SENP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.53298933
2serotonin metabolic process (GO:0042428)5.02858402
3neuronal action potential (GO:0019228)4.87868681
4primary amino compound metabolic process (GO:1901160)4.83985416
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29668046
6presynaptic membrane assembly (GO:0097105)4.01245673
7histone H4-K12 acetylation (GO:0043983)3.91751805
8response to pheromone (GO:0019236)3.82559928
9neural tube formation (GO:0001841)3.74857124
10regulation of action potential (GO:0098900)3.61990141
11indole-containing compound metabolic process (GO:0042430)3.60740877
12presynaptic membrane organization (GO:0097090)3.52763212
13pyrimidine nucleobase catabolic process (GO:0006208)3.51045141
14gamma-aminobutyric acid transport (GO:0015812)3.50851582
15somite development (GO:0061053)3.41945785
16startle response (GO:0001964)3.41433074
17epithelial cilium movement (GO:0003351)3.35667312
18postsynaptic membrane organization (GO:0001941)3.35326275
19behavioral response to ethanol (GO:0048149)3.32845482
20L-fucose catabolic process (GO:0042355)3.29510569
21fucose catabolic process (GO:0019317)3.29510569
22L-fucose metabolic process (GO:0042354)3.29510569
23histone H3-K4 trimethylation (GO:0080182)3.24339857
24mesenchymal cell differentiation involved in kidney development (GO:0072161)3.14784853
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.14784853
26superoxide anion generation (GO:0042554)3.14726487
27piRNA metabolic process (GO:0034587)3.05702112
28action potential (GO:0001508)3.03825655
29G-protein coupled receptor internalization (GO:0002031)3.03622084
30activated T cell proliferation (GO:0050798)3.03048422
31membrane depolarization during action potential (GO:0086010)3.02445266
32indole-containing compound catabolic process (GO:0042436)3.02026318
33indolalkylamine catabolic process (GO:0046218)3.02026318
34tryptophan catabolic process (GO:0006569)3.02026318
35protein polyglutamylation (GO:0018095)2.99430808
36neuron cell-cell adhesion (GO:0007158)2.98227193
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96541469
38indolalkylamine metabolic process (GO:0006586)2.94765433
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94337293
40righting reflex (GO:0060013)2.93004981
41forebrain neuron differentiation (GO:0021879)2.92336513
42kynurenine metabolic process (GO:0070189)2.92115207
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91338710
44positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.88416084
45regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.87265877
46positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.87265877
47negative regulation of mast cell activation (GO:0033004)2.85885874
48transmission of nerve impulse (GO:0019226)2.85118595
49detection of light stimulus involved in visual perception (GO:0050908)2.84093865
50detection of light stimulus involved in sensory perception (GO:0050962)2.84093865
51regulation of non-canonical Wnt signaling pathway (GO:2000050)2.81689457
52nucleobase catabolic process (GO:0046113)2.80786246
53DNA deamination (GO:0045006)2.80112874
54hindbrain development (GO:0030902)2.78284417
55regulation of germinal center formation (GO:0002634)2.77392732
56cilium movement (GO:0003341)2.73935901
57limb bud formation (GO:0060174)2.71757906
58sulfation (GO:0051923)2.70848746
59regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.69612437
60positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.69612437
61cytoplasmic mRNA processing body assembly (GO:0033962)2.67839676
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67797120
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66145605
64seminiferous tubule development (GO:0072520)2.64727805
65auditory behavior (GO:0031223)2.63256508
66positive regulation of potassium ion transmembrane transport (GO:1901381)2.61591104
67dentate gyrus development (GO:0021542)2.60902609
68cell differentiation in spinal cord (GO:0021515)2.60003121
69cerebral cortex radially oriented cell migration (GO:0021799)2.58828700
70tryptophan metabolic process (GO:0006568)2.57587253
71synaptic transmission, cholinergic (GO:0007271)2.57241648
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56471386
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56441885
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.55518793
75positive regulation of sodium ion transmembrane transport (GO:1902307)2.55144343
76endoderm formation (GO:0001706)2.55135433
77axoneme assembly (GO:0035082)2.54844114
78interkinetic nuclear migration (GO:0022027)2.54560451
79regulation of timing of cell differentiation (GO:0048505)2.53894068
80keratinocyte development (GO:0003334)2.52615974
81retina layer formation (GO:0010842)2.52205935
82regulation of platelet aggregation (GO:0090330)2.51913022
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.51364853
84protein localization to cilium (GO:0061512)2.51091255
85limb development (GO:0060173)2.50666232
86appendage development (GO:0048736)2.50666232
87regulation of DNA endoreduplication (GO:0032875)2.49896372
88spinal cord development (GO:0021510)2.49762063
89cell proliferation in forebrain (GO:0021846)2.49557280
90negative regulation of DNA-dependent DNA replication (GO:2000104)2.49396122
91DNA methylation involved in gamete generation (GO:0043046)2.49239880
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48967926
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.48967926
