SERHL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesoderm development (GO:2000380)7.45316060
2negative regulation of activin receptor signaling pathway (GO:0032926)6.28851637
3phospholipid scrambling (GO:0017121)6.26143214
4somite rostral/caudal axis specification (GO:0032525)6.20979285
5cell migration involved in gastrulation (GO:0042074)5.53082422
6endoderm formation (GO:0001706)5.19055357
7sequestering of extracellular ligand from receptor (GO:0035581)5.16393095
8primitive streak formation (GO:0090009)4.76500217
9DNA replication checkpoint (GO:0000076)4.42618025
10positive regulation of gastrulation (GO:2000543)4.42486777
11anterior/posterior axis specification (GO:0009948)4.40577351
12signal transduction involved in regulation of gene expression (GO:0023019)4.30833283
13regulation of activin receptor signaling pathway (GO:0032925)4.28024382
14DNA replication-dependent nucleosome organization (GO:0034723)4.24357125
15DNA replication-dependent nucleosome assembly (GO:0006335)4.24357125
16regulation of acrosome reaction (GO:0060046)4.16903988
17multicellular organism reproduction (GO:0032504)4.10692411
18nodal signaling pathway (GO:0038092)4.08329643
19meiotic chromosome segregation (GO:0045132)4.00371745
20piRNA metabolic process (GO:0034587)3.96029170
21embryonic axis specification (GO:0000578)3.85278395
22GDP-mannose metabolic process (GO:0019673)3.72218996
23DNA methylation involved in gamete generation (GO:0043046)3.71777193
24behavioral response to nicotine (GO:0035095)3.69822678
25embryonic pattern specification (GO:0009880)3.58797375
26DNA deamination (GO:0045006)3.54480686
27DNA strand renaturation (GO:0000733)3.49728829
28anterior/posterior axis specification, embryo (GO:0008595)3.41261686
29L-serine transport (GO:0015825)3.38764179
30regulation of female gonad development (GO:2000194)3.35740859
31CENP-A containing nucleosome assembly (GO:0034080)3.34501934
32chromatin remodeling at centromere (GO:0031055)3.25693696
33replication fork processing (GO:0031297)3.24250998
34DNA double-strand break processing (GO:0000729)3.21645332
35histone exchange (GO:0043486)3.16667643
36negative regulation of T cell differentiation in thymus (GO:0033085)3.14629409
37synapsis (GO:0007129)3.12119409
38cellular response to ATP (GO:0071318)3.03731709
39fat-soluble vitamin catabolic process (GO:0042363)3.02843758
40vitamin catabolic process (GO:0009111)3.02843758
41regulation of cytokine production involved in inflammatory response (GO:1900015)3.01536819
42preassembly of GPI anchor in ER membrane (GO:0016254)3.00985362
43keratinocyte development (GO:0003334)2.99816108
44nucleotide transmembrane transport (GO:1901679)2.99576577
45regulation of gastrulation (GO:0010470)2.94118230
46rRNA methylation (GO:0031167)2.93603785
47regulation of nuclear cell cycle DNA replication (GO:0033262)2.92636474
48gastrulation (GO:0007369)2.92565961
49regulation of female receptivity (GO:0045924)2.92095244
50purine nucleotide transport (GO:0015865)2.89949635
51extracellular regulation of signal transduction (GO:1900115)2.88314525
52extracellular negative regulation of signal transduction (GO:1900116)2.88314525
53mRNA cleavage (GO:0006379)2.87991479
54axis specification (GO:0009798)2.86180056
55response to BMP (GO:0071772)2.85759074
56cellular response to BMP stimulus (GO:0071773)2.85759074
57centriole replication (GO:0007099)2.84596545
58embryonic foregut morphogenesis (GO:0048617)2.82259606
59dorsal/ventral axis specification (GO:0009950)2.79071115
60urogenital system development (GO:0001655)2.77962561
61rRNA modification (GO:0000154)2.77092134
62oocyte development (GO:0048599)2.73769255
63meiotic cell cycle (GO:0051321)2.73667219
64epithelial cilium movement (GO:0003351)2.70028417
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69493486
66reciprocal DNA recombination (GO:0035825)2.68533574
67reciprocal meiotic recombination (GO:0007131)2.68533574
68positive regulation of protein kinase C signaling (GO:0090037)2.68409057
69resolution of meiotic recombination intermediates (GO:0000712)2.68180570
70negative regulation of reproductive process (GO:2000242)2.67567399
