SENP3-EIF4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.21277453
2negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.10008445
3mitotic cell cycle arrest (GO:0071850)4.05221964
4sleep (GO:0030431)3.88652734
5rRNA modification (GO:0000154)3.85604778
6rRNA methylation (GO:0031167)3.84468837
7negative regulation of DNA-templated transcription, elongation (GO:0032785)3.73690428
8DNA deamination (GO:0045006)3.63151727
9UV protection (GO:0009650)3.48718796
10response to gravity (GO:0009629)3.48690111
11positive regulation of defense response to virus by host (GO:0002230)3.48284378
12regulation of defense response to virus by host (GO:0050691)3.45739627
13response to muramyl dipeptide (GO:0032495)3.44702083
14positive regulation of prostaglandin secretion (GO:0032308)3.44420307
15DNA strand renaturation (GO:0000733)3.41255663
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.40304360
17purinergic nucleotide receptor signaling pathway (GO:0035590)3.39857456
18cellular response to ATP (GO:0071318)3.37371688
19negative regulation of cell killing (GO:0031342)3.35067771
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35067771
21cellular response to exogenous dsRNA (GO:0071360)3.30733369
22chaperone mediated protein folding requiring cofactor (GO:0051085)3.29240954
23GDP-mannose metabolic process (GO:0019673)3.25090994
24positive regulation of heat generation (GO:0031652)3.21369047
25mast cell activation involved in immune response (GO:0002279)3.16736288
26mast cell degranulation (GO:0043303)3.16736288
27cellular response to interleukin-15 (GO:0071350)3.09470420
28RNA destabilization (GO:0050779)3.08726794
29rRNA catabolic process (GO:0016075)3.08706875
30base-excision repair, AP site formation (GO:0006285)3.07150695
31mast cell activation (GO:0045576)3.06743646
32attachment of spindle microtubules to kinetochore (GO:0008608)3.04799731
33folic acid metabolic process (GO:0046655)3.01786005
34meiotic chromosome segregation (GO:0045132)2.97895327
35tRNA modification (GO:0006400)2.96180217
36regulation of prostaglandin secretion (GO:0032306)2.95234540
37regulation of germinal center formation (GO:0002634)2.93278393
38interferon-gamma production (GO:0032609)2.92434644
39pseudouridine synthesis (GO:0001522)2.92072165
40positive thymic T cell selection (GO:0045059)2.90998445
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88010933
42tolerance induction (GO:0002507)2.85800805
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83659059
44production of molecular mediator involved in inflammatory response (GO:0002532)2.83015686
45piRNA metabolic process (GO:0034587)2.80553196
46negative regulation of cell aging (GO:0090344)2.74064168
47tumor necrosis factor-mediated signaling pathway (GO:0033209)2.73471731
48cellular response to dsRNA (GO:0071359)2.69766602
49DNA replication checkpoint (GO:0000076)2.69725206
50ribosome assembly (GO:0042255)2.68763201
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67991202
52Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66658074
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.65849993
54termination of RNA polymerase III transcription (GO:0006386)2.65849993
55purine deoxyribonucleotide catabolic process (GO:0009155)2.64114344
56methionine biosynthetic process (GO:0009086)2.63171235
57adenosine metabolic process (GO:0046085)2.63034942
58iron-sulfur cluster assembly (GO:0016226)2.62852087
59metallo-sulfur cluster assembly (GO:0031163)2.62852087
60leukocyte degranulation (GO:0043299)2.62541087
61negative thymic T cell selection (GO:0045060)2.62532589
62negative regulation of innate immune response (GO:0045824)2.60346273
63regulation of skeletal muscle contraction (GO:0014819)2.59016926
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56807008
65positive regulation of T-helper 1 type immune response (GO:0002827)2.56013341
66regulation of T cell mediated cytotoxicity (GO:0001914)2.55771399
67preassembly of GPI anchor in ER membrane (GO:0016254)2.53761419
68mitochondrial RNA metabolic process (GO:0000959)2.53671884
69RNA methylation (GO:0001510)2.51967464
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50805062
