SEP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.41964858
2Golgi transport vesicle coating (GO:0048200)9.41964858
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.74069439
4protein retention in ER lumen (GO:0006621)7.21786483
5signal peptide processing (GO:0006465)6.81567475
6proteasome assembly (GO:0043248)5.07692360
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.87743577
8COPII vesicle coating (GO:0048208)4.68836605
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.50913728
10positive regulation of nuclease activity (GO:0032075)4.45005087
11sequestering of metal ion (GO:0051238)4.34287806
12protein maturation by protein folding (GO:0022417)4.29434501
13endoplasmic reticulum unfolded protein response (GO:0030968)4.08664687
14regulation of nuclease activity (GO:0032069)4.06922652
15cellular response to unfolded protein (GO:0034620)3.99511390
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94675725
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94504633
18cellular response to topologically incorrect protein (GO:0035967)3.90324643
19ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.82268970
20protein N-linked glycosylation via asparagine (GO:0018279)3.75286182
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74905110
22ribosome assembly (GO:0042255)3.74401601
23ER-nucleus signaling pathway (GO:0006984)3.74346733
24negative regulation of ligase activity (GO:0051352)3.73573407
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73573407
26vesicle coating (GO:0006901)3.73256075
27peptidyl-asparagine modification (GO:0018196)3.70155972
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69254877
29regulation of cellular amino acid metabolic process (GO:0006521)3.68306645
30keratan sulfate catabolic process (GO:0042340)3.67697787
31protein N-linked glycosylation (GO:0006487)3.47648570
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39860306
33neutrophil activation involved in immune response (GO:0002283)3.37455141
34ATP synthesis coupled proton transport (GO:0015986)3.35217121
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35217121
36ER to Golgi vesicle-mediated transport (GO:0006888)3.32736726
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32062208
38response to endoplasmic reticulum stress (GO:0034976)3.31300572
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26817388
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26817388
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24220383
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24220383
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24220383
44UDP-N-acetylglucosamine metabolic process (GO:0006047)3.21156550
45nucleotide-sugar biosynthetic process (GO:0009226)3.18281426
46peptide catabolic process (GO:0043171)3.18261367
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.15723590
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15723590
49cullin deneddylation (GO:0010388)3.15113300
50protein neddylation (GO:0045116)3.15039136
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13836084
52response to unfolded protein (GO:0006986)3.12194401
53ribosomal large subunit biogenesis (GO:0042273)3.10757099
54cellular response to vitamin D (GO:0071305)3.10513148
55positive regulation of ligase activity (GO:0051351)3.09361195
56response to topologically incorrect protein (GO:0035966)3.07797015
57purine nucleobase biosynthetic process (GO:0009113)3.07722115
584-hydroxyproline metabolic process (GO:0019471)3.07362017
59exocrine pancreas development (GO:0031017)3.06242996
60establishment of integrated proviral latency (GO:0075713)3.05984856
61signal transduction involved in cell cycle checkpoint (GO:0072395)3.05854989
62cell redox homeostasis (GO:0045454)3.04269707
63regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.03003146
64valine metabolic process (GO:0006573)3.01281724
65regulation of metalloenzyme activity (GO:0048552)3.00324225
66GDP-mannose metabolic process (GO:0019673)2.99771976
67cellular response to vitamin (GO:0071295)2.96546760
68protein deneddylation (GO:0000338)2.93303504
69chaperone-mediated protein folding (GO:0061077)2.91379130
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89110007
71regulation of ubiquitin-protein transferase activity (GO:0051438)2.85838385
72protein autoprocessing (GO:0016540)2.84756001
73regulation of integrin-mediated signaling pathway (GO:2001044)2.84399722
74regulation of ligase activity (GO:0051340)2.83340942
75transcription elongation from RNA polymerase III promoter (GO:0006385)2.81242704
76termination of RNA polymerase III transcription (GO:0006386)2.81242704
77pentose-phosphate shunt (GO:0006098)2.80607960
78collagen fibril organization (GO:0030199)2.80602883
79respiratory electron transport chain (GO:0022904)2.80124885
80nucleotide-sugar metabolic process (GO:0009225)2.79041981
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78257736
82NADPH regeneration (GO:0006740)2.78158150
83respiratory chain complex IV assembly (GO:0008535)2.77896303
84protein targeting to mitochondrion (GO:0006626)2.74536829
85purine nucleotide salvage (GO:0032261)2.71768764
86protein targeting to ER (GO:0045047)2.71719840
87cotranslational protein targeting to membrane (GO:0006613)2.70650146
88electron transport chain (GO:0022900)2.69830426
89negative regulation of protein ubiquitination (GO:0031397)2.69814781
90peptidyl-proline hydroxylation (GO:0019511)2.68244189
91apoptotic cell clearance (GO:0043277)2.67671126
92nucleoside salvage (GO:0043174)2.67666502
93formation of translation preinitiation complex (GO:0001731)2.66237585
94ER overload response (GO:0006983)2.64889408
95oxidative phosphorylation (GO:0006119)2.64691801
