SERPINA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)8.98422283
2hair cycle (GO:0042633)8.64533364
3molting cycle (GO:0042303)8.64533364
4water homeostasis (GO:0030104)8.43828746
5epidermal cell differentiation (GO:0009913)7.33972115
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.11214310
7L-phenylalanine catabolic process (GO:0006559)7.11214310
8L-phenylalanine metabolic process (GO:0006558)6.76809042
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.76809042
10aromatic amino acid family catabolic process (GO:0009074)6.48817781
11intermediate filament organization (GO:0045109)6.40929827
12peptide cross-linking (GO:0018149)6.39627787
13epidermis development (GO:0008544)6.37974587
14indole-containing compound catabolic process (GO:0042436)6.07409807
15indolalkylamine catabolic process (GO:0046218)6.07409807
16tryptophan catabolic process (GO:0006569)6.07409807
17phospholipid efflux (GO:0033700)5.97210035
18kynurenine metabolic process (GO:0070189)5.94128825
19long-chain fatty acid biosynthetic process (GO:0042759)5.90327518
20establishment of skin barrier (GO:0061436)5.87092897
21bile acid biosynthetic process (GO:0006699)5.85964233
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.71705881
23tryptophan metabolic process (GO:0006568)5.66751138
24bundle of His cell to Purkinje myocyte communication (GO:0086069)5.63314655
25high-density lipoprotein particle remodeling (GO:0034375)5.54498780
26glyoxylate metabolic process (GO:0046487)5.50593242
27complement activation, alternative pathway (GO:0006957)5.47773731
28regulation of protein activation cascade (GO:2000257)5.37641992
29urea cycle (GO:0000050)5.35189624
30urea metabolic process (GO:0019627)5.35189624
31negative regulation of fibrinolysis (GO:0051918)5.14367244
32alpha-linolenic acid metabolic process (GO:0036109)5.13876354
33regulation of fibrinolysis (GO:0051917)5.10506102
34regulation of complement activation (GO:0030449)5.09722577
35skin morphogenesis (GO:0043589)5.07010271
36protein carboxylation (GO:0018214)5.05355979
37peptidyl-glutamic acid carboxylation (GO:0017187)5.05355979
38sulfur amino acid catabolic process (GO:0000098)4.97567090
39imidazole-containing compound metabolic process (GO:0052803)4.93741184
40regulation of water loss via skin (GO:0033561)4.93132936
41nitrogen cycle metabolic process (GO:0071941)4.89573869
42regulation of triglyceride catabolic process (GO:0010896)4.83277949
43bile acid metabolic process (GO:0008206)4.79908189
44reverse cholesterol transport (GO:0043691)4.77920727
45positive regulation of cellular amide metabolic process (GO:0034250)4.77307293
46lipoxygenase pathway (GO:0019372)4.73868312
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71485811
48phosphatidylserine acyl-chain remodeling (GO:0036150)4.67431642
49cysteine metabolic process (GO:0006534)4.67128476
50aromatic amino acid family metabolic process (GO:0009072)4.65014646
51plasma lipoprotein particle remodeling (GO:0034369)4.60529211
52protein-lipid complex remodeling (GO:0034368)4.60529211
53macromolecular complex remodeling (GO:0034367)4.60529211
54serine family amino acid catabolic process (GO:0009071)4.60261425
55acylglycerol homeostasis (GO:0055090)4.55154758
56triglyceride homeostasis (GO:0070328)4.55154758
57coenzyme catabolic process (GO:0009109)4.49565955
58phosphatidylinositol acyl-chain remodeling (GO:0036149)4.48606712
59intermediate filament cytoskeleton organization (GO:0045104)4.45717665
60keratinocyte development (GO:0003334)4.35644458
61regulation of cholesterol esterification (GO:0010872)4.34733632
62alpha-amino acid catabolic process (GO:1901606)4.33820987
63amino-acid betaine metabolic process (GO:0006577)4.33048691
64tyrosine metabolic process (GO:0006570)4.32866518
65linoleic acid metabolic process (GO:0043651)4.30788463
66intermediate filament-based process (GO:0045103)4.30300729
67homocysteine metabolic process (GO:0050667)4.27701713
68indolalkylamine metabolic process (GO:0006586)4.24189274
69glutamate metabolic process (GO:0006536)4.22992160
70bile acid and bile salt transport (GO:0015721)4.22290057
71fatty acid elongation (GO:0030497)4.20569998
72lysine catabolic process (GO:0006554)4.18115604
73lysine metabolic process (GO:0006553)4.18115604
74hemidesmosome assembly (GO:0031581)4.15295376
75cytolysis (GO:0019835)4.14748867
76negative regulation of cholesterol transport (GO:0032375)4.14515672
77negative regulation of sterol transport (GO:0032372)4.14515672
78cholesterol efflux (GO:0033344)4.12327084
79fibrinolysis (GO:0042730)4.11201837
80amine catabolic process (GO:0009310)4.11191012
81cellular biogenic amine catabolic process (GO:0042402)4.11191012
82cellular ketone body metabolic process (GO:0046950)4.07588491
83plasma lipoprotein particle clearance (GO:0034381)4.06011930
84glycine metabolic process (GO:0006544)4.05218057
85cellular amino acid catabolic process (GO:0009063)4.00185301
86cellular glucuronidation (GO:0052695)3.93795968
87cellular modified amino acid catabolic process (GO:0042219)3.92338289
88ethanol oxidation (GO:0006069)3.89729733
89benzene-containing compound metabolic process (GO:0042537)3.88925742
90complement activation, classical pathway (GO:0006958)3.84728824
91phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.83755722
92complement activation (GO:0006956)3.78732594
93arginine metabolic process (GO:0006525)3.77341010
94serine family amino acid metabolic process (GO:0009069)3.76895171
95dicarboxylic acid biosynthetic process (GO:0043650)3.74880872
96regulation of cholesterol homeostasis (GO:2000188)3.69040997
97protein activation cascade (GO:0072376)3.68960727
98very long-chain fatty acid metabolic process (GO:0000038)3.67484165
99phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.67477309
100cofactor catabolic process (GO:0051187)3.66502476