71nucleotide transmembrane transport (GO:1901679)2.47838183
72positive regulation of T cell cytokine production (GO:0002726)2.47342262
73nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.46372053
74negative T cell selection (GO:0043383)2.44879298
75folic acid-containing compound biosynthetic process (GO:0009396)2.41648510
76DNA catabolic process, exonucleolytic (GO:0000738)2.40911710
77positive regulation of T cell mediated immunity (GO:0002711)2.40367743
78regulation of memory T cell differentiation (GO:0043380)2.40128363
79cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.39554142
80response to interleukin-15 (GO:0070672)2.38933808
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38789143
82regulation of B cell receptor signaling pathway (GO:0050855)2.37833927
83microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.37294728
84amino acid salvage (GO:0043102)2.36212550
85L-methionine salvage (GO:0071267)2.36212550
86L-methionine biosynthetic process (GO:0071265)2.36212550
87tRNA methylation (GO:0030488)2.35907321
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.35852308
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.35852308
90isotype switching (GO:0045190)2.35852308
91regulation of immunoglobulin secretion (GO:0051023)2.34778283
92RNA modification (GO:0009451)2.34476751
93positive regulation of osteoclast differentiation (GO:0045672)2.34130615
94B cell homeostasis (GO:0001782)2.33076973
95termination of RNA polymerase I transcription (GO:0006363)2.32333525
96peptidyl-arginine omega-N-methylation (GO:0035247)2.31679948
97nuclear envelope reassembly (GO:0031468)2.31175290
98mitotic nuclear envelope reassembly (GO:0007084)2.31175290
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.30452349
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.28187004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95474245
2ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66199263
3VDR_21846776_ChIP-Seq_THP-1_Human2.49143751
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47637281
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47599628
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.40331058
7XRN2_22483619_ChIP-Seq_HELA_Human2.39972621
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.30598566
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.22865324
10E2F7_22180533_ChIP-Seq_HELA_Human2.22083077
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19396296
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18116663
13MYC_22102868_ChIP-Seq_BL_Human2.17551371
14VDR_23849224_ChIP-Seq_CD4+_Human2.13425555
15CIITA_25753668_ChIP-Seq_RAJI_Human2.11101187
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.03865649
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02300731
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97693218
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97513385
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94218798
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93197611
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91960367
23MAF_26560356_Chip-Seq_TH1_Human1.88156345
24MAF_26560356_Chip-Seq_TH2_Human1.85302608
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.85210027
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80500682
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.77218560
28FOXP3_21729870_ChIP-Seq_TREG_Human1.76800196
29DCP1A_22483619_ChIP-Seq_HELA_Human1.72509586
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72100667
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69998476
32GABP_19822575_ChIP-Seq_HepG2_Human1.68020220
33UTX_26944678_Chip-Seq_JUKART_Human1.67647513
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65437154
35P68_20966046_ChIP-Seq_HELA_Human1.64207333
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63329426
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60888354
38BCL6_27268052_Chip-Seq_Bcells_Human1.59819757
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58420433
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56952848
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.56035843
