SERPINB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.88238168
2keratinocyte proliferation (GO:0043616)9.36351839
3bundle of His cell to Purkinje myocyte communication (GO:0086069)9.28948372
4multicellular organismal water homeostasis (GO:0050891)8.87413299
5epidermal cell differentiation (GO:0009913)8.71162504
6superoxide anion generation (GO:0042554)8.41023315
7gap junction assembly (GO:0016264)8.39171954
8hemidesmosome assembly (GO:0031581)7.97639261
9water homeostasis (GO:0030104)7.36491615
10keratinocyte development (GO:0003334)7.30957460
11epidermis development (GO:0008544)7.12276296
12establishment of tissue polarity (GO:0007164)6.80285497
13establishment of planar polarity (GO:0001736)6.80285497
14hair cycle (GO:0042633)6.51285948
15molting cycle (GO:0042303)6.51285948
16polarized epithelial cell differentiation (GO:0030859)6.24966759
17presynaptic membrane organization (GO:0097090)6.10778444
18lateral sprouting from an epithelium (GO:0060601)5.96108682
19intermediate filament organization (GO:0045109)5.76263046
20presynaptic membrane assembly (GO:0097105)5.38087575
21epithelial cell differentiation involved in prostate gland development (GO:0060742)5.28606117
22long-chain fatty acid biosynthetic process (GO:0042759)5.04277602
23intestinal epithelial cell development (GO:0060576)5.03888513
24negative regulation of keratinocyte proliferation (GO:0010839)4.56845477
25intermediate filament cytoskeleton organization (GO:0045104)4.48220989
26regulation of keratinocyte proliferation (GO:0010837)4.36052620
27intermediate filament-based process (GO:0045103)4.32435269
28surfactant homeostasis (GO:0043129)4.31817017
29positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.20876820
30regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.20876820
31positive regulation of cellular amide metabolic process (GO:0034250)4.20441751
32ectoderm development (GO:0007398)4.20248084
33lipoxygenase pathway (GO:0019372)4.18372969
34detection of molecule of bacterial origin (GO:0032490)4.14864743
35superoxide metabolic process (GO:0006801)4.07197099
36regulation of keratinocyte differentiation (GO:0045616)4.01897643
37eyelid development in camera-type eye (GO:0061029)4.01315308
38chemical homeostasis within a tissue (GO:0048875)3.90960758
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90183737
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.90183737
41modulation by symbiont of host immune response (GO:0052553)3.90183737
42positive regulation by symbiont of host defense response (GO:0052509)3.90183737
43modulation by symbiont of host defense response (GO:0052031)3.90183737
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90183737
45mesenchymal cell differentiation involved in renal system development (GO:2001012)3.88398597
46mesenchymal cell differentiation involved in kidney development (GO:0072161)3.88398597
47skeletal muscle tissue regeneration (GO:0043403)3.84557655
48hair follicle morphogenesis (GO:0031069)3.83676269
49response to gravity (GO:0009629)3.81754833
50negative regulation of interferon-gamma production (GO:0032689)3.80472061
51skin morphogenesis (GO:0043589)3.80263464
52negative regulation of mast cell activation (GO:0033004)3.79470391
53phosphatidylserine acyl-chain remodeling (GO:0036150)3.73014904
54cellular response to exogenous dsRNA (GO:0071360)3.72449083
55daunorubicin metabolic process (GO:0044597)3.72416821
56polyketide metabolic process (GO:0030638)3.72416821
57doxorubicin metabolic process (GO:0044598)3.72416821
58facial nerve structural organization (GO:0021612)3.66070798
59epithelial cell maturation (GO:0002070)3.64346803
60regulation of activation of Janus kinase activity (GO:0010533)3.61524820
61phosphatidylinositol acyl-chain remodeling (GO:0036149)3.58418626
62response to host immune response (GO:0052572)3.58136655
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58136655
64detection of other organism (GO:0098543)3.57019573
65endothelium development (GO:0003158)3.56050377
66regulation of interleukin-8 secretion (GO:2000482)3.51454537
67epithelium development (GO:0060429)3.50709107
68ventricular cardiac muscle cell action potential (GO:0086005)3.49888468
69histone H3-K36 demethylation (GO:0070544)3.49584508
70chronic inflammatory response (GO:0002544)3.43769703
71regulation of glomerular filtration (GO:0003093)3.39148387
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37447812
73regulation of epidermis development (GO:0045682)3.37141492
74cellular response to interferon-beta (GO:0035458)3.36599270
75linoleic acid metabolic process (GO:0043651)3.35457334
76planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33503287
77positive regulation of interleukin-1 beta secretion (GO:0050718)3.31881910
78regulation of non-canonical Wnt signaling pathway (GO:2000050)3.25867862
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23297486
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22569212
81positive regulation of monocyte chemotaxis (GO:0090026)3.22068138
82regulation of tight junction assembly (GO:2000810)3.20466294
83negative regulation of epidermis development (GO:0045683)3.18014438
84regulation of neuron projection regeneration (GO:0070570)3.17156223
85regulation of axon regeneration (GO:0048679)3.17156223
86genitalia morphogenesis (GO:0035112)3.17153023
87phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.14194209
88regulation of natural killer cell differentiation (GO:0032823)3.13603610
89adenine nucleotide transport (GO:0051503)3.13525420
90cardiac muscle cell action potential involved in contraction (GO:0086002)3.13229731
91negative regulation of stem cell proliferation (GO:2000647)3.12989372
92hair cycle process (GO:0022405)3.12147788
93molting cycle process (GO:0022404)3.12147788
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10298400
95sequestering of metal ion (GO:0051238)3.09385588
96negative regulation of epidermal cell differentiation (GO:0045605)3.09073834
97regulation of heart rate by cardiac conduction (GO:0086091)3.08190130
98G-protein coupled receptor internalization (GO:0002031)3.07564205
99one-carbon compound transport (GO:0019755)3.06594809
100positive regulation of protein sumoylation (GO:0033235)3.04967117
101purine ribonucleotide transport (GO:0015868)3.04460030
102cardiac muscle cell action potential (GO:0086001)3.04332542
103cellular extravasation (GO:0045123)3.03415347
104positive regulation of interleukin-1 secretion (GO:0050716)3.02959057
105extracellular regulation of signal transduction (GO:1900115)3.02366073
106extracellular negative regulation of signal transduction (GO:1900116)3.02366073
107positive regulation of epidermis development (GO:0045684)2.98474616
