SERPINA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.46878623
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61402865
3L-phenylalanine catabolic process (GO:0006559)7.61402865
4epoxygenase P450 pathway (GO:0019373)7.39324842
5L-phenylalanine metabolic process (GO:0006558)7.23736007
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23736007
7omega-hydroxylase P450 pathway (GO:0097267)7.13005578
8aromatic amino acid family catabolic process (GO:0009074)6.78627210
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24072847
10tryptophan catabolic process (GO:0006569)6.09239875
11indole-containing compound catabolic process (GO:0042436)6.09239875
12indolalkylamine catabolic process (GO:0046218)6.09239875
13oxidative demethylation (GO:0070989)5.93371899
14kynurenine metabolic process (GO:0070189)5.88269714
15tryptophan metabolic process (GO:0006568)5.78207304
16bile acid biosynthetic process (GO:0006699)5.77833413
17drug metabolic process (GO:0017144)5.69681077
18negative regulation of fibrinolysis (GO:0051918)5.69502201
19uronic acid metabolic process (GO:0006063)5.67771081
20high-density lipoprotein particle remodeling (GO:0034375)5.60760860
21glyoxylate metabolic process (GO:0046487)5.58537723
22regulation of fibrinolysis (GO:0051917)5.58311680
23regulation of protein activation cascade (GO:2000257)5.55300822
24urea cycle (GO:0000050)5.50673109
25urea metabolic process (GO:0019627)5.50673109
26complement activation, alternative pathway (GO:0006957)5.49563668
27protein carboxylation (GO:0018214)5.46272978
28peptidyl-glutamic acid carboxylation (GO:0017187)5.46272978
29alpha-linolenic acid metabolic process (GO:0036109)5.23701214
30regulation of complement activation (GO:0030449)5.12141748
31phenylpropanoid metabolic process (GO:0009698)5.10918532
32nitrogen cycle metabolic process (GO:0071941)5.06488158
33cysteine metabolic process (GO:0006534)5.04332644
34sulfur amino acid catabolic process (GO:0000098)4.99409302
35bile acid metabolic process (GO:0008206)4.97294774
36aromatic amino acid family metabolic process (GO:0009072)4.94490999
37reverse cholesterol transport (GO:0043691)4.93713463
38regulation of cholesterol esterification (GO:0010872)4.93248043
39serine family amino acid catabolic process (GO:0009071)4.84589145
40tyrosine metabolic process (GO:0006570)4.81830613
41protein-lipid complex remodeling (GO:0034368)4.81525660
42macromolecular complex remodeling (GO:0034367)4.81525660
43plasma lipoprotein particle remodeling (GO:0034369)4.81525660
44regulation of triglyceride catabolic process (GO:0010896)4.75550331
45phospholipid efflux (GO:0033700)4.70067135
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68825504
47triglyceride homeostasis (GO:0070328)4.63504888
48acylglycerol homeostasis (GO:0055090)4.63504888
49homocysteine metabolic process (GO:0050667)4.54478806
50S-adenosylmethionine metabolic process (GO:0046500)4.51917976
51alkaloid metabolic process (GO:0009820)4.49466489
52alpha-amino acid catabolic process (GO:1901606)4.48776343
53indolalkylamine metabolic process (GO:0006586)4.42350288
54coenzyme catabolic process (GO:0009109)4.42329922
55plasma lipoprotein particle clearance (GO:0034381)4.40312091
56negative regulation of sterol transport (GO:0032372)4.39987808
57negative regulation of cholesterol transport (GO:0032375)4.39987808
58negative regulation of complement activation (GO:0045916)4.34648689
59bile acid and bile salt transport (GO:0015721)4.32606863
60amino-acid betaine metabolic process (GO:0006577)4.31659406
61cholesterol efflux (GO:0033344)4.31655392
62lysine catabolic process (GO:0006554)4.29316645
63lysine metabolic process (GO:0006553)4.29316645
64cellular ketone body metabolic process (GO:0046950)4.25791500
65regulation of plasminogen activation (GO:0010755)4.25627960
66amine catabolic process (GO:0009310)4.25180212
67cellular biogenic amine catabolic process (GO:0042402)4.25180212
68regulation of humoral immune response (GO:0002920)4.20280127
69imidazole-containing compound metabolic process (GO:0052803)4.16048023
70fibrinolysis (GO:0042730)4.12877102
71cellular amino acid catabolic process (GO:0009063)4.10562771
72ethanol metabolic process (GO:0006067)4.09282437
73glutamate metabolic process (GO:0006536)4.08101052
74plasma lipoprotein particle assembly (GO:0034377)4.06637006
75negative regulation of blood coagulation (GO:0030195)4.06574203
76negative regulation of hemostasis (GO:1900047)4.06574203
77glycine metabolic process (GO:0006544)4.04800651
78benzene-containing compound metabolic process (GO:0042537)4.04143874
79flavonoid metabolic process (GO:0009812)4.03520119
80blood coagulation, intrinsic pathway (GO:0007597)3.99088488
81cellular glucuronidation (GO:0052695)3.97013729
82acute-phase response (GO:0006953)3.94007376
83cellular modified amino acid catabolic process (GO:0042219)3.93585945
84serine family amino acid metabolic process (GO:0009069)3.88383148
