SERPINA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55514206
2L-phenylalanine catabolic process (GO:0006559)7.55514206
3L-phenylalanine metabolic process (GO:0006558)7.18203206
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18203206
5aromatic amino acid family catabolic process (GO:0009074)6.54490737
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.29256206
7glyoxylate metabolic process (GO:0046487)5.69657948
8regulation of plasminogen activation (GO:0010755)5.67437577
9bile acid biosynthetic process (GO:0006699)5.67178675
10alpha-linolenic acid metabolic process (GO:0036109)5.64671873
11indole-containing compound catabolic process (GO:0042436)5.63093993
12indolalkylamine catabolic process (GO:0046218)5.63093993
13tryptophan catabolic process (GO:0006569)5.63093993
14negative regulation of fibrinolysis (GO:0051918)5.62678921
15complement activation, alternative pathway (GO:0006957)5.58836660
16kynurenine metabolic process (GO:0070189)5.57174684
17high-density lipoprotein particle remodeling (GO:0034375)5.57058868
18regulation of protein activation cascade (GO:2000257)5.56761918
19protein carboxylation (GO:0018214)5.43958599
20peptidyl-glutamic acid carboxylation (GO:0017187)5.43958599
21urea metabolic process (GO:0019627)5.37716945
22urea cycle (GO:0000050)5.37716945
23tryptophan metabolic process (GO:0006568)5.37217737
24regulation of fibrinolysis (GO:0051917)5.36641275
25cysteine metabolic process (GO:0006534)5.26554190
26sulfur amino acid catabolic process (GO:0000098)5.22159993
27epoxygenase P450 pathway (GO:0019373)5.18701134
28regulation of complement activation (GO:0030449)5.16995056
29regulation of apoptotic cell clearance (GO:2000425)5.10810207
30intestinal cholesterol absorption (GO:0030299)5.09583098
31positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.08232737
32regulation of cholesterol esterification (GO:0010872)5.04633570
33reverse cholesterol transport (GO:0043691)5.03409016
34bile acid metabolic process (GO:0008206)4.97049151
35regulation of humoral immune response (GO:0002920)4.94048176
36plasma lipoprotein particle remodeling (GO:0034369)4.93371964
37protein-lipid complex remodeling (GO:0034368)4.93371964
38macromolecular complex remodeling (GO:0034367)4.93371964
39nitrogen cycle metabolic process (GO:0071941)4.92550471
40aromatic amino acid family metabolic process (GO:0009072)4.87730384
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83897074
42negative regulation of hemostasis (GO:1900047)4.80773820
43negative regulation of blood coagulation (GO:0030195)4.80773820
44tyrosine metabolic process (GO:0006570)4.80343694
45regulation of triglyceride catabolic process (GO:0010896)4.75598674
46serine family amino acid catabolic process (GO:0009071)4.74891660
47negative regulation of complement activation (GO:0045916)4.72431829
48homocysteine metabolic process (GO:0050667)4.70153142
49phospholipid efflux (GO:0033700)4.69197490
50acylglycerol homeostasis (GO:0055090)4.64866068
51triglyceride homeostasis (GO:0070328)4.64866068
52drug catabolic process (GO:0042737)4.52738273
53positive regulation of hemostasis (GO:1900048)4.44756573
54positive regulation of blood coagulation (GO:0030194)4.44756573
55alpha-amino acid catabolic process (GO:1901606)4.41984257
56bile acid and bile salt transport (GO:0015721)4.41901303
57negative regulation of coagulation (GO:0050819)4.40074150
58cholesterol efflux (GO:0033344)4.39496649
59amino-acid betaine metabolic process (GO:0006577)4.39184502
60lysine catabolic process (GO:0006554)4.36380511
61lysine metabolic process (GO:0006553)4.36380511
62negative regulation of sterol transport (GO:0032372)4.35756092
63negative regulation of cholesterol transport (GO:0032375)4.35756092
64plasma lipoprotein particle clearance (GO:0034381)4.33938286
65indolalkylamine metabolic process (GO:0006586)4.33528766
66negative regulation of wound healing (GO:0061045)4.31848819
67cellular ketone body metabolic process (GO:0046950)4.30357727
68omega-hydroxylase P450 pathway (GO:0097267)4.28209057
69coenzyme catabolic process (GO:0009109)4.23730154
70low-density lipoprotein particle remodeling (GO:0034374)4.19064419
71exogenous drug catabolic process (GO:0042738)4.15201354
72glutamate metabolic process (GO:0006536)4.11894563
73plasma lipoprotein particle assembly (GO:0034377)4.10764343
74positive regulation of coagulation (GO:0050820)4.08994533
75uronic acid metabolic process (GO:0006063)4.08538607
76glucuronate metabolic process (GO:0019585)4.08538607
77cellular amino acid catabolic process (GO:0009063)4.08494904
78fibrinolysis (GO:0042730)4.07879715
79glycine metabolic process (GO:0006544)4.04964550
80imidazole-containing compound metabolic process (GO:0052803)4.01710220
81dicarboxylic acid biosynthetic process (GO:0043650)3.99044107
82ethanol metabolic process (GO:0006067)3.98825912
83phospholipid homeostasis (GO:0055091)3.92385453