101polarized epithelial cell differentiation (GO:0030859)3.65754606
102positive regulation of glomerulus development (GO:0090193)3.65456347
103positive regulation of lipoprotein lipase activity (GO:0051006)3.64078945
104positive regulation of triglyceride lipase activity (GO:0061365)3.64078945
105negative regulation of lipase activity (GO:0060192)3.63003539
106regulation of cell proliferation involved in kidney development (GO:1901722)3.60993649
107blood coagulation, intrinsic pathway (GO:0007597)3.60899997
108regulation of keratinocyte differentiation (GO:0045616)3.60173235
109acetyl-CoA metabolic process (GO:0006084)3.57489413
110plasma lipoprotein particle assembly (GO:0034377)3.56148741
111epithelial cell differentiation involved in prostate gland development (GO:0060742)3.51825792
112aldehyde catabolic process (GO:0046185)3.51819571
113ketone body metabolic process (GO:1902224)3.51048062
114uronic acid metabolic process (GO:0006063)3.50784175
115glucuronate metabolic process (GO:0019585)3.50784175
116positive regulation of lipid catabolic process (GO:0050996)3.49672308
117serine family amino acid biosynthetic process (GO:0009070)3.48693449
118regulation of transforming growth factor beta1 production (GO:0032908)3.48018682
119keratinization (GO:0031424)3.46479765
120carboxylic acid catabolic process (GO:0046395)3.44962625
121organic acid catabolic process (GO:0016054)3.44962625
122plasma lipoprotein particle organization (GO:0071827)3.43553939
123cholesterol homeostasis (GO:0042632)3.43018997
124low-density lipoprotein particle remodeling (GO:0034374)3.42753616
125phospholipid homeostasis (GO:0055091)3.41197825
126positive regulation of interleukin-8 secretion (GO:2000484)3.40202199
127regulation of bile acid biosynthetic process (GO:0070857)3.38308267
128hair follicle morphogenesis (GO:0031069)3.37995878
129phosphatidylcholine acyl-chain remodeling (GO:0036151)3.34021010
130long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24904598
131retinol metabolic process (GO:0042572)3.23205366
132defense response to fungus (GO:0050832)3.22227321
133gap junction assembly (GO:0016264)3.19803407
134surfactant homeostasis (GO:0043129)3.18825123
135positive regulation of transforming growth factor beta production (GO:0071636)3.18450290
136lateral sprouting from an epithelium (GO:0060601)3.17876270
137establishment of planar polarity (GO:0001736)3.16780741
138establishment of tissue polarity (GO:0007164)3.16780741
139positive regulation of humoral immune response (GO:0002922)3.14498784
140epithelium development (GO:0060429)3.14002967
141detection of bacterium (GO:0016045)3.11004946
142positive regulation of epidermal cell differentiation (GO:0045606)3.04353549
143positive regulation of p38MAPK cascade (GO:1900745)3.00080683
144phospholipid catabolic process (GO:0009395)2.99706901
145ectoderm development (GO:0007398)2.97861224
146ceramide biosynthetic process (GO:0046513)2.97408938
147long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.95541939
148positive regulation of keratinocyte differentiation (GO:0045618)2.95063593
149positive regulation of cholesterol efflux (GO:0010875)2.93290627
150positive regulation of chemokine secretion (GO:0090197)2.93061123
151chemical homeostasis within a tissue (GO:0048875)2.92207705
152phosphatidylserine metabolic process (GO:0006658)2.91518096
153polyol transport (GO:0015791)2.87155002
154regulation of chemokine secretion (GO:0090196)2.85068813
155positive regulation of epidermis development (GO:0045684)2.81280274
156fatty-acyl-CoA biosynthetic process (GO:0046949)2.79956253
157response to phenylpropanoid (GO:0080184)2.79309526
158negative regulation of interferon-gamma production (GO:0032689)2.79001807
159detection of other organism (GO:0098543)2.73657666
160defense response to Gram-negative bacterium (GO:0050829)2.68054060
161regulation of epidermis development (GO:0045682)2.67117675
162regulation of epidermal cell differentiation (GO:0045604)2.66589520
163epithelial cell proliferation (GO:0050673)2.65411618
164very-low-density lipoprotein particle assembly (GO:0034379)2.62639274
165primary alcohol metabolic process (GO:0034308)2.59434926
166positive regulation of sterol transport (GO:0032373)2.57344176
167positive regulation of cholesterol transport (GO:0032376)2.57344176
168molting cycle process (GO:0022404)2.55667430
169hair cycle process (GO:0022405)2.55667430
170negative regulation of keratinocyte proliferation (GO:0010839)2.55228169
171lung epithelium development (GO:0060428)2.54866492
172regulation of cellular amide metabolic process (GO:0034248)2.51248701
173regulation of neuron projection regeneration (GO:0070570)2.51112412
174regulation of axon regeneration (GO:0048679)2.51112412
175positive regulation of collagen biosynthetic process (GO:0032967)2.50028863
176low-density lipoprotein particle clearance (GO:0034383)2.45635647
177regulation of glomerulus development (GO:0090192)2.44228195
178alditol phosphate metabolic process (GO:0052646)2.42029849
179negative regulation of heart growth (GO:0061117)2.40125997
180negative regulation of cardiac muscle tissue growth (GO:0055022)2.40125997
181desmosome organization (GO:0002934)13.3476362
182keratinocyte proliferation (GO:0043616)10.3172759
183multicellular organismal water homeostasis (GO:0050891)10.0847780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.31378666
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.41754534
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.37495982
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.74900011
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.73542839
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35565878
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.10606244
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74851215
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35203245
