SEPT7P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)4.79818303
2protein polyglutamylation (GO:0018095)4.78312386
3cellular ketone body metabolic process (GO:0046950)4.57787766
4cornea development in camera-type eye (GO:0061303)4.49975534
5behavioral response to nicotine (GO:0035095)4.48596422
6regulation of cilium movement (GO:0003352)4.15069086
7DNA deamination (GO:0045006)4.11211628
8ketone body metabolic process (GO:1902224)4.02710237
9positive regulation of cell fate commitment (GO:0010455)3.73336416
10somite development (GO:0061053)3.71497913
11epithelial cilium movement (GO:0003351)3.58265036
12piRNA metabolic process (GO:0034587)3.44590902
13sperm motility (GO:0030317)3.43108656
14ATP synthesis coupled proton transport (GO:0015986)3.32192339
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32192339
16axoneme assembly (GO:0035082)3.29846517
17regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.28232218
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.27534455
19cilium morphogenesis (GO:0060271)3.25010992
20protein complex biogenesis (GO:0070271)3.24535181
21histone H2A acetylation (GO:0043968)3.22995677
22nonmotile primary cilium assembly (GO:0035058)3.18981132
23regulation of development, heterochronic (GO:0040034)3.18276750
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15262308
25regulation of timing of cell differentiation (GO:0048505)3.12436010
26mannosylation (GO:0097502)3.09761988
27response to pheromone (GO:0019236)3.08984879
28estrogen biosynthetic process (GO:0006703)3.07775582
29DNA double-strand break processing (GO:0000729)3.05151567
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04148883
31regulation of microtubule-based movement (GO:0060632)3.01847814
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01435913
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.01435913
34NADH dehydrogenase complex assembly (GO:0010257)3.01435913
35axonemal dynein complex assembly (GO:0070286)3.01410900
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00689407
37water-soluble vitamin biosynthetic process (GO:0042364)2.99495394
38L-methionine salvage (GO:0071267)2.97361466
39L-methionine biosynthetic process (GO:0071265)2.97361466
40amino acid salvage (GO:0043102)2.97361466
41positive regulation of defense response to virus by host (GO:0002230)2.96980002
42acrosome reaction (GO:0007340)2.96075065
43regulation of glucokinase activity (GO:0033131)2.95810664
44regulation of hexokinase activity (GO:1903299)2.95810664
45inositol phosphate catabolic process (GO:0071545)2.93419596
46RNA destabilization (GO:0050779)2.91279297
47cilium movement (GO:0003341)2.89306703
48signal peptide processing (GO:0006465)2.87790058
49intraciliary transport (GO:0042073)2.87461240
50phosphatidylethanolamine metabolic process (GO:0046337)2.86430548
51male meiosis (GO:0007140)2.85241852
52tryptophan catabolic process (GO:0006569)2.84762556
53indole-containing compound catabolic process (GO:0042436)2.84762556
54indolalkylamine catabolic process (GO:0046218)2.84762556
55multicellular organism reproduction (GO:0032504)2.84179373
56mitochondrial respiratory chain complex assembly (GO:0033108)2.83218047
57spermatid development (GO:0007286)2.82645791
58phosphatidylethanolamine biosynthetic process (GO:0006646)2.80108740
59regulation of feeding behavior (GO:0060259)2.78088177
60adenosine metabolic process (GO:0046085)2.76995423
61regulation of activation of Janus kinase activity (GO:0010533)2.76817555
62negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75806180
63preassembly of GPI anchor in ER membrane (GO:0016254)2.75398223
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74785497
65negative regulation of membrane potential (GO:0045837)2.71257168
66purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.70547043
67glycerophospholipid catabolic process (GO:0046475)2.70295310
68proteasome assembly (GO:0043248)2.69188178
69protein localization to cilium (GO:0061512)2.69138147
70fucose catabolic process (GO:0019317)2.67073503
71L-fucose metabolic process (GO:0042354)2.67073503
72L-fucose catabolic process (GO:0042355)2.67073503