84cellular glucuronidation (GO:0052695)3.92296001
85cellular modified amino acid catabolic process (GO:0042219)3.91610679
86serine family amino acid metabolic process (GO:0009069)3.86433770
87aldehyde catabolic process (GO:0046185)3.85781745
88positive regulation of fatty acid biosynthetic process (GO:0045723)3.84029516
89amine catabolic process (GO:0009310)3.81822192
90cellular biogenic amine catabolic process (GO:0042402)3.81822192
91benzene-containing compound metabolic process (GO:0042537)3.80743475
92complement activation, classical pathway (GO:0006958)3.79465536
93positive regulation of lipid catabolic process (GO:0050996)3.78269836
94plasma lipoprotein particle organization (GO:0071827)3.77905067
95very-low-density lipoprotein particle assembly (GO:0034379)3.76579604
96negative regulation of lipase activity (GO:0060192)3.76268428
97blood coagulation, intrinsic pathway (GO:0007597)3.74371384
98cytolysis (GO:0019835)3.73797481
99proline metabolic process (GO:0006560)3.73233436
100acute-phase response (GO:0006953)3.72226863
101complement activation (GO:0006956)3.71739327
102ketone body metabolic process (GO:1902224)3.70818280
103negative regulation of protein activation cascade (GO:2000258)3.70014948
104protein activation cascade (GO:0072376)3.69519919
105protein-lipid complex assembly (GO:0065005)3.69367078
106negative regulation of humoral immune response (GO:0002921)3.68754734
107ethanol oxidation (GO:0006069)3.68652000
108positive regulation of extracellular matrix organization (GO:1903055)3.68130393
109cholesterol homeostasis (GO:0042632)3.67677085
110opsonization (GO:0008228)3.65872795
111positive regulation of lipoprotein lipase activity (GO:0051006)3.65830298
112positive regulation of triglyceride lipase activity (GO:0061365)3.65830298
113drug metabolic process (GO:0017144)3.65682103
114serine family amino acid biosynthetic process (GO:0009070)3.65197909
115arginine metabolic process (GO:0006525)3.65059300
116cofactor catabolic process (GO:0051187)3.64635791
117lipoprotein metabolic process (GO:0042157)3.63389961
118sterol homeostasis (GO:0055092)3.61747787
119drug transmembrane transport (GO:0006855)3.60317207
120regulation of bile acid biosynthetic process (GO:0070857)3.60112168
121carboxylic acid catabolic process (GO:0046395)3.59672540
122organic acid catabolic process (GO:0016054)3.59672540
123acute inflammatory response (GO:0002526)3.58537005
124regulation of cholesterol homeostasis (GO:2000188)3.56929843
125protein-lipid complex subunit organization (GO:0071825)3.55987899
126cholesterol transport (GO:0030301)3.54852533
127sterol transport (GO:0015918)3.54852533
128short-chain fatty acid metabolic process (GO:0046459)3.52241064
129regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.47902596
130phenylpropanoid metabolic process (GO:0009698)3.42515988
131intestinal absorption (GO:0050892)3.39190564
132diacylglycerol metabolic process (GO:0046339)3.38706152
133regulation of acute inflammatory response (GO:0002673)3.32867969
134peptidyl-glutamic acid modification (GO:0018200)3.26542382
135regulation of cholesterol biosynthetic process (GO:0045540)3.22540344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.11209316
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.90919429
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.60053030
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.36270324
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.08760695
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05563899
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33291781
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05761685
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97615038
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09760391
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07426761
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6515532
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98770477
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98732075
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98495601
16CLOCK_20551151_ChIP-Seq_293T_Human1.89890502
17GATA1_22025678_ChIP-Seq_K562_Human1.83405529
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.75165580
19HTT_18923047_ChIP-ChIP_STHdh_Human1.69793571
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.55296038
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44672638
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42403765
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41050691
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25332974
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25170964
26AR_21909140_ChIP-Seq_LNCAP_Human1.23318611
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16777907
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.16104275
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15598798
