SEPT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.64957074
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08837998
3COPI coating of Golgi vesicle (GO:0048205)3.99751114
4Golgi transport vesicle coating (GO:0048200)3.99751114
5signal peptide processing (GO:0006465)3.77261617
6regulation of metalloenzyme activity (GO:0048552)3.65728004
7negative regulation of phagocytosis (GO:0050765)3.51123915
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.47051307
9heart contraction (GO:0060047)3.41408557
10heart process (GO:0003015)3.41408557
11negative regulation of chondrocyte differentiation (GO:0032331)3.30161454
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29335344
13retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24828421
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.23367197
15axon extension involved in axon guidance (GO:0048846)3.23367197
16cullin deneddylation (GO:0010388)3.20088917
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18252347
18poly(A)+ mRNA export from nucleus (GO:0016973)3.14795005
19establishment of integrated proviral latency (GO:0075713)3.13044330
20kinetochore organization (GO:0051383)3.09826822
21negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.08919265
22mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08872297
23mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08872297
24hippo signaling (GO:0035329)3.03879904
25cell proliferation involved in kidney development (GO:0072111)3.03022317
26negative regulation of mast cell activation (GO:0033004)3.02708908
27protein deneddylation (GO:0000338)2.98518126
28cell adhesion mediated by integrin (GO:0033627)2.94294798
29collagen fibril organization (GO:0030199)2.92022973
30cell migration involved in sprouting angiogenesis (GO:0002042)2.91671719
31RNA-dependent DNA replication (GO:0006278)2.90120474
32cell differentiation involved in metanephros development (GO:0072202)2.88481867
33meiotic chromosome segregation (GO:0045132)2.88405250
34convergent extension (GO:0060026)2.85621951
35regulation of T cell chemotaxis (GO:0010819)2.79560061
36positive regulation of T cell chemotaxis (GO:0010820)2.79560061
37L-serine metabolic process (GO:0006563)2.79239288
38chondrocyte proliferation (GO:0035988)2.77504668
39definitive hemopoiesis (GO:0060216)2.77132429
40COPII vesicle coating (GO:0048208)2.76133269
41glomerulus development (GO:0032835)2.74558292
42DNA ligation (GO:0006266)2.74012237
43negative regulation of keratinocyte proliferation (GO:0010839)2.72778507
44CENP-A containing nucleosome assembly (GO:0034080)2.71459361
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71104418
46regulation of mitotic spindle checkpoint (GO:1903504)2.71104418
47neural crest cell development (GO:0014032)2.70313243
48regulation of mitotic spindle organization (GO:0060236)2.69622875
49establishment of chromosome localization (GO:0051303)2.68478310
50negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68223927
51skin morphogenesis (GO:0043589)2.68208236
52metanephric mesenchyme development (GO:0072075)2.67892240
53sequestering of actin monomers (GO:0042989)2.67127812
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66265198
55DNA unwinding involved in DNA replication (GO:0006268)2.64519859
56dendritic cell chemotaxis (GO:0002407)2.63750318
57negative regulation of myoblast differentiation (GO:0045662)2.63137889
58DNA double-strand break processing (GO:0000729)2.62214069
59regulation of DNA-templated transcription, initiation (GO:2000142)2.59612458
60nuclear pore complex assembly (GO:0051292)2.59242456
61negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.57790343
62regulation of interleukin-8 secretion (GO:2000482)2.56500602
63kinetochore assembly (GO:0051382)2.56295265
64negative regulation of striated muscle cell apoptotic process (GO:0010664)2.54163788
65Notch signaling involved in heart development (GO:0061314)2.53872550
66protein heterotrimerization (GO:0070208)2.52445295
67mitotic G2/M transition checkpoint (GO:0044818)2.52300208
68kidney mesenchyme development (GO:0072074)2.51628773
69hyperosmotic salinity response (GO:0042538)2.51614749
70IMP biosynthetic process (GO:0006188)2.51592945
71chromatin remodeling at centromere (GO:0031055)2.51510480
72Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51420842
73myoblast migration (GO:0051451)2.50316202
74regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48732226
75viral mRNA export from host cell nucleus (GO:0046784)2.48685892
76nuclear pore organization (GO:0006999)2.48644876
77endodermal cell differentiation (GO:0035987)2.48359879
78regulation of establishment of planar polarity (GO:0090175)2.48062257
79negative regulation of stem cell proliferation (GO:2000647)2.47980103
80embryonic foregut morphogenesis (GO:0048617)2.47778172
81regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.47706519
82mitotic G2 DNA damage checkpoint (GO:0007095)2.47354841
83cell surface receptor signaling pathway involved in heart development (GO:0061311)2.47048388
84notochord development (GO:0030903)2.46943637
85cell proliferation involved in metanephros development (GO:0072203)2.46324035
86neutrophil activation involved in immune response (GO:0002283)2.46270791
87lymph vessel development (GO:0001945)2.45292382
88positive regulation of male gonad development (GO:2000020)2.44020126
89telomere maintenance via recombination (GO:0000722)2.43541271
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43176150
91mitotic chromosome condensation (GO:0007076)2.42444816
92protein localization to kinetochore (GO:0034501)2.42177982
93pore complex assembly (GO:0046931)2.41613431
94regulation of transforming growth factor beta2 production (GO:0032909)2.40724163
95regulation of integrin-mediated signaling pathway (GO:2001044)2.39576803
96endothelial cell morphogenesis (GO:0001886)2.38734672
97vesicle coating (GO:0006901)2.38385529
98cellular response to prostaglandin stimulus (GO:0071379)2.37318627
99morphogenesis of an epithelial sheet (GO:0002011)2.35769649
100histamine secretion (GO:0001821)2.35751280
101basement membrane organization (GO:0071711)2.35712010
102negative regulation of signal transduction by p53 class mediator (GO:1901797)2.34506324