73GPI anchor metabolic process (GO:0006505)2.66773956
74negative regulation of mast cell activation (GO:0033004)2.65728314
75ADP metabolic process (GO:0046031)2.65074740
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63565371
77cilium organization (GO:0044782)2.61784050
78phosphorylated carbohydrate dephosphorylation (GO:0046838)2.61312266
79inositol phosphate dephosphorylation (GO:0046855)2.61312266
80resolution of meiotic recombination intermediates (GO:0000712)2.61190357
81indolalkylamine metabolic process (GO:0006586)2.60698740
82establishment of protein localization to Golgi (GO:0072600)2.59641924
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59389062
84pituitary gland development (GO:0021983)2.59267394
85photoreceptor cell development (GO:0042461)2.58725110
86cilium assembly (GO:0042384)2.57289984
87sulfation (GO:0051923)2.57191156
88cytidine deamination (GO:0009972)2.57038102
89cytidine metabolic process (GO:0046087)2.57038102
90cytidine catabolic process (GO:0006216)2.57038102
91DNA methylation involved in gamete generation (GO:0043046)2.55727177
92gamma-aminobutyric acid transport (GO:0015812)2.55067918
93spermatid nucleus differentiation (GO:0007289)2.54925536
94magnesium ion transport (GO:0015693)2.54641971
95molting cycle (GO:0042303)2.52076145
96hair cycle (GO:0042633)2.52076145
97protein targeting to Golgi (GO:0000042)2.51087305
98platelet dense granule organization (GO:0060155)2.50927944
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50193091
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50193091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.49723204
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04273177
3VDR_22108803_ChIP-Seq_LS180_Human2.70243387
4IGF1R_20145208_ChIP-Seq_DFB_Human2.56544341
5GBX2_23144817_ChIP-Seq_PC3_Human2.53098569
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40190625
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.39036278
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37209255
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34535556
10FUS_26573619_Chip-Seq_HEK293_Human2.32401250
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32348108
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24108420
13TAF15_26573619_Chip-Seq_HEK293_Human2.18012067
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14176283
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.07462575
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99079577
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97874033
18P300_19829295_ChIP-Seq_ESCs_Human1.95763217
19ER_23166858_ChIP-Seq_MCF-7_Human1.93677719
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.92968051
21EWS_26573619_Chip-Seq_HEK293_Human1.86125277
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83544503
23CBP_20019798_ChIP-Seq_JUKART_Human1.83544503
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73975809
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72819208
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72666096
27TP53_22573176_ChIP-Seq_HFKS_Human1.61005632
28GATA1_22025678_ChIP-Seq_K562_Human1.60112111
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59782151
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59156021
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58426714
32VDR_23849224_ChIP-Seq_CD4+_Human1.57900833
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56750499
34NANOG_19829295_ChIP-Seq_ESCs_Human1.51997505
35SOX2_19829295_ChIP-Seq_ESCs_Human1.51997505
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50569163
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50149105
38ELK1_19687146_ChIP-ChIP_HELA_Human1.49435920
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49183203
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47044949
41MYC_18940864_ChIP-ChIP_HL60_Human1.45982628
42AR_25329375_ChIP-Seq_VCAP_Human1.45407014
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.45330885
44SMAD4_21799915_ChIP-Seq_A2780_Human1.40023472
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.37696945
46STAT3_23295773_ChIP-Seq_U87_Human1.35680885