96protein localization to endoplasmic reticulum (GO:0070972)2.64488966
97mitochondrial calcium ion transport (GO:0006851)2.63083520
98regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.62997523
99establishment of viral latency (GO:0019043)2.62054125
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61908125
101regulation of cellular amine metabolic process (GO:0033238)2.61508525
102tricarboxylic acid metabolic process (GO:0072350)2.59195404
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58492316
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.58144093
105nucleobase biosynthetic process (GO:0046112)2.58050262
106antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.57660300
107misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.56634382
108deoxyribonucleotide biosynthetic process (GO:0009263)2.56433158
109proline biosynthetic process (GO:0006561)2.56245199
110peptidyl-histidine modification (GO:0018202)2.55725992
111negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.55194647
112peptide hormone processing (GO:0016486)2.54871535
113tRNA aminoacylation (GO:0043039)2.54619218
114amino acid activation (GO:0043038)2.54619218
1152-deoxyribonucleotide biosynthetic process (GO:0009265)2.53733042
116deoxyribose phosphate biosynthetic process (GO:0046385)2.53733042
117positive regulation of cell cycle arrest (GO:0071158)2.52953531
118translation (GO:0006412)2.52735757
119chaperone-mediated protein transport (GO:0072321)2.52393788
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52319949
121membrane budding (GO:0006900)2.51822296
122tRNA aminoacylation for protein translation (GO:0006418)2.51454395
123regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51120568
124glycerol ether metabolic process (GO:0006662)2.50402975
125IMP biosynthetic process (GO:0006188)2.48939506
126protein localization to mitochondrion (GO:0070585)2.47783151
127tricarboxylic acid cycle (GO:0006099)2.47687049
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47266588
129cell adhesion mediated by integrin (GO:0033627)2.44913667
130peptidyl-proline modification (GO:0018208)2.44768387
131rRNA modification (GO:0000154)2.44080343
132negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43862126
133protein peptidyl-prolyl isomerization (GO:0000413)2.43634374
134pteridine-containing compound biosynthetic process (GO:0042559)2.42709243
135type B pancreatic cell proliferation (GO:0044342)2.42400891
136regulation of mitochondrial translation (GO:0070129)2.42391846
137folic acid-containing compound biosynthetic process (GO:0009396)2.42258059
138maturation of 5.8S rRNA (GO:0000460)2.41770875
139AMP metabolic process (GO:0046033)2.41561068
140cytochrome complex assembly (GO:0017004)2.40857005
141dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37547716
142response to testosterone (GO:0033574)2.36725977
143Arp2/3 complex-mediated actin nucleation (GO:0034314)2.36129771
144response to misfolded protein (GO:0051788)2.35240145
145maintenance of protein localization in organelle (GO:0072595)2.34764657
146endosome to pigment granule transport (GO:0043485)2.34073405
147endosome to melanosome transport (GO:0035646)2.34073405
148glycosphingolipid catabolic process (GO:0046479)2.32453466
149establishment of protein localization to mitochondrion (GO:0072655)2.32262702
150collagen metabolic process (GO:0032963)2.32040842
151maternal placenta development (GO:0001893)2.31440043
152Golgi organization (GO:0007030)2.31348017
153purine-containing compound salvage (GO:0043101)2.31335618
154ether metabolic process (GO:0018904)2.30652821
155toxin metabolic process (GO:0009404)2.29660410
156lactate metabolic process (GO:0006089)2.28558810
157G1/S transition of mitotic cell cycle (GO:0000082)2.27349443
158cell cycle G1/S phase transition (GO:0044843)2.27349443
159DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.27196338
160nucleobase-containing small molecule interconversion (GO:0015949)2.26987066
161deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.26941228
162L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.26490744
163fucose metabolic process (GO:0006004)2.25595991
164negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.25153146
165collagen catabolic process (GO:0030574)2.24346003
166positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.23289502
167endocrine pancreas development (GO:0031018)2.22329892
168multicellular organismal catabolic process (GO:0044243)2.20650752
169regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.20429584
170negative regulation of glycoprotein metabolic process (GO:1903019)2.19436177
171glucose catabolic process (GO:0006007)2.19220497
172protein hydroxylation (GO:0018126)2.18628200
173* protein folding (GO:0006457)2.17930093
174type B pancreatic cell development (GO:0003323)2.17276104
175hydrogen peroxide catabolic process (GO:0042744)2.17249047
176multicellular organismal metabolic process (GO:0044236)2.17216162
177positive regulation of glycoprotein metabolic process (GO:1903020)2.16929614
178regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.15351036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92219205
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36702080
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.30596069
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.99046539
5CLOCK_20551151_ChIP-Seq_293T_Human2.98469890
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84249254
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73735082
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66983299
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65705499
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.45859973
