SERPINB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of bacterium (GO:0016045)8.62038843
2establishment of skin barrier (GO:0061436)8.59464882
3regulation of water loss via skin (GO:0033561)8.19480807
4detection of other organism (GO:0098543)7.54036450
5fatty acid elongation (GO:0030497)7.47495218
6keratinocyte differentiation (GO:0030216)7.33679726
7sphingoid metabolic process (GO:0046519)6.91403274
8peptide cross-linking (GO:0018149)6.90515266
9sphingosine metabolic process (GO:0006670)6.72380911
10multicellular organismal water homeostasis (GO:0050891)6.65441500
11regulation of dendritic cell antigen processing and presentation (GO:0002604)6.16470242
12diol metabolic process (GO:0034311)5.93354045
13phosphatidylserine acyl-chain remodeling (GO:0036150)5.86096072
14phosphatidylinositol acyl-chain remodeling (GO:0036149)5.82969457
15water homeostasis (GO:0030104)5.82589947
16positive regulation of Cdc42 GTPase activity (GO:0043089)5.62161308
17epidermal cell differentiation (GO:0009913)5.39445418
18positive regulation of antigen processing and presentation (GO:0002579)5.37533981
19regulation of natural killer cell differentiation (GO:0032823)5.29019875
20regulation of hypersensitivity (GO:0002883)5.13977551
21keratinocyte proliferation (GO:0043616)5.07993301
22intermediate filament cytoskeleton organization (GO:0045104)5.06661067
23long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.95430335
24negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.92454680
25cell wall macromolecule metabolic process (GO:0044036)4.91017056
26cell wall macromolecule catabolic process (GO:0016998)4.91017056
27intermediate filament-based process (GO:0045103)4.90881578
28long-chain fatty acid biosynthetic process (GO:0042759)4.90070255
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.83028085
30surfactant homeostasis (GO:0043129)4.77957290
31phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.77600993
32phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.59695031
33gap junction assembly (GO:0016264)4.53428960
34lipoxygenase pathway (GO:0019372)4.44810148
35fatty-acyl-CoA metabolic process (GO:0035337)4.38755929
36positive regulation of monocyte chemotaxis (GO:0090026)4.34607973
37negative regulation of interferon-gamma production (GO:0032689)4.29099228
38regulation of phospholipase A2 activity (GO:0032429)4.24330798
39regulation of antigen processing and presentation (GO:0002577)4.21916645
40phosphatidylcholine acyl-chain remodeling (GO:0036151)4.17560685
41negative regulation of keratinocyte proliferation (GO:0010839)4.12711243
42establishment of planar polarity (GO:0001736)4.12029906
43establishment of tissue polarity (GO:0007164)4.12029906
44ectoderm development (GO:0007398)4.10855145
45cardiolipin metabolic process (GO:0032048)4.05408966
46sequestering of metal ion (GO:0051238)4.05067510
47response to nitric oxide (GO:0071731)4.02658011
48positive regulation of T-helper 1 type immune response (GO:0002827)4.00860377
49linoleic acid metabolic process (GO:0043651)3.91831030
50positive regulation of T cell chemotaxis (GO:0010820)3.86684383
51regulation of T cell chemotaxis (GO:0010819)3.86684383
52regulation of T-helper 1 cell differentiation (GO:0045625)3.84299684
53epidermis development (GO:0008544)3.79906373
54positive regulation of granulocyte chemotaxis (GO:0071624)3.78831793
55lymph vessel development (GO:0001945)3.77524472
56epithelium development (GO:0060429)3.76509591
57glutathione biosynthetic process (GO:0006750)3.72163134
58regulation of keratinocyte differentiation (GO:0045616)3.72161071
59lateral sprouting from an epithelium (GO:0060601)3.70466142
60phosphatidylserine metabolic process (GO:0006658)3.65411389
61long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.65294294
62ceramide biosynthetic process (GO:0046513)3.62849177
63negative regulation of acute inflammatory response (GO:0002674)3.59029081
64interferon-gamma secretion (GO:0072643)3.54495429
65negative regulation of interleukin-17 production (GO:0032700)3.54027030
66polarized epithelial cell differentiation (GO:0030859)3.53895328
67fatty-acyl-CoA biosynthetic process (GO:0046949)3.52363411
68positive regulation of interleukin-4 production (GO:0032753)3.50645328
69positive regulation of epidermal cell differentiation (GO:0045606)3.48178777
70positive regulation of glycoprotein biosynthetic process (GO:0010560)3.47492156
71regulation of Cdc42 GTPase activity (GO:0043088)3.42646258
72skeletal muscle adaptation (GO:0043501)3.40336739
73detection of external biotic stimulus (GO:0098581)3.40316085
74negative regulation of T cell mediated immunity (GO:0002710)3.36611495
75intermediate filament organization (GO:0045109)3.35892851
76epithelial cell differentiation involved in prostate gland development (GO:0060742)3.35478045
77phospholipid efflux (GO:0033700)3.34917212
78nonribosomal peptide biosynthetic process (GO:0019184)3.33910128
79regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.32767203
80regulation of keratinocyte proliferation (GO:0010837)3.30595851
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.29788088
82hemidesmosome assembly (GO:0031581)3.28101803
83imidazole-containing compound metabolic process (GO:0052803)3.26894906
84response to muscle activity (GO:0014850)3.23110192
85regulation of ruffle assembly (GO:1900027)3.22338679