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07810871
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04463521
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04337828
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00750348
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00312958
35HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96459061
36NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93653713
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93653713
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92416788
39IRF8_22096565_ChIP-ChIP_GC-B_Human0.90927726
40CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90215875
41GATA4_25053715_ChIP-Seq_YYC3_Human0.89296547
42SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88358204
43PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87062370
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83258376
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83236190
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82256785
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80574692
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77487005
49FOXA1_25552417_ChIP-Seq_VCAP_Human0.76799592
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73671544
51NFE2_27457419_Chip-Seq_LIVER_Mouse0.73573207
52SMAD1_18555785_Chip-Seq_ESCs_Mouse0.73108078
53POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72768594
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70445628
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70173312
56LXR_22292898_ChIP-Seq_THP-1_Human0.69118911
57AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67617086
58CTNNB1_20460455_ChIP-Seq_HCT116_Human0.67126518
59STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.66404935
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65382500
61FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64678818
62TAF15_26573619_Chip-Seq_HEK293_Human0.64020236
63ESRRB_18555785_Chip-Seq_ESCs_Mouse0.63937913
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63429058
65RUNX1_27457419_Chip-Seq_LIVER_Mouse0.62702423
66SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62612046
67RARA_24833708_ChIP-Seq_LIVER_Mouse0.62468568
68RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61532480
69SUZ12_27294783_Chip-Seq_NPCs_Mouse0.61449200
70AR_20517297_ChIP-Seq_VCAP_Human0.61038636
71KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60927109
72ZFX_18555785_Chip-Seq_ESCs_Mouse0.59806090
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.59793870
74OCT4_18555785_Chip-Seq_ESCs_Mouse0.59569769
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58963258
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58655268
77AR_21572438_ChIP-Seq_LNCaP_Human0.58566971
78TP53_16413492_ChIP-PET_HCT116_Human0.58545263
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58250271
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58145211
81CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57526750
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.57229406
83SOX2_20726797_ChIP-Seq_SW620_Human0.56877314
84ZNF263_19887448_ChIP-Seq_K562_Human0.56770208
85ERG_20517297_ChIP-Seq_VCAP_Human0.56197415
86NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.55716851
87BCAT_22108803_ChIP-Seq_LS180_Human0.55187369
88KLF4_18555785_Chip-Seq_ESCs_Mouse0.55021246
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.54888495
90SOX2_21211035_ChIP-Seq_LN229_Human0.54637978
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54479605
92RAC3_21632823_ChIP-Seq_H3396_Human0.54393946
93SOX11_22085726_ChIP-Seq_ESNs_Mouse0.53550080
94CBP_21632823_ChIP-Seq_H3396_Human0.53543842
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53370260
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.53361089
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.52958097
98EGR1_19032775_ChIP-ChIP_M12_Human0.52664941
99GATA1_19941826_ChIP-Seq_K562_Human0.52305924
100PU1_27457419_Chip-Seq_LIVER_Mouse0.52190812
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.51808869
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.51716771
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.51469460
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51370477
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.51366805
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51243899
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.51111477
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.50883327
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.50014132
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49619704
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.49408847
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49187421
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.48858709
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.48718408
