SENP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.38970697
2regulation of posttranscriptional gene silencing (GO:0060147)5.29195537
3regulation of gene silencing by miRNA (GO:0060964)5.29195537
4regulation of gene silencing by RNA (GO:0060966)5.29195537
5nuclear pore complex assembly (GO:0051292)5.11518043
6protein localization to kinetochore (GO:0034501)4.90277295
7mitotic nuclear envelope disassembly (GO:0007077)4.55027276
8DNA replication-dependent nucleosome assembly (GO:0006335)4.48440223
9DNA replication-dependent nucleosome organization (GO:0034723)4.48440223
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.36351630
11pre-miRNA processing (GO:0031054)4.35717642
12DNA unwinding involved in DNA replication (GO:0006268)4.35176438
13heterochromatin organization (GO:0070828)4.31427507
14folic acid-containing compound biosynthetic process (GO:0009396)4.30155645
15nuclear envelope disassembly (GO:0051081)4.30046581
16membrane disassembly (GO:0030397)4.30046581
17mitotic metaphase plate congression (GO:0007080)4.20590514
18protein localization to endosome (GO:0036010)4.20143080
19IMP biosynthetic process (GO:0006188)4.14105681
20nucleobase biosynthetic process (GO:0046112)4.12140893
21Golgi transport vesicle coating (GO:0048200)4.11948792
22COPI coating of Golgi vesicle (GO:0048205)4.11948792
23DNA replication initiation (GO:0006270)4.09385881
24formation of translation preinitiation complex (GO:0001731)4.04648438
25ribosome assembly (GO:0042255)4.02764604
26protein localization to chromosome, centromeric region (GO:0071459)3.99856389
27regulation of translational fidelity (GO:0006450)3.98320266
28regulation of translational termination (GO:0006449)3.98179364
29negative regulation of histone methylation (GO:0031061)3.92688467
30pore complex assembly (GO:0046931)3.82379285
31regulation of early endosome to late endosome transport (GO:2000641)3.79415280
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77881459
33adherens junction assembly (GO:0034333)3.77256378
34mitotic sister chromatid segregation (GO:0000070)3.75067251
35regulation of histone H3-K9 methylation (GO:0051570)3.73363267
36purine nucleobase biosynthetic process (GO:0009113)3.73107966
37apoptotic process involved in morphogenesis (GO:0060561)3.71827859
38proline biosynthetic process (GO:0006561)3.71065793
39regulation of helicase activity (GO:0051095)3.68373240
40positive regulation of chromosome segregation (GO:0051984)3.67054016
41ribosome biogenesis (GO:0042254)3.66042043
42protein K6-linked ubiquitination (GO:0085020)3.63449454
43focal adhesion assembly (GO:0048041)3.63126500
44cell-substrate adherens junction assembly (GO:0007045)3.63126500
45regulation of spindle organization (GO:0090224)3.60088882
46DNA geometric change (GO:0032392)3.56087121
47DNA duplex unwinding (GO:0032508)3.55878255
48IMP metabolic process (GO:0046040)3.54115033
49cellular protein complex localization (GO:0034629)3.52985917
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52618420
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.52618420
52metaphase plate congression (GO:0051310)3.52566256
53DNA replication checkpoint (GO:0000076)3.51601917
54positive regulation of SMAD protein import into nucleus (GO:0060391)3.50944235
55protein complex localization (GO:0031503)3.49295073
56sister chromatid segregation (GO:0000819)3.48913751
57peptidyl-arginine omega-N-methylation (GO:0035247)3.47181277
58DNA strand elongation involved in DNA replication (GO:0006271)3.44086800
59planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42490284
60histone H2A monoubiquitination (GO:0035518)3.42184829
61dosage compensation (GO:0007549)3.40027861
62chromatin assembly (GO:0031497)3.39974149
63mitotic chromosome condensation (GO:0007076)3.39849919
64histone arginine methylation (GO:0034969)3.39362807
65nuclear envelope organization (GO:0006998)3.38612626
66paraxial mesoderm development (GO:0048339)3.33524643
67regulation of mitotic spindle organization (GO:0060236)3.30852252
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.29486605
69positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.28325621
70regulation of sister chromatid cohesion (GO:0007063)3.28070961
71DNA strand elongation (GO:0022616)3.25128584
72determination of adult lifespan (GO:0008340)3.24981894
73maturation of SSU-rRNA (GO:0030490)3.22317449