71heme transport (GO:0015886)2.66419880
72negative regulation of axon extension involved in axon guidance (GO:0048843)2.64710362
73base-excision repair, AP site formation (GO:0006285)2.64587727
74serine transport (GO:0032329)2.63226538
75gonadal mesoderm development (GO:0007506)2.61386934
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59734790
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59734790
78mannosylation (GO:0097502)2.55809039
79lung secretory cell differentiation (GO:0061140)2.55789885
80nucleotide transport (GO:0006862)2.55420660
81female mating behavior (GO:0060180)2.54702694
82dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53554661
83female gamete generation (GO:0007292)2.52346022
84kidney morphogenesis (GO:0060993)2.51309100
85interferon-gamma production (GO:0032609)2.50851586
86centriole assembly (GO:0098534)2.49942316
87detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.49893761
88genitalia morphogenesis (GO:0035112)2.49295229
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46904302
90female gonad development (GO:0008585)2.46835483
91GPI anchor metabolic process (GO:0006505)2.44422263
92gene silencing by RNA (GO:0031047)2.44253254
93positive regulation of catecholamine secretion (GO:0033605)2.44065915
94GPI anchor biosynthetic process (GO:0006506)2.43990072
95regulation of meiosis I (GO:0060631)2.43982915
96response to pheromone (GO:0019236)2.41615022
97regulation of skeletal muscle contraction (GO:0014819)2.40938682
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.38900638
99retinal cone cell development (GO:0046549)2.38552660
100sialylation (GO:0097503)2.37573576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.77270332
2EZH2_22144423_ChIP-Seq_EOC_Human3.26542969
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98548309
4ZNF274_21170338_ChIP-Seq_K562_Hela2.89412364
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.84556593
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.69530730
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65004217
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.53962089
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53438257
10VDR_22108803_ChIP-Seq_LS180_Human2.46724799
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.43426849
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.31692925
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27181719
14SMAD3_21741376_ChIP-Seq_HESCs_Human2.27127160
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26466402
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.07440811
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00444995
18EWS_26573619_Chip-Seq_HEK293_Human1.97230508
19* SMAD4_21741376_ChIP-Seq_HESCs_Human1.93181269
20MYC_18940864_ChIP-ChIP_HL60_Human1.89631808
21ERA_21632823_ChIP-Seq_H3396_Human1.84418139
22TP53_22573176_ChIP-Seq_HFKS_Human1.84203064
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78996027
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69248016
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.64973218
26VDR_23849224_ChIP-Seq_CD4+_Human1.63511552
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61801432
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59667228
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.58716720
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54340054
31SMAD4_21741376_ChIP-Seq_EPCs_Human1.53106985
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50467048
33FUS_26573619_Chip-Seq_HEK293_Human1.48679905
34EOMES_21245162_ChIP-Seq_HESCs_Human1.48150252
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47987735
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47337275
37NANOG_20526341_ChIP-Seq_ESCs_Human1.46970578
38DCP1A_22483619_ChIP-Seq_HELA_Human1.46561109
39BCAT_22108803_ChIP-Seq_LS180_Human1.46404057
40FOXP3_21729870_ChIP-Seq_TREG_Human1.46188913
41ER_23166858_ChIP-Seq_MCF-7_Human1.45108326
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43662431
43HOXB7_26014856_ChIP-Seq_BT474_Human1.42523729
44GABP_19822575_ChIP-Seq_HepG2_Human1.41951108