115CDX2_22108803_ChIP-Seq_LS180_Human0.48239904
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.47396896
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.47331470
118MYC_19915707_ChIP-ChIP_AK7_Human0.47328483
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.46782117
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.46653802
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.45693782
122GATA2_19941826_ChIP-Seq_K562_Human0.45686104
123CEBPB_22108803_ChIP-Seq_LS180_Human0.43321845
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.42965514
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42835877
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42622194
127ESET_19884257_ChIP-Seq_ESCs_Mouse0.42600947
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42446104
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.42149158
130GATA6_25053715_ChIP-Seq_YYC3_Human0.41962767
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.41701491
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.41337618
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41133096
134STAT1_17558387_ChIP-Seq_HELA_Human0.41085645
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.41001018
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40894844
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.40043199
138FOXM1_26456572_ChIP-Seq_MCF-7_Human0.39784381
139TRIM28_21343339_ChIP-Seq_HEK293_Human0.39591876
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39045266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.95893804
2MP0005360_urolithiasis7.10866852
3MP0005085_abnormal_gallbladder_physiolo6.46173889
4MP0005365_abnormal_bile_salt6.31582702
5MP0008875_abnormal_xenobiotic_pharmacok4.73876588
6MP0003252_abnormal_bile_duct4.22997994
7MP0003806_abnormal_nucleotide_metabolis3.91190151
8MP0010329_abnormal_lipoprotein_level3.55200791
9MP0003122_maternal_imprinting3.21101272
10MP0003195_calcinosis3.07051913
11MP0009840_abnormal_foam_cell3.05995642
12MP0005083_abnormal_biliary_tract2.98575517
13MP0005332_abnormal_amino_acid2.71820601
14MP0001666_abnormal_nutrient_absorption2.61266342
15MP0003191_abnormal_cellular_cholesterol2.40673991
16MP0002138_abnormal_hepatobiliary_system2.16721477
17MP0000609_abnormal_liver_physiology2.16128884
18MP0004019_abnormal_vitamin_homeostasis2.11393645
19MP0002118_abnormal_lipid_homeostasis2.09861777
20MP0003868_abnormal_feces_composition2.09034324
21MP0001915_intracranial_hemorrhage1.81738393
22MP0005319_abnormal_enzyme/_coenzyme1.78120990
23MP0001764_abnormal_homeostasis1.68070792
24MP0002132_abnormal_respiratory_system1.66352543
25MP0003123_paternal_imprinting1.58726819
26MP0002089_abnormal_postnatal_growth/wei1.52255120
27MP0005584_abnormal_enzyme/coenzyme_acti1.46523938
28MP0002909_abnormal_adrenal_gland1.40300138
29MP0009697_abnormal_copulation1.37833190
30MP0009643_abnormal_urine_homeostasis1.37824395
31MP0002254_reproductive_system_inflammat1.29301769
32MP0000566_synostosis1.28767085
33MP0002837_dystrophic_cardiac_calcinosis1.23228223
34MP0004272_abnormal_basement_membrane1.20496851
35MP0003172_abnormal_lysosome_physiology1.19492206
36MP0003656_abnormal_erythrocyte_physiolo1.19358346
37MP0000604_amyloidosis1.17514586
38MP0000598_abnormal_liver_morphology1.15962653
39MP0003186_abnormal_redox_activity1.11264134
40MP0003011_delayed_dark_adaptation1.10572691
41MP0005451_abnormal_body_composition1.10492262
42MP0002078_abnormal_glucose_homeostasis1.10070581
43MP0005636_abnormal_mineral_homeostasis1.06951700
44MP0005220_abnormal_exocrine_pancreas1.04614734
45MP0009763_increased_sensitivity_to1.02629986
46MP0003705_abnormal_hypodermis_morpholog0.98031175
47MP0000639_abnormal_adrenal_gland0.97264281
48MP0002876_abnormal_thyroid_physiology0.95956543
49MP0005409_darkened_coat_color0.93663929
50MP0009764_decreased_sensitivity_to0.91607696
51MP0005647_abnormal_sex_gland0.91281330
52MP0009642_abnormal_blood_homeostasis0.90992729
53MP0005408_hypopigmentation0.90367353
54MP0005670_abnormal_white_adipose0.89599794
55MP0008469_abnormal_protein_level0.88431637
56MP0003121_genomic_imprinting0.86548386
57MP0005084_abnormal_gallbladder_morpholo0.85824541
58MP0001756_abnormal_urination0.84327301
59MP0004130_abnormal_muscle_cell0.81138445
60MP0006054_spinal_hemorrhage0.80885686
61MP0005376_homeostasis/metabolism_phenot0.80487799
62MP0005535_abnormal_body_temperature0.80299692
63MP0003941_abnormal_skin_development0.79538308
64MP0006036_abnormal_mitochondrial_physio0.79083567
65MP0009765_abnormal_xenobiotic_induced0.78405185
66MP0010368_abnormal_lymphatic_system0.77609448
67MP0005167_abnormal_blood-brain_barrier0.76540902
68MP0005334_abnormal_fat_pad0.75194692
69MP0003690_abnormal_glial_cell0.71075486
70MP0001661_extended_life_span0.70055959
71MP0002971_abnormal_brown_adipose0.69964428
72MP0005448_abnormal_energy_balance0.67281037
73MP0005257_abnormal_intraocular_pressure0.66244939
