SERINC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22792050
2synaptic vesicle exocytosis (GO:0016079)5.17638767
3vocalization behavior (GO:0071625)5.00828572
4neuron cell-cell adhesion (GO:0007158)4.94617746
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84894825
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74919764
7glutamate secretion (GO:0014047)4.69889179
8regulation of synaptic vesicle exocytosis (GO:2000300)4.69453144
9synaptic vesicle maturation (GO:0016188)4.52763784
10protein localization to synapse (GO:0035418)4.51638304
11neuronal action potential propagation (GO:0019227)4.47334390
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45027914
13locomotory exploration behavior (GO:0035641)4.43098125
14regulation of glutamate receptor signaling pathway (GO:1900449)4.39303378
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.25714347
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.25218178
17presynaptic membrane assembly (GO:0097105)4.18960026
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.16276546
19regulation of synaptic vesicle transport (GO:1902803)4.10679830
20neurotransmitter-gated ion channel clustering (GO:0072578)4.09770621
21gamma-aminobutyric acid signaling pathway (GO:0007214)4.05706694
22glutamate receptor signaling pathway (GO:0007215)4.04220951
23neurotransmitter secretion (GO:0007269)4.02509920
24neuron-neuron synaptic transmission (GO:0007270)3.98183299
25presynaptic membrane organization (GO:0097090)3.97755873
26synaptic transmission, glutamatergic (GO:0035249)3.88223555
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.81916269
28pyrimidine nucleobase catabolic process (GO:0006208)3.81752076
29exploration behavior (GO:0035640)3.77475840
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73540114
31sodium ion export (GO:0071436)3.72360561
32neuron recognition (GO:0008038)3.68211549
33regulation of neuronal synaptic plasticity (GO:0048168)3.67302269
34gamma-aminobutyric acid transport (GO:0015812)3.63834352
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56856955
36long-term synaptic potentiation (GO:0060291)3.56159639
37postsynaptic membrane organization (GO:0001941)3.52553264
38neurotransmitter transport (GO:0006836)3.43021431
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42254711
40regulation of postsynaptic membrane potential (GO:0060078)3.41762029
41cerebellar granule cell differentiation (GO:0021707)3.40427657
42transmission of nerve impulse (GO:0019226)3.38705177
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.33308453
44synaptic vesicle endocytosis (GO:0048488)3.32344159
45positive regulation of synapse maturation (GO:0090129)3.32301140
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30175879
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30003493
48positive regulation of membrane potential (GO:0045838)3.29809167
49layer formation in cerebral cortex (GO:0021819)3.29438129
50long-term memory (GO:0007616)3.27910148
51axonal fasciculation (GO:0007413)3.25428670
52nucleobase catabolic process (GO:0046113)3.25133005
53regulation of synapse structural plasticity (GO:0051823)3.24848559
54cellular potassium ion homeostasis (GO:0030007)3.22715901
55proline transport (GO:0015824)3.22382404
56regulation of synaptic plasticity (GO:0048167)3.21718900
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21527121
58regulation of neurotransmitter secretion (GO:0046928)3.21171006
59response to histamine (GO:0034776)3.20463016
60neuronal ion channel clustering (GO:0045161)3.19230994
61dendritic spine morphogenesis (GO:0060997)3.16599659
62regulation of neurotransmitter levels (GO:0001505)3.13274527
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13095280
64regulation of glutamate secretion (GO:0014048)3.10831452
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10566787
66regulation of vesicle fusion (GO:0031338)3.09506392
67negative regulation of neurotransmitter transport (GO:0051589)3.07236982
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07096350
69behavioral response to cocaine (GO:0048148)3.05507580
70regulation of dendritic spine morphogenesis (GO:0061001)3.02588485
71activation of protein kinase A activity (GO:0034199)3.01642048
72synapse assembly (GO:0007416)2.98169416
73regulation of neurotransmitter transport (GO:0051588)2.97763409
74startle response (GO:0001964)2.97598872
