SEPT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.85737248
2central nervous system myelination (GO:0022010)9.85737248
3fatty acid elongation (GO:0030497)6.18660937
4myelination (GO:0042552)5.72513338
5axon ensheathment (GO:0008366)5.69948386
6ensheathment of neurons (GO:0007272)5.69948386
7long-chain fatty acid biosynthetic process (GO:0042759)5.64088347
8presynaptic membrane organization (GO:0097090)5.12372017
9presynaptic membrane assembly (GO:0097105)5.03351880
10negative regulation of neurotransmitter transport (GO:0051589)5.00819012
11negative regulation of neurotransmitter secretion (GO:0046929)4.83778939
12neuron cell-cell adhesion (GO:0007158)4.46641821
13negative regulation of protein localization to cell surface (GO:2000009)4.28200280
14L-amino acid import (GO:0043092)4.03539911
15myelin maintenance (GO:0043217)3.96555978
16regulation of collateral sprouting (GO:0048670)3.89886562
17DNA double-strand break processing (GO:0000729)3.86023367
18C4-dicarboxylate transport (GO:0015740)3.79948677
19pyrimidine nucleobase catabolic process (GO:0006208)3.79591782
20oligodendrocyte differentiation (GO:0048709)3.77221356
21cholesterol biosynthetic process (GO:0006695)3.75537757
22establishment of mitochondrion localization (GO:0051654)3.72681809
23auditory behavior (GO:0031223)3.72541712
24substantia nigra development (GO:0021762)3.69029678
25neuronal action potential propagation (GO:0019227)3.67158168
26synaptic vesicle maturation (GO:0016188)3.64849350
27gamma-aminobutyric acid transport (GO:0015812)3.62193339
28apical protein localization (GO:0045176)3.56041753
29negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.55067155
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54067806
31response to redox state (GO:0051775)3.47273048
32glycerophospholipid catabolic process (GO:0046475)3.45579519
33astrocyte development (GO:0014002)3.45067053
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43643084
35positive regulation of oligodendrocyte differentiation (GO:0048714)3.42726226
36neurotransmitter uptake (GO:0001504)3.40517632
37protein neddylation (GO:0045116)3.40488229
38cerebral cortex radially oriented cell migration (GO:0021799)3.39164431
39asymmetric protein localization (GO:0008105)3.38971802
40photoreceptor cell differentiation (GO:0046530)3.35270520
41eye photoreceptor cell differentiation (GO:0001754)3.35270520
42transmission of nerve impulse (GO:0019226)3.34086038
43neurotransmitter-gated ion channel clustering (GO:0072578)3.32476260
44sterol biosynthetic process (GO:0016126)3.30715714
45vocalization behavior (GO:0071625)3.26144026
46response to methylmercury (GO:0051597)3.23642764
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.21939324
48amino acid import (GO:0043090)3.20750906
49adult walking behavior (GO:0007628)3.18741296
50neuron remodeling (GO:0016322)3.15396409
51neuron recognition (GO:0008038)3.14184499
52cerebellar granule cell differentiation (GO:0021707)3.10443299
53isoprenoid biosynthetic process (GO:0008299)3.09473198
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08871629
55membrane assembly (GO:0071709)3.08836351
56limb bud formation (GO:0060174)3.07788933
57negative regulation of axonogenesis (GO:0050771)3.05118336
58regulation of synapse structural plasticity (GO:0051823)2.99072576
59nucleobase catabolic process (GO:0046113)2.97320491
60glycosphingolipid biosynthetic process (GO:0006688)2.97062579
61synaptic vesicle exocytosis (GO:0016079)2.95602610
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94188928
63regulation of synaptic vesicle transport (GO:1902803)2.93483033
64creatine metabolic process (GO:0006600)2.90017860
65myelination in peripheral nervous system (GO:0022011)2.88319743
66peripheral nervous system axon ensheathment (GO:0032292)2.88319743
67regulation of cell communication by electrical coupling (GO:0010649)2.88123773
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84640364
69protein palmitoylation (GO:0018345)2.84036905
70platelet dense granule organization (GO:0060155)2.83598568
71regulation of voltage-gated calcium channel activity (GO:1901385)2.80871032
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80263312
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.79895599
74negative regulation of axon extension (GO:0030517)2.78850636
75import into cell (GO:0098657)2.78212480
76nonmotile primary cilium assembly (GO:0035058)2.77954096
77response to auditory stimulus (GO:0010996)2.77492869
78regulation of synaptic vesicle exocytosis (GO:2000300)2.76798897
79cellular potassium ion homeostasis (GO:0030007)2.75744207
80mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.75610443
81protein localization to cilium (GO:0061512)2.75497797
82vascular smooth muscle contraction (GO:0014829)2.75418017
83cellular response to epinephrine stimulus (GO:0071872)2.75377612
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75372841
85potassium ion import (GO:0010107)2.74737110
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.74727793
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.74005354
88axonal fasciculation (GO:0007413)2.71416229
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.71151481
90magnesium ion transport (GO:0015693)2.69176130