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44655328
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32077940
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31851880
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27977210
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11749031
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10610994
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08554480
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05652707
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.99808287
20E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98530904
21DCP1A_22483619_ChIP-Seq_HELA_Human1.94496666
22ZFX_18555785_ChIP-Seq_MESCs_Mouse1.93942108
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93119389
24GATA1_22025678_ChIP-Seq_K562_Human1.88200753
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88153301
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84132248
27AR_21909140_ChIP-Seq_LNCAP_Human1.82324786
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80185681
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.78869179
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75026746
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74905468
32ELK1_19687146_ChIP-ChIP_HELA_Human1.73375425
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72420296
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72399618
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71606189
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.68196498
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66947600
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.66536592
39TFEB_21752829_ChIP-Seq_HELA_Human1.66487102
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64964179
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61196048
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59154159
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.58251873
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54353086
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54310987
46GABP_19822575_ChIP-Seq_HepG2_Human1.54265179
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54166362
48VDR_23849224_ChIP-Seq_CD4+_Human1.51792786
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.50355466
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50101421
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49143361
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49027756
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48727202
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47151521
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46921226
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46847303
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46323497
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44786655
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.42918254
60TTF2_22483619_ChIP-Seq_HELA_Human1.42526939
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42167967
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.42085409
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39398315
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39087571
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38923881
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38657617
67XRN2_22483619_ChIP-Seq_HELA_Human1.37635381
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35578770
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.35100865
70E2F7_22180533_ChIP-Seq_HELA_Human1.33986213
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33098412
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32318795
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31159925
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30420191
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29917919
76SOX2_20726797_ChIP-Seq_SW620_Human1.28906570
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.25257019
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24434281
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.21477460
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21129800
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19005168
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19003274
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18801114
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17607303
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16770484
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15294703
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14519997
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14180287
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12867961
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12684756
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11332301
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08995687
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08468954
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08252836
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.08018322
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07894673
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06999375
98ATF3_27146783_Chip-Seq_COLON_Human1.06797551
99ELF5_23300383_ChIP-Seq_T47D_Human1.05801395
100FOXP3_21729870_ChIP-Seq_TREG_Human1.05337909
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05273887
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04846609
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03904291
104SOX17_20123909_ChIP-Seq_XEN_Mouse1.03796955
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03510331
