SEPHS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.80241481
2positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.66436574
3auditory behavior (GO:0031223)4.64501374
4cellular potassium ion homeostasis (GO:0030007)4.63785017
5central nervous system projection neuron axonogenesis (GO:0021952)4.58645242
6neuron cell-cell adhesion (GO:0007158)4.46447398
7maturation of SSU-rRNA (GO:0030490)4.38577405
8regulation of neuron projection regeneration (GO:0070570)4.21746815
9regulation of axon regeneration (GO:0048679)4.21746815
10negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.20692287
11pyrimidine nucleobase catabolic process (GO:0006208)4.16869009
12regulation of cilium movement (GO:0003352)4.12016443
13mechanosensory behavior (GO:0007638)4.08682068
14neurotransmitter-gated ion channel clustering (GO:0072578)4.06319350
15sodium ion export (GO:0071436)4.03560272
16postsynaptic membrane organization (GO:0001941)4.00225961
17neuron fate determination (GO:0048664)3.86112714
18protein polyglutamylation (GO:0018095)3.80615771
19dendritic spine morphogenesis (GO:0060997)3.75718257
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65361243
21positive regulation of potassium ion transmembrane transport (GO:1901381)3.62848909
22establishment of mitochondrion localization (GO:0051654)3.55078023
23central nervous system neuron axonogenesis (GO:0021955)3.53792450
24presynaptic membrane assembly (GO:0097105)3.48168872
25cranial nerve morphogenesis (GO:0021602)3.45434990
26ribosomal small subunit assembly (GO:0000028)3.44718260
27regulation of synapse structural plasticity (GO:0051823)3.43994797
28cellular sodium ion homeostasis (GO:0006883)3.41546008
29positive regulation of respiratory burst (GO:0060267)3.40749084
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.28467503
31nucleobase catabolic process (GO:0046113)3.27175332
32presynaptic membrane organization (GO:0097090)3.26462220
33DNA damage response, detection of DNA damage (GO:0042769)3.25140640
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.24152245
35regulation of translation, ncRNA-mediated (GO:0045974)3.24152245
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24152245
37cerebellar granule cell differentiation (GO:0021707)3.23591934
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22431155
39locomotory exploration behavior (GO:0035641)3.21987661
40cell communication by electrical coupling (GO:0010644)3.15805578
41neuron recognition (GO:0008038)3.13440064
42negative regulation of oligodendrocyte differentiation (GO:0048715)3.11528891
43retinal ganglion cell axon guidance (GO:0031290)3.10085036
44positive regulation of synapse assembly (GO:0051965)3.07957075
45synaptic transmission, glutamatergic (GO:0035249)3.03555232
46myelination in peripheral nervous system (GO:0022011)3.03150714
47peripheral nervous system axon ensheathment (GO:0032292)3.03150714
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.99511748
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99009784
50protein localization to cilium (GO:0061512)2.98055048
51potassium ion import (GO:0010107)2.96851707
52exploration behavior (GO:0035640)2.95734467
53cellular response to leptin stimulus (GO:0044320)2.95204437
54protein localization to synapse (GO:0035418)2.94078329
55DNA integration (GO:0015074)2.93637657
56neuron remodeling (GO:0016322)2.93537353
57peptidyl-threonine dephosphorylation (GO:0035970)2.92156047
58brain morphogenesis (GO:0048854)2.92113236
59axonal fasciculation (GO:0007413)2.90541450
60regulation of microtubule-based movement (GO:0060632)2.90455023
61glutamate receptor signaling pathway (GO:0007215)2.87828846
62otic vesicle formation (GO:0030916)2.84606833
63regulation of sarcomere organization (GO:0060297)2.83486513
64cochlea development (GO:0090102)2.82894792
65gamma-aminobutyric acid transport (GO:0015812)2.81502285
66regulation of transmission of nerve impulse (GO:0051969)2.76386766
67protein complex biogenesis (GO:0070271)2.75581503
68regulation of synapse assembly (GO:0051963)2.74874107
69histone H2A acetylation (GO:0043968)2.74222398