91ionotropic glutamate receptor signaling pathway (GO:0035235)2.69076527
92negative regulation of synaptic transmission (GO:0050805)2.68748987
93positive regulation of action potential (GO:0045760)2.68341663
94acidic amino acid transport (GO:0015800)2.68204472
95cullin deneddylation (GO:0010388)2.67080851
96nerve growth factor signaling pathway (GO:0038180)2.66721106
97mechanosensory behavior (GO:0007638)2.65912517
98neuron-neuron synaptic transmission (GO:0007270)2.63551902
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63135157
100glutamate receptor signaling pathway (GO:0007215)2.61548374
101protein localization to synapse (GO:0035418)2.61439381
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59886561
103peripheral nervous system development (GO:0007422)2.59689396
104regulation of dendritic spine development (GO:0060998)2.59462708
105neurotransmitter secretion (GO:0007269)2.59343562
106regulation of dendritic spine morphogenesis (GO:0061001)2.58964940
107response to epinephrine (GO:0071871)2.58158340
108glutamate secretion (GO:0014047)2.57891640
109neural nucleus development (GO:0048857)2.57499063
110startle response (GO:0001964)2.56599969
111positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.56393598
112negative regulation of heart rate (GO:0010459)2.55837943
113positive regulation of synapse assembly (GO:0051965)2.55704250
114membrane tubulation (GO:0097320)2.55597880
115retinal cone cell development (GO:0046549)2.55183922
116regulation of synaptic transmission, GABAergic (GO:0032228)2.54900712
117axon development (GO:0061564)2.54577578
118GPI anchor biosynthetic process (GO:0006506)2.54068078
119microtubule polymerization or depolymerization (GO:0031109)2.54028579
120amyloid precursor protein metabolic process (GO:0042982)2.53076740
121regulation of cardiac muscle cell contraction (GO:0086004)2.51967982
122cyclic nucleotide catabolic process (GO:0009214)2.51038102
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.50281145
124protein polyglutamylation (GO:0018095)2.49603190
125postsynaptic membrane organization (GO:0001941)2.48781254
126long-term synaptic potentiation (GO:0060291)2.47942762
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47909391
128negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.47779740
129intraciliary transport (GO:0042073)2.47394367
130synapse assembly (GO:0007416)2.46773369
131positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46572473
132microtubule depolymerization (GO:0007019)2.46489588
133GPI anchor metabolic process (GO:0006505)2.45786817
134neuronal ion channel clustering (GO:0045161)2.45776323
135adhesion of symbiont to host cell (GO:0044650)2.45281555
136virion attachment to host cell (GO:0019062)2.45281555
137regulation of dopamine metabolic process (GO:0042053)2.45238174
138regulation of catecholamine metabolic process (GO:0042069)2.45238174
139detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44613004
140detection of temperature stimulus involved in sensory perception (GO:0050961)2.44613004
141dendrite development (GO:0016358)2.43601206
142response to lipoprotein particle (GO:0055094)2.43381440
143synaptic transmission, glutamatergic (GO:0035249)2.43105530
144exploration behavior (GO:0035640)2.42950788
145regulation of synapse assembly (GO:0051963)2.42857273
146negative regulation of JUN kinase activity (GO:0043508)2.41571898
147regulation of neurotransmitter uptake (GO:0051580)2.40919354
148peptidyl-cysteine modification (GO:0018198)2.40621687
149regulation of neurotransmitter transport (GO:0051588)2.40503669
150central nervous system projection neuron axonogenesis (GO:0021952)2.38574691
151L-glutamate transport (GO:0015813)2.37155907
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.37152550
153regulation of neurotransmitter secretion (GO:0046928)2.37068483
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34802985
155negative regulation of DNA recombination (GO:0045910)2.34719276
156protein deneddylation (GO:0000338)2.34453782
157detection of calcium ion (GO:0005513)2.33870224
158regulation of excitatory postsynaptic membrane potential (GO:0060079)2.33748704
159locomotory exploration behavior (GO:0035641)2.33136776
160cell morphogenesis involved in neuron differentiation (GO:0048667)2.32763393
161resolution of meiotic recombination intermediates (GO:0000712)2.32247129
162regulation of cilium movement (GO:0003352)2.32054169
163dendrite morphogenesis (GO:0048813)2.31551914
164regulation of respiratory system process (GO:0044065)2.31204604
165neural tube formation (GO:0001841)2.29202033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.10960913
2EZH2_22144423_ChIP-Seq_EOC_Human3.24440775
3TAF15_26573619_Chip-Seq_HEK293_Human2.90775704
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70051516
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65249276
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.60197950
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51680385
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42050321
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.37056134
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26241063
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.24557467
12OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24309767
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23243644
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.20311033
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16945453
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16299310
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16299310
18ZNF274_21170338_ChIP-Seq_K562_Hela2.16158055
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15749956
20AR_21572438_ChIP-Seq_LNCaP_Human2.09686115
21VDR_22108803_ChIP-Seq_LS180_Human2.08616953
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02297554
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99147238
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94413599
25FUS_26573619_Chip-Seq_HEK293_Human1.93167054
26ER_23166858_ChIP-Seq_MCF-7_Human1.89654002
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89074358
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88755494
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87423749
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85522382
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85223364
32P300_19829295_ChIP-Seq_ESCs_Human1.80684269
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.76321540
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.73061111
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72694386
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.70834761
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.69627371
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.68150946
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65378587
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63158644
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60985733
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60887814
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57528239
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54795655
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54560449
46ELK1_19687146_ChIP-ChIP_HELA_Human1.53407813
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52633415
48SMAD4_21799915_ChIP-Seq_A2780_Human1.52147828
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49770780
50BCAT_22108803_ChIP-Seq_LS180_Human1.48241505
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.47899180
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47161881
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44620656
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43606224
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43006026
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42284445
57REST_21632747_ChIP-Seq_MESCs_Mouse1.38793411
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35501117
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34698503
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34372391
61DROSHA_22980978_ChIP-Seq_HELA_Human1.34066392
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33305732
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.32935152
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32860426
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32860426
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32268143
67CBP_20019798_ChIP-Seq_JUKART_Human1.32268143
68RNF2_27304074_Chip-Seq_NSC_Mouse1.31690711
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31103688
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29668033
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.28064781
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27244987
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26532809
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25512337
75STAT3_23295773_ChIP-Seq_U87_Human1.25333460
76EWS_26573619_Chip-Seq_HEK293_Human1.24777077
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.24658759
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.24384646
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24234374
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.23856849
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22227610
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21688119
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.21277772
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21153279
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21120936
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18426895
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17702070
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17656318
89TCF4_22108803_ChIP-Seq_LS180_Human1.17057845
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16801787
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.16352561
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16123406
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15769990
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15761108
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.15697129
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15372343
97TCF4_23295773_ChIP-Seq_U87_Human1.15141583
98IGF1R_20145208_ChIP-Seq_DFB_Human1.14476694
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14107582
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14107582