85low-density lipoprotein particle remodeling (GO:0034374)3.87990213
86negative regulation of protein activation cascade (GO:2000258)3.86640624
87opsonization (GO:0008228)3.86034183
88complement activation, classical pathway (GO:0006958)3.85438098
89arginine metabolic process (GO:0006525)3.85073688
90negative regulation of lipase activity (GO:0060192)3.84610933
91dicarboxylic acid biosynthetic process (GO:0043650)3.84128661
92protein activation cascade (GO:0072376)3.83756326
93positive regulation of triglyceride lipase activity (GO:0061365)3.82668095
94positive regulation of lipoprotein lipase activity (GO:0051006)3.82668095
95drug catabolic process (GO:0042737)3.82262709
96very-low-density lipoprotein particle assembly (GO:0034379)3.81120168
97cofactor catabolic process (GO:0051187)3.80691805
98heme transport (GO:0015886)3.78949406
99aldehyde catabolic process (GO:0046185)3.77828289
100complement activation (GO:0006956)3.77019308
101cytolysis (GO:0019835)3.74895385
102negative regulation of wound healing (GO:0061045)3.72858511
103regulation of bile acid biosynthetic process (GO:0070857)3.71761257
104negative regulation of coagulation (GO:0050819)3.71567691
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71117500
106cholesterol homeostasis (GO:0042632)3.68104876
107ketone body metabolic process (GO:1902224)3.68072219
108phospholipid homeostasis (GO:0055091)3.67667722
109plasma lipoprotein particle organization (GO:0071827)3.67350880
110ethanol oxidation (GO:0006069)3.66408907
111serine family amino acid biosynthetic process (GO:0009070)3.65721192
112intestinal cholesterol absorption (GO:0030299)3.63420749
113regulation of cholesterol homeostasis (GO:2000188)3.63028462
114positive regulation of lipid catabolic process (GO:0050996)3.62819872
115sterol homeostasis (GO:0055092)3.62222982
116protein-lipid complex assembly (GO:0065005)3.60224224
117organic acid catabolic process (GO:0016054)3.59427874
118carboxylic acid catabolic process (GO:0046395)3.59427874
119short-chain fatty acid metabolic process (GO:0046459)3.54892258
120glucuronate metabolic process (GO:0019585)3.54168880
121L-methionine salvage (GO:0071267)3.51936086
122L-methionine biosynthetic process (GO:0071265)3.51936086
123amino acid salvage (GO:0043102)3.51936086
124xenobiotic metabolic process (GO:0006805)3.45670329
125hormone catabolic process (GO:0042447)3.43001148
126positive regulation of hemostasis (GO:1900048)3.39070468
127positive regulation of blood coagulation (GO:0030194)3.39070468
128steroid catabolic process (GO:0006706)3.36376457
129xenobiotic catabolic process (GO:0042178)3.34817045
130drug transmembrane transport (GO:0006855)3.34674799
131killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.34421005
132disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.34421005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.06299543
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92654073
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.83579022
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28929328
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21659665
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12951841
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22110642
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04001468
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99757602
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69719759
11GBX2_23144817_ChIP-Seq_PC3_Human2.68593962
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30427711
13IGF1R_20145208_ChIP-Seq_DFB_Human2.21960692
14ZNF274_21170338_ChIP-Seq_K562_Hela2.08289205
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03379267
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5770941
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93102170
18VDR_22108803_ChIP-Seq_LS180_Human1.87939150
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86969730
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.80255992
21* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75821602
22ER_23166858_ChIP-Seq_MCF-7_Human1.71590979
23HTT_18923047_ChIP-ChIP_STHdh_Human1.71450087
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.64728213
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64338964
26GATA1_22025678_ChIP-Seq_K562_Human1.58968863
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53485377
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53301113
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47419560
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42797282
31P300_19829295_ChIP-Seq_ESCs_Human1.39266397
32STAT3_23295773_ChIP-Seq_U87_Human1.38563445
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36453427
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31972538
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31775085
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31452971
37CBP_20019798_ChIP-Seq_JUKART_Human1.31452971