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.40723478
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34224598
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31077969
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31077969
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31077969
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.30035357
51P300_19829295_ChIP-Seq_ESCs_Human1.29469734
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28946568
53ELK1_19687146_ChIP-ChIP_HELA_Human1.25049741
54ELF5_23300383_ChIP-Seq_T47D_Human1.23145918
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22049922
56GBX2_23144817_ChIP-Seq_PC3_Human1.21342644
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.19612030
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18751532
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17678216
60CBP_20019798_ChIP-Seq_JUKART_Human1.17678216
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.16055444
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14153422
63NCOR_22424771_ChIP-Seq_293T_Human1.14126658
64IRF1_19129219_ChIP-ChIP_H3396_Human1.13604717
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13540370
66OCT4_20526341_ChIP-Seq_ESCs_Human1.08985910
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06920568
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05623883
69MYC_19829295_ChIP-Seq_ESCs_Human1.05409730
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.04243092
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03217008
72KDM5A_27292631_Chip-Seq_BREAST_Human1.02366073
73* P53_21459846_ChIP-Seq_SAOS-2_Human1.02135434
74RARB_24833708_ChIP-Seq_LIVER_Mouse1.00504829
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00356076
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00191062
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98462565
78TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98413718
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.96361416
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.96311283
81RNF2_27304074_Chip-Seq_NSC_Mouse0.95904341
82RUNX2_22187159_ChIP-Seq_PCA_Human0.95479622
83XRN2_22483619_ChIP-Seq_HELA_Human0.94254874
84E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93838972
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93059034
86TCF4_22108803_ChIP-Seq_LS180_Human0.92443667
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92429336
88AR_20517297_ChIP-Seq_VCAP_Human0.92408178
89BCL6_27268052_Chip-Seq_Bcells_Human0.92013940
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92012204
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92012204
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91814322
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.91814322
94NANOG_19829295_ChIP-Seq_ESCs_Human0.91685141
95SOX2_19829295_ChIP-Seq_ESCs_Human0.91685141
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91458804
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91138224
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90969224
99E2F1_20622854_ChIP-Seq_HELA_Human0.90293421
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89707909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.00574647
2MP0005394_taste/olfaction_phenotype3.67326749
3MP0005499_abnormal_olfactory_system3.67326749
4MP0003136_yellow_coat_color3.19106604
5MP0005423_abnormal_somatic_nervous2.98800610
6MP0001986_abnormal_taste_sensitivity2.75736488
7MP0003119_abnormal_digestive_system2.64610876
8MP0005174_abnormal_tail_pigmentation2.61382905
9MP0001968_abnormal_touch/_nociception2.42961051
10MP0010030_abnormal_orbit_morphology2.42811730
11MP0004133_heterotaxia2.31448048
12MP0008789_abnormal_olfactory_epithelium2.29788395
13MP0002736_abnormal_nociception_after2.25911978
14MP0008995_early_reproductive_senescence2.22798573
15MP0003195_calcinosis2.19102823
16MP0008877_abnormal_DNA_methylation2.06596613
17MP0001984_abnormal_olfaction2.02266753
18MP0006292_abnormal_olfactory_placode2.01869645
19MP0003718_maternal_effect2.00612161
20MP0008004_abnormal_stomach_pH1.98403955