94regulation of translation, ncRNA-mediated (GO:0045974)2.48967926
95retinal ganglion cell axon guidance (GO:0031290)2.46906011
96cilium organization (GO:0044782)2.46851280
97glutamate receptor signaling pathway (GO:0007215)2.45388786
98sympathetic nervous system development (GO:0048485)2.45035690
99regulation of mesoderm development (GO:2000380)2.44340198
100regulation of cilium movement (GO:0003352)2.43546985
101positive regulation of mRNA catabolic process (GO:0061014)2.43190180
102axonemal dynein complex assembly (GO:0070286)2.40986221
103mesenchymal cell differentiation (GO:0048762)2.39578157
104cilium assembly (GO:0042384)2.37689254
105embryonic epithelial tube formation (GO:0001838)2.37120181
106cellular ketone body metabolic process (GO:0046950)2.36866787
107central nervous system projection neuron axonogenesis (GO:0021952)2.36568763
108positive regulation of oligodendrocyte differentiation (GO:0048714)2.35470759
109cornea development in camera-type eye (GO:0061303)2.35255332
110reflex (GO:0060004)2.34748250
111negative regulation of homotypic cell-cell adhesion (GO:0034111)2.34705712
112parturition (GO:0007567)2.34555489
113negative regulation of systemic arterial blood pressure (GO:0003085)2.34344196
114photoreceptor cell development (GO:0042461)2.33893301
115cyclic nucleotide catabolic process (GO:0009214)2.33784459
116regulation of memory T cell differentiation (GO:0043380)2.32587806
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30925301
118cAMP catabolic process (GO:0006198)2.29022286
119dendritic cell chemotaxis (GO:0002407)2.28112692
120protein localization to synapse (GO:0035418)2.28069843
121negative regulation of myoblast differentiation (GO:0045662)2.28033397
122dendritic cell migration (GO:0036336)2.26337345
123lymphoid progenitor cell differentiation (GO:0002320)2.26025417
124positive regulation of uterine smooth muscle contraction (GO:0070474)2.25501210
125photoreceptor cell maintenance (GO:0045494)2.25371272
126inner ear receptor stereocilium organization (GO:0060122)2.24960334
127phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.24559170
128positive regulation of synapse assembly (GO:0051965)2.23788570
129cell differentiation involved in kidney development (GO:0061005)2.23697945
130energy homeostasis (GO:0097009)2.22863826
131centriole assembly (GO:0098534)2.22347758
132DNA integration (GO:0015074)2.21666927
133cell differentiation involved in metanephros development (GO:0072202)2.21561159
134regulation of glutamate receptor signaling pathway (GO:1900449)2.19275365
135developmental pigmentation (GO:0048066)2.19249511
136regulation of synapse assembly (GO:0051963)2.19239560
137nonmotile primary cilium assembly (GO:0035058)2.19228216
138neurotransmitter-gated ion channel clustering (GO:0072578)2.18941679
139germinal center formation (GO:0002467)2.18257295
140negative regulation of T-helper cell differentiation (GO:0045623)2.18108143
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.18108143
142negative regulation of keratinocyte proliferation (GO:0010839)2.16862761
143modulation by virus of host process (GO:0019054)2.16281629
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15808154
145definitive hemopoiesis (GO:0060216)2.15687713
146vocalization behavior (GO:0071625)2.15338133
147regulation of respiratory gaseous exchange (GO:0043576)2.14802191
148synaptic transmission, glutamatergic (GO:0035249)2.14747682
149regulation of pigment cell differentiation (GO:0050932)2.14505159
150female gonad development (GO:0008585)2.13728071
151interferon-gamma production (GO:0032609)2.13563958
152central nervous system neuron axonogenesis (GO:0021955)2.13424155
153positive regulation of cardiac muscle cell differentiation (GO:2000727)2.12583304
154extracellular negative regulation of signal transduction (GO:1900116)2.11957379
155extracellular regulation of signal transduction (GO:1900115)2.11957379
156cranial nerve structural organization (GO:0021604)2.11781771
157cranial nerve morphogenesis (GO:0021602)2.11728529
158generation of neurons (GO:0048699)2.11592822
159regulation of respiratory system process (GO:0044065)2.11254438
160spinal cord motor neuron differentiation (GO:0021522)2.11062607
161mechanosensory behavior (GO:0007638)2.10202871
162face development (GO:0060324)2.09763207
163regulation of development, heterochronic (GO:0040034)2.09610789
164kidney morphogenesis (GO:0060993)2.08770130
165negative regulation of osteoblast proliferation (GO:0033689)2.08322234
166calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.07328460
167neuron-neuron synaptic transmission (GO:0007270)2.06954985
168atrial cardiac muscle cell action potential (GO:0086014)2.06824875
169CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.05829076
170positive regulation of action potential (GO:0045760)2.05703200
171cilium or flagellum-dependent cell motility (GO:0001539)2.04865816
172histone H3-K36 demethylation (GO:0070544)2.04132162
173microtubule depolymerization (GO:0007019)2.03808990
174cerebellar Purkinje cell differentiation (GO:0021702)2.03740440
175negative regulation of stem cell proliferation (GO:2000647)2.03567062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.06063378
2EZH2_22144423_ChIP-Seq_EOC_Human3.39556490
3ZNF274_21170338_ChIP-Seq_K562_Hela2.91897584
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79022572
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67747602
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53440117