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.52297424
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51408526
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50194934
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49051424
46BCOR_27268052_Chip-Seq_Bcells_Human1.47457518
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46678833
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45612088
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44403559
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43971447
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.43968119
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43322484
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42530915
54VDR_24763502_ChIP-Seq_THP-1_Human1.42390757
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42365733
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.42168420
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.40545166
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40400175
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.40250190
60SPI1_23547873_ChIP-Seq_NB4_Human1.38744422
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38240656
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37955723
63TTF2_22483619_ChIP-Seq_HELA_Human1.37618781
64E2F1_20622854_ChIP-Seq_HELA_Human1.37179090
65MYB_26560356_Chip-Seq_TH2_Human1.36402766
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34429053
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.33711565
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28312146
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27431597
70KDM5A_27292631_Chip-Seq_BREAST_Human1.27312536
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24979584
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24633784
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23666357
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22563883
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21169288
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20534722
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19726714
78MYB_26560356_Chip-Seq_TH1_Human1.19652495
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18955204
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18870197
81PHF8_20622854_ChIP-Seq_HELA_Human1.18840915
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18195313
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.17513090
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.17366995
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17141929
86LXR_22292898_ChIP-Seq_THP-1_Human1.16473706
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13791230
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13564367
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13291881
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12810638
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12052796
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.10912625
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09161147
94ETS1_21867929_ChIP-Seq_TH2_Mouse1.09011869
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08196658
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07930721
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.07053852
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.06977544
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05820522
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.05407391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.34379592
2MP0001986_abnormal_taste_sensitivity2.93442500
3MP0000685_abnormal_immune_system2.90378597
4MP0003806_abnormal_nucleotide_metabolis2.81020121
5MP0001835_abnormal_antigen_presentation2.75746743
6MP0005174_abnormal_tail_pigmentation2.65605467
7MP0003763_abnormal_thymus_physiology2.62707132
8MP0005671_abnormal_response_to2.59942611
9MP0002148_abnormal_hypersensitivity_rea2.33915574
10MP0005000_abnormal_immune_tolerance2.32214037
11MP0010094_abnormal_chromosome_stability2.30828756
12MP0002009_preneoplasia2.25571072
13MP0008875_abnormal_xenobiotic_pharmacok2.17783065
14MP0003111_abnormal_nucleus_morphology2.15354063