74MP0003183_abnormal_peptide_metabolism0.65846115
75MP0010234_abnormal_vibrissa_follicle0.63722899
76MP0005266_abnormal_metabolism0.62093998
77MP0003950_abnormal_plasma_membrane0.61876154
78MP0002928_abnormal_bile_duct0.61833032
79MP0001944_abnormal_pancreas_morphology0.61002507
80MP0003879_abnormal_hair_cell0.60907589
81MP0003329_amyloid_beta_deposits0.60710128
82MP0003953_abnormal_hormone_level0.59480826
83MP0002282_abnormal_trachea_morphology0.58682671
84MP0005379_endocrine/exocrine_gland_phen0.56922244
85MP0004264_abnormal_extraembryonic_tissu0.55492591
86MP0003567_abnormal_fetal_cardiomyocyte0.54263621
87MP0003632_abnormal_nervous_system0.53542571
88MP0000013_abnormal_adipose_tissue0.53237951
89MP0003724_increased_susceptibility_to0.53139892
90MP0003300_gastrointestinal_ulcer0.52658389
91MP0009384_cardiac_valve_regurgitation0.52203718
92MP0002933_joint_inflammation0.50440531
93MP0000920_abnormal_myelination0.50431796
94MP0005464_abnormal_platelet_physiology0.48888226
95MP0005187_abnormal_penis_morphology0.48435873
96MP0002938_white_spotting0.48366394
97MP0001324_abnormal_eye_pigmentation0.48140996
98MP0002136_abnormal_kidney_physiology0.48121947
99MP0009053_abnormal_anal_canal0.47587621
100MP0006035_abnormal_mitochondrial_morpho0.47234502
101MP0002693_abnormal_pancreas_physiology0.47191120
102MP0005058_abnormal_lysosome_morphology0.46286674
103MP0005395_other_phenotype0.45782582
104MP0005248_abnormal_Harderian_gland0.45686321
105MP0004782_abnormal_surfactant_physiolog0.45661274
106MP0004883_abnormal_blood_vessel0.45123987
107MP0008873_increased_physiological_sensi0.45105300
108MP0005023_abnormal_wound_healing0.44913775
109MP0003638_abnormal_response/metabolism_0.44770812
110MP0005666_abnormal_adipose_tissue0.44322175
111MP0001765_abnormal_ion_homeostasis0.44157504
112MP0009115_abnormal_fat_cell0.43002403
113MP0001270_distended_abdomen0.42842445
114MP0005410_abnormal_fertilization0.42286680
115MP0002168_other_aberrant_phenotype0.42280082
116MP0003315_abnormal_perineum_morphology0.41716146
117MP0000230_abnormal_systemic_arterial0.41202836
118MP0003566_abnormal_cell_adhesion0.38514909
119MP0002697_abnormal_eye_size0.37675309
120MP0000249_abnormal_blood_vessel0.37374021
121MP0003115_abnormal_respiratory_system0.35872891
122MP0004043_abnormal_pH_regulation0.35178340
123MP0003631_nervous_system_phenotype0.34627749
124MP0009780_abnormal_chondrocyte_physiolo0.34574807
125MP0003075_altered_response_to0.34499969
126MP0003943_abnormal_hepatobiliary_system0.33797100
127MP0002128_abnormal_blood_circulation0.33623450
128MP0000427_abnormal_hair_cycle0.31920789
129MP0008874_decreased_physiological_sensi0.31763959
130MP0009672_abnormal_birth_weight0.31759707
131MP0003436_decreased_susceptibility_to0.30434774
132MP0002295_abnormal_pulmonary_circulatio0.29194431
133MP0002970_abnormal_white_adipose0.28752880
134MP0000579_abnormal_nail_morphology0.28521158
135MP0002796_impaired_skin_barrier0.28035029
136MP0002090_abnormal_vision0.27902906
137MP0001845_abnormal_inflammatory_respons0.26944583
138MP0005164_abnormal_response_to0.26821871
139MP0005452_abnormal_adipose_tissue0.25253738

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.42510682
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.24276565
3Deep venous thrombosis (HP:0002625)7.11895297
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57967725
5Prolonged partial thromboplastin time (HP:0003645)6.40180058
6Hypobetalipoproteinemia (HP:0003563)6.27259855
7Xanthomatosis (HP:0000991)6.11922438
8Complement deficiency (HP:0004431)5.60071219
9Hyperlipoproteinemia (HP:0010980)5.23816603
10Abnormality of the common coagulation pathway (HP:0010990)5.16401995
11Hypolipoproteinemia (HP:0010981)4.78808222
12Joint hemorrhage (HP:0005261)4.55380385
13Epidermoid cyst (HP:0200040)4.52593968
14Conjugated hyperbilirubinemia (HP:0002908)4.40070654
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35089431
16Abnormality of the intrinsic pathway (HP:0010989)4.28761526
17Hypoglycemic coma (HP:0001325)4.28251120
18Ketosis (HP:0001946)4.25449919
19Hypoalphalipoproteinemia (HP:0003233)4.25416821
20Hyperammonemia (HP:0001987)4.23822822
21Fat malabsorption (HP:0002630)4.16945094
22Abnormality of methionine metabolism (HP:0010901)4.13043669
23Abnormality of complement system (HP:0005339)4.04043197
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.02462760
25Hyperglycinemia (HP:0002154)4.02359413
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95439372
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85871011
28Hyperglycinuria (HP:0003108)3.65344002
29Abnormality of glycine metabolism (HP:0010895)3.58517459
30Abnormality of serine family amino acid metabolism (HP:0010894)3.58517459
31Hyperbilirubinemia (HP:0002904)3.51684362
32Ketoacidosis (HP:0001993)3.41741059
33Hypercholesterolemia (HP:0003124)3.39184086
34Spontaneous abortion (HP:0005268)3.37378625