21MP0002254_reproductive_system_inflammat1.90390999
22MP0005171_absent_coat_pigmentation1.89092461
23MP0008872_abnormal_physiological_respon1.61091999
24MP0001188_hyperpigmentation1.56790213
25MP0005551_abnormal_eye_electrophysiolog1.55589389
26MP0008875_abnormal_xenobiotic_pharmacok1.55369224
27MP0002638_abnormal_pupillary_reflex1.45563328
28MP0002938_white_spotting1.44336824
29MP0003880_abnormal_central_pattern1.41729876
30MP0002210_abnormal_sex_determination1.38096667
31MP0005083_abnormal_biliary_tract1.37818299
32MP0001929_abnormal_gametogenesis1.32148772
33MP0006072_abnormal_retinal_apoptosis1.31134487
34MP0003137_abnormal_impulse_conducting1.30076795
35MP0008058_abnormal_DNA_repair1.25862686
36MP0002160_abnormal_reproductive_system1.23262303
37MP0002102_abnormal_ear_morphology1.23172601
38MP0000372_irregular_coat_pigmentation1.22503250
39MP0010094_abnormal_chromosome_stability1.18874244
40MP0006276_abnormal_autonomic_nervous1.18760419
41MP0002277_abnormal_respiratory_mucosa1.16601182
42MP0000538_abnormal_urinary_bladder1.14981790
43MP0003693_abnormal_embryo_hatching1.14562745
44MP0005410_abnormal_fertilization1.11252872
45MP0000653_abnormal_sex_gland1.10787435
46MP0000427_abnormal_hair_cycle1.07241490
47MP0001485_abnormal_pinna_reflex1.06448388
48MP0002751_abnormal_autonomic_nervous1.05963834
49MP0003936_abnormal_reproductive_system1.04282537
50MP0001502_abnormal_circadian_rhythm1.02436556
51MP0008057_abnormal_DNA_replication1.02118150
52MP0002084_abnormal_developmental_patter1.00689317
53MP0001145_abnormal_male_reproductive0.96532787
54MP0001672_abnormal_embryogenesis/_devel0.96088617
55MP0005380_embryogenesis_phenotype0.96088617
56MP0003937_abnormal_limbs/digits/tail_de0.95876475
57MP0005646_abnormal_pituitary_gland0.92563745
58MP0003698_abnormal_male_reproductive0.92525380
59MP0002127_abnormal_cardiovascular_syste0.91114283
60MP0001119_abnormal_female_reproductive0.89600092
61MP0003786_premature_aging0.89592801
62MP0004264_abnormal_extraembryonic_tissu0.89043601
63MP0002111_abnormal_tail_morphology0.88962291
64MP0001293_anophthalmia0.88692568
65MP0002233_abnormal_nose_morphology0.86791660
66MP0002735_abnormal_chemical_nociception0.85908425
67MP0008932_abnormal_embryonic_tissue0.85418697
68MP0001286_abnormal_eye_development0.84329344
69MP0005253_abnormal_eye_physiology0.83908351
70MP0002653_abnormal_ependyma_morphology0.83249196
71MP0006054_spinal_hemorrhage0.82480177
72MP0004085_abnormal_heartbeat0.82381875
73MP0000470_abnormal_stomach_morphology0.80341978
74MP0000015_abnormal_ear_pigmentation0.80275358
75MP0001756_abnormal_urination0.80091202
76MP0003943_abnormal_hepatobiliary_system0.79197534
77MP0005389_reproductive_system_phenotype0.79133039
78MP0004043_abnormal_pH_regulation0.78975203
79MP0001529_abnormal_vocalization0.78490425
80MP0001919_abnormal_reproductive_system0.77468108
81MP0000049_abnormal_middle_ear0.76667049
82MP0002752_abnormal_somatic_nervous0.75567417
83MP0003699_abnormal_female_reproductive0.74274656
84MP0000631_abnormal_neuroendocrine_gland0.72800132
85MP0004381_abnormal_hair_follicle0.72502455
86MP0002234_abnormal_pharynx_morphology0.72091146
87MP0003385_abnormal_body_wall0.71409050
88MP0002161_abnormal_fertility/fecundity0.70880037
89MP0004145_abnormal_muscle_electrophysio0.69945547
90MP0001664_abnormal_digestion0.69158647
91MP0006035_abnormal_mitochondrial_morpho0.68975796
92MP0003935_abnormal_craniofacial_develop0.68490820
93MP0003077_abnormal_cell_cycle0.68429585
94MP0002282_abnormal_trachea_morphology0.68373129
95MP0004957_abnormal_blastocyst_morpholog0.67607679
96MP0005365_abnormal_bile_salt0.66991937
97MP0003755_abnormal_palate_morphology0.66777732
98MP0004084_abnormal_cardiac_muscle0.66752430
99MP0000026_abnormal_inner_ear0.66312809
100MP0004924_abnormal_behavior0.65922471

Predicted human phenotypes

RankGene SetZ-score
1Abdominal situs inversus (HP:0003363)3.85541907
2Abnormality of abdominal situs (HP:0011620)3.85541907
3Rectovaginal fistula (HP:0000143)3.74764221
4Rectal fistula (HP:0100590)3.74764221
5Rib fusion (HP:0000902)3.70528017