70regulation of synaptic transmission, glutamatergic (GO:0051966)2.73976167
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73458092
72cAMP-mediated signaling (GO:0019933)2.73298075
73response to auditory stimulus (GO:0010996)2.71281452
74neural tube formation (GO:0001841)2.69413378
75mitochondrial respiratory chain complex assembly (GO:0033108)2.68502951
76dendrite morphogenesis (GO:0048813)2.66013430
77protein-cofactor linkage (GO:0018065)2.65895650
78response to leptin (GO:0044321)2.65261375
79cell morphogenesis involved in neuron differentiation (GO:0048667)2.64914766
80negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.64181420
81sodium-independent organic anion transport (GO:0043252)2.63761053
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63553541
83intraciliary transport (GO:0042073)2.62834498
84regulation of DNA methylation (GO:0044030)2.61466068
85startle response (GO:0001964)2.60841863
86potassium ion homeostasis (GO:0055075)2.58474890
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54481024
88positive regulation of microtubule polymerization (GO:0031116)2.52244426
89forebrain neuron development (GO:0021884)2.52053486
90atrial cardiac muscle cell action potential (GO:0086014)2.51909511
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50508447
92nephron tubule formation (GO:0072079)2.49421434
93regulation of synapse organization (GO:0050807)2.48019057
94positive regulation of neurological system process (GO:0031646)2.47646580
95neuron-neuron synaptic transmission (GO:0007270)2.46894928
96cell communication involved in cardiac conduction (GO:0086065)2.46302477
97purine nucleobase biosynthetic process (GO:0009113)2.44526613
98cerebral cortex radially oriented cell migration (GO:0021799)2.44286226
99axonogenesis (GO:0007409)2.44111053
100viral transcription (GO:0019083)2.43894260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.93946126
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.86984347
3GBX2_23144817_ChIP-Seq_PC3_Human3.34921318
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.30057025
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.23904810
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80878651
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46021966
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45373654
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.37218315
10FUS_26573619_Chip-Seq_HEK293_Human2.37080575
11IGF1R_20145208_ChIP-Seq_DFB_Human2.29647182
12ZNF274_21170338_ChIP-Seq_K562_Hela2.24814259
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.21296142
14AR_21572438_ChIP-Seq_LNCaP_Human2.20127858
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12269431
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09859171
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09857682
18EWS_26573619_Chip-Seq_HEK293_Human2.09725263
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93538165
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92254797
21REST_21632747_ChIP-Seq_MESCs_Mouse1.91489152
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87066555
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82545632
24P300_19829295_ChIP-Seq_ESCs_Human1.82228978
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78859958
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78859958
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74589913
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73485348
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72225389
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67536427
31SMAD4_21799915_ChIP-Seq_A2780_Human1.65802286
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.63542898
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.62388238
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60964949
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59346052
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56626700
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56195520
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54641123
39AR_25329375_ChIP-Seq_VCAP_Human1.51691001
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51143154