86positive regulation of cholesterol efflux (GO:0010875)3.22037329
87cellular protein complex localization (GO:0034629)3.20753995
88positive regulation of epidermis development (GO:0045684)3.20033612
89regulation of monocyte chemotaxis (GO:0090025)3.17059483
90skeletal muscle tissue regeneration (GO:0043403)3.16557830
91chemical homeostasis within a tissue (GO:0048875)3.15272527
92negative regulation of muscle hypertrophy (GO:0014741)3.12457582
93ventricular cardiac muscle cell action potential (GO:0086005)3.10102328
94primary alcohol catabolic process (GO:0034310)3.08391194
95regulation of glomerular filtration (GO:0003093)3.07529095
96skin morphogenesis (GO:0043589)3.07066192
97positive regulation of T-helper cell differentiation (GO:0045624)3.03749231
98phospholipid catabolic process (GO:0009395)3.03502999
99gland morphogenesis (GO:0022612)3.02233745
100striated muscle atrophy (GO:0014891)3.01840927
101very long-chain fatty acid metabolic process (GO:0000038)2.95685804
102heterotypic cell-cell adhesion (GO:0034113)2.95026142
103positive regulation of keratinocyte differentiation (GO:0045618)2.94338703
104negative regulation of interleukin-2 production (GO:0032703)2.94305458
105positive regulation of interleukin-1 beta secretion (GO:0050718)2.93792285
106alditol phosphate metabolic process (GO:0052646)2.91341411
107keratinocyte development (GO:0003334)2.90964173
108detection of biotic stimulus (GO:0009595)2.88042627
109positive regulation of mitochondrial membrane permeability (GO:0035794)2.86404060
110positive regulation of glycoprotein metabolic process (GO:1903020)2.82080687
111positive regulation of sterol transport (GO:0032373)2.81236468
112positive regulation of cholesterol transport (GO:0032376)2.81236468
113protein localization to endosome (GO:0036010)2.80655910
114renal system process involved in regulation of blood volume (GO:0001977)2.78665204
115atrioventricular valve morphogenesis (GO:0003181)2.78032687
116regulation of T-helper 1 type immune response (GO:0002825)2.76679536
117regulation of natural killer cell activation (GO:0032814)2.75944563
118positive regulation of vesicle fusion (GO:0031340)2.75164604
119hair follicle morphogenesis (GO:0031069)2.72150491
120positive regulation of interleukin-1 secretion (GO:0050716)2.71723322
121negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.70629438
122positive regulation of interleukin-1 beta production (GO:0032731)2.70344118
123regulation of skeletal muscle cell differentiation (GO:2001014)2.69890911
124regulation of epidermis development (GO:0045682)2.68311171
125regulation of protein localization to cell surface (GO:2000008)2.67463385
126negative regulation of skeletal muscle tissue development (GO:0048642)2.67351566
127regulation of heart rate by cardiac conduction (GO:0086091)2.65678138
128glucosamine-containing compound catabolic process (GO:1901072)2.65580861
129acyl-CoA biosynthetic process (GO:0071616)2.64651802
130thioester biosynthetic process (GO:0035384)2.64651802
131hair cycle (GO:0042633)2.64203640
132molting cycle (GO:0042303)2.64203640
133eyelid development in camera-type eye (GO:0061029)2.64127158
134cyclooxygenase pathway (GO:0019371)2.63637220
135phosphatidylglycerol metabolic process (GO:0046471)2.62189569
136epithelial cell differentiation (GO:0030855)2.60607561
137skin development (GO:0043588)2.59780530
138regulation of epidermal cell differentiation (GO:0045604)2.57881901
139regulation of cholesterol homeostasis (GO:2000188)2.57812657
140regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.55701805
141intestinal epithelial cell development (GO:0060576)2.54801413
142ethanol metabolic process (GO:0006067)2.54687841
143regulation of interleukin-1 beta secretion (GO:0050706)2.53843841
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53233745
145cell communication involved in cardiac conduction (GO:0086065)2.52999004
146regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48308794
147sphingolipid biosynthetic process (GO:0030148)2.44900405
148response to UV-B (GO:0010224)2.37749672
149defense response to fungus (GO:0050832)2.37116281
150positive regulation of cell cycle checkpoint (GO:1901978)2.31517779
151cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.29559576
152regulation of lymphocyte chemotaxis (GO:1901623)2.28550637
153regulation of neuron projection regeneration (GO:0070570)2.27764149
154regulation of axon regeneration (GO:0048679)2.27764149
155one-carbon compound transport (GO:0019755)2.25953235
156epithelial cell proliferation (GO:0050673)2.21700756
157polyol transport (GO:0015791)2.19122547
158cardiac conduction (GO:0061337)2.15809210
159epithelial cell-cell adhesion (GO:0090136)2.13794798
160hair cycle process (GO:0022405)2.07117728
161molting cycle process (GO:0022404)2.07117728
162unsaturated fatty acid biosynthetic process (GO:0006636)2.06849962
163keratinization (GO:0031424)12.5397354
164desmosome organization (GO:0002934)10.1562414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.76182009
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.70529098
3GATA1_22025678_ChIP-Seq_K562_Human2.59787162
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57589018
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.54975450
6P63_26484246_Chip-Seq_KERATINOCYTES_Human2.25779078
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.19964005