15MP0002723_abnormal_immune_serum2.15264379
16MP0005171_absent_coat_pigmentation2.11032759
17MP0003724_increased_susceptibility_to2.10382739
18MP0001800_abnormal_humoral_immune2.01713375
19MP0002166_altered_tumor_susceptibility1.97735512
20MP0004947_skin_inflammation1.96625444
21MP0003786_premature_aging1.95420517
22MP0002452_abnormal_antigen_presenting1.94820956
23MP0001819_abnormal_immune_cell1.83340945
24MP0002006_tumorigenesis1.81986472
25MP0002420_abnormal_adaptive_immunity1.81346127
26MP0002398_abnormal_bone_marrow1.81278202
27MP0008058_abnormal_DNA_repair1.80787557
28MP0003828_pulmonary_edema1.78528428
29MP0003693_abnormal_embryo_hatching1.77564542
30MP0002405_respiratory_system_inflammati1.70725252
31MP0005083_abnormal_biliary_tract1.69922221
32MP0001661_extended_life_span1.66620354
33MP0009333_abnormal_splenocyte_physiolog1.64931958
34MP0002722_abnormal_immune_system1.60678559
35MP0000703_abnormal_thymus_morphology1.59726282
36MP0002019_abnormal_tumor_incidence1.57942535
37MP0009785_altered_susceptibility_to1.57006500
38MP0000716_abnormal_immune_system1.55000063
39MP0000689_abnormal_spleen_morphology1.54456120
40MP0001873_stomach_inflammation1.53979544
41MP0002419_abnormal_innate_immunity1.53033654
42MP0005058_abnormal_lysosome_morphology1.49815909
43MP0002429_abnormal_blood_cell1.49805966
44MP0003077_abnormal_cell_cycle1.49392670
45MP0001853_heart_inflammation1.45411815
46MP0005025_abnormal_response_to1.44482644
47MP0002933_joint_inflammation1.43944996
48MP0004957_abnormal_blastocyst_morpholog1.41987870
49MP0001533_abnormal_skeleton_physiology1.41753430
50MP0009764_decreased_sensitivity_to1.35023603
51MP0001790_abnormal_immune_system1.34649101
52MP0005387_immune_system_phenotype1.34649101
53MP0001919_abnormal_reproductive_system1.32313780
54MP0009840_abnormal_foam_cell1.32287065
55MP0003191_abnormal_cellular_cholesterol1.30132050
56MP0000858_altered_metastatic_potential1.29503283
57MP0002877_abnormal_melanocyte_morpholog1.26395750
58MP0003950_abnormal_plasma_membrane1.24175831
59MP0000015_abnormal_ear_pigmentation1.24160934
60MP0009278_abnormal_bone_marrow1.21220105
61MP0001845_abnormal_inflammatory_respons1.21028576
62MP0010155_abnormal_intestine_physiology1.16129856
63MP0008007_abnormal_cellular_replicative1.14629063
64MP0005464_abnormal_platelet_physiology1.13288557
65MP0000465_gastrointestinal_hemorrhage1.01104172
66MP0008469_abnormal_protein_level1.00621814
67MP0004147_increased_porphyrin_level0.98901302
68MP0001765_abnormal_ion_homeostasis0.98634998
69MP0000013_abnormal_adipose_tissue0.97646634
70MP0000358_abnormal_cell_content/0.93569352
71MP0005084_abnormal_gallbladder_morpholo0.93040782
72MP0003656_abnormal_erythrocyte_physiolo0.91968472
73MP0006072_abnormal_retinal_apoptosis0.91643889
74MP0002160_abnormal_reproductive_system0.91628217
75MP0005410_abnormal_fertilization0.89221307
76MP0005389_reproductive_system_phenotype0.87433370
77MP0003718_maternal_effect0.87203044
78MP0002876_abnormal_thyroid_physiology0.83810839
79MP0005332_abnormal_amino_acid0.82569616
80MP0009931_abnormal_skin_appearance0.82191783
81MP0005423_abnormal_somatic_nervous0.79913998
82MP0005075_abnormal_melanosome_morpholog0.78628981
83MP0000490_abnormal_crypts_of0.77920367
84MP0005076_abnormal_cell_differentiation0.76619148
85MP0003172_abnormal_lysosome_physiology0.75357374
86MP0001968_abnormal_touch/_nociception0.73196926
87MP0001216_abnormal_epidermal_layer0.72777846
88MP0001243_abnormal_dermal_layer0.71125043
89MP0004782_abnormal_surfactant_physiolog0.71080774
90MP0005501_abnormal_skin_physiology0.69859155
91MP0008057_abnormal_DNA_replication0.69597752
92MP0005330_cardiomyopathy0.67350933
93MP0000313_abnormal_cell_death0.67347702
94MP0002736_abnormal_nociception_after0.66326992
95MP0004043_abnormal_pH_regulation0.65948154
96MP0000747_muscle_weakness0.64293017
97MP0004808_abnormal_hematopoietic_stem0.63299690
98MP0008775_abnormal_heart_ventricle0.60672021
99MP0003448_altered_tumor_morphology0.60472660
100MP0002998_abnormal_bone_remodeling0.57836399

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)4.52617636
2Attenuation of retinal blood vessels (HP:0007843)4.09020889