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13258832
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12646533
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12131380
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.11786362
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.11651776
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.11531256
107TP53_18474530_ChIP-ChIP_U2OS_Human1.10477494
108P300_18555785_Chip-Seq_ESCs_Mouse1.10351216
109P53_22387025_ChIP-Seq_ESCs_Mouse1.09896063
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09721110
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09216275
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.08693643
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.08507675
114SOX2_19829295_ChIP-Seq_ESCs_Human1.08230094
115NANOG_19829295_ChIP-Seq_ESCs_Human1.08230094
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.07219358
117JUN_21703547_ChIP-Seq_K562_Human1.06809386
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06323269
119TP53_16413492_ChIP-PET_HCT116_Human1.06156877
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06113660
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05924371
122RUNX2_22187159_ChIP-Seq_PCA_Human1.05215975
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.04145542
124AR_25329375_ChIP-Seq_VCAP_Human1.03844747
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03052046
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02728664
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02590813
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01957680
129SOX9_26525672_Chip-Seq_HEART_Mouse1.01726523
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00011541
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.99288118
132KDM2B_26808549_Chip-Seq_REH_Human0.99108563
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.98582969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.12578851
2MP0000920_abnormal_myelination4.28290278
3MP0004270_analgesia3.29255927
4MP0004859_abnormal_synaptic_plasticity3.05828936
5MP0005171_absent_coat_pigmentation2.84613016
6MP0003950_abnormal_plasma_membrane2.77825119
7MP0002272_abnormal_nervous_system2.74306801
8MP0001529_abnormal_vocalization2.73812797
9MP0002064_seizures2.72883008
10MP0000569_abnormal_digit_pigmentation2.59890032
11MP0001486_abnormal_startle_reflex2.55992341
12MP0003635_abnormal_synaptic_transmissio2.54990592
13MP0001905_abnormal_dopamine_level2.49829786
14MP0009745_abnormal_behavioral_response2.48084201
15MP0008877_abnormal_DNA_methylation2.40345813
16MP0009046_muscle_twitch2.39825681
17MP0004742_abnormal_vestibular_system2.38608529
18MP0003690_abnormal_glial_cell2.31986706
19MP0000778_abnormal_nervous_system2.25946002
20MP0003136_yellow_coat_color2.19581130
21MP0003329_amyloid_beta_deposits2.16535946
22MP0002734_abnormal_mechanical_nocicepti2.16380057
23MP0004142_abnormal_muscle_tone2.04988501
24MP0005423_abnormal_somatic_nervous2.04195958
25MP0002063_abnormal_learning/memory/cond2.01038470
26MP0002572_abnormal_emotion/affect_behav2.00398424
27MP0002102_abnormal_ear_morphology1.97333953
28MP0001968_abnormal_touch/_nociception1.95298441
29MP0003634_abnormal_glial_cell1.93874896
30MP0004885_abnormal_endolymph1.93776817
31MP0005409_darkened_coat_color1.86481889
32MP0001440_abnormal_grooming_behavior1.82576198
33MP0001485_abnormal_pinna_reflex1.82174060
34MP0002638_abnormal_pupillary_reflex1.77629616
35MP0002736_abnormal_nociception_after1.75954220
36MP0002067_abnormal_sensory_capabilities1.64783405
37MP0001970_abnormal_pain_threshold1.58081323
38MP0008569_lethality_at_weaning1.51256004
39MP0003632_abnormal_nervous_system1.50291250
40MP0002735_abnormal_chemical_nociception1.49083005
41MP0002229_neurodegeneration1.47867982
42MP0004134_abnormal_chest_morphology1.47711886
43MP0005623_abnormal_meninges_morphology1.47597543
44MP0004215_abnormal_myocardial_fiber1.44319100
45MP0003121_genomic_imprinting1.41723533
46MP0000955_abnormal_spinal_cord1.41681637
47MP0005386_behavior/neurological_phenoty1.41469414
48MP0004924_abnormal_behavior1.41469414
49MP0003631_nervous_system_phenotype1.39047050
50MP0002882_abnormal_neuron_morphology1.38521725
51MP0002733_abnormal_thermal_nociception1.34518747
52MP0005551_abnormal_eye_electrophysiolog1.31486314
53MP0002066_abnormal_motor_capabilities/c1.31210431
54MP0003633_abnormal_nervous_system1.31077244
55MP0005410_abnormal_fertilization1.29981754
56MP0008058_abnormal_DNA_repair1.28803755
57MP0001963_abnormal_hearing_physiology1.28096102
58MP0005187_abnormal_penis_morphology1.23371437
59MP0001501_abnormal_sleep_pattern1.20316918
60MP0006054_spinal_hemorrhage1.19135118
61MP0005394_taste/olfaction_phenotype1.17677642
62MP0005499_abnormal_olfactory_system1.17677642
63MP0004043_abnormal_pH_regulation1.15728250
64MP0008260_abnormal_autophagy1.14622186
65MP0004145_abnormal_muscle_electrophysio1.13269407
66MP0002751_abnormal_autonomic_nervous1.12261805
67MP0001299_abnormal_eye_distance/1.11436318
68MP0001188_hyperpigmentation1.10844235
69MP0002184_abnormal_innervation1.08869077
70MP0008789_abnormal_olfactory_epithelium1.06629081
71MP0009780_abnormal_chondrocyte_physiolo1.06560413