38SOX2_19829295_ChIP-Seq_ESCs_Human1.26263461
39NANOG_19829295_ChIP-Seq_ESCs_Human1.26263461
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24500588
41TCF4_23295773_ChIP-Seq_U87_Human1.24311836
42CLOCK_20551151_ChIP-Seq_293T_Human1.23974429
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23493836
44FUS_26573619_Chip-Seq_HEK293_Human1.22182670
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21173197
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.21035377
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18736877
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17627042
49TCF4_22108803_ChIP-Seq_LS180_Human1.17347357
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16990314
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.16484130
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15996160
53AR_25329375_ChIP-Seq_VCAP_Human1.14457455
54P53_22387025_ChIP-Seq_ESCs_Mouse1.13333545
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.11630734
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11426697
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.11426697
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11413090
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10107809
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09821327
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09808394
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08388563
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.08134203
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08127125
65P300_18555785_Chip-Seq_ESCs_Mouse1.07720276
66PHF8_20622853_ChIP-Seq_HELA_Human1.07583915
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.06750296
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06705300
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06285926
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05881480
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05788250
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05266763
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.04464216
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.01492331
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.01161037
76RUNX2_22187159_ChIP-Seq_PCA_Human1.01144095
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.00394032
78NFYA_21822215_ChIP-Seq_K562_Human1.00063759
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98927775
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98739615
81ETV1_20927104_ChIP-Seq_GIST48_Human0.98334575
82CMYC_18555785_Chip-Seq_ESCs_Mouse0.98107982
83SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97405686
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96565002
85CTCF_18555785_Chip-Seq_ESCs_Mouse0.94634958
86SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94337147
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90511786
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89732903
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88430636
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80478151
91GATA4_25053715_ChIP-Seq_YYC3_Human0.78663137
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78551531
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77652909
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76973697
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76138305
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74529606
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72813572
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72813572
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.72795895
100TAF15_26573619_Chip-Seq_HEK293_Human0.69283181
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69039245
102RARA_24833708_ChIP-Seq_LIVER_Mouse0.67843585
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.65928446
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65248739
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64967233
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64914197
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64814426
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.64167359
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63961681
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61064421
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60686803
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60559006
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.60343116
114* AR_20517297_ChIP-Seq_VCAP_Human0.58349844
115IRF1_19129219_ChIP-ChIP_H3396_Human0.57777995
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56962749
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.56869252
118CBP_21632823_ChIP-Seq_H3396_Human0.55796643
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55699973
120BCAT_22108803_ChIP-Seq_LS180_Human0.55359397
121STAT1_17558387_ChIP-Seq_HELA_Human0.53146278
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.51976936