47BCAT_22108803_ChIP-Seq_LS180_Human1.33596542
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31025343
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.31025343
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30485160
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29982744
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29661706
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29373963
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29271455
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.26611705
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26346340
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.24256556
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23638798
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22998978
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.22632588
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22096606
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20369440
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.19471664
64RNF2_27304074_Chip-Seq_NSC_Mouse1.18921231
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.18552710
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.18465050
67NCOR_22424771_ChIP-Seq_293T_Human1.17514477
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.17387659
69RUNX2_22187159_ChIP-Seq_PCA_Human1.16739772
70TCF4_22108803_ChIP-Seq_LS180_Human1.16669412
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15341365
72IRF1_19129219_ChIP-ChIP_H3396_Human1.15136225
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14887179
74MYC_19829295_ChIP-Seq_ESCs_Human1.14222405
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13465868
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13438028
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13361103
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13256348
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13050436
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.12388446
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12094344
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11146539
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.11078249
84HOXB7_26014856_ChIP-Seq_BT474_Human1.10617136
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.09999716
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09963791
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05240723
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.04392663
89REST_21632747_ChIP-Seq_MESCs_Mouse1.02390486
90AR_20517297_ChIP-Seq_VCAP_Human1.02140286
91FOXH1_21741376_ChIP-Seq_EPCs_Human1.02093452
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02017890
93TCF4_23295773_ChIP-Seq_U87_Human1.01197066
94GATA3_26560356_Chip-Seq_TH2_Human1.00911003
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00885739
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99129728
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.98446666
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98256058
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98256058
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98139004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.57364342
2MP0006072_abnormal_retinal_apoptosis3.04526741
3MP0008877_abnormal_DNA_methylation2.99922752
4MP0006292_abnormal_olfactory_placode2.94884922
5MP0005084_abnormal_gallbladder_morpholo2.51174125
6MP0002638_abnormal_pupillary_reflex2.40975309
7MP0005410_abnormal_fertilization2.39182371
8MP0008789_abnormal_olfactory_epithelium2.27189561
9MP0001984_abnormal_olfaction2.26906979
10MP0000372_irregular_coat_pigmentation2.20056392
11MP0002938_white_spotting2.10156959
12MP0001968_abnormal_touch/_nociception2.09413106
13MP0003787_abnormal_imprinting2.08961326
14MP0001529_abnormal_vocalization2.04213220
15MP0005645_abnormal_hypothalamus_physiol1.98604225
16MP0005253_abnormal_eye_physiology1.98336615
17MP0004147_increased_porphyrin_level1.97937112
18MP0005551_abnormal_eye_electrophysiolog1.96256156
19MP0002138_abnormal_hepatobiliary_system1.90079316
20MP0003880_abnormal_central_pattern1.88632496