75cell communication by electrical coupling (GO:0010644)2.95973014
76positive regulation of synapse assembly (GO:0051965)2.93836711
77membrane depolarization (GO:0051899)2.93504250
78dendrite morphogenesis (GO:0048813)2.91794749
79positive regulation of neurotransmitter secretion (GO:0001956)2.91112934
80cerebellar Purkinje cell differentiation (GO:0021702)2.90454742
81establishment of mitochondrion localization (GO:0051654)2.90025042
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89623166
83amino acid import (GO:0043090)2.88147890
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.87797440
85ATP hydrolysis coupled proton transport (GO:0015991)2.87797440
86auditory behavior (GO:0031223)2.87579281
87detection of calcium ion (GO:0005513)2.86208363
88synaptic transmission (GO:0007268)2.85407932
89positive regulation of synaptic transmission (GO:0050806)2.85072079
90regulation of voltage-gated calcium channel activity (GO:1901385)2.84852852
91L-amino acid import (GO:0043092)2.84230789
92learning (GO:0007612)2.84090063
93behavioral defense response (GO:0002209)2.83905038
94behavioral fear response (GO:0001662)2.83905038
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83482971
96mating behavior (GO:0007617)2.81673284
97positive regulation of neurotransmitter transport (GO:0051590)2.80874938
98regulation of synaptic transmission (GO:0050804)2.80554139
99mechanosensory behavior (GO:0007638)2.79939860
100acidic amino acid transport (GO:0015800)2.79485711
101membrane hyperpolarization (GO:0060081)2.79126790
102fear response (GO:0042596)2.79074895
103cellular sodium ion homeostasis (GO:0006883)2.78551435
104vesicle transport along microtubule (GO:0047496)2.78215355
105synapse organization (GO:0050808)2.77884902
106synaptic vesicle transport (GO:0048489)2.76873819
107establishment of synaptic vesicle localization (GO:0097480)2.76873819
108regulation of female receptivity (GO:0045924)2.76525922
109neuromuscular process controlling posture (GO:0050884)2.76342382
110response to auditory stimulus (GO:0010996)2.75727194
111adult walking behavior (GO:0007628)2.74413197
112female mating behavior (GO:0060180)2.74388822
113nerve growth factor signaling pathway (GO:0038180)2.71287414
114glycosphingolipid biosynthetic process (GO:0006688)2.66868071
115response to dietary excess (GO:0002021)2.65942731
116potassium ion import (GO:0010107)2.63895374
117potassium ion homeostasis (GO:0055075)2.63165265
118dendritic spine organization (GO:0097061)2.62323911
119organelle transport along microtubule (GO:0072384)2.58110844
120neurotransmitter uptake (GO:0001504)2.57203293
121membrane depolarization during action potential (GO:0086010)2.56897830
122regulation of dendritic spine development (GO:0060998)2.56893046
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56142288
124regulation of cAMP-dependent protein kinase activity (GO:2000479)2.55182158
125positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53470259
126cell communication involved in cardiac conduction (GO:0086065)2.53357618
127positive regulation of dendritic spine development (GO:0060999)2.52386072
128establishment of vesicle localization (GO:0051650)2.50361021
129neuromuscular synaptic transmission (GO:0007274)2.47516519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09662557
2GBX2_23144817_ChIP-Seq_PC3_Human4.09885437
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09640006
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03463299
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87120960
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59715154
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53276946
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53276946
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49890747
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46986224
11REST_21632747_ChIP-Seq_MESCs_Mouse2.45917737
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43018274
13TAF15_26573619_Chip-Seq_HEK293_Human2.42375709
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39662962
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38368747
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37083044
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32522082
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.11846920
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10040695
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03465097
