SEPT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.13794676
2negative regulation of cell killing (GO:0031342)6.13794676
3positive regulation of gamma-delta T cell activation (GO:0046645)5.74055689
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.05381360
5response to interleukin-15 (GO:0070672)4.94988496
6negative T cell selection (GO:0043383)4.92368585
7cellular response to interleukin-15 (GO:0071350)4.72966205
8regulation of gamma-delta T cell differentiation (GO:0045586)4.70877937
9negative thymic T cell selection (GO:0045060)4.67553234
10positive T cell selection (GO:0043368)4.49450190
11regulation of B cell receptor signaling pathway (GO:0050855)4.37469084
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36726697
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36726697
14positive thymic T cell selection (GO:0045059)4.29395173
15regulation of gamma-delta T cell activation (GO:0046643)4.22630283
16antigen processing and presentation of endogenous antigen (GO:0019883)4.09070127
17T cell selection (GO:0045058)4.02747451
18mast cell activation (GO:0045576)3.99437409
19immunoglobulin mediated immune response (GO:0016064)3.93605903
20thymic T cell selection (GO:0045061)3.86773616
21B cell receptor signaling pathway (GO:0050853)3.84342988
22interferon-gamma production (GO:0032609)3.82309040
23regulation of isotype switching to IgG isotypes (GO:0048302)3.78672353
24mast cell degranulation (GO:0043303)3.68262572
25mast cell activation involved in immune response (GO:0002279)3.68262572
26ribosomal small subunit assembly (GO:0000028)3.64415741
27T cell receptor signaling pathway (GO:0050852)3.64190829
28T cell homeostasis (GO:0043029)3.64160329
29antigen receptor-mediated signaling pathway (GO:0050851)3.59404797
30regulation of granulocyte differentiation (GO:0030852)3.52643340
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.48288287
32T cell costimulation (GO:0031295)3.46216439
33positive regulation by symbiont of host defense response (GO:0052509)3.43884070
34modulation by symbiont of host defense response (GO:0052031)3.43884070
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43884070
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43884070
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.43884070
38modulation by symbiont of host immune response (GO:0052553)3.43884070
39neutrophil activation involved in immune response (GO:0002283)3.43862320
40lymphocyte costimulation (GO:0031294)3.43751927
41regulation of interleukin-2 biosynthetic process (GO:0045076)3.39511058
42B cell mediated immunity (GO:0019724)3.39321255
43response to muramyl dipeptide (GO:0032495)3.39000223
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37291009
45regulation of B cell differentiation (GO:0045577)3.36353158
46V(D)J recombination (GO:0033151)3.29943626
47regulation of regulatory T cell differentiation (GO:0045589)3.27967713
48B cell homeostasis (GO:0001782)3.26817933
49detection of bacterium (GO:0016045)3.24128785
50T cell migration (GO:0072678)3.23133918
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20165894
52regulation of T cell receptor signaling pathway (GO:0050856)3.18358927
53cellular extravasation (GO:0045123)3.15048259
54positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.12708289
55negative regulation of leukocyte mediated immunity (GO:0002704)3.11583266
56positive regulation of B cell activation (GO:0050871)3.06820420
57viral transcription (GO:0019083)3.06402315
58detection of other organism (GO:0098543)3.04856232
59positive regulation of B cell differentiation (GO:0045579)3.04700238
60leukocyte aggregation (GO:0070486)3.03618839
61Peyers patch development (GO:0048541)3.02217717
62mucosal-associated lymphoid tissue development (GO:0048537)3.02217717
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99350668
64cellular response to type I interferon (GO:0071357)2.99052505
65type I interferon signaling pathway (GO:0060337)2.99052505
66positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98095121
67activated T cell proliferation (GO:0050798)2.98079372
68response to type I interferon (GO:0034340)2.97944102
69negative regulation of T cell mediated immunity (GO:0002710)2.96382001
70interferon-gamma-mediated signaling pathway (GO:0060333)2.95639669
71regulation of alpha-beta T cell activation (GO:0046634)2.93863306
72defense response to protozoan (GO:0042832)2.92414621
73lymphocyte homeostasis (GO:0002260)2.91949574
74germinal center formation (GO:0002467)2.91102346
75translational termination (GO:0006415)2.90590360
76T cell differentiation (GO:0030217)2.89363860
77positive regulation of granulocyte differentiation (GO:0030854)2.89322681
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89222381
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88668609
80regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88526052
81alternative mRNA splicing, via spliceosome (GO:0000380)2.88494915