108negative regulation of cardiac muscle tissue growth (GO:0055022)2.98259490
109negative regulation of heart growth (GO:0061117)2.98259490
110replicative senescence (GO:0090399)2.98217333
111detection of external biotic stimulus (GO:0098581)2.98075357
112cerebral cortex radially oriented cell migration (GO:0021799)2.97958865
113regulation of epidermal cell differentiation (GO:0045604)2.97896960
114cell-cell junction assembly (GO:0007043)2.97671262
115cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.96893590
116response to peptidoglycan (GO:0032494)2.95081490
117detection of bacterium (GO:0016045)2.94295809
118positive regulation of epidermal cell differentiation (GO:0045606)2.93750498
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92825681
120response to host (GO:0075136)2.92825681
121response to host defenses (GO:0052200)2.92825681
122atrial cardiac muscle cell action potential (GO:0086014)2.89536444
123polyol transport (GO:0015791)2.88024416
124dendritic cell migration (GO:0036336)2.87997631
125cranial nerve structural organization (GO:0021604)2.87701720
126phosphatidylcholine acyl-chain remodeling (GO:0036151)2.86836862
127regulation of interleukin-1 beta secretion (GO:0050706)2.85212597
128regulation of ruffle assembly (GO:1900027)2.85034482
129mitotic G1 DNA damage checkpoint (GO:0031571)2.81744090
130opioid receptor signaling pathway (GO:0038003)2.79051179
131cell-substrate junction assembly (GO:0007044)2.78438608
132cell communication involved in cardiac conduction (GO:0086065)2.76858013
133G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75993834
134positive regulation of antigen processing and presentation (GO:0002579)2.75828682
135phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.73635099
136imidazole-containing compound metabolic process (GO:0052803)2.69523634
137negative regulation of cell aging (GO:0090344)2.69232916
138morphogenesis of embryonic epithelium (GO:0016331)2.69119844
139positive regulation of cAMP-mediated signaling (GO:0043950)2.66573368
140smooth muscle tissue development (GO:0048745)2.66346397
141epithelial cell differentiation (GO:0030855)2.65912413
142apical protein localization (GO:0045176)2.65606568
143cellular response to gamma radiation (GO:0071480)2.65157821
144ganglion development (GO:0061548)2.64855549
145microglial cell activation (GO:0001774)2.63998004
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63619399
147hair cell differentiation (GO:0035315)2.63381311
148detection of biotic stimulus (GO:0009595)2.62462689
149DNA integration (GO:0015074)2.61891410
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61753740
151positive regulation of T cell chemotaxis (GO:0010820)2.61678794
152regulation of T cell chemotaxis (GO:0010819)2.61678794
153cell proliferation in forebrain (GO:0021846)2.60385697
154sulfate transmembrane transport (GO:1902358)2.59490661
155neural tube formation (GO:0001841)2.58319379
156G1 DNA damage checkpoint (GO:0044783)2.57387153
157localization within membrane (GO:0051668)2.56079477
158natural killer cell activation involved in immune response (GO:0002323)2.55323788
159neutrophil activation (GO:0042119)2.52842439
160cilium or flagellum-dependent cell motility (GO:0001539)2.52609270
161dendritic cell chemotaxis (GO:0002407)2.49232846
162cellular anion homeostasis (GO:0030002)2.46738875
163sulfate transport (GO:0008272)2.45803143
164regulation of T-helper 1 cell differentiation (GO:0045625)2.40376542
165positive regulation of interleukin-8 secretion (GO:2000484)2.39265618
166female gonad development (GO:0008585)2.39022752
167macrophage activation involved in immune response (GO:0002281)2.38078548
168positive regulation of T-helper 1 type immune response (GO:0002827)2.37862570
169regulation of timing of cell differentiation (GO:0048505)2.37306659
170positive regulation of smooth muscle cell migration (GO:0014911)2.36451786
171regulation of interleukin-1 secretion (GO:0050704)2.34508863
172behavioral response to nicotine (GO:0035095)2.34319699
173phagosome maturation (GO:0090382)2.33260390
174positive regulation of interleukin-1 production (GO:0032732)2.32761150
175temperature homeostasis (GO:0001659)2.32056907
176positive regulation of interleukin-1 beta production (GO:0032731)2.32016632
177granulocyte activation (GO:0036230)2.31619568
178preassembly of GPI anchor in ER membrane (GO:0016254)2.29653027
179myeloid dendritic cell differentiation (GO:0043011)2.29226378
180regulation of antigen processing and presentation (GO:0002577)2.28695405
181positive regulation of interleukin-17 production (GO:0032740)2.28379576
182B cell proliferation (GO:0042100)2.27733606
183regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.26829085
184mitochondrion distribution (GO:0048311)2.26680107
185inositol phosphate-mediated signaling (GO:0048016)2.25789587
186negative regulation of viral genome replication (GO:0045071)2.25716722
187interferon-gamma production (GO:0032609)2.25630042
188cell differentiation involved in kidney development (GO:0061005)2.25501799
189tyrosine phosphorylation of STAT protein (GO:0007260)2.25440567
190detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.25048630
191limb bud formation (GO:0060174)2.24964217
192regulation of phospholipase A2 activity (GO:0032429)2.24501781
193sympathetic nervous system development (GO:0048485)2.24098089
194keratinization (GO:0031424)17.7944240
195establishment of skin barrier (GO:0061436)15.3246003
196desmosome organization (GO:0002934)14.7219818
197regulation of water loss via skin (GO:0033561)13.3370571
198keratinocyte differentiation (GO:0030216)11.2713856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.30697795
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.06727686
3GBX2_23144817_ChIP-Seq_PC3_Human3.97869689
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.49029254
5* ZFP57_27257070_Chip-Seq_ESCs_Mouse3.04033242
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.79216770
7* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.67388738
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.67388738
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.53024202
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.44985184
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.36275828
12* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.26418810
13TP63_23658742_ChIP-Seq_EP156T_Human2.24724744
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.18946686
15* NFE2_27457419_Chip-Seq_LIVER_Mouse2.16032486
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.12163102
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.11119352
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04657236
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04641885
