SERBP1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.29157055
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.42205034
3cytidine deamination (GO:0009972)5.98725398
4cytidine metabolic process (GO:0046087)5.98725398
5cytidine catabolic process (GO:0006216)5.98725398
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.06411026
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.92098257
8negative regulation by host of viral transcription (GO:0043922)4.77764546
9positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.39262189
10rRNA catabolic process (GO:0016075)4.31326500
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02751184
12ncRNA catabolic process (GO:0034661)4.01794390
137-methylguanosine mRNA capping (GO:0006370)3.86085439
14apoptotic DNA fragmentation (GO:0006309)3.82904412
15pseudouridine synthesis (GO:0001522)3.82488889
16proteasome assembly (GO:0043248)3.81302795
17microtubule depolymerization (GO:0007019)3.81128643
18L-fucose metabolic process (GO:0042354)3.75672069
19L-fucose catabolic process (GO:0042355)3.75672069
20fucose catabolic process (GO:0019317)3.75672069
217-methylguanosine RNA capping (GO:0009452)3.75437226
22RNA capping (GO:0036260)3.75437226
23DNA damage response, detection of DNA damage (GO:0042769)3.70545363
24sulfate transport (GO:0008272)3.62175179
25positive regulation of muscle cell apoptotic process (GO:0010661)3.56705696
26cytokinetic process (GO:0032506)3.51075742
27replication fork processing (GO:0031297)3.50872230
28mitotic metaphase plate congression (GO:0007080)3.47009630
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42841169
30organelle disassembly (GO:1903008)3.41804969
31transcription elongation from RNA polymerase I promoter (GO:0006362)3.34779160
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.33349728
33chaperone-mediated protein transport (GO:0072321)3.31805427
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.31264507
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29040121
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27034500
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26094383
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.26094383
39NADH dehydrogenase complex assembly (GO:0010257)3.26094383
40response to xenobiotic stimulus (GO:0009410)3.23481412
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23209541
42ribonucleoprotein complex disassembly (GO:0032988)3.22977190
43termination of RNA polymerase III transcription (GO:0006386)3.20761410
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.20761410
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16884957
46ATP synthesis coupled proton transport (GO:0015986)3.16884957
47protein complex biogenesis (GO:0070271)3.15203471
48spliceosomal snRNP assembly (GO:0000387)3.06718285
49formation of translation preinitiation complex (GO:0001731)3.05855764
50CENP-A containing nucleosome assembly (GO:0034080)3.04050390
51regulation of acyl-CoA biosynthetic process (GO:0050812)2.99110336
52centriole replication (GO:0007099)2.98987818
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98334140
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.98214393
55DNA ligation (GO:0006266)2.97803946
56chromatin remodeling at centromere (GO:0031055)2.96435316
57IMP biosynthetic process (GO:0006188)2.96041513
58mitochondrial respiratory chain complex assembly (GO:0033108)2.89827970
59G-protein coupled receptor internalization (GO:0002031)2.88093265
60termination of RNA polymerase I transcription (GO:0006363)2.87674361
61maturation of SSU-rRNA (GO:0030490)2.87014750
62DNA replication checkpoint (GO:0000076)2.86233666
63histone mRNA metabolic process (GO:0008334)2.84738802
64protein localization to kinetochore (GO:0034501)2.84446087
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82181522
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.82181522
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82181522
68transcription from RNA polymerase I promoter (GO:0006360)2.81853379
69respiratory chain complex IV assembly (GO:0008535)2.78859386
70modulation by host of symbiont transcription (GO:0052472)2.77982884