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.07277225
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06826651
10TP63_17297297_ChIP-ChIP_HaCaT_Human12.6271304
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.86031842
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77039829
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72698523
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62120291
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61348160
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.56174046
17SOX2_20726797_ChIP-Seq_SW620_Human1.55876421
18CJUN_26792858_Chip-Seq_BT549_Human1.53542494
19TP63_23658742_ChIP-Seq_EP156T_Human1.51167405
20EGR1_19032775_ChIP-ChIP_M12_Human1.50997128
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46384864
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43049456
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43049456
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42788464
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.31389933
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.30352772
27BCAT_22108803_ChIP-Seq_LS180_Human1.30069209
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27612805
29AR_21572438_ChIP-Seq_LNCaP_Human1.26243115
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25597072
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20758810
32GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16924827
33UBF1/2_26484160_Chip-Seq_HMECs_Human1.13601468
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04559293
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04461954
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04411614
37TP53_18474530_ChIP-ChIP_U2OS_Human1.03035914
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03022021
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00588746
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00449068
41PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99565129
42TP63_22573176_ChIP-Seq_HFKS_Human0.98578095
43DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97632058
44AHR_22903824_ChIP-Seq_MCF-7_Human0.97045591
45KLF5_25053715_ChIP-Seq_YYC3_Human0.96370838
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96361073
47GATA2_21666600_ChIP-Seq_HMVEC_Human0.96043023
48RXR_22108803_ChIP-Seq_LS180_Human0.93741416
49STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92893303
50AR_25329375_ChIP-Seq_VCAP_Human0.92412416
51GATA6_21074721_ChIP-Seq_CACO-2_Human0.91978581
52E2F1_20622854_ChIP-Seq_HELA_Human0.91370593
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91282138
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91195458
55ESR1_20079471_ChIP-ChIP_T-47D_Human0.90224416
56PIAS1_25552417_ChIP-Seq_VCAP_Human0.89380001
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88721729
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88302712
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87058216
60EED_16625203_ChIP-ChIP_MESCs_Mouse0.86857545
61CTCF_27219007_Chip-Seq_Bcells_Human0.86334511
62VDR_22108803_ChIP-Seq_LS180_Human0.86266138
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85887000
64GATA4_25053715_ChIP-Seq_YYC3_Human0.85694986
65CEBPB_22108803_ChIP-Seq_LS180_Human0.85609719
66JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84830090
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84819114
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83888469
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83797609
70P53_21459846_ChIP-Seq_SAOS-2_Human0.83480616
71CTCF_20526341_ChIP-Seq_ESCs_Human0.82896970
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82896673
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82822673
74RBPJ_21746931_ChIP-Seq_IB4_Human0.82646463
75JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82511846
76GATA3_24758297_ChIP-Seq_MCF-7_Human0.82495044
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82413691
78HNFA_21074721_ChIP-Seq_CACO-2_Human0.82337674
79P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82320110
80SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82229898
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.81775659
82EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80983600
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80983600
84SMC4_20622854_ChIP-Seq_HELA_Human0.80887313
85HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80414255
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79670039
87ZNF263_19887448_ChIP-Seq_K562_Human0.79485207
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79447575
89CLOCK_20551151_ChIP-Seq_293T_Human0.78844522
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78218142
91CDX2_22108803_ChIP-Seq_LS180_Human0.77113345
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.76751996
93BCOR_27268052_Chip-Seq_Bcells_Human0.76677933
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.75934513
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.75934513
96TCF4_22108803_ChIP-Seq_LS180_Human0.75754889
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74955124
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74891566
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.74539214
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74523019
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74487808