74activation of Rac GTPase activity (GO:0032863)3.21389067
75protein retention in ER lumen (GO:0006621)3.20090078
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19510868
77regulation of gene silencing (GO:0060968)3.18353938
78histone H4-K12 acetylation (GO:0043983)3.17482243
79maternal placenta development (GO:0001893)3.15659518
80mRNA stabilization (GO:0048255)3.15300112
81RNA stabilization (GO:0043489)3.15300112
82regulation of NFAT protein import into nucleus (GO:0051532)3.15225108
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.13701551
84cell-substrate junction assembly (GO:0007044)3.12865572
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12863643
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11470742
87negative regulation of cell size (GO:0045792)3.10220330
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09685850
89establishment of apical/basal cell polarity (GO:0035089)3.09089432
903-UTR-mediated mRNA stabilization (GO:0070935)3.08431799
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07600166
92regulation of glucose import in response to insulin stimulus (GO:2001273)3.07209578
93regulation of chromosome segregation (GO:0051983)3.07154864
94regulation of telomere maintenance via telomerase (GO:0032210)3.06832687
95mitotic sister chromatid cohesion (GO:0007064)3.06061597
96negative regulation of erythrocyte differentiation (GO:0045647)3.06015892
97peptidyl-arginine methylation (GO:0018216)3.06009900
98peptidyl-arginine N-methylation (GO:0035246)3.06009900
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04942204
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04942204
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.04942204
102regulation of centrosome cycle (GO:0046605)3.04094677
103establishment of chromosome localization (GO:0051303)3.02357213
104ribonucleoprotein complex biogenesis (GO:0022613)3.00927193
105pentose-phosphate shunt (GO:0006098)3.00717153
106regulation of hippo signaling (GO:0035330)2.99644835
107regulation of RNA export from nucleus (GO:0046831)2.98912483
108spindle assembly involved in mitosis (GO:0090307)2.98361503
109protein localization to chromosome (GO:0034502)2.98163211
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.98139163
111mRNA transport (GO:0051028)2.98020377
112regulation of SMAD protein import into nucleus (GO:0060390)2.97017562
113chromatin assembly or disassembly (GO:0006333)2.96443557
114protein export from nucleus (GO:0006611)2.95116317
115negative regulation of chromosome segregation (GO:0051985)2.92442618
116mitotic G1 DNA damage checkpoint (GO:0031571)2.91944501
117chaperone-mediated protein complex assembly (GO:0051131)2.88925584
118folic acid metabolic process (GO:0046655)2.88819264
119attachment of spindle microtubules to kinetochore (GO:0008608)2.87821431
120microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.87279661
121embryonic process involved in female pregnancy (GO:0060136)2.85409994
122regulation of nucleobase-containing compound transport (GO:0032239)2.85397996
123telomere maintenance via semi-conservative replication (GO:0032201)2.83451207
124trophectodermal cell differentiation (GO:0001829)2.82761183
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.82555054
126anterior/posterior axis specification, embryo (GO:0008595)2.81072282
127DNA conformation change (GO:0071103)2.80720428
128spindle checkpoint (GO:0031577)2.79487298
129mitotic spindle checkpoint (GO:0071174)2.78050438
130nucleosome disassembly (GO:0006337)2.78027041
131protein-DNA complex disassembly (GO:0032986)2.78027041
132chromatin remodeling at centromere (GO:0031055)2.76972434
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76519060
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.75547911
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75547911
136negative regulation of sister chromatid segregation (GO:0033046)2.75547911
137pinocytosis (GO:0006907)2.72368930
138nucleobase-containing small molecule interconversion (GO:0015949)2.69517657
139ribosomal small subunit biogenesis (GO:0042274)2.68907097
140regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.68900140
141positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.68900140
142barbed-end actin filament capping (GO:0051016)2.67586460
143regulation of chromatin binding (GO:0035561)2.65340411
144negative regulation of fatty acid transport (GO:2000192)2.63045395