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03443204
21TP63_17297297_ChIP-ChIP_HaCaT_Human15.4080899
22* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97634821
23* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.97220009
24* EZH2_27294783_Chip-Seq_NPCs_Mouse1.95708287
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94492319
26FUS_26573619_Chip-Seq_HEK293_Human1.94075051
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92481230
28* E2F1_18555785_Chip-Seq_ESCs_Mouse1.91734734
29EZH2_22144423_ChIP-Seq_EOC_Human1.90932930
30* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89969990
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.89158917
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87781811
33* NANOG_18555785_Chip-Seq_ESCs_Mouse1.87657704
34P300_19829295_ChIP-Seq_ESCs_Human1.87406862
35* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.86700066
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86185630
37* P53_22387025_ChIP-Seq_ESCs_Mouse1.84703277
38* STAT3_18555785_Chip-Seq_ESCs_Mouse1.82326754
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.80176684
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76691121
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76333208
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.75210522
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.74036048
44IGF1R_20145208_ChIP-Seq_DFB_Human1.73852929
45* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.73801988
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72356157
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72356157
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72283087
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71895702
50* NMYC_18555785_Chip-Seq_ESCs_Mouse1.71209683
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.68117205
52SMAD4_21799915_ChIP-Seq_A2780_Human1.67610211
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67345598
54* CMYC_18555785_Chip-Seq_ESCs_Mouse1.65881741
55* SOX2_18555785_Chip-Seq_ESCs_Mouse1.63606950
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63274171
57RNF2_27304074_Chip-Seq_NSC_Mouse1.63023294
58* PU1_27457419_Chip-Seq_LIVER_Mouse1.62839353
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62619713
60* OCT4_18555785_Chip-Seq_ESCs_Mouse1.60286765
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60183513
62* P300_18555785_Chip-Seq_ESCs_Mouse1.59807864
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59436267
64SOX2_20726797_ChIP-Seq_SW620_Human1.58241556
65* ZFX_18555785_Chip-Seq_ESCs_Mouse1.56693487
66* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56319339
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53560673
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53380277
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.52814725
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51217433
71CJUN_26792858_Chip-Seq_BT549_Human1.49581031
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.48371626
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.48316337
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48242807
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47573517
76* TAL1_26923725_Chip-Seq_HPCs_Mouse1.47302731
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46189184
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45905982
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45796245
80TP53_18474530_ChIP-ChIP_U2OS_Human1.44888401
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44879941
82* KLF4_18555785_Chip-Seq_ESCs_Mouse1.44248441
83* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.43535171
84AHR_22903824_ChIP-Seq_MCF-7_Human1.42343374
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42189541
86* CTCF_18555785_Chip-Seq_ESCs_Mouse1.42065691
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40140332
88* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.39606372
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.39538526
90* TP63_22573176_ChIP-Seq_HFKS_Human1.39381371
91* CRX_20693478_ChIP-Seq_RETINA_Mouse1.38926478
92* HTT_18923047_ChIP-ChIP_STHdh_Human1.38763212
93* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38394020
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.38253245
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36590628
96EWS_26573619_Chip-Seq_HEK293_Human1.36187411
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35639576
98* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34857279
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34798611
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34798611
101ER_23166858_ChIP-Seq_MCF-7_Human1.34447509
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33087113
103RXR_22108803_ChIP-Seq_LS180_Human1.32148763
104KLF5_25053715_ChIP-Seq_YYC3_Human1.30579868
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26756034
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26276067
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25220865
108STAT3_23295773_ChIP-Seq_U87_Human1.25051953
109GATA3_24758297_ChIP-Seq_MCF-7_Human1.24996364
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23783199
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.23635249
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23547703
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23503177
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22891897
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22833429
116DROSHA_22980978_ChIP-Seq_HELA_Human1.22819099
117* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22111453
118* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21320243
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20889975
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20889975
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.20875933
122TCF4_23295773_ChIP-Seq_U87_Human1.20517237
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18989231
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17707193
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.16901488
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15559697
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15310017
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14271438
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13829549
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12282266
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.11722252
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11284135
133RUNX2_22187159_ChIP-Seq_PCA_Human1.10935678
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10719249
135VDR_22108803_ChIP-Seq_LS180_Human1.10712100
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10019344