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95881452
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.78691927
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.53343786
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.52766006
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34445023
15RXR_22108803_ChIP-Seq_LS180_Human2.12420329
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03527022
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03527022
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03473515
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5223813
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80030161
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77729395
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76647711
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71126947
24HTT_18923047_ChIP-ChIP_STHdh_Human1.67726559
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.66408109
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65880495
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.50064205
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48603345
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.48151772
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41797746
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40386408
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37627446
33CLOCK_20551151_ChIP-Seq_293T_Human1.34849860
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.34648271
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30899917
36AR_21572438_ChIP-Seq_LNCaP_Human1.22574882
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18376619
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.16960790
39GATA4_25053715_ChIP-Seq_YYC3_Human1.15574496
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12976683
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.12258957
42* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11901456
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11540483
44ATF3_27146783_Chip-Seq_COLON_Human1.11439526
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10313166
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09865366
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08690546
48KLF5_25053715_ChIP-Seq_YYC3_Human1.08677815
49GATA1_22025678_ChIP-Seq_K562_Human1.07919941
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05569580
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04143832
52RACK7_27058665_Chip-Seq_MCF-7_Human1.02047830
53CEBPB_22108803_ChIP-Seq_LS180_Human1.00784077
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00508977
55TP53_16413492_ChIP-PET_HCT116_Human0.99118294
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98043185
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97811803
58CDX2_20551321_ChIP-Seq_CACO-2_Human0.95136374
59PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94126926
60* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93561398
61TAF15_26573619_Chip-Seq_HEK293_Human0.89178054
62AHR_22903824_ChIP-Seq_MCF-7_Human0.88483254
63CJUN_26792858_Chip-Seq_BT549_Human0.87232713
64SOX2_20726797_ChIP-Seq_SW620_Human0.86670691
65ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86269943
66TRIM28_21343339_ChIP-Seq_HEK293_Human0.86211371
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85565716
68ZNF263_19887448_ChIP-Seq_K562_Human0.85282861
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83675790
70TP63_23658742_ChIP-Seq_EP156T_Human0.81750907
71CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81269940
72CTCF_20526341_ChIP-Seq_ESCs_Human0.81175372
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81042676
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80788177
75SMC4_20622854_ChIP-Seq_HELA_Human0.79823835
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79447884
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.78275667
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77858210
79GATA3_24758297_ChIP-Seq_MCF-7_Human0.76422924
80LXR_22292898_ChIP-Seq_THP-1_Human0.76413238
81BCAT_22108803_ChIP-Seq_LS180_Human0.76335396
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75858322
83ERG_20517297_ChIP-Seq_VCAP_Human0.75796237
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75670044
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74559923
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74159443
87BCOR_27268052_Chip-Seq_Bcells_Human0.73350480
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73298654
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73129732
90FOXA1_25552417_ChIP-Seq_VCAP_Human0.71256669
91TAF2_19829295_ChIP-Seq_ESCs_Human0.70791321
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70490555
93* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70337504
94* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70337504
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70027070
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.69591704
97P53_21459846_ChIP-Seq_SAOS-2_Human0.68705035
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68090440
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67980473
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67266127
101SMAD4_21741376_ChIP-Seq_ESCs_Human0.65941800
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65807334
103CDX2_22108803_ChIP-Seq_LS180_Human0.65416740
104GATA6_21074721_ChIP-Seq_CACO-2_Human0.64030390
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.62883177
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62667438
107E2F1_20622854_ChIP-Seq_HELA_Human0.62370899
108FOXH1_21741376_ChIP-Seq_ESCs_Human0.62359418
109MYC_19915707_ChIP-ChIP_AK7_Human0.62294168
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.61748287