103positive regulation of chemokine secretion (GO:0090197)2.34312858
104mitotic recombination (GO:0006312)2.32624796
105negative regulation of cartilage development (GO:0061037)2.32575693
106positive regulation of actin filament depolymerization (GO:0030836)2.32480516
107transcription initiation from RNA polymerase I promoter (GO:0006361)2.31667053
108negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.31443986
109maturation of 5.8S rRNA (GO:0000460)2.30905015
110positive regulation of endothelial cell differentiation (GO:0045603)2.30862181
111embryonic skeletal joint morphogenesis (GO:0060272)2.30775095
112retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30311704
113cellular response to gamma radiation (GO:0071480)2.30166674
114negative regulation of fibroblast apoptotic process (GO:2000270)2.30098342
115apical protein localization (GO:0045176)2.30011932
116purine nucleobase biosynthetic process (GO:0009113)2.29998126
117regulation of smooth muscle cell differentiation (GO:0051150)2.29802228
118mesenchymal cell differentiation (GO:0048762)2.28296001
119nucleotide transmembrane transport (GO:1901679)2.27985622
120cyclooxygenase pathway (GO:0019371)2.27854189
121diterpenoid biosynthetic process (GO:0016102)2.27830259
122mitotic cytokinesis (GO:0000281)2.27652307
123regulation of myoblast differentiation (GO:0045661)2.27533978
124mitotic metaphase plate congression (GO:0007080)2.27454604
125regulation of male gonad development (GO:2000018)2.27137073
126dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26914400
127regulation of glomerulus development (GO:0090192)2.26524777
128regulation of double-strand break repair via homologous recombination (GO:0010569)2.26372183
129ectodermal placode formation (GO:0060788)2.26312008
130ganglion development (GO:0061548)2.26232349
131protein retention in ER lumen (GO:0006621)2.25662874
132mitotic sister chromatid cohesion (GO:0007064)2.25015928
133cochlea morphogenesis (GO:0090103)2.24873568
134alpha-linolenic acid metabolic process (GO:0036109)2.24720434
135muscle cell migration (GO:0014812)2.24097656
136positive regulation of protein import into nucleus, translocation (GO:0033160)2.23946145
137protein localization to cell surface (GO:0034394)2.22994195
138positive regulation of T cell migration (GO:2000406)2.22960191
139dendritic cell migration (GO:0036336)2.22296891
140response to X-ray (GO:0010165)2.22191146
141barbed-end actin filament capping (GO:0051016)2.21779431
142metaphase plate congression (GO:0051310)2.21714588
143positive regulation of smooth muscle cell migration (GO:0014911)2.21364629
144mesenchymal cell development (GO:0014031)2.21167042
145sister chromatid segregation (GO:0000819)2.20474550
146regulation of cardioblast differentiation (GO:0051890)2.20214779
147myelin assembly (GO:0032288)2.20148675
148regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.20125105
149mesenchymal cell proliferation (GO:0010463)2.19098681
150non-canonical Wnt signaling pathway (GO:0035567)2.18937718
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.18855892
152protein localization to chromosome, centromeric region (GO:0071459)2.18655646
153lateral sprouting from an epithelium (GO:0060601)2.18333440
154establishment of viral latency (GO:0019043)2.18086954
155cytoskeleton-dependent cytokinesis (GO:0061640)2.17857249
156DNA replication checkpoint (GO:0000076)2.17471020
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.17407136
158establishment or maintenance of bipolar cell polarity (GO:0061245)2.17407136
159substrate adhesion-dependent cell spreading (GO:0034446)2.17353295
160cellular protein complex localization (GO:0034629)2.17348615
161transcription from RNA polymerase I promoter (GO:0006360)2.17134386
162establishment of planar polarity (GO:0001736)2.17008832
163establishment of tissue polarity (GO:0007164)2.17008832
164peptidyl-proline hydroxylation (GO:0019511)2.16803875
165craniofacial suture morphogenesis (GO:0097094)2.16798640
166positive regulation of keratinocyte differentiation (GO:0045618)2.16453138
167regulation of sister chromatid cohesion (GO:0007063)2.15998663
168mesenchymal-epithelial cell signaling (GO:0060638)2.15510440
169smooth muscle tissue development (GO:0048745)2.14917527
170cellular response to ionizing radiation (GO:0071479)2.14509071
171regulation of cell proliferation involved in kidney development (GO:1901722)2.14135625
172regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.14107657
173asymmetric protein localization (GO:0008105)2.13853388
174regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.13775843
175dermatan sulfate biosynthetic process (GO:0030208)2.12988453
176collagen metabolic process (GO:0032963)2.12744648
177radial glial cell differentiation (GO:0060019)2.12527879
178regulation of spindle organization (GO:0090224)2.12419405
179lens morphogenesis in camera-type eye (GO:0002089)2.11816797
180ventricular cardiac muscle cell development (GO:0055015)2.11530401
181negative chemotaxis (GO:0050919)2.10174218
182vascular endothelial growth factor signaling pathway (GO:0038084)2.09125178
183extracellular fibril organization (GO:0043206)2.09037624
184axis elongation (GO:0003401)2.08278732
185chondrocyte development (GO:0002063)2.06928347
186gap junction assembly (GO:0016264)2.06351429
187camera-type eye morphogenesis (GO:0048593)2.05439197
188lung-associated mesenchyme development (GO:0060484)2.05292018
189mitotic sister chromatid segregation (GO:0000070)2.05207936
190regulation of non-canonical Wnt signaling pathway (GO:2000050)2.04939424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64572684
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.78594054
3CLOCK_20551151_ChIP-Seq_293T_Human3.32648075
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15183656
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06400830
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.06146012
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97291654
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.83289778
9ELK1_19687146_ChIP-ChIP_HELA_Human2.72544383
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.63372396
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49969655