72MP0002752_abnormal_somatic_nervous1.05545373
73MP0005646_abnormal_pituitary_gland1.04405630
74MP0002233_abnormal_nose_morphology1.03353208
75MP0001177_atelectasis1.03307499
76MP0010678_abnormal_skin_adnexa1.01893996
77MP0006276_abnormal_autonomic_nervous1.01306184
78MP0000516_abnormal_urinary_system0.99512475
79MP0005367_renal/urinary_system_phenotyp0.99512475
80MP0004147_increased_porphyrin_level0.99112191
81MP0002557_abnormal_social/conspecific_i0.98975458
82MP0005248_abnormal_Harderian_gland0.98396498
83MP0000462_abnormal_digestive_system0.97685526
84MP0001986_abnormal_taste_sensitivity0.96710537
85MP0002095_abnormal_skin_pigmentation0.96217263
86MP0000647_abnormal_sebaceous_gland0.96064273
87MP0000604_amyloidosis0.95369701
88MP0008438_abnormal_cutaneous_collagen0.92650681
89MP0000427_abnormal_hair_cycle0.92425996
90MP0002152_abnormal_brain_morphology0.89339850
91MP0005174_abnormal_tail_pigmentation0.86471605
92MP0000383_abnormal_hair_follicle0.85555788
93MP0003938_abnormal_ear_development0.85482114
94MP0004811_abnormal_neuron_physiology0.85033670
95MP0003122_maternal_imprinting0.83483763
96MP0000026_abnormal_inner_ear0.83221719
97MP0003137_abnormal_impulse_conducting0.82095939
98MP0002822_catalepsy0.81876820
99MP0005084_abnormal_gallbladder_morpholo0.81698980
100MP0003890_abnormal_embryonic-extraembry0.81684219
101MP0001502_abnormal_circadian_rhythm0.81292909
102MP0003119_abnormal_digestive_system0.80461909
103MP0002938_white_spotting0.80382221
104MP0005645_abnormal_hypothalamus_physiol0.78371011
105MP0005195_abnormal_posterior_eye0.78335792
106MP0000566_synostosis0.78202735
107MP0004381_abnormal_hair_follicle0.77718932
108MP0002234_abnormal_pharynx_morphology0.77052518
109MP0000631_abnormal_neuroendocrine_gland0.77023549
110MP0010094_abnormal_chromosome_stability0.76791380
111MP0003385_abnormal_body_wall0.76105263
112MP0008872_abnormal_physiological_respon0.74708606
113MP0001661_extended_life_span0.74646629
114MP0003861_abnormal_nervous_system0.73670497
115MP0000639_abnormal_adrenal_gland0.72779963
116MP0000747_muscle_weakness0.72237411
117MP0009250_abnormal_appendicular_skeleto0.71317666
118MP0005253_abnormal_eye_physiology0.70749939
119MP0001293_anophthalmia0.70581925
120MP0001984_abnormal_olfaction0.70139215
121MP0004036_abnormal_muscle_relaxation0.69662671
122MP0001346_abnormal_lacrimal_gland0.69248716
123MP0000013_abnormal_adipose_tissue0.68448813
124MP0002295_abnormal_pulmonary_circulatio0.68415670
125MP0001943_abnormal_respiration0.66557339
126MP0000762_abnormal_tongue_morphology0.65702430
127MP0003787_abnormal_imprinting0.64211530
128MP0002090_abnormal_vision0.63506200
129MP0006072_abnormal_retinal_apoptosis0.63331357
130MP0000372_irregular_coat_pigmentation0.61724064
131MP0002133_abnormal_respiratory_system0.61559966
132MP0005388_respiratory_system_phenotype0.61559966
133MP0003937_abnormal_limbs/digits/tail_de0.59528688
134MP0004085_abnormal_heartbeat0.58406123

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.18059947
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.18059947
3Neurofibrillary tangles (HP:0002185)5.24472319
4Abnormality of the corticospinal tract (HP:0002492)4.57604144
5Sensory axonal neuropathy (HP:0003390)4.23888503
6Parakeratosis (HP:0001036)4.04352058
7Focal motor seizures (HP:0011153)3.98037850
8Cerebral inclusion bodies (HP:0100314)3.94807791
9Peripheral hypomyelination (HP:0007182)3.93405536
10Hemiparesis (HP:0001269)3.85977210
11Termporal pattern (HP:0011008)3.56241943
12Insidious onset (HP:0003587)3.56241943
13Myokymia (HP:0002411)3.43190130
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37864323
15Abnormality of glycolysis (HP:0004366)3.32624999
16Increased serum pyruvate (HP:0003542)3.32624999
17Cerebral hypomyelination (HP:0006808)3.22170150
18Febrile seizures (HP:0002373)3.21842603
19Spastic gait (HP:0002064)3.20383553
20Supranuclear gaze palsy (HP:0000605)3.17337431
21Atonic seizures (HP:0010819)3.07937908
22Dysmetria (HP:0001310)3.02317142
23Volvulus (HP:0002580)3.02045867
24Scanning speech (HP:0002168)2.99576318
25Epileptic encephalopathy (HP:0200134)2.99004334
26Onion bulb formation (HP:0003383)2.98569634
27Abnormal auditory evoked potentials (HP:0006958)2.92933326
28Leukodystrophy (HP:0002415)2.91704919
29Pheochromocytoma (HP:0002666)2.87203665
30Retinal dysplasia (HP:0007973)2.84134712
31Alacrima (HP:0000522)2.82092024
32Hemiplegia (HP:0002301)2.78446157
33Hyperventilation (HP:0002883)2.78435718
34Thickened helices (HP:0000391)2.69334401
35Neuroendocrine neoplasm (HP:0100634)2.68616053
36Ankle clonus (HP:0011448)2.67320344
37Intention tremor (HP:0002080)2.63273290
38True hermaphroditism (HP:0010459)2.60478059
39Abnormality of the labia minora (HP:0012880)2.60118658
40Autoamputation (HP:0001218)2.59849938
41Amyotrophic lateral sclerosis (HP:0007354)2.59653592
42Nephrogenic diabetes insipidus (HP:0009806)2.59461172
43Drooling (HP:0002307)2.59396370
44Generalized tonic-clonic seizures (HP:0002069)2.58181752
45Focal seizures (HP:0007359)2.52812610
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.51829279
47Akinesia (HP:0002304)2.48617050
48Acute necrotizing encephalopathy (HP:0006965)2.47648874
49Short tibia (HP:0005736)2.44395327
50Broad-based gait (HP:0002136)2.42058864