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61503118
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.61251704
113CBP_21632823_ChIP-Seq_H3396_Human0.57216842
114CTCF_27219007_Chip-Seq_Bcells_Human0.57004209
115P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56692189
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56627190
117EGR1_19032775_ChIP-ChIP_M12_Human0.55354733
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55269203
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.54720596
120TP53_18474530_ChIP-ChIP_U2OS_Human0.54538383
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54519639
122TP63_22573176_ChIP-Seq_HFKS_Human0.54102539
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.54079486
124HNFA_21074721_ChIP-Seq_CACO-2_Human0.53639603
125GATA6_25053715_ChIP-Seq_YYC3_Human0.53034497
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.52850432
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.52757582
128FOXH1_21741376_ChIP-Seq_EPCs_Human0.51332742
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.51321226
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.51204435
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.51093086
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49866007
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49131706
134ERA_21632823_ChIP-Seq_H3396_Human0.49125530
135AR_20517297_ChIP-Seq_VCAP_Human0.49075635
136CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.49018849
137GATA2_19941826_ChIP-Seq_K562_Human0.48924982
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.48916966
139* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48617482
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.47812477
141* STAT1_17558387_ChIP-Seq_HELA_Human0.47103293
142TCF4_22108803_ChIP-Seq_LS180_Human0.46529833
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46430370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.00206436
2MP0005360_urolithiasis6.34564677
3MP0005085_abnormal_gallbladder_physiolo5.49531686
4MP0005365_abnormal_bile_salt5.17255015
5MP0002796_impaired_skin_barrier4.50954298
6MP0005451_abnormal_body_composition3.96960505
7MP0010234_abnormal_vibrissa_follicle3.93160046
8MP0008875_abnormal_xenobiotic_pharmacok3.84802285
9MP0003191_abnormal_cellular_cholesterol3.71842959
10MP0003806_abnormal_nucleotide_metabolis3.53141983
11MP0003252_abnormal_bile_duct3.50775611
12MP0000566_synostosis3.18816585
13MP0001188_hyperpigmentation2.99128398
14MP0010329_abnormal_lipoprotein_level2.99003095
15MP0005275_abnormal_skin_tensile2.64563661
16MP0009840_abnormal_foam_cell2.53726233
17MP0005501_abnormal_skin_physiology2.50748739
18MP0003941_abnormal_skin_development2.48577766
19MP0003195_calcinosis2.45865369
20MP0000015_abnormal_ear_pigmentation2.35363636
21MP0005083_abnormal_biliary_tract2.25483297
22MP0001666_abnormal_nutrient_absorption2.24652080
23MP0004381_abnormal_hair_follicle2.22691664
24MP0005174_abnormal_tail_pigmentation2.18669082
25MP0005332_abnormal_amino_acid2.16058963
26MP0002095_abnormal_skin_pigmentation2.11358079
27MP0004019_abnormal_vitamin_homeostasis1.82078641
28MP0002118_abnormal_lipid_homeostasis1.81998732
29MP0005409_darkened_coat_color1.80205081
30MP0000609_abnormal_liver_physiology1.78671152
31MP0002060_abnormal_skin_morphology1.67839653
32MP0002254_reproductive_system_inflammat1.66314066
33MP0004947_skin_inflammation1.66125547
34MP0002138_abnormal_hepatobiliary_system1.47554789
35MP0003868_abnormal_feces_composition1.43862067
36MP0005319_abnormal_enzyme/_coenzyme1.41812676
37MP0001216_abnormal_epidermal_layer1.38117982
38MP0004782_abnormal_surfactant_physiolog1.36904656
39MP0010771_integument_phenotype1.34656529
40MP0003705_abnormal_hypodermis_morpholog1.34150799
41MP0010678_abnormal_skin_adnexa1.30075664
42MP0000647_abnormal_sebaceous_gland1.20710987
43MP0001764_abnormal_homeostasis1.17227163
44MP0005647_abnormal_sex_gland1.16674638
45MP0000579_abnormal_nail_morphology1.14142041
46MP0003011_delayed_dark_adaptation1.14109832
47MP0005584_abnormal_enzyme/coenzyme_acti1.10753797
48MP0009697_abnormal_copulation1.06556343
49MP0009780_abnormal_chondrocyte_physiolo1.04329626
50MP0003566_abnormal_cell_adhesion1.02644140
51MP0002098_abnormal_vibrissa_morphology1.00997371
52MP0003950_abnormal_plasma_membrane0.98913834
53MP0002876_abnormal_thyroid_physiology0.98881289
54MP0000604_amyloidosis0.96171155
55MP0003453_abnormal_keratinocyte_physiol0.95962390
56MP0002177_abnormal_outer_ear0.94467641
57MP0000427_abnormal_hair_cycle0.93377475
58MP0009643_abnormal_urine_homeostasis0.90720114
59MP0009764_decreased_sensitivity_to0.90300092
60MP0000377_abnormal_hair_follicle0.89891439
61MP0001984_abnormal_olfaction0.88564150
62MP0009931_abnormal_skin_appearance0.87994310
63MP0010368_abnormal_lymphatic_system0.85579200
64MP0004185_abnormal_adipocyte_glucose0.85542892
65MP0000762_abnormal_tongue_morphology0.80569022
66MP0009379_abnormal_foot_pigmentation0.79956396
67MP0003656_abnormal_erythrocyte_physiolo0.79276788
68MP0000598_abnormal_liver_morphology0.78047972
69MP0003329_amyloid_beta_deposits0.77427117
70MP0003186_abnormal_redox_activity0.77263528
71MP0001191_abnormal_skin_condition0.75464994
72MP0005670_abnormal_white_adipose0.72337691
73MP0009763_increased_sensitivity_to0.72202395
74MP0005636_abnormal_mineral_homeostasis0.70456658
75MP0001784_abnormal_fluid_regulation0.68110243
76MP0002009_preneoplasia0.67816508
77MP0008469_abnormal_protein_level0.67319434
78MP0001851_eye_inflammation0.65176004
79MP0009765_abnormal_xenobiotic_induced0.63449822
80MP0002971_abnormal_brown_adipose0.63139245
81MP0009642_abnormal_blood_homeostasis0.62811536
82MP0001243_abnormal_dermal_layer0.62437186
83MP0005408_hypopigmentation0.61792079
84MP0009384_cardiac_valve_regurgitation0.60822032
85MP0005023_abnormal_wound_healing0.59117745