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34103652
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26309297
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.22803565
10IGF1R_20145208_ChIP-Seq_DFB_Human2.20221143
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14927417
12TAF15_26573619_Chip-Seq_HEK293_Human2.09476914
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07291089
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03707975
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.03103483
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00512016
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00401854
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97182496
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.96839322
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95662147
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92958640
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91890640
23P300_19829295_ChIP-Seq_ESCs_Human1.91705440
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91282845
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.90043519
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.88963511
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87659418
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.86058452
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83766876
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.81605113
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.79617012
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79589232
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76828247
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.75176999
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73988774
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.73321149
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.73214298
38SMAD4_21799915_ChIP-Seq_A2780_Human1.72182408
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70974122
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.68711902
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.67013309
42P53_22387025_ChIP-Seq_ESCs_Mouse1.66971400
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66931405
44FUS_26573619_Chip-Seq_HEK293_Human1.66789476
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64458290
46REST_21632747_ChIP-Seq_MESCs_Mouse1.61950203
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57392366
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.55570715
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55434246
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54430852
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.53970937
52AR_21572438_ChIP-Seq_LNCaP_Human1.53400474
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53223789
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53223789
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53153679
56RNF2_27304074_Chip-Seq_NSC_Mouse1.52332364
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51747545
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50207074
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.49903713
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48845155
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48243302
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48243302
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48014391
64P300_18555785_Chip-Seq_ESCs_Mouse1.47686503
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46937084
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46610503
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46544752
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.46178762
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.45793565
70ER_23166858_ChIP-Seq_MCF-7_Human1.45277648
71STAT3_23295773_ChIP-Seq_U87_Human1.43197601
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.39999206
73* EWS_26573619_Chip-Seq_HEK293_Human1.39089323
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39057669
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38740308
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.37967539
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37760442
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.36608853
79BCAT_22108803_ChIP-Seq_LS180_Human1.36091845
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35404883
81DROSHA_22980978_ChIP-Seq_HELA_Human1.34267019
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.33768040
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33408228
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33180083
85CBP_20019798_ChIP-Seq_JUKART_Human1.33180083
86* TCF4_23295773_ChIP-Seq_U87_Human1.32534283
87PU1_27457419_Chip-Seq_LIVER_Mouse1.30435922
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30250591
89VDR_22108803_ChIP-Seq_LS180_Human1.30121450
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.29569161
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29516850
92IRF1_19129219_ChIP-ChIP_H3396_Human1.28389813
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27573464
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26096262
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26056739
96CTCF_18555785_Chip-Seq_ESCs_Mouse1.25029161
97AR_25329375_ChIP-Seq_VCAP_Human1.24922659
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.24154328
99* TAL1_26923725_Chip-Seq_HPCs_Mouse1.23647721
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.22877016