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09146995
138KDM2B_26808549_Chip-Seq_REH_Human1.08665346
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08203270
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05912263
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00952177
142TRIM28_21343339_ChIP-Seq_HEK293_Human1.00940654
143GATA6_21074721_ChIP-Seq_CACO-2_Human0.98916813
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98319018
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97943650
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.97881674
147GATA4_25053715_ChIP-Seq_YYC3_Human0.97299603
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94035721
149ATF3_27146783_Chip-Seq_COLON_Human0.91563289
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91391376
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86745670
152GATA6_25053715_ChIP-Seq_YYC3_Human0.86004394
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.84726519
154FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83067128
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82776770
156CLOCK_20551151_ChIP-Seq_293T_Human0.81694569
157RBPJ_21746931_ChIP-Seq_IB4_Human0.79618494
158AR_21572438_ChIP-Seq_LNCaP_Human0.79513484
159TP53_16413492_ChIP-PET_HCT116_Human0.79042951
160CDX2_22108803_ChIP-Seq_LS180_Human0.74701448
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74619076
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72555780
163RACK7_27058665_Chip-Seq_MCF-7_Human0.71812231
164* EGR1_19032775_ChIP-ChIP_M12_Human0.71465928
165FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71354301
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.70286584
167ETV1_20927104_ChIP-Seq_GIST48_Human0.69915749
168PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69319356
169ZNF263_19887448_ChIP-Seq_K562_Human0.68931286
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.67937594
171TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.67525139
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66345775
173PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66250430
174HNFA_21074721_ChIP-Seq_CACO-2_Human0.66105073
175CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64583867
176CEBPB_22108803_ChIP-Seq_LS180_Human0.64295791
177P53_22127205_ChIP-Seq_FIBROBLAST_Human0.64217744
178JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63478401
179FOXA1_25552417_ChIP-Seq_VCAP_Human0.60875291
180UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.60638478
181TCF4_22108803_ChIP-Seq_LS180_Human0.60492234
182GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.60183206
183RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60173705
184CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57914619
185P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56925454
186ERG_20517297_ChIP-Seq_VCAP_Human0.56817556
187CTNNB1_20460455_ChIP-Seq_HCT116_Human0.55907293
188BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53657190
189NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.53495017
190AR_25329375_ChIP-Seq_VCAP_Human0.52965262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.80491680
2MP0010234_abnormal_vibrissa_follicle5.99225368
3MP0005275_abnormal_skin_tensile5.54584329
4MP0005501_abnormal_skin_physiology4.89299169
5MP0001188_hyperpigmentation4.73290287
6MP0005171_absent_coat_pigmentation3.67246986
7MP0006292_abnormal_olfactory_placode3.52890152
8MP0003453_abnormal_keratinocyte_physiol3.51383992
9MP0010678_abnormal_skin_adnexa3.38530949
10MP0001216_abnormal_epidermal_layer3.34140991
11MP0005257_abnormal_intraocular_pressure3.16897835
12MP0002735_abnormal_chemical_nociception2.79885450
13MP0000467_abnormal_esophagus_morphology2.78294400
14MP0010771_integument_phenotype2.67279280
15MP0002277_abnormal_respiratory_mucosa2.58610881
16MP0002060_abnormal_skin_morphology2.57612918
17MP0005646_abnormal_pituitary_gland2.52369960
18MP0002876_abnormal_thyroid_physiology2.51293363
19MP0000566_synostosis2.45581492
20MP0004885_abnormal_endolymph2.38412905
21MP0002163_abnormal_gland_morphology2.29058049
22MP0009764_decreased_sensitivity_to2.23613902
23MP0008260_abnormal_autophagy2.20325330
24MP0003787_abnormal_imprinting2.17915062
25MP0001835_abnormal_antigen_presentation2.14933274
26MP0000377_abnormal_hair_follicle2.11625142
27MP0002148_abnormal_hypersensitivity_rea2.11331527
28MP0003878_abnormal_ear_physiology2.11067130
29MP0005377_hearing/vestibular/ear_phenot2.11067130
30MP0009697_abnormal_copulation2.09420263
31MP0003566_abnormal_cell_adhesion2.08144360
32MP0003724_increased_susceptibility_to2.07296396
33MP0005248_abnormal_Harderian_gland2.06749956
34MP0001346_abnormal_lacrimal_gland2.03507777
35MP0004264_abnormal_extraembryonic_tissu1.98796832
36MP0004742_abnormal_vestibular_system1.93079376
37MP0003941_abnormal_skin_development1.92739345
38MP0010386_abnormal_urinary_bladder1.91554858
39MP0004782_abnormal_surfactant_physiolog1.89110858
40MP0002132_abnormal_respiratory_system1.76064370
41MP0004947_skin_inflammation1.74322776
42MP0003705_abnormal_hypodermis_morpholog1.73987146
43MP0001986_abnormal_taste_sensitivity1.72594634
44MP0000015_abnormal_ear_pigmentation1.70857269
45MP0002249_abnormal_larynx_morphology1.69645681
46MP0005645_abnormal_hypothalamus_physiol1.65929265
47MP0005451_abnormal_body_composition1.65902371
48MP0009379_abnormal_foot_pigmentation1.63823136
49MP0001502_abnormal_circadian_rhythm1.62684308
50MP0002736_abnormal_nociception_after1.60836677
51MP0006082_CNS_inflammation1.60454683
52MP0005423_abnormal_somatic_nervous1.56264875
53MP0002638_abnormal_pupillary_reflex1.52499096
54MP0003136_yellow_coat_color1.51836923
55MP0009785_altered_susceptibility_to1.51424869
56MP0009931_abnormal_skin_appearance1.51362542
57MP0008058_abnormal_DNA_repair1.50343411
58MP0003191_abnormal_cellular_cholesterol1.48139208
59MP0003252_abnormal_bile_duct1.46676377
60MP0002102_abnormal_ear_morphology1.45062086
61MP0004043_abnormal_pH_regulation1.43485986
62MP0009053_abnormal_anal_canal1.41213594
63MP0000465_gastrointestinal_hemorrhage1.41192116
64MP0002938_white_spotting1.40051767
65MP0001191_abnormal_skin_condition1.39632317
66MP0003283_abnormal_digestive_organ1.38177787
67MP0005409_darkened_coat_color1.37968064
68MP0002419_abnormal_innate_immunity1.36730685
69MP0005310_abnormal_salivary_gland1.36181173
70MP0005671_abnormal_response_to1.35977933
71MP0010030_abnormal_orbit_morphology1.35134289
72MP0000383_abnormal_hair_follicle1.32935575
73MP0010352_gastrointestinal_tract_polyps1.31690751
74MP0001851_eye_inflammation1.29997578
75MP0000367_abnormal_coat/_hair1.28800423
76MP0003646_muscle_fatigue1.28489994
77MP0005379_endocrine/exocrine_gland_phen1.27693486