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74219358
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.74083165
104GATA6_25053715_ChIP-Seq_YYC3_Human0.74005309
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73950000
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73764809
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73237916
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.73050542
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72112226
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72112226
111ERG_20517297_ChIP-Seq_VCAP_Human0.71293223
112RACK7_27058665_Chip-Seq_MCF-7_Human0.71136802
113TP53_16413492_ChIP-PET_HCT116_Human0.71079701
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70252555
115GATA2_19941826_ChIP-Seq_K562_Human0.70092925
116BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69652765
117DROSHA_22980978_ChIP-Seq_HELA_Human0.69485794
118GATA3_21878914_ChIP-Seq_MCF-7_Human0.68534778
119ATF3_27146783_Chip-Seq_COLON_Human0.68448374
120OCT1_27270436_Chip-Seq_PROSTATE_Human0.68256948
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.67330332
122SMAD4_21741376_ChIP-Seq_ESCs_Human0.67269945
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66923264
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66821438
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.65299827
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.65078290
127MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.65042751
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64824988
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.64636204
130SMAD4_21799915_ChIP-Seq_A2780_Human0.64472424
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.63892397
132RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63300948
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.61627690
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.60954240
135* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60893915
136TAF2_19829295_ChIP-Seq_ESCs_Human0.60613588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.45526017
2MP0010234_abnormal_vibrissa_follicle5.96693389
3MP0002254_reproductive_system_inflammat5.55464423
4MP0005275_abnormal_skin_tensile5.18354633
5MP0005501_abnormal_skin_physiology4.72811686
6MP0001346_abnormal_lacrimal_gland4.44470100
7MP0000467_abnormal_esophagus_morphology3.06753935
8MP0010678_abnormal_skin_adnexa2.93308897
9MP0001216_abnormal_epidermal_layer2.87710763
10MP0004381_abnormal_hair_follicle2.71688675
11MP0000383_abnormal_hair_follicle2.66321269
12MP0010771_integument_phenotype2.58376539
13MP0003453_abnormal_keratinocyte_physiol2.55405190
14MP0004885_abnormal_endolymph2.54228520
15MP0005377_hearing/vestibular/ear_phenot2.47819696
16MP0003878_abnormal_ear_physiology2.47819696
17MP0002098_abnormal_vibrissa_morphology2.46055017
18MP0003191_abnormal_cellular_cholesterol2.38575392
19MP0000579_abnormal_nail_morphology2.37966497
20MP0003941_abnormal_skin_development2.23183791
21MP0002060_abnormal_skin_morphology2.18553689
22MP0001188_hyperpigmentation2.14056073
23MP0004185_abnormal_adipocyte_glucose2.12874420
24MP0005409_darkened_coat_color1.97551681
25MP0005451_abnormal_body_composition1.97531619
26MP0003566_abnormal_cell_adhesion1.90857016
27MP0000647_abnormal_sebaceous_gland1.86278071
28MP0005647_abnormal_sex_gland1.83572857
29MP0004947_skin_inflammation1.81587915
30MP0000377_abnormal_hair_follicle1.78020880
31MP0000762_abnormal_tongue_morphology1.74721229
32MP0002138_abnormal_hepatobiliary_system1.67036818
33MP0000015_abnormal_ear_pigmentation1.65668670
34MP0000685_abnormal_immune_system1.59695869
35MP0000427_abnormal_hair_cycle1.54567669
36MP0002249_abnormal_larynx_morphology1.50758095
37MP0001191_abnormal_skin_condition1.46940912
38MP0005174_abnormal_tail_pigmentation1.46277470
39MP0003011_delayed_dark_adaptation1.41005981
40MP0004782_abnormal_surfactant_physiolog1.37978638
41MP0002234_abnormal_pharynx_morphology1.34442858
42MP0001243_abnormal_dermal_layer1.31656934
43MP0009931_abnormal_skin_appearance1.29060378
44MP0009379_abnormal_foot_pigmentation1.27583918
45MP0001851_eye_inflammation1.25591453
46MP0002877_abnormal_melanocyte_morpholog1.22409236
47MP0001873_stomach_inflammation1.20499883
48MP0003136_yellow_coat_color1.12540369
49MP0003705_abnormal_hypodermis_morpholog1.10410496
50MP0005367_renal/urinary_system_phenotyp1.08236354
51MP0000516_abnormal_urinary_system1.08236354
52MP0003436_decreased_susceptibility_to1.06449628
53MP0002009_preneoplasia1.05583518
54MP0010352_gastrointestinal_tract_polyps1.05454249
55MP0002876_abnormal_thyroid_physiology1.05431946
56MP0000470_abnormal_stomach_morphology1.01825478
57MP0001348_abnormal_lacrimal_gland1.00025043
58MP0000613_abnormal_salivary_gland0.99599636
59MP0000566_synostosis0.97452850
60MP0000367_abnormal_coat/_hair0.96057370
61MP0002160_abnormal_reproductive_system0.92772247
62MP0002095_abnormal_skin_pigmentation0.91414712
63MP0003646_muscle_fatigue0.89745479
64MP0005171_absent_coat_pigmentation0.87614934
65MP0000569_abnormal_digit_pigmentation0.87376029
66MP0002090_abnormal_vision0.85622723
67MP0005075_abnormal_melanosome_morpholog0.85546071
68MP0001340_abnormal_eyelid_morphology0.85177522
69MP0009053_abnormal_anal_canal0.79971509
70MP0000538_abnormal_urinary_bladder0.78872019
71MP0000751_myopathy0.75816503
72MP0010030_abnormal_orbit_morphology0.74553928