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21930280
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21205682
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20962828
104TP53_18474530_ChIP-ChIP_U2OS_Human1.20758100
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20757608
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20512303
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.19018179
108* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18719323
109* RUNX2_22187159_ChIP-Seq_PCA_Human1.18024980
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17958900
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17561207
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15799166
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15191736
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14807458
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.13401997
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12088166
117TP53_22573176_ChIP-Seq_HFKS_Human1.10539634
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.10084725
119TCF4_22108803_ChIP-Seq_LS180_Human1.09561618
120KDM2B_26808549_Chip-Seq_REH_Human1.08574466
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.06226447
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06185179
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05090698
124* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02120026
125NANOG_19829295_ChIP-Seq_ESCs_Human1.00552151
126SOX2_19829295_ChIP-Seq_ESCs_Human1.00552151
127REST_18959480_ChIP-ChIP_MESCs_Mouse1.00216543
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99610103
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99408715
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98069340
131* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97189204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.56694214
2MP0003136_yellow_coat_color3.46932787
3MP0003787_abnormal_imprinting3.44450913
4MP0005409_darkened_coat_color3.05996245
5MP0006292_abnormal_olfactory_placode2.91955208
6MP0000566_synostosis2.83034160
7MP0005171_absent_coat_pigmentation2.55296754
8MP0003880_abnormal_central_pattern2.54741292
9MP0002102_abnormal_ear_morphology2.40068120
10MP0000015_abnormal_ear_pigmentation2.36424536
11MP0000569_abnormal_digit_pigmentation2.33250097
12MP0004885_abnormal_endolymph2.32926632
13MP0003195_calcinosis2.11869320
14MP0005174_abnormal_tail_pigmentation2.09180326
15MP0005646_abnormal_pituitary_gland2.08011768
16MP0005645_abnormal_hypothalamus_physiol1.96849343
17MP0004381_abnormal_hair_follicle1.96116838
18MP0004133_heterotaxia1.94234491
19MP0003646_muscle_fatigue1.84609181
20MP0001986_abnormal_taste_sensitivity1.70891955
21MP0001486_abnormal_startle_reflex1.70700962
22MP0009046_muscle_twitch1.66095706
23MP0001485_abnormal_pinna_reflex1.61649442
24MP0002735_abnormal_chemical_nociception1.60726645
25MP0002163_abnormal_gland_morphology1.58423071
26MP0003890_abnormal_embryonic-extraembry1.53386437
27MP0001968_abnormal_touch/_nociception1.52002555
28MP0003283_abnormal_digestive_organ1.50352587
29MP0002837_dystrophic_cardiac_calcinosis1.50044099
30MP0004145_abnormal_muscle_electrophysio1.48384304
31MP0002876_abnormal_thyroid_physiology1.48006222
32MP0009745_abnormal_behavioral_response1.47836619
33MP0003121_genomic_imprinting1.45529832
34MP0002277_abnormal_respiratory_mucosa1.44116220
35MP0005423_abnormal_somatic_nervous1.42298445
36MP0002095_abnormal_skin_pigmentation1.41788658
37MP0002009_preneoplasia1.41258757
38MP0002733_abnormal_thermal_nociception1.39016508
39MP0005379_endocrine/exocrine_gland_phen1.37170228
40MP0006276_abnormal_autonomic_nervous1.35243744
41MP0002928_abnormal_bile_duct1.34433007
42MP0003183_abnormal_peptide_metabolism1.33854622
43MP0003941_abnormal_skin_development1.33707512
44MP0004924_abnormal_behavior1.33408367
45MP0005386_behavior/neurological_phenoty1.33408367
46MP0004742_abnormal_vestibular_system1.32373893
47MP0000778_abnormal_nervous_system1.31471398
48MP0001984_abnormal_olfaction1.31210221
49MP0002067_abnormal_sensory_capabilities1.30881945
50MP0002653_abnormal_ependyma_morphology1.30234218
51MP0004270_analgesia1.30143346
52MP0003635_abnormal_synaptic_transmissio1.29746155
53MP0000383_abnormal_hair_follicle1.28354649
54MP0000427_abnormal_hair_cycle1.27507374
55MP0003011_delayed_dark_adaptation1.27121084
56MP0001346_abnormal_lacrimal_gland1.26229457
57MP0002736_abnormal_nociception_after1.26092992
58MP0005389_reproductive_system_phenotype1.24739704
59MP0000631_abnormal_neuroendocrine_gland1.24676156
60MP0002572_abnormal_emotion/affect_behav1.24647163
61MP0002822_catalepsy1.23935182
62MP0002638_abnormal_pupillary_reflex1.23664619
63MP0002557_abnormal_social/conspecific_i1.23654678
64MP0008872_abnormal_physiological_respon1.23189678
65MP0002938_white_spotting1.23022270
66MP0005551_abnormal_eye_electrophysiolog1.21976500
67MP0003119_abnormal_digestive_system1.20820238
68MP0004859_abnormal_synaptic_plasticity1.20696824
69MP0000372_irregular_coat_pigmentation1.18603470
70MP0005187_abnormal_penis_morphology1.18157037
71MP0002184_abnormal_innervation1.17884781
72MP0003122_maternal_imprinting1.17766831
73MP0001502_abnormal_circadian_rhythm1.14941298
74MP0000026_abnormal_inner_ear1.14428697
75MP0002177_abnormal_outer_ear1.13641759
76MP0008877_abnormal_DNA_methylation1.12794076
77MP0004043_abnormal_pH_regulation1.10063740
78MP0000955_abnormal_spinal_cord1.09091217
79MP0005671_abnormal_response_to1.08797040