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40085755
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39782814
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22373420
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.21616834
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.16768442
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14228198
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10368649
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.08925530
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.01181902
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.00509319
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00472100
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99136527
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96782100
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.92073474
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91250899
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.89391054
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89200532
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.88446653
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85334178
31EWS_26573619_Chip-Seq_HEK293_Human1.78485230
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78460185
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78214251
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77130146
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.77106869
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74424525
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.73219614
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73109415
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71939904
40AR_21909140_ChIP-Seq_LNCAP_Human1.69377146
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68545010
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64193259
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64176928
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62493465
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.61160818
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60572610
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59670169
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.59001776
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57712611
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54867200
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54067551
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53848617
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53762368
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53165554
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52298687
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.50757703
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.50538601
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49809136
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49610664
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47674750
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47365963
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.45295182
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44501888
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.42896646
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40939013
66CJUN_26792858_Chip-Seq_BT549_Human1.40668757
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38425139
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36818323
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36722502
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36069635
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34918691
72BRD4_25478319_ChIP-Seq_HGPS_Human1.34152545
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33511758
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31072738
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.31007536
76TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30850244
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30240070
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30240070
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29927832
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29887967
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29584485
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28293251
83GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26368719
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25579716
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24902379
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23399124
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23399124
88FUS_26573619_Chip-Seq_HEK293_Human1.23114866
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23001566
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22732454
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20821150
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20111902
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19265401
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17942166
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.16655615
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16180645
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.15981824
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15536964
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14346078
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14127206
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13094608
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.11810264
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.10619046
104VDR_23849224_ChIP-Seq_CD4+_Human1.10405859
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10329033
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09994185
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09899906
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.09144585
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08802005
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07165394
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06504396
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05898487