21MP0002837_dystrophic_cardiac_calcinosis1.83158869
22MP0002102_abnormal_ear_morphology1.79480474
23MP0002736_abnormal_nociception_after1.75424661
24MP0005499_abnormal_olfactory_system1.74630132
25MP0005394_taste/olfaction_phenotype1.74630132
26MP0009745_abnormal_behavioral_response1.69336621
27MP0009046_muscle_twitch1.68903868
28MP0004142_abnormal_muscle_tone1.67067084
29MP0005646_abnormal_pituitary_gland1.65121323
30MP0002876_abnormal_thyroid_physiology1.64594433
31MP0003011_delayed_dark_adaptation1.45920102
32MP0006276_abnormal_autonomic_nervous1.44796623
33MP0002272_abnormal_nervous_system1.44546138
34MP0002822_catalepsy1.43892472
35MP0001986_abnormal_taste_sensitivity1.43661172
36MP0002653_abnormal_ependyma_morphology1.43107889
37MP0001764_abnormal_homeostasis1.42637290
38MP0003698_abnormal_male_reproductive1.38420281
39MP0002735_abnormal_chemical_nociception1.37452609
40MP0010386_abnormal_urinary_bladder1.33532695
41MP0000631_abnormal_neuroendocrine_gland1.31102026
42MP0004885_abnormal_endolymph1.30796665
43MP0001929_abnormal_gametogenesis1.29980425
44MP0003283_abnormal_digestive_organ1.28488694
45MP0001486_abnormal_startle_reflex1.28356908
46MP0008875_abnormal_xenobiotic_pharmacok1.25862617
47MP0008995_early_reproductive_senescence1.25259502
48MP0008872_abnormal_physiological_respon1.23578855
49MP0004133_heterotaxia1.21068534
50MP0003806_abnormal_nucleotide_metabolis1.20125418
51MP0001970_abnormal_pain_threshold1.18737599
52MP0002160_abnormal_reproductive_system1.14875614
53MP0005075_abnormal_melanosome_morpholog1.14332204
54MP0002064_seizures1.14314632
55MP0001944_abnormal_pancreas_morphology1.10706977
56MP0002572_abnormal_emotion/affect_behav1.10592893
57MP0001440_abnormal_grooming_behavior1.09746350
58MP0000427_abnormal_hair_cycle1.07361578
59MP0002733_abnormal_thermal_nociception1.06603272
60MP0001501_abnormal_sleep_pattern1.05826341
61MP0002557_abnormal_social/conspecific_i1.04195841
62MP0005367_renal/urinary_system_phenotyp1.03241871
63MP0000516_abnormal_urinary_system1.03241871
64MP0005389_reproductive_system_phenotype1.01186929
65MP0003252_abnormal_bile_duct1.00438255
66MP0002928_abnormal_bile_duct1.00158709
67MP0002693_abnormal_pancreas_physiology0.99139987
68MP0001919_abnormal_reproductive_system0.97546316
69MP0003635_abnormal_synaptic_transmissio0.95910145
70MP0000613_abnormal_salivary_gland0.93238298
71MP0001485_abnormal_pinna_reflex0.91772583
72MP0005332_abnormal_amino_acid0.91451665
73MP0002067_abnormal_sensory_capabilities0.90067014
74MP0008058_abnormal_DNA_repair0.88709947
75MP0001905_abnormal_dopamine_level0.87227665
76MP0001765_abnormal_ion_homeostasis0.84295250
77MP0009697_abnormal_copulation0.83454519
78MP0002282_abnormal_trachea_morphology0.82578151
79MP0002751_abnormal_autonomic_nervous0.82254082
80MP0005085_abnormal_gallbladder_physiolo0.82167931
81MP0001502_abnormal_circadian_rhythm0.81876094
82MP0003718_maternal_effect0.81245887
83MP0000653_abnormal_sex_gland0.81117231
84MP0000013_abnormal_adipose_tissue0.80467039
85MP0002063_abnormal_learning/memory/cond0.79447525
86MP0005636_abnormal_mineral_homeostasis0.79311703
87MP0005379_endocrine/exocrine_gland_phen0.78742354
88MP0001188_hyperpigmentation0.78347130
89MP0001963_abnormal_hearing_physiology0.78121303
90MP0002734_abnormal_mechanical_nocicepti0.78062831
91MP0005195_abnormal_posterior_eye0.77960206
92MP0002210_abnormal_sex_determination0.77160971
93MP0001145_abnormal_male_reproductive0.77133926
94MP0005448_abnormal_energy_balance0.76557664
95MP0010329_abnormal_lipoprotein_level0.74460853
96MP0005386_behavior/neurological_phenoty0.74388537
97MP0004924_abnormal_behavior0.74388537
98MP0003646_muscle_fatigue0.73675439
99MP0005365_abnormal_bile_salt0.72927177
100MP0000026_abnormal_inner_ear0.72832047

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.79252388
2True hermaphroditism (HP:0010459)3.51638578
3Pancreatic fibrosis (HP:0100732)3.39028048
4Hypothermia (HP:0002045)3.36474520
53-Methylglutaconic aciduria (HP:0003535)3.32149763
6Abnormality of midbrain morphology (HP:0002418)3.30661757
7Molar tooth sign on MRI (HP:0002419)3.30661757
8Nephronophthisis (HP:0000090)3.29981289