82positive regulation of alpha-beta T cell differentiation (GO:0046638)2.86442619
83response to protozoan (GO:0001562)2.85826720
84positive regulation of alpha-beta T cell activation (GO:0046635)2.85707027
85positive regulation of interleukin-4 production (GO:0032753)2.85190371
86regulation of antigen processing and presentation (GO:0002577)2.83806429
87antigen processing and presentation via MHC class Ib (GO:0002475)2.83546565
88negative regulation of lymphocyte mediated immunity (GO:0002707)2.83176859
89regulation of natural killer cell mediated immunity (GO:0002715)2.82474797
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82474797
91megakaryocyte development (GO:0035855)2.80222144
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80106585
93regulation of defense response to virus by virus (GO:0050690)2.79997897
94DNA unwinding involved in DNA replication (GO:0006268)2.79878452
95regulation of interleukin-4 production (GO:0032673)2.79783490
96positive regulation of natural killer cell mediated immunity (GO:0002717)2.78876425
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.78876425
98positive regulation of T cell differentiation (GO:0045582)2.78236971
99immune response-activating cell surface receptor signaling pathway (GO:0002429)2.76973181
100regulation of B cell activation (GO:0050864)2.76372663
101response to host immune response (GO:0052572)2.76314899
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76314899
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73911418
104regulation of T cell tolerance induction (GO:0002664)2.68155207
105negative regulation of phagocytosis (GO:0050765)2.63953045
106positive regulation of interleukin-2 production (GO:0032743)2.61943070
107regulation of alpha-beta T cell proliferation (GO:0046640)2.61860119
108negative regulation of T cell receptor signaling pathway (GO:0050860)2.60506765
109positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.60408205
110leukocyte homeostasis (GO:0001776)2.60131285
111natural killer cell differentiation (GO:0001779)2.57039370
112translational elongation (GO:0006414)2.56112070
113positive regulation of lamellipodium assembly (GO:0010592)2.55990518
114lymph node development (GO:0048535)2.54019248
115myeloid dendritic cell activation (GO:0001773)2.53545065
116T cell activation (GO:0042110)2.51796841
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.51589486
118definitive hemopoiesis (GO:0060216)2.50722786
119cellular response to interleukin-4 (GO:0071353)2.49435128
120tolerance induction (GO:0002507)2.48092484
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.47314185
122natural killer cell activation (GO:0030101)2.45849634
123mature B cell differentiation (GO:0002335)2.45346948
124regulation of leukocyte mediated cytotoxicity (GO:0001910)2.45277278
125alpha-beta T cell activation (GO:0046631)2.44928282
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.44713404
127regulation of response to interferon-gamma (GO:0060330)2.42692108
128cellular protein complex disassembly (GO:0043624)2.41962328
129ribosomal small subunit biogenesis (GO:0042274)2.41594954
130regulation of T cell mediated cytotoxicity (GO:0001914)2.41397233
131positive regulation of isotype switching (GO:0045830)2.40849459
132negative regulation of RNA splicing (GO:0033119)2.40590719
133negative regulation of erythrocyte differentiation (GO:0045647)2.40447966
134regulation of isotype switching (GO:0045191)2.40280208
135telomere maintenance via semi-conservative replication (GO:0032201)2.39095785
136negative regulation of adaptive immune response (GO:0002820)2.38512088
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.36489239
138positive regulation of alpha-beta T cell proliferation (GO:0046641)2.35768014
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.35610086
140T cell proliferation (GO:0042098)2.34536681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75700829
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.86910154
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74274410
4MYC_22102868_ChIP-Seq_BL_Human3.97242152
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.24602483
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23258419
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03937421
8MYB_26560356_Chip-Seq_TH2_Human2.80400024
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80354761
10RUNX_20019798_ChIP-Seq_JUKART_Human2.75609755
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74844040
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.64607335
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54966297
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52048337
15SCL_19346495_ChIP-Seq_HPC-7_Human2.49355103
16VDR_21846776_ChIP-Seq_THP-1_Human2.49156007
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45250386
18MAF_26560356_Chip-Seq_TH1_Human2.39735873
19CIITA_25753668_ChIP-Seq_RAJI_Human2.34781039
20UTX_26944678_Chip-Seq_JUKART_Human2.31830353