73MP0004264_abnormal_extraembryonic_tissu0.72548102
74MP0005076_abnormal_cell_differentiation0.68403249
75MP0005023_abnormal_wound_healing0.67036668
76MP0004272_abnormal_basement_membrane0.66357659
77MP0002282_abnormal_trachea_morphology0.66283320
78MP0000627_abnormal_mammary_gland0.66157537
79MP0002971_abnormal_brown_adipose0.65974425
80MP0005623_abnormal_meninges_morphology0.62691348
81MP0003045_fibrosis0.60912112
82MP0006054_spinal_hemorrhage0.60518581
83MP0002148_abnormal_hypersensitivity_rea0.58293565
84MP0003638_abnormal_response/metabolism_0.57846378
85MP0009250_abnormal_appendicular_skeleto0.57445182
86MP0001784_abnormal_fluid_regulation0.56651784
87MP0002177_abnormal_outer_ear0.54494294
88MP0000372_irregular_coat_pigmentation0.51832732
89MP0005257_abnormal_intraocular_pressure0.50813008
90MP0008004_abnormal_stomach_pH0.49443632
91MP0005666_abnormal_adipose_tissue0.47224618
92MP0002006_tumorigenesis0.46151171
93MP0003718_maternal_effect0.46096138
94MP0000465_gastrointestinal_hemorrhage0.44234854
95MP0009780_abnormal_chondrocyte_physiolo0.42479094
96MP0002106_abnormal_muscle_physiology0.42186052
97MP0005248_abnormal_Harderian_gland0.41203716
98MP0009384_cardiac_valve_regurgitation0.40951945
99MP0002108_abnormal_muscle_morphology0.39222001
100MP0008438_abnormal_cutaneous_collagen0.39156723
101MP0005408_hypopigmentation0.39128206
102MP0009333_abnormal_splenocyte_physiolog0.38557363
103MP0001186_pigmentation_phenotype0.37479815
104MP0001177_atelectasis0.37187351
105MP0004036_abnormal_muscle_relaxation0.37075123
106MP0001984_abnormal_olfaction0.36178600
107MP0002166_altered_tumor_susceptibility0.35497178
108MP0004510_myositis0.35344019
109MP0005503_abnormal_tendon_morphology0.35185612
110MP0004145_abnormal_muscle_electrophysio0.35150576
111MP0001485_abnormal_pinna_reflex0.35126578
112MP0003755_abnormal_palate_morphology0.34915000
113MP0002277_abnormal_respiratory_mucosa0.34865962
114MP0000343_altered_response_to0.33860448
115MP0003890_abnormal_embryonic-extraembry0.33853777
116MP0002837_dystrophic_cardiac_calcinosis0.33258641
117MP0005369_muscle_phenotype0.32698866
118MP0005508_abnormal_skeleton_morphology0.32593190
119MP0005389_reproductive_system_phenotype0.32361500
120MP0003763_abnormal_thymus_physiology0.32342220
121MP0001881_abnormal_mammary_gland0.32296128
122MP0003315_abnormal_perineum_morphology0.31610431
123MP0002111_abnormal_tail_morphology0.31384640
124MP0003828_pulmonary_edema0.29912340
125MP0005388_respiratory_system_phenotype0.29148235
126MP0002133_abnormal_respiratory_system0.29148235
127MP0002092_abnormal_eye_morphology0.28709868
128MP0003950_abnormal_plasma_membrane0.26775892
129MP0000371_diluted_coat_color0.22506256
130MP0008789_abnormal_olfactory_epithelium0.20763129
131MP0004197_abnormal_fetal_growth/weight/0.20684209
132MP0002075_abnormal_coat/hair_pigmentati0.19627400
133MP0003300_gastrointestinal_ulcer0.19367415
134MP0005394_taste/olfaction_phenotype0.18824705
135MP0005499_abnormal_olfactory_system0.18824705
136MP0005193_abnormal_anterior_eye0.18438830
137MP0002697_abnormal_eye_size0.17349115
138MP0008569_lethality_at_weaning0.17157582
139MP0000432_abnormal_head_morphology0.14564195
140MP0005375_adipose_tissue_phenotype0.12785080
141MP0002233_abnormal_nose_morphology0.12591994
142MP0001299_abnormal_eye_distance/0.12572743
143MP0000428_abnormal_craniofacial_morphol0.11678108
144MP0005197_abnormal_uvea_morphology0.10661998

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.45170976
2Oral leukoplakia (HP:0002745)6.52466587
3Alopecia of scalp (HP:0002293)6.51788683
4Erythema (HP:0010783)5.80766832
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.80110142
6Right ventricular cardiomyopathy (HP:0011663)5.50460975
7Congenital ichthyosiform erythroderma (HP:0007431)5.27724395
8Hypotrichosis (HP:0001006)5.00022172
9Woolly hair (HP:0002224)4.95331509
10Palmoplantar hyperkeratosis (HP:0000972)4.73788779
11Plantar hyperkeratosis (HP:0007556)4.68608441
12Palmar hyperkeratosis (HP:0010765)4.37572040
13Erythroderma (HP:0001019)4.24722055
14Lip pit (HP:0100267)4.11065783
15Parakeratosis (HP:0001036)3.74241068
16Onycholysis (HP:0001806)3.59102955
17Absent eyelashes (HP:0000561)3.51752279
18Hypohidrosis (HP:0000966)3.50609599
19Gangrene (HP:0100758)3.38715103
20Follicular hyperkeratosis (HP:0007502)3.38000826
21Conjunctival hamartoma (HP:0100780)3.32154497
22Absent hair (HP:0002298)3.23502236
23Hyporeflexia of lower limbs (HP:0002600)3.23127914
24Severe Myopia (HP:0011003)3.22228167
25Corneal erosion (HP:0200020)3.17262121
26Hypergammaglobulinemia (HP:0010702)3.13230232
27Pruritus (HP:0000989)3.13005791
28Curly hair (HP:0002212)3.11591263
29Abnormality of the salivary glands (HP:0010286)3.10629192
30Eczematoid dermatitis (HP:0000976)3.10034222
31Increased connective tissue (HP:0009025)3.04604383
32Abnormality of nail color (HP:0100643)3.01452511
33Urticaria (HP:0001025)3.00484942
34Palmoplantar keratoderma (HP:0000982)2.99045750
35Abnormal blistering of the skin (HP:0008066)2.96127220
36Round ear (HP:0100830)2.88840616
37Ventricular tachycardia (HP:0004756)2.87985792
38Hamartoma of the eye (HP:0010568)2.87659679
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.76408674
40Muscle fiber inclusion bodies (HP:0100299)2.76314158
41Thick nail (HP:0001805)2.73879866
42Abnormality of the gastric mucosa (HP:0004295)2.70523096