78MP0000569_abnormal_digit_pigmentation1.26042791
79MP0001968_abnormal_touch/_nociception1.24863211
80MP0002928_abnormal_bile_duct1.24393319
81MP0000647_abnormal_sebaceous_gland1.23545111
82MP0005503_abnormal_tendon_morphology1.23480344
83MP0004484_altered_response_of1.22715571
84MP0006276_abnormal_autonomic_nervous1.20530842
85MP0000681_abnormal_thyroid_gland1.18804946
86MP0005023_abnormal_wound_healing1.18196873
87MP0002877_abnormal_melanocyte_morpholog1.17430963
88MP0002254_reproductive_system_inflammat1.15411456
89MP0009384_cardiac_valve_regurgitation1.15403591
90MP0001440_abnormal_grooming_behavior1.15056728
91MP0000026_abnormal_inner_ear1.14829441
92MP0005387_immune_system_phenotype1.13810157
93MP0001790_abnormal_immune_system1.13810157
94MP0000579_abnormal_nail_morphology1.07844476
95MP0002733_abnormal_thermal_nociception1.07829098
96MP0003195_calcinosis1.06121008
97MP0003385_abnormal_body_wall1.00527740
98MP0004381_abnormal_hair_follicle0.98598665
99MP0002009_preneoplasia0.98378556
100MP0002234_abnormal_pharynx_morphology0.96436152
101MP0002177_abnormal_outer_ear0.91420953
102MP0002067_abnormal_sensory_capabilities0.91296146
103MP0005025_abnormal_response_to0.89297528
104MP0005000_abnormal_immune_tolerance0.88586886
105MP0002452_abnormal_antigen_presenting0.88411279
106MP0001800_abnormal_humoral_immune0.87764770
107MP0005647_abnormal_sex_gland0.85716956
108MP0003828_pulmonary_edema0.85348158
109MP0009278_abnormal_bone_marrow0.85169756
110MP0002095_abnormal_skin_pigmentation0.83809904
111MP0003303_peritoneal_inflammation0.83572164
112MP0000762_abnormal_tongue_morphology0.82920701
113MP0002933_joint_inflammation0.82873276
114MP0009780_abnormal_chondrocyte_physiolo0.82696450
115MP0004185_abnormal_adipocyte_glucose0.82593135
116MP0001119_abnormal_female_reproductive0.82208406
117MP0001486_abnormal_startle_reflex0.80810210
118MP0009745_abnormal_behavioral_response0.79929117
119MP0002557_abnormal_social/conspecific_i0.79135427
120MP0004019_abnormal_vitamin_homeostasis0.78561632
121MP0005174_abnormal_tail_pigmentation0.78273323
122MP0001243_abnormal_dermal_layer0.77927081
123MP0001501_abnormal_sleep_pattern0.77590934
124MP0001186_pigmentation_phenotype0.77167388
125MP0002723_abnormal_immune_serum0.75931097
126MP0001784_abnormal_fluid_regulation0.74003058
127MP0004134_abnormal_chest_morphology0.72387488
128MP0000678_abnormal_parathyroid_gland0.72051149
129MP0000427_abnormal_hair_cycle0.71793855
130MP0008789_abnormal_olfactory_epithelium0.71300072
131MP0003950_abnormal_plasma_membrane0.70850441
132MP0001853_heart_inflammation0.66073699
133MP0003868_abnormal_feces_composition0.65955298
134MP0002098_abnormal_vibrissa_morphology0.65399770
135MP0000490_abnormal_crypts_of0.65343315
136MP0002075_abnormal_coat/hair_pigmentati0.62501870
137MP0002998_abnormal_bone_remodeling0.62047329
138MP0000627_abnormal_mammary_gland0.61855764
139MP0001819_abnormal_immune_cell0.60386350
140MP0001542_abnormal_bone_strength0.59644368
141MP0001663_abnormal_digestive_system0.59501941
142MP0004130_abnormal_muscle_cell0.58894883
143MP0003315_abnormal_perineum_morphology0.56330991
144MP0003011_delayed_dark_adaptation0.55839662
145MP0001340_abnormal_eyelid_morphology0.52585348
146MP0003755_abnormal_palate_morphology0.50681550
147MP0002111_abnormal_tail_morphology0.46781108
148MP0003279_aneurysm0.46191672
149MP0001984_abnormal_olfaction0.46088410
150MP0000428_abnormal_craniofacial_morphol0.44538360
151MP0005394_taste/olfaction_phenotype0.44492249
152MP0005499_abnormal_olfactory_system0.44492249
153MP0002233_abnormal_nose_morphology0.44482358
154MP0005193_abnormal_anterior_eye0.42142062
155MP0003763_abnormal_thymus_physiology0.41869552
156MP0000750_abnormal_muscle_regeneration0.41597069
157MP0005197_abnormal_uvea_morphology0.39141843
158MP0000858_altered_metastatic_potential0.38430975
159MP0002133_abnormal_respiratory_system0.36722273
160MP0005388_respiratory_system_phenotype0.36722273
161MP0003638_abnormal_response/metabolism_0.36515816
162MP0002006_tumorigenesis0.36099722
163MP0002282_abnormal_trachea_morphology0.35275324
164MP0004197_abnormal_fetal_growth/weight/0.34478962
165MP0004272_abnormal_basement_membrane0.32453645
166MP0000470_abnormal_stomach_morphology0.30707368
167MP0000371_diluted_coat_color0.29939008
168MP0001299_abnormal_eye_distance/0.29378321
169MP0004215_abnormal_myocardial_fiber0.28966580
170MP0005508_abnormal_skeleton_morphology0.28919855
171MP0000432_abnormal_head_morphology0.28784354
172MP0002166_altered_tumor_susceptibility0.27335870
173MP0008438_abnormal_cutaneous_collagen0.26962837
174MP0004883_abnormal_blood_vessel0.26927264
175MP0008569_lethality_at_weaning0.25773350
176MP0003045_fibrosis0.21939996
177MP0005164_abnormal_response_to0.21868764
178MP0000049_abnormal_middle_ear0.19976433
179MP0000462_abnormal_digestive_system0.19354158

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.94745704
2Palmoplantar hyperkeratosis (HP:0000972)7.23006061
3Alopecia of scalp (HP:0002293)6.96453153
4Palmar hyperkeratosis (HP:0010765)6.93071625
5Abnormality of secondary sexual hair (HP:0009888)6.75115953
6Abnormality of the axillary hair (HP:0100134)6.75115953
7Chromosomal breakage induced by crosslinking agents (HP:0003221)6.54847644
8Plantar hyperkeratosis (HP:0007556)6.47007543
9Oral leukoplakia (HP:0002745)6.43622397
10Onycholysis (HP:0001806)6.24671452
11Erythroderma (HP:0001019)6.24217342
12Thick nail (HP:0001805)6.23236512
13Hypotrichosis (HP:0001006)5.99325071
14Increased IgE level (HP:0003212)5.81562575
15Chromsome breakage (HP:0040012)5.55578774
16Congenital ichthyosiform erythroderma (HP:0007431)5.14969248
17Right ventricular cardiomyopathy (HP:0011663)4.97428136
18Corneal erosion (HP:0200020)4.85050884
19Fragile nails (HP:0001808)4.81321363
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.33879820
21Lip pit (HP:0100267)4.32360749
22Woolly hair (HP:0002224)4.26457828
23Absent eyelashes (HP:0000561)4.21856267
24Selective tooth agenesis (HP:0001592)4.18149938
25Nail dystrophy (HP:0008404)4.10173241
26Thyroid-stimulating hormone excess (HP:0002925)3.95325764
27Duplicated collecting system (HP:0000081)3.94399113
28Sparse eyelashes (HP:0000653)3.88293796
29Erythema (HP:0010783)3.85398350
30Mesomelia (HP:0003027)3.84669362
31Sparse scalp hair (HP:0002209)3.79988215
32Abnormality of the salivary glands (HP:0010286)3.68648252
33Stomach cancer (HP:0012126)3.67770762
34Palmoplantar keratoderma (HP:0000982)3.62909068
35Optic neuritis (HP:0100653)3.55767631
36Retrobulbar optic neuritis (HP:0100654)3.55767631
37Milia (HP:0001056)3.54767908
38Hypoplastic labia majora (HP:0000059)3.54474711
39Parakeratosis (HP:0001036)3.50458362
40Absent hair (HP:0002298)3.46951620
41Febrile seizures (HP:0002373)3.43670322