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.02536274
22DROSHA_22980978_ChIP-Seq_HELA_Human2.01052910
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.00865447
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.97965563
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95765762
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94715927
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94640406
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91653760
29AR_21572438_ChIP-Seq_LNCaP_Human1.87349528
30SMAD4_21799915_ChIP-Seq_A2780_Human1.80571964
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77612459
32P300_19829295_ChIP-Seq_ESCs_Human1.69994580
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69718871
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64403733
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64188818
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62922462
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61016160
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59885380
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58797826
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55068469
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.49352157
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.48087967
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48018141
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45201034
45* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44055274
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43066061
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42691213
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40702115
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.39860077
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37947311
51AR_25329375_ChIP-Seq_VCAP_Human1.37655389
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.37022901
53ZNF274_21170338_ChIP-Seq_K562_Hela1.36956399
54FUS_26573619_Chip-Seq_HEK293_Human1.36125322
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.35728355
56VDR_22108803_ChIP-Seq_LS180_Human1.35075055
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34954843
58STAT3_23295773_ChIP-Seq_U87_Human1.31089013
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28582156
60IGF1R_20145208_ChIP-Seq_DFB_Human1.27649639
61ER_23166858_ChIP-Seq_MCF-7_Human1.24476097
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.22926655
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22058186
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21791261
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.21696347
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19603765
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17852344
68TCF4_23295773_ChIP-Seq_U87_Human1.16846815
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.15361115
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14372381
71* RNF2_27304074_Chip-Seq_NSC_Mouse1.14131715
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.11792729
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.09783233
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09501620
75RUNX2_22187159_ChIP-Seq_PCA_Human1.09177032
76AR_19668381_ChIP-Seq_PC3_Human1.08622259
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08401070
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08056767
79AHR_22903824_ChIP-Seq_MCF-7_Human1.07119219
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.06098331
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05727463
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05603936
83JUN_21703547_ChIP-Seq_K562_Human1.04309693
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03465953
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03073415
86TP53_16413492_ChIP-PET_HCT116_Human1.02354657
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01753189
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.01721548
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.01702755
90TP53_18474530_ChIP-ChIP_U2OS_Human1.01544634
91P53_22387025_ChIP-Seq_ESCs_Mouse1.00949090
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00798133
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99357292
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98682712
95WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97930277