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.51853397
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51772107
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.51649275
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.51113549
127* MYC_19915707_ChIP-ChIP_AK7_Human0.50649969
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.50524532
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.50248782
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.49855859
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.49715766
132CEBPB_22108803_ChIP-Seq_LS180_Human0.49537062
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.48882941
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48621280
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48487115
136* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47183770
137EGR1_19032775_ChIP-ChIP_M12_Human0.47126774
138P53_21459846_ChIP-Seq_SAOS-2_Human0.46847995
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.46532286
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.46415737
141GATA1_19941826_ChIP-Seq_K562_Human0.44600316
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44292554
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43955033
144NCOR_22424771_ChIP-Seq_293T_Human0.43497883
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.43353684
146CDX2_22108803_ChIP-Seq_LS180_Human0.43270624
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.42572644
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.42446687
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42154159
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.41965328
151ERG_20517297_ChIP-Seq_VCAP_Human0.41735137
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.41477865
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.40911121
154TAF2_19829295_ChIP-Seq_ESCs_Human0.40174385
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40158383
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.39009949
157LXR_22292898_ChIP-Seq_THP-1_Human0.38992438
158PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38166746
159SOX2_20726797_ChIP-Seq_SW620_Human0.37494601
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.37058048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.26409378
2MP0005360_urolithiasis7.32410692
3MP0005085_abnormal_gallbladder_physiolo6.38532972
4MP0005365_abnormal_bile_salt6.28520653
5MP0008875_abnormal_xenobiotic_pharmacok4.91714651
6MP0003806_abnormal_nucleotide_metabolis3.99645588
7MP0003252_abnormal_bile_duct3.92080176
8MP0010329_abnormal_lipoprotein_level3.53805477
9MP0003195_calcinosis3.24391323
10MP0009840_abnormal_foam_cell3.20163008
11MP0005083_abnormal_biliary_tract3.17041574
12MP0005332_abnormal_amino_acid2.71500654
13MP0001666_abnormal_nutrient_absorption2.66550621
14MP0003191_abnormal_cellular_cholesterol2.43054205
15MP0000609_abnormal_liver_physiology2.14282021
16MP0002118_abnormal_lipid_homeostasis2.13208101
17MP0003868_abnormal_feces_composition2.13145310
18MP0002138_abnormal_hepatobiliary_system2.13079580
19MP0004019_abnormal_vitamin_homeostasis2.12730869
20MP0005319_abnormal_enzyme/_coenzyme1.71859141
21MP0001764_abnormal_homeostasis1.63295806
22MP0009697_abnormal_copulation1.58408842
23MP0005584_abnormal_enzyme/coenzyme_acti1.46813195
24MP0005451_abnormal_body_composition1.36199134
25MP0003011_delayed_dark_adaptation1.32911588
26MP0009643_abnormal_urine_homeostasis1.31510117
27MP0003656_abnormal_erythrocyte_physiolo1.11671750
28MP0005647_abnormal_sex_gland1.10617958
29MP0000598_abnormal_liver_morphology1.10535530
30MP0005551_abnormal_eye_electrophysiolog1.09277159
31MP0003186_abnormal_redox_activity1.08755704
32MP0005636_abnormal_mineral_homeostasis1.07674504
33MP0005187_abnormal_penis_morphology1.07484167
34MP0000604_amyloidosis1.06317606
35MP0005220_abnormal_exocrine_pancreas1.03332610
36MP0002254_reproductive_system_inflammat1.00290067
37MP0002876_abnormal_thyroid_physiology0.99018680
38MP0009764_decreased_sensitivity_to0.98521087
39MP0002078_abnormal_glucose_homeostasis0.98053263
40MP0005084_abnormal_gallbladder_morpholo0.96180685
41MP0002638_abnormal_pupillary_reflex0.95615510
42* MP0009763_increased_sensitivity_to0.94772234
43MP0010368_abnormal_lymphatic_system0.94223242
44MP0005646_abnormal_pituitary_gland0.93477750
45MP0005408_hypopigmentation0.91662685
46* MP0009642_abnormal_blood_homeostasis0.91399324
47MP0010386_abnormal_urinary_bladder0.91246412
48MP0005670_abnormal_white_adipose0.89817949
49MP0008469_abnormal_protein_level0.88013437
50MP0002909_abnormal_adrenal_gland0.87607175
51MP0005645_abnormal_hypothalamus_physiol0.85049825
52MP0001661_extended_life_span0.84566426
53MP0003705_abnormal_hypodermis_morpholog0.81527214
54MP0009765_abnormal_xenobiotic_induced0.78413538
55MP0004142_abnormal_muscle_tone0.77090534
56MP0005535_abnormal_body_temperature0.77052429
57MP0005376_homeostasis/metabolism_phenot0.74789223