42Abnormality of the renal collecting system (HP:0004742)3.41605687
43Septo-optic dysplasia (HP:0100842)3.28002209
44Aplasia involving bones of the extremities (HP:0009825)3.27737905
45Aplasia involving bones of the upper limbs (HP:0009823)3.27737905
46Aplasia of the phalanges of the hand (HP:0009802)3.27737905
47Tented upper lip vermilion (HP:0010804)3.25755888
48Myositis (HP:0100614)3.24058740
49Abnormality of the labia majora (HP:0012881)3.22763638
50Abnormal hair laboratory examination (HP:0003328)3.19830792
51Dry hair (HP:0011359)3.12083794
52Distal lower limb muscle weakness (HP:0009053)3.00463780
53Abnormal blistering of the skin (HP:0008066)2.96654057
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.96430767
55Ectopic kidney (HP:0000086)2.95264368
56Optic nerve hypoplasia (HP:0000609)2.94452858
57Abnormality of the dental root (HP:0006486)2.92973327
58Taurodontia (HP:0000679)2.92973327
59Abnormality of permanent molar morphology (HP:0011071)2.92973327
60Abnormal ciliary motility (HP:0012262)2.90253457
61Pili torti (HP:0003777)2.87711361
62Abnormality of molar (HP:0011077)2.75183739
63Abnormality of molar morphology (HP:0011070)2.75183739
64Oligodontia (HP:0000677)2.74372157
65Blepharitis (HP:0000498)2.74323338
66Abnormality of hair growth rate (HP:0011363)2.73902602
67Slow-growing hair (HP:0002217)2.73902602
68Orchitis (HP:0100796)2.73219610
69Abnormality of placental membranes (HP:0011409)2.72791741
70Amniotic constriction ring (HP:0009775)2.72791741
71Prostate neoplasm (HP:0100787)2.65756916
72Recurrent abscess formation (HP:0002722)2.64949146
73Eczematoid dermatitis (HP:0000976)2.64556409
74Ridged nail (HP:0001807)2.63386904
75Gangrene (HP:0100758)2.61312047
76Abnormality of the dental pulp (HP:0006479)2.61126828
77Abnormality of the preputium (HP:0100587)2.60455969
78True hermaphroditism (HP:0010459)2.57846238
79Abnormality of the ileum (HP:0001549)2.57179296
80Meckel diverticulum (HP:0002245)2.56434501
81Postaxial foot polydactyly (HP:0001830)2.55302419
82Abnormality of DNA repair (HP:0003254)2.54427315
83Short middle phalanx of the 5th finger (HP:0004220)2.53943044
84Increased IgM level (HP:0003496)2.53784771
85Hypergonadotropic hypogonadism (HP:0000815)2.53611001
86Duplication of thumb phalanx (HP:0009942)2.53227634
87Split foot (HP:0001839)2.49992339
88Nasolacrimal duct obstruction (HP:0000579)2.49320836
89Elevated erythrocyte sedimentation rate (HP:0003565)2.48592839
90Focal motor seizures (HP:0011153)2.43830092
91Furrowed tongue (HP:0000221)2.41115307
92Chronic hepatic failure (HP:0100626)2.36934622
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34621290
94Obstructive lung disease (HP:0006536)2.32894102
95Chronic obstructive pulmonary disease (HP:0006510)2.32894102
96Neoplasm of the adrenal cortex (HP:0100641)2.32110753
97Clubbing of toes (HP:0100760)2.30407564
98Alveolar cell carcinoma (HP:0006519)2.28192437
99Popliteal pterygium (HP:0009756)2.26163649
100Conical tooth (HP:0000698)2.25239338
101Abnormality of the nasal septum (HP:0000419)2.25203674
102Septate vagina (HP:0001153)2.25162366
103Preaxial hand polydactyly (HP:0001177)2.23646395
104Abnormality of the carotid arteries (HP:0005344)2.22230732
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.20452136
106Curly hair (HP:0002212)2.17255696
107Natal tooth (HP:0000695)2.16740755
108Pustule (HP:0200039)2.15263030
109Renal cortical cysts (HP:0000803)2.15029558
110Stomatitis (HP:0010280)2.14686724
111Recurrent bacterial skin infections (HP:0005406)2.14123623
112Labial hypoplasia (HP:0000066)2.13430792
113Hypoplasia of dental enamel (HP:0006297)2.13284720
114Neonatal hypoglycemia (HP:0001998)2.13076242
115Long nose (HP:0003189)2.10845965
116Congenital sensorineural hearing impairment (HP:0008527)2.10210073
117Inability to walk (HP:0002540)2.09662910
118Abnormal biliary tract physiology (HP:0012439)2.07530515
119Bile duct proliferation (HP:0001408)2.07530515
120Aplasia cutis congenita (HP:0001057)2.07274336
121Pruritus (HP:0000989)2.07169242
122Conjunctival hamartoma (HP:0100780)2.06719548
123Depressed nasal tip (HP:0000437)2.06551953
124Atrophic scars (HP:0001075)2.04741956
125Gingivitis (HP:0000230)2.03647830
126Abnormality of the renal cortex (HP:0011035)2.02469111
127White forelock (HP:0002211)2.01937074
128Recurrent corneal erosions (HP:0000495)2.01634163
129Follicular hyperkeratosis (HP:0007502)2.00819442
130Protruding tongue (HP:0010808)2.00675550
131Abnormality of the lacrimal duct (HP:0011481)1.99845256
132Pancreatic cysts (HP:0001737)1.99669385
133Autoamputation (HP:0001218)1.98517694
134Brittle hair (HP:0002299)1.98513173
135Patchy hypopigmentation of hair (HP:0011365)1.98480945
136Abnormal respiratory motile cilium physiology (HP:0012261)1.98366777
137Xerostomia (HP:0000217)1.98061649
138Systemic lupus erythematosus (HP:0002725)1.97610932
139Hypoplastic female external genitalia (HP:0012815)1.95412314
140Breast hypoplasia (HP:0003187)1.95310706
141Abnormality of chromosome stability (HP:0003220)1.95097741
142Retinal atrophy (HP:0001105)1.93041858
143Absent septum pellucidum (HP:0001331)1.90322046
144Hypohidrosis (HP:0000966)1.89840717
145Fine hair (HP:0002213)1.89808497
146Hepatoblastoma (HP:0002884)1.87550293
147Multifactorial inheritance (HP:0001426)1.87284904
148Intellectual disability, moderate (HP:0002342)1.86872810
149Tetraparesis (HP:0002273)1.85034475
150Anonychia (HP:0001798)1.85005361
151Abnormality of incisor morphology (HP:0011063)1.84957943
152Abnormality of the nasolacrimal system (HP:0000614)1.81756124
153Premature loss of primary teeth (HP:0006323)1.80009930
154Occipital encephalocele (HP:0002085)1.79756736
155Epileptic encephalopathy (HP:0200134)1.78157903
156Melanocytic nevus (HP:0000995)1.77148918
157Increased number of teeth (HP:0011069)1.76113968
158Keratoconjunctivitis sicca (HP:0001097)1.76043641
159Periodontitis (HP:0000704)1.75738515
160Hyperhidrosis (HP:0000975)1.75472952
161Carious teeth (HP:0000670)1.75105553
162Neoplasm of the tracheobronchial system (HP:0100552)1.74929403
163Duodenal stenosis (HP:0100867)1.74442574
164Small intestinal stenosis (HP:0012848)1.74442574
165Retinal dysplasia (HP:0007973)1.74415590
166Pancreatic fibrosis (HP:0100732)1.74379657
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.74109202
168Non-midline cleft lip (HP:0100335)1.72468623
169Advanced eruption of teeth (HP:0006288)1.72175909
170Nephronophthisis (HP:0000090)1.71949708
171Dynein arm defect of respiratory motile cilia (HP:0012255)1.71610282
172Absent/shortened dynein arms (HP:0200106)1.71610282
173Keratoconjunctivitis (HP:0001096)1.71454085
174Subacute progressive viral hepatitis (HP:0006572)1.70670789
175Urticaria (HP:0001025)1.70308783
176Dehydration (HP:0001944)1.69423318