71modulation by host of viral transcription (GO:0043921)2.77982884
72rRNA metabolic process (GO:0016072)2.76591362
73cellular ketone body metabolic process (GO:0046950)2.75620119
74purine nucleobase biosynthetic process (GO:0009113)2.75614718
75ribosomal small subunit assembly (GO:0000028)2.75256809
76histone exchange (GO:0043486)2.74283914
77DNA excision (GO:0044349)2.73749418
78nucleotide-excision repair, DNA damage removal (GO:0000718)2.73749418
79IMP metabolic process (GO:0046040)2.73566416
80positive regulation of DNA-templated transcription, elongation (GO:0032786)2.73464769
81rRNA processing (GO:0006364)2.73430882
82behavioral response to nicotine (GO:0035095)2.71816747
83modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.71142786
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70004154
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69492421
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69195941
87nucleobase biosynthetic process (GO:0046112)2.68524962
88electron transport chain (GO:0022900)2.68371933
89cytochrome complex assembly (GO:0017004)2.66831944
90respiratory electron transport chain (GO:0022904)2.66500105
91regulation of cofactor metabolic process (GO:0051193)2.66070820
92regulation of coenzyme metabolic process (GO:0051196)2.66070820
93regulation of sulfur metabolic process (GO:0042762)2.64813300
94ribosome assembly (GO:0042255)2.63523202
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63242783
96platelet dense granule organization (GO:0060155)2.63200130
97N-terminal protein amino acid acetylation (GO:0006474)2.63143473
98positive regulation of defense response to virus by host (GO:0002230)2.61945818
99regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.60561213
100attachment of spindle microtubules to kinetochore (GO:0008608)2.59568770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68630885
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98828670
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.69372680
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.45113565
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32131794
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.17155193
7VDR_22108803_ChIP-Seq_LS180_Human3.04253886
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99243301
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98874453
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.77586623
11VDR_23849224_ChIP-Seq_CD4+_Human2.66812857
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65766471
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54465657
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46445468
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.45581231
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.37472052
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35084838
18ELK1_19687146_ChIP-ChIP_HELA_Human2.34264209
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31483310
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28151349
21FOXP3_21729870_ChIP-Seq_TREG_Human2.20774392
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.06755589
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06420049
24EWS_26573619_Chip-Seq_HEK293_Human1.96758316
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95942163
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.94175964
27ZNF274_21170338_ChIP-Seq_K562_Hela1.91384667
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89513089
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85869009
30E2F7_22180533_ChIP-Seq_HELA_Human1.85305564
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77869428
32TTF2_22483619_ChIP-Seq_HELA_Human1.74795919
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69341931
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67622861
35MYC_18940864_ChIP-ChIP_HL60_Human1.67139214
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.63857639
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62869471
38TAF15_26573619_Chip-Seq_HEK293_Human1.62503531
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60372019
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60032251
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.57412306