86MP0000465_gastrointestinal_hemorrhage0.58135828
87MP0005220_abnormal_exocrine_pancreas0.57179596
88MP0010030_abnormal_orbit_morphology0.55595368
89MP0000383_abnormal_hair_follicle0.55404771
90MP0005257_abnormal_intraocular_pressure0.55150049
91MP0002822_catalepsy0.54989920
92MP0003878_abnormal_ear_physiology0.54541234
93MP0005377_hearing/vestibular/ear_phenot0.54541234
94MP0005666_abnormal_adipose_tissue0.54311891
95MP0000367_abnormal_coat/_hair0.52977977
96MP0005334_abnormal_fat_pad0.52808935
97MP0004130_abnormal_muscle_cell0.52440820
98MP0001340_abnormal_eyelid_morphology0.51034478
99MP0002078_abnormal_glucose_homeostasis0.50918177
100MP0009672_abnormal_birth_weight0.49885337
101MP0009053_abnormal_anal_canal0.49594674
102MP0005376_homeostasis/metabolism_phenot0.49357539
103MP0005535_abnormal_body_temperature0.48494993
104MP0000467_abnormal_esophagus_morphology0.47706250
105MP0003638_abnormal_response/metabolism_0.46328713
106MP0005187_abnormal_penis_morphology0.44602089
107MP0005075_abnormal_melanosome_morpholog0.44039096
108MP0003690_abnormal_glial_cell0.44022121
109MP0002089_abnormal_postnatal_growth/wei0.43100003
110MP0009333_abnormal_splenocyte_physiolog0.42842921
111MP0006036_abnormal_mitochondrial_physio0.41895977
112MP0004264_abnormal_extraembryonic_tissu0.40791116
113MP0005076_abnormal_cell_differentiation0.39572067
114MP0004272_abnormal_basement_membrane0.39474766
115MP0002090_abnormal_vision0.39461873
116MP0002132_abnormal_respiratory_system0.39228987
117MP0005266_abnormal_metabolism0.39085152
118MP0005171_absent_coat_pigmentation0.37869256
119MP0001186_pigmentation_phenotype0.37207598
120MP0005448_abnormal_energy_balance0.37011287
121MP0008961_abnormal_basal_metabolism0.36572355
122MP0001177_atelectasis0.35780291
123MP0003718_maternal_effect0.35225866
124MP0002233_abnormal_nose_morphology0.35181023
125MP0005084_abnormal_gallbladder_morpholo0.34480091
126MP0008873_increased_physiological_sensi0.34112486
127MP0003075_altered_response_to0.31793372
128MP0001756_abnormal_urination0.31250815
129MP0002111_abnormal_tail_morphology0.31192445
130MP0002282_abnormal_trachea_morphology0.31177074
131MP0000372_irregular_coat_pigmentation0.31134224
132MP0008874_decreased_physiological_sensi0.31091128
133MP0005166_decreased_susceptibility_to0.29506184
134MP0000428_abnormal_craniofacial_morphol0.29012321
135MP0003122_maternal_imprinting0.27837656
136MP0002166_altered_tumor_susceptibility0.27372265
137MP0000627_abnormal_mammary_gland0.27285372
138MP0004885_abnormal_endolymph0.26911807
139MP0001299_abnormal_eye_distance/0.25713180
140MP0003763_abnormal_thymus_physiology0.25350997
141MP0002092_abnormal_eye_morphology0.25310403
142MP0003315_abnormal_perineum_morphology0.24068452
143MP0003567_abnormal_fetal_cardiomyocyte0.23238521
144MP0008438_abnormal_cutaneous_collagen0.22596296
145MP0005197_abnormal_uvea_morphology0.22141445
146MP0002697_abnormal_eye_size0.21144041
147MP0000371_diluted_coat_color0.20908191
148MP0002234_abnormal_pharynx_morphology0.19146084
149MP0002006_tumorigenesis0.18922102
150MP0000462_abnormal_digestive_system0.18131794
151MP0001853_heart_inflammation0.16807487
152MP0008789_abnormal_olfactory_epithelium0.16071561
153MP0003755_abnormal_palate_morphology0.15519080
154MP0002877_abnormal_melanocyte_morpholog0.15412666
155MP0000685_abnormal_immune_system0.15246587

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)8.17733189
2Palmar hyperkeratosis (HP:0010765)7.79306858
3Intrahepatic cholestasis (HP:0001406)7.17917791
4Erythema (HP:0010783)7.17783597
5Deep venous thrombosis (HP:0002625)6.81591211
6Plantar hyperkeratosis (HP:0007556)6.69297428
7Conjunctival hamartoma (HP:0100780)6.56103402
8Abnormality of aromatic amino acid family metabolism (HP:0004338)6.51684447
9Prolonged partial thromboplastin time (HP:0003645)6.15120265
10Abnormality of monocarboxylic acid metabolism (HP:0010996)6.09321299
11Hypobetalipoproteinemia (HP:0003563)5.90201223
12Complement deficiency (HP:0004431)5.87693862
13Xanthomatosis (HP:0000991)5.87356247
14Thick nail (HP:0001805)5.28259902
15Abnormality of secondary sexual hair (HP:0009888)5.02137582
16Abnormality of the axillary hair (HP:0100134)5.02137582
17Hyperlipoproteinemia (HP:0010980)4.93255344
18Woolly hair (HP:0002224)4.90263685
19Congenital ichthyosiform erythroderma (HP:0007431)4.80641728
20Fragile nails (HP:0001808)4.67628360
21Abnormality of complement system (HP:0005339)4.57988072
22Alopecia of scalp (HP:0002293)4.53251650
23Hypolipoproteinemia (HP:0010981)4.39350410
24Onycholysis (HP:0001806)4.39076108
25Hamartoma of the eye (HP:0010568)4.37154172
26Epidermoid cyst (HP:0200040)4.26621652
27Palmoplantar keratoderma (HP:0000982)4.26537094
28Joint hemorrhage (HP:0005261)4.23514894
29Fat malabsorption (HP:0002630)4.13070166
30Abnormality of the common coagulation pathway (HP:0010990)4.07292712
31Hyperammonemia (HP:0001987)4.00269453
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.94722989
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93908787
34Increased IgE level (HP:0003212)3.92820472
35Hyperglycinemia (HP:0002154)3.82903212
36Abnormal blistering of the skin (HP:0008066)3.81443436
37Hypoalphalipoproteinemia (HP:0003233)3.81106091
38Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78513101
39Ketosis (HP:0001946)3.68070045
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.64892781
41Eczematoid dermatitis (HP:0000976)3.62544427
42Conjugated hyperbilirubinemia (HP:0002908)3.52319341
43Abnormality of methionine metabolism (HP:0010901)3.51462671
44Abnormality of the intrinsic pathway (HP:0010989)3.47023176
45Abnormality of aspartate family amino acid metabolism (HP:0010899)3.46844362
46Hyperglycinuria (HP:0003108)3.44366579
47Hypoglycemic coma (HP:0001325)3.42721946
48Gangrene (HP:0100758)3.39909278
49Abnormality of glycine metabolism (HP:0010895)3.39834956