6Double outlet right ventricle (HP:0001719)3.36600432
7Congenital malformation of the right heart (HP:0011723)3.36600432
8Intestinal fistula (HP:0100819)3.36042326
9Vaginal fistula (HP:0004320)3.18288728
10Abnormal pancreas size (HP:0012094)3.10381744
11Birth length less than 3rd percentile (HP:0003561)2.97282942
12Attenuation of retinal blood vessels (HP:0007843)2.92721373
13Absent radius (HP:0003974)2.89528133
14Ependymoma (HP:0002888)2.87669157
15Septo-optic dysplasia (HP:0100842)2.84928516
16Bile duct proliferation (HP:0001408)2.79619598
17Abnormal biliary tract physiology (HP:0012439)2.79619598
18Absent forearm bone (HP:0003953)2.76931388
19Aplasia involving forearm bones (HP:0009822)2.76931388
20Oligodactyly (hands) (HP:0001180)2.68419292
21Hypoplasia of the pons (HP:0012110)2.61517413
22Abnormality of the pons (HP:0007361)2.60559610
23Concave nail (HP:0001598)2.59021939
24Congenital stationary night blindness (HP:0007642)2.58539771
25Molar tooth sign on MRI (HP:0002419)2.56197082
26Abnormality of midbrain morphology (HP:0002418)2.56197082
27Bony spicule pigmentary retinopathy (HP:0007737)2.51239398
28Anal stenosis (HP:0002025)2.47484356
29Patellar aplasia (HP:0006443)2.42369430
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39212368
31Testicular atrophy (HP:0000029)2.37738309
32Facial hemangioma (HP:0000329)2.36819033
33Hyperglycinuria (HP:0003108)2.36452542
34Abnormal umbilical cord blood vessels (HP:0011403)2.35703986
35Single umbilical artery (HP:0001195)2.35703986
36Abnormality of the fetal cardiovascular system (HP:0010948)2.35703986
37Stomach cancer (HP:0012126)2.34948748
38Methylmalonic acidemia (HP:0002912)2.34696244
39Absent thumb (HP:0009777)2.33359011
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.30910874
41Anophthalmia (HP:0000528)2.29840954
42Hypoplastic pelvis (HP:0008839)2.29823988
43Abnormality of the astrocytes (HP:0100707)2.28586003
44Astrocytoma (HP:0009592)2.28586003
45Nephronophthisis (HP:0000090)2.28269689
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27861689
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27793899
48Pancreatic cysts (HP:0001737)2.26253255
49Abnormality of the parathyroid morphology (HP:0011766)2.26013497
50Aplasia/Hypoplasia of the patella (HP:0006498)2.22778128
51Intestinal atresia (HP:0011100)2.22356402
52Abnormal drinking behavior (HP:0030082)2.17783806
53Polydipsia (HP:0001959)2.17783806
54Anteriorly placed anus (HP:0001545)2.16223052
55Progressive inability to walk (HP:0002505)2.15657131
56Short humerus (HP:0005792)2.14329383
57Aplasia/hypoplasia of the humerus (HP:0006507)2.14266065
58Gonadotropin excess (HP:0000837)2.14098941
59Pancreatic fibrosis (HP:0100732)2.11175139
60Asplenia (HP:0001746)2.10650339
61Optic nerve hypoplasia (HP:0000609)2.09944399
62Short thumb (HP:0009778)2.08741927
63Aplasia of the musculature (HP:0100854)2.07198419
64Glioma (HP:0009733)2.04446256
65Type I transferrin isoform profile (HP:0003642)2.03605051
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.00465367
67Hypoplasia of the fovea (HP:0007750)2.00465367
68Poikiloderma (HP:0001029)2.00141870
69Small hand (HP:0200055)1.98491038
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.97539877
71Type II lissencephaly (HP:0007260)1.97391528
72Chronic hepatic failure (HP:0100626)1.95874407
73Abnormality of the renal medulla (HP:0100957)1.94513388
74Decreased circulating renin level (HP:0003351)1.94351246
75Methylmalonic aciduria (HP:0012120)1.93499834
76Microretrognathia (HP:0000308)1.93416184
77Dyschromatopsia (HP:0007641)1.92740792
78Anencephaly (HP:0002323)1.92145185
79Increased number of teeth (HP:0011069)1.89518812
80Facial diplegia (HP:0001349)1.88910306
81Abnormality of the renal cortex (HP:0011035)1.86516161
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83845059
83Abnormal glycosylation (HP:0012345)1.83165912
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83165912
85Abnormal protein N-linked glycosylation (HP:0012347)1.83165912
86Abnormal protein glycosylation (HP:0012346)1.83165912
87Labial hypoplasia (HP:0000066)1.82344642
88Absent septum pellucidum (HP:0001331)1.82001889