145stress fiber assembly (GO:0043149)2.61515430
146basement membrane organization (GO:0071711)2.61196210
147cellular response to epidermal growth factor stimulus (GO:0071364)2.61063200
148protein localization to microtubule (GO:0035372)2.58952958
149epithelial cell-cell adhesion (GO:0090136)2.57884138
150lymph vessel development (GO:0001945)2.57427295
151regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.56811253
152intracellular estrogen receptor signaling pathway (GO:0030520)2.55588782
153rRNA transcription (GO:0009303)2.53928675
154G1 DNA damage checkpoint (GO:0044783)2.51768439
155regulation of glucocorticoid metabolic process (GO:0031943)2.50890335
156NADPH regeneration (GO:0006740)2.50446028
157protein maturation by protein folding (GO:0022417)2.50420488
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50340532
159cellular hyperosmotic response (GO:0071474)2.49963665
160glucose catabolic process (GO:0006007)2.47130084
161positive regulation of nuclease activity (GO:0032075)2.46830566
162epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43818229
163glucocorticoid receptor signaling pathway (GO:0042921)2.40461108
164modulation by symbiont of host cellular process (GO:0044068)2.39151023
165chromosome condensation (GO:0030261)2.38768538
166positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38505407
167negative regulation of striated muscle cell differentiation (GO:0051154)2.36138190
168response to laminar fluid shear stress (GO:0034616)2.32677627
169cortical actin cytoskeleton organization (GO:0030866)2.32169308
170hemidesmosome assembly (GO:0031581)2.31911219
171apoptotic process involved in development (GO:1902742)2.31503804
172nuclear envelope reassembly (GO:0031468)2.30457241
173mitotic nuclear envelope reassembly (GO:0007084)2.30457241
174mitotic G1/S transition checkpoint (GO:0044819)2.29858507
175vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.29063761
176regulation of histone H3-K27 methylation (GO:0061085)2.28470885
177peptidyl-lysine dimethylation (GO:0018027)2.28216410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22683619
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46938374
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.88219569
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22973855
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17602314
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95555096
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.87262870
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69555583
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.64145756
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56972544
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54335179
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54335179
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54335179
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.50231969
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.30098841
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29787025
17LXR_22292898_ChIP-Seq_THP-1_Human2.27222302
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22635071
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20093962
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15902657
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12980707
22MYC_22102868_ChIP-Seq_BL_Human2.12475161
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11267829
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06970594
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02845536
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01566060
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00525184
28RACK7_27058665_Chip-Seq_MCF-7_Human1.99997539
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97863195
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97268715
31* XRN2_22483619_ChIP-Seq_HELA_Human1.93153030
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92457638
33AR_21909140_ChIP-Seq_LNCAP_Human1.89735731
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.88824943
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86314146
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86007683
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84503446
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82847745
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82580940