50Abnormality of serine family amino acid metabolism (HP:0010894)3.39834956
51Steatorrhea (HP:0002570)3.27933613
52Hypohidrosis (HP:0000966)3.23241200
53Sparse scalp hair (HP:0002209)3.16915721
54Aplasia involving bones of the upper limbs (HP:0009823)3.13915654
55Aplasia of the phalanges of the hand (HP:0009802)3.13915654
56Aplasia involving bones of the extremities (HP:0009825)3.13915654
57Hypercholesterolemia (HP:0003124)3.12122306
58Abnormality of pyrimidine metabolism (HP:0004353)3.11906049
59Abnormality of the salivary glands (HP:0010286)3.11528636
60Systemic lupus erythematosus (HP:0002725)3.03184454
61Abnormality of fatty-acid metabolism (HP:0004359)3.01956131
62Erythroderma (HP:0001019)3.00579007
63Pili torti (HP:0003777)2.98106036
64Lip pit (HP:0100267)2.96603017
65Abnormal hair laboratory examination (HP:0003328)2.93155605
66Abnormality of nail color (HP:0100643)2.89546230
67Hyperbilirubinemia (HP:0002904)2.86980070
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85424161
69Hypochromic microcytic anemia (HP:0004840)2.84028442
70Nail dystrophy (HP:0008404)2.78344825
71Absent eyelashes (HP:0000561)2.76488542
72Myocardial infarction (HP:0001658)2.75759139
73Sparse eyelashes (HP:0000653)2.72050563
74Vascular calcification (HP:0004934)2.70285217
75Delayed CNS myelination (HP:0002188)2.68437967
76Abnormality of nucleobase metabolism (HP:0010932)2.67898640
77Recurrent gram-negative bacterial infections (HP:0005420)2.67460294
78Nasolacrimal duct obstruction (HP:0000579)2.66528357
79Oral leukoplakia (HP:0002745)2.63221166
80Ketoacidosis (HP:0001993)2.60207356
81Spontaneous abortion (HP:0005268)2.59990469
82Cholecystitis (HP:0001082)2.59465875
83Abnormal gallbladder physiology (HP:0012438)2.59465875
84Natal tooth (HP:0000695)2.51909118
85Hamartoma (HP:0010566)2.51516826
86Hepatocellular carcinoma (HP:0001402)2.50560692
87Conical tooth (HP:0000698)2.50414891
88Pruritus (HP:0000989)2.48862572
89Melanocytic nevus (HP:0000995)2.48654091
90Amyloidosis (HP:0011034)2.47999410
91Abnormality of permanent molar morphology (HP:0011071)2.47973642
92Abnormality of the dental root (HP:0006486)2.47973642
93Taurodontia (HP:0000679)2.47973642
94Abnormality of purine metabolism (HP:0004352)2.45894935
95Dry hair (HP:0011359)2.45682024
96Abnormality of serum amino acid levels (HP:0003112)2.44907084
97Cardiovascular calcification (HP:0011915)2.41009476
98Hypergammaglobulinemia (HP:0010702)2.40012054
99Advanced eruption of teeth (HP:0006288)2.39192428
100Neonatal onset (HP:0003623)2.39146178
101Hyperhidrosis (HP:0000975)2.36541038
102Skin nodule (HP:0200036)2.34898301
103Metabolic acidosis (HP:0001942)2.34194171
104Mitral stenosis (HP:0001718)2.33410135
105Abnormality of molar (HP:0011077)2.30701661
106Abnormality of molar morphology (HP:0011070)2.30701661
107Abnormality of the lacrimal duct (HP:0011481)2.29217339
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25821156
109Dicarboxylic aciduria (HP:0003215)2.25821156
110Malnutrition (HP:0004395)2.24429793
111Abnormal gallbladder morphology (HP:0012437)2.23678635
112Corneal erosion (HP:0200020)2.23346808
113Hypophosphatemic rickets (HP:0004912)2.22270764
114Neonatal death (HP:0003811)2.21423632
115Abnormality of the dental pulp (HP:0006479)2.21277828
116Xerostomia (HP:0000217)2.21117208
117Parakeratosis (HP:0001036)2.20930654
118Ectropion (HP:0000656)2.20576111
119Follicular hyperkeratosis (HP:0007502)2.20388340
120Cholelithiasis (HP:0001081)2.19410446
121Selective tooth agenesis (HP:0001592)2.18873381
122Spastic diplegia (HP:0001264)2.18570555
123Hypotrichosis (HP:0001006)2.17965401
124Lethargy (HP:0001254)2.17605959
125Right ventricular cardiomyopathy (HP:0011663)2.17089112
126Rickets (HP:0002748)2.16231702
127Gout (HP:0001997)2.13434409
128Hypoglycemic seizures (HP:0002173)2.11946859
129Brushfield spots (HP:0001088)2.10262407
130Abnormality of hair growth rate (HP:0011363)2.07953183
131Slow-growing hair (HP:0002217)2.07953183
132Cerebral edema (HP:0002181)2.07228530
133Acanthocytosis (HP:0001927)2.06880920
134Milia (HP:0001056)2.05871415
135Irritability (HP:0000737)2.05531080
136Split foot (HP:0001839)2.03784973
137Late onset (HP:0003584)2.01726464
138Hypoplastic labia majora (HP:0000059)2.00139167
139Abnormality of the nasolacrimal system (HP:0000614)1.99660155
140Septate vagina (HP:0001153)1.98616039
141Absent hair (HP:0002298)1.98173932
142Sensorimotor neuropathy (HP:0007141)1.97191803
143Gingival bleeding (HP:0000225)1.96959810
144Lack of skin elasticity (HP:0100679)1.95765587
145Blepharitis (HP:0000498)1.95620892
146Abnormality of the gallbladder (HP:0005264)1.95037318
147Hydroxyprolinuria (HP:0003080)1.93762648
148Abnormality of proline metabolism (HP:0010907)1.93762648
149Abnormality of the Achilles tendon (HP:0005109)1.90345544
150Pancreatitis (HP:0001733)1.87159518
151Glomerulonephritis (HP:0000099)1.86582997
152Menorrhagia (HP:0000132)1.85612261
153Oligodontia (HP:0000677)1.85486169
154Curly hair (HP:0002212)1.85160571
155Opisthotonus (HP:0002179)1.83604210
156Broad alveolar ridges (HP:0000187)1.83243252
157Hyperinsulinemic hypoglycemia (HP:0000825)1.82338188
158Ridged nail (HP:0001807)1.81367204
159Abnormality of the labia majora (HP:0012881)1.80528013
160Abnormal cartilage morphology (HP:0002763)1.79968729
161Acanthosis nigricans (HP:0000956)1.78984922
162Duplicated collecting system (HP:0000081)1.78534159
163Dehydration (HP:0001944)1.78381343
164Brittle hair (HP:0002299)1.76196307
165Neonatal short-limb short stature (HP:0008921)1.74676081
166Skin ulcer (HP:0200042)1.71927825
167Alacrima (HP:0000522)1.71066401
168Laryngomalacia (HP:0001601)1.69936200
169Dry skin (HP:0000958)1.65651461
170Pustule (HP:0200039)1.64471915
171Abnormality of the alveolar ridges (HP:0006477)1.57563451
172Depressed nasal tip (HP:0000437)1.57426451
173Anonychia (HP:0001798)1.52120565