3IgG deficiency (HP:0004315)3.88832279
4Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.62145073
5Facial diplegia (HP:0001349)3.59649558
6Poikiloderma (HP:0001029)3.58761255
7Squamous cell carcinoma (HP:0002860)3.52740101
8Dyschromatopsia (HP:0007641)3.47303258
9Rectovaginal fistula (HP:0000143)3.40552144
10Rectal fistula (HP:0100590)3.40552144
11Vaginal fistula (HP:0004320)3.12887687
12Intestinal fistula (HP:0100819)3.12067425
13Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97268138
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91966502
15Absent thumb (HP:0009777)2.88973767
16Pustule (HP:0200039)2.81491939
17Increased hepatocellular lipid droplets (HP:0006565)2.73183218
18Progressive muscle weakness (HP:0003323)2.68951179
19Elevated erythrocyte sedimentation rate (HP:0003565)2.67592274
20Abnormality of the pons (HP:0007361)2.66964808
21Mesangial abnormality (HP:0001966)2.64450909
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.63816712
23Joint stiffness (HP:0001387)2.61638323
24Hypoplasia of the pons (HP:0012110)2.61475004
25Increased intramyocellular lipid droplets (HP:0012240)2.61436863
26Lipid accumulation in hepatocytes (HP:0006561)2.58389944
27Congenital stationary night blindness (HP:0007642)2.57567285
28Renal Fanconi syndrome (HP:0001994)2.52794552
29Abnormal protein glycosylation (HP:0012346)2.52614384
30Abnormal glycosylation (HP:0012345)2.52614384
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52614384
32Abnormal protein N-linked glycosylation (HP:0012347)2.52614384
33Severe combined immunodeficiency (HP:0004430)2.50228043
34Type I transferrin isoform profile (HP:0003642)2.46152344
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46092138
36Abnormality of polysaccharide metabolism (HP:0011012)2.46092138
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46092138
38Abnormality of T cell physiology (HP:0011840)2.44277554
39Chronic mucocutaneous candidiasis (HP:0002728)2.43874585
40Recurrent cutaneous fungal infections (HP:0011370)2.43874585
41Type 2 muscle fiber atrophy (HP:0003554)2.41908941
42Premature graying of hair (HP:0002216)2.40017870
43Muscle fiber atrophy (HP:0100295)2.38162598
44Increased muscle lipid content (HP:0009058)2.35557345
45Rib fusion (HP:0000902)2.32602825
46Abnormality of eosinophils (HP:0001879)2.31878109
47Abnormal albumin level (HP:0012116)2.29117058
48Hypoalbuminemia (HP:0003073)2.29117058
49Abnormality of T cells (HP:0002843)2.28700582
50Mucopolysacchariduria (HP:0008155)2.28676566
51Urinary glycosaminoglycan excretion (HP:0003541)2.28676566
52Abnormality of placental membranes (HP:0011409)2.27667658
53Amniotic constriction ring (HP:0009775)2.27667658
54Abnormality of the intrinsic pathway (HP:0010989)2.22489102
55Abnormality of DNA repair (HP:0003254)2.19699688
56Dysostosis multiplex (HP:0000943)2.19549140
57Entropion (HP:0000621)2.19175421
58Panhypogammaglobulinemia (HP:0003139)2.17557141
59Aplasia/Hypoplasia involving the musculature (HP:0001460)2.14875605
60Aplasia of the musculature (HP:0100854)2.13892244
61Ragged-red muscle fibers (HP:0003200)2.13725017
62Abnormality of the prostate (HP:0008775)2.13538545
63Hemorrhage of the eye (HP:0011885)2.13157695
64Basal cell carcinoma (HP:0002671)2.13072260
65Patellar aplasia (HP:0006443)2.10640460
66Fatigue (HP:0012378)2.09978037
67Prostate neoplasm (HP:0100787)2.09733354
68T lymphocytopenia (HP:0005403)2.07788191
69Aplasia/Hypoplasia of the patella (HP:0006498)2.07284412
70Increased serum lactate (HP:0002151)2.06320349
71Cheilitis (HP:0100825)2.04548121
72Combined immunodeficiency (HP:0005387)2.04296888
73Abnormality of T cell number (HP:0011839)2.01730578
74Decreased central vision (HP:0007663)1.96842002
75Progressive microcephaly (HP:0000253)1.96752610
76Persistence of primary teeth (HP:0006335)1.96730682
77Choroideremia (HP:0001139)1.94108543
78IgA deficiency (HP:0002720)1.93292294
79Duplicated collecting system (HP:0000081)1.92545497
80Pancytopenia (HP:0001876)1.90982332
81Cerebellar dysplasia (HP:0007033)1.89881205
82Gastrointestinal infarctions (HP:0005244)1.89635607
83Anorexia (HP:0002039)1.88768030