41ELK1_19687146_ChIP-ChIP_HELA_Human1.50837190
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49320585
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.48424754
44TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46033769
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.44904531
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44392305
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.41863386
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40804085
49TAF15_26573619_Chip-Seq_HEK293_Human1.39632306
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.39273482
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38794921
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.38764535
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36669037
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34051290
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.33214209
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32930064
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31270512
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29436366
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18490494
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17086837
61POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.12626346
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12076886
63MYC_18940864_ChIP-ChIP_HL60_Human1.11715269
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.11307307
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10872759
66ER_23166858_ChIP-Seq_MCF-7_Human1.10481582
67TCF4_23295773_ChIP-Seq_U87_Human1.10146383
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08313494
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08313494
70JUN_21703547_ChIP-Seq_K562_Human1.07369554
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05763027
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05568133
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.05023374
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04707086
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04308200
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04190551
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.03748573
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01295369
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.00672047
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00520370
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97175671
82TAL1_26923725_Chip-Seq_HPCs_Mouse0.96952649
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96460305
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96431109
85CBP_20019798_ChIP-Seq_JUKART_Human0.96372916
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96372916
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96160782
88VDR_22108803_ChIP-Seq_LS180_Human0.95922164
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95716102
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.95713826
91RXR_22108803_ChIP-Seq_LS180_Human0.95196028
92NFYB_21822215_ChIP-Seq_K562_Human0.93897470
93STAT3_23295773_ChIP-Seq_U87_Human0.93461090
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93125274
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92800393
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.92426731
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91966908
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91455775
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91433658
100RUNX2_22187159_ChIP-Seq_PCA_Human0.90486053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.69785120
2MP0006292_abnormal_olfactory_placode3.58483972
3MP0002736_abnormal_nociception_after3.21194869
4MP0004270_analgesia2.98307226
5MP0008058_abnormal_DNA_repair2.91022658
6MP0003880_abnormal_central_pattern2.81805933
7MP0000778_abnormal_nervous_system2.72514324
8MP0002234_abnormal_pharynx_morphology2.62393680
9MP0001968_abnormal_touch/_nociception2.30820756
10MP0005423_abnormal_somatic_nervous2.27953996
11MP0004859_abnormal_synaptic_plasticity2.24075873
12MP0008877_abnormal_DNA_methylation2.12268872