43Exercise-induced myalgia (HP:0003738)2.68459333
44Abnormality of the axillary hair (HP:0100134)2.67170057
45Abnormality of secondary sexual hair (HP:0009888)2.67170057
46Furrowed tongue (HP:0000221)2.64184928
47Fragile nails (HP:0001808)2.61774477
48Distal arthrogryposis (HP:0005684)2.58026985
49Pustule (HP:0200039)2.55819230
50Acanthosis nigricans (HP:0000956)2.54803030
51Amniotic constriction ring (HP:0009775)2.54332766
52Abnormality of placental membranes (HP:0011409)2.54332766
53Type I diabetes mellitus (HP:0100651)2.54105086
54Distal lower limb muscle weakness (HP:0009053)2.48323511
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.48060397
56Unilateral renal agenesis (HP:0000122)2.46943558
57Dry skin (HP:0000958)2.46042010
58Abnormal hair laboratory examination (HP:0003328)2.45496692
59Natal tooth (HP:0000695)2.41091057
60Sparse scalp hair (HP:0002209)2.40093547
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.38350624
62Nemaline bodies (HP:0003798)2.36581835
63Sparse eyelashes (HP:0000653)2.35677772
64Dehydration (HP:0001944)2.35615796
65Double outlet right ventricle (HP:0001719)2.35441395
66Congenital malformation of the right heart (HP:0011723)2.35441395
67Intention tremor (HP:0002080)2.34168686
68Hypoparathyroidism (HP:0000829)2.31028700
69Myopathic facies (HP:0002058)2.30420077
70Laryngomalacia (HP:0001601)2.29080134
71Abnormality of the phalanges of the 5th finger (HP:0004213)2.24712526
72Fasciculations (HP:0002380)2.22047408
73Autoamputation (HP:0001218)2.21321250
74Ectropion (HP:0000656)2.21306320
75Type 1 muscle fiber predominance (HP:0003803)2.21096056
76Milia (HP:0001056)2.19808004
77Neonatal death (HP:0003811)2.17686984
78Pili torti (HP:0003777)2.13750154
79Absent phalangeal crease (HP:0006109)2.12993423
80Areflexia of lower limbs (HP:0002522)2.11791137
81Slow-growing hair (HP:0002217)2.10737951
82Abnormality of hair growth rate (HP:0011363)2.10737951
83Abnormality of the labia majora (HP:0012881)2.09647427
84Autoimmune thrombocytopenia (HP:0001973)2.05949724
85Difficulty running (HP:0009046)2.05192936
86Melanocytic nevus (HP:0000995)2.03260079
87Ridged nail (HP:0001807)2.02159149
88Calf muscle hypertrophy (HP:0008981)1.99698279
89Dysdiadochokinesis (HP:0002075)1.98395673
90Lack of skin elasticity (HP:0100679)1.98350418
91Ulnar deviation of the wrist (HP:0003049)1.97565576
92Multifactorial inheritance (HP:0001426)1.96826203
93Hyperhidrosis (HP:0000975)1.96770232
94Selective tooth agenesis (HP:0001592)1.96768036
95Muscle hypertrophy of the lower extremities (HP:0008968)1.96385792
96Interstitial pulmonary disease (HP:0006530)1.94838142
97Sepsis (HP:0100806)1.94828346
98Brittle hair (HP:0002299)1.94409099
99Nail dystrophy (HP:0008404)1.94280091
100Asthma (HP:0002099)1.93795412
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91901013
102Keratoconjunctivitis (HP:0001096)1.89188520
103Autoimmune hemolytic anemia (HP:0001890)1.89179726
104Anonychia (HP:0001798)1.88589055
105Aplasia involving bones of the extremities (HP:0009825)1.87691006
106Aplasia involving bones of the upper limbs (HP:0009823)1.87691006
107Aplasia of the phalanges of the hand (HP:0009802)1.87691006
108Popliteal pterygium (HP:0009756)1.87683643
109Axonal loss (HP:0003447)1.87600908
110Ventricular fibrillation (HP:0001663)1.87004164
111Villous atrophy (HP:0011473)1.85891521
112Abnormality of small intestinal villus morphology (HP:0011472)1.85891521
113Intellectual disability, profound (HP:0002187)1.83979595
114Calcaneovalgus deformity (HP:0001848)1.82953363
115Advanced eruption of teeth (HP:0006288)1.82832378
116Hypoplastic labia majora (HP:0000059)1.82043831
117Synostosis involving the elbow (HP:0003938)1.81461840
118Humeroradial synostosis (HP:0003041)1.81461840
119Muscle stiffness (HP:0003552)1.81041855
120Blepharitis (HP:0000498)1.79192730
121Split foot (HP:0001839)1.77920689
122Abnormality of the neuromuscular junction (HP:0003398)1.77566264
123Fatigable weakness (HP:0003473)1.77566264
124Recurrent corneal erosions (HP:0000495)1.75208008
125Cholelithiasis (HP:0001081)1.71291190
126Paralysis (HP:0003470)1.70844590
127Abnormal finger flexion creases (HP:0006143)1.70077096
128Duplicated collecting system (HP:0000081)1.68727986
129Depressed nasal tip (HP:0000437)1.65020709
130Skin ulcer (HP:0200042)1.64723709
131Segmental peripheral demyelination/remyelination (HP:0003481)1.64164509
132Xerostomia (HP:0000217)1.62737074
133Carious teeth (HP:0000670)1.58471533
134Hamartoma (HP:0010566)1.56602146
135Septate vagina (HP:0001153)1.54600130
136Fine hair (HP:0002213)1.54247293
137Corneal dystrophy (HP:0001131)1.54172294
138Conical tooth (HP:0000698)1.48970293
139Nasolacrimal duct obstruction (HP:0000579)1.46581414
140Abnormality of the dental root (HP:0006486)1.44901886
141Taurodontia (HP:0000679)1.44901886
142Abnormality of permanent molar morphology (HP:0011071)1.44901886
143Abnormal auditory evoked potentials (HP:0006958)1.44633395
144Keratoconjunctivitis sicca (HP:0001097)1.43574638
145Abnormality of the fingernails (HP:0001231)1.42431654
146Abnormality of the renal collecting system (HP:0004742)1.42111854
147Verrucae (HP:0200043)1.41766387
148Papilloma (HP:0012740)1.41766387
149Anhidrosis (HP:0000970)1.37654485
150Abnormality of molar morphology (HP:0011070)1.37407816
151Abnormality of molar (HP:0011077)1.37407816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.20122647