51Cerebral hemorrhage (HP:0001342)2.39791054
52Clumsiness (HP:0002312)2.34094537
53Polyphagia (HP:0002591)2.33728143
54Hypoplastic pelvis (HP:0008839)2.33056861
55Excessive salivation (HP:0003781)2.32265570
56Intestinal atresia (HP:0011100)2.31598173
57Anteriorly placed anus (HP:0001545)2.27384382
58Absent septum pellucidum (HP:0001331)2.25648506
59Vaginal atresia (HP:0000148)2.24580597
60Decreased lacrimation (HP:0000633)2.23890252
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22560839
62Pancreatic cysts (HP:0001737)2.22151480
63Genital tract atresia (HP:0001827)2.20280287
64Pancreatic fibrosis (HP:0100732)2.20170411
65Lower limb muscle weakness (HP:0007340)2.19760937
66Patchy hypopigmentation of hair (HP:0011365)2.19633252
67Papillary thyroid carcinoma (HP:0002895)2.18752597
68Congenital ichthyosiform erythroderma (HP:0007431)2.17360272
69White forelock (HP:0002211)2.17317955
70Oligodactyly (hands) (HP:0001180)2.16959612
71Specific learning disability (HP:0001328)2.15838387
72CNS hypomyelination (HP:0003429)2.15749412
73Progressive macrocephaly (HP:0004481)2.15452241
74Aplasia involving bones of the extremities (HP:0009825)2.14685417
75Aplasia involving bones of the upper limbs (HP:0009823)2.14685417
76Aplasia of the phalanges of the hand (HP:0009802)2.14685417
77Stridor (HP:0010307)2.12524285
78Colon cancer (HP:0003003)2.12316048
79Postaxial hand polydactyly (HP:0001162)2.11536575
80Abnormal eating behavior (HP:0100738)2.11266687
81Cortical dysplasia (HP:0002539)2.11019035
82Abnormality of midbrain morphology (HP:0002418)2.10581551
83Molar tooth sign on MRI (HP:0002419)2.10581551
84Abnormal hair whorl (HP:0010721)2.09282033
85Methylmalonic acidemia (HP:0002912)2.08749577
86Slow saccadic eye movements (HP:0000514)2.08385236
87Segmental peripheral demyelination/remyelination (HP:0003481)2.05739728
88Dialeptic seizures (HP:0011146)2.03326968
89Progressive inability to walk (HP:0002505)2.02188049
90Inability to walk (HP:0002540)2.02178734
91Abnormal mitochondria in muscle tissue (HP:0008316)2.01921533
92Gait imbalance (HP:0002141)1.98750964
93Abnormality of the astrocytes (HP:0100707)1.98582978
94Astrocytoma (HP:0009592)1.98582978
95Mitochondrial inheritance (HP:0001427)1.98388061
96Nephronophthisis (HP:0000090)1.98117369
97Gaze-evoked nystagmus (HP:0000640)1.98075433
98Action tremor (HP:0002345)1.97352904
99Split foot (HP:0001839)1.96301869
100Lissencephaly (HP:0001339)1.95159081
101Abnormality of the septum pellucidum (HP:0007375)1.93827347
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.93823722
103Medial flaring of the eyebrow (HP:0010747)1.93228259
104Morphological abnormality of the pyramidal tract (HP:0002062)1.93051215
105Hypoplasia of the iris (HP:0007676)1.91446950
106Morphological abnormality of the inner ear (HP:0011390)1.90857862
107Poor speech (HP:0002465)1.89065218
108Broad foot (HP:0001769)1.88534273
109Limb dystonia (HP:0002451)1.88511112
110Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88482352
111Glioma (HP:0009733)1.88292358
112Progressive cerebellar ataxia (HP:0002073)1.87842503
113Renal cortical cysts (HP:0000803)1.86825432
114Hypomagnesemia (HP:0002917)1.86672235
115Dysdiadochokinesis (HP:0002075)1.85860054
116Renal Fanconi syndrome (HP:0001994)1.85767252
1173-Methylglutaconic aciduria (HP:0003535)1.85743983
118Cupped ear (HP:0000378)1.85291809
119Megalencephaly (HP:0001355)1.85127383
120Impaired vibration sensation in the lower limbs (HP:0002166)1.84168779
121Premature skin wrinkling (HP:0100678)1.84054670
122Diplopia (HP:0000651)1.81365325
123Abnormality of binocular vision (HP:0011514)1.81365325
124Optic nerve hypoplasia (HP:0000609)1.81285857
125Blue irides (HP:0000635)1.81150573
126Medulloblastoma (HP:0002885)1.80870305
127Generalized myoclonic seizures (HP:0002123)1.80579507
128Median cleft lip (HP:0000161)1.79955990
129Increased circulating renin level (HP:0000848)1.79738405
130Foot dorsiflexor weakness (HP:0009027)1.79310809
131Acute encephalopathy (HP:0006846)1.78454827
132Absent speech (HP:0001344)1.78257476
133Truncal ataxia (HP:0002078)1.78141540
134Coronal craniosynostosis (HP:0004440)1.77955326
135Widely spaced teeth (HP:0000687)1.76092276
136Metabolic alkalosis (HP:0200114)1.75649881
137Absence seizures (HP:0002121)1.75369768
138Urinary urgency (HP:0000012)1.75046265
139Spastic paraparesis (HP:0002313)1.74648526
140Congenital primary aphakia (HP:0007707)1.73925574
141Postnatal microcephaly (HP:0005484)1.72671783
142Postaxial foot polydactyly (HP:0001830)1.72310709
143Abnormal lung lobation (HP:0002101)1.72010139
144Neoplasm of the peripheral nervous system (HP:0100007)1.69177011
145Neoplasm of the oral cavity (HP:0100649)1.68601894
146Poor coordination (HP:0002370)1.67920829
147Epileptiform EEG discharges (HP:0011182)1.67014060
148Thyroid carcinoma (HP:0002890)1.65656567
149Gonadotropin excess (HP:0000837)1.65313633
150Renal hypoplasia (HP:0000089)1.64591921
151Abnormality of the renal medulla (HP:0100957)1.64154039
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63285208
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.61889693
154Neoplasm of the small intestine (HP:0100833)1.60168106
155Oligodactyly (HP:0012165)1.59974435