174Coarse hair (HP:0002208)1.51666377
175Abnormality of the renal collecting system (HP:0004742)1.47886391
176Seborrheic dermatitis (HP:0001051)1.43847676
177Ventricular tachycardia (HP:0004756)1.43016904
178Abnormality of incisor morphology (HP:0011063)1.41983818
179Hypoplasia of dental enamel (HP:0006297)1.40886559
180Coronal craniosynostosis (HP:0004440)1.40608804
181Recurrent corneal erosions (HP:0000495)1.40605181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.73952786
2STK245.60324249
3EPHA25.12977349
4EEF2K5.12838428
5ERN14.58184689
6FGFR44.15399710
7SIK14.09085181
8ERBB43.48065442
9MST1R3.39667809
10TGFBR13.13322503
11MAP2K42.60781038
12TAOK32.32083907
13PIK3CG2.29164377
14INSRR2.27403827
15MAP3K22.16312729
16LATS12.05136210
17TRPM71.82740847
18MAPKAPK31.79201648
19MAP3K31.73437036
20MAPK111.66633768
21MAPKAPK51.64853983
22MAP3K71.64145291
23ICK1.64060580
24PTK61.56821941
25FGFR21.54619216
26SGK2231.50069090
27SGK4941.50069090
28TYK21.47705188
29RPS6KB21.43365017
30FGFR11.38144725
31MAP3K111.37313810
32TRIB31.32843096
33DYRK1B1.32653321
34MAP3K141.31200130
35AKT31.30579906
36STK38L1.25578660
37WNK11.23186129
38CDK121.20875204
39JAK21.17600229
40ABL21.13042612
41MAP3K101.11229746
42PKN21.10096682
43ERBB21.05644804
44NEK91.05389820
45RPS6KB11.04074672
46PRKAA21.03966347
47TBK11.02364827
48SGK21.01118647
49PINK10.96977515
50MET0.94805267
51MAP2K30.94001759
52JAK10.93145377
53FRK0.92685974
54CDK60.89897723
55MAPK40.89752641
56RIPK10.89178307
57LATS20.88794299
58PKN10.86614540
59PRPF4B0.85595644
60FLT30.84598668
61ITK0.83573721
62DAPK20.83456453
63SGK30.80956701
64EPHB10.77895637
65PAK30.75932248
66MAPK150.73138972
67PRKCZ0.72790530
68EPHA30.71684793
69MAP2K60.70490644
70IRAK10.70311664
71MAPK120.69827950
72MTOR0.69289321
73GRK50.69179945
74NLK0.68853233
75GRK60.68601838
76PRKACG0.67221463
77MAP2K10.65853358
78FER0.65574969
79MAP3K50.64001248
80PIK3CA0.59338565
81SYK0.58886546
82FGFR30.57526471
83MAPKAPK20.57348084
84EPHA40.56938815
85TGFBR20.56484532
86CAMK2G0.56169039
87MAP3K90.55734909
88IKBKE0.55716050
89SGK10.55591446
90GSK3A0.54823590
91KDR0.54456827
92GRK70.53854451
93MAP3K10.53544483
94MOS0.53477712
95STK380.52698476
96PDGFRB0.51407073
97IRAK20.50644932
98ADRBK10.49160139
99PTK20.46983463
100PRKCH0.45938587
101IRAK30.45807207
102TIE10.44675245
103CAMK1D0.44244249
104PRKCQ0.43668057
105KIT0.43462026
106TYRO30.43440936
107DYRK30.43149631
108MINK10.42001092
109WNK40.40688832
110BMX0.40551139
111PRKCE0.40439401
112PRKCG0.39364977
113CSK0.39195805
114LRRK20.38601579
115EGFR0.38365474
116MST40.36778403
117MAPK70.35669226
118PIM20.35363148
119PRKAA10.35221420
120ABL10.35187254
121BCR0.34782189
122PDGFRA0.34480399
123MAP3K60.34270294
124CSNK1D0.34224101
125PRKCA0.33560229
126IGF1R0.33315642
127STK30.32339040
128RET0.31637525
129STK100.31233022
130BRD40.30286309
131TAOK10.30231901
132NEK60.29786463
133BMPR20.29711331
134PRKD10.28859928
135MAP3K120.27838500
136MARK20.27264538
137GRK10.27181100
138CDK30.27078333
139CDK70.26966784
140CSNK1E0.25801664
141IKBKB0.23677251
142CAMK40.23386080
143MAPK90.22379065
144BRSK20.21503265
145PRKD20.20717875
146CHUK0.20093348
147DDR20.18001808
148PBK0.17765191
149IRAK40.15659331

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.88307252
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25687170
3Nitrogen metabolism_Homo sapiens_hsa009103.20541181
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10194655
5Arginine biosynthesis_Homo sapiens_hsa002203.01426222
6Complement and coagulation cascades_Homo sapiens_hsa046102.87895328
7Tryptophan metabolism_Homo sapiens_hsa003802.65837320
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56219566
9Fatty acid degradation_Homo sapiens_hsa000712.49012634
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47664437
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45021670
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34693049
13Histidine metabolism_Homo sapiens_hsa003402.13865173
14Peroxisome_Homo sapiens_hsa041462.13178262
15Butanoate metabolism_Homo sapiens_hsa006502.10237315
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07074511
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04793500
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.97438851
19Fatty acid elongation_Homo sapiens_hsa000621.88977656
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.87157022
21PPAR signaling pathway_Homo sapiens_hsa033201.86059287
22Chemical carcinogenesis_Homo sapiens_hsa052041.84739807
23Retinol metabolism_Homo sapiens_hsa008301.81907222
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81800094
25Fatty acid metabolism_Homo sapiens_hsa012121.80293596
26Staphylococcus aureus infection_Homo sapiens_hsa051501.79852747
27Propanoate metabolism_Homo sapiens_hsa006401.77271691
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69025521
29ABC transporters_Homo sapiens_hsa020101.68064764
30GnRH signaling pathway_Homo sapiens_hsa049121.65403742
31beta-Alanine metabolism_Homo sapiens_hsa004101.58134494
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57496972
33Phenylalanine metabolism_Homo sapiens_hsa003601.55394553
34Caffeine metabolism_Homo sapiens_hsa002321.54460926
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.53244846
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49631287
37Tyrosine metabolism_Homo sapiens_hsa003501.48171761
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43626174
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42433394
40Bile secretion_Homo sapiens_hsa049761.42106097
41Selenocompound metabolism_Homo sapiens_hsa004501.41859306
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41359114
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36099589
44Fat digestion and absorption_Homo sapiens_hsa049751.34331351
45VEGF signaling pathway_Homo sapiens_hsa043701.31729406