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03507037
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.02433666
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02364441
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01763771
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01378008
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00973681
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99587140
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97950239
114SPI1_23547873_ChIP-Seq_NB4_Human0.97536127
115GATA4_25053715_ChIP-Seq_YYC3_Human0.95329224
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94878091
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93810301
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93756267
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93632651
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93616449
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.93251076
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93002216
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92746970
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92158550
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91636921
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.91215235
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.90078837
128EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89481394
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89316584
130SALL4_22934838_ChIP-ChIP_CD34+_Human0.88067815
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86228923
132MYB_26560356_Chip-Seq_TH2_Human0.86160867
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82630779
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82431859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.67420623
2MP0006054_spinal_hemorrhage3.98944958
3MP0005275_abnormal_skin_tensile3.11559787
4MP0005503_abnormal_tendon_morphology2.90408068
5MP0001835_abnormal_antigen_presentation2.46671065
6MP0003705_abnormal_hypodermis_morpholog2.43773731
7MP0003806_abnormal_nucleotide_metabolis2.41408552
8MP0002877_abnormal_melanocyte_morpholog2.41265449
9MP0003195_calcinosis2.40901950
10MP0000013_abnormal_adipose_tissue2.34119043
11MP0003279_aneurysm2.32242533
12MP0005220_abnormal_exocrine_pancreas2.30399621
13MP0001958_emphysema2.25716838
14MP0004272_abnormal_basement_membrane2.19114364
15MP0005058_abnormal_lysosome_morphology2.16336257
16MP0009785_altered_susceptibility_to2.15577340
17MP0006082_CNS_inflammation2.07358039
18MP0003186_abnormal_redox_activity2.04105726
19MP0002148_abnormal_hypersensitivity_rea2.02498544
20MP0006036_abnormal_mitochondrial_physio2.01759814
21MP0009697_abnormal_copulation1.97676601
22MP0003786_premature_aging1.86741205
23MP0009384_cardiac_valve_regurgitation1.85266307
24MP0003300_gastrointestinal_ulcer1.75754118
25MP0008058_abnormal_DNA_repair1.75038794
26MP0010094_abnormal_chromosome_stability1.66257098
27MP0005671_abnormal_response_to1.63297609
28MP0001542_abnormal_bone_strength1.61187420
29MP0002295_abnormal_pulmonary_circulatio1.58961548
30MP0002896_abnormal_bone_mineralization1.57303182
31MP0003183_abnormal_peptide_metabolism1.56992898
32MP0009333_abnormal_splenocyte_physiolog1.54613001
33MP0005023_abnormal_wound_healing1.49400760
34MP0002139_abnormal_hepatobiliary_system1.48129190
35MP0003566_abnormal_cell_adhesion1.47974379
36MP0009643_abnormal_urine_homeostasis1.47754369
37MP0002006_tumorigenesis1.45137161
38MP0005000_abnormal_immune_tolerance1.43235006
39MP0005408_hypopigmentation1.39498325
40MP0001944_abnormal_pancreas_morphology1.37775213
41MP0004147_increased_porphyrin_level1.35927294
42MP0010352_gastrointestinal_tract_polyps1.35456606
43MP0001533_abnormal_skeleton_physiology1.35081133
44MP0009840_abnormal_foam_cell1.35018111
45MP0002419_abnormal_innate_immunity1.33748063
46MP0001845_abnormal_inflammatory_respons1.33303493
47MP0003283_abnormal_digestive_organ1.31605449
48MP0002090_abnormal_vision1.31517577
49MP0005084_abnormal_gallbladder_morpholo1.28795254
50MP0005464_abnormal_platelet_physiology1.28657121
51MP0001666_abnormal_nutrient_absorption1.27831680
52MP0000685_abnormal_immune_system1.25917191
53MP0010368_abnormal_lymphatic_system1.23982353
54MP0002060_abnormal_skin_morphology1.23278443
55MP0002452_abnormal_antigen_presenting1.22967140
56MP0000343_altered_response_to1.22948207
57MP0002132_abnormal_respiratory_system1.22922505
58MP0003448_altered_tumor_morphology1.22545837
59MP0001756_abnormal_urination1.22333315
60MP0004043_abnormal_pH_regulation1.22241045
61MP0010155_abnormal_intestine_physiology1.21080420
62MP0003795_abnormal_bone_structure1.17940962
63MP0005508_abnormal_skeleton_morphology1.17909665
64MP0003077_abnormal_cell_cycle1.17524605
65MP0001790_abnormal_immune_system1.16398409
66MP0005387_immune_system_phenotype1.16398409
67MP0003724_increased_susceptibility_to1.13591247
68MP0009780_abnormal_chondrocyte_physiolo1.13106655
69MP0005025_abnormal_response_to1.11471302
70MP0005365_abnormal_bile_salt1.11087946
71MP0005083_abnormal_biliary_tract1.10152969
72MP0002693_abnormal_pancreas_physiology1.09590401
73MP0002396_abnormal_hematopoietic_system1.09232634
74MP0002723_abnormal_immune_serum1.09166581
75MP0002933_joint_inflammation1.09145005
76MP0005390_skeleton_phenotype1.08676541
77MP0001764_abnormal_homeostasis1.08621172
78MP0003075_altered_response_to1.07305358
79MP0005085_abnormal_gallbladder_physiolo1.06345631
80MP0001800_abnormal_humoral_immune1.05599287
81MP0001243_abnormal_dermal_layer1.05324118
82MP0003111_abnormal_nucleus_morphology1.04353659
83MP0000163_abnormal_cartilage_morphology1.03299865
84MP0008932_abnormal_embryonic_tissue1.02666489
85MP0002420_abnormal_adaptive_immunity0.99525331