89True hermaphroditism (HP:0010459)1.81731318
90Anal atresia (HP:0002023)1.81680498
91Gonadal dysgenesis (HP:0000133)1.79307692
92Chorioretinal atrophy (HP:0000533)1.77545887
93Inability to walk (HP:0002540)1.77288589
94Male pseudohermaphroditism (HP:0000037)1.76455304
95Polyuria (HP:0000103)1.76192659
96Tubular atrophy (HP:0000092)1.74507804
97Hypophosphatemic rickets (HP:0004912)1.73923988
98Bifid tongue (HP:0010297)1.73236334
99Abnormality of the fovea (HP:0000493)1.72778248
100Abnormality of glycine metabolism (HP:0010895)1.72474366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.66749104
2BMPR1B4.54175397
3TRIM283.65093617
4MST42.93663447
5ERBB42.92004840
6PKN22.87871241
7MAPK152.82556090
8WNK42.66298613
9ZAK2.58609751
10TLK12.46555232
11PBK2.37345280
12WNK32.31367685
13FRK2.00255729
14GRK11.96465244
15TGFBR11.93327318
16TNIK1.90207777
17PINK11.89161738
18MATK1.76281519
19STK391.73815892
20MUSK1.67267422
21NUAK11.65242919
22MAP3K41.64815122
23ADRBK21.59702104
24PRKCI1.55967334
25INSRR1.47736751
26MAP3K91.33914624
27MAPK131.32681342
28SIK31.30707149
29EPHA21.29635843
30MKNK21.25109210
31BRSK21.24347240
32ADRBK11.19796592
33PLK41.11621960
34MAP4K21.09177300
35WEE11.07602579
36OXSR11.02488274
37STK161.02461839
38TNK20.94445601
39NEK20.90163052
40CDK30.87649051
41CASK0.87399021
42NME10.85490430
43MAP2K70.83146213
44VRK10.80952424
45FLT30.75180639
46IRAK20.74892679
47PRKD30.70582057
48PLK10.69989010
49MELK0.66983593
50MAPKAPK30.65834064
51NTRK30.64066218
52TRIB30.62342715
53LRRK20.61314772
54TAOK30.60431548
55PNCK0.60234920
56ILK0.59562456
57CDC70.57082400
58CSNK1G10.56822405
59GRK60.54483565
60BCR0.53017818
61EIF2AK30.51144821
62STK100.51039604
63ARAF0.50659326
64ERBB20.50189491
65BRSK10.49687290
66VRK20.48531779
67NEK60.48429293
68PRKCQ0.47648816
69CHUK0.47374525
70ATR0.46066010
71CSNK1D0.45656352
72BCKDK0.45463957
73ERBB30.45372384
74CDK70.43798990
75CSNK1G30.42794023
76MARK30.42408055
77PLK20.42334561
78PLK30.42328635
79CSNK1G20.40757090
80MAP2K10.38960320
81FER0.38344384
82AURKA0.37825502
83SRPK10.36797535
84CDK180.36257468
85ROCK10.34852935
86CSNK1A10.34387955
87DAPK20.33975503
88PDK20.31476117
89CAMK1D0.29483637
90CSNK1A1L0.29226535
91NTRK20.29035792
92CSNK1E0.28053639
93CAMK1G0.27454369
94PRKG10.27356640
95CDK150.27326154
96TTK0.26942762
97PRKCE0.26920268
98MAP2K60.26871766
99SIK10.25863902
100ATM0.25228385

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.13641856
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.05057829
3Basal transcription factors_Homo sapiens_hsa030222.83444596
4Fanconi anemia pathway_Homo sapiens_hsa034602.75459396
5Butanoate metabolism_Homo sapiens_hsa006502.71075065
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52158185
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44553442
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40179769
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.31956018
10Homologous recombination_Homo sapiens_hsa034402.25019183
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02360406
12Sulfur relay system_Homo sapiens_hsa041221.99752997
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97844128
14ABC transporters_Homo sapiens_hsa020101.85533255
15Protein export_Homo sapiens_hsa030601.84059720
16RNA polymerase_Homo sapiens_hsa030201.82298063
17Proteasome_Homo sapiens_hsa030501.71379036
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66238342
19Steroid biosynthesis_Homo sapiens_hsa001001.63427554
20Propanoate metabolism_Homo sapiens_hsa006401.63210158
21RNA degradation_Homo sapiens_hsa030181.63098367
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52532372
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49131685
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47487481
25Olfactory transduction_Homo sapiens_hsa047401.45715711
26Phototransduction_Homo sapiens_hsa047441.45466267
27Caffeine metabolism_Homo sapiens_hsa002321.41205097
28Oxidative phosphorylation_Homo sapiens_hsa001901.37922409
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33172599
30Peroxisome_Homo sapiens_hsa041461.29557144