46Sulfur metabolism_Homo sapiens_hsa009201.30849208
47Pyruvate metabolism_Homo sapiens_hsa006201.20428523
48Starch and sucrose metabolism_Homo sapiens_hsa005001.17306102
49Folate biosynthesis_Homo sapiens_hsa007901.16567040
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10427064
51Steroid biosynthesis_Homo sapiens_hsa001001.08185418
52Dorso-ventral axis formation_Homo sapiens_hsa043201.08027530
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.06853186
54Long-term depression_Homo sapiens_hsa047301.06126427
55Biosynthesis of amino acids_Homo sapiens_hsa012301.04186581
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.02962161
57Choline metabolism in cancer_Homo sapiens_hsa052310.97751500
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.97305388
59Carbon metabolism_Homo sapiens_hsa012000.97268279
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95832172
61Vitamin B6 metabolism_Homo sapiens_hsa007500.94277155
62Phototransduction_Homo sapiens_hsa047440.94157316
63ECM-receptor interaction_Homo sapiens_hsa045120.90216024
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88097174
65Sulfur relay system_Homo sapiens_hsa041220.86325951
66Renin secretion_Homo sapiens_hsa049240.83809347
67Glutathione metabolism_Homo sapiens_hsa004800.83432395
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81822549
69Glycerolipid metabolism_Homo sapiens_hsa005610.81104391
70Ras signaling pathway_Homo sapiens_hsa040140.80155159
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78419231
72Arginine and proline metabolism_Homo sapiens_hsa003300.78100084
73Vitamin digestion and absorption_Homo sapiens_hsa049770.77556130
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76268184
75Linoleic acid metabolism_Homo sapiens_hsa005910.72645916
76Serotonergic synapse_Homo sapiens_hsa047260.71157690
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68828759
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68393647
79Lysine degradation_Homo sapiens_hsa003100.66001727
80p53 signaling pathway_Homo sapiens_hsa041150.64219892
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.63006368
82Fatty acid biosynthesis_Homo sapiens_hsa000610.62232846
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60649127
84Inositol phosphate metabolism_Homo sapiens_hsa005620.59806295
85Prion diseases_Homo sapiens_hsa050200.58709268
86One carbon pool by folate_Homo sapiens_hsa006700.56752182
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56640376
88Adherens junction_Homo sapiens_hsa045200.56604956
89Platelet activation_Homo sapiens_hsa046110.56574677
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55478056
91Tight junction_Homo sapiens_hsa045300.50854663
92MicroRNAs in cancer_Homo sapiens_hsa052060.50317159
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48277816
94Endocytosis_Homo sapiens_hsa041440.46553306
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45974535
96Metabolic pathways_Homo sapiens_hsa011000.45083293
97Melanogenesis_Homo sapiens_hsa049160.42681283
98Pentose phosphate pathway_Homo sapiens_hsa000300.42066537
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.38479786
100Thyroid cancer_Homo sapiens_hsa052160.37992543
101Glutamatergic synapse_Homo sapiens_hsa047240.37304328
102Arachidonic acid metabolism_Homo sapiens_hsa005900.35761868
103Oxytocin signaling pathway_Homo sapiens_hsa049210.34650097
104Glioma_Homo sapiens_hsa052140.34342832
105Proteoglycans in cancer_Homo sapiens_hsa052050.34081829
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.33134681
107Long-term potentiation_Homo sapiens_hsa047200.32939936
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29971227
109MAPK signaling pathway_Homo sapiens_hsa040100.29700504
110Basal cell carcinoma_Homo sapiens_hsa052170.26500159
111FoxO signaling pathway_Homo sapiens_hsa040680.25638568
112Notch signaling pathway_Homo sapiens_hsa043300.25637684
113Acute myeloid leukemia_Homo sapiens_hsa052210.25217886
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25062630
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24976882
116Hippo signaling pathway_Homo sapiens_hsa043900.24198081
117Insulin resistance_Homo sapiens_hsa049310.23783522
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23741947
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.22847764
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.22292329
121Ether lipid metabolism_Homo sapiens_hsa005650.15741248
122Sphingolipid metabolism_Homo sapiens_hsa006000.09045664
123Galactose metabolism_Homo sapiens_hsa000520.08391586
124Glucagon signaling pathway_Homo sapiens_hsa049220.07726802
125Fructose and mannose metabolism_Homo sapiens_hsa000510.07401894
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2352657
127Mineral absorption_Homo sapiens_hsa04978-0.2282886
128Renin-angiotensin system_Homo sapiens_hsa04614-0.2217557
129Regulation of autophagy_Homo sapiens_hsa04140-0.1999535
130Pertussis_Homo sapiens_hsa05133-0.1981557
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1945494
132Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1934874
133Circadian rhythm_Homo sapiens_hsa04710-0.1856531
134Lysosome_Homo sapiens_hsa04142-0.1819358
135Bladder cancer_Homo sapiens_hsa05219-0.1600338
136Insulin signaling pathway_Homo sapiens_hsa04910-0.1529679
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1325555
138Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1315151
139Amoebiasis_Homo sapiens_hsa05146-0.1126641
140African trypanosomiasis_Homo sapiens_hsa05143-0.0821385
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0570466
142Hepatitis C_Homo sapiens_hsa05160-0.0515893
143AMPK signaling pathway_Homo sapiens_hsa04152-0.0402252
144Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0151374

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