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82464066
41TCF7_22412390_ChIP-Seq_EML_Mouse1.81267407
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80425409
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.80326448
44KDM2B_26808549_Chip-Seq_DND41_Human1.77453301
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.74407476
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70111631
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65369857
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64909277
49CLOCK_20551151_ChIP-Seq_293T_Human1.62188790
50KDM2B_26808549_Chip-Seq_K562_Human1.61576522
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61428191
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61385668
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58510497
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.57649332
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57278386
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56462526
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54529926
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53522966
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53504032
60* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52147475
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51908787
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51718565
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51367288
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50393759
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48164961
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47845939
67KDM5A_27292631_Chip-Seq_BREAST_Human1.45818356
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45714753
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45182157
70ZNF263_19887448_ChIP-Seq_K562_Human1.44738329
71* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43924528
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43299505
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41484297
74* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40172332
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39784028
76CIITA_25753668_ChIP-Seq_RAJI_Human1.37007816
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.34802553
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.33994159
79VDR_23849224_ChIP-Seq_CD4+_Human1.33583337
80* TTF2_22483619_ChIP-Seq_HELA_Human1.33093452
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32490099
82DCP1A_22483619_ChIP-Seq_HELA_Human1.31684952
83GABP_19822575_ChIP-Seq_HepG2_Human1.31240403
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30641220
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27728451
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26975864
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26541484
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26537581
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.25631586
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25239274
91TFEB_21752829_ChIP-Seq_HELA_Human1.24902151
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24648681
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24145001
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22802224
95MAF_26560356_Chip-Seq_TH1_Human1.22405017
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22161884
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22146001
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21913726
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21725182
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21720097
101P68_20966046_ChIP-Seq_HELA_Human1.21575664
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21044804
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20693944
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20276343
105FOXP3_21729870_ChIP-Seq_TREG_Human1.19479772
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.16773687
107* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16633928
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16040472
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.15865898
110* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15722446
111CREB1_26743006_Chip-Seq_LNCaP_Human1.14871890
112NCOR1_26117541_ChIP-Seq_K562_Human1.14503757
113SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14189511