86MP0004782_abnormal_surfactant_physiolog0.98860567
87MP0005332_abnormal_amino_acid0.98720705
88MP0001819_abnormal_immune_cell0.98622112
89MP0005636_abnormal_mineral_homeostasis0.98210956
90MP0003656_abnormal_erythrocyte_physiolo0.98069465
91MP0003191_abnormal_cellular_cholesterol0.97194890
92MP0000003_abnormal_adipose_tissue0.97138896
93MP0000490_abnormal_crypts_of0.96518376
94MP0001879_abnormal_lymphatic_vessel0.95031712
95MP0000465_gastrointestinal_hemorrhage0.94884428
96MP0005166_decreased_susceptibility_to0.94177941
97MP0003950_abnormal_plasma_membrane0.93972945
98MP0000858_altered_metastatic_potential0.93930909
99MP0003252_abnormal_bile_duct0.93894301
100MP0008873_increased_physiological_sensi0.92492766
101MP0002115_abnormal_skeleton_extremities0.92070324
102MP0003693_abnormal_embryo_hatching0.91906748
103MP0005164_abnormal_response_to0.91785006
104MP0010386_abnormal_urinary_bladder0.91559925
105MP0005379_endocrine/exocrine_gland_phen0.91301515
106MP0009764_decreased_sensitivity_to0.89805883
107MP0002405_respiratory_system_inflammati0.88451606
108MP0003718_maternal_effect0.88351529
109MP0001661_extended_life_span0.87589801
110MP0000372_irregular_coat_pigmentation0.86938645
111MP0005360_urolithiasis0.86323658
112MP0010234_abnormal_vibrissa_follicle0.86288585
113MP0003172_abnormal_lysosome_physiology0.85633763
114MP0004957_abnormal_blastocyst_morpholog0.84530231
115MP0002113_abnormal_skeleton_development0.84160509
116MP0000689_abnormal_spleen_morphology0.84141321
117MP0005257_abnormal_intraocular_pressure0.84029162
118MP0005075_abnormal_melanosome_morpholog0.83954289
119MP0001881_abnormal_mammary_gland0.83507240
120MP0009763_increased_sensitivity_to0.83320054
121MP0002909_abnormal_adrenal_gland0.82078776
122MP0004134_abnormal_chest_morphology0.82026811
123MP0005319_abnormal_enzyme/_coenzyme0.81970225
124MP0002928_abnormal_bile_duct0.81225382
125MP0002019_abnormal_tumor_incidence0.79260556
126MP0002398_abnormal_bone_marrow0.79075675
127MP0000358_abnormal_cell_content/0.78497336
128MP0002168_other_aberrant_phenotype0.78390105
129MP0008260_abnormal_autophagy0.77289196
130MP0003436_decreased_susceptibility_to0.74075813
131MP0000598_abnormal_liver_morphology0.73741166
132MP0005165_increased_susceptibility_to0.71204311
133MP0002998_abnormal_bone_remodeling0.70459348
134MP0004264_abnormal_extraembryonic_tissu0.70380175
135MP0008007_abnormal_cellular_replicative0.70370442
136MP0001299_abnormal_eye_distance/0.69503260
137MP0002166_altered_tumor_susceptibility0.68534990
138MP0002078_abnormal_glucose_homeostasis0.67840528
139MP0002135_abnormal_kidney_morphology0.67787769
140MP0008004_abnormal_stomach_pH0.65973622
141MP0000613_abnormal_salivary_gland0.65739803
142MP0002136_abnormal_kidney_physiology0.65424241
143MP0000609_abnormal_liver_physiology0.65053560
144MP0001915_intracranial_hemorrhage0.64929670
145MP0003091_abnormal_cell_migration0.63551213
146MP0002282_abnormal_trachea_morphology0.63322506
147MP0000767_abnormal_smooth_muscle0.63290077
148MP0001853_heart_inflammation0.62518180
149MP0008469_abnormal_protein_level0.60348338
150MP0003868_abnormal_feces_composition0.59240591
151MP0000681_abnormal_thyroid_gland0.59116951
152MP0003959_abnormal_lean_body0.58898009
153MP0001765_abnormal_ion_homeostasis0.57932981
154MP0000537_abnormal_urethra_morphology0.57414179

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.73006384
2Premature rupture of membranes (HP:0001788)4.45979505
3Cervical subluxation (HP:0003308)3.88486972
4Beaking of vertebral bodies (HP:0004568)3.81451875
5Hypoglycemic coma (HP:0001325)3.66912323
6Vacuolated lymphocytes (HP:0001922)3.55132496
7Abnormality of the intrinsic pathway (HP:0010989)3.49416856
8Vertebral compression fractures (HP:0002953)3.40853577
9Abnormality of glycolipid metabolism (HP:0010969)3.33609764
10Abnormality of liposaccharide metabolism (HP:0010968)3.33609764
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.33609764
12Generalized aminoaciduria (HP:0002909)3.29129231
13Increased hepatocellular lipid droplets (HP:0006565)3.27104064
14Dysostosis multiplex (HP:0000943)3.26727178
15Acute necrotizing encephalopathy (HP:0006965)3.24009494
16Abnormality of methionine metabolism (HP:0010901)3.18285438
17Urinary glycosaminoglycan excretion (HP:0003541)3.10028845
18Mucopolysacchariduria (HP:0008155)3.10028845
19Soft skin (HP:0000977)3.04904221
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03059103
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03059103
22Thoracolumbar scoliosis (HP:0002944)2.95586779
23Lipid accumulation in hepatocytes (HP:0006561)2.95458015
24Abnormal mitochondria in muscle tissue (HP:0008316)2.94706574
25Aortic dissection (HP:0002647)2.94586587
26Progressive macrocephaly (HP:0004481)2.93602875
27Increased CSF lactate (HP:0002490)2.91898267
28Mitochondrial inheritance (HP:0001427)2.90603966
29Hepatic necrosis (HP:0002605)2.90364487
30Renal Fanconi syndrome (HP:0001994)2.88918823
31Abnormality of dentin (HP:0010299)2.84508906
32Aortic aneurysm (HP:0004942)2.82682649
33Acute encephalopathy (HP:0006846)2.80202485
34Ankle contracture (HP:0006466)2.80097683
35Hepatocellular necrosis (HP:0001404)2.73246530
36Biconcave vertebral bodies (HP:0004586)2.70627284
37Wormian bones (HP:0002645)2.67669934
38Abnormal protein glycosylation (HP:0012346)2.65209244
39Abnormal glycosylation (HP:0012345)2.65209244
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65209244
41Abnormal protein N-linked glycosylation (HP:0012347)2.65209244
42Nonimmune hydrops fetalis (HP:0001790)2.65187971
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59988699
44Abnormality of polysaccharide metabolism (HP:0011012)2.59988699