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.05581290
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05281188
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04988940
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04262437
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04018910
118SOX9_26525672_Chip-Seq_HEART_Mouse1.03601421
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03568999
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.02947416
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.01937124
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01441381
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00756802
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00694894
125SOX2_20726797_ChIP-Seq_SW620_Human0.99966454
126MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99931314
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99837657
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99507531
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99142362
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99138797
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99138797
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99138797
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99029250
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99003217
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97699038
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97662168
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96934678
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96934480
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.96581049
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95968706
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95929005
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.95007687
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94984081
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94281412
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94027007
146DCP1A_22483619_ChIP-Seq_HELA_Human0.93530052
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92414456
148NANOG_16518401_ChIP-PET_MESCs_Mouse0.92316601
149NMYC_18555785_Chip-Seq_ESCs_Mouse0.91393574
150MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91258501
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90696638
152P53_22387025_ChIP-Seq_ESCs_Mouse0.90662146
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89980079
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89925099
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89723180
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89693353
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89611857
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89394894
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.89336063
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.88862998
161TP53_18474530_ChIP-ChIP_U2OS_Human0.86830950
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86068824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.38183787
2MP0005503_abnormal_tendon_morphology3.17413005
3MP0003950_abnormal_plasma_membrane2.90423886
4MP0009697_abnormal_copulation2.70243287
5MP0003941_abnormal_skin_development2.47018338
6MP0008007_abnormal_cellular_replicative2.43694443
7MP0008057_abnormal_DNA_replication2.42423389
8MP0005257_abnormal_intraocular_pressure2.41846188
9MP0001879_abnormal_lymphatic_vessel2.28352836
10MP0000566_synostosis2.27426124
11MP0000516_abnormal_urinary_system2.22460198
12MP0005367_renal/urinary_system_phenotyp2.22460198
13MP0003279_aneurysm2.22214895
14MP0005171_absent_coat_pigmentation2.09573307
15MP0006054_spinal_hemorrhage2.09172800
16MP0005623_abnormal_meninges_morphology2.09108447
17MP0004272_abnormal_basement_membrane2.05543048
18MP0003123_paternal_imprinting2.04671427
19MP0010352_gastrointestinal_tract_polyps2.00821870
20MP0002009_preneoplasia1.93378134
21MP0004782_abnormal_surfactant_physiolog1.91141683
22MP0003121_genomic_imprinting1.86159266
23MP0001299_abnormal_eye_distance/1.81945985
24MP0003943_abnormal_hepatobiliary_system1.73781697
25MP0005275_abnormal_skin_tensile1.72563186
26MP0010368_abnormal_lymphatic_system1.72419209
27MP0010094_abnormal_chromosome_stability1.68627088
28MP0002697_abnormal_eye_size1.67673127
29MP0008058_abnormal_DNA_repair1.63670654
30MP0010030_abnormal_orbit_morphology1.63396854
31MP0001849_ear_inflammation1.62526074
32MP0009053_abnormal_anal_canal1.61613386
33MP0002163_abnormal_gland_morphology1.58317093
34MP0000534_abnormal_ureter_morphology1.54910232
35MP0000767_abnormal_smooth_muscle1.54036644
36MP0002938_white_spotting1.53625337
37MP0001293_anophthalmia1.52146869
38MP0002877_abnormal_melanocyte_morpholog1.52083098
39MP0002233_abnormal_nose_morphology1.50728562
40MP0003122_maternal_imprinting1.50318447
41MP0001542_abnormal_bone_strength1.50227962
42MP0000428_abnormal_craniofacial_morphol1.48559969
43MP0003786_premature_aging1.47290219
44MP0005408_hypopigmentation1.45306384
45MP0003385_abnormal_body_wall1.44332977
46MP0003828_pulmonary_edema1.42051465
47MP0000762_abnormal_tongue_morphology1.41490147
48MP0002084_abnormal_developmental_patter1.41311260
49MP0009780_abnormal_chondrocyte_physiolo1.40993287
50MP0003942_abnormal_urinary_system1.39352439
51MP0003077_abnormal_cell_cycle1.38793127
52MP0005508_abnormal_skeleton_morphology1.36348744
53MP0001177_atelectasis1.35530923
54MP0002092_abnormal_eye_morphology1.35469342
55MP0003567_abnormal_fetal_cardiomyocyte1.35451659
56MP0009250_abnormal_appendicular_skeleto1.34540153
57MP0003091_abnormal_cell_migration1.33091281
58MP0002282_abnormal_trachea_morphology1.32463549
59MP0002148_abnormal_hypersensitivity_rea1.31692787
60MP0003693_abnormal_embryo_hatching1.29321897
61MP0001835_abnormal_antigen_presentation1.27703232
62MP0001730_embryonic_growth_arrest1.26636709
63MP0004858_abnormal_nervous_system1.26194298
64MP0002085_abnormal_embryonic_tissue1.24368514
65MP0002396_abnormal_hematopoietic_system1.23223871
66MP0002896_abnormal_bone_mineralization1.19850177
67MP0003890_abnormal_embryonic-extraembry1.18453859
68MP0000432_abnormal_head_morphology1.18218120
69MP0003935_abnormal_craniofacial_develop1.17503428
70MP0000372_irregular_coat_pigmentation1.17006920