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31170690
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15674424
23MYB_26560356_Chip-Seq_TH1_Human2.13770953
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.12325595
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09665670
26TCF7_22412390_ChIP-Seq_EML_Mouse1.94895030
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91564254
28EZH2_22144423_ChIP-Seq_EOC_Human1.89165694
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87613424
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86860636
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80667675
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.77906933
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.77491825
34SPI1_23547873_ChIP-Seq_NB4_Human1.77101342
35VDR_24763502_ChIP-Seq_THP-1_Human1.75041674
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73168113
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70097060
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67521751
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.66018812
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.61575865
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61134891
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60526673
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57628247
44GATA3_27048872_Chip-Seq_THYMUS_Human1.56936063
45FOXP3_21729870_ChIP-Seq_TREG_Human1.54136068
46MAF_26560356_Chip-Seq_TH2_Human1.54069960
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.53898618
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53511544
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49776301
50GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49162501
51KDM2B_26808549_Chip-Seq_DND41_Human1.47290427
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47137984
53SPI1_23127762_ChIP-Seq_K562_Human1.46780763
54VDR_23849224_ChIP-Seq_CD4+_Human1.45481919
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41064595
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38815528
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38728324
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35827238
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35747836
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35221208
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34900574
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.34710455
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31776650
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28669534
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26084208
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24702291
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23468203
68XRN2_22483619_ChIP-Seq_HELA_Human1.23250723
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22833208
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.20368055
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19191698
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.18616595
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14778379
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13626549
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.12699992
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12435843
77BCL6_27268052_Chip-Seq_Bcells_Human1.11778063
78GATA1_19941826_ChIP-Seq_K562_Human1.11606291
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11235412
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10806507
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.10048596
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09838576
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09823617
84GATA1_22025678_ChIP-Seq_K562_Human1.08536253
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08212996
86VDR_24787735_ChIP-Seq_THP-1_Human1.06373339
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.05021909
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04534187
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.04375415
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04237857
91NCOR1_26117541_ChIP-Seq_K562_Human1.03536784
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01947953
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00583905
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99883139
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.98095330
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97295129
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95706205
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95571305
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94005967
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93413498
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91542135
102P300_27268052_Chip-Seq_Bcells_Human0.91324427
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91123769
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.90543550