80MP0003938_abnormal_ear_development1.08520827
81MP0002160_abnormal_reproductive_system1.07045033
82MP0001501_abnormal_sleep_pattern1.06059554
83MP0002063_abnormal_learning/memory/cond1.05261468
84MP0002272_abnormal_nervous_system1.04346682
85MP0001963_abnormal_hearing_physiology1.01757709
86MP0002064_seizures1.01290720
87MP0005503_abnormal_tendon_morphology0.99781990
88MP0000049_abnormal_middle_ear0.98948100
89MP0009250_abnormal_appendicular_skeleto0.98156877
90MP0002234_abnormal_pharynx_morphology0.97513030
91MP0005195_abnormal_posterior_eye0.97465346
92MP0001919_abnormal_reproductive_system0.97276083
93MP0001529_abnormal_vocalization0.96670665
94MP0002882_abnormal_neuron_morphology0.95440747
95MP0008058_abnormal_DNA_repair0.94629944
96MP0000681_abnormal_thyroid_gland0.93061102
97MP0002249_abnormal_larynx_morphology0.92941269
98MP0002734_abnormal_mechanical_nocicepti0.92291059
99MP0009697_abnormal_copulation0.91293258
100MP0005084_abnormal_gallbladder_morpholo0.91217452
101MP0004130_abnormal_muscle_cell0.90764125
102MP0006072_abnormal_retinal_apoptosis0.89501814
103MP0002751_abnormal_autonomic_nervous0.87269169
104MP0005075_abnormal_melanosome_morpholog0.86536158
105MP0004142_abnormal_muscle_tone0.86174433
106MP0001790_abnormal_immune_system0.85305941
107MP0005387_immune_system_phenotype0.85305941
108MP0004147_increased_porphyrin_level0.84305944
109MP0008995_early_reproductive_senescence0.82039202
110MP0008875_abnormal_xenobiotic_pharmacok0.82032089
111MP0001186_pigmentation_phenotype0.80524176
112MP0005253_abnormal_eye_physiology0.79636961
113MP0008569_lethality_at_weaning0.78270147
114MP0005499_abnormal_olfactory_system0.77393842
115MP0005394_taste/olfaction_phenotype0.77393842
116MP0008789_abnormal_olfactory_epithelium0.76896482
117MP0001324_abnormal_eye_pigmentation0.76706622
118MP0005367_renal/urinary_system_phenotyp0.75388571
119MP0000516_abnormal_urinary_system0.75388571
120MP0003763_abnormal_thymus_physiology0.74806419
121MP0002752_abnormal_somatic_nervous0.73790139
122MP0003698_abnormal_male_reproductive0.73651299
123MP0008260_abnormal_autophagy0.72567565
124MP0010386_abnormal_urinary_bladder0.72408478
125MP0001664_abnormal_digestion0.72108228
126MP0001293_anophthalmia0.71704868
127MP0001835_abnormal_antigen_presentation0.71679015
128MP0001440_abnormal_grooming_behavior0.71634921
129MP0002152_abnormal_brain_morphology0.71605204
130MP0002229_neurodegeneration0.71094126
131MP0001905_abnormal_dopamine_level0.71066838
132MP0002132_abnormal_respiratory_system0.70757906
133MP0005257_abnormal_intraocular_pressure0.69303227
134MP0002116_abnormal_craniofacial_bone0.66512083
135MP0000579_abnormal_nail_morphology0.66251806
136MP0003937_abnormal_limbs/digits/tail_de0.64950751
137MP0002075_abnormal_coat/hair_pigmentati0.64596365
138MP0003755_abnormal_palate_morphology0.63557856
139MP0001970_abnormal_pain_threshold0.63529377

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68798778
2Pancreatic cysts (HP:0001737)4.35500194
3Chromsome breakage (HP:0040012)4.18366537
4Febrile seizures (HP:0002373)4.12943807
5Aplasia cutis congenita (HP:0001057)3.00327619
6Focal motor seizures (HP:0011153)2.99158957
7Abnormal hair whorl (HP:0010721)2.87323576
8Abnormality of the renal cortex (HP:0011035)2.81923321
9Abnormality of incisor morphology (HP:0011063)2.81795578
10White forelock (HP:0002211)2.78136646
11Genetic anticipation (HP:0003743)2.75224325
12Absent/shortened dynein arms (HP:0200106)2.74589763
13Dynein arm defect of respiratory motile cilia (HP:0012255)2.74589763
14Type II lissencephaly (HP:0007260)2.68539205
15Inability to walk (HP:0002540)2.60590092
16Cystic liver disease (HP:0006706)2.57503781
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57442865
18Abnormality of alanine metabolism (HP:0010916)2.57442865
19Hyperalaninemia (HP:0003348)2.57442865
20Patchy hypopigmentation of hair (HP:0011365)2.56844596
21Abnormality of the nasal septum (HP:0000419)2.53124395
22Prostate neoplasm (HP:0100787)2.53002682
23Congenital stationary night blindness (HP:0007642)2.51964881
24Lip pit (HP:0100267)2.50028030
25Septo-optic dysplasia (HP:0100842)2.49287919
26Protruding tongue (HP:0010808)2.48958088
27Hypothermia (HP:0002045)2.48605902
28Abolished electroretinogram (ERG) (HP:0000550)2.46205985
29Progressive inability to walk (HP:0002505)2.44504136
30Focal seizures (HP:0007359)2.41626753
31Abnormal ciliary motility (HP:0012262)2.41210565
32Tubular atrophy (HP:0000092)2.35861350
33Abnormality of the axillary hair (HP:0100134)2.34185419
34Abnormality of secondary sexual hair (HP:0009888)2.34185419
35Ectopic kidney (HP:0000086)2.28251107
36Abnormality of the renal collecting system (HP:0004742)2.27605332
37Attenuation of retinal blood vessels (HP:0007843)2.27261845
38Genital tract atresia (HP:0001827)2.24557166
39Hemiparesis (HP:0001269)2.21326368
40Furrowed tongue (HP:0000221)2.21069556
41Male pseudohermaphroditism (HP:0000037)2.21022325
42Increased corneal curvature (HP:0100692)2.19824822
43Keratoconus (HP:0000563)2.19824822
44Vaginal atresia (HP:0000148)2.19156084
45Sclerocornea (HP:0000647)2.18420735
46Optic nerve hypoplasia (HP:0000609)2.18128783
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17282815
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.16055974
49Duplicated collecting system (HP:0000081)2.15071545
50Congenital hepatic fibrosis (HP:0002612)2.13871994
51Lissencephaly (HP:0001339)2.13526741
52Epileptic encephalopathy (HP:0200134)2.11705708