58MP0006036_abnormal_mitochondrial_physio0.73312765
59MP0002132_abnormal_respiratory_system0.72798879
60MP0000639_abnormal_adrenal_gland0.72182369
61MP0005334_abnormal_fat_pad0.71945630
62MP0002971_abnormal_brown_adipose0.71866607
63MP0001501_abnormal_sleep_pattern0.70818276
64MP0009046_muscle_twitch0.70297296
65MP0003690_abnormal_glial_cell0.68990733
66MP0001756_abnormal_urination0.66770993
67MP0002837_dystrophic_cardiac_calcinosis0.65059880
68MP0003879_abnormal_hair_cell0.64963196
69MP0005448_abnormal_energy_balance0.62102469
70MP0001944_abnormal_pancreas_morphology0.61128048
71MP0009745_abnormal_behavioral_response0.60308769
72MP0002928_abnormal_bile_duct0.58503697
73MP0003329_amyloid_beta_deposits0.58076351
74MP0000569_abnormal_digit_pigmentation0.57644743
75MP0001984_abnormal_olfaction0.57146038
76MP0001986_abnormal_taste_sensitivity0.57047924
77MP0004130_abnormal_muscle_cell0.56129021
78MP0005266_abnormal_metabolism0.55540671
79MP0008877_abnormal_DNA_methylation0.55517938
80MP0006292_abnormal_olfactory_placode0.55513783
81MP0005167_abnormal_blood-brain_barrier0.55222075
82MP0003953_abnormal_hormone_level0.55121535
83MP0003633_abnormal_nervous_system0.52969048
84MP0003122_maternal_imprinting0.52827939
85MP0002282_abnormal_trachea_morphology0.52625305
86MP0002090_abnormal_vision0.52061018
87MP0005464_abnormal_platelet_physiology0.51892615
88MP0005253_abnormal_eye_physiology0.51348041
89MP0000579_abnormal_nail_morphology0.50557088
90MP0005379_endocrine/exocrine_gland_phen0.50323034
91MP0005395_other_phenotype0.49671052
92MP0006276_abnormal_autonomic_nervous0.49278309
93MP0004043_abnormal_pH_regulation0.48982888
94MP0004381_abnormal_hair_follicle0.47835505
95MP0001324_abnormal_eye_pigmentation0.47249829
96MP0003724_increased_susceptibility_to0.46776332
97MP0003638_abnormal_response/metabolism_0.46166962
98MP0009053_abnormal_anal_canal0.45807580
99MP0003646_muscle_fatigue0.45565165
100MP0002693_abnormal_pancreas_physiology0.44478386
101MP0002102_abnormal_ear_morphology0.43636643
102MP0002136_abnormal_kidney_physiology0.43259800
103MP0002938_white_spotting0.42660434
104MP0002822_catalepsy0.42120343
105MP0005248_abnormal_Harderian_gland0.41922976
106MP0006072_abnormal_retinal_apoptosis0.41170151
107MP0006035_abnormal_mitochondrial_morpho0.41136719
108MP0005386_behavior/neurological_phenoty0.41098760
109MP0004924_abnormal_behavior0.41098760
110MP0003631_nervous_system_phenotype0.40409364
111MP0003632_abnormal_nervous_system0.40279427
112MP0008874_decreased_physiological_sensi0.39955857
113MP0000371_diluted_coat_color0.39579585
114MP0004782_abnormal_surfactant_physiolog0.39228059
115MP0003718_maternal_effect0.38572110
116MP0004264_abnormal_extraembryonic_tissu0.38015368
117MP0000230_abnormal_systemic_arterial0.37746323
118MP0009384_cardiac_valve_regurgitation0.36340572
119MP0008873_increased_physiological_sensi0.35991216
120MP0009672_abnormal_birth_weight0.34737993
121MP0002168_other_aberrant_phenotype0.33721442
122MP0000427_abnormal_hair_cycle0.33165273
123MP0005666_abnormal_adipose_tissue0.32763869
124MP0003959_abnormal_lean_body0.31925650
125MP0001765_abnormal_ion_homeostasis0.31860091
126MP0003436_decreased_susceptibility_to0.31524021
127MP0003075_altered_response_to0.29944360
128MP0001881_abnormal_mammary_gland0.29469274
129MP0002970_abnormal_white_adipose0.29073370
130MP0005166_decreased_susceptibility_to0.27445636
131MP0000249_abnormal_blood_vessel0.25802334
132MP0009780_abnormal_chondrocyte_physiolo0.25451861
133MP0001243_abnormal_dermal_layer0.25344884
134MP0009115_abnormal_fat_cell0.24692738
135MP0008872_abnormal_physiological_respon0.24606073

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47475951
2Deep venous thrombosis (HP:0002625)7.26659865
3Intrahepatic cholestasis (HP:0001406)7.24826640
4Prolonged partial thromboplastin time (HP:0003645)6.91606416
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54710054
6Hypobetalipoproteinemia (HP:0003563)6.13903644
7Xanthomatosis (HP:0000991)6.13293503
8Complement deficiency (HP:0004431)5.60441456
9Hyperlipoproteinemia (HP:0010980)5.46328504
10Joint hemorrhage (HP:0005261)5.04236778
11Abnormality of the common coagulation pathway (HP:0010990)4.96917182
12Hypolipoproteinemia (HP:0010981)4.65576846
13Epidermoid cyst (HP:0200040)4.44695402
14Hypoglycemic coma (HP:0001325)4.39505191
15Ketosis (HP:0001946)4.31239073
16Hyperammonemia (HP:0001987)4.30805843
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26457668
18Hyperglycinemia (HP:0002154)4.18099036
19Fat malabsorption (HP:0002630)4.17589880
20Hypoalphalipoproteinemia (HP:0003233)4.13512498
21Abnormality of the intrinsic pathway (HP:0010989)4.12317826
22Conjugated hyperbilirubinemia (HP:0002908)4.10769673
23Abnormality of methionine metabolism (HP:0010901)4.10217712
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.06690146
25Abnormality of complement system (HP:0005339)4.03075115