156Narrow forehead (HP:0000341)1.58888485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.21475692
2OXSR14.22196318
3CASK3.75782159
4CDK192.71901426
5TRIM282.55021556
6BCR2.53275409
7PKN12.27040528
8PBK2.20546265
9TNIK2.19694367
10MAPKAPK52.16511754
11EPHB12.09380427
12EPHA42.08985195
13FRK2.00114748
14WNK31.98060203
15WEE11.96359428
16PNCK1.96352014
17LIMK11.93664697
18FGFR21.89102854
19ERBB31.84633264
20WNK41.83759366
21MAP4K21.82110092
22MKNK21.64758214
23UHMK11.60314590
24MET1.56294479
25NEK61.55082599
26NTRK11.55037580
27CAMK2B1.53172991
28MST41.52781978
29PRPF4B1.52224097
30WNK11.49849854
31NEK11.47453078
32ROCK21.43410673
33PLK21.41388963
34CSNK1G31.40819559
35EIF2AK31.40083386
36FGR1.37850944
37TESK21.35172723
38PINK11.31214149
39CSNK1A1L1.29664221
40MARK11.28034742
41PLK31.23248020
42PAK61.22624006
43NTRK31.21032559
44NUAK11.20838973
45TSSK61.20114734
46CAMK2D1.18767468
47SGK2231.17752812
48SGK4941.17752812
49BMPR1B1.17533218
50CSNK1G21.17210471
51CLK11.09308630
52MAP2K71.06447023
53SIK31.06356421
54CAMK2A1.05987596
55MAP3K41.05247930
56PLK41.04950917
57EIF2AK11.03472671
58MAPK131.02756772
59BUB11.01096103
60ACVR1B1.00077487
61CSNK1G10.99829823
62CDK50.99796606
63CDK140.97947262
64KSR10.96770737
65ARAF0.96447720
66SRPK10.96221054
67TYRO30.96217413
68STK38L0.94689984
69PRKD30.89742720
70PRKCE0.89522719
71MAP3K120.89437484
72CDK150.87118911
73CDK180.87039975
74CAMK2G0.86150690
75PTK2B0.84875397
76PRKCQ0.84170518
77PAK30.83544738
78BMPR20.82910572
79MUSK0.82289310
80NTRK20.78006677
81DYRK20.76784200
82FES0.76780794
83CDK11A0.76424307
84GRK50.74461265
85VRK10.69265293
86MINK10.66083044
87PIK3CA0.64854756
88CAMKK20.64157854
89ADRBK20.63048565
90EIF2AK20.62186765
91MKNK10.60855437
92EPHA30.56628146
93FYN0.56335428
94PHKG20.54349055
95PHKG10.54349055
96DAPK20.53293785
97BRSK20.52661237
98GRK10.52619020
99MARK20.52091922
100PRKG10.52029301
101NME10.51135646
102RPS6KA40.50707594
103GRK70.49515828
104TAF10.49243373
105TTK0.48523912
106PRKCG0.48368179
107ERBB40.48335819
108MAP3K90.47039343
109PLK10.46130679
110RIPK40.45875254
111PDPK10.45092966
112PRKD10.44406708
113IRAK20.43881444
114AKT30.42567211
115DAPK10.41517835
116DYRK1A0.41200803
117SGK20.40858933
118PRKACB0.40526644
119CSNK1A10.40094613
120MAP3K130.39634062
121BRSK10.38790893
122PRKCH0.37588143
123ERBB20.36954404
124DAPK30.35963212
125MYLK0.35558489
126MAPK70.34286761
127CCNB10.34052686
128PRKACA0.33930100
129TRPM70.33843806
130INSRR0.33729916
131YES10.33158094
132FGFR10.32369825
133KSR20.32280877
134ADRBK10.32094976
135SGK10.31623093
136INSR0.31521473
137ROCK10.30656869
138CSNK1D0.30370196
139CDK30.28761727

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.29830767
2Steroid biosynthesis_Homo sapiens_hsa001003.37313477
3Fatty acid elongation_Homo sapiens_hsa000623.17554482
4Oxidative phosphorylation_Homo sapiens_hsa001902.67211517
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60270517
6Ether lipid metabolism_Homo sapiens_hsa005652.44470611
7Collecting duct acid secretion_Homo sapiens_hsa049662.22400830
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21574024
9Nicotine addiction_Homo sapiens_hsa050332.17871373
10Propanoate metabolism_Homo sapiens_hsa006402.15973118
11Proteasome_Homo sapiens_hsa030502.13307209
12GABAergic synapse_Homo sapiens_hsa047271.99924689
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99593107
14Glutamatergic synapse_Homo sapiens_hsa047241.99368648
15Parkinsons disease_Homo sapiens_hsa050121.90201684
16Axon guidance_Homo sapiens_hsa043601.88144484
17Morphine addiction_Homo sapiens_hsa050321.87490257
18Synaptic vesicle cycle_Homo sapiens_hsa047211.86567675
19Serotonergic synapse_Homo sapiens_hsa047261.84734839
20Alzheimers disease_Homo sapiens_hsa050101.81780244
21Protein export_Homo sapiens_hsa030601.77665783
22Vibrio cholerae infection_Homo sapiens_hsa051101.73205260
23Oocyte meiosis_Homo sapiens_hsa041141.67430490
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65066633
25Long-term depression_Homo sapiens_hsa047301.63607462
26Circadian entrainment_Homo sapiens_hsa047131.57394418
27Fanconi anemia pathway_Homo sapiens_hsa034601.54408174
28Basal transcription factors_Homo sapiens_hsa030221.51571532
29Non-homologous end-joining_Homo sapiens_hsa034501.48749721
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46075075
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40968485
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37508220
33Mismatch repair_Homo sapiens_hsa034301.36969907
34Sphingolipid metabolism_Homo sapiens_hsa006001.35474280
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34067681
36Dopaminergic synapse_Homo sapiens_hsa047281.33635189
37Rheumatoid arthritis_Homo sapiens_hsa053231.32203084
38Salivary secretion_Homo sapiens_hsa049701.30237432
39Amphetamine addiction_Homo sapiens_hsa050311.27064990
40Nitrogen metabolism_Homo sapiens_hsa009101.22483275
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20492366
42Long-term potentiation_Homo sapiens_hsa047201.19972568
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15373343
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13574360
45Cardiac muscle contraction_Homo sapiens_hsa042601.13364044
46Cocaine addiction_Homo sapiens_hsa050301.10943627
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10542819