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97663344
97BCAT_22108803_ChIP-Seq_LS180_Human0.96748266
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.96684753
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96684137
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93789083
101TAL1_26923725_Chip-Seq_HPCs_Mouse0.93546385
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93492125
103* FLI1_21867929_ChIP-Seq_TH2_Mouse0.92507460
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91796374
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91735518
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91735518
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91003160
108E2F1_18555785_Chip-Seq_ESCs_Mouse0.90905345
109CBP_20019798_ChIP-Seq_JUKART_Human0.90904600
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90904600
111KDM2B_26808549_Chip-Seq_REH_Human0.90685531
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89834663
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.88779744
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.88264885
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87877622
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.86780883
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.86674960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.36382248
2MP0003880_abnormal_central_pattern5.22128083
3MP0003635_abnormal_synaptic_transmissio3.89636890
4MP0004270_analgesia3.51478017
5MP0009745_abnormal_behavioral_response3.37826486
6MP0002064_seizures3.21171642
7MP0002063_abnormal_learning/memory/cond3.15208552
8MP0009046_muscle_twitch3.13830113
9MP0001968_abnormal_touch/_nociception3.06501304
10MP0002572_abnormal_emotion/affect_behav2.76928877
11MP0002272_abnormal_nervous_system2.71225995
12MP0002734_abnormal_mechanical_nocicepti2.63975351
13MP0002736_abnormal_nociception_after2.61124220
14MP0001486_abnormal_startle_reflex2.44687606
15MP0005423_abnormal_somatic_nervous2.36160788
16MP0002822_catalepsy2.35829182
17MP0001501_abnormal_sleep_pattern2.33384134
18MP0002735_abnormal_chemical_nociception2.31883564
19MP0001440_abnormal_grooming_behavior2.31028814
20MP0009780_abnormal_chondrocyte_physiolo2.22378686
21MP0003329_amyloid_beta_deposits2.10546547
22MP0002067_abnormal_sensory_capabilities2.09876145
23MP0002733_abnormal_thermal_nociception1.97954874
24MP0006276_abnormal_autonomic_nervous1.96800801
25MP0001970_abnormal_pain_threshold1.94871455
26MP0001529_abnormal_vocalization1.84929937
27MP0004924_abnormal_behavior1.83021465
28MP0005386_behavior/neurological_phenoty1.83021465
29MP0000778_abnormal_nervous_system1.80335541
30MP0002184_abnormal_innervation1.71857165
31MP0008569_lethality_at_weaning1.69061821
32MP0005646_abnormal_pituitary_gland1.68306170
33MP0000569_abnormal_digit_pigmentation1.61689100
34MP0002557_abnormal_social/conspecific_i1.61312229
35MP0001905_abnormal_dopamine_level1.61149114
36MP0001984_abnormal_olfaction1.59344875
37MP0002837_dystrophic_cardiac_calcinosis1.58020260
38MP0002909_abnormal_adrenal_gland1.53868759
39MP0004142_abnormal_muscle_tone1.48786041
40MP0004811_abnormal_neuron_physiology1.47701878
41MP0000955_abnormal_spinal_cord1.46730353
42MP0003879_abnormal_hair_cell1.44942602
43MP0002066_abnormal_motor_capabilities/c1.41299862
44MP0004858_abnormal_nervous_system1.38981951
45MP0002882_abnormal_neuron_morphology1.36158096
46MP0003633_abnormal_nervous_system1.36129992
47MP0004885_abnormal_endolymph1.33254740
48MP0003122_maternal_imprinting1.30724900
49MP0001502_abnormal_circadian_rhythm1.29411012
50MP0003787_abnormal_imprinting1.26841796
51MP0005645_abnormal_hypothalamus_physiol1.26135229
52MP0000013_abnormal_adipose_tissue1.25884334
53MP0010386_abnormal_urinary_bladder1.23809447
54MP0000920_abnormal_myelination1.21289975
55MP0003631_nervous_system_phenotype1.20148937
56MP0002102_abnormal_ear_morphology1.17838742
57MP0001188_hyperpigmentation1.16791868
58MP0005551_abnormal_eye_electrophysiolog1.13977924
59MP0002229_neurodegeneration1.11357208
60MP0002876_abnormal_thyroid_physiology1.10596721
61MP0000751_myopathy1.09614550
62MP0004742_abnormal_vestibular_system1.09499798
63MP0004145_abnormal_muscle_electrophysio1.09370456
64MP0003690_abnormal_glial_cell1.05518650
65MP0000604_amyloidosis1.04180395
66MP0003634_abnormal_glial_cell1.01238616
67MP0002152_abnormal_brain_morphology0.98745419
68MP0003121_genomic_imprinting0.97491314