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95747429
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94652843
28Abnormality of pyrimidine metabolism (HP:0004353)3.66747674
29Abnormality of glycine metabolism (HP:0010895)3.63776184
30Abnormality of serine family amino acid metabolism (HP:0010894)3.63776184
31Hyperglycinuria (HP:0003108)3.62829818
32Spontaneous abortion (HP:0005268)3.55242749
33Hypercholesterolemia (HP:0003124)3.43884008
34Ketoacidosis (HP:0001993)3.34177043
35Hyperbilirubinemia (HP:0002904)3.31522665
36Hypoglycemic seizures (HP:0002173)3.30338829
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22843865
38Abnormality of fatty-acid metabolism (HP:0004359)3.11978621
39Fair hair (HP:0002286)3.10454048
40Nephritis (HP:0000123)3.08981988
41Steatorrhea (HP:0002570)3.07646436
42Hypochromic microcytic anemia (HP:0004840)2.98893168
43Hyperinsulinemic hypoglycemia (HP:0000825)2.98278046
44Abnormality of nucleobase metabolism (HP:0010932)2.95700214
45Skin nodule (HP:0200036)2.88080515
46Abnormality of serum amino acid levels (HP:0003112)2.87098052
47Delayed CNS myelination (HP:0002188)2.85708406
48Myocardial infarction (HP:0001658)2.84753375
49Hepatocellular carcinoma (HP:0001402)2.83931373
50Systemic lupus erythematosus (HP:0002725)2.71675196
51Metabolic acidosis (HP:0001942)2.67749424
52Bile duct proliferation (HP:0001408)2.65930456
53Abnormal biliary tract physiology (HP:0012439)2.65930456
54Abnormality of purine metabolism (HP:0004352)2.60176484
55Amyloidosis (HP:0011034)2.56835036
56Glomerulonephritis (HP:0000099)2.54063989
57Hypothermia (HP:0002045)2.53177381
58Acanthocytosis (HP:0001927)2.53031216
59Arthropathy (HP:0003040)2.52724428
60Osteomalacia (HP:0002749)2.52322907
61Gingival bleeding (HP:0000225)2.51618645
62Late onset (HP:0003584)2.50289736
63Vascular calcification (HP:0004934)2.48966666
64Lethargy (HP:0001254)2.48278401
65Mitral stenosis (HP:0001718)2.46688594
66Abnormal gallbladder morphology (HP:0012437)2.45835124
67Recurrent gram-negative bacterial infections (HP:0005420)2.45340356
68Dicarboxylic aciduria (HP:0003215)2.43613092
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43613092
70Reduced antithrombin III activity (HP:0001976)2.42976788
71Irritability (HP:0000737)2.39406240
72Hyperventilation (HP:0002883)2.39380291
73Gout (HP:0001997)2.38524064
74Symptomatic seizures (HP:0011145)2.34281478
75Cerebral edema (HP:0002181)2.33941051
76Hyperglycemia (HP:0003074)2.33443264
77Enlarged kidneys (HP:0000105)2.31636734
78Menorrhagia (HP:0000132)2.28914320
79Cholelithiasis (HP:0001081)2.27907839
80Generalized hypopigmentation of hair (HP:0011358)2.26736851
81Abnormality of vitamin metabolism (HP:0100508)2.20643806
82Neonatal onset (HP:0003623)2.19166309
83Pancreatitis (HP:0001733)2.18255555
84Cardiovascular calcification (HP:0011915)2.17524552
85Spastic diplegia (HP:0001264)2.16211022
86Abnormality of alanine metabolism (HP:0010916)2.16191465
87Hyperalaninemia (HP:0003348)2.16191465
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16191465
89Thrombophlebitis (HP:0004418)2.15882256
90Hyperphosphaturia (HP:0003109)2.15636796
91Brushfield spots (HP:0001088)2.14285046
92Generalized aminoaciduria (HP:0002909)2.12452202
93Abnormal gallbladder physiology (HP:0012438)2.11272405
94Cholecystitis (HP:0001082)2.11272405
95Sensorimotor neuropathy (HP:0007141)2.07422680
96Opisthotonus (HP:0002179)2.07145733
97Pulmonary embolism (HP:0002204)2.04759151
98Renal cortical cysts (HP:0000803)2.03964628
99Malnutrition (HP:0004395)2.03792512
100Esophageal varix (HP:0002040)2.02566621
101Vomiting (HP:0002013)1.99069955
102Hypophosphatemic rickets (HP:0004912)1.98458095
103Abnormality of the gallbladder (HP:0005264)1.97766375
104Rickets (HP:0002748)1.96618862
105Abnormality of endocrine pancreas physiology (HP:0012093)1.94758871
106Abnormality of the pancreatic islet cells (HP:0006476)1.94758871
107Poikilocytosis (HP:0004447)1.93051207
108Abnormality of transition element cation homeostasis (HP:0011030)1.92317959
109Abnormality of iron homeostasis (HP:0011031)1.92059949
110Alkalosis (HP:0001948)1.91734911
111Hemorrhage of the eye (HP:0011885)1.90427563
112Chronic hepatic failure (HP:0100626)1.89153993
113Abnormal enzyme/coenzyme activity (HP:0012379)1.88016519
114Abnormality of the renal cortex (HP:0011035)1.87281098
115Hydroxyprolinuria (HP:0003080)1.81660534
116Abnormality of proline metabolism (HP:0010907)1.81660534
117Elevated hepatic transaminases (HP:0002910)1.78684763
118Acute hepatic failure (HP:0006554)1.77303725
119Potter facies (HP:0002009)1.77156790
120Facial shape deformation (HP:0011334)1.77156790
121Proximal tubulopathy (HP:0000114)1.76338009
122Pancreatic cysts (HP:0001737)1.75311104
123Abnormality of urine glucose concentration (HP:0011016)1.74458734
124Glycosuria (HP:0003076)1.74458734
125Joint swelling (HP:0001386)1.71861752
126Blue irides (HP:0000635)1.60915480
127Cerebral palsy (HP:0100021)1.58222646