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89477310
106SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88988413
107BCOR_27268052_Chip-Seq_Bcells_Human0.88704878
108GATA3_26560356_Chip-Seq_TH2_Human0.88120106
109ELK1_19687146_ChIP-ChIP_HELA_Human0.87007852
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86257162
111ETS1_20019798_ChIP-Seq_JURKAT_Human0.85569752
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84724367
113GATA2_19941826_ChIP-Seq_K562_Human0.84343422
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.83733187
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83336699
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81928114
117TTF2_22483619_ChIP-Seq_HELA_Human0.81491665
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80555991
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80333501
120GABP_17652178_ChIP-ChIP_JURKAT_Human0.80093218
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79909623
122SPI1_20517297_ChIP-Seq_HL60_Human0.79316862
123PU_27001747_Chip-Seq_BMDM_Mouse0.78961334
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78841202
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78779512
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78262139
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.77181959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.94426052
2MP0005671_abnormal_response_to3.40628259
3MP0001835_abnormal_antigen_presentation3.31893999
4MP0000685_abnormal_immune_system3.03656455
5MP0002396_abnormal_hematopoietic_system2.96127424
6MP0001800_abnormal_humoral_immune2.89690599
7MP0003724_increased_susceptibility_to2.89030073
8MP0002398_abnormal_bone_marrow2.77583117
9MP0004859_abnormal_synaptic_plasticity2.53636642
10MP0000703_abnormal_thymus_morphology2.51765136
11MP0002420_abnormal_adaptive_immunity2.46599645
12MP0001819_abnormal_immune_cell2.42428826
13MP0004808_abnormal_hematopoietic_stem2.37384339
14MP0002166_altered_tumor_susceptibility2.29895007
15MP0002723_abnormal_immune_serum2.29255527
16MP0001790_abnormal_immune_system2.27628588
17MP0005387_immune_system_phenotype2.27628588
18MP0002452_abnormal_antigen_presenting2.26475971
19MP0003880_abnormal_central_pattern2.24275009
20MP0000716_abnormal_immune_system2.23459010
21MP0005000_abnormal_immune_tolerance2.12012474
22MP0002722_abnormal_immune_system2.11449666
23MP0000689_abnormal_spleen_morphology2.05928740
24MP0003866_abnormal_defecation1.90925288
25MP0009785_altered_susceptibility_to1.90820159
26MP0002429_abnormal_blood_cell1.87238066
27MP0002006_tumorigenesis1.84442301
28MP0003787_abnormal_imprinting1.81149756
29MP0009333_abnormal_splenocyte_physiolog1.78499975
30MP0005174_abnormal_tail_pigmentation1.77924337
31MP0005025_abnormal_response_to1.76387372
32MP0003635_abnormal_synaptic_transmissio1.71731495
33MP0001968_abnormal_touch/_nociception1.70976781
34MP0010094_abnormal_chromosome_stability1.61675238
35MP0001873_stomach_inflammation1.58257864
36MP0002405_respiratory_system_inflammati1.57485474
37MP0002735_abnormal_chemical_nociception1.54719308
38MP0010155_abnormal_intestine_physiology1.49696870
39MP0003303_peritoneal_inflammation1.44312255
40MP0001986_abnormal_taste_sensitivity1.39920402
41MP0005464_abnormal_platelet_physiology1.38865001
42MP0009745_abnormal_behavioral_response1.38856994
43MP0000015_abnormal_ear_pigmentation1.38703723
44MP0004510_myositis1.37474817
45MP0008057_abnormal_DNA_replication1.36456836
46MP0002148_abnormal_hypersensitivity_rea1.35117163
47MP0002736_abnormal_nociception_after1.34957891
48MP0002138_abnormal_hepatobiliary_system1.31635968
49MP0008877_abnormal_DNA_methylation1.31576948
50MP0008569_lethality_at_weaning1.29453812
51MP0004381_abnormal_hair_follicle1.27866233
52MP0002095_abnormal_skin_pigmentation1.25415387
53MP0005423_abnormal_somatic_nervous1.25415036
54MP0002063_abnormal_learning/memory/cond1.24882233
55MP0002419_abnormal_innate_immunity1.18141589
56MP0002132_abnormal_respiratory_system1.15406172
57MP0005397_hematopoietic_system_phenotyp1.15118838
58MP0001545_abnormal_hematopoietic_system1.15118838
59MP0001533_abnormal_skeleton_physiology1.14768354
60MP0003077_abnormal_cell_cycle1.13101227
61MP0008469_abnormal_protein_level1.12271511
62MP0000490_abnormal_crypts_of1.12149556
63MP0003436_decreased_susceptibility_to1.07895059
64MP0005075_abnormal_melanosome_morpholog1.07685380
65MP0005409_darkened_coat_color1.07652712
66MP0002064_seizures1.07493288
67MP0002572_abnormal_emotion/affect_behav1.06962446
68MP0005645_abnormal_hypothalamus_physiol1.04068193
69MP0001845_abnormal_inflammatory_respons1.03027314
70MP0002019_abnormal_tumor_incidence1.02176235
71MP0003121_genomic_imprinting0.97980884
72MP0009764_decreased_sensitivity_to0.97311509
73MP0001851_eye_inflammation0.97088627
74MP0003300_gastrointestinal_ulcer0.96807665
75MP0000465_gastrointestinal_hemorrhage0.95542045
76MP0001853_heart_inflammation0.95007005
77MP0002009_preneoplasia0.94524884