48Cholinergic synapse_Homo sapiens_hsa047251.10372084
49Sulfur metabolism_Homo sapiens_hsa009201.08461330
50Huntingtons disease_Homo sapiens_hsa050161.08250206
51Renin secretion_Homo sapiens_hsa049241.07554858
52Circadian rhythm_Homo sapiens_hsa047101.06764365
53Taste transduction_Homo sapiens_hsa047421.06628936
54Gastric acid secretion_Homo sapiens_hsa049711.06508021
55Homologous recombination_Homo sapiens_hsa034401.04029603
56Phototransduction_Homo sapiens_hsa047441.03683574
57RNA degradation_Homo sapiens_hsa030181.03497260
58Olfactory transduction_Homo sapiens_hsa047400.99657014
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99617415
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.99005216
61Renal cell carcinoma_Homo sapiens_hsa052110.98174324
62Phagosome_Homo sapiens_hsa041450.94018337
63beta-Alanine metabolism_Homo sapiens_hsa004100.92094107
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.91233100
65Autoimmune thyroid disease_Homo sapiens_hsa053200.88415131
66Regulation of autophagy_Homo sapiens_hsa041400.86546662
67Nucleotide excision repair_Homo sapiens_hsa034200.86283583
68Vitamin B6 metabolism_Homo sapiens_hsa007500.85846568
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85005981
70Ras signaling pathway_Homo sapiens_hsa040140.84990791
71Linoleic acid metabolism_Homo sapiens_hsa005910.84210906
72RNA polymerase_Homo sapiens_hsa030200.81855313
73Oxytocin signaling pathway_Homo sapiens_hsa049210.80604405
74Gap junction_Homo sapiens_hsa045400.80567491
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77468554
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77394018
77Calcium signaling pathway_Homo sapiens_hsa040200.76517267
78Hippo signaling pathway_Homo sapiens_hsa043900.73933338
79Tight junction_Homo sapiens_hsa045300.73742816
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72831063
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71484982
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70910476
83ErbB signaling pathway_Homo sapiens_hsa040120.69492553
84Endocytosis_Homo sapiens_hsa041440.68065600
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.66318319
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65373781
87cAMP signaling pathway_Homo sapiens_hsa040240.64062657
88Insulin secretion_Homo sapiens_hsa049110.62982015
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62020222
90Histidine metabolism_Homo sapiens_hsa003400.61484912
91Ovarian steroidogenesis_Homo sapiens_hsa049130.61131104
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60364031
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56851346
94Pancreatic secretion_Homo sapiens_hsa049720.56657687
95Cell cycle_Homo sapiens_hsa041100.53280461
96TGF-beta signaling pathway_Homo sapiens_hsa043500.52510779
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51603674
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49721079
99Butanoate metabolism_Homo sapiens_hsa006500.49237179
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49099399
101Arachidonic acid metabolism_Homo sapiens_hsa005900.48355488
102Purine metabolism_Homo sapiens_hsa002300.47808020
103Peroxisome_Homo sapiens_hsa041460.47745895
104Melanogenesis_Homo sapiens_hsa049160.47121732
105MAPK signaling pathway_Homo sapiens_hsa040100.46531848
106Dorso-ventral axis formation_Homo sapiens_hsa043200.46431029
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45544889
108GnRH signaling pathway_Homo sapiens_hsa049120.45357199
109Alcoholism_Homo sapiens_hsa050340.45206537
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43135723
111Dilated cardiomyopathy_Homo sapiens_hsa054140.42990695
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42440273
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41071955
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40922660
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39694268
116ECM-receptor interaction_Homo sapiens_hsa045120.39455464
117Folate biosynthesis_Homo sapiens_hsa007900.38926103
118Choline metabolism in cancer_Homo sapiens_hsa052310.38138009
119Pyruvate metabolism_Homo sapiens_hsa006200.37204453
120Hedgehog signaling pathway_Homo sapiens_hsa043400.36841680
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36528674
122Rap1 signaling pathway_Homo sapiens_hsa040150.35996461
123Glioma_Homo sapiens_hsa052140.35743057
124Estrogen signaling pathway_Homo sapiens_hsa049150.35364013
125Arginine and proline metabolism_Homo sapiens_hsa003300.34374554
126Salmonella infection_Homo sapiens_hsa051320.33626095
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33455806
128Mineral absorption_Homo sapiens_hsa049780.32810558
129Chemokine signaling pathway_Homo sapiens_hsa040620.32331636
130Lysosome_Homo sapiens_hsa041420.31840706
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31028613
132RNA transport_Homo sapiens_hsa030130.30953487
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30928246
134Wnt signaling pathway_Homo sapiens_hsa043100.30920384
135Spliceosome_Homo sapiens_hsa030400.30078987
136African trypanosomiasis_Homo sapiens_hsa051430.29144564
137Allograft rejection_Homo sapiens_hsa053300.28661772

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