31Pyruvate metabolism_Homo sapiens_hsa006201.29281181
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26182512
33Mismatch repair_Homo sapiens_hsa034301.23394071
34Taste transduction_Homo sapiens_hsa047421.17547044
35Chemical carcinogenesis_Homo sapiens_hsa052041.15756522
36Base excision repair_Homo sapiens_hsa034101.15531645
37Fatty acid metabolism_Homo sapiens_hsa012121.14303523
38Ovarian steroidogenesis_Homo sapiens_hsa049131.14025246
39Parkinsons disease_Homo sapiens_hsa050121.12387493
40Circadian rhythm_Homo sapiens_hsa047101.10369843
41beta-Alanine metabolism_Homo sapiens_hsa004101.08424936
42Nicotine addiction_Homo sapiens_hsa050331.08314016
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07675415
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02389863
45Huntingtons disease_Homo sapiens_hsa050161.02132944
46TGF-beta signaling pathway_Homo sapiens_hsa043501.00181688
47Nitrogen metabolism_Homo sapiens_hsa009101.00083651
48RNA transport_Homo sapiens_hsa030130.99153735
49Basal cell carcinoma_Homo sapiens_hsa052170.98981794
50Hedgehog signaling pathway_Homo sapiens_hsa043400.98530298
51Vitamin digestion and absorption_Homo sapiens_hsa049770.98320782
52Non-homologous end-joining_Homo sapiens_hsa034500.96267681
53Wnt signaling pathway_Homo sapiens_hsa043100.92667258
54Hippo signaling pathway_Homo sapiens_hsa043900.91761692
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86931941
56Cell cycle_Homo sapiens_hsa041100.85756834
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84718710
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83608546
59Purine metabolism_Homo sapiens_hsa002300.81798290
60Tryptophan metabolism_Homo sapiens_hsa003800.81760056
61Fatty acid elongation_Homo sapiens_hsa000620.80414985
62Nucleotide excision repair_Homo sapiens_hsa034200.79827830
63Fatty acid degradation_Homo sapiens_hsa000710.78441535
64Histidine metabolism_Homo sapiens_hsa003400.75553329
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74041124
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73567608
67Sphingolipid metabolism_Homo sapiens_hsa006000.72200687
68Metabolic pathways_Homo sapiens_hsa011000.71519239
69N-Glycan biosynthesis_Homo sapiens_hsa005100.68264300
70Pyrimidine metabolism_Homo sapiens_hsa002400.68115965
71Calcium signaling pathway_Homo sapiens_hsa040200.66791200
72mRNA surveillance pathway_Homo sapiens_hsa030150.66670404
73Oocyte meiosis_Homo sapiens_hsa041140.62682137
74Linoleic acid metabolism_Homo sapiens_hsa005910.62437727
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.62430080
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62408310
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.59235456
78Lysine degradation_Homo sapiens_hsa003100.57178384
79Selenocompound metabolism_Homo sapiens_hsa004500.55190047
80Retinol metabolism_Homo sapiens_hsa008300.54972202
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54934860
82Glutathione metabolism_Homo sapiens_hsa004800.52875540
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51575756
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51192295
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49498765
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.48127164
87Regulation of autophagy_Homo sapiens_hsa041400.46469888
88DNA replication_Homo sapiens_hsa030300.44414239
89Ribosome_Homo sapiens_hsa030100.44364937
90Arginine and proline metabolism_Homo sapiens_hsa003300.43922499
91cAMP signaling pathway_Homo sapiens_hsa040240.41442067
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.41058497
93Alzheimers disease_Homo sapiens_hsa050100.39919430
94Melanogenesis_Homo sapiens_hsa049160.39116665
95Fructose and mannose metabolism_Homo sapiens_hsa000510.37913449
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37096166
97Cocaine addiction_Homo sapiens_hsa050300.37086580
98Tyrosine metabolism_Homo sapiens_hsa003500.33313368
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32624821
100Collecting duct acid secretion_Homo sapiens_hsa049660.31762301

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