78MP0002933_joint_inflammation0.94417966
79MP0006276_abnormal_autonomic_nervous0.92575179
80MP0004811_abnormal_neuron_physiology0.89677156
81MP0001188_hyperpigmentation0.89666949
82MP0009765_abnormal_xenobiotic_induced0.89532856
83MP0002163_abnormal_gland_morphology0.87835117
84MP0006082_CNS_inflammation0.87722488
85MP0005310_abnormal_salivary_gland0.87245372
86MP0008995_early_reproductive_senescence0.85982519
87MP0008058_abnormal_DNA_repair0.85722876
88MP0004947_skin_inflammation0.84998817
89MP0003183_abnormal_peptide_metabolism0.84866559
90MP0000858_altered_metastatic_potential0.84747995
91MP0008961_abnormal_basal_metabolism0.84010695
92MP0001663_abnormal_digestive_system0.83246765
93MP0009763_increased_sensitivity_to0.82634693
94MP0003172_abnormal_lysosome_physiology0.82508669
95MP0001970_abnormal_pain_threshold0.81593916
96MP0002184_abnormal_innervation0.81301825
97MP0002733_abnormal_thermal_nociception0.81134489
98MP0002272_abnormal_nervous_system0.79829511
99MP0002067_abnormal_sensory_capabilities0.79133612
100MP0004957_abnormal_blastocyst_morpholog0.78830629
101MP0009278_abnormal_bone_marrow0.78667573
102MP0001348_abnormal_lacrimal_gland0.77329022
103MP0009379_abnormal_foot_pigmentation0.77301536
104MP0003111_abnormal_nucleus_morphology0.76153320
105MP0008007_abnormal_cellular_replicative0.75132071
106MP0003879_abnormal_hair_cell0.73799232
107MP0009046_muscle_twitch0.71599613
108MP0003656_abnormal_erythrocyte_physiolo0.70488145
109MP0001905_abnormal_dopamine_level0.68784756
110MP0001501_abnormal_sleep_pattern0.68758757
111MP0002822_catalepsy0.68188446
112MP0000569_abnormal_digit_pigmentation0.67598149
113MP0002083_premature_death0.67508109
114MP0003693_abnormal_embryo_hatching0.67172415
115MP0002557_abnormal_social/conspecific_i0.66153769
116MP0005084_abnormal_gallbladder_morpholo0.65791460
117MP0008874_decreased_physiological_sensi0.64134538
118MP0003122_maternal_imprinting0.62332605
119MP0000350_abnormal_cell_proliferation0.62040954
120MP0000313_abnormal_cell_death0.58317493
121MP0002998_abnormal_bone_remodeling0.57469047
122MP0000372_irregular_coat_pigmentation0.55841658
123MP0002928_abnormal_bile_duct0.55564088
124MP0002693_abnormal_pancreas_physiology0.54183846
125MP0005220_abnormal_exocrine_pancreas0.54085496
126MP0005535_abnormal_body_temperature0.52251742
127MP0003252_abnormal_bile_duct0.51053063
128MP0003786_premature_aging0.50486298
129MP0008260_abnormal_autophagy0.49227829
130MP0008004_abnormal_stomach_pH0.49108742
131MP0003221_abnormal_cardiomyocyte_apopto0.47515690
132MP0000249_abnormal_blood_vessel0.47482931
133MP0003828_pulmonary_edema0.46382760
134MP0000598_abnormal_liver_morphology0.42867896
135MP0009642_abnormal_blood_homeostasis0.42536564
136MP0003045_fibrosis0.42356064
137MP0004130_abnormal_muscle_cell0.42062822
138MP0005451_abnormal_body_composition0.38351496
139MP0005381_digestive/alimentary_phenotyp0.37927056

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.74296372
2T lymphocytopenia (HP:0005403)4.71553997
3Abnormality of T cell number (HP:0011839)4.42898047
4IgM deficiency (HP:0002850)4.21233391
5Eczematoid dermatitis (HP:0000976)4.16659660
6Agammaglobulinemia (HP:0004432)4.15323905
7B lymphocytopenia (HP:0010976)4.14182188
8Abnormality of B cell number (HP:0010975)4.14182188
9Recurrent bronchitis (HP:0002837)4.09466747
10Recurrent viral infections (HP:0004429)3.99055352
11Chronic otitis media (HP:0000389)3.75823706
12Abnormality of T cells (HP:0002843)3.75299578
13Thyroiditis (HP:0100646)3.67264499
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.67158994
15Increased IgE level (HP:0003212)3.56336510
16Severe combined immunodeficiency (HP:0004430)3.53488561
17IgG deficiency (HP:0004315)3.48599781
18Thrombocytosis (HP:0001894)3.37778274
19Increased IgM level (HP:0003496)3.35066231
20Elevated erythrocyte sedimentation rate (HP:0003565)3.34133099
21Spontaneous hematomas (HP:0007420)3.33362406
22Recurrent fungal infections (HP:0002841)3.30504592
23Myositis (HP:0100614)3.19744043
24Chronic mucocutaneous candidiasis (HP:0002728)3.17114674
25Recurrent cutaneous fungal infections (HP:0011370)3.17114674
26Epistaxis (HP:0000421)3.12312895
27Combined immunodeficiency (HP:0005387)3.06414397
28Meningitis (HP:0001287)3.06376720
29Gastrointestinal infarctions (HP:0005244)2.92067491
30Lymphopenia (HP:0001888)2.89530725
31Retrobulbar optic neuritis (HP:0100654)2.89234595
32Optic neuritis (HP:0100653)2.89234595
33Orchitis (HP:0100796)2.82467862
34Autoimmune thrombocytopenia (HP:0001973)2.80640497
35Papilloma (HP:0012740)2.80000800
36Verrucae (HP:0200043)2.80000800
37Abnormality of the prostate (HP:0008775)2.79806009
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.76228105
39Nasal polyposis (HP:0100582)2.73484327
40Gastrointestinal inflammation (HP:0004386)2.67528879
41Petechiae (HP:0000967)2.66748563
42Abnormality of macrophages (HP:0004311)2.63609694
43Abnormality of the fingertips (HP:0001211)2.63409931