128Abnormal urine phosphate concentration (HP:0012599)1.57555029
129Congenital stationary night blindness (HP:0007642)1.54589629
130Gangrene (HP:0100758)1.50552391
131Attenuation of retinal blood vessels (HP:0007843)1.48086154
132Neoplasm of the liver (HP:0002896)1.47302782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.12947413
2INSRR4.85147458
3ERN14.61111183
4FGFR44.38195849
5TAOK34.22401498
6SIK14.01021089
7ERBB43.06898426
8BMPR1B2.81592303
9ADRBK22.80570225
10ACVR1B2.56080612
11MAP4K22.49536211
12PIK3CG2.16095783
13MAP2K42.06683877
14CASK2.01986405
15MAPK152.01168209
16NTRK31.99211079
17NUAK11.94693111
18MST1R1.89328654
19FRK1.86596076
20ZAK1.77853729
21FLT31.71301381
22MAPK111.69679898
23DAPK21.63439620
24MAP3K41.53696922
25LATS11.51881287
26PTK61.43284241
27EPHA31.41851148
28CAMKK21.36677576
29TYK21.29367787
30BRSK21.23108272
31JAK21.18743071
32PRKAA21.17429349
33MAPK131.16500696
34EPHB11.15325230
35FGFR21.15161435
36OXSR11.14533945
37EIF2AK31.14178404
38PRKCE1.12015934
39ABL21.10144434
40TRIB31.07065161
41PINK11.03412023
42MST41.02989285
43MET1.01125379
44IRAK31.01055460
45ERBB21.00359401
46JAK10.99747708
47MAP3K70.98961621
48PKN20.97447257
49STK390.97100305
50GRK10.96224639
51MAP3K140.94685552
52MAP3K120.94153514
53NEK90.92959883
54KDR0.92891122
55PDK20.88042740
56TLK10.87439280
57PKN10.84586746
58PRKCZ0.81546624
59MKNK20.81528989
60IRAK10.79475238
61CAMK2G0.79444820
62PRKACG0.79021270
63ADRBK10.78954801
64DYRK1B0.78245301
65CSNK1D0.77766850
66PHKG10.76355230
67PHKG20.76355230
68TXK0.76129932
69TNK20.75873920
70ERBB30.75611877
71CAMK1D0.75113084
72MAPK40.70691204
73GSK3A0.70443443
74TIE10.68802388
75PRKAA10.68608164
76STK38L0.68542872
77PTK20.68282386
78TBK10.67859497
79PRKG10.67545581
80MAP3K130.65657644
81MAP3K30.65162959
82STK30.64688829
83MAP3K10.64419416
84GRK60.62034518
85MAP3K20.61638398
86MAPK70.61332494
87TRPM70.61181036
88BCR0.61120501
89CSNK1A10.59051331
90MAP2K70.58745985
91CSK0.58325826
92MUSK0.57258768
93MAPKAPK30.55832394
94MAPK120.55114895
95TEC0.55022251
96FGFR30.53697287
97TRIM280.53359959
98TNIK0.51834125
99CSNK1G10.50931359
100AKT30.50510656
101SGK30.50230382
102PRKCQ0.50123703
103PDPK10.48866381
104SGK20.48653041
105SGK2230.47602936
106SGK4940.47602936
107PAK30.47281130
108MAP2K30.47092968
109IGF1R0.46175388
110IRAK20.45927601
111PRKCG0.44779827
112CSNK1E0.44725660
113WNK30.44563480
114CAMK1G0.43716351
115MAP2K60.43609390
116IKBKE0.43518538
117PRKACB0.42082577
118PRKCB0.41620969
119SGK10.40965296
120STK110.40860961
121PTK2B0.40664576
122MAP2K20.40373292
123MAP2K10.39509100
124WNK40.39317045
125PLK20.39239983
126ICK0.39129689
127NLK0.38828766
128DYRK20.38718119
129CAMK2A0.38290926
130PIK3CA0.38286876
131CDK60.37505518
132MAP3K100.36968304
133STK160.36942581
134PDK10.36932097
135ITK0.36640704
136RET0.36481526
137EPHA40.36056715
138PRKCH0.33744367
139MTOR0.33008075
140PRKCA0.31810106
141CHUK0.31289803
142CSNK1G20.30457365
143PRKCI0.30295983
144RPS6KA30.30280799
145OBSCN0.30101057
146CSNK1A1L0.29944089
147PRKACA0.28729508
148NTRK10.28027345
149CSNK1G30.28007770
150FER0.27208202
151MAP3K110.26233885
152CAMK40.26059943
153EGFR0.24088141
154MAP3K60.23757732

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.52651653
2Nitrogen metabolism_Homo sapiens_hsa009103.54836231
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24494334
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19828270
5Arginine biosynthesis_Homo sapiens_hsa002203.02163976
6Complement and coagulation cascades_Homo sapiens_hsa046102.98325721
7Tryptophan metabolism_Homo sapiens_hsa003802.74472379
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59484926
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53503200
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47362368
11Fatty acid degradation_Homo sapiens_hsa000712.39520156
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35517684
13Butanoate metabolism_Homo sapiens_hsa006502.17660164
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14744140
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14618991
16Peroxisome_Homo sapiens_hsa041462.07284620
17Histidine metabolism_Homo sapiens_hsa003401.95850625
18Chemical carcinogenesis_Homo sapiens_hsa052041.91392254
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.90684147
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.87819680
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86623925
22Staphylococcus aureus infection_Homo sapiens_hsa051501.85279544
23Propanoate metabolism_Homo sapiens_hsa006401.81820513
24PPAR signaling pathway_Homo sapiens_hsa033201.80528602
25Fatty acid metabolism_Homo sapiens_hsa012121.72591906
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70704607
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.69983016
28beta-Alanine metabolism_Homo sapiens_hsa004101.67764335
29Caffeine metabolism_Homo sapiens_hsa002321.67404849
30Retinol metabolism_Homo sapiens_hsa008301.62831824