69MP0003632_abnormal_nervous_system0.94016509
70MP0005535_abnormal_body_temperature0.92449855
71MP0005171_absent_coat_pigmentation0.91022286
72MP0002069_abnormal_eating/drinking_beha0.90115878
73MP0001963_abnormal_hearing_physiology0.90074671
74MP0004043_abnormal_pH_regulation0.87562154
75MP0001986_abnormal_taste_sensitivity0.86504242
76MP0004085_abnormal_heartbeat0.85653443
77MP0008872_abnormal_physiological_respon0.84023064
78MP0001177_atelectasis0.82817602
79MP0008874_decreased_physiological_sensi0.82474385
80MP0002090_abnormal_vision0.82010253
81MP0004215_abnormal_myocardial_fiber0.79804435
82MP0005167_abnormal_blood-brain_barrier0.79775205
83MP0002752_abnormal_somatic_nervous0.77607251
84MP0004484_altered_response_of0.77550455
85MP0005187_abnormal_penis_morphology0.75665362
86MP0002295_abnormal_pulmonary_circulatio0.75265623
87MP0000631_abnormal_neuroendocrine_gland0.74919361
88MP0001664_abnormal_digestion0.71128760
89MP0005623_abnormal_meninges_morphology0.71116987
90MP0000639_abnormal_adrenal_gland0.69582488
91MP0003172_abnormal_lysosome_physiology0.69243306
92MP0001485_abnormal_pinna_reflex0.67870666
93MP0001958_emphysema0.67146787
94MP0002332_abnormal_exercise_endurance0.66177966
95MP0005253_abnormal_eye_physiology0.65702084
96MP0003183_abnormal_peptide_metabolism0.65682544
97MP0004147_increased_porphyrin_level0.63777897
98MP0001299_abnormal_eye_distance/0.63402525
99MP0002638_abnormal_pupillary_reflex0.62211219
100MP0004510_myositis0.59120925
101MP0001943_abnormal_respiration0.58166874
102MP0004036_abnormal_muscle_relaxation0.58025188
103MP0005394_taste/olfaction_phenotype0.57864126
104MP0005499_abnormal_olfactory_system0.57864126
105MP0005409_darkened_coat_color0.55434099
106MP0004233_abnormal_muscle_weight0.54887723
107MP0003075_altered_response_to0.53637770
108MP0000026_abnormal_inner_ear0.53291455
109MP0002971_abnormal_brown_adipose0.52986016
110MP0003137_abnormal_impulse_conducting0.52431377
111MP0006072_abnormal_retinal_apoptosis0.52395005
112MP0008438_abnormal_cutaneous_collagen0.51859889
113MP0002133_abnormal_respiratory_system0.51442696
114MP0005388_respiratory_system_phenotype0.51442696
115MP0000747_muscle_weakness0.49813589
116MP0005379_endocrine/exocrine_gland_phen0.47414860
117MP0004130_abnormal_muscle_cell0.47307174
118MP0003283_abnormal_digestive_organ0.46787872

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.61297909
2Focal seizures (HP:0007359)5.31679234
3Myokymia (HP:0002411)5.30780603
4Atonic seizures (HP:0010819)5.25836420
5Epileptic encephalopathy (HP:0200134)5.09746204
6Visual hallucinations (HP:0002367)4.75641793
7Absence seizures (HP:0002121)4.33871650
8Febrile seizures (HP:0002373)4.32072399
9Hyperventilation (HP:0002883)4.31199587
10Dialeptic seizures (HP:0011146)4.06396070
11Generalized tonic-clonic seizures (HP:0002069)3.81120674
12Progressive cerebellar ataxia (HP:0002073)3.78188421
13Broad-based gait (HP:0002136)3.56711420
14Cerebral inclusion bodies (HP:0100314)3.43863297
15Neurofibrillary tangles (HP:0002185)3.42212524
16Supranuclear gaze palsy (HP:0000605)3.40998810
17Action tremor (HP:0002345)3.23752079
18Pheochromocytoma (HP:0002666)3.18723626
19Gaze-evoked nystagmus (HP:0000640)3.07997376
20Truncal ataxia (HP:0002078)3.05785344
21Dysmetria (HP:0001310)3.01680466
22Insidious onset (HP:0003587)2.99451363
23Termporal pattern (HP:0011008)2.99451363
24Ankle clonus (HP:0011448)2.98201891
25Dysdiadochokinesis (HP:0002075)2.97019384
26Poor eye contact (HP:0000817)2.94976933
27Abnormality of the corticospinal tract (HP:0002492)2.90787023
28Impaired vibration sensation in the lower limbs (HP:0002166)2.88798131
29Amblyopia (HP:0000646)2.87029012
30Neuroendocrine neoplasm (HP:0100634)2.86069474
31Anxiety (HP:0000739)2.83890357
32Amyotrophic lateral sclerosis (HP:0007354)2.82404291
33Scanning speech (HP:0002168)2.80934582
34Abnormal eating behavior (HP:0100738)2.80802226
35Drooling (HP:0002307)2.80571191
36Excessive salivation (HP:0003781)2.80571191
37Depression (HP:0000716)2.78495626
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76565237
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.76565237
40Epileptiform EEG discharges (HP:0011182)2.74199033
41Progressive inability to walk (HP:0002505)2.72607214
42Abnormal social behavior (HP:0012433)2.69600558
43Impaired social interactions (HP:0000735)2.69600558
44Diplopia (HP:0000651)2.64297996
45Abnormality of binocular vision (HP:0011514)2.64297996