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27727482
36Abnormality of pyrimidine metabolism (HP:0004353)3.20507854
37Abnormality of fatty-acid metabolism (HP:0004359)3.17161014
38Nephritis (HP:0000123)3.11990489
39Skin nodule (HP:0200036)3.08803139
40Osteomalacia (HP:0002749)3.07798008
41Hypochromic microcytic anemia (HP:0004840)3.00143212
42Hypoglycemic seizures (HP:0002173)2.97521377
43Purpura (HP:0000979)2.95481701
44Hepatocellular carcinoma (HP:0001402)2.87614955
45Delayed CNS myelination (HP:0002188)2.86346337
46Arthropathy (HP:0003040)2.82640444
47Steatorrhea (HP:0002570)2.79095776
48Abnormality of nucleobase metabolism (HP:0010932)2.77668577
49Abnormality of carpal bone ossification (HP:0006257)2.77667529
50Acanthocytosis (HP:0001927)2.77446331
51Myocardial infarction (HP:0001658)2.76415583
52Abnormality of serum amino acid levels (HP:0003112)2.72667936
53Abnormal tarsal ossification (HP:0008369)2.71537969
54Hyperinsulinemic hypoglycemia (HP:0000825)2.65454105
55Metabolic acidosis (HP:0001942)2.61145395
56Abnormal gallbladder morphology (HP:0012437)2.60093015
57Systemic lupus erythematosus (HP:0002725)2.59381641
58Recurrent gram-negative bacterial infections (HP:0005420)2.58613960
59Abnormality of purine metabolism (HP:0004352)2.56248939
60Gingival bleeding (HP:0000225)2.52577362
61Glomerulonephritis (HP:0000099)2.51335648
62Hyperglycemia (HP:0003074)2.48344721
63Hypophosphatemic rickets (HP:0004912)2.42905213
64Mitral stenosis (HP:0001718)2.42621566
65Lethargy (HP:0001254)2.42446215
66Gout (HP:0001997)2.41287076
67Amyloidosis (HP:0011034)2.39279192
68Spastic diplegia (HP:0001264)2.38852884
69Cholecystitis (HP:0001082)2.38495860
70Abnormal gallbladder physiology (HP:0012438)2.38495860
71Irritability (HP:0000737)2.36730227
72Flat acetabular roof (HP:0003180)2.34727184
73Late onset (HP:0003584)2.34138650
74Cholelithiasis (HP:0001081)2.32534179
75Small epiphyses (HP:0010585)2.29978140
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29295782
77Dicarboxylic aciduria (HP:0003215)2.29295782
78Cerebral edema (HP:0002181)2.28503585
79Broad alveolar ridges (HP:0000187)2.26141304
80Esophageal varix (HP:0002040)2.21848428
81Vascular calcification (HP:0004934)2.21078187
82Pancreatic islet-cell hyperplasia (HP:0004510)2.19454296
83Enlarged kidneys (HP:0000105)2.18867483
84Reduced antithrombin III activity (HP:0001976)2.18772236
85Menorrhagia (HP:0000132)2.18083708
86Pancreatitis (HP:0001733)2.17625183
87Thrombophlebitis (HP:0004418)2.16643809
88Pulmonary embolism (HP:0002204)2.12899320
89Neonatal onset (HP:0003623)2.12752893
90Sensorimotor neuropathy (HP:0007141)2.12198543
91Generalized aminoaciduria (HP:0002909)2.07008586
92Abnormal hand bone ossification (HP:0010660)2.06062055
93Symptomatic seizures (HP:0011145)2.05818795
94Abnormality of the gallbladder (HP:0005264)2.04598734
95Abnormal ossification of hand bones (HP:0005921)2.02414323
96Facial shape deformation (HP:0011334)2.01648550
97Potter facies (HP:0002009)2.01648550
98Abnormality of the Achilles tendon (HP:0005109)2.00587842
99Abnormality of the lumbar spine (HP:0100712)1.99103674
100Increased serum pyruvate (HP:0003542)1.98829023
101Brushfield spots (HP:0001088)1.96490120
102Malnutrition (HP:0004395)1.95909888
103Hepatoblastoma (HP:0002884)1.95448992
104Cardiovascular calcification (HP:0011915)1.95155841
105Renal cortical cysts (HP:0000803)1.93931172
106Peritonitis (HP:0002586)1.93882187
107Abnormal delivery (HP:0001787)1.91703940
108Abnormality of transition element cation homeostasis (HP:0011030)1.91250192
109Abnormality of the nasal septum (HP:0000419)1.91028948
110Poikilocytosis (HP:0004447)1.90815652
111Vomiting (HP:0002013)1.90524229
112Epistaxis (HP:0000421)1.89214169
113Abnormality of vitamin metabolism (HP:0100508)1.88631781
114Abnormality of endocrine pancreas physiology (HP:0012093)1.87754336
115Abnormality of the pancreatic islet cells (HP:0006476)1.87754336
116Broad palm (HP:0001169)1.86630224
117Retinal atrophy (HP:0001105)1.85339213
118Rickets (HP:0002748)1.85153936
119Abnormality of iron homeostasis (HP:0011031)1.83622755
120Joint swelling (HP:0001386)1.82292983
121Proximal tubulopathy (HP:0000114)1.80951292
122Abnormal enzyme/coenzyme activity (HP:0012379)1.80473419
123Opisthotonus (HP:0002179)1.78029571
124Elevated hepatic transaminases (HP:0002910)1.77347166
125Hydroxyprolinuria (HP:0003080)1.76311338
126Abnormality of proline metabolism (HP:0010907)1.76311338
127Hemorrhage of the eye (HP:0011885)1.75460187
128Abnormality of glycolysis (HP:0004366)1.74464446
129Abnormal cartilage morphology (HP:0002763)1.73113467
130Increased serum ferritin (HP:0003281)1.72040148
131Vaginal fistula (HP:0004320)1.71435009
132Abnormal foot bone ossification (HP:0010675)1.69429050
133Hyperphosphaturia (HP:0003109)1.66530952
134Asymmetry of the thorax (HP:0001555)1.64984333
135Epiphyseal dysplasia (HP:0002656)1.64346160