177Astigmatism (HP:0000483)1.69313642
178Osteomalacia (HP:0002749)1.69111316
179Long clavicles (HP:0000890)1.67531784
180Abnormality of the septum pellucidum (HP:0007375)1.67373605
181Lack of skin elasticity (HP:0100679)1.67218437
182Laryngomalacia (HP:0001601)1.67177986
183Recurrent pneumonia (HP:0006532)1.66852356
184Acanthosis nigricans (HP:0000956)1.66175075
185Abnormal delayed hypersensitivity skin test (HP:0002963)1.65728128
186Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.65715763
187Erectile abnormalities (HP:0100639)1.65368858
188Absent speech (HP:0001344)1.64633642
189Ectropion (HP:0000656)1.63797556
190Short thumb (HP:0009778)1.63410905
191Anterior segment dysgenesis (HP:0007700)1.62800217
192Mediastinal lymphadenopathy (HP:0100721)1.61661175
193Cystic liver disease (HP:0006706)1.61422400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK247.59079699
2TGFBR15.46499334
3CASK4.84723562
4ZAK4.21930975
5EPHA24.03305114
6MAPKAPK33.95768356
7MAP3K143.75651751
8MAP3K23.73675408
9TXK3.37419506
10MAP3K63.11032462
11MST1R2.91872006
12MAP3K32.71438588
13IRAK32.68724687
14EIF2AK22.64774046
15TNIK2.53566419
16ADRBK22.48103560
17MAP2K72.20619603
18MAP3K92.11166183
19TAOK22.10546102
20RIPK11.99750335
21YES11.95511808
22FRK1.94708570
23STK31.86707763
24MET1.84273932
25INSRR1.84191697
26PINK11.71444087
27MAPK121.69524765
28SIK31.67000736
29FGFR11.65552496
30CCNB11.65061078
31PBK1.63225779
32SGK21.61944649
33TNK21.60616854
34EPHA31.59267341
35BCR1.54946325
36PRPF4B1.53849417
37FGFR31.45740735
38CDK31.43726621
39LATS11.41440791
40EPHA41.34834119
41STK161.31949985
42BMPR1B1.30302318
43DMPK1.26433162
44RPS6KB21.24871258
45BRSK21.19253150
46TGFBR21.18309417
47NUAK11.17414815
48IRAK41.17358835
49GRK61.14564199
50RIPK41.14421349
51AKT31.13654966
52MARK11.10117131
53SGK31.08157366
54FGR1.07163843
55GRK71.05209707
56ERBB30.97531152
57JAK30.97393663
58DAPK20.97383222
59STK38L0.97196079
60BMPR20.95563256
61BLK0.95322308
62SIK10.93579749
63FES0.92593626
64MAPK70.92224041
65TBK10.92193058
66FGFR20.91119195
67SGK2230.91016222
68SGK4940.91016222
69NTRK30.90092975
70NEK60.89133723
71RPS6KB10.87422388
72TEC0.85276500
73JAK10.85124593
74EPHB20.84625388
75PTK20.82291224
76BRD40.77013946
77LATS20.76176291
78MAPK130.76084047
79CLK10.75709077
80MUSK0.75602404
81CDK120.75433489
82MAP3K130.75033755
83ATR0.72389244
84PRKCH0.71559251
85PLK40.68082876
86GRK10.67273318
87TRPM70.67004006
88MAPK150.66728935
89PRKCE0.66639020
90PDK20.66223989
91PKN10.65212272
92CDK190.64837913
93LYN0.63838917
94EEF2K0.63194471
95EIF2AK30.62910413
96NLK0.61141126
97TTK0.60187809
98PLK20.59536197
99MAP2K60.58496917
100AKT20.57886306
101MAPKAPK50.57581412
102MST40.56766156
103IKBKB0.56707831
104CDK80.56243362
105SIK20.55268487
106KIT0.55040808
107OBSCN0.54976942
108PRKCD0.54327290
109MAPKAPK20.53162855
110ADRBK10.52831335
111MOS0.52314054
112STK100.51811475
113PRKCQ0.51445557
114MAP3K120.48573973
115PASK0.48298033
116HCK0.47497997
117PDGFRA0.47389048
118BRAF0.46888177
119CAMK40.45965701
120MAP3K10.44294743
121WNK10.43849299
122PRKCG0.43806699
123SGK10.43436476
124IGF1R0.43074579
125STK40.42173319
126IRAK10.41561639
127TAF10.40810908
128PDGFRB0.40700372
129FER0.40468811
130IKBKE0.40102584
131MAP3K70.39882215
132LRRK20.39133112
133OXSR10.39106306
134CHUK0.38962145
135CAMKK20.38760860
136CAMK2A0.38129140
137AKT10.37426371
138ERN10.37330524
139PIM20.37300612
140PRKG10.34925680
141NTRK10.34800402
142PIK3CG0.34629235
143MARK30.34134611
144TESK10.33435216
145ABL10.32656949
146CHEK20.32654222
147MKNK20.32452127
148MAP3K40.32175721
149CSK0.29571148
150ILK0.29340359
151ICK0.27646217
152PRKAA20.27285541
153NME10.26607240
154RPS6KA40.25876311
155TAOK10.25517697
156MTOR0.25368826
157CDK60.23884735
158MAPK90.22401750
159EPHB10.22077453
160FLT30.20051830
161CDC42BPA0.19815050
162RET0.15605727
163ERBB20.15060114
164GRK50.14707681
165IRAK20.14035590

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.57705001
2Autoimmune thyroid disease_Homo sapiens_hsa053203.24350093
3Graft-versus-host disease_Homo sapiens_hsa053322.98820739
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83084581
5Allograft rejection_Homo sapiens_hsa053302.40310355
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.35601379
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.28914429
8Circadian rhythm_Homo sapiens_hsa047102.22794786
9Rheumatoid arthritis_Homo sapiens_hsa053232.21265796
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18525635
11Collecting duct acid secretion_Homo sapiens_hsa049662.11886820
12Fanconi anemia pathway_Homo sapiens_hsa034602.08263085
13Dorso-ventral axis formation_Homo sapiens_hsa043202.08245565
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07614618
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06882086
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04530455
17Nicotine addiction_Homo sapiens_hsa050332.01951427
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.90591536
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87781664
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85511554
21VEGF signaling pathway_Homo sapiens_hsa043701.84225293
22GnRH signaling pathway_Homo sapiens_hsa049121.80364585
23Type I diabetes mellitus_Homo sapiens_hsa049401.79164158
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78121300
25Phagosome_Homo sapiens_hsa041451.76670501
26ECM-receptor interaction_Homo sapiens_hsa045121.75777907
27Measles_Homo sapiens_hsa051621.64540441
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64260422
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.60834384
30Renin secretion_Homo sapiens_hsa049241.58812723
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.54085544
32Staphylococcus aureus infection_Homo sapiens_hsa051501.50118139
33Morphine addiction_Homo sapiens_hsa050321.50080997
34Choline metabolism in cancer_Homo sapiens_hsa052311.47073677
35TNF signaling pathway_Homo sapiens_hsa046681.43528654
36Hematopoietic cell lineage_Homo sapiens_hsa046401.42081457
37* Amoebiasis_Homo sapiens_hsa051461.41838731
38Adherens junction_Homo sapiens_hsa045201.39892451
39Asthma_Homo sapiens_hsa053101.37700212
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33017921
41Tuberculosis_Homo sapiens_hsa051521.29642548
42Leishmaniasis_Homo sapiens_hsa051401.28956958
43Phenylalanine metabolism_Homo sapiens_hsa003601.25988618
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.23808996
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22451563
46MicroRNAs in cancer_Homo sapiens_hsa052061.18650546
47Taste transduction_Homo sapiens_hsa047421.17802728
48Long-term depression_Homo sapiens_hsa047301.17641953
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17171419
50Basal cell carcinoma_Homo sapiens_hsa052171.15242527