84Recurrent fungal infections (HP:0002841)1.87010186
85Myositis (HP:0100614)1.86823338
86Reduced antithrombin III activity (HP:0001976)1.85443731
87Exertional dyspnea (HP:0002875)1.84875819
88Conical tooth (HP:0000698)1.84556822
89Opisthotonus (HP:0002179)1.83009247
90Increased IgM level (HP:0003496)1.82386901
91Popliteal pterygium (HP:0009756)1.82337317
92Joint hemorrhage (HP:0005261)1.82163567
93Hypergonadotropic hypogonadism (HP:0000815)1.81724826
94Stomatitis (HP:0010280)1.79023118
95Bony spicule pigmentary retinopathy (HP:0007737)1.77956720
96Stomach cancer (HP:0012126)1.77116429
97Granulocytopenia (HP:0001913)1.76333759
98Clumsiness (HP:0002312)1.76178675
99Abnormal spermatogenesis (HP:0008669)1.75913460
100Epiphyseal stippling (HP:0010655)1.74931220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.30512469
2TESK24.26351961
3TAOK33.53191231
4TXK3.37479669
5ZAK3.18535765
6VRK23.01810099
7MAP3K142.87499173
8MUSK2.84121452
9GRK62.66671289
10MAP2K22.66040042
11IRAK32.51859571
12NEK12.41297874
13TBK12.22097541
14MAPK152.18990887
15STK161.91997177
16IKBKB1.88577477
17MAPKAPK31.74580704
18MAP4K11.64114142
19MAP4K21.59248432
20BCKDK1.57879455
21WNK41.52554727
22NUAK11.51214694
23IKBKE1.48260619
24BUB11.45648448
25NME21.43532228
26KDR1.39266042
27CDK81.30821518
28CCNB11.23312080
29CDK41.20837569
30KIT1.18775796
31SRPK11.16762288
32VRK11.10993129
33ZAP701.08999825
34STK101.08757183
35CSF1R1.07289032
36PDK21.03843641
37MAP2K30.91845603
38EIF2AK20.91702358
39MAPK110.91518974
40SIK20.91216098
41FES0.88903814
42DAPK10.85422345
43NEK20.80871842
44JAK30.80176998
45EPHA20.78390508
46AURKA0.77748373
47MST40.76484969
48SCYL20.74703732
49ADRBK20.74560121
50CHEK20.72726579
51PIM20.72227831
52EEF2K0.71959643
53SYK0.71825450
54MATK0.71486196
55RPS6KA50.70096965
56ITK0.69811318
57CHUK0.68727876
58ATR0.66501529
59TEC0.64643798
60RPS6KA20.62592148
61BLK0.61956949
62SMG10.60303149
63FLT30.59567711
64MAP2K60.57959292
65EIF2AK30.56577588
66LCK0.56443526
67PIM10.55927705
68BTK0.53760057
69JAK10.52641410
70LYN0.51626688
71LIMK10.48675886
72TRPM70.45423904
73ERN10.45190636
74MAPKAPK20.43470353
75RPS6KB20.43401117
76OXSR10.42035206
77MAP2K10.41437427
78AURKB0.41335070
79MAP3K130.40788703
80TRIB30.39138137
81BMPR20.38551590
82MAPKAPK50.37409526
83PRKCI0.36712920
84GRK10.35239861
85ADRBK10.32625351
86BRD40.32525757
87CDK70.32210651
88HCK0.32042448
89PRKD20.31620006
90CDK60.30667224
91MST1R0.30358178
92ABL10.29769436
93PBK0.29743262
94PLK10.29648101
95RPS6KA10.29551361
96PRKCQ0.28926573
97IRAK40.26440962
98PHKG20.25945361
99PHKG10.25945361
100PDPK10.25508467

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.61518093
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81060846
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71415708
4Sulfur relay system_Homo sapiens_hsa041222.67744795
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.64058005
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.63843910
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51264333
8RNA polymerase_Homo sapiens_hsa030202.47648583
9DNA replication_Homo sapiens_hsa030302.32200821
10Primary immunodeficiency_Homo sapiens_hsa053402.26746849
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.25213279
12Asthma_Homo sapiens_hsa053102.16047658
13Base excision repair_Homo sapiens_hsa034102.15094455
14Fanconi anemia pathway_Homo sapiens_hsa034602.09916705
15Graft-versus-host disease_Homo sapiens_hsa053322.02926452
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.98863281
17Allograft rejection_Homo sapiens_hsa053301.97968326
18Homologous recombination_Homo sapiens_hsa034401.90393468
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84644044
20Proteasome_Homo sapiens_hsa030501.84249065
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81448021
22One carbon pool by folate_Homo sapiens_hsa006701.77361237
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74388426
24Autoimmune thyroid disease_Homo sapiens_hsa053201.74269186
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73686501
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60448007
27Pyrimidine metabolism_Homo sapiens_hsa002401.58919748