71MP0002132_abnormal_respiratory_system1.15694516
72MP0001672_abnormal_embryogenesis/_devel1.14709538
73MP0005380_embryogenesis_phenotype1.14709538
74MP0000778_abnormal_nervous_system1.12922703
75MP0009672_abnormal_birth_weight1.12917900
76MP0003186_abnormal_redox_activity1.12705808
77MP0004134_abnormal_chest_morphology1.12297472
78MP0000015_abnormal_ear_pigmentation1.10716941
79MP0001119_abnormal_female_reproductive1.07918246
80MP0008932_abnormal_embryonic_tissue1.06895203
81MP0002088_abnormal_embryonic_growth/wei1.05265578
82MP0003315_abnormal_perineum_morphology1.02313934
83MP0005409_darkened_coat_color1.01242792
84MP0003115_abnormal_respiratory_system1.00222013
85MP0005388_respiratory_system_phenotype1.00200259
86MP0002133_abnormal_respiratory_system1.00200259
87MP0009703_decreased_birth_body0.99340242
88MP0009384_cardiac_valve_regurgitation0.98611010
89MP0003111_abnormal_nucleus_morphology0.98418079
90MP0002111_abnormal_tail_morphology0.98370819
91MP0004197_abnormal_fetal_growth/weight/0.97840253
92MP0001958_emphysema0.97527837
93MP0003136_yellow_coat_color0.97488905
94MP0001188_hyperpigmentation0.96012329
95MP0001175_abnormal_lung_morphology0.95875302
96MP0001697_abnormal_embryo_size0.95143191
97MP0003566_abnormal_cell_adhesion0.95077137
98MP0002160_abnormal_reproductive_system0.94521127
99MP0003119_abnormal_digestive_system0.94377216
100MP0000678_abnormal_parathyroid_gland0.94281028
101MP0002116_abnormal_craniofacial_bone0.94139288
102MP0009785_altered_susceptibility_to0.92990963
103MP0002086_abnormal_extraembryonic_tissu0.92870909
104MP0000049_abnormal_middle_ear0.92547593
105MP0005084_abnormal_gallbladder_morpholo0.92463094
106MP0002060_abnormal_skin_morphology0.92128815
107MP0003861_abnormal_nervous_system0.91814651
108MP0003937_abnormal_limbs/digits/tail_de0.91686628
109MP0005390_skeleton_phenotype0.90410304
110MP0000350_abnormal_cell_proliferation0.89214421
111MP0002109_abnormal_limb_morphology0.87801995
112MP0002080_prenatal_lethality0.87466430
113MP0003755_abnormal_palate_morphology0.87205923
114MP0005023_abnormal_wound_healing0.86775507
115MP0008789_abnormal_olfactory_epithelium0.86359615
116MP0003787_abnormal_imprinting0.86127510
117MP0005197_abnormal_uvea_morphology0.85737343
118MP0003705_abnormal_hypodermis_morpholog0.84872806
119MP0002295_abnormal_pulmonary_circulatio0.84771528
120MP0001614_abnormal_blood_vessel0.82899893
121MP0002108_abnormal_muscle_morphology0.82469943
122MP0000733_abnormal_muscle_development0.81757692
123MP0002115_abnormal_skeleton_extremities0.81676410
124MP0002128_abnormal_blood_circulation0.81182620
125MP0000681_abnormal_thyroid_gland0.81062920
126MP0005499_abnormal_olfactory_system0.81060975
127MP0005394_taste/olfaction_phenotype0.81060975
128MP0000343_altered_response_to0.81031207
129MP0000163_abnormal_cartilage_morphology0.81030230
130MP0002006_tumorigenesis0.79972747
131MP0000751_myopathy0.79884862
132MP0002932_abnormal_joint_morphology0.79795621
133MP0005076_abnormal_cell_differentiation0.79452950
134MP0010234_abnormal_vibrissa_follicle0.78662826
135MP0004084_abnormal_cardiac_muscle0.77741745
136MP0002114_abnormal_axial_skeleton0.77516641
137MP0000537_abnormal_urethra_morphology0.77111334
138MP0005193_abnormal_anterior_eye0.76835111
139MP0001915_intracranial_hemorrhage0.76224457
140MP0005248_abnormal_Harderian_gland0.76013522
141MP0000749_muscle_degeneration0.75133641
142MP0002933_joint_inflammation0.74275717
143MP0004883_abnormal_blood_vessel0.73173680
144MP0001243_abnormal_dermal_layer0.72593776
145MP0006138_congestive_heart_failure0.72009058
146MP0002249_abnormal_larynx_morphology0.71859369
147MP0001286_abnormal_eye_development0.71169802
148MP0005389_reproductive_system_phenotype0.70461505
149MP0006292_abnormal_olfactory_placode0.70352868
150MP0004957_abnormal_blastocyst_morpholog0.70345666
151MP0004808_abnormal_hematopoietic_stem0.69841596
152MP0003984_embryonic_growth_retardation0.69026621
153MP0002925_abnormal_cardiovascular_devel0.68807156

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.64754104
2Spinal cord lesions (HP:0100561)4.20350667
3Syringomyelia (HP:0003396)4.20350667
4Asymmetry of the thorax (HP:0001555)3.68013703
5Arterial tortuosity (HP:0005116)3.54417837
6Abnormality of incisor morphology (HP:0011063)3.46571675
7Aortic dissection (HP:0002647)3.30431862
8Neonatal short-limb short stature (HP:0008921)3.24057879
9Shallow orbits (HP:0000586)2.98334693
10Adrenal hypoplasia (HP:0000835)2.90913049
11Embryonal renal neoplasm (HP:0011794)2.88669688
12Bladder diverticulum (HP:0000015)2.80016127
13Cortical dysplasia (HP:0002539)2.79631943
14Nephroblastoma (Wilms tumor) (HP:0002667)2.76127496
15Ankle contracture (HP:0006466)2.74862797
16Abnormal lung lobation (HP:0002101)2.71487373
17Deep philtrum (HP:0002002)2.67551942
18Coronal craniosynostosis (HP:0004440)2.62186547
19Hepatoblastoma (HP:0002884)2.59833884
20Aortic aneurysm (HP:0004942)2.57959185
2111 pairs of ribs (HP:0000878)2.57528661
22Mesomelia (HP:0003027)2.56135075
23Diastasis recti (HP:0001540)2.53624255
24Pulmonary artery stenosis (HP:0004415)2.52224877
25Chromsome breakage (HP:0040012)2.52199877
26Vertebral arch anomaly (HP:0008438)2.48648972
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45000234
28Metaphyseal dysplasia (HP:0100255)2.44895745
29Short middle phalanx of the 5th finger (HP:0004220)2.44723416
30Atrophic scars (HP:0001075)2.42458781
31Type I transferrin isoform profile (HP:0003642)2.38891019
32Degeneration of anterior horn cells (HP:0002398)2.37868895
33Abnormality of the anterior horn cell (HP:0006802)2.37868895
34Long clavicles (HP:0000890)2.36742579
35True hermaphroditism (HP:0010459)2.36684067
36Spastic diplegia (HP:0001264)2.31541470
37Ectopic kidney (HP:0000086)2.26264725
38Optic nerve coloboma (HP:0000588)2.25961223
39Bowel diverticulosis (HP:0005222)2.24591143
40Cutaneous melanoma (HP:0012056)2.23478553
41Abnormality of the nasal septum (HP:0000419)2.20495205
42Spinal rigidity (HP:0003306)2.19955492
43Wide anterior fontanel (HP:0000260)2.17890841
44Renal duplication (HP:0000075)2.16992869
45Increased nuchal translucency (HP:0010880)2.16745067
46Birth length less than 3rd percentile (HP:0003561)2.15953186