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53926634
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50411809
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50062464
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46305515
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42028326
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37208172
48FUS_26573619_Chip-Seq_HEK293_Human1.36163182
49GABP_19822575_ChIP-Seq_HepG2_Human1.35761650
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34230993
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32364627
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29969622
53CBP_20019798_ChIP-Seq_JUKART_Human1.29969622
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26228081
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.25286110
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24215849
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22167404
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22161972
59DCP1A_22483619_ChIP-Seq_HELA_Human1.21792817
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21445333
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21323175
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19772184
63XRN2_22483619_ChIP-Seq_HELA_Human1.18856462
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17548644
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14875463
66P300_19829295_ChIP-Seq_ESCs_Human1.14581757
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14348324
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09907037
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09487051
70NANOG_19829295_ChIP-Seq_ESCs_Human1.08459404
71SOX2_19829295_ChIP-Seq_ESCs_Human1.08459404
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08079811
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.08079811
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06037926
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05986646
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03575927
77TP53_22573176_ChIP-Seq_HFKS_Human1.02959787
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02486251
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02286341
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00203655
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98209200
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97603559
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97195965
84HOXB7_26014856_ChIP-Seq_BT474_Human0.97117713
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97069069
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97069069
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95988129
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95225769
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94385161
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93695924
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.92616377
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92208545
93CIITA_25753668_ChIP-Seq_RAJI_Human0.91030731
94ER_23166858_ChIP-Seq_MCF-7_Human0.89975623
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.89356598
96TCF4_22108803_ChIP-Seq_LS180_Human0.88926643
97HTT_18923047_ChIP-ChIP_STHdh_Human0.87624534
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87362625
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86446970
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85315427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.02071695
2MP0006292_abnormal_olfactory_placode3.32736188
3MP0009379_abnormal_foot_pigmentation3.32327286
4MP0009697_abnormal_copulation3.22831042
5MP0002163_abnormal_gland_morphology2.96410952
6MP0005174_abnormal_tail_pigmentation2.44585625
7MP0006072_abnormal_retinal_apoptosis2.32941474
8MP0004957_abnormal_blastocyst_morpholog2.30032776
9MP0008058_abnormal_DNA_repair2.29568008
10MP0008877_abnormal_DNA_methylation2.25534219
11MP0003136_yellow_coat_color2.20595768
12MP0001293_anophthalmia2.14584303
13MP0000569_abnormal_digit_pigmentation2.13133820
14MP0005377_hearing/vestibular/ear_phenot2.08717649
15MP0003878_abnormal_ear_physiology2.08717649