51Osteoclast differentiation_Homo sapiens_hsa043801.13579663
52Arachidonic acid metabolism_Homo sapiens_hsa005901.10485902
53Bladder cancer_Homo sapiens_hsa052191.06907636
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06396147
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06226657
56Herpes simplex infection_Homo sapiens_hsa051681.05924692
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04508707
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02064174
59Primary immunodeficiency_Homo sapiens_hsa053401.01382720
60Sphingolipid metabolism_Homo sapiens_hsa006001.00445087
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99033126
62Pancreatic cancer_Homo sapiens_hsa052120.97713478
63Thyroid cancer_Homo sapiens_hsa052160.97337320
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97237048
65Notch signaling pathway_Homo sapiens_hsa043300.96817818
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96574383
67Tight junction_Homo sapiens_hsa045300.96517514
68One carbon pool by folate_Homo sapiens_hsa006700.96452692
69Malaria_Homo sapiens_hsa051440.95261858
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.93657272
71Small cell lung cancer_Homo sapiens_hsa052220.93402119
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93209586
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92935804
74Retinol metabolism_Homo sapiens_hsa008300.92756424
75Chemokine signaling pathway_Homo sapiens_hsa040620.89671079
76Pancreatic secretion_Homo sapiens_hsa049720.89656569
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.89042504
78Pertussis_Homo sapiens_hsa051330.88354842
79p53 signaling pathway_Homo sapiens_hsa041150.88092376
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86761439
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86118816
82Proteoglycans in cancer_Homo sapiens_hsa052050.83571643
83Glioma_Homo sapiens_hsa052140.83143483
84Non-homologous end-joining_Homo sapiens_hsa034500.82338658
85Platelet activation_Homo sapiens_hsa046110.80874653
86Chemical carcinogenesis_Homo sapiens_hsa052040.80694144
87Olfactory transduction_Homo sapiens_hsa047400.79311915
88Salivary secretion_Homo sapiens_hsa049700.78950226
89Tyrosine metabolism_Homo sapiens_hsa003500.78402220
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77818474
91ABC transporters_Homo sapiens_hsa020100.77645197
92Influenza A_Homo sapiens_hsa051640.76053484
93Hippo signaling pathway_Homo sapiens_hsa043900.74856850
94Phototransduction_Homo sapiens_hsa047440.73087961
95Melanogenesis_Homo sapiens_hsa049160.72027058
96Glutamatergic synapse_Homo sapiens_hsa047240.71828218
97Other glycan degradation_Homo sapiens_hsa005110.71055920
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.69104850
99African trypanosomiasis_Homo sapiens_hsa051430.69048267
100Salmonella infection_Homo sapiens_hsa051320.68525349
101Endocytosis_Homo sapiens_hsa041440.68013131
102Ether lipid metabolism_Homo sapiens_hsa005650.67820423
103Regulation of autophagy_Homo sapiens_hsa041400.67695360
104Homologous recombination_Homo sapiens_hsa034400.67189314
105Axon guidance_Homo sapiens_hsa043600.65458340
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.65116385
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.64986489
108Circadian entrainment_Homo sapiens_hsa047130.63918585
109Legionellosis_Homo sapiens_hsa051340.62049497
110beta-Alanine metabolism_Homo sapiens_hsa004100.61708391
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61531944
112Focal adhesion_Homo sapiens_hsa045100.61452154
113Synaptic vesicle cycle_Homo sapiens_hsa047210.61396142
114Gastric acid secretion_Homo sapiens_hsa049710.60468606
115Ovarian steroidogenesis_Homo sapiens_hsa049130.60240920
116Hedgehog signaling pathway_Homo sapiens_hsa043400.59974634
117Inositol phosphate metabolism_Homo sapiens_hsa005620.59257123
118Vitamin digestion and absorption_Homo sapiens_hsa049770.58182548
119Acute myeloid leukemia_Homo sapiens_hsa052210.57947485
120Renal cell carcinoma_Homo sapiens_hsa052110.57576944
121Pathways in cancer_Homo sapiens_hsa052000.57569075
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56748774
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.56418871
124Melanoma_Homo sapiens_hsa052180.56379134
125Rap1 signaling pathway_Homo sapiens_hsa040150.55991372
126Protein digestion and absorption_Homo sapiens_hsa049740.55696345
127Serotonergic synapse_Homo sapiens_hsa047260.55450635
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54752771
129Apoptosis_Homo sapiens_hsa042100.54002604
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53556944
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.52090328
132ErbB signaling pathway_Homo sapiens_hsa040120.51771240
133Vibrio cholerae infection_Homo sapiens_hsa051100.50172600
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49391785
135Gap junction_Homo sapiens_hsa045400.48652777
136Calcium signaling pathway_Homo sapiens_hsa040200.48602309
137Oxytocin signaling pathway_Homo sapiens_hsa049210.48505761
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46562555
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46188811
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.45597361
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45338391
142Ras signaling pathway_Homo sapiens_hsa040140.45179576
143Insulin signaling pathway_Homo sapiens_hsa049100.45090868
144Selenocompound metabolism_Homo sapiens_hsa004500.44546805
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44023078
146Hepatitis B_Homo sapiens_hsa051610.43687420
147Hepatitis C_Homo sapiens_hsa051600.42685641
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42601184
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41959975
150Wnt signaling pathway_Homo sapiens_hsa043100.41818845
151Arginine biosynthesis_Homo sapiens_hsa002200.41178522
152Histidine metabolism_Homo sapiens_hsa003400.40565411
153Estrogen signaling pathway_Homo sapiens_hsa049150.40515649
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40268983
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39435827
156TGF-beta signaling pathway_Homo sapiens_hsa043500.39235632
157Toxoplasmosis_Homo sapiens_hsa051450.35386298
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35230850
159Steroid biosynthesis_Homo sapiens_hsa001000.34899247
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31261486
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31161686
162MAPK signaling pathway_Homo sapiens_hsa040100.31088662
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30925544
164cAMP signaling pathway_Homo sapiens_hsa040240.30569957
165Tryptophan metabolism_Homo sapiens_hsa003800.29789159

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