47Mitral valve prolapse (HP:0001634)2.15547444
48Bilateral sensorineural hearing impairment (HP:0008619)2.13968374
49Arnold-Chiari malformation (HP:0002308)2.13474268
50Neoplasm of the adrenal cortex (HP:0100641)2.11487329
51Trigonocephaly (HP:0000243)2.10428394
52Abnormal pancreas size (HP:0012094)2.10413509
53Broad metatarsal (HP:0001783)2.08098175
54Back pain (HP:0003418)2.07859029
55Hypoplastic left heart (HP:0004383)2.07769706
56White forelock (HP:0002211)2.06939336
57Ulnar bowing (HP:0003031)2.04160799
58Patchy hypopigmentation of hair (HP:0011365)2.03971791
59Irregular epiphyses (HP:0010582)2.02794360
60Nonimmune hydrops fetalis (HP:0001790)2.01463033
61Patent foramen ovale (HP:0001655)2.01161300
62Rhizomelia (HP:0008905)2.00925552
63Enlarged kidneys (HP:0000105)2.00300257
64Abnormality of the incisor (HP:0000676)1.99477283
65Flat capital femoral epiphysis (HP:0003370)1.99261298
66Abnormality of dentin (HP:0010299)1.98003693
67Aplasia involving bones of the extremities (HP:0009825)1.97683459
68Aplasia involving bones of the upper limbs (HP:0009823)1.97683459
69Aplasia of the phalanges of the hand (HP:0009802)1.97683459
70Vitreoretinal degeneration (HP:0000655)1.97494136
71Alveolar cell carcinoma (HP:0006519)1.97254895
72Meckel diverticulum (HP:0002245)1.96489490
73Heterochromia iridis (HP:0001100)1.96351585
74Abnormal umbilical cord blood vessels (HP:0011403)1.95912353
75Single umbilical artery (HP:0001195)1.95912353
76Abnormality of the fetal cardiovascular system (HP:0010948)1.95912353
77Microglossia (HP:0000171)1.95419092
78Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.95364372
79Pterygium (HP:0001059)1.94874983
80Pulmonic stenosis (HP:0001642)1.94629838
81Papillary thyroid carcinoma (HP:0002895)1.93571071
82Epiphyseal dysplasia (HP:0002656)1.92224592
83Broad palm (HP:0001169)1.91882104
84Hyperextensible skin (HP:0000974)1.90287948
85Breech presentation (HP:0001623)1.89923555
86Mild short stature (HP:0003502)1.89221977
87Thyroid carcinoma (HP:0002890)1.88556341
88Cerebral aneurysm (HP:0004944)1.88106913
89Omphalocele (HP:0001539)1.87504774
90Absent eyebrow (HP:0002223)1.86972637
91Mitral regurgitation (HP:0001653)1.86791455
92Camptodactyly of toe (HP:0001836)1.84600827
93Short 4th metacarpal (HP:0010044)1.83836658
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83836658
95Abnormality of the phalanges of the 5th finger (HP:0004213)1.83510175
96Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83269355
97Vertebral hypoplasia (HP:0008417)1.82899103
98Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82899103
99Aortic valve stenosis (HP:0001650)1.82687204
100Broad long bones (HP:0005622)1.82408868
101Hyperacusis (HP:0010780)1.81904963
102Hypoplastic heart (HP:0001961)1.81249140
103Abnormality of the metopic suture (HP:0005556)1.81074795
104Submucous cleft hard palate (HP:0000176)1.79717959
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.79669119
106Xerostomia (HP:0000217)1.79489432
107Small epiphyses (HP:0010585)1.78091092
108Myelomeningocele (HP:0002475)1.77958869
109Short nail (HP:0001799)1.77849969
110Abnormality of the ileum (HP:0001549)1.77728839
111Renal cortical cysts (HP:0000803)1.77613811
112Biconcave vertebral bodies (HP:0004586)1.77284183
113Abnormality of the nasolacrimal system (HP:0000614)1.76891520
114Vertebral clefting (HP:0008428)1.75331748
115Distal lower limb muscle weakness (HP:0009053)1.74740606
116Abnormality of the acetabulum (HP:0003170)1.74596457
117Prominent metopic ridge (HP:0005487)1.74543350
118Turricephaly (HP:0000262)1.74292962
119Cutaneous finger syndactyly (HP:0010554)1.73682238
120Abnormal foot bone ossification (HP:0010675)1.73669250
121Insidious onset (HP:0003587)1.73588125
122Termporal pattern (HP:0011008)1.73588125
123Natal tooth (HP:0000695)1.73231095
124Protruding ear (HP:0000411)1.73131636
125Hammertoe (HP:0001765)1.73112627
126Joint laxity (HP:0001388)1.72823430
127Pancreatic islet-cell hyperplasia (HP:0004510)1.71599700
128Abnormality of the calcaneus (HP:0008364)1.70124022
129Preauricular pit (HP:0004467)1.69245935
130Periauricular skin pits (HP:0100277)1.69245935
131Thin ribs (HP:0000883)1.69165679
132Follicular hyperkeratosis (HP:0007502)1.69151721
133Overriding aorta (HP:0002623)1.69025178
134Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.68386405
135Abnormality of the lacrimal duct (HP:0011481)1.68132094
136Insomnia (HP:0100785)1.67906724
137Abnormal delivery (HP:0001787)1.67310700
138Broad thumb (HP:0011304)1.67293685
139Fragile skin (HP:0001030)1.66337940
140Keratoconjunctivitis sicca (HP:0001097)1.64955165
141Blue sclerae (HP:0000592)1.64362809
142Absent frontal sinuses (HP:0002688)1.63372644
143Neonatal hypoglycemia (HP:0001998)1.63255533
144Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63219833
145Genu recurvatum (HP:0002816)1.63197081
146Dilatation of the ascending aorta (HP:0005111)1.63011525
147Fibular hypoplasia (HP:0003038)1.62829580
148Soft skin (HP:0000977)1.62270092
149Hypoplasia of the iris (HP:0007676)1.62174801
150Stillbirth (HP:0003826)1.61205326
151Cervical subluxation (HP:0003308)1.60979918
152Abnormality of the frontal sinuses (HP:0002687)1.60689331
153Premature rupture of membranes (HP:0001788)1.60456018
154Broad phalanx (HP:0006009)1.59994283
155Cutaneous syndactyly (HP:0012725)1.59954041
156Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.59770803
157Postaxial foot polydactyly (HP:0001830)1.59428510
158Gastrointestinal carcinoma (HP:0002672)1.59407688
159Malignant gastrointestinal tract tumors (HP:0006749)1.59407688
160Vascular tortuosity (HP:0004948)1.59335190
161Absent eyelashes (HP:0000561)1.59111330
162Deviation of the hallux (HP:0010051)1.59067550
163Renovascular hypertension (HP:0100817)1.58994688
164Preaxial hand polydactyly (HP:0001177)1.58924130
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58847074
166Pancreatic fibrosis (HP:0100732)1.57384794
167Missing ribs (HP:0000921)1.57364236
168Optic neuritis (HP:0100653)1.57336401
169Retrobulbar optic neuritis (HP:0100654)1.57336401
170Neoplasm of the adrenal gland (HP:0100631)1.56670318
171Cystic hygroma (HP:0000476)1.56237570
172Wormian bones (HP:0002645)1.56224164
173Meningioma (HP:0002858)1.55978080