53Tubulointerstitial nephritis (HP:0001970)2.09344206
54Absent speech (HP:0001344)2.09089742
55Agitation (HP:0000713)2.08795418
56Congenital, generalized hypertrichosis (HP:0004540)2.08521401
57Medial flaring of the eyebrow (HP:0010747)2.08164298
58Abnormal drinking behavior (HP:0030082)2.07481597
59Polydipsia (HP:0001959)2.07481597
60Pendular nystagmus (HP:0012043)2.05968550
61Broad-based gait (HP:0002136)2.05592249
62Midline defect of the nose (HP:0004122)2.05040230
63Clubbing of toes (HP:0100760)2.02787930
64Nephroblastoma (Wilms tumor) (HP:0002667)2.02088144
65Clumsiness (HP:0002312)2.00832248
66Retrobulbar optic neuritis (HP:0100654)1.98464428
67Optic neuritis (HP:0100653)1.98464428
68Anencephaly (HP:0002323)1.98379658
69Chronic hepatic failure (HP:0100626)1.97925446
70Abnormality of DNA repair (HP:0003254)1.96025829
71Median cleft lip (HP:0000161)1.95005618
72True hermaphroditism (HP:0010459)1.94605050
73Exotropia (HP:0000577)1.94317606
74Meckel diverticulum (HP:0002245)1.94204795
75Abnormal respiratory epithelium morphology (HP:0012253)1.94107787
76Abnormal respiratory motile cilium morphology (HP:0005938)1.94107787
77Chorioretinal atrophy (HP:0000533)1.93552887
78Abnormality of the preputium (HP:0100587)1.93454347
79Renal cortical cysts (HP:0000803)1.93411581
80Nephronophthisis (HP:0000090)1.93175461
81Volvulus (HP:0002580)1.92561074
82Preaxial hand polydactyly (HP:0001177)1.91989245
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.91813601
84Patellar aplasia (HP:0006443)1.91322160
85Nasolacrimal duct obstruction (HP:0000579)1.91185374
86Abnormal respiratory motile cilium physiology (HP:0012261)1.91126864
87Abnormality of the renal medulla (HP:0100957)1.91096147
88Mesomelia (HP:0003027)1.91038726
89Embryonal renal neoplasm (HP:0011794)1.90570653
90Concave nail (HP:0001598)1.89875780
91Fair hair (HP:0002286)1.89089291
92Abnormal rod and cone electroretinograms (HP:0008323)1.88883195
93Abnormality of the ileum (HP:0001549)1.87946696
94Abnormality of the fingertips (HP:0001211)1.87875393
95Abnormality of the nasolacrimal system (HP:0000614)1.86049362
96Abnormality of the lacrimal duct (HP:0011481)1.85989856
97Morphological abnormality of the middle ear (HP:0008609)1.84814110
98Dialeptic seizures (HP:0011146)1.84498118
99Hyperventilation (HP:0002883)1.83979104
100Poor coordination (HP:0002370)1.82882908
101Atonic seizures (HP:0010819)1.82819910
102Submucous cleft hard palate (HP:0000176)1.82706279
103Aplasia/Hypoplasia of the patella (HP:0006498)1.82366017
104Pancreatic fibrosis (HP:0100732)1.82326243
105Agammaglobulinemia (HP:0004432)1.81084367
106Congenital sensorineural hearing impairment (HP:0008527)1.80853021
107Ulnar claw (HP:0001178)1.80844993
108Abnormality of the incisor (HP:0000676)1.80692276
109Postaxial hand polydactyly (HP:0001162)1.80629868
110Oligodactyly (hands) (HP:0001180)1.80580780
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80016330
112Thyroiditis (HP:0100646)1.79179490
113Generalized hypopigmentation of hair (HP:0011358)1.79137538
114Nephrogenic diabetes insipidus (HP:0009806)1.78999367
115Limb dystonia (HP:0002451)1.77860462
116Gait imbalance (HP:0002141)1.76939140
117Blue irides (HP:0000635)1.76662167
118Gaze-evoked nystagmus (HP:0000640)1.76207721
119Abnormality of the columella (HP:0009929)1.76160147
120Progressive cerebellar ataxia (HP:0002073)1.75671777
121Alveolar cell carcinoma (HP:0006519)1.75655982
122Tubulointerstitial fibrosis (HP:0005576)1.73751001
123Large for gestational age (HP:0001520)1.73400954
124Chronic sinusitis (HP:0011109)1.72040686
125Specific learning disability (HP:0001328)1.71595556
126Excessive salivation (HP:0003781)1.71364911
127Drooling (HP:0002307)1.71364911
128Duplication of thumb phalanx (HP:0009942)1.71150056
129Postaxial foot polydactyly (HP:0001830)1.71142900
130Congenital primary aphakia (HP:0007707)1.70938593
131Abnormality of midbrain morphology (HP:0002418)1.70637059
132Molar tooth sign on MRI (HP:0002419)1.70637059
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.69907432
134Hypoplastic ischia (HP:0003175)1.69801127
135Pachygyria (HP:0001302)1.69059267
136Bile duct proliferation (HP:0001408)1.68090923
137Abnormal biliary tract physiology (HP:0012439)1.68090923
138Recurrent cutaneous fungal infections (HP:0011370)1.67992068
139Chronic mucocutaneous candidiasis (HP:0002728)1.67992068
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67674870
141Absent eyebrow (HP:0002223)1.67016975
142Growth hormone deficiency (HP:0000824)1.66915633
143Absent septum pellucidum (HP:0001331)1.66632748
144Cupped ear (HP:0000378)1.65833244
145Upper limb muscle weakness (HP:0003484)1.65677735
146Decreased central vision (HP:0007663)1.65290677
147Small hand (HP:0200055)1.64780590
148Panhypogammaglobulinemia (HP:0003139)1.64338518
149Abnormal delayed hypersensitivity skin test (HP:0002963)1.64003194
150Ventricular fibrillation (HP:0001663)1.63941658
151Abnormality of salivation (HP:0100755)1.63719103
152Stomach cancer (HP:0012126)1.63239966
153Abnormality of the parietal bone (HP:0002696)1.62188663
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62010459
155Short tibia (HP:0005736)1.61644444
156Conical tooth (HP:0000698)1.61600234
157Thyroid-stimulating hormone excess (HP:0002925)1.61181887
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.61032587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.26560646
2TNIK3.19721004
3PRPF4B2.63748361
4ACVR1B2.41303375
5TXK2.30023956
6INSRR2.24961748