13MP0005499_abnormal_olfactory_system2.07125631
14MP0005394_taste/olfaction_phenotype2.07125631
15MP0005187_abnormal_penis_morphology2.01081561
16MP0002822_catalepsy2.00661047
17MP0006276_abnormal_autonomic_nervous1.92077730
18MP0004885_abnormal_endolymph1.90744221
19MP0008789_abnormal_olfactory_epithelium1.86421811
20MP0003635_abnormal_synaptic_transmissio1.85952091
21MP0002734_abnormal_mechanical_nocicepti1.82583509
22MP0004742_abnormal_vestibular_system1.81477793
23MP0002063_abnormal_learning/memory/cond1.80096668
24MP0001502_abnormal_circadian_rhythm1.68544566
25MP0006072_abnormal_retinal_apoptosis1.67033302
26MP0003787_abnormal_imprinting1.66653094
27MP0000049_abnormal_middle_ear1.65026797
28MP0002064_seizures1.59207310
29MP0002272_abnormal_nervous_system1.55744185
30MP0002233_abnormal_nose_morphology1.51159251
31MP0009745_abnormal_behavioral_response1.49763578
32MP0003868_abnormal_feces_composition1.47691603
33MP0005248_abnormal_Harderian_gland1.45590287
34MP0002751_abnormal_autonomic_nervous1.44844991
35MP0002882_abnormal_neuron_morphology1.39779641
36MP0002572_abnormal_emotion/affect_behav1.38330137
37MP0004043_abnormal_pH_regulation1.38291148
38MP0001529_abnormal_vocalization1.37398648
39MP0001486_abnormal_startle_reflex1.33967904
40MP0000631_abnormal_neuroendocrine_gland1.33925326
41MP0003195_calcinosis1.32612438
42MP0004811_abnormal_neuron_physiology1.32436335
43MP0005253_abnormal_eye_physiology1.31975315
44MP0000955_abnormal_spinal_cord1.31503324
45MP0004134_abnormal_chest_morphology1.31410152
46MP0004142_abnormal_muscle_tone1.30889692
47MP0005367_renal/urinary_system_phenotyp1.30493319
48MP0000516_abnormal_urinary_system1.30493319
49MP0002067_abnormal_sensory_capabilities1.30280131
50MP0003938_abnormal_ear_development1.29068039
51MP0002184_abnormal_innervation1.23529302
52MP0001986_abnormal_taste_sensitivity1.21495298
53MP0002102_abnormal_ear_morphology1.21399498
54MP0002638_abnormal_pupillary_reflex1.21037531
55MP0001905_abnormal_dopamine_level1.20531468
56MP0002752_abnormal_somatic_nervous1.20301397
57MP0002152_abnormal_brain_morphology1.19636975
58MP0003861_abnormal_nervous_system1.17556070
59MP0002557_abnormal_social/conspecific_i1.17446015
60MP0005551_abnormal_eye_electrophysiolog1.13923685
61MP0004924_abnormal_behavior1.13850794
62MP0005386_behavior/neurological_phenoty1.13850794
63MP0003755_abnormal_palate_morphology1.13228005
64MP0008569_lethality_at_weaning1.11963178
65MP0003385_abnormal_body_wall1.05836002
66MP0002735_abnormal_chemical_nociception1.05373303
67MP0003315_abnormal_perineum_morphology1.04606539
68MP0003121_genomic_imprinting1.03424248
69MP0001970_abnormal_pain_threshold1.03257548
70MP0003937_abnormal_limbs/digits/tail_de1.01176111
71MP0002733_abnormal_thermal_nociception0.99913233
72MP0008007_abnormal_cellular_replicative0.99473005
73MP0001188_hyperpigmentation0.96876715
74MP0002066_abnormal_motor_capabilities/c0.95403872
75MP0005174_abnormal_tail_pigmentation0.94596744
76MP0005646_abnormal_pituitary_gland0.93683923
77MP0005195_abnormal_posterior_eye0.93470486
78MP0010094_abnormal_chromosome_stability0.90259352
79MP0001963_abnormal_hearing_physiology0.89679995
80MP0003634_abnormal_glial_cell0.88474490
81MP0009046_muscle_twitch0.87995581
82MP0005391_vision/eye_phenotype0.85588564
83MP0001485_abnormal_pinna_reflex0.83474619
84MP0000026_abnormal_inner_ear0.83172591
85MP0002938_white_spotting0.77823082
86MP0002095_abnormal_skin_pigmentation0.77589704
87MP0000920_abnormal_myelination0.77195323
88MP0000647_abnormal_sebaceous_gland0.75898075
89MP0002229_neurodegeneration0.75774573
90MP0000566_synostosis0.74162364
91MP0003879_abnormal_hair_cell0.74141553
92MP0002081_perinatal_lethality0.73423159
93MP0003122_maternal_imprinting0.72736349
94MP0001324_abnormal_eye_pigmentation0.72626054
95MP0010770_preweaning_lethality0.72103456
96MP0002082_postnatal_lethality0.72103456
97MP0002069_abnormal_eating/drinking_beha0.70446939
98MP0001879_abnormal_lymphatic_vessel0.70331793
99MP0004782_abnormal_surfactant_physiolog0.70001828
100MP0003633_abnormal_nervous_system0.69487000

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.50515247