174Vertebral compression fractures (HP:0002953)1.55822413
175Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55317086
176Overgrowth (HP:0001548)1.55311744
177Absent epiphyses (HP:0010577)1.54198535
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54198535
179Inguinal hernia (HP:0000023)1.54036323
180Uterine leiomyosarcoma (HP:0002891)1.52368282
181Leiomyosarcoma (HP:0100243)1.52368282
182High anterior hairline (HP:0009890)1.52189953
183Decreased skull ossification (HP:0004331)1.50836905
184Abnormality of the diencephalon (HP:0010662)1.50773533
185Elfin facies (HP:0004428)1.50756377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.87583217
2ERBB33.79752814
3PDGFRA3.27665958
4MAP3K142.94435566
5NUAK12.78715813
6FRK2.74180644
7STK38L2.48839559
8BMPR22.43182550
9NTRK12.37400686
10TRPM72.33133435
11MKNK12.32407219
12EIF2AK12.28436724
13AKT32.26242644
14STK242.20696539
15PRPF4B2.14767066
16LATS22.06468703
17NEK91.99303665
18MET1.99179655
19MKNK21.96030745
20NEK11.93688355
21BCR1.86672261
22SRPK11.78561715
23NEK61.75182632
24IRAK41.70231986
25PLK41.69773439
26PLK31.64909735
27FGFR41.63974191
28BRSK21.62241897
29PAK41.58064177
30CLK11.53512755
31PBK1.52301409
32EIF2AK21.51491262
33PTK21.51051223
34PLK21.48625385
35EIF2AK31.46349802
36TNIK1.44685137
37SIK31.44403877
38CDK61.43688534
39BMPR1B1.41323595
40MST41.39426754
41MAP3K101.39311831
42DDR21.38624427
43STK31.37227435
44ERBB41.36615213
45PAK21.35234658
46TIE11.34336571
47IRAK31.33862680
48FGFR11.33143528
49MYLK1.30871439
50YES11.30842177
51TESK11.29414127
52OBSCN1.26617055
53CDK81.23456043
54SGK21.21125871
55BRD41.20490567
56LIMK11.20273721
57TXK1.17539848
58LATS11.17318382
59PIK3CA1.17049252
60CHUK1.16235672
61ROCK21.13011292
62PKN21.11119998
63CDK121.10367270
64RIPK11.08779090
65ACVR1B1.06624631
66TYRO31.05573522
67MAP3K31.05275871
68VRK11.03585622
69PASK1.02950008
70MOS1.02020572
71EEF2K1.01847253
72NEK21.00858815
73PNCK1.00125485
74TGFBR10.98876800
75EPHB10.97295321
76PDGFRB0.95424455
77SCYL20.93557585
78TEC0.92192009
79PIM20.91258589
80NTRK20.85772299
81CDC70.85658086
82IKBKB0.83412038
83ICK0.82260826
84JAK30.81540584
85STK40.81377221
86FER0.79795463
87CDK180.78163984
88TAOK20.77644550
89CDK140.77195799
90ATR0.75654441
91PRKD30.74544700
92CDK150.72894000
93TRIM280.72533257
94DMPK0.72332457
95EPHB20.67783957
96FLT30.67709300
97KSR10.67603717
98SGK30.66021114
99CDK11A0.65956448
100ALK0.65167672
101CSNK1A1L0.65011525
102CSNK1G10.64860876
103BRSK10.64766357
104PLK10.63512665
105CAMK1G0.62719203
106PIM10.60575261
107PAK60.58777952
108BUB10.58691513
109EPHA30.58590188
110RPS6KB10.58369021
111AKT20.58199559
112TTN0.56871910
113MTOR0.56110710
114ATM0.55982378
115SGK4940.53756948
116SGK2230.53756948
117AURKB0.52961069
118DYRK1B0.52407352
119CDK90.51729620
120RPS6KA60.51706653
121TRIB30.51458220
122CDK70.51436789
123RET0.51381017
124RPS6KC10.50673239
125RPS6KL10.50673239
126RPS6KA40.50632839
127TAF10.48923145
128CSNK1G20.48679410
129SMG10.48522612
130BMX0.48349263
131IKBKE0.46157954
132MAP2K30.46081839
133CSNK1G30.44613348
134CHEK20.43783841
135NLK0.42834965
136WEE10.42262849
137TSSK60.41868765
138* CSNK2A10.41498720
139PDK20.40721897
140MAPKAPK20.39096958
141MAPK130.38845844
142FGFR30.35880407
143ADRBK20.35807426
144MARK30.35236952
145PIK3CG0.33871798
146PRKCD0.31508310
147PRKG20.29711909
148ROCK10.29069492
149PRKCE0.28964142
150PKN10.28578028
151MELK0.28553606
152FGFR20.27556870
153TTK0.26953264
154CHEK10.26644785
155BRAF0.24677475
156STK100.24088913
157MAPK30.22193716

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.17991828
2DNA replication_Homo sapiens_hsa030302.52395641
3Base excision repair_Homo sapiens_hsa034102.43953548
4Mismatch repair_Homo sapiens_hsa034302.32609885
5Homologous recombination_Homo sapiens_hsa034402.28693286
6Proteasome_Homo sapiens_hsa030502.26803817
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22873847
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08817264
9Non-homologous end-joining_Homo sapiens_hsa034502.08582633
10Cell cycle_Homo sapiens_hsa041102.08087229
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00973566
12Basal transcription factors_Homo sapiens_hsa030221.99940388
13Nucleotide excision repair_Homo sapiens_hsa034201.92334669
14RNA degradation_Homo sapiens_hsa030181.86061579
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85413232
16RNA polymerase_Homo sapiens_hsa030201.78430374
17Fanconi anemia pathway_Homo sapiens_hsa034601.76698432
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68733848
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68252434
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63439323
21Arachidonic acid metabolism_Homo sapiens_hsa005901.62308104
22Allograft rejection_Homo sapiens_hsa053301.61342769
23One carbon pool by folate_Homo sapiens_hsa006701.57693047
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57603909
25Biosynthesis of amino acids_Homo sapiens_hsa012301.56978671
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53527698
27Graft-versus-host disease_Homo sapiens_hsa053321.50759331
28Hedgehog signaling pathway_Homo sapiens_hsa043401.47953076
29Propanoate metabolism_Homo sapiens_hsa006401.45193269
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43553307
31TGF-beta signaling pathway_Homo sapiens_hsa043501.43541389
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42527442
33RNA transport_Homo sapiens_hsa030131.41262192
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40776295
35Legionellosis_Homo sapiens_hsa051341.35694218
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.34780692
37Autoimmune thyroid disease_Homo sapiens_hsa053201.33439082
38Fatty acid elongation_Homo sapiens_hsa000621.31455384
39Adherens junction_Homo sapiens_hsa045201.31190627
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30761398
41Pyrimidine metabolism_Homo sapiens_hsa002401.27751726
42Vitamin B6 metabolism_Homo sapiens_hsa007501.27417658
43Malaria_Homo sapiens_hsa051441.26843502
44Fatty acid metabolism_Homo sapiens_hsa012121.26024783
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.25110919
46Protein digestion and absorption_Homo sapiens_hsa049741.24512995
47Carbon metabolism_Homo sapiens_hsa012001.23881704
48Herpes simplex infection_Homo sapiens_hsa051681.23496895