44Volvulus (HP:0002580)2.62866828
45Hypergammaglobulinemia (HP:0010702)2.62077363
46Inflammation of the large intestine (HP:0002037)2.58474498
47Chronic sinusitis (HP:0011109)2.56442309
48Pulmonary infiltrates (HP:0002113)2.55375614
49Urticaria (HP:0001025)2.55002007
50Abnormality of T cell physiology (HP:0011840)2.54718882
51Aplasia/Hypoplasia of the thymus (HP:0010515)2.54646558
52Papilledema (HP:0001085)2.53140809
53Pustule (HP:0200039)2.51875903
54Osteomyelitis (HP:0002754)2.49830890
55Abnormality of eosinophils (HP:0001879)2.47420588
56Amyotrophic lateral sclerosis (HP:0007354)2.45957238
57Focal motor seizures (HP:0011153)2.41855136
58Gastrointestinal stroma tumor (HP:0100723)2.41761564
59Recurrent sinusitis (HP:0011108)2.41609330
60Gingival bleeding (HP:0000225)2.40405914
61Cellulitis (HP:0100658)2.37137275
62Lymphoma (HP:0002665)2.33118617
63Abnormality of cells of the erythroid lineage (HP:0012130)2.32539458
64Abnormal number of erythroid precursors (HP:0012131)2.28713719
65Hyperacusis (HP:0010780)2.27554342
66Hypochromic anemia (HP:0001931)2.27194554
67Abnormality of the nasal mucosa (HP:0000433)2.26582263
68Skin rash (HP:0000988)2.26011037
69Colitis (HP:0002583)2.25824914
70Basal cell carcinoma (HP:0002671)2.24606983
71Hemoptysis (HP:0002105)2.20459232
72Hypoplasia of the thymus (HP:0000778)2.18578062
73Pulmonary embolism (HP:0002204)2.17817967
74Eosinophilia (HP:0001880)2.16520635
75Encephalitis (HP:0002383)2.15285665
76Keratoconjunctivitis sicca (HP:0001097)2.15223207
77Recurrent lower respiratory tract infections (HP:0002783)2.14537121
78Bronchitis (HP:0012387)2.13248741
79Mediastinal lymphadenopathy (HP:0100721)2.12967565
80Recurrent gram-negative bacterial infections (HP:0005420)2.11701126
81IgA deficiency (HP:0002720)2.10998376
82Amaurosis fugax (HP:0100576)2.09252619
83Acute lymphatic leukemia (HP:0006721)2.08465222
84Visual hallucinations (HP:0002367)2.07051347
85Chest pain (HP:0100749)2.04372755
86Vasculitis (HP:0002633)2.02812054
87Aplastic anemia (HP:0001915)2.02790054
88Acute hepatic failure (HP:0006554)2.02416238
89Purpura (HP:0000979)2.01874853
90Recurrent abscess formation (HP:0002722)2.00943931
91Joint swelling (HP:0001386)2.00566383
92Autoimmune hemolytic anemia (HP:0001890)2.00553473
93Keratoconjunctivitis (HP:0001096)2.00237743
94Abnormality of the pleura (HP:0002103)1.97408530
95Hypochromic microcytic anemia (HP:0004840)1.96744974
96Recurrent pneumonia (HP:0006532)1.95757341
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.95608648
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93320973
99Microcytic anemia (HP:0001935)1.93135068
100Viral hepatitis (HP:0006562)1.92908091
101Abnormality of male internal genitalia (HP:0000022)1.91571679
102Abnormal hair whorl (HP:0010721)1.91062545
103Chronic obstructive pulmonary disease (HP:0006510)1.89092507
104Obstructive lung disease (HP:0006536)1.89092507
105Atonic seizures (HP:0010819)1.88471794
106Muscle fiber atrophy (HP:0100295)1.85432930
107Chronic diarrhea (HP:0002028)1.85341239
108Leukocytosis (HP:0001974)1.85317251
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.84891034
110Granulocytopenia (HP:0001913)1.84718043
111Recurrent skin infections (HP:0001581)1.84420039
112Impaired smooth pursuit (HP:0007772)1.83680161
113Broad palm (HP:0001169)1.78864410
114Spinal canal stenosis (HP:0003416)1.78727064
115Stomatitis (HP:0010280)1.73479438
116Diplopia (HP:0000651)1.72837341
117Abnormality of binocular vision (HP:0011514)1.72837341
118Focal seizures (HP:0007359)1.72604981
119Prolonged bleeding time (HP:0003010)1.72171603
120Inappropriate behavior (HP:0000719)1.71662076
121Hypoproteinemia (HP:0003075)1.71101516
122Type 2 muscle fiber atrophy (HP:0003554)1.70837834
123Recurrent bacterial skin infections (HP:0005406)1.70311605
124Progressive inability to walk (HP:0002505)1.69272006
125Pointed chin (HP:0000307)1.69060440
126Febrile seizures (HP:0002373)1.68599115
127Cutis marmorata (HP:0000965)1.66641760
128Sacral dimple (HP:0000960)1.66521814
129Truncal ataxia (HP:0002078)1.64828200
130Increased nuchal translucency (HP:0010880)1.63916349
131Acute myeloid leukemia (HP:0004808)1.63582494
132Colon cancer (HP:0003003)1.62123425
133Reticulocytopenia (HP:0001896)1.61348244
134Optic nerve coloboma (HP:0000588)1.60814784
135Recurrent otitis media (HP:0000403)1.60522150
136Fatigue (HP:0012378)1.60145680
137Sepsis (HP:0100806)1.59027620
138Arterial thrombosis (HP:0004420)1.58970319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.97811166
2TXK3.79421710
3TAOK33.11948461
4MAP3K122.81724866
5GRK62.77700825
6EEF2K2.77481429
7PRPF4B2.53188583
8ZAP702.40281846
9ERN12.38465738
10SYK2.32538393
11RIPK42.30658642
12SIK22.24170090
13JAK32.11081340
14ITK1.99981969
15KIT1.97632329
16MAP3K101.92927560
17CDC71.76792105
18BTK1.74470885
19MAP2K71.72089749
20FES1.67361044
21TEC1.57276933
22IRAK41.52907369
23TSSK61.49738077
24DAPK11.48354589
25LCK1.43043265
26TNK21.41377778
27CDK191.38320270