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59988699
46Hypoglycemic seizures (HP:0002173)2.59026102
47Cerebral edema (HP:0002181)2.57149452
48Palpitations (HP:0001962)2.55908182
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55357399
50Disinhibition (HP:0000734)2.54703251
51Joint stiffness (HP:0001387)2.50907894
52Exertional dyspnea (HP:0002875)2.43858906
53Platyspondyly (HP:0000926)2.43820512
54Increased serum pyruvate (HP:0003542)2.42723066
55Abnormal foot bone ossification (HP:0010675)2.42414602
56Hepatosplenomegaly (HP:0001433)2.41082393
57Poor head control (HP:0002421)2.39160746
58Epiphyseal dysplasia (HP:0002656)2.36602852
59Blue sclerae (HP:0000592)2.33168543
60B lymphocytopenia (HP:0010976)2.33142914
61Nausea (HP:0002018)2.33046034
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30978245
63Abnormal tarsal ossification (HP:0008369)2.29843580
64Type I transferrin isoform profile (HP:0003642)2.28673059
65Atrophic scars (HP:0001075)2.27208017
66Megaloblastic anemia (HP:0001889)2.26580000
67Conjunctival hamartoma (HP:0100780)2.24688835
68Abnormal umbilical cord blood vessels (HP:0011403)2.22939590
69Single umbilical artery (HP:0001195)2.22939590
70Abnormality of the fetal cardiovascular system (HP:0010948)2.22939590
713-Methylglutaconic aciduria (HP:0003535)2.22496905
72Peritonitis (HP:0002586)2.22412600
73Hyperinsulinemic hypoglycemia (HP:0000825)2.22087366
74Respiratory failure (HP:0002878)2.20975008
75Protuberant abdomen (HP:0001538)2.19936384
76Hypoplasia of the odontoid process (HP:0003311)2.19691542
77Abnormality of the acetabulum (HP:0003170)2.19678463
78Reduced antithrombin III activity (HP:0001976)2.19481284
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18957482
80Abnormality of the common coagulation pathway (HP:0010990)2.18688091
81Symptomatic seizures (HP:0011145)2.18347227
82Agnosia (HP:0010524)2.17183265
83Increased serum lactate (HP:0002151)2.15885298
84Lactic acidosis (HP:0003128)2.14510413
85Dilatation of the ascending aorta (HP:0005111)2.13559677
86Increased intramyocellular lipid droplets (HP:0012240)2.13357942
87Recurrent abscess formation (HP:0002722)2.12967340
88Abnormal cartilage morphology (HP:0002763)2.11773153
89Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10832576
90Methylmalonic acidemia (HP:0002912)2.10451284
91Abnormality of glycolysis (HP:0004366)2.08776502
92Glucose intolerance (HP:0000833)2.08703030
93Vascular tortuosity (HP:0004948)2.08631338
94Petechiae (HP:0000967)2.08476498
95Hypokinesia (HP:0002375)2.07561295
96Osteolytic defects of the hand bones (HP:0009699)2.06683000
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.06683000
98Posterior subcapsular cataract (HP:0007787)2.06600447
99Abnormality of the umbilical cord (HP:0010881)2.03397513
100Thrombocytosis (HP:0001894)2.02742027
101Esophageal neoplasm (HP:0100751)2.00949589
102Neoplasm of head and neck (HP:0012288)2.00949589
103Disproportionate short-trunk short stature (HP:0003521)2.00554206
104Osteoarthritis (HP:0002758)2.00194095
105Ketoacidosis (HP:0001993)1.98584162
106Abnormality of B cell number (HP:0010975)1.96398627
107Hypoproteinemia (HP:0003075)1.95705410
108Abnormality of vitamin B metabolism (HP:0004340)1.94050992
109CNS demyelination (HP:0007305)1.93318195
110Rough bone trabeculation (HP:0100670)1.92942902
111Exercise intolerance (HP:0003546)1.92548797
112Lethargy (HP:0001254)1.91738141
113Abnormality of the odontoid process (HP:0003310)1.91119675
114Abnormality of fatty-acid metabolism (HP:0004359)1.90363082
115Abnormality of the anterior horn cell (HP:0006802)1.90208887
116Degeneration of anterior horn cells (HP:0002398)1.90208887
117Glycosuria (HP:0003076)1.90079947
118Abnormality of urine glucose concentration (HP:0011016)1.90079947
119Cerebral aneurysm (HP:0004944)1.89258992
120Cupped ribs (HP:0000887)1.88950450
121Secondary amenorrhea (HP:0000869)1.88879588
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.88792653
123Steatorrhea (HP:0002570)1.88763870
124Tetraparesis (HP:0002273)1.88509892
125Increased cerebral lipofuscin (HP:0011813)1.88258282
126Abnormality of the distal phalanges of the toes (HP:0010182)1.86858624
127Irregular vertebral endplates (HP:0003301)1.86647082
128Reduced subcutaneous adipose tissue (HP:0003758)1.85857479
129Congenital, generalized hypertrichosis (HP:0004540)1.85666938
130Progressive external ophthalmoplegia (HP:0000590)1.85061669
131Microvesicular hepatic steatosis (HP:0001414)1.84832185
132Abnormality of the basal ganglia (HP:0002134)1.84636366
133Metaphyseal dysplasia (HP:0100255)1.84380821
134T lymphocytopenia (HP:0005403)1.83711203
135Abnormality of the calcaneus (HP:0008364)1.83657638
136Ovoid vertebral bodies (HP:0003300)1.83624947
137Abnormalities of placenta or umbilical cord (HP:0001194)1.83598536
138Patchy hypopigmentation of hair (HP:0011365)1.83145621
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.83127427
140Axonal loss (HP:0003447)1.83017966
141Abnormality of renal resorption (HP:0011038)1.82816747
142Abnormality of the lumbar spine (HP:0100712)1.82004425
143Loss of speech (HP:0002371)1.81883072
144Respiratory difficulties (HP:0002880)1.80768052
145Interstitial pulmonary disease (HP:0006530)1.80765877
146Methylmalonic aciduria (HP:0012120)1.79608124
147Aplastic anemia (HP:0001915)1.79468658
148Severe short stature (HP:0003510)1.79026534
149Macrocytic anemia (HP:0001972)1.78941370
150Upper motor neuron abnormality (HP:0002127)1.78793901
151Abdominal distention (HP:0003270)1.78680764
152Microretrognathia (HP:0000308)1.77923315
153Late onset (HP:0003584)1.77833298
154Coxa vara (HP:0002812)1.77454499
155Arterial tortuosity (HP:0005116)1.76178074
156Bladder diverticulum (HP:0000015)1.76024018