9Methylmalonic acidemia (HP:0002912)3.18505663
10Medial flaring of the eyebrow (HP:0010747)3.13137169
11Hypoplasia of the fovea (HP:0007750)3.06737754
12Aplasia/Hypoplasia of the fovea (HP:0008060)3.06737754
13Absent/shortened dynein arms (HP:0200106)2.94998897
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.94998897
15Congenital stationary night blindness (HP:0007642)2.94231956
16Abnormality of the renal cortex (HP:0011035)2.87925398
17Acute necrotizing encephalopathy (HP:0006965)2.83320792
18Generalized aminoaciduria (HP:0002909)2.74373151
19Renal cortical cysts (HP:0000803)2.73722142
20Mitochondrial inheritance (HP:0001427)2.73242387
21Hepatic necrosis (HP:0002605)2.72267291
22Gait imbalance (HP:0002141)2.71227603
23Progressive macrocephaly (HP:0004481)2.70237241
24Methylmalonic aciduria (HP:0012120)2.67327513
25Hepatocellular necrosis (HP:0001404)2.64302772
26Abnormality of the renal medulla (HP:0100957)2.63241188
27Ketoacidosis (HP:0001993)2.62191728
28Abnormality of the fovea (HP:0000493)2.61975570
29Abnormal mitochondria in muscle tissue (HP:0008316)2.59574947
30Abolished electroretinogram (ERG) (HP:0000550)2.58307794
31Abnormal respiratory epithelium morphology (HP:0012253)2.56657389
32Abnormal respiratory motile cilium morphology (HP:0005938)2.56657389
33Congenital primary aphakia (HP:0007707)2.55953869
34Pendular nystagmus (HP:0012043)2.47553168
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45709284
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45709284
37Attenuation of retinal blood vessels (HP:0007843)2.41299983
38Abnormality of vitamin B metabolism (HP:0004340)2.40870578
39Chronic hepatic failure (HP:0100626)2.40109401
40Ketosis (HP:0001946)2.37551139
41Abnormal ciliary motility (HP:0012262)2.37184114
42Optic nerve hypoplasia (HP:0000609)2.36816389
43Increased CSF lactate (HP:0002490)2.29613782
44Male pseudohermaphroditism (HP:0000037)2.23558258
45Acute encephalopathy (HP:0006846)2.23491940
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19949558
47Abnormal rod and cone electroretinograms (HP:0008323)2.19048939
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.15882342
49Abnormality of the pancreatic islet cells (HP:0006476)2.13907138
50Abnormality of endocrine pancreas physiology (HP:0012093)2.13907138
51Hyperventilation (HP:0002883)2.13904196
52Abnormal respiratory motile cilium physiology (HP:0012261)2.13362244
53Type II lissencephaly (HP:0007260)2.09441195
54Thyroiditis (HP:0100646)2.09395971
55Cerebral edema (HP:0002181)2.05517814
56Nephrogenic diabetes insipidus (HP:0009806)2.05423464
57Hypoglycemic coma (HP:0001325)2.04271089
58Optic disc pallor (HP:0000543)2.03698128
59Sclerocornea (HP:0000647)2.01701034
60Pancreatic islet-cell hyperplasia (HP:0004510)2.01644554
61Aplasia/hypoplasia of the uterus (HP:0008684)1.99764232
62Polydipsia (HP:0001959)1.99132842
63Abnormal drinking behavior (HP:0030082)1.99132842
64Cystic liver disease (HP:0006706)1.97357604
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.97116865
66Rhinitis (HP:0012384)1.95625113
67Abnormality of urine glucose concentration (HP:0011016)1.93163253
68Glycosuria (HP:0003076)1.93163253
69Genital tract atresia (HP:0001827)1.92984741
70Furrowed tongue (HP:0000221)1.92883954
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91716774
72Intestinal atresia (HP:0011100)1.91045669
73Hemiparesis (HP:0001269)1.90587323
74Vaginal atresia (HP:0000148)1.90058226
75Polyphagia (HP:0002591)1.89383897
76Hypoplasia of the uterus (HP:0000013)1.88256532
77Decreased central vision (HP:0007663)1.87244919
78Anencephaly (HP:0002323)1.87158591
79Hyperinsulinemic hypoglycemia (HP:0000825)1.86602221
80Broad-based gait (HP:0002136)1.86262847
81Abnormality of macular pigmentation (HP:0008002)1.86142990
82Thyroid-stimulating hormone excess (HP:0002925)1.84567021
83Dicarboxylic aciduria (HP:0003215)1.84416251
84Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84416251
85Congenital hepatic fibrosis (HP:0002612)1.81579320
86Keratoconus (HP:0000563)1.80991320
87Increased corneal curvature (HP:0100692)1.80991320
88Optic neuritis (HP:0100653)1.78072983