16MP0006035_abnormal_mitochondrial_morpho2.00289102
17MP0002736_abnormal_nociception_after1.96639409
18MP0010094_abnormal_chromosome_stability1.96085983
19MP0003646_muscle_fatigue1.94774488
20MP0005084_abnormal_gallbladder_morpholo1.90027830
21MP0003786_premature_aging1.83758248
22MP0005379_endocrine/exocrine_gland_phen1.83387473
23MP0003183_abnormal_peptide_metabolism1.82720056
24MP0001968_abnormal_touch/_nociception1.81265301
25MP0002837_dystrophic_cardiac_calcinosis1.80918598
26MP0003252_abnormal_bile_duct1.77810903
27MP0002102_abnormal_ear_morphology1.75099048
28MP0005671_abnormal_response_to1.73742013
29MP0003718_maternal_effect1.70943052
30MP0000372_irregular_coat_pigmentation1.59014365
31MP0003567_abnormal_fetal_cardiomyocyte1.57008101
32MP0004145_abnormal_muscle_electrophysio1.55244544
33MP0003806_abnormal_nucleotide_metabolis1.54531615
34MP0005645_abnormal_hypothalamus_physiol1.46225734
35MP0008875_abnormal_xenobiotic_pharmacok1.44702715
36MP0002938_white_spotting1.44330013
37MP0003111_abnormal_nucleus_morphology1.43211902
38MP0003890_abnormal_embryonic-extraembry1.38747938
39MP0004142_abnormal_muscle_tone1.38076275
40MP0003119_abnormal_digestive_system1.37155609
41MP0008872_abnormal_physiological_respon1.36264891
42MP0001529_abnormal_vocalization1.30843237
43MP0002254_reproductive_system_inflammat1.30767062
44MP0001835_abnormal_antigen_presentation1.30599065
45MP0003195_calcinosis1.29820672
46MP0002095_abnormal_skin_pigmentation1.24435928
47MP0005253_abnormal_eye_physiology1.20545567
48MP0008932_abnormal_embryonic_tissue1.19667298
49MP0004133_heterotaxia1.19044064
50MP0003787_abnormal_imprinting1.18799092
51MP0002277_abnormal_respiratory_mucosa1.16943278
52MP0002138_abnormal_hepatobiliary_system1.14944960
53MP0001919_abnormal_reproductive_system1.13829334
54MP0000015_abnormal_ear_pigmentation1.12751430
55MP0002006_tumorigenesis1.09949303
56MP0000631_abnormal_neuroendocrine_gland1.06111543
57MP0005551_abnormal_eye_electrophysiolog1.05960632
58MP0003693_abnormal_embryo_hatching1.04641898
59MP0000537_abnormal_urethra_morphology1.04077524
60MP0003077_abnormal_cell_cycle1.03745093
61MP0005187_abnormal_penis_morphology1.01447364
62MP0008961_abnormal_basal_metabolism0.97225591
63MP0005410_abnormal_fertilization0.96713046
64MP0003221_abnormal_cardiomyocyte_apopto0.95545395
65MP0006036_abnormal_mitochondrial_physio0.95400985
66MP0005075_abnormal_melanosome_morpholog0.93458340
67MP0001485_abnormal_pinna_reflex0.93002513
68MP0003763_abnormal_thymus_physiology0.91707714
69MP0002166_altered_tumor_susceptibility0.91165485
70MP0005389_reproductive_system_phenotype0.90087659
71MP0004215_abnormal_myocardial_fiber0.89487078
72MP0001730_embryonic_growth_arrest0.89267772
73MP0001764_abnormal_homeostasis0.86214057
74MP0002396_abnormal_hematopoietic_system0.85963555
75MP0004147_increased_porphyrin_level0.85942682
76MP0001697_abnormal_embryo_size0.84754125
77MP0002090_abnormal_vision0.83129780
78MP0002160_abnormal_reproductive_system0.81844081
79MP0003315_abnormal_perineum_morphology0.81000537
80MP0006054_spinal_hemorrhage0.80372338
81MP0000647_abnormal_sebaceous_gland0.79643648
82MP0000613_abnormal_salivary_gland0.75213248
83MP0008995_early_reproductive_senescence0.74857095
84MP0000358_abnormal_cell_content/0.74336684
85MP0004885_abnormal_endolymph0.74154173
86MP0002210_abnormal_sex_determination0.73451710
87MP0001879_abnormal_lymphatic_vessel0.73131943
88MP0005646_abnormal_pituitary_gland0.72869291
89MP0003186_abnormal_redox_activity0.71804493
90MP0005636_abnormal_mineral_homeostasis0.71189699
91MP0006276_abnormal_autonomic_nervous0.70740553
92MP0003937_abnormal_limbs/digits/tail_de0.67856093
93MP0000703_abnormal_thymus_morphology0.66880600
94MP0004084_abnormal_cardiac_muscle0.66245637
95MP0001145_abnormal_male_reproductive0.64974130
96MP0001286_abnormal_eye_development0.64704964
97MP0004742_abnormal_vestibular_system0.64600113
98MP0000313_abnormal_cell_death0.64425463
99MP0002009_preneoplasia0.63875145
100MP0004924_abnormal_behavior0.63395295

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)3.82018884
2Progressive inability to walk (HP:0002505)3.49815481
3Acute necrotizing encephalopathy (HP:0006965)3.42592849
4Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.23728429
5Abnormality of DNA repair (HP:0003254)3.23434591
6Abnormality of alanine metabolism (HP:0010916)3.14667052
7Hyperalaninemia (HP:0003348)3.14667052
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14667052
9Mitochondrial inheritance (HP:0001427)3.09960373
10Inability to walk (HP:0002540)3.07547598
11Increased CSF lactate (HP:0002490)3.03221301
12Sensory axonal neuropathy (HP:0003390)3.01252762
13Methylmalonic aciduria (HP:0012120)3.00938188
14Increased serum pyruvate (HP:0003542)2.97890783
15Confusion (HP:0001289)2.92058420
16Abnormality of the labia minora (HP:0012880)2.89221093
17Methylmalonic acidemia (HP:0002912)2.83371433
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80844695
19Abnormal mitochondria in muscle tissue (HP:0008316)2.78976122
20Acute encephalopathy (HP:0006846)2.72863926
21Progressive macrocephaly (HP:0004481)2.71618273
22Increased hepatocellular lipid droplets (HP:0006565)2.71524570
23Abnormal number of erythroid precursors (HP:0012131)2.67162766
24Clumsiness (HP:0002312)2.64773416
25Severe combined immunodeficiency (HP:0004430)2.61666702
26Metaphyseal dysplasia (HP:0100255)2.59060778
27Increased serum lactate (HP:0002151)2.57277901
28IgG deficiency (HP:0004315)2.54980582
29Amyotrophic lateral sclerosis (HP:0007354)2.52733985
30Hyperglycinemia (HP:0002154)2.49734347
31Prominent metopic ridge (HP:0005487)2.45023576
32Congenital stationary night blindness (HP:0007642)2.42558292
33Abnormality of cells of the erythroid lineage (HP:0012130)2.41303924
34Birth length less than 3rd percentile (HP:0003561)2.40750561
35Combined immunodeficiency (HP:0005387)2.34521470
36Colon cancer (HP:0003003)2.33908997
37Hepatocellular necrosis (HP:0001404)2.32807979
38Lipid accumulation in hepatocytes (HP:0006561)2.32471672
39Diastasis recti (HP:0001540)2.31017990
40Abnormality of glycolysis (HP:0004366)2.30035768
41Cerebral edema (HP:0002181)2.28682637
42Entropion (HP:0000621)2.26644160
43Elevated erythrocyte sedimentation rate (HP:0003565)2.21826784
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.21556671
45Premature ovarian failure (HP:0008209)2.17406310
46Abnormality of serum amino acid levels (HP:0003112)2.17271126
47Progressive muscle weakness (HP:0003323)2.16909581
48Lactic acidosis (HP:0003128)2.14842226
49Lower limb hyperreflexia (HP:0002395)2.13574642
50Cleft eyelid (HP:0000625)2.12384607
51Abnormality of midbrain morphology (HP:0002418)2.10081222
52Molar tooth sign on MRI (HP:0002419)2.10081222
53Ragged-red muscle fibers (HP:0003200)2.09404174
54Hypoplasia of the uterus (HP:0000013)2.08683922
55Poikiloderma (HP:0001029)2.06791384
56Thyroiditis (HP:0100646)2.06234050
57Progressive external ophthalmoplegia (HP:0000590)2.05864364
58Abnormality of the metopic suture (HP:0005556)2.04361848
59Stenosis of the external auditory canal (HP:0000402)2.03851940
60Pendular nystagmus (HP:0012043)2.03540366
61Hepatic necrosis (HP:0002605)2.00438844
62Abnormality of magnesium homeostasis (HP:0004921)1.99867563
63Posterior subcapsular cataract (HP:0007787)1.99047565
64Lethargy (HP:0001254)1.98243561
65Optic disc pallor (HP:0000543)1.94912267
66Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93674796
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93674796
68Pancytopenia (HP:0001876)1.93369356
69Hypoproteinemia (HP:0003075)1.92212833
70Neonatal respiratory distress (HP:0002643)1.91204340
71Aplasia/hypoplasia of the uterus (HP:0008684)1.91202730
72Patellar aplasia (HP:0006443)1.90932742
73Anomalous pulmonary venous return (HP:0010772)1.85738705
74Absent thumb (HP:0009777)1.84943750
75Brittle hair (HP:0002299)1.83621313
76Type II lissencephaly (HP:0007260)1.81654979
77Rib fusion (HP:0000902)1.81207143
78Cerebral hypomyelination (HP:0006808)1.80998788
79Hyperglycinuria (HP:0003108)1.79069726
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.77784865
81Cutaneous melanoma (HP:0012056)1.76820300
82Aplasia/Hypoplasia of the patella (HP:0006498)1.75024893
83Abnormality of T cells (HP:0002843)1.74805343
84Chromsome breakage (HP:0040012)1.72249453
85True hermaphroditism (HP:0010459)1.71304906