2TGFBR15.89465715
3CDK124.51825947
4FGFR14.09200965
5LATS13.89852800
6TTN3.87649709
7SGK2233.15921991
8SGK4943.15921991
9ERBB32.73960229
10FER2.66931573
11TRPM72.66637180
12DYRK1B2.38909394
13BCR2.38739628
14DYRK32.21624402
15ERN12.17647299
16MAP3K142.08548359
17MAPKAPK32.07472465
18MST41.97108961
19MET1.95062800
20NEK91.92298315
21EPHA21.90017536
22LRRK21.86735564
23MAP3K91.82524136
24MAP3K31.81404114
25MUSK1.80722892
26STK101.74932102
27LATS21.70725805
28EPHA31.65736277
29PIK3CG1.61459576
30ERBB41.61266195
31MAP3K61.59970879
32KSR21.55862048
33TESK11.51097670
34TAOK31.37382634
35TAOK11.34951768
36TIE11.33111787
37OBSCN1.25013627
38BMPR21.23107782
39GRK11.21934107
40LIMK11.17451836
41IRAK11.16327449
42MAPKAPK51.15618698
43RPS6KB21.13506377
44GSK3A1.08457571
45RIPK41.05411808
46PAK31.05321494
47GRK61.04492415
48MAPK71.02398748
49TYK21.02253834
50SGK20.99022700
51WNK10.94580374
52CAMK1D0.94160320
53STK240.93474939
54EEF2K0.91353279
55EPHB10.91140274
56IKBKB0.90396252
57FGFR20.89315952
58SGK10.85370743
59RPS6KB10.85356502
60SGK30.82695800
61DMPK0.80256261
62PIK3CA0.78654012
63FGFR40.78009143
64STK38L0.77829445
65PRPF4B0.77138104
66PBK0.76387883
67MAPK120.75076782
68PINK10.73656479
69BRAF0.73102448
70RIPK10.73080915
71MOS0.70320942
72BMX0.67827617
73TRIB30.66503807
74MAP3K130.64668908
75NTRK10.64246502
76TNK20.62300817
77PRKAA20.60003568
78PAK60.59525642
79PIM20.59367982
80STK380.58916737
81RAF10.58913125
82KIT0.58467784
83MAPK110.58178939
84PRKD20.56079847
85MAP3K100.55552900
86PDGFRB0.55392175
87CAMK1G0.55073226
88EPHB20.54913570
89RET0.54698904
90PRKD10.52627220
91PDGFRA0.51318055
92AKT30.51310261
93BRD40.50272786
94JAK20.48925315
95ITK0.47739548
96EPHA40.47675783
97NTRK20.47636033
98MTOR0.47011700
99FGFR30.46789200
100PTK20.46458215
101ADRBK10.46133426
102PKN10.46029806
103TYRO30.45530726
104PHKG20.45107049
105PHKG10.45107049
106JAK30.44322524
107HIPK20.43554204
108CDK60.42717784
109MAP3K20.40323195
110KSR10.40220406
111TGFBR20.39817120
112IKBKE0.39431411
113MAP2K60.39150859
114HCK0.38712876
115MARK20.38311553
116MAP3K10.38177255
117MAP3K70.37107480
118MAP2K10.35600089
119PRKCQ0.35449491
120ROCK20.35190001
121CDK70.34839269
122DYRK1A0.34747200
123ICK0.33142545
124ABL10.32133669
125ROCK10.31239060
126MARK30.29952814
127STK30.29308603
128MAPKAPK20.29187799
129TTK0.28860222
130NLK0.28782593
131PRKCE0.27656606
132FGR0.27568621
133BMPR1B0.27548447
134MINK10.27192981
135PDPK10.27150327
136CDC42BPA0.25877004
137SYK0.24679086
138FLT30.24657233
139ILK0.24501361
140MAPK90.24093591
141ABL20.23464357
142PRKCD0.22192604
143PTK60.22176599
144MAP3K120.21584473
145PAK20.16266053
146CSNK1E0.14868696
147RPS6KA20.14206933

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.61222517
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.49548666
3Histidine metabolism_Homo sapiens_hsa003403.76996577
4Fatty acid elongation_Homo sapiens_hsa000623.50990984
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.33421148
6Phenylalanine metabolism_Homo sapiens_hsa003603.18730086
7Sphingolipid metabolism_Homo sapiens_hsa006002.52758430
8Linoleic acid metabolism_Homo sapiens_hsa005912.45939968
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42947185
10Caffeine metabolism_Homo sapiens_hsa002322.33530074
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15844133
12Arachidonic acid metabolism_Homo sapiens_hsa005902.08697451
13Circadian rhythm_Homo sapiens_hsa047101.91971480
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86795419
15Fat digestion and absorption_Homo sapiens_hsa049751.71627461
16Salivary secretion_Homo sapiens_hsa049701.70452161
17Tyrosine metabolism_Homo sapiens_hsa003501.64810623
18Fatty acid biosynthesis_Homo sapiens_hsa000611.59768696
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59372132
20Retinol metabolism_Homo sapiens_hsa008301.51124219
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48747224
22Ether lipid metabolism_Homo sapiens_hsa005651.47423778
23Chemical carcinogenesis_Homo sapiens_hsa052041.47215100
24beta-Alanine metabolism_Homo sapiens_hsa004101.29598629
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28018610
26Adherens junction_Homo sapiens_hsa045201.13732671
27Arginine biosynthesis_Homo sapiens_hsa002201.08981064
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.01135493
29p53 signaling pathway_Homo sapiens_hsa041150.99256351
30Fatty acid degradation_Homo sapiens_hsa000710.98037871
31Glycerolipid metabolism_Homo sapiens_hsa005610.96019154
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94923393
33Tight junction_Homo sapiens_hsa045300.94064394
34Platelet activation_Homo sapiens_hsa046110.93217568
35Acute myeloid leukemia_Homo sapiens_hsa052210.92556745
36Phototransduction_Homo sapiens_hsa047440.89608353
37Oxytocin signaling pathway_Homo sapiens_hsa049210.87965481
38VEGF signaling pathway_Homo sapiens_hsa043700.87820746
39Long-term potentiation_Homo sapiens_hsa047200.87330227
40Glutathione metabolism_Homo sapiens_hsa004800.86849510
41Sphingolipid signaling pathway_Homo sapiens_hsa040710.86606096
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84726784
43Staphylococcus aureus infection_Homo sapiens_hsa051500.82968883
44Ribosome_Homo sapiens_hsa030100.80576424
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79930481
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78748068