49Axon guidance_Homo sapiens_hsa043601.22264966
50Spliceosome_Homo sapiens_hsa030401.21023745
51Viral myocarditis_Homo sapiens_hsa054161.20967868
52p53 signaling pathway_Homo sapiens_hsa041151.20737088
53Measles_Homo sapiens_hsa051621.20401520
54Thyroid cancer_Homo sapiens_hsa052161.18375921
55Pyruvate metabolism_Homo sapiens_hsa006201.18296020
56Wnt signaling pathway_Homo sapiens_hsa043101.18017042
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16362867
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15920676
59ECM-receptor interaction_Homo sapiens_hsa045121.13985636
60Lysine degradation_Homo sapiens_hsa003101.13538039
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08648054
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08126348
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07302899
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.05603638
65Influenza A_Homo sapiens_hsa051641.04204371
66Leishmaniasis_Homo sapiens_hsa051401.03452484
67Endometrial cancer_Homo sapiens_hsa052131.03288542
68mRNA surveillance pathway_Homo sapiens_hsa030150.99943190
69Colorectal cancer_Homo sapiens_hsa052100.98595837
70Purine metabolism_Homo sapiens_hsa002300.95777108
71Gap junction_Homo sapiens_hsa045400.95700929
72Hippo signaling pathway_Homo sapiens_hsa043900.94030666
73MicroRNAs in cancer_Homo sapiens_hsa052060.93804672
74Focal adhesion_Homo sapiens_hsa045100.93150675
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91892502
76Melanogenesis_Homo sapiens_hsa049160.91088589
77Chronic myeloid leukemia_Homo sapiens_hsa052200.90578769
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90499796
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90119568
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89986034
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88828282
82Notch signaling pathway_Homo sapiens_hsa043300.87871636
83Prostate cancer_Homo sapiens_hsa052150.86890986
84Epstein-Barr virus infection_Homo sapiens_hsa051690.85533180
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85522091
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85267030
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83610904
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82949468
89Antigen processing and presentation_Homo sapiens_hsa046120.82747430
90* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82709180
91Bladder cancer_Homo sapiens_hsa052190.82255873
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80960313
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79496783
94Small cell lung cancer_Homo sapiens_hsa052220.79291087
95HTLV-I infection_Homo sapiens_hsa051660.79280290
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78335567
97Glutathione metabolism_Homo sapiens_hsa004800.77797324
98Arginine and proline metabolism_Homo sapiens_hsa003300.74682622
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.74558151
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74501223
101Phagosome_Homo sapiens_hsa041450.74403757
102Shigellosis_Homo sapiens_hsa051310.74210567
103Thyroid hormone synthesis_Homo sapiens_hsa049180.73858903
104Apoptosis_Homo sapiens_hsa042100.73483913
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73122787
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73025057
107Prion diseases_Homo sapiens_hsa050200.71561569
108Amoebiasis_Homo sapiens_hsa051460.70968238
109Pertussis_Homo sapiens_hsa051330.70864115
110Asthma_Homo sapiens_hsa053100.69148531
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68328851
112Pancreatic cancer_Homo sapiens_hsa052120.68234763
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67649502
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.67509641
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.65856801
116Hematopoietic cell lineage_Homo sapiens_hsa046400.65631802
117Glioma_Homo sapiens_hsa052140.65552653
118Pentose phosphate pathway_Homo sapiens_hsa000300.65147041
119Renal cell carcinoma_Homo sapiens_hsa052110.64942235
120Oocyte meiosis_Homo sapiens_hsa041140.64811161
121Toxoplasmosis_Homo sapiens_hsa051450.64168816
122TNF signaling pathway_Homo sapiens_hsa046680.64130181
123Type I diabetes mellitus_Homo sapiens_hsa049400.63880815
124Hepatitis B_Homo sapiens_hsa051610.62995537
125Basal cell carcinoma_Homo sapiens_hsa052170.62010346
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61631547
127N-Glycan biosynthesis_Homo sapiens_hsa005100.61361211
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61196784
129Proteoglycans in cancer_Homo sapiens_hsa052050.60215907
130Rap1 signaling pathway_Homo sapiens_hsa040150.59621056
131Fatty acid degradation_Homo sapiens_hsa000710.59560596
132Rheumatoid arthritis_Homo sapiens_hsa053230.58072308
133Galactose metabolism_Homo sapiens_hsa000520.57926652
134Melanoma_Homo sapiens_hsa052180.56137570
135Viral carcinogenesis_Homo sapiens_hsa052030.56040094
136Tight junction_Homo sapiens_hsa045300.54295559
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53448829
138Dilated cardiomyopathy_Homo sapiens_hsa054140.53098806
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52096108
140Salmonella infection_Homo sapiens_hsa051320.52092991
141Sphingolipid metabolism_Homo sapiens_hsa006000.51974894
142Pathways in cancer_Homo sapiens_hsa052000.51608077
143beta-Alanine metabolism_Homo sapiens_hsa004100.51578222
144AMPK signaling pathway_Homo sapiens_hsa041520.50521272
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.48523723
146PPAR signaling pathway_Homo sapiens_hsa033200.48069748
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47527898
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47361662
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47021911
150Sulfur metabolism_Homo sapiens_hsa009200.45682005
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44606967
152Choline metabolism in cancer_Homo sapiens_hsa052310.43889512
153Complement and coagulation cascades_Homo sapiens_hsa046100.42602262
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42110544
155Steroid biosynthesis_Homo sapiens_hsa001000.39471625
156Hepatitis C_Homo sapiens_hsa051600.37999536

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