28Antigen processing and presentation_Homo sapiens_hsa046121.53837417
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53625317
30Basal transcription factors_Homo sapiens_hsa030221.45980118
31Herpes simplex infection_Homo sapiens_hsa051681.43886207
32Other glycan degradation_Homo sapiens_hsa005111.42774711
33Sulfur metabolism_Homo sapiens_hsa009201.37550517
34RNA degradation_Homo sapiens_hsa030181.36611703
35Nucleotide excision repair_Homo sapiens_hsa034201.36349066
36Spliceosome_Homo sapiens_hsa030401.30243250
37RNA transport_Homo sapiens_hsa030131.29130191
38Mismatch repair_Homo sapiens_hsa034301.28582468
39Systemic lupus erythematosus_Homo sapiens_hsa053221.27633271
40Type I diabetes mellitus_Homo sapiens_hsa049401.24310077
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21992648
42Leishmaniasis_Homo sapiens_hsa051401.17658678
43Hematopoietic cell lineage_Homo sapiens_hsa046401.13586902
44Non-homologous end-joining_Homo sapiens_hsa034501.10855677
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03695507
46Rheumatoid arthritis_Homo sapiens_hsa053231.03389668
47Epstein-Barr virus infection_Homo sapiens_hsa051691.03272488
48Viral myocarditis_Homo sapiens_hsa054160.96331314
49Apoptosis_Homo sapiens_hsa042100.93401768
50Purine metabolism_Homo sapiens_hsa002300.87448928
51Measles_Homo sapiens_hsa051620.87300357
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86028261
53Legionellosis_Homo sapiens_hsa051340.84732004
54Lysosome_Homo sapiens_hsa041420.84235909
55TNF signaling pathway_Homo sapiens_hsa046680.82464616
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80456023
57T cell receptor signaling pathway_Homo sapiens_hsa046600.76334118
58B cell receptor signaling pathway_Homo sapiens_hsa046620.75315625
59Influenza A_Homo sapiens_hsa051640.72760645
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72031523
61Viral carcinogenesis_Homo sapiens_hsa052030.71606141
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69893551
63Fructose and mannose metabolism_Homo sapiens_hsa000510.68961795
64Selenocompound metabolism_Homo sapiens_hsa004500.68873268
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.67628529
66Osteoclast differentiation_Homo sapiens_hsa043800.67363215
67HTLV-I infection_Homo sapiens_hsa051660.67268689
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66577108
69Sphingolipid metabolism_Homo sapiens_hsa006000.65489944
70Toxoplasmosis_Homo sapiens_hsa051450.65452668
71Shigellosis_Homo sapiens_hsa051310.65201339
72Cell cycle_Homo sapiens_hsa041100.62013339
73p53 signaling pathway_Homo sapiens_hsa041150.60232749
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58980318
75N-Glycan biosynthesis_Homo sapiens_hsa005100.57850673
76Tuberculosis_Homo sapiens_hsa051520.53548278
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49731915
78Hepatitis B_Homo sapiens_hsa051610.43023772
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42304407
80Circadian rhythm_Homo sapiens_hsa047100.39419806
81Biosynthesis of amino acids_Homo sapiens_hsa012300.38884928
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.38862193
83Phototransduction_Homo sapiens_hsa047440.35594530
84Hepatitis C_Homo sapiens_hsa051600.35395154
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34678524
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.34320359
87Vitamin digestion and absorption_Homo sapiens_hsa049770.32456505
88Regulation of autophagy_Homo sapiens_hsa041400.31897559
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29362413
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29284765
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29009209
92Metabolic pathways_Homo sapiens_hsa011000.25049566
93Bladder cancer_Homo sapiens_hsa052190.22851922
94Pertussis_Homo sapiens_hsa051330.22245565
95Staphylococcus aureus infection_Homo sapiens_hsa051500.20515275
96Endocytosis_Homo sapiens_hsa041440.20111325
97Alcoholism_Homo sapiens_hsa050340.19670174
98Nitrogen metabolism_Homo sapiens_hsa009100.17223345
99Arachidonic acid metabolism_Homo sapiens_hsa005900.17086715
100Ether lipid metabolism_Homo sapiens_hsa005650.15868896

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