28CSF1R1.37497925
29SIK31.37354410
30TGFBR11.33440807
31MAP3K41.30418174
32NLK1.30072041
33TNIK1.26604291
34STK101.23609348
35FGFR31.17948070
36BLK1.17183239
37PKN21.15164143
38MINK11.15060008
39FLT31.14314357
40MARK11.13520658
41NTRK31.05483019
42HCK1.03933112
43IKBKE1.03744243
44TYK21.00077093
45CCNB10.98109481
46BMPR20.97140353
47MATK0.96692044
48CLK10.95386606
49JAK20.95197724
50NTRK20.93102774
51TBK10.92368747
52JAK10.91173866
53LYN0.90601669
54LRRK20.89496401
55CDK120.88836135
56ALK0.88656549
57MAP3K110.88314010
58MAPK110.83551936
59MAP3K130.83227472
60PRKCH0.80565423
61PRKCQ0.79261249
62CAMKK20.78626996
63MAP3K70.71765195
64BCKDK0.71253560
65MAPK130.69642364
66PIK3CG0.69277303
67FGFR40.66280676
68BRD40.66007318
69HIPK20.65231898
70PASK0.65132909
71ACVR1B0.65045621
72MARK20.60432570
73MAPK70.58889807
74TAOK10.58299197
75PDK10.57879522
76MAP2K20.57008121
77MAP3K90.56915366
78VRK10.56753969
79SCYL20.55033024
80MAP2K40.54226021
81CDK40.50881330
82RAF10.49850622
83RET0.49469181
84MAPK40.49266018
85MAP2K60.49093483
86MAP3K10.48491980
87CAMKK10.47615901
88KDR0.47424411
89MST40.46610710
90ATR0.45875540
91CSK0.45695818
92UHMK10.45658261
93TESK20.45017954
94EPHA30.45006432
95SMG10.44797600
96DYRK1B0.44163413
97PIM10.43882685
98MAPK30.41641520
99FYN0.41415441
100MAP3K140.41340283
101FGR0.41082414
102CDK50.41076080
103PLK20.41054842
104EPHB10.40870013
105NME20.40814276
106NEK20.40274597
107RPS6KA50.40181113
108CAMK10.39501475
109EPHA40.39282919
110IRAK10.38495215
111STK240.38305292
112RPS6KC10.38020047
113RPS6KL10.38020047
114CDK60.37728118
115BRSK10.37584399
116TAOK20.37544823
117ADRBK20.35266872
118TRIB30.35082474
119MAP2K30.35071924
120RPS6KB20.34910838
121MARK30.34765323
122RPS6KA60.33902678
123NUAK10.32919389
124STK110.32340223
125MAPK120.32233852
126YES10.31866673
127DAPK20.31857430
128MAP3K50.31673769
129MAP3K60.31526340
130IKBKB0.30280113
131MKNK20.30238294
132RPS6KA40.29600279
133ILK0.29455523
134RPS6KB10.29443185
135DYRK1A0.24429770
136IRAK20.23269616
137MAP4K20.22923504
138CDK90.21248193
139CDC42BPA0.21034848
140PRKCD0.20829062

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.87068798
2Autoimmune thyroid disease_Homo sapiens_hsa053203.36853509
3Asthma_Homo sapiens_hsa053102.95210372
4T cell receptor signaling pathway_Homo sapiens_hsa046602.33282177
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.30361264
6DNA replication_Homo sapiens_hsa030302.08128468
7B cell receptor signaling pathway_Homo sapiens_hsa046621.97198806
8Staphylococcus aureus infection_Homo sapiens_hsa051501.82755058
9Antigen processing and presentation_Homo sapiens_hsa046121.65812818
10Mismatch repair_Homo sapiens_hsa034301.58756955
11Ribosome_Homo sapiens_hsa030101.56025629
12Long-term potentiation_Homo sapiens_hsa047201.55679128
13Measles_Homo sapiens_hsa051621.49832782
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.46625884
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42541178
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39820610
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39377443
18Spliceosome_Homo sapiens_hsa030401.28101799
19Nicotine addiction_Homo sapiens_hsa050331.27995181
20Base excision repair_Homo sapiens_hsa034101.24320425
21Osteoclast differentiation_Homo sapiens_hsa043801.23911303
22Hematopoietic cell lineage_Homo sapiens_hsa046401.21487389
23Colorectal cancer_Homo sapiens_hsa052101.20484494
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.17510613
25Leishmaniasis_Homo sapiens_hsa051401.15674574
26Non-homologous end-joining_Homo sapiens_hsa034501.11879924
27Acute myeloid leukemia_Homo sapiens_hsa052211.10126048
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10122089
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.09137469
30Viral myocarditis_Homo sapiens_hsa054161.09021121
31Chemokine signaling pathway_Homo sapiens_hsa040621.08692351
32Morphine addiction_Homo sapiens_hsa050321.07374495
33Olfactory transduction_Homo sapiens_hsa047401.04901302
34Herpes simplex infection_Homo sapiens_hsa051681.04701246
35Systemic lupus erythematosus_Homo sapiens_hsa053221.04522256
36Shigellosis_Homo sapiens_hsa051311.04353674
37Dopaminergic synapse_Homo sapiens_hsa047281.01569465
38Hepatitis B_Homo sapiens_hsa051611.01368179
39Allograft rejection_Homo sapiens_hsa053301.00929319
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00037524
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99397678
42Amphetamine addiction_Homo sapiens_hsa050310.99173898
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98964234
44Circadian entrainment_Homo sapiens_hsa047130.98590250
45Rheumatoid arthritis_Homo sapiens_hsa053230.98106900
46Non-small cell lung cancer_Homo sapiens_hsa052230.98003079
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.96616733
48Platelet activation_Homo sapiens_hsa046110.95680016
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93012666
50Pancreatic cancer_Homo sapiens_hsa052120.92559718