7TLK12.20731374
8NTRK32.19951812
9MAP2K72.17391969
10PINK12.14738988
11ZAK2.14007565
12PNCK1.92242697
13AKT31.87312125
14IRAK41.85125586
15YES11.83549081
16MAPK131.81694095
17SGK21.81667948
18MAP4K21.77116688
19MAP3K141.73812347
20CDK31.72860647
21CLK11.71488357
22EIF2AK21.68127626
23MKNK21.64175517
24SIK31.59933985
25NUAK11.51332176
26NEK61.48586524
27GRK11.46100661
28BMPR21.43453752
29BRD41.43370988
30BMPR1B1.35517933
31SRPK11.35025397
32TRIM281.27578021
33DAPK21.23786286
34ADRBK11.19811806
35BLK1.18998399
36CAMKK21.18485598
37TGFBR11.18264531
38ERBB31.16690959
39EPHA41.16426088
40SGK4941.15156073
41SGK2231.15156073
42IRAK31.14564610
43TEC1.08258410
44DYRK21.05084918
45TNK21.04743448
46MUSK1.02118894
47PAK31.00457884
48WNK41.00259719
49MKNK11.00176724
50SGK30.99830725
51ADRBK20.97540291
52EPHA30.96872250
53NTRK20.96012601
54STK240.90771153
55TIE10.90166272
56PRKCG0.89964607
57NLK0.89354295
58STK160.88811091
59FRK0.87325428
60PIK3CA0.86495592
61PRKD20.85504697
62IRAK10.85439624
63SIK20.84781870
64MARK10.84312527
65FGFR20.83030885
66PKN10.81888555
67PRKCE0.77740029
68CSNK1G20.77630401
69GRK70.76245444
70CAMK1G0.75795192
71TAOK20.75085298
72BCR0.74767492
73IKBKE0.74642427
74SGK10.74392802
75MAP3K130.69880511
76CAMK1D0.68494611
77MAP2K40.68333637
78PLK20.67351927
79CDK80.67054153
80STK390.66721982
81PTK2B0.66142933
82RIPK40.65056542
83IRAK20.64365475
84FES0.64311951
85KIT0.61767985
86ERBB20.60136473
87PRKCQ0.60047762
88MAPK70.59021982
89CDK90.57875638
90WNK30.57794065
91OBSCN0.56926655
92FGR0.56594797
93IKBKB0.56166974
94JAK10.55990708
95CDK190.54965847
96MAP3K40.54264173
97CCNB10.54070408
98CAMK2A0.53803530
99WNK10.53134570
100RPS6KA50.52737889
101CAMK40.52058807
102PASK0.51929419
103CHUK0.51868873
104SYK0.51610032
105PLK40.51484370
106ITK0.50264276
107PRKG10.49630830
108VRK10.49096578
109CSNK1G10.49007603
110LYN0.48933554
111PRKCZ0.48804357
112ATR0.48659303
113CAMK10.48544938
114PRKACA0.47596087
115DYRK1A0.46660904
116RPS6KA40.46473381
117JAK30.46345844
118PIK3CG0.45609389
119HIPK20.44348734
120TYRO30.44206595
121DYRK30.44078881
122TAOK30.43205661
123FGFR30.42805553
124OXSR10.42713837
125CSNK1G30.41675406
126GRK50.41295485
127CAMK2B0.40598096
128STK110.40240009
129CSNK1A1L0.40140219
130HCK0.38532562
131RPS6KB10.38515569
132TRPM70.38264565
133MAPK150.38085927
134MAP3K120.37749224
135RPS6KA60.37614330
136BTK0.37547063
137CSNK1D0.37265319
138BCKDK0.36394282
139LCK0.35130378
140UHMK10.33154929
141PHKG10.33050106
142PHKG20.33050106
143MINK10.31857780
144CSNK1A10.31166881

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.81118885
2Linoleic acid metabolism_Homo sapiens_hsa005912.67627933
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50448458
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.15047765
5Phototransduction_Homo sapiens_hsa047442.13597090
6Fanconi anemia pathway_Homo sapiens_hsa034602.08318801
7Nitrogen metabolism_Homo sapiens_hsa009102.02475297
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91948179
9Morphine addiction_Homo sapiens_hsa050321.88312777
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78902870
11Taste transduction_Homo sapiens_hsa047421.77114693
12Butanoate metabolism_Homo sapiens_hsa006501.71267923
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63024061
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.62183136
15Selenocompound metabolism_Homo sapiens_hsa004501.61244486
16Primary immunodeficiency_Homo sapiens_hsa053401.54425318
17Serotonergic synapse_Homo sapiens_hsa047261.52403901
18Autoimmune thyroid disease_Homo sapiens_hsa053201.49973575
19Glutamatergic synapse_Homo sapiens_hsa047241.49264188
20Olfactory transduction_Homo sapiens_hsa047401.42942013
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42700585
22Circadian entrainment_Homo sapiens_hsa047131.38479066
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38133989
24Allograft rejection_Homo sapiens_hsa053301.32117966
25Dorso-ventral axis formation_Homo sapiens_hsa043201.31280947
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.30726775
27Cardiac muscle contraction_Homo sapiens_hsa042601.27425226
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26094399
29Non-homologous end-joining_Homo sapiens_hsa034501.25956908
30Graft-versus-host disease_Homo sapiens_hsa053321.25230199
31Oxidative phosphorylation_Homo sapiens_hsa001901.23045919
32GABAergic synapse_Homo sapiens_hsa047271.20038529
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19761841
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19332170
35Calcium signaling pathway_Homo sapiens_hsa040201.18596281
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17759655
37Tryptophan metabolism_Homo sapiens_hsa003801.17033660
38Sphingolipid metabolism_Homo sapiens_hsa006001.12418405
39Axon guidance_Homo sapiens_hsa043601.11906980
40Caffeine metabolism_Homo sapiens_hsa002321.10052227
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10023356
42ABC transporters_Homo sapiens_hsa020101.09248681
43Hematopoietic cell lineage_Homo sapiens_hsa046401.05963928
44Salivary secretion_Homo sapiens_hsa049701.05127641
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04705068
46Inositol phosphate metabolism_Homo sapiens_hsa005621.03003587
47Measles_Homo sapiens_hsa051621.02516420
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01820196
49Amphetamine addiction_Homo sapiens_hsa050311.01229598
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.00243319
51Homologous recombination_Homo sapiens_hsa034400.99759088