136Fair hair (HP:0002286)1.61985261
137Flared iliac wings (HP:0002869)1.60837963
138Widely patent fontanelles and sutures (HP:0004492)1.60428022
139Urinary glycosaminoglycan excretion (HP:0003541)1.58412439
140Mucopolysacchariduria (HP:0008155)1.58412439
141Diastasis recti (HP:0001540)1.57906294
142Submucous cleft hard palate (HP:0000176)1.57683224
143Abnormality of pain sensation (HP:0010832)1.56538209
144Impaired pain sensation (HP:0007328)1.56538209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.77818603
2TAOK35.29606618
3INSRR4.30278392
4FGFR44.07368270
5ERN13.84948023
6FRK3.53071256
7ICK3.45549044
8SIK13.41397883
9CDK123.05706697
10PIK3CA2.99342116
11TYRO32.84071850
12PIK3CG2.82814061
13ERBB42.68326569
14PKN22.54636566
15FLT32.21341110
16FGFR12.03381441
17MAP2K41.96931034
18MST1R1.92222210
19MAPK151.74874318
20PTK61.63759021
21WNK11.60394434
22TRIB31.58296952
23NEK91.57749012
24MAPK111.49336026
25EPHA31.48021919
26LATS11.45581312
27UHMK11.44647588
28EIF2AK11.44334021
29FGFR21.35389155
30JAK21.31804879
31RIPK11.30609794
32TYK21.28962125
33MAP3K21.25176941
34DAPK21.17838779
35SIK21.15205417
36EPHB11.12103967
37DDR21.07115613
38JAK11.06137265
39ABL20.97333836
40MET0.96427176
41PRKAA20.95881926
42PAK30.93163841
43ERBB20.89855224
44FGFR30.88550701
45FGR0.86985542
46SGK10.86613603
47GSK3A0.82919679
48PRKACG0.82616775
49EEF2K0.82524914
50RPS6KB10.80534596
51NTRK30.78920204
52CSNK1E0.78113651
53MAP3K70.77819278
54CDC42BPA0.77349053
55BCR0.77285897
56CDK70.76180750
57TBK10.73856390
58PRKAA10.73726317
59KDR0.73564446
60RET0.73052413
61EPHA40.73050564
62DYRK1B0.72572055
63SCYL20.70301428
64CAMK2G0.68528154
65NEK10.67444172
66LATS20.67375167
67PINK10.66593060
68MAP3K140.65696380
69CSK0.65436738
70MAP3K30.65309307
71PRKCZ0.65270877
72MAPK40.64828787
73STK390.63236101
74CSNK1D0.61367959
75MAPKAPK30.61296090
76PTK20.59004158
77WNK40.58903157
78MAP3K100.58741427
79CAMK1D0.57696828
80GRK60.56381479
81CDK60.55458254
82SGK30.54816732
83MAP3K50.53121247
84PDK20.51451180
85PDPK10.51441004
86IGF1R0.49387301
87CAMKK10.48247199
88CAMK1G0.48069394
89SRC0.47808439
90NLK0.46452494
91FER0.45548523
92PRKCQ0.45507164
93BRSK10.44497925
94CAMKK20.44235625
95NEK20.43725968
96MAP3K10.43197555
97BRSK20.43165299
98CSNK2A20.42350297
99PDK10.41632623
100KSR20.41623654
101MAP3K130.41176589
102MATK0.40738900
103SGK20.40504481
104HIPK20.40502152
105CSNK2A10.39814812
106CDK40.39744260
107PDGFRA0.39680453
108MAP2K60.39412337
109MAP2K10.39041272
110EPHA20.38227868
111LMTK20.38034419
112CSNK1G10.37966088
113BRD40.36967171
114MAP3K60.36388598
115PRKACB0.36327732
116STK38L0.36025805
117SGK2230.35905963
118SGK4940.35905963
119PRKCG0.35096109
120IRAK30.34870970
121EIF2AK30.34612426
122MAP2K30.34341530
123TIE10.34164610
124PKN10.34025576
125PRKCB0.33789373
126MAPK70.33345981
127CSNK1G20.32515879
128PRKCH0.31854738
129IRAK10.31774800
130MAP3K120.31690250
131EGFR0.30435193
132PDGFRB0.30262886
133PRKCA0.30113932
134MAP3K40.29928651
135MTOR0.29679152
136PRKD10.29432066
137MAPK120.28667735
138PDK40.28531533
139PDK30.28531533
140ITK0.28345823
141NTRK10.26840374
142CSF1R0.25107944
143IKBKE0.25010147
144GRK10.24838640
145RPS6KA30.23864540
146AKT30.23561850
147TGFBR20.23358787
148PRKG10.22160125

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44471720
2Nitrogen metabolism_Homo sapiens_hsa009103.96232071
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44484587
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17643529
5Arginine biosynthesis_Homo sapiens_hsa002202.99949042
6Complement and coagulation cascades_Homo sapiens_hsa046102.91745553
7Tryptophan metabolism_Homo sapiens_hsa003802.70929101
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67685040
9Fatty acid degradation_Homo sapiens_hsa000712.53059733
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51887479
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45066063
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43068571
13Butanoate metabolism_Homo sapiens_hsa006502.17593977
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11457264
15Peroxisome_Homo sapiens_hsa041462.07473559
16Propanoate metabolism_Homo sapiens_hsa006401.92569852
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92261999
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.91329438
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86872109
20Fatty acid metabolism_Homo sapiens_hsa012121.85784583
21PPAR signaling pathway_Homo sapiens_hsa033201.85343068
22Histidine metabolism_Homo sapiens_hsa003401.83092426
23Staphylococcus aureus infection_Homo sapiens_hsa051501.76916512
24Chemical carcinogenesis_Homo sapiens_hsa052041.75196220
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69048788
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.66010494
27beta-Alanine metabolism_Homo sapiens_hsa004101.64923111
28Selenocompound metabolism_Homo sapiens_hsa004501.64841651