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14068591
115POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13085056
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12633617
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.12544186
118VDR_24763502_ChIP-Seq_THP-1_Human1.12525330
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11838619
120OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11573653
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09517692
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09383238
123TP53_22127205_ChIP-Seq_IMR90_Human1.08450286
124MAF_26560356_Chip-Seq_TH2_Human1.06913305
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06690193
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06491131
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.06402315
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05195361
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03813899
130E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03260055
131SMC4_20622854_ChIP-Seq_HELA_Human1.02646926
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02531169
133NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01522098
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01395286
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01093860
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00834018
137GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00720276
138VDR_21846776_ChIP-Seq_THP-1_Human1.00649768
139POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00291218
140* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99666081
141RUNX1_22412390_ChIP-Seq_EML_Mouse0.99411346
142* YY1_21170310_ChIP-Seq_MESCs_Mouse0.99227348
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99007894
144* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98557148
145UTX_26944678_Chip-Seq_JUKART_Human0.98386152
146NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96342726
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.96302263
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95751619
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93702171
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91209259
151ATF3_27146783_Chip-Seq_COLON_Human0.90586077
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88889762
153* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88828800
154* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88312148
155TP63_17297297_ChIP-ChIP_HaCaT_Human0.88112015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.35302405
2MP0003111_abnormal_nucleus_morphology4.21678545
3MP0004957_abnormal_blastocyst_morpholog4.05294074
4MP0010094_abnormal_chromosome_stability3.84259913
5MP0008057_abnormal_DNA_replication3.76224306
6MP0003077_abnormal_cell_cycle3.47532702
7MP0010352_gastrointestinal_tract_polyps3.32696013
8MP0003705_abnormal_hypodermis_morpholog2.81798517
9MP0003123_paternal_imprinting2.75006304
10MP0005451_abnormal_body_composition2.73652998
11MP0001730_embryonic_growth_arrest2.69749353
12MP0010307_abnormal_tumor_latency2.48700292
13MP0000350_abnormal_cell_proliferation2.45651526
14MP0005076_abnormal_cell_differentiation2.33740886
15MP0008438_abnormal_cutaneous_collagen2.33043240
16MP0008058_abnormal_DNA_repair2.31012429
17MP0005380_embryogenesis_phenotype2.18416552
18MP0001672_abnormal_embryogenesis/_devel2.18416552
19MP0004858_abnormal_nervous_system2.14705394
20MP0008007_abnormal_cellular_replicative2.14533852
21MP0002084_abnormal_developmental_patter2.12631936
22MP0008932_abnormal_embryonic_tissue2.06065617
23MP0001697_abnormal_embryo_size2.03678051
24MP0004197_abnormal_fetal_growth/weight/2.03093410
25MP0002085_abnormal_embryonic_tissue2.02556704
26MP0002653_abnormal_ependyma_morphology1.99790978
27MP0002086_abnormal_extraembryonic_tissu1.98303989
28MP0003984_embryonic_growth_retardation1.95585145
29MP0002088_abnormal_embryonic_growth/wei1.92626100
30MP0003453_abnormal_keratinocyte_physiol1.86119159
31MP0002080_prenatal_lethality1.79786067
32MP0000678_abnormal_parathyroid_gland1.79544448
33MP0005058_abnormal_lysosome_morphology1.77450421
34MP0008877_abnormal_DNA_methylation1.74324876
35MP0003786_premature_aging1.69840050
36MP0003119_abnormal_digestive_system1.68662788
37MP0003091_abnormal_cell_migration1.67993098
38MP0003566_abnormal_cell_adhesion1.64246454
39MP0003567_abnormal_fetal_cardiomyocyte1.63787731
40MP0003890_abnormal_embryonic-extraembry1.57273400
41MP0008260_abnormal_autophagy1.57035105
42MP0000537_abnormal_urethra_morphology1.56347342
43MP0010030_abnormal_orbit_morphology1.55632057
44MP0004272_abnormal_basement_membrane1.55256065
45MP0004133_heterotaxia1.54573127
46MP0005409_darkened_coat_color1.52657145
47MP0002796_impaired_skin_barrier1.51745329
48MP0005257_abnormal_intraocular_pressure1.51684051
49MP0000003_abnormal_adipose_tissue1.51550636
50MP0001348_abnormal_lacrimal_gland1.51219181
51MP0001293_anophthalmia1.50264480
52MP0002249_abnormal_larynx_morphology1.48948393
53MP0009053_abnormal_anal_canal1.47292455
54MP0003121_genomic_imprinting1.44394673
55MP0001849_ear_inflammation1.43169739
56MP0010234_abnormal_vibrissa_follicle1.40274754
57MP0005666_abnormal_adipose_tissue1.38887893
58MP0001346_abnormal_lacrimal_gland1.34494899
59MP0009278_abnormal_bone_marrow1.32568615
60MP0003300_gastrointestinal_ulcer1.28722374
61MP0000313_abnormal_cell_death1.27871534
62MP0005375_adipose_tissue_phenotype1.27812330
63MP0000490_abnormal_crypts_of1.26740813
64MP0001661_extended_life_span1.26523920
65MP0002060_abnormal_skin_morphology1.26039291
66MP0009840_abnormal_foam_cell1.25876655
67MP0002396_abnormal_hematopoietic_system1.25102716
68MP0003806_abnormal_nucleotide_metabolis1.23953342
69MP0002089_abnormal_postnatal_growth/wei1.23314036
70MP0003283_abnormal_digestive_organ1.21839736
71MP0003191_abnormal_cellular_cholesterol1.21555765
72MP0002210_abnormal_sex_determination1.17662651
73MP0003941_abnormal_skin_development1.17287721
74MP0002019_abnormal_tumor_incidence1.16476667
75MP0001145_abnormal_male_reproductive1.11521145
76MP0004264_abnormal_extraembryonic_tissu1.11124143
77MP0003718_maternal_effect1.09877001
78MP0001915_intracranial_hemorrhage1.08648738
79MP0000759_abnormal_skeletal_muscle1.08129254
80MP0010630_abnormal_cardiac_muscle1.05762961
81MP0000747_muscle_weakness1.05592847
82MP0000733_abnormal_muscle_development1.04863943
83MP0009703_decreased_birth_body1.02510262
84MP0000428_abnormal_craniofacial_morphol1.02329497
85MP0005023_abnormal_wound_healing1.02159728
86MP0004808_abnormal_hematopoietic_stem1.01640281
87MP0002877_abnormal_melanocyte_morpholog1.01606724
88MP0003303_peritoneal_inflammation1.00564863
89MP0002111_abnormal_tail_morphology0.98892015
90MP0004185_abnormal_adipocyte_glucose0.98498104
91MP0003279_aneurysm0.98183426
92MP0005623_abnormal_meninges_morphology0.97652324
93MP0003329_amyloid_beta_deposits0.97148268
94MP0004947_skin_inflammation0.97135328
95MP0002092_abnormal_eye_morphology0.97040186
96MP0002697_abnormal_eye_size0.95330502
97MP0004087_abnormal_muscle_fiber0.94497490
98MP0005397_hematopoietic_system_phenotyp0.94380993
99MP0001545_abnormal_hematopoietic_system0.94380993
100MP0009672_abnormal_birth_weight0.94307683
101MP0000762_abnormal_tongue_morphology0.92637873
102MP0005621_abnormal_cell_physiology0.90476895
103MP0002925_abnormal_cardiovascular_devel0.89538177
104MP0004233_abnormal_muscle_weight0.88479475
105MP0001929_abnormal_gametogenesis0.87145452
106MP0005384_cellular_phenotype0.86151329
107MP0001216_abnormal_epidermal_layer0.85715812
108MP0000653_abnormal_sex_gland0.85552581
109MP0003115_abnormal_respiratory_system0.85387598
110MP0003937_abnormal_limbs/digits/tail_de0.84069549
111MP0008770_decreased_survivor_rate0.83529263
112MP0000767_abnormal_smooth_muscle0.83084644
113MP0003861_abnormal_nervous_system0.82880712
114MP0002009_preneoplasia0.82442987
115MP0000579_abnormal_nail_morphology0.81671456
116MP0000432_abnormal_head_morphology0.81635080
117MP0001286_abnormal_eye_development0.80852893
118MP0000858_altered_metastatic_potential0.80385482
119MP0000358_abnormal_cell_content/0.78763717
120MP0000681_abnormal_thyroid_gland0.78607382
121MP0003942_abnormal_urinary_system0.77230532
122MP0005501_abnormal_skin_physiology0.76739032
123MP0003385_abnormal_body_wall0.75938780
124MP0003935_abnormal_craniofacial_develop0.74893983
125MP0000516_abnormal_urinary_system0.74383348
126MP0005367_renal/urinary_system_phenotyp0.74383348
127MP0009931_abnormal_skin_appearance0.73673013
128MP0000534_abnormal_ureter_morphology0.72791976
129MP0000371_diluted_coat_color0.72014609
130MP0000750_abnormal_muscle_regeneration0.71697369
131MP0003763_abnormal_thymus_physiology0.71617186
132MP0000751_myopathy0.68608955
133MP0003448_altered_tumor_morphology0.68375207
134MP0003936_abnormal_reproductive_system0.67517214
135MP0003221_abnormal_cardiomyocyte_apopto0.66433108
136MP0000477_abnormal_intestine_morphology0.66290770
137MP0003315_abnormal_perineum_morphology0.66114296
138MP0003755_abnormal_palate_morphology0.64466986
139MP0000266_abnormal_heart_morphology0.64452902
140MP0000703_abnormal_thymus_morphology0.64162884
141MP0005266_abnormal_metabolism0.57636438
142MP0002269_muscular_atrophy0.57520953
143MP0009333_abnormal_splenocyte_physiolog0.57176024
144MP0000627_abnormal_mammary_gland0.57011288

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.30478024
2Abnormality of the astrocytes (HP:0100707)3.93347918
3Astrocytoma (HP:0009592)3.93347918
4Abnormality of the labia minora (HP:0012880)3.81385269
5Selective tooth agenesis (HP:0001592)3.73685744
6Birth length less than 3rd percentile (HP:0003561)3.70235693
7Agnosia (HP:0010524)3.44962141
8Medulloblastoma (HP:0002885)3.30840399
9Protrusio acetabuli (HP:0003179)3.28897564
10Premature rupture of membranes (HP:0001788)3.27133698
11Glioma (HP:0009733)3.17752713
12Colon cancer (HP:0003003)3.12397789
13Breast hypoplasia (HP:0003187)3.10818285
14Neoplasm of the oral cavity (HP:0100649)3.08047334
15Ulnar bowing (HP:0003031)3.00832643
16Rhabdomyosarcoma (HP:0002859)2.90385952
17Missing ribs (HP:0000921)2.88682587
18Absent radius (HP:0003974)2.86851708
19Vertebral compression fractures (HP:0002953)2.85940205
20Patellar aplasia (HP:0006443)2.80312537
21Achilles tendon contracture (HP:0001771)2.78836231
22Aplasia/hypoplasia of the humerus (HP:0006507)2.75701162
23Chromsome breakage (HP:0040012)2.72558110
24Short humerus (HP:0005792)2.70405583
25Insomnia (HP:0100785)2.69828893
26Absent forearm bone (HP:0003953)2.69102172
27Aplasia involving forearm bones (HP:0009822)2.69102172
28Basal cell carcinoma (HP:0002671)2.68403905
29Asymmetry of the thorax (HP:0001555)2.68271219
30Neoplasm of striated muscle (HP:0009728)2.64513272
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64358527
32Abnormality of the lower motor neuron (HP:0002366)2.62502162
33Aplasia/Hypoplasia of the patella (HP:0006498)2.60067800
34Biliary tract neoplasm (HP:0100574)2.57844056
35Deviation of the thumb (HP:0009603)2.56101167
36Proximal placement of thumb (HP:0009623)2.54779369
37Impulsivity (HP:0100710)2.52063974
38Absent thumb (HP:0009777)2.49001005
39Distal lower limb amyotrophy (HP:0008944)2.47167530
40Disproportionate tall stature (HP:0001519)2.46224644
41Facial hemangioma (HP:0000329)2.42437547
42Abnormality of the anterior horn cell (HP:0006802)2.42053809
43Degeneration of anterior horn cells (HP:0002398)2.42053809
44Abnormality of the Achilles tendon (HP:0005109)2.41540863
45Broad distal phalanx of finger (HP:0009836)2.36314968
46Cerebral aneurysm (HP:0004944)2.35568659
47Rib fusion (HP:0000902)2.34356702
48Supernumerary spleens (HP:0009799)2.33227436
49Fragile skin (HP:0001030)2.31302935
50Spinal cord lesions (HP:0100561)2.28775443
51Syringomyelia (HP:0003396)2.28775443
52Malignant gastrointestinal tract tumors (HP:0006749)2.27342836
53Gastrointestinal carcinoma (HP:0002672)2.27342836
54Shawl scrotum (HP:0000049)2.26438381
55Shallow orbits (HP:0000586)2.26426116
56Long palpebral fissure (HP:0000637)2.26129789
57Broad face (HP:0000283)2.25002176
58Oral leukoplakia (HP:0002745)2.24979166
59Meckel diverticulum (HP:0002245)2.24346891
60Ankyloglossia (HP:0010296)2.22684581
61Angiofibromas (HP:0010615)2.21575960
62Adenoma sebaceum (HP:0009720)2.21575960
63Progressive muscle weakness (HP:0003323)2.17785528
64Abnormal number of incisors (HP:0011064)2.17580018
65Esophageal atresia (HP:0002032)2.17113220
66Neoplasm of the pancreas (HP:0002894)2.16990505
67Trismus (HP:0000211)2.16723296
68Increased connective tissue (HP:0009025)2.16554711
69Increased nuchal translucency (HP:0010880)2.15964892
70Carpal bone hypoplasia (HP:0001498)2.15955652
71Dysmetric saccades (HP:0000641)2.15305286
72Abnormality of the ileum (HP:0001549)2.15280348
73Reticulocytopenia (HP:0001896)2.15138272
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.15004526
75Abnormality of chromosome stability (HP:0003220)2.12519552
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.11342421
77Prominent nose (HP:0000448)2.10670798
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.08685929
79Metaphyseal cupping (HP:0003021)2.08184478
80Amaurosis fugax (HP:0100576)2.07653263
81Abnormality of the distal phalanges of the toes (HP:0010182)2.07431072
82Tracheoesophageal fistula (HP:0002575)2.06989780
83Atresia of the external auditory canal (HP:0000413)2.06737362
84Cafe-au-lait spot (HP:0000957)2.06271958
85Spastic diplegia (HP:0001264)2.05224203
86Abnormality of oral frenula (HP:0000190)2.04947146
87Pseudobulbar signs (HP:0002200)2.04892114
88Flat acetabular roof (HP:0003180)2.04864297
89Multiple enchondromatosis (HP:0005701)2.02276171
90Turricephaly (HP:0000262)2.01448567
91Urethral obstruction (HP:0000796)2.01242685
92Spinal muscular atrophy (HP:0007269)1.99997097
93Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98878511
94Short 1st metacarpal (HP:0010034)1.98878511
95Short nail (HP:0001799)1.97813877
96Premature ovarian failure (HP:0008209)1.97572395
97Abnormality of abdominal situs (HP:0011620)1.97072190
98Abdominal situs inversus (HP:0003363)1.97072190
99Mitral regurgitation (HP:0001653)1.96526222
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.96288434
101Abnormality of the preputium (HP:0100587)1.95642119
102Increased variability in muscle fiber diameter (HP:0003557)1.95301146
103Cerebral inclusion bodies (HP:0100314)1.95018299
104Biconcave vertebral bodies (HP:0004586)1.94797227
105Rough bone trabeculation (HP:0100670)1.94706215
106Myelodysplasia (HP:0002863)1.93794167
107Obstructive sleep apnea (HP:0002870)1.93669966
108Subacute progressive viral hepatitis (HP:0006572)1.92622431
109Lower limb amyotrophy (HP:0007210)1.92534964
110Patellar dislocation (HP:0002999)1.91775748
111Distal upper limb amyotrophy (HP:0007149)1.91764687
112Upper limb amyotrophy (HP:0009129)1.91764687
113Abnormality of the salivary glands (HP:0010286)1.91562532
114Spinal rigidity (HP:0003306)1.91511665
115Duodenal stenosis (HP:0100867)1.90299350
116Small intestinal stenosis (HP:0012848)1.90299350
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.89475544
118Osteolytic defects of the hand bones (HP:0009699)1.89475544
119Arnold-Chiari malformation (HP:0002308)1.88539738
120Genu recurvatum (HP:0002816)1.87970795
121Pelvic girdle muscle weakness (HP:0003749)1.87716583
122Back pain (HP:0003418)1.87588235
123Rectovaginal fistula (HP:0000143)1.87142594
124Rectal fistula (HP:0100590)1.87142594
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.87001606
126Elbow flexion contracture (HP:0002987)1.86008519
127Thin bony cortex (HP:0002753)1.85898136
128Squamous cell carcinoma (HP:0002860)1.85666494
129Blue sclerae (HP:0000592)1.85008392
13011 pairs of ribs (HP:0000878)1.84626639
131Ectopic kidney (HP:0000086)1.84295840
132Overriding aorta (HP:0002623)1.84143327
133Mitral valve prolapse (HP:0001634)1.83925832
134Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83648269
135Skin tags (HP:0010609)1.83288353
136Stenosis of the external auditory canal (HP:0000402)1.83265804
137Hyperparathyroidism (HP:0000843)1.82873487
138Distal lower limb muscle weakness (HP:0009053)1.82449513
139Ankle contracture (HP:0006466)1.81539580
140Preauricular skin tag (HP:0000384)1.81340620
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80246690
142Short 4th metacarpal (HP:0010044)1.80246690
143Dislocated radial head (HP:0003083)1.79604121
144Abnormality of skeletal muscle fiber size (HP:0012084)1.78742519
145Premature skin wrinkling (HP:0100678)1.78467588
146Elfin facies (HP:0004428)1.78337215
147High pitched voice (HP:0001620)1.78160734
148Supernumerary ribs (HP:0005815)1.77266864
149Hyperacusis (HP:0010780)1.77091836
150Abnormality of the umbilical cord (HP:0010881)1.77076954
151Abnormality of the calcaneus (HP:0008364)1.77068459
152Heterotopia (HP:0002282)1.76785414
153Intestinal fistula (HP:0100819)1.76428727
154Vertebral fusion (HP:0002948)1.76348724
155Vertebral clefting (HP:0008428)1.76198821
156Spinal cord compression (HP:0002176)1.76120480
157Deep palmar crease (HP:0006191)1.76050336
158Broad thumb (HP:0011304)1.75537106
159Renal duplication (HP:0000075)1.75418706
160Pointed chin (HP:0000307)1.74873917
161Germ cell neoplasia (HP:0100728)1.74625563
162Truncus arteriosus (HP:0001660)1.74077811
163Abnormality of the thoracic spine (HP:0100711)1.72937537
164Bladder diverticulum (HP:0000015)1.71948921
165Stridor (HP:0010307)1.70029319
166Unilateral renal agenesis (HP:0000122)1.69565896
167Wormian bones (HP:0002645)1.69526614
168Abnormality of the phalanges of the hallux (HP:