157Progressive neurologic deterioration (HP:0002344)1.75903526
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73303857
159Neonatal short-limb short stature (HP:0008921)1.72973813
160Fragile skin (HP:0001030)1.72874777
161Back pain (HP:0003418)1.70728965
162Spinal rigidity (HP:0003306)1.70538900
163Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68820851
164Epiphyseal stippling (HP:0010655)1.67165497
165Metaphyseal cupping (HP:0003021)1.66716986
166Ectopia lentis (HP:0001083)1.65120639
167Thin bony cortex (HP:0002753)1.65022467
168Vertebral hypoplasia (HP:0008417)1.64662048
169Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64662048
170Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.62767819
171Hyperglycemia (HP:0003074)1.62703733
172Chondrocalcinosis (HP:0000934)1.62325365
173Follicular hyperkeratosis (HP:0007502)1.61858218
174Multiple enchondromatosis (HP:0005701)1.61295669
175Abnormality of subcutaneous fat tissue (HP:0001001)1.60290875
176Irregular epiphyses (HP:0010582)1.59900612
177Coxa valga (HP:0002673)1.59897498
178Gout (HP:0001997)1.59885092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.44677825
2ERN13.33803601
3MAP3K123.08423133
4TESK12.98524346
5EIF2AK32.95257727
6NME22.90849029
7BCKDK2.86521539
8TESK22.69607869
9TRIB32.62743804
10PASK2.57456825
11EIF2AK12.23569701
12FRK2.23177792
13SRPK12.18065697
14LIMK12.14784327
15BMPR22.12411005
16FLT32.00332376
17TRIM281.95033527
18LRRK21.94750539
19MST41.69046665
20PAK41.65548395
21PIM21.62693796
22CAMKK21.60243115
23PIK3CG1.54612799
24KDR1.53722356
25TSSK61.53586423
26RPS6KA41.52529025
27BRSK21.49330100
28PKN21.48697755
29MAP3K31.45253337
30DDR21.45186657
31NEK91.43177042
32VRK21.41880860
33SIK31.41742578
34MAPK151.41350871
35MET1.40020430
36PDGFRA1.37526608
37INSRR1.33998135
38EPHA21.29784840
39TGFBR21.28331280
40MAP3K141.27883346
41PTK61.27324363
42TTK1.25481802
43BUB11.16890436
44ILK1.16622174
45TAOK31.14103678
46MAPKAPK31.12628477
47PLK31.12397030
48TRPM71.09589810
49ERBB31.07463091
50TTN1.06638767
51PAK21.06562112
52MAP3K21.05267250
53MKNK10.99726619
54MYLK0.99632095
55BMPR1B0.98917187
56ARAF0.98657738
57PTK20.98516268
58STK160.98119626
59MOS0.97793289
60EPHA30.97078844
61WNK40.96501867
62ERBB40.94826887
63TGFBR10.93726500
64NEK10.86662332
65ZAP700.86388970
66FER0.85264601
67LATS10.83358127
68EIF2AK20.80339631
69MAP3K80.79933645
70SIK10.78357019
71TBK10.77573262
72STK100.75908974
73MAP2K30.75896135
74PLK40.75397072
75CDK60.74428353
76DYRK30.73579299
77PRKG20.71602223
78MAP2K20.70943750
79VRK10.70452059
80CLK10.69835464
81PBK0.67836239
82PDK20.67182159
83BCR0.64344816
84TXK0.63961173
85JAK30.63016580
86ABL20.62937588
87DAPK10.62545488
88DYRK1B0.62226094
89HIPK20.61904073
90WEE10.61866583
91NTRK10.60172527
92TEC0.59002706
93EPHB10.56428557
94MAP2K60.55870236
95CSNK1G10.55129603
96BRAF0.54830724
97ACVR1B0.54277497
98GRK10.53968231
99STK40.53766980
100PLK10.52184153
101MST1R0.50348715
102CSNK2A10.49902162
103RPS6KB20.49632911
104NUAK10.49486130
105CSNK2A20.49095474
106PAK10.48799113
107JAK10.48311458
108STK30.48011893
109GRK70.47809060
110AURKB0.46074574
111CCNB10.44812076
112TYK20.44072087
113BTK0.43509681
114EEF2K0.43439456
115MAPKAPK50.43312090
116MAP2K10.40645810
117MKNK20.40604962
118IKBKB0.37480354
119TIE10.37028960
120KIT0.35978371
121BRSK10.35889874
122IRAK10.35633720
123PAK30.35254913
124LYN0.34359002
125CDK90.34177057
126CSNK1G30.33770413
127CSNK1A1L0.31796729
128ALK0.29982074
129ZAK0.29964962
130CSF1R0.29735806
131RET0.29348320
132IGF1R0.28927157
133GSK3A0.28872411
134ABL10.28669564
135PLK20.28261031
136IRAK30.27613875
137NLK0.27257541
138CSNK1G20.26001082
139CDK80.25701427
140PRKCI0.25438980

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.95043570
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.57525411
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.45839116
4Sulfur metabolism_Homo sapiens_hsa009203.12553945
5N-Glycan biosynthesis_Homo sapiens_hsa005102.82708913
6Oxidative phosphorylation_Homo sapiens_hsa001902.63773430
7Proteasome_Homo sapiens_hsa030502.28951250
8Folate biosynthesis_Homo sapiens_hsa007902.17310342
9Other glycan degradation_Homo sapiens_hsa005112.15512806
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11109509
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08871891
12Lysosome_Homo sapiens_hsa041422.08688943
13Parkinsons disease_Homo sapiens_hsa050122.07302115
14RNA polymerase_Homo sapiens_hsa030201.90065471
15Selenocompound metabolism_Homo sapiens_hsa004501.87105023
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78848033
17Non-homologous end-joining_Homo sapiens_hsa034501.72939067
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71177993
19Asthma_Homo sapiens_hsa053101.70945125
20Vibrio cholerae infection_Homo sapiens_hsa051101.57894789
21Allograft rejection_Homo sapiens_hsa053301.54386036
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52404406
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.50754151
24ECM-receptor interaction_Homo sapiens_hsa045121.50236307
25Autoimmune thyroid disease_Homo sapiens_hsa053201.46778242
26Type I diabetes mellitus_Homo sapiens_hsa049401.42443333
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41378324
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33212320
29Graft-versus-host disease_Homo sapiens_hsa053321.33158458
30Huntingtons disease_Homo sapiens_hsa050161.31787951
31Protein digestion and absorption_Homo sapiens_hsa049741.31520714
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30900714
33Spliceosome_Homo sapiens_hsa030401.27625264
34Glutathione metabolism_Homo sapiens_hsa004801.26815182
35Rheumatoid arthritis_Homo sapiens_hsa053231.25379620