51Glutamatergic synapse_Homo sapiens_hsa047240.91277031
52VEGF signaling pathway_Homo sapiens_hsa043700.89532170
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88933825
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88403215
55Nucleotide excision repair_Homo sapiens_hsa034200.86847046
56Graft-versus-host disease_Homo sapiens_hsa053320.85371492
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84901471
58Epstein-Barr virus infection_Homo sapiens_hsa051690.84609599
59Chronic myeloid leukemia_Homo sapiens_hsa052200.84043974
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82850789
61HTLV-I infection_Homo sapiens_hsa051660.81123314
62Gastric acid secretion_Homo sapiens_hsa049710.80721463
63Cholinergic synapse_Homo sapiens_hsa047250.80496158
64Toxoplasmosis_Homo sapiens_hsa051450.80285781
65Oxytocin signaling pathway_Homo sapiens_hsa049210.79413679
66TNF signaling pathway_Homo sapiens_hsa046680.77901170
67Salivary secretion_Homo sapiens_hsa049700.77592840
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77238557
69Influenza A_Homo sapiens_hsa051640.77193234
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77165788
71Thyroid cancer_Homo sapiens_hsa052160.76568913
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75949471
73mRNA surveillance pathway_Homo sapiens_hsa030150.75899321
74Glioma_Homo sapiens_hsa052140.75677241
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75676840
76Renin secretion_Homo sapiens_hsa049240.75462238
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75266364
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75190711
79Oocyte meiosis_Homo sapiens_hsa041140.74664896
80Apoptosis_Homo sapiens_hsa042100.74577885
81Type I diabetes mellitus_Homo sapiens_hsa049400.74310128
82Long-term depression_Homo sapiens_hsa047300.73193800
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72552930
84Cell cycle_Homo sapiens_hsa041100.72439260
85RNA degradation_Homo sapiens_hsa030180.70120069
86Synaptic vesicle cycle_Homo sapiens_hsa047210.69926532
87Malaria_Homo sapiens_hsa051440.69743529
88Estrogen signaling pathway_Homo sapiens_hsa049150.69476906
89Hepatitis C_Homo sapiens_hsa051600.68238193
90GnRH signaling pathway_Homo sapiens_hsa049120.67915385
91Prolactin signaling pathway_Homo sapiens_hsa049170.67585039
92MAPK signaling pathway_Homo sapiens_hsa040100.67184572
93Calcium signaling pathway_Homo sapiens_hsa040200.64251470
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64124011
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63712939
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.63460189
97Salmonella infection_Homo sapiens_hsa051320.63391500
98Tuberculosis_Homo sapiens_hsa051520.63301262
99African trypanosomiasis_Homo sapiens_hsa051430.61942259
100Viral carcinogenesis_Homo sapiens_hsa052030.61506452
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60620985
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60354219
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60228203
104Homologous recombination_Homo sapiens_hsa034400.60198383
105Taste transduction_Homo sapiens_hsa047420.60157609
106Endometrial cancer_Homo sapiens_hsa052130.60123186
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57115970
108GABAergic synapse_Homo sapiens_hsa047270.56971536
109Phagosome_Homo sapiens_hsa041450.56643022
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55629381
111RNA transport_Homo sapiens_hsa030130.54622355
112ErbB signaling pathway_Homo sapiens_hsa040120.54377390
113* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53568464
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50844543
115Legionellosis_Homo sapiens_hsa051340.47198020
116Choline metabolism in cancer_Homo sapiens_hsa052310.46439157
117Inositol phosphate metabolism_Homo sapiens_hsa005620.43584211
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43312442
119Alcoholism_Homo sapiens_hsa050340.42528791
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.41592194
121mTOR signaling pathway_Homo sapiens_hsa041500.38853081
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.38332351
123Regulation of autophagy_Homo sapiens_hsa041400.34526676
124FoxO signaling pathway_Homo sapiens_hsa040680.34430976
125Pertussis_Homo sapiens_hsa051330.33609592
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33136592
127Dorso-ventral axis formation_Homo sapiens_hsa043200.32760823
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32679714
129Renal cell carcinoma_Homo sapiens_hsa052110.32235169
130Endocytosis_Homo sapiens_hsa041440.29249564
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26051796
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25825583
133Other glycan degradation_Homo sapiens_hsa005110.25443511
134Notch signaling pathway_Homo sapiens_hsa043300.25028399
135Prostate cancer_Homo sapiens_hsa052150.21800577
136Ras signaling pathway_Homo sapiens_hsa040140.20301218

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