46Hemiplegia (HP:0002301)2.60480156
47Spastic gait (HP:0002064)2.60120440
48Urinary bladder sphincter dysfunction (HP:0002839)2.57579525
49EEG with generalized epileptiform discharges (HP:0011198)2.55926570
50Fetal akinesia sequence (HP:0001989)2.43216582
51Limb dystonia (HP:0002451)2.41657413
52Peripheral hypomyelination (HP:0007182)2.41046487
53Hemiparesis (HP:0001269)2.40236018
54Mutism (HP:0002300)2.40131378
55Polyphagia (HP:0002591)2.39271906
56Postural instability (HP:0002172)2.36645436
57Hypsarrhythmia (HP:0002521)2.36598009
58Urinary urgency (HP:0000012)2.35929791
59Absent speech (HP:0001344)2.35914670
60Intention tremor (HP:0002080)2.32832375
61Blue irides (HP:0000635)2.31321779
62Inability to walk (HP:0002540)2.30584892
63Gait imbalance (HP:0002141)2.29157030
64Spastic tetraplegia (HP:0002510)2.24993777
65Lower limb muscle weakness (HP:0007340)2.21807343
66Generalized myoclonic seizures (HP:0002123)2.21745711
67Apathy (HP:0000741)2.19555129
68Akinesia (HP:0002304)2.18039073
69Hammertoe (HP:0001765)2.17484570
70Bradykinesia (HP:0002067)2.17181312
71Clonus (HP:0002169)2.09756141
72Impaired smooth pursuit (HP:0007772)2.09672441
73Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08651434
74Rapidly progressive (HP:0003678)2.08273882
75Diminished motivation (HP:0000745)2.06588878
76Ulnar claw (HP:0001178)2.06438911
77Morphological abnormality of the pyramidal tract (HP:0002062)2.05183754
78Protruding tongue (HP:0010808)2.04668969
79Papillary thyroid carcinoma (HP:0002895)2.04480977
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03149918
81Torticollis (HP:0000473)2.03144728
82Status epilepticus (HP:0002133)2.02192983
83Neuronal loss in central nervous system (HP:0002529)2.00810800
84Delusions (HP:0000746)2.00699357
85Gait ataxia (HP:0002066)2.00400673
86Agitation (HP:0000713)1.99467101
87Abnormal hair whorl (HP:0010721)1.97426393
88Impaired vibratory sensation (HP:0002495)1.97358793
89Genetic anticipation (HP:0003743)1.95539887
90Psychosis (HP:0000709)1.95123645
91Congenital primary aphakia (HP:0007707)1.94743418
92Dysmetric saccades (HP:0000641)1.93786755
93Retinal dysplasia (HP:0007973)1.92505494
94Abnormality of salivation (HP:0100755)1.92211213
95Stereotypic behavior (HP:0000733)1.92125671
96Split foot (HP:0001839)1.90904671
97Focal dystonia (HP:0004373)1.90874288
98Medial flaring of the eyebrow (HP:0010747)1.90106795
99Hyperthyroidism (HP:0000836)1.89664131
100Sleep apnea (HP:0010535)1.88718776
101Abnormality of the lower motor neuron (HP:0002366)1.88440157
102Paraplegia (HP:0010550)1.87570672
103Tetraplegia (HP:0002445)1.87394503
104Papilledema (HP:0001085)1.87370631
105Specific learning disability (HP:0001328)1.86807862
106Thickened helices (HP:0000391)1.86456687
107Hypoplasia of the corpus callosum (HP:0002079)1.86363401
108Resting tremor (HP:0002322)1.85288684
109Failure to thrive in infancy (HP:0001531)1.85226005
110Abnormality of ocular smooth pursuit (HP:0000617)1.83297763
111Hypoventilation (HP:0002791)1.80203286
112Megalencephaly (HP:0001355)1.79617974
113Increased circulating renin level (HP:0000848)1.79083068
114Craniofacial dystonia (HP:0012179)1.78873598
115Sensory axonal neuropathy (HP:0003390)1.78088932
116Postural tremor (HP:0002174)1.77877840
117Clumsiness (HP:0002312)1.77751617
118Nephrogenic diabetes insipidus (HP:0009806)1.76350721
119Mitral stenosis (HP:0001718)1.75801734
120Acute necrotizing encephalopathy (HP:0006965)1.75679971
121Neoplasm of the peripheral nervous system (HP:0100007)1.74811436
122Rigidity (HP:0002063)1.74651965
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.73787731
124Inappropriate behavior (HP:0000719)1.73543145
125Spastic paraplegia (HP:0001258)1.73068813
126Hand muscle atrophy (HP:0009130)1.71458237
127Spastic tetraparesis (HP:0001285)1.71250330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.06269614
2EPHA43.92803453
3CASK3.70646696
4MAP3K43.11398573
5MAP3K93.00481614
6MAP2K72.77260442
7MAP3K122.59031253
8MARK12.57553646
9MINK12.29958266
10DAPK22.22479826
11PLK22.03143374
12MAP2K42.01445821
13RIPK41.96227671
14CDK191.94096959
15NTRK11.89860120
16OXSR11.81240484
17EPHA31.76268334
18PNCK1.76108839
19PAK61.75484489
20KSR21.69973391
21NTRK21.69759922
22GRK51.60967800
23ERBB31.50872837
24TNIK1.50732135
25ARAF1.47171289
26PRPF4B1.46256116
27CDK51.41700791
28DAPK11.38628550
29KSR11.33164463
30CAMKK21.31005664
31MAPK131.24763461