2Hypoglycemic seizures (HP:0002173)4.07833463
3Septo-optic dysplasia (HP:0100842)3.99688899
411 pairs of ribs (HP:0000878)3.92357176
5Hyperventilation (HP:0002883)3.87562753
6Neoplasm of the oral cavity (HP:0100649)3.79378903
7Hypoglycemic coma (HP:0001325)3.58401132
8Reticulocytopenia (HP:0001896)3.55451374
9Abnormality of the septum pellucidum (HP:0007375)3.46435457
10Hepatoblastoma (HP:0002884)3.45854958
11Hyperinsulinemic hypoglycemia (HP:0000825)3.31915999
12Epileptic encephalopathy (HP:0200134)3.20575210
13Medulloblastoma (HP:0002885)3.14331775
14Intestinal atresia (HP:0011100)3.06701223
15Stomach cancer (HP:0012126)3.06175137
16Hypsarrhythmia (HP:0002521)3.03526433
17Drooling (HP:0002307)2.93387457
18EEG with generalized epileptiform discharges (HP:0011198)2.92069291
19Epileptiform EEG discharges (HP:0011182)2.91507568
20Absent septum pellucidum (HP:0001331)2.89839908
21Poor eye contact (HP:0000817)2.88552266
22Oligodactyly (hands) (HP:0001180)2.83913531
23Abnormality of the parietal bone (HP:0002696)2.78618184
24Abnormal social behavior (HP:0012433)2.71025086
25Impaired social interactions (HP:0000735)2.71025086
26Excessive salivation (HP:0003781)2.68149634
27Alacrima (HP:0000522)2.66825202
28Optic nerve hypoplasia (HP:0000609)2.66644243
29Focal motor seizures (HP:0011153)2.65063431
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.61418468
31Pancreatic cysts (HP:0001737)2.55834139
32Aplasia/hypoplasia of the uterus (HP:0008684)2.54687444
33Broad-based gait (HP:0002136)2.52977768
34Decreased lacrimation (HP:0000633)2.46505291
35Fibular aplasia (HP:0002990)2.45261209
36Pancreatic fibrosis (HP:0100732)2.41890007
37Abnormality of the metopic suture (HP:0005556)2.40840809
38Missing ribs (HP:0000921)2.33225656
39Abnormality of the labia minora (HP:0012880)2.32727070
40Volvulus (HP:0002580)2.28422243
41Protruding tongue (HP:0010808)2.26486667
42Abnormality of the astrocytes (HP:0100707)2.25534974
43Astrocytoma (HP:0009592)2.25534974
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23560047
45Symptomatic seizures (HP:0011145)2.15358147
46Horseshoe kidney (HP:0000085)2.12372917
47Oligodactyly (HP:0012165)2.09598388
48True hermaphroditism (HP:0010459)2.08869374
49Prominent metopic ridge (HP:0005487)2.06487010
50Cerebral hypomyelination (HP:0006808)2.06425822
51Hemiparesis (HP:0001269)2.02180100
52Glioma (HP:0009733)2.01722861
53Large earlobe (HP:0009748)1.98778058
54Short phalanx of the thumb (HP:0009660)1.97929231
55Hypoplastic pelvis (HP:0008839)1.96927069
56Papillary thyroid carcinoma (HP:0002895)1.96009649
57Gait imbalance (HP:0002141)1.94175554
58Abnormal hair whorl (HP:0010721)1.93635437
59Atonic seizures (HP:0010819)1.92888321
60Gastrointestinal atresia (HP:0002589)1.92571934
61Nephrogenic diabetes insipidus (HP:0009806)1.91772515
62Abnormality of the pancreatic islet cells (HP:0006476)1.89234204
63Abnormality of endocrine pancreas physiology (HP:0012093)1.89234204
64Increased circulating renin level (HP:0000848)1.87776660
65Short thumb (HP:0009778)1.83275726
66Aqueductal stenosis (HP:0002410)1.82799030
67Hypoplasia of the radius (HP:0002984)1.82450722
68Pachygyria (HP:0001302)1.81800512
69Febrile seizures (HP:0002373)1.79961273
70Aplasia involving forearm bones (HP:0009822)1.78203101
71Absent forearm bone (HP:0003953)1.78203101
72Subacute progressive viral hepatitis (HP:0006572)1.78188029
73Growth hormone deficiency (HP:0000824)1.76640575
74Focal seizures (HP:0007359)1.75941645
75Hepatic necrosis (HP:0002605)1.75794744
76Neoplasm of the adrenal cortex (HP:0100641)1.73789703
77Renal hypoplasia (HP:0000089)1.73208889
78Genital tract atresia (HP:0001827)1.72563383
79Lissencephaly (HP:0001339)1.72137326
80Hemivertebrae (HP:0002937)1.70165724
81Hypoplasia of the uterus (HP:0000013)1.69958417
82Hepatocellular necrosis (HP:0001404)1.69285135
83Congenital malformation of the right heart (HP:0011723)1.68241709
84Double outlet right ventricle (HP:0001719)1.68241709
85Coarctation of aorta (HP:0001680)1.67825071
86Vaginal atresia (HP:0000148)1.67280961
87Partial duplication of thumb phalanx (HP:0009944)1.66840542