89Retrobulbar optic neuritis (HP:0100654)1.78072983
90Large for gestational age (HP:0001520)1.77799588
91Keratitis (HP:0000491)1.77155050
92Type I transferrin isoform profile (HP:0003642)1.74916170
93Postaxial hand polydactyly (HP:0001162)1.74888438
94Median cleft lip (HP:0000161)1.69853491
95Inability to walk (HP:0002540)1.68066156
96Increased serum lactate (HP:0002151)1.67523751
97Poor head control (HP:0002421)1.66525316
98Abnormality of DNA repair (HP:0003254)1.65673846
99Hypomagnesemia (HP:0002917)1.64365304
100Optic nerve coloboma (HP:0000588)1.64055962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.93062860
2MAP4K24.10588795
3INSRR3.04530071
4ADRBK22.88757811
5ZAK2.42731369
6BCKDK2.37456808
7PINK12.30489057
8MAPK132.15628164
9TLK12.11125501
10FGFR22.08342982
11NUAK12.02441077
12TAOK31.96142457
13EIF2AK31.94905207
14CASK1.92858433
15WNK31.89323858
16GRK11.88183896
17MAP3K41.72484122
18TXK1.70475394
19EPHA31.61570119
20STK38L1.58744365
21TRIM281.55666176
22DYRK21.39607490
23VRK11.37431854
24MAP2K71.29939800
25STK161.28335173
26PHKG11.25477239
27PHKG21.25477239
28RPS6KA51.22627433
29PTK2B1.20737306
30PAK31.19119935
31PLK21.14311623
32WNK41.13268251
33MAPK151.07510045
34IKBKB0.97592689
35VRK20.96537247
36PRKCE0.96507864
37NTRK30.96008873
38BMPR1B0.93790901
39TNIK0.92807461
40MARK10.92456465
41CSNK1G30.92398944
42CSNK1G20.92208314
43TSSK60.91333084
44MUSK0.90120762
45EPHA40.89856701
46RPS6KA40.88953684
47PLK30.88493998
48CSNK1G10.88437813
49CDK190.87713640
50NLK0.87473232
51BCR0.87182414
52ERBB30.83987944
53IRAK10.81022860
54BRSK20.80199395
55PRKCG0.78197773
56CSNK1A1L0.76617027
57TIE10.75910912
58PLK40.72521915
59HIPK20.71590431
60OXSR10.70414277
61PKN10.69344569
62PASK0.62101204
63DAPK20.61600914
64MARK30.60179975
65KDR0.60095700
66MAPKAPK50.59628125
67PNCK0.58278594
68CDK30.55304075
69BRD40.53532310
70PRKCQ0.51266127
71STK390.51085056
72MAP3K90.47948895
73PRKCI0.47247919
74NTRK20.46763918
75MST40.46717991
76OBSCN0.46703690
77CSNK1A10.45726891
78CHUK0.43684470
79PIM20.43491276
80FER0.42657418
81PIK3CG0.42463290
82ADRBK10.42126712
83KIT0.39263123
84DYRK30.38390366
85GRK70.37774251
86PRKACA0.37420622
87SGK2230.35509295
88SGK4940.35509295
89TEC0.35360359
90IKBKE0.33428612
91MAP3K120.32129797
92ACVR1B0.32013892
93RAF10.31149588
94MYLK0.30127056
95CAMKK20.29098223
96GRK50.26547688
97STK30.26279349
98CDK80.24932584
99SGK20.24322567
100ITK0.23893278

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.43828659
2Protein export_Homo sapiens_hsa030603.30884854
3Oxidative phosphorylation_Homo sapiens_hsa001903.08345028
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07852192
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69728048
6Butanoate metabolism_Homo sapiens_hsa006502.52132911
7Parkinsons disease_Homo sapiens_hsa050122.27927422
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24813098
9Phototransduction_Homo sapiens_hsa047442.19278276
10Nicotine addiction_Homo sapiens_hsa050332.08242322
11Propanoate metabolism_Homo sapiens_hsa006402.08111998
12Sulfur metabolism_Homo sapiens_hsa009201.85002821
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79013026
14Proteasome_Homo sapiens_hsa030501.57560018
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56555935
16Alzheimers disease_Homo sapiens_hsa050101.53621617
17Fanconi anemia pathway_Homo sapiens_hsa034601.53369725
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52378250
19Regulation of autophagy_Homo sapiens_hsa041401.50431309
20RNA polymerase_Homo sapiens_hsa030201.50041780
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48670079
22Huntingtons disease_Homo sapiens_hsa050161.45127723
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43722072
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.40313684
25RNA degradation_Homo sapiens_hsa030181.38659609
26Type I diabetes mellitus_Homo sapiens_hsa049401.33448884
27Chemical carcinogenesis_Homo sapiens_hsa052041.29362650
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25908917
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25318601
30Selenocompound metabolism_Homo sapiens_hsa004501.24017175