32CAMKK11.22543611
33CAMK2A1.20616093
34PRKCG1.20274602
35TRIM281.20139305
36STK391.16644655
37CAMK2B1.14636475
38SGK4941.10730327
39SGK2231.10730327
40UHMK11.06347128
41MAP3K21.04627006
42BMPR21.03847991
43RIPK11.03059569
44MAP3K131.00371163
45PTK2B1.00095933
46FES0.98422148
47PRKD30.96255430
48MAP4K20.92655430
49BCR0.90238956
50FGR0.88203468
51AKT30.87749958
52CDK140.87667089
53CDK180.86827782
54PHKG10.86257116
55PHKG20.86257116
56PRKCE0.84330430
57CSNK1G20.84181649
58CSNK1A1L0.83784124
59CDK150.83585354
60PAK30.82019250
61LIMK10.81869942
62CAMK2D0.81427366
63NME10.80710868
64SIK20.79146193
65SIK30.78054084
66TESK10.77132829
67CCNB10.77049966
68TYRO30.75551620
69SGK20.71258504
70DYRK1A0.70725942
71CDK11A0.70044487
72PRKCH0.68147139
73RET0.67911291
74CSNK1G10.66928340
75MAPKAPK50.66749688
76STK110.65780395
77CAMK2G0.65444059
78SGK10.64855288
79CAMK40.64732923
80STK380.64508673
81GRK70.63694478
82DYRK20.62915828
83ROCK20.61411881
84WNK10.60798537
85FER0.60329919
86RAF10.60113516
87PKN10.59691637
88CAMK10.58877966
89WNK40.58869560
90JAK10.58132932
91FGFR20.57283123
92DYRK1B0.56398727
93PDPK10.56317960
94MAP3K60.56009216
95LMTK20.53688519
96NEK60.53653715
97EPHB10.53534636
98MAPK100.52899969
99WNK30.51174860
100MAP3K10.50807375
101DDR20.50076655
102FRK0.48304045
103PINK10.48032337
104LATS20.47886345
105MAPK120.47435982
106PDK10.46615093
107MAP2K10.46563191
108SGK30.46029079
109YES10.45778028
110PDK40.45772012
111PDK30.45772012
112MUSK0.45736127
113ADRBK10.45178579
114PDGFRA0.44929065
115JAK20.44143434
116MARK20.43882511
117FYN0.43720794
118CSNK1G30.43179825
119MAP3K50.42681189
120ADRBK20.41463689
121BRAF0.40829352
122PRKG10.40374735
123PRKCZ0.40240587
124DAPK30.39692672
125PRKAA10.39636204
126TNK20.39420623
127RPS6KA30.38921349
128MOS0.38531498

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88866836
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44019150
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78789581
4GABAergic synapse_Homo sapiens_hsa047272.72850082
5Circadian entrainment_Homo sapiens_hsa047132.50825641
6Long-term potentiation_Homo sapiens_hsa047202.47848147
7Morphine addiction_Homo sapiens_hsa050322.47615696
8Collecting duct acid secretion_Homo sapiens_hsa049662.45718472
9Glutamatergic synapse_Homo sapiens_hsa047242.42954703
10Olfactory transduction_Homo sapiens_hsa047402.36245392
11Amphetamine addiction_Homo sapiens_hsa050312.35193097
12Dopaminergic synapse_Homo sapiens_hsa047282.08209565
13Salivary secretion_Homo sapiens_hsa049702.01193895
14Taste transduction_Homo sapiens_hsa047421.94138957
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87264483
16Insulin secretion_Homo sapiens_hsa049111.85188242
17Serotonergic synapse_Homo sapiens_hsa047261.81752173
18Renin secretion_Homo sapiens_hsa049241.78078155
19Long-term depression_Homo sapiens_hsa047301.76019745
20Gastric acid secretion_Homo sapiens_hsa049711.68305778
21Cholinergic synapse_Homo sapiens_hsa047251.68190198
22Vibrio cholerae infection_Homo sapiens_hsa051101.61363107
23Cocaine addiction_Homo sapiens_hsa050301.56632231
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50697815
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47068383
26Calcium signaling pathway_Homo sapiens_hsa040201.46653062
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45439836
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42223248
29Oxidative phosphorylation_Homo sapiens_hsa001901.31949905
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23130165
31GnRH signaling pathway_Homo sapiens_hsa049121.20228470
32Gap junction_Homo sapiens_hsa045401.19651893
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17655863
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17235323
35Cardiac muscle contraction_Homo sapiens_hsa042601.14003043
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10333175
37Axon guidance_Homo sapiens_hsa043601.09940476
38cAMP signaling pathway_Homo sapiens_hsa040241.08259533
39Alzheimers disease_Homo sapiens_hsa050101.08173426
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05297364
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01848896
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98797181
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97421153
44Estrogen signaling pathway_Homo sapiens_hsa049150.96271310
45Type II diabetes mellitus_Homo sapiens_hsa049300.93920859