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23406425
37Alzheimers disease_Homo sapiens_hsa050101.22756698
38Homologous recombination_Homo sapiens_hsa034401.21976025
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21544360
40Vitamin B6 metabolism_Homo sapiens_hsa007501.21122915
41Fatty acid degradation_Homo sapiens_hsa000711.19158966
42Legionellosis_Homo sapiens_hsa051341.14766442
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13288578
44Collecting duct acid secretion_Homo sapiens_hsa049661.13018744
45Propanoate metabolism_Homo sapiens_hsa006401.12055787
46DNA replication_Homo sapiens_hsa030301.11249147
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09309268
48Ribosome_Homo sapiens_hsa030101.06199419
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03582359
50Antigen processing and presentation_Homo sapiens_hsa046121.03298176
51Renin-angiotensin system_Homo sapiens_hsa046141.02479216
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00975573
53Basal transcription factors_Homo sapiens_hsa030220.99173882
54Phagosome_Homo sapiens_hsa041450.98402099
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96526900
56RNA degradation_Homo sapiens_hsa030180.94652065
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94461874
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94366076
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.92920527
60Peroxisome_Homo sapiens_hsa041460.92848153
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92805743
62Focal adhesion_Homo sapiens_hsa045100.89908684
63Galactose metabolism_Homo sapiens_hsa000520.89253014
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88657299
65Pyruvate metabolism_Homo sapiens_hsa006200.85934317
66Purine metabolism_Homo sapiens_hsa002300.85751325
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85055236
68Viral myocarditis_Homo sapiens_hsa054160.85046808
69Carbon metabolism_Homo sapiens_hsa012000.83985292
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82014186
71Staphylococcus aureus infection_Homo sapiens_hsa051500.79797728
72Fatty acid metabolism_Homo sapiens_hsa012120.78445269
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78051383
74Arginine and proline metabolism_Homo sapiens_hsa003300.77994423
75Fatty acid elongation_Homo sapiens_hsa000620.77044478
76Starch and sucrose metabolism_Homo sapiens_hsa005000.75576513
77Caffeine metabolism_Homo sapiens_hsa002320.74809689
78Malaria_Homo sapiens_hsa051440.74353975
79Pyrimidine metabolism_Homo sapiens_hsa002400.74086216
80Sulfur relay system_Homo sapiens_hsa041220.74061537
81Hematopoietic cell lineage_Homo sapiens_hsa046400.72055060
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.71705344
83Pentose phosphate pathway_Homo sapiens_hsa000300.70318923
84One carbon pool by folate_Homo sapiens_hsa006700.69574719
85Tryptophan metabolism_Homo sapiens_hsa003800.69545009
86Steroid biosynthesis_Homo sapiens_hsa001000.69160674
87Sphingolipid metabolism_Homo sapiens_hsa006000.68212116
88Bladder cancer_Homo sapiens_hsa052190.64026165
89Nucleotide excision repair_Homo sapiens_hsa034200.62933420
90Herpes simplex infection_Homo sapiens_hsa051680.61015619
91Arachidonic acid metabolism_Homo sapiens_hsa005900.60661757
92p53 signaling pathway_Homo sapiens_hsa041150.59954193
93Thyroid cancer_Homo sapiens_hsa052160.59886061
94Biosynthesis of amino acids_Homo sapiens_hsa012300.59651072
95Shigellosis_Homo sapiens_hsa051310.59011668
96Histidine metabolism_Homo sapiens_hsa003400.58020302
97Small cell lung cancer_Homo sapiens_hsa052220.58013798
98Fat digestion and absorption_Homo sapiens_hsa049750.55492910
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53812387
100Leishmaniasis_Homo sapiens_hsa051400.53479440
101Systemic lupus erythematosus_Homo sapiens_hsa053220.50748317
102Thyroid hormone synthesis_Homo sapiens_hsa049180.50428188
103Epstein-Barr virus infection_Homo sapiens_hsa051690.50366645
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49949683
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49658284
106Complement and coagulation cascades_Homo sapiens_hsa046100.49322088
107Metabolic pathways_Homo sapiens_hsa011000.48565153
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46978069
109Viral carcinogenesis_Homo sapiens_hsa052030.45578097
110Mismatch repair_Homo sapiens_hsa034300.45281701
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.44211026
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.43528118
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.42875336
114Amoebiasis_Homo sapiens_hsa051460.42722113
115Pertussis_Homo sapiens_hsa051330.42606835
116Cell cycle_Homo sapiens_hsa041100.40948764
117Base excision repair_Homo sapiens_hsa034100.40677914
118Mineral absorption_Homo sapiens_hsa049780.40342882
119Apoptosis_Homo sapiens_hsa042100.40199534
120Butanoate metabolism_Homo sapiens_hsa006500.39721863
121Proteoglycans in cancer_Homo sapiens_hsa052050.37904620
122Vitamin digestion and absorption_Homo sapiens_hsa049770.37206139
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37047636
124beta-Alanine metabolism_Homo sapiens_hsa004100.36307339
125Regulation of autophagy_Homo sapiens_hsa041400.35860958
126Fructose and mannose metabolism_Homo sapiens_hsa000510.35636335
127Chemical carcinogenesis_Homo sapiens_hsa052040.34883436
128PPAR signaling pathway_Homo sapiens_hsa033200.34878781
129Prion diseases_Homo sapiens_hsa050200.34524178
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34177649
131TGF-beta signaling pathway_Homo sapiens_hsa043500.32860579
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30401112
133RNA transport_Homo sapiens_hsa030130.29949096

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