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97905412
53RNA degradation_Homo sapiens_hsa030180.96636605
54Long-term potentiation_Homo sapiens_hsa047200.96089458
55Cholinergic synapse_Homo sapiens_hsa047250.95129634
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94243823
57T cell receptor signaling pathway_Homo sapiens_hsa046600.94009154
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93652859
59Insulin secretion_Homo sapiens_hsa049110.93258471
60Parkinsons disease_Homo sapiens_hsa050120.91964274
61Wnt signaling pathway_Homo sapiens_hsa043100.91367630
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90855077
63Long-term depression_Homo sapiens_hsa047300.90474007
64Basal transcription factors_Homo sapiens_hsa030220.89658567
65Protein export_Homo sapiens_hsa030600.89628643
66cAMP signaling pathway_Homo sapiens_hsa040240.89611375
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89003022
68Chemokine signaling pathway_Homo sapiens_hsa040620.87607834
69Circadian rhythm_Homo sapiens_hsa047100.86266252
70Renin secretion_Homo sapiens_hsa049240.86162031
71African trypanosomiasis_Homo sapiens_hsa051430.84747881
72Chemical carcinogenesis_Homo sapiens_hsa052040.82946418
73Rheumatoid arthritis_Homo sapiens_hsa053230.82266338
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82085098
75Basal cell carcinoma_Homo sapiens_hsa052170.81944500
76ErbB signaling pathway_Homo sapiens_hsa040120.80321111
77Retinol metabolism_Homo sapiens_hsa008300.79754383
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79600642
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79273637
80Dopaminergic synapse_Homo sapiens_hsa047280.78277449
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78039895
82Alzheimers disease_Homo sapiens_hsa050100.77495948
83Asthma_Homo sapiens_hsa053100.76804078
84Cocaine addiction_Homo sapiens_hsa050300.75851251
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75715843
86Oxytocin signaling pathway_Homo sapiens_hsa049210.74387381
87Ovarian steroidogenesis_Homo sapiens_hsa049130.74312583
88MAPK signaling pathway_Homo sapiens_hsa040100.73551874
89Herpes simplex infection_Homo sapiens_hsa051680.73464124
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.72246629
91Ras signaling pathway_Homo sapiens_hsa040140.71451827
92Regulation of autophagy_Homo sapiens_hsa041400.70853816
93Type II diabetes mellitus_Homo sapiens_hsa049300.70787338
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70685164
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69911600
96Peroxisome_Homo sapiens_hsa041460.69351885
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68341443
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68176429
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67768376
100Ether lipid metabolism_Homo sapiens_hsa005650.67014429
101RNA polymerase_Homo sapiens_hsa030200.66875927
102Melanogenesis_Homo sapiens_hsa049160.66456051
103Melanoma_Homo sapiens_hsa052180.65968334
104Osteoclast differentiation_Homo sapiens_hsa043800.65801862
105TNF signaling pathway_Homo sapiens_hsa046680.64810916
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62902924
107Choline metabolism in cancer_Homo sapiens_hsa052310.62507250
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62198664
109B cell receptor signaling pathway_Homo sapiens_hsa046620.61973381
110Prostate cancer_Homo sapiens_hsa052150.61539853
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60933464
112Synaptic vesicle cycle_Homo sapiens_hsa047210.60576930
113Type I diabetes mellitus_Homo sapiens_hsa049400.59958819
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59957060
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59750853
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.58155793
117Arachidonic acid metabolism_Homo sapiens_hsa005900.56272173
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55927036
119Huntingtons disease_Homo sapiens_hsa050160.55447464
120Gastric acid secretion_Homo sapiens_hsa049710.54612642
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.54470551
122Collecting duct acid secretion_Homo sapiens_hsa049660.54169293
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53622338
124FoxO signaling pathway_Homo sapiens_hsa040680.53273820
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52294286
126GnRH signaling pathway_Homo sapiens_hsa049120.51052657
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50900642
128Endometrial cancer_Homo sapiens_hsa052130.50851134
129Malaria_Homo sapiens_hsa051440.49726171
130Propanoate metabolism_Homo sapiens_hsa006400.49534105
131Rap1 signaling pathway_Homo sapiens_hsa040150.49244466
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49117060
133Influenza A_Homo sapiens_hsa051640.48858557
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.48678025
135Leishmaniasis_Homo sapiens_hsa051400.48167395
136Hedgehog signaling pathway_Homo sapiens_hsa043400.47606258
137Hepatitis B_Homo sapiens_hsa051610.47382225
138Glycerolipid metabolism_Homo sapiens_hsa005610.46621746
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41250302
140Pancreatic secretion_Homo sapiens_hsa049720.40795238
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40669239
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37395666
143Histidine metabolism_Homo sapiens_hsa003400.34265685
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.33609582

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