47Serotonergic synapse_Homo sapiens_hsa047260.77205628
48Estrogen signaling pathway_Homo sapiens_hsa049150.76941850
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.75537218
50GnRH signaling pathway_Homo sapiens_hsa049120.75157130
51Fatty acid metabolism_Homo sapiens_hsa012120.74919726
52MicroRNAs in cancer_Homo sapiens_hsa052060.73330243
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.70611131
54Ras signaling pathway_Homo sapiens_hsa040140.67940570
55Thyroid cancer_Homo sapiens_hsa052160.64605018
56TGF-beta signaling pathway_Homo sapiens_hsa043500.63357020
57Ovarian steroidogenesis_Homo sapiens_hsa049130.63314914
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62798187
59Glutamatergic synapse_Homo sapiens_hsa047240.62684403
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61585936
61Insulin signaling pathway_Homo sapiens_hsa049100.60549124
62ABC transporters_Homo sapiens_hsa020100.56406647
63HIF-1 signaling pathway_Homo sapiens_hsa040660.52885761
64Glucagon signaling pathway_Homo sapiens_hsa049220.52640700
65Pancreatic secretion_Homo sapiens_hsa049720.52573449
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51648440
67Dorso-ventral axis formation_Homo sapiens_hsa043200.51327404
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51215167
69Renin secretion_Homo sapiens_hsa049240.51015323
70Hippo signaling pathway_Homo sapiens_hsa043900.50588792
71Amoebiasis_Homo sapiens_hsa051460.50393090
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.49721216
73Inositol phosphate metabolism_Homo sapiens_hsa005620.49597408
74ECM-receptor interaction_Homo sapiens_hsa045120.49064086
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48600339
76Olfactory transduction_Homo sapiens_hsa047400.48302595
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.48073145
78MAPK signaling pathway_Homo sapiens_hsa040100.46696091
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46624699
80Calcium signaling pathway_Homo sapiens_hsa040200.46410380
81Circadian entrainment_Homo sapiens_hsa047130.45548047
82Rap1 signaling pathway_Homo sapiens_hsa040150.45283524
83Notch signaling pathway_Homo sapiens_hsa043300.44227880
84Axon guidance_Homo sapiens_hsa043600.44099007
85Amphetamine addiction_Homo sapiens_hsa050310.43871195
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.42923127
87Bladder cancer_Homo sapiens_hsa052190.42346822
88Pertussis_Homo sapiens_hsa051330.41819278
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41594931
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.40665814
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40379884
92Pathways in cancer_Homo sapiens_hsa052000.39635760
93Focal adhesion_Homo sapiens_hsa045100.38922940
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.38901743
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38611152
96ErbB signaling pathway_Homo sapiens_hsa040120.37142812
97Protein digestion and absorption_Homo sapiens_hsa049740.36208681
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36137616
99PPAR signaling pathway_Homo sapiens_hsa033200.35827748
100Dopaminergic synapse_Homo sapiens_hsa047280.35827362
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35134072
102Basal cell carcinoma_Homo sapiens_hsa052170.34483017
103Melanoma_Homo sapiens_hsa052180.34303074
104Pancreatic cancer_Homo sapiens_hsa052120.32133285
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31876375
106cAMP signaling pathway_Homo sapiens_hsa040240.31765431
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.31643008
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31502778
109Toxoplasmosis_Homo sapiens_hsa051450.31308037
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30814359
111Dilated cardiomyopathy_Homo sapiens_hsa054140.30777867
112Nitrogen metabolism_Homo sapiens_hsa009100.30659380
113Hedgehog signaling pathway_Homo sapiens_hsa043400.30598120
114Melanogenesis_Homo sapiens_hsa049160.30439112
115Primary immunodeficiency_Homo sapiens_hsa053400.29935821
116Choline metabolism in cancer_Homo sapiens_hsa052310.28998908
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28838972
118Endocytosis_Homo sapiens_hsa041440.27616837
119Phagosome_Homo sapiens_hsa041450.27570184
120Renal cell carcinoma_Homo sapiens_hsa052110.27000652
121Osteoclast differentiation_Homo sapiens_hsa043800.26803430
122Proteoglycans in cancer_Homo sapiens_hsa052050.26294577
123Leishmaniasis_Homo sapiens_hsa051400.26175855
124Long-term depression_Homo sapiens_hsa047300.25985512
125Gastric acid secretion_Homo sapiens_hsa049710.25397724
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.24346419
127Tuberculosis_Homo sapiens_hsa051520.24301997
128Hepatitis C_Homo sapiens_hsa051600.23485983
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.22853482
130Chemokine signaling pathway_Homo sapiens_hsa040620.20844452
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20583991
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.20430575
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.19464431
134Complement and coagulation cascades_Homo sapiens_hsa046100.18252887
135Malaria_Homo sapiens_hsa051440.17290993
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17253658
137Glioma_Homo sapiens_hsa052140.16929654
138Salmonella infection_Homo sapiens_hsa051320.16368569

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