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.63452139
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60425825
31Caffeine metabolism_Homo sapiens_hsa002321.60212243
32Phenylalanine metabolism_Homo sapiens_hsa003601.56743620
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53167171
34Sulfur metabolism_Homo sapiens_hsa009201.50583059
35Bile secretion_Homo sapiens_hsa049761.50360391
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49051666
37Retinol metabolism_Homo sapiens_hsa008301.48367653
38Tyrosine metabolism_Homo sapiens_hsa003501.43123419
39Fatty acid elongation_Homo sapiens_hsa000621.34211788
40Pyruvate metabolism_Homo sapiens_hsa006201.30503301
41ABC transporters_Homo sapiens_hsa020101.29792057
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29398248
43Fat digestion and absorption_Homo sapiens_hsa049751.28815441
44Folate biosynthesis_Homo sapiens_hsa007901.26458442
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26158855
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.24151796
47Steroid biosynthesis_Homo sapiens_hsa001001.10142609
48Biosynthesis of amino acids_Homo sapiens_hsa012301.09711256
49Carbon metabolism_Homo sapiens_hsa012001.07393416
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97046941
51Other glycan degradation_Homo sapiens_hsa005110.91749031
52Arginine and proline metabolism_Homo sapiens_hsa003300.89048489
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86578853
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86358318
55Vitamin digestion and absorption_Homo sapiens_hsa049770.83234582
56Lysine degradation_Homo sapiens_hsa003100.80018704
57Vitamin B6 metabolism_Homo sapiens_hsa007500.79871978
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76116795
59Sulfur relay system_Homo sapiens_hsa041220.74550882
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.70082294
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66893489
62Prion diseases_Homo sapiens_hsa050200.66499853
63Glycerolipid metabolism_Homo sapiens_hsa005610.63656184
64One carbon pool by folate_Homo sapiens_hsa006700.59882537
65Pentose phosphate pathway_Homo sapiens_hsa000300.55477658
66Glutathione metabolism_Homo sapiens_hsa004800.55464183
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53104379
68Fatty acid biosynthesis_Homo sapiens_hsa000610.51746462
69Pertussis_Homo sapiens_hsa051330.48746332
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44269139
71N-Glycan biosynthesis_Homo sapiens_hsa005100.44007410
72Metabolic pathways_Homo sapiens_hsa011000.42828100
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36078136
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35277951
75Insulin resistance_Homo sapiens_hsa049310.34744575
76Galactose metabolism_Homo sapiens_hsa000520.28420452
77Linoleic acid metabolism_Homo sapiens_hsa005910.26772877
78Protein export_Homo sapiens_hsa030600.26565878
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.26356209
80Glucagon signaling pathway_Homo sapiens_hsa049220.23518845
81Fructose and mannose metabolism_Homo sapiens_hsa000510.22982554
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.17899686
83Mineral absorption_Homo sapiens_hsa049780.16439804
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14119956
85Sphingolipid metabolism_Homo sapiens_hsa006000.12690417
86ECM-receptor interaction_Homo sapiens_hsa045120.10536945
87Thyroid hormone synthesis_Homo sapiens_hsa049180.07105683
88AMPK signaling pathway_Homo sapiens_hsa041520.06336699
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.05646914
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01395094
91Systemic lupus erythematosus_Homo sapiens_hsa053220.00353239
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1854850
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1843645
94Hepatitis C_Homo sapiens_hsa05160-0.1741995
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1693671
96Ether lipid metabolism_Homo sapiens_hsa00565-0.1693514
97Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1483504
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1248530
99Regulation of autophagy_Homo sapiens_hsa04140-0.1189588
100Protein digestion and absorption_Homo sapiens_hsa04974-0.1141223
101Type II diabetes mellitus_Homo sapiens_hsa04930-0.1127608
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1018557
103Lysosome_Homo sapiens_hsa04142-0.0890131
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0855683
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0726423
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0722956
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0696068
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0378100
109Insulin signaling pathway_Homo sapiens_hsa04910-0.0237285
110African trypanosomiasis_Homo sapiens_hsa05143-0.0118359
111Amoebiasis_Homo sapiens_hsa05146-0.0030490

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