88Molar tooth sign on MRI (HP:0002419)1.66829089
89Abnormality of midbrain morphology (HP:0002418)1.66829089
90Fetal akinesia sequence (HP:0001989)1.66786004
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.66754727
92Limb dystonia (HP:0002451)1.66401475
93Thickened helices (HP:0000391)1.66248874
94Congenital primary aphakia (HP:0007707)1.65963247
95Chorioretinal coloboma (HP:0000567)1.65807517
96Scrotal hypoplasia (HP:0000046)1.65472447
97Medial flaring of the eyebrow (HP:0010747)1.62758250
98Esophageal atresia (HP:0002032)1.62276860
99Bicornuate uterus (HP:0000813)1.61786267
100Abnormality of the pons (HP:0007361)1.61019485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.24456404
2MARK14.89736569
3CCNB13.14569951
4SRPK12.87660401
5TAF12.62466245
6MAP3K42.56562567
7MAPK132.50498336
8MAP2K72.34436124
9CSNK1A1L2.29991333
10CSNK1G22.29373087
11CSNK1G32.21199570
12WNK32.09914865
13CSNK1G12.09092314
14NTRK32.07970170
15MAP3K92.00350400
16TNIK1.97164591
17NUAK11.91712412
18NTRK21.87372536
19STK161.85141139
20KSR11.76760404
21PINK11.65686935
22EPHA41.65568545
23RAF11.54559473
24MKNK21.49446701
25TRIM281.46573836
26NTRK11.38882100
27MST41.35658886
28DYRK21.33709873
29BCR1.29695261
30DMPK1.24533846
31EPHB11.17003764
32GRK71.15870633
33WNK11.14157858
34TSSK61.11386023
35DYRK1A1.05805783
36BRAF0.97395806
37PKN10.97005438
38NME10.93621615
39EIF2AK30.93602708
40CAMK1D0.92734869
41MAP2K40.87800580
42AKT30.87733205
43GRK50.83546358
44ARAF0.82206840
45PLK40.81287312
46VRK10.78259186
47VRK20.78032409
48BMPR1B0.76565171
49PRKCG0.73289497
50ERBB40.72786045
51UHMK10.72573847
52FRK0.71516509
53MUSK0.70963529
54FLT30.70960342
55CDK180.70909234
56BRD40.70359836
57CAMK10.70349234
58CDK150.67704197
59CDK140.66378600
60PLK30.65248708
61EPHB20.63945636
62DAPK20.63460250
63INSRR0.62758235
64CDK11A0.62603899
65MKNK10.62507561
66CAMK1G0.61317004
67CDK50.59905498
68PAK30.58476385
69PASK0.56112037
70PHKG20.53749945
71PHKG10.53749945
72PLK20.51918732
73CSNK1A10.51752712
74PRKG10.51311742
75CDC70.50880479
76SGK20.50788675
77CDK30.49875022
78CSNK1E0.49200114
79KSR20.47917074
80TYRO30.44564380
81CSNK1D0.42529269
82ERBB20.40753746
83PRKDC0.40370900
84OBSCN0.40133021
85SGK2230.38802202
86SGK4940.38802202
87MAP3K70.38502987
88ROCK10.37987418
89ATR0.37457960
90CAMK2A0.36027295
91PRKACA0.35400796
92SIK20.35025835
93SIK30.34060924
94PRKCE0.33567617
95ATM0.33006576
96FGFR20.31194164
97ROCK20.30728812
98CDK20.29829267
99MINK10.29157724
100MAPK140.28348747

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.84219746
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43840394
3Ribosome_Homo sapiens_hsa030102.86279095
4Nicotine addiction_Homo sapiens_hsa050332.67073272
5Oxidative phosphorylation_Homo sapiens_hsa001902.10773811
6Insulin secretion_Homo sapiens_hsa049112.10378776
7Non-homologous end-joining_Homo sapiens_hsa034502.03764161
8RNA polymerase_Homo sapiens_hsa030201.82301878
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78268211
10Basal transcription factors_Homo sapiens_hsa030221.75930397
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68195340
12Vitamin B6 metabolism_Homo sapiens_hsa007501.64313710
13Type II diabetes mellitus_Homo sapiens_hsa049301.60245721
14Butanoate metabolism_Homo sapiens_hsa006501.57307159
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57020946
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.56721716
17Steroid biosynthesis_Homo sapiens_hsa001001.52209755
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.50608700
19Circadian rhythm_Homo sapiens_hsa047101.49486172
20Cardiac muscle contraction_Homo sapiens_hsa042601.45771458
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43023543
22Glutamatergic synapse_Homo sapiens_hsa047241.42123631
23Circadian entrainment_Homo sapiens_hsa047131.41302355
24Cocaine addiction_Homo sapiens_hsa050301.40587802
25Protein export_Homo sapiens_hsa030601.38748953
26Synaptic vesicle cycle_Homo sapiens_hsa047211.36661555
27Amphetamine addiction_Homo sapiens_hsa050311.35195288
28Huntingtons disease_Homo sapiens_hsa050161.33989822
29Parkinsons disease_Homo sapiens_hsa050121.33219629