86Hypomagnesemia (HP:0002917)1.71141585
87Abnormal rod and cone electroretinograms (HP:0008323)1.70002564
88Ketoacidosis (HP:0001993)1.69889521
89Macrocytic anemia (HP:0001972)1.69447236
90T lymphocytopenia (HP:0005403)1.69148071
91Long clavicles (HP:0000890)1.68684107
92Mesangial abnormality (HP:0001966)1.67092632
93Hypoalbuminemia (HP:0003073)1.66238382
94Abnormal albumin level (HP:0012116)1.66238382
95Chronic diarrhea (HP:0002028)1.65022183
96Homocystinuria (HP:0002156)1.64451823
97Abnormality of homocysteine metabolism (HP:0010919)1.64451823
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63718154
99Hypoplasia of the thymus (HP:0000778)1.63495269
100Leukodystrophy (HP:0002415)1.62875724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.77152297
2DYRK34.33455536
3ZAK3.62671690
4STK163.46400261
5TXK2.83574950
6VRK22.48994164
7WNK42.41106292
8NUAK12.41066469
9VRK12.09371392
10NEK12.08988218
11TNIK2.07804720
12CDC71.91047369
13MAP4K21.85640703
14PLK31.68435147
15BUB11.62034706
16KDR1.61672095
17ADRBK21.54690361
18TLK11.54315573
19NLK1.52109637
20TSSK61.49758207
21OXSR11.49653544
22MAPKAPK31.44748135
23TAF11.43767511
24TTK1.26409275
25PNCK1.24353427
26WEE11.19997421
27STK391.18053385
28PLK11.17148923
29WNK31.11451561
30RPS6KA41.09328538
31ALK1.05837429
32DYRK21.03610152
33SRPK11.02771789
34PDK20.99630667
35GRK10.93416747
36CLK10.93280575
37PLK40.91940157
38MKNK20.90897216
39AKT20.90397186
40AKT30.89661866
41TAOK30.88522315
42ATR0.85946254
43PASK0.84431189
44CCNB10.83209185
45RPS6KB20.80242996
46CDK190.79066713
47BRSK20.78484446
48STK100.78015899
49AURKB0.76999585
50EIF2AK30.76995378
51MAP3K30.76018889
52RPS6KA50.75445307
53CHEK10.75079529
54PINK10.73906714
55TRIM280.69614296
56MAPK130.69111331
57MKNK10.68072195
58PRKCQ0.65423052
59STK38L0.65174664
60BMPR20.61410413
61ITK0.61241884
62INSRR0.59954925
63EEF2K0.59664714
64FRK0.59556559
65AURKA0.53574545
66ABL20.51288049
67PBK0.50733660
68MUSK0.50156075
69BCKDK0.49620292
70PRKCI0.47125677
71IKBKB0.44720788
72OBSCN0.43710650
73CSNK2A10.42495563
74ATM0.42136758
75MAP4K10.41522797
76MAPK140.41419187
77CHEK20.39611551
78CSNK2A20.38763695
79PRKCE0.37891901
80MAPKAPK50.35756931
81TIE10.34913070
82PLK20.34755222
83IRAK10.32857977
84MAP3K80.32487546
85PAK10.30410069
86SGK20.30100474
87CSF1R0.29807865
88HIPK20.29382389
89NEK20.29340456
90CSNK1A10.28693403
91TRPM70.28419009
92CDK10.28341165
93CSNK1E0.28321365
94MAP2K20.27695916
95CDK20.26033275
96WNK10.25563837
97LIMK10.25474861
98MAP3K140.25349106
99SGK4940.24282652
100SGK2230.24282652

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33389387
2Proteasome_Homo sapiens_hsa030503.27764455
3Oxidative phosphorylation_Homo sapiens_hsa001902.77363277
4Basal transcription factors_Homo sapiens_hsa030222.77151555
5RNA polymerase_Homo sapiens_hsa030202.70649687
6Antigen processing and presentation_Homo sapiens_hsa046122.58594170
7Parkinsons disease_Homo sapiens_hsa050122.50503377
8One carbon pool by folate_Homo sapiens_hsa006702.45276768
9Protein export_Homo sapiens_hsa030602.31893767
10Ribosome_Homo sapiens_hsa030102.17267716
11RNA degradation_Homo sapiens_hsa030182.13622063
12Homologous recombination_Homo sapiens_hsa034402.12101155
13Nucleotide excision repair_Homo sapiens_hsa034201.94556686
14RNA transport_Homo sapiens_hsa030131.91400967
15Huntingtons disease_Homo sapiens_hsa050161.89547020
16DNA replication_Homo sapiens_hsa030301.89338079
17Asthma_Homo sapiens_hsa053101.85238454
18Non-homologous end-joining_Homo sapiens_hsa034501.82212447
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80126187
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.79894869
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79791589
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74516366
23Primary immunodeficiency_Homo sapiens_hsa053401.73462154
24Spliceosome_Homo sapiens_hsa030401.69532367
25Propanoate metabolism_Homo sapiens_hsa006401.62419945
26Graft-versus-host disease_Homo sapiens_hsa053321.60277145
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58800946
28Autoimmune thyroid disease_Homo sapiens_hsa053201.57512225
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52962347