31Selenocompound metabolism_Homo sapiens_hsa004501.62267680
32Phenylalanine metabolism_Homo sapiens_hsa003601.61221383
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60817840
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60172842
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58760206
36Sulfur metabolism_Homo sapiens_hsa009201.57025726
37Tyrosine metabolism_Homo sapiens_hsa003501.49284706
38Bile secretion_Homo sapiens_hsa049761.45754188
39Fatty acid elongation_Homo sapiens_hsa000621.36581936
40ABC transporters_Homo sapiens_hsa020101.32572241
41Folate biosynthesis_Homo sapiens_hsa007901.30092114
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29062554
43Steroid biosynthesis_Homo sapiens_hsa001001.27221185
44Fat digestion and absorption_Homo sapiens_hsa049751.26951359
45Pyruvate metabolism_Homo sapiens_hsa006201.25762436
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24203119
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.19054879
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09699365
49Biosynthesis of amino acids_Homo sapiens_hsa012301.02844127
50Arginine and proline metabolism_Homo sapiens_hsa003300.98446711
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97401864
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96078310
53Carbon metabolism_Homo sapiens_hsa012000.94946920
54Vitamin digestion and absorption_Homo sapiens_hsa049770.91823726
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86563604
56Sulfur relay system_Homo sapiens_hsa041220.84854365
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.83741302
58Lysine degradation_Homo sapiens_hsa003100.81082259
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74110327
60One carbon pool by folate_Homo sapiens_hsa006700.69075669
61Glycerolipid metabolism_Homo sapiens_hsa005610.63608143
62Glutathione metabolism_Homo sapiens_hsa004800.61823115
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57309839
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54647030
65Prion diseases_Homo sapiens_hsa050200.49219778
66Metabolic pathways_Homo sapiens_hsa011000.47081563
67Fatty acid biosynthesis_Homo sapiens_hsa000610.44551001
68Pentose phosphate pathway_Homo sapiens_hsa000300.41945953
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38665010
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37144492
71Linoleic acid metabolism_Homo sapiens_hsa005910.34080933
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29935867
73Serotonergic synapse_Homo sapiens_hsa047260.27447525
74Insulin resistance_Homo sapiens_hsa049310.27038250
75Galactose metabolism_Homo sapiens_hsa000520.25841465
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24887654
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21326795
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.18211850
79Fructose and mannose metabolism_Homo sapiens_hsa000510.17897478
80Glucagon signaling pathway_Homo sapiens_hsa049220.16805113
81Pertussis_Homo sapiens_hsa051330.15255119
82Phototransduction_Homo sapiens_hsa047440.14466409
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11271881
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11188707
85Circadian rhythm_Homo sapiens_hsa047100.10234843
86Mineral absorption_Homo sapiens_hsa049780.10090828
87Protein export_Homo sapiens_hsa030600.04883949
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04089121
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02525203
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02477363
91AMPK signaling pathway_Homo sapiens_hsa041520.02247612
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2180318
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1897527
94Lysosome_Homo sapiens_hsa04142-0.1750873
95Hepatitis C_Homo sapiens_hsa05160-0.1744227
96African trypanosomiasis_Homo sapiens_hsa05143-0.1449978
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1422535
98Ether lipid metabolism_Homo sapiens_hsa00565-0.1366029
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1263706
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1126883
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1076861
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0948053
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0914306
104Type II diabetes mellitus_Homo sapiens_hsa04930-0.0890874
105GABAergic synapse_Homo sapiens_hsa04727-0.0714998
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0628177
107Oxidative phosphorylation_Homo sapiens_hsa00190-0.0510387
108Nicotine addiction_Homo sapiens_hsa05033-0.0383643
109Regulation of autophagy_Homo sapiens_hsa04140-0.0269844
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0196047
111Sphingolipid metabolism_Homo sapiens_hsa00600-0.0143141
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0060444
113Insulin secretion_Homo sapiens_hsa04911-0.0051022
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0022856

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