30Caffeine metabolism_Homo sapiens_hsa002321.32896475
31Dopaminergic synapse_Homo sapiens_hsa047281.31561439
32Spliceosome_Homo sapiens_hsa030401.27659760
33GABAergic synapse_Homo sapiens_hsa047271.24715760
34Long-term depression_Homo sapiens_hsa047301.24137443
35Regulation of autophagy_Homo sapiens_hsa041401.23272371
36Long-term potentiation_Homo sapiens_hsa047201.23200139
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22861518
38RNA transport_Homo sapiens_hsa030131.22310229
39RNA degradation_Homo sapiens_hsa030181.21826367
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13448486
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12116874
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10143875
43Axon guidance_Homo sapiens_hsa043601.08751897
44Purine metabolism_Homo sapiens_hsa002301.07015993
45Gastric acid secretion_Homo sapiens_hsa049711.03082599
46Collecting duct acid secretion_Homo sapiens_hsa049661.01926647
47mRNA surveillance pathway_Homo sapiens_hsa030150.96977429
48cAMP signaling pathway_Homo sapiens_hsa040240.96464855
49Alzheimers disease_Homo sapiens_hsa050100.96052765
50Basal cell carcinoma_Homo sapiens_hsa052170.94503587
51Thyroid cancer_Homo sapiens_hsa052160.94093618
52Fanconi anemia pathway_Homo sapiens_hsa034600.93880853
53Inositol phosphate metabolism_Homo sapiens_hsa005620.93574893
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93091915
55Homologous recombination_Homo sapiens_hsa034400.91782115
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88586581
57Taste transduction_Homo sapiens_hsa047420.86016961
58Morphine addiction_Homo sapiens_hsa050320.84804867
59Nitrogen metabolism_Homo sapiens_hsa009100.84243617
60Hedgehog signaling pathway_Homo sapiens_hsa043400.84061888
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80164539
62Serotonergic synapse_Homo sapiens_hsa047260.78516232
63Phototransduction_Homo sapiens_hsa047440.77723172
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77509681
65Endometrial cancer_Homo sapiens_hsa052130.77290950
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76079394
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75949178
68Salivary secretion_Homo sapiens_hsa049700.75105025
69Fatty acid elongation_Homo sapiens_hsa000620.73473723
70Mismatch repair_Homo sapiens_hsa034300.72257880
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70547039
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68500437
73Cholinergic synapse_Homo sapiens_hsa047250.68262109
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66977850
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66934795
76Renin secretion_Homo sapiens_hsa049240.63238943
77Hippo signaling pathway_Homo sapiens_hsa043900.63061986
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62208542
79Thyroid hormone synthesis_Homo sapiens_hsa049180.62197509
80Gap junction_Homo sapiens_hsa045400.61605114
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57920033
82Glucagon signaling pathway_Homo sapiens_hsa049220.55895681
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53682246
84Oxytocin signaling pathway_Homo sapiens_hsa049210.53363274
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51593933
86Oocyte meiosis_Homo sapiens_hsa041140.50972386
87Melanogenesis_Homo sapiens_hsa049160.50527016
88Selenocompound metabolism_Homo sapiens_hsa004500.49803753
89Wnt signaling pathway_Homo sapiens_hsa043100.43954424
90ErbB signaling pathway_Homo sapiens_hsa040120.42401350
91TGF-beta signaling pathway_Homo sapiens_hsa043500.41978995
92Vibrio cholerae infection_Homo sapiens_hsa051100.40995639
93Starch and sucrose metabolism_Homo sapiens_hsa005000.40280946
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38972071
95Estrogen signaling pathway_Homo sapiens_hsa049150.38276004
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37387393
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36876267
98Olfactory transduction_Homo sapiens_hsa047400.36048952
99Alcoholism_Homo sapiens_hsa050340.36030449
100Prolactin signaling pathway_Homo sapiens_hsa049170.34616386

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