30Allograft rejection_Homo sapiens_hsa053301.44764082
31Alzheimers disease_Homo sapiens_hsa050101.44004503
32Phototransduction_Homo sapiens_hsa047441.42645399
33Linoleic acid metabolism_Homo sapiens_hsa005911.38158071
34Mismatch repair_Homo sapiens_hsa034301.35205411
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.34635832
36Pyrimidine metabolism_Homo sapiens_hsa002401.31897483
37Systemic lupus erythematosus_Homo sapiens_hsa053221.28889190
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28432520
39Type I diabetes mellitus_Homo sapiens_hsa049401.26982365
40Olfactory transduction_Homo sapiens_hsa047401.26427083
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24234753
42Purine metabolism_Homo sapiens_hsa002301.19106663
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19061212
44Cardiac muscle contraction_Homo sapiens_hsa042601.17290814
45Regulation of autophagy_Homo sapiens_hsa041401.15593321
46Pyruvate metabolism_Homo sapiens_hsa006201.12425659
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06711075
48Butanoate metabolism_Homo sapiens_hsa006501.04744578
49Base excision repair_Homo sapiens_hsa034100.97447245
50Fanconi anemia pathway_Homo sapiens_hsa034600.96391290
51beta-Alanine metabolism_Homo sapiens_hsa004100.93589730
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92836132
53Glutathione metabolism_Homo sapiens_hsa004800.92709187
54Viral myocarditis_Homo sapiens_hsa054160.88682648
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.84873748
56Ether lipid metabolism_Homo sapiens_hsa005650.83493274
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83331135
58Selenocompound metabolism_Homo sapiens_hsa004500.83087717
59Nitrogen metabolism_Homo sapiens_hsa009100.81125545
60Rheumatoid arthritis_Homo sapiens_hsa053230.75413615
61Vitamin digestion and absorption_Homo sapiens_hsa049770.75105853
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71637819
63mRNA surveillance pathway_Homo sapiens_hsa030150.69664863
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67135154
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66746406
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63962755
67Fat digestion and absorption_Homo sapiens_hsa049750.63887842
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.62666355
69Epstein-Barr virus infection_Homo sapiens_hsa051690.61385089
70p53 signaling pathway_Homo sapiens_hsa041150.59467163
71Cell cycle_Homo sapiens_hsa041100.57191821
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56558633
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55900434
74Sulfur metabolism_Homo sapiens_hsa009200.53542973
75Metabolic pathways_Homo sapiens_hsa011000.50687362
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48888807
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48036122
78Alcoholism_Homo sapiens_hsa050340.45378646
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44595192
80Tight junction_Homo sapiens_hsa045300.42165741
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41049757
82Collecting duct acid secretion_Homo sapiens_hsa049660.40307587
83Arginine and proline metabolism_Homo sapiens_hsa003300.39046728
84Herpes simplex infection_Homo sapiens_hsa051680.38951868
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38843410
86Peroxisome_Homo sapiens_hsa041460.34145858
87Hematopoietic cell lineage_Homo sapiens_hsa046400.33921806
88Morphine addiction_Homo sapiens_hsa050320.31256815
89Tryptophan metabolism_Homo sapiens_hsa003800.29425122
90Serotonergic synapse_Homo sapiens_hsa047260.27172972
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27122033
92Arachidonic acid metabolism_Homo sapiens_hsa005900.26403979
93Glycerolipid metabolism_Homo sapiens_hsa005610.22475207
94Caffeine metabolism_Homo sapiens_hsa002320.21624220
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18011895
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.12616712
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10816724
98Wnt signaling pathway_Homo sapiens_hsa043100.10222299
99Nicotine addiction_Homo sapiens_hsa050330.09992195
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09146981

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