hsa051431.07818440
27Salmonella infection_Homo sapiens_hsa051321.07534824
28Ras signaling pathway_Homo sapiens_hsa040140.99360496
29Fat digestion and absorption_Homo sapiens_hsa049750.98657736
30Circadian rhythm_Homo sapiens_hsa047100.92855647
31Malaria_Homo sapiens_hsa051440.89956148
32Legionellosis_Homo sapiens_hsa051340.89298703
33Prion diseases_Homo sapiens_hsa050200.87501702
34Platelet activation_Homo sapiens_hsa046110.83973344
35HIF-1 signaling pathway_Homo sapiens_hsa040660.82547506
36Phototransduction_Homo sapiens_hsa047440.81127671
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78601522
38Phenylalanine metabolism_Homo sapiens_hsa003600.76057592
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74501161
40Influenza A_Homo sapiens_hsa051640.72596634
41Graft-versus-host disease_Homo sapiens_hsa053320.71952643
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.69784851
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65931675
44p53 signaling pathway_Homo sapiens_hsa041150.65330324
45Renal cell carcinoma_Homo sapiens_hsa052110.64302801
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63244402
47Pancreatic secretion_Homo sapiens_hsa049720.61504492
48Renin secretion_Homo sapiens_hsa049240.61067199
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60549802
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.60543334
51Glutamatergic synapse_Homo sapiens_hsa047240.58422036
52ECM-receptor interaction_Homo sapiens_hsa045120.53033956
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51752707
54MAPK signaling pathway_Homo sapiens_hsa040100.49371618
55Nitrogen metabolism_Homo sapiens_hsa009100.49231456
56Tuberculosis_Homo sapiens_hsa051520.48457831
57Oxytocin signaling pathway_Homo sapiens_hsa049210.48232575
58Acute myeloid leukemia_Homo sapiens_hsa052210.48029121
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.43320694
60Bladder cancer_Homo sapiens_hsa052190.42299265
61ErbB signaling pathway_Homo sapiens_hsa040120.41757387
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40988699
63Glioma_Homo sapiens_hsa052140.40822532
64Adherens junction_Homo sapiens_hsa045200.40702686
65MicroRNAs in cancer_Homo sapiens_hsa052060.38564034
66Dorso-ventral axis formation_Homo sapiens_hsa043200.37628366
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.37595793
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36721869
69Mineral absorption_Homo sapiens_hsa049780.36306336
70Sulfur metabolism_Homo sapiens_hsa009200.35193883
71Proteoglycans in cancer_Homo sapiens_hsa052050.35135995
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33600670
73Pancreatic cancer_Homo sapiens_hsa052120.32848579
74Retinol metabolism_Homo sapiens_hsa008300.32402195
75Hematopoietic cell lineage_Homo sapiens_hsa046400.32280061
76Hepatitis C_Homo sapiens_hsa051600.30204043
77FoxO signaling pathway_Homo sapiens_hsa040680.29558609
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.28557111
79Melanogenesis_Homo sapiens_hsa049160.27405330
80ABC transporters_Homo sapiens_hsa020100.26292500
81Shigellosis_Homo sapiens_hsa051310.24812715
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24382628
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24201144
84Gastric acid secretion_Homo sapiens_hsa049710.24167504
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.23843431
86Chemokine signaling pathway_Homo sapiens_hsa040620.21905983
87Galactose metabolism_Homo sapiens_hsa000520.21837900
88Toxoplasmosis_Homo sapiens_hsa051450.21718171
89Thyroid cancer_Homo sapiens_hsa052160.21700951
90Estrogen signaling pathway_Homo sapiens_hsa049150.20883324
91Long-term potentiation_Homo sapiens_hsa047200.20671646
92Measles_Homo sapiens_hsa051620.20550863
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20351872
94beta-Alanine metabolism_Homo sapiens_hsa004100.20076020
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.18286574
96Tight junction_Homo sapiens_hsa045300.18233154
97Pathways in cancer_Homo sapiens_hsa052000.17725766
98Tyrosine metabolism_Homo sapiens_hsa003500.17465834
99Fructose and mannose metabolism_Homo sapiens_hsa000510.17390027
100Rap1 signaling pathway_Homo sapiens_hsa040150.17324284

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