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93469207
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91908739
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90658256
49Phototransduction_Homo sapiens_hsa047440.90419553
50Parkinsons disease_Homo sapiens_hsa050120.85420251
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84980075
52Melanogenesis_Homo sapiens_hsa049160.83412921
53ErbB signaling pathway_Homo sapiens_hsa040120.83083373
54Glioma_Homo sapiens_hsa052140.80995941
55Pancreatic secretion_Homo sapiens_hsa049720.78186716
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75614838
57Regulation of autophagy_Homo sapiens_hsa041400.68598945
58Rheumatoid arthritis_Homo sapiens_hsa053230.68410655
59Thyroid hormone synthesis_Homo sapiens_hsa049180.67495654
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66750592
61Dilated cardiomyopathy_Homo sapiens_hsa054140.66242146
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65658826
63Dorso-ventral axis formation_Homo sapiens_hsa043200.62953246
64AMPK signaling pathway_Homo sapiens_hsa041520.60538759
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.60515704
66Butanoate metabolism_Homo sapiens_hsa006500.58174046
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57825081
68MAPK signaling pathway_Homo sapiens_hsa040100.55751046
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54830240
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54111899
71Oocyte meiosis_Homo sapiens_hsa041140.52665651
72Choline metabolism in cancer_Homo sapiens_hsa052310.52309796
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51820077
74Ras signaling pathway_Homo sapiens_hsa040140.51652234
75Type I diabetes mellitus_Homo sapiens_hsa049400.51489773
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51470719
77mTOR signaling pathway_Homo sapiens_hsa041500.50267603
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49634632
79Phagosome_Homo sapiens_hsa041450.49058200
80Glucagon signaling pathway_Homo sapiens_hsa049220.48470236
81Prion diseases_Homo sapiens_hsa050200.47740684
82Huntingtons disease_Homo sapiens_hsa050160.46687150
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.44083363
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43494861
85beta-Alanine metabolism_Homo sapiens_hsa004100.42754505
86Lysosome_Homo sapiens_hsa041420.42726893
87Circadian rhythm_Homo sapiens_hsa047100.42120601
88Fatty acid biosynthesis_Homo sapiens_hsa000610.41384069
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41093936
90PPAR signaling pathway_Homo sapiens_hsa033200.41002945
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40748676
92Inositol phosphate metabolism_Homo sapiens_hsa005620.40593141
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40294688
94Renal cell carcinoma_Homo sapiens_hsa052110.39771732
95Bile secretion_Homo sapiens_hsa049760.39764276
96Alcoholism_Homo sapiens_hsa050340.38934813
97Prolactin signaling pathway_Homo sapiens_hsa049170.38392903
98Insulin signaling pathway_Homo sapiens_hsa049100.38378653
99Salmonella infection_Homo sapiens_hsa051320.37349470
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37198628
101Protein digestion and absorption_Homo sapiens_hsa049740.37126951
102Ovarian steroidogenesis_Homo sapiens_hsa049130.37070016
103ABC transporters_Homo sapiens_hsa020100.36999935
104Mineral absorption_Homo sapiens_hsa049780.36825249
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36152542
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36149714
107Rap1 signaling pathway_Homo sapiens_hsa040150.35596483
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.34814544
109Endocytosis_Homo sapiens_hsa041440.34558668
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33565659
111African trypanosomiasis_Homo sapiens_hsa051430.32293920
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30494428
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29784041
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.29675813
115VEGF signaling pathway_Homo sapiens_hsa043700.29214897
116Ether lipid metabolism_Homo sapiens_hsa005650.28957416
117Fatty acid elongation_Homo sapiens_hsa000620.28535824
118Nitrogen metabolism_Homo sapiens_hsa009100.28335217
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26691680

Most similar genes based on co-expression Upload to Enrichr

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