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23674172
32Nitrogen metabolism_Homo sapiens_hsa009101.22453536
33Taste transduction_Homo sapiens_hsa047421.21081114
34Linoleic acid metabolism_Homo sapiens_hsa005911.19788194
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19399653
36Collecting duct acid secretion_Homo sapiens_hsa049661.17535276
37Peroxisome_Homo sapiens_hsa041461.16338537
38Steroid biosynthesis_Homo sapiens_hsa001001.15465708
39Retinol metabolism_Homo sapiens_hsa008301.14989861
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.13664733
41Caffeine metabolism_Homo sapiens_hsa002321.10419432
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10385185
43Tryptophan metabolism_Homo sapiens_hsa003801.09775134
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09453063
45Basal transcription factors_Homo sapiens_hsa030221.07615788
46Asthma_Homo sapiens_hsa053101.01816636
47Cardiac muscle contraction_Homo sapiens_hsa042601.01810685
48GABAergic synapse_Homo sapiens_hsa047271.00751413
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98158699
50Olfactory transduction_Homo sapiens_hsa047400.97192327
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95626524
52Insulin secretion_Homo sapiens_hsa049110.94122505
53Graft-versus-host disease_Homo sapiens_hsa053320.89856179
54Homologous recombination_Homo sapiens_hsa034400.89370030
55Circadian rhythm_Homo sapiens_hsa047100.88730588
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87626022
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.87332596
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86232791
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82392271
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75808532
61Autoimmune thyroid disease_Homo sapiens_hsa053200.74942695
62Circadian entrainment_Homo sapiens_hsa047130.74022052
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71681830
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71428108
65Metabolic pathways_Homo sapiens_hsa011000.71343563
66Purine metabolism_Homo sapiens_hsa002300.67293280
67Fatty acid elongation_Homo sapiens_hsa000620.67093238
68Ether lipid metabolism_Homo sapiens_hsa005650.67034732
69Allograft rejection_Homo sapiens_hsa053300.66941883
70Systemic lupus erythematosus_Homo sapiens_hsa053220.65647249
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65131932
72Morphine addiction_Homo sapiens_hsa050320.64656165
73Serotonergic synapse_Homo sapiens_hsa047260.63949613
74Folate biosynthesis_Homo sapiens_hsa007900.62780749
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61648547
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61020994
77Cocaine addiction_Homo sapiens_hsa050300.60958475
78One carbon pool by folate_Homo sapiens_hsa006700.59806668
79Glutamatergic synapse_Homo sapiens_hsa047240.58836917
80Synaptic vesicle cycle_Homo sapiens_hsa047210.57811467
81Alcoholism_Homo sapiens_hsa050340.56543599
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56215408
83Amphetamine addiction_Homo sapiens_hsa050310.55436200
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54931040
85Hedgehog signaling pathway_Homo sapiens_hsa043400.52729524
86Antigen processing and presentation_Homo sapiens_hsa046120.49862589
87Fatty acid metabolism_Homo sapiens_hsa012120.48400147
88Vitamin digestion and absorption_Homo sapiens_hsa049770.46879054
89Arachidonic acid metabolism_Homo sapiens_hsa005900.46853731
90Rheumatoid arthritis_Homo sapiens_hsa053230.45185213
91beta-Alanine metabolism_Homo sapiens_hsa004100.44701878
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.44560049
93Fat digestion and absorption_Homo sapiens_hsa049750.42311903
94ABC transporters_Homo sapiens_hsa020100.39077423
95Nucleotide excision repair_Homo sapiens_hsa034200.37989244
96Fatty acid degradation_Homo sapiens_hsa000710.36387759
97Dopaminergic synapse_Homo sapiens_hsa047280.35931947
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35926955
99Pyrimidine metabolism_Homo sapiens_hsa002400.35420805
100Sulfur relay system_Homo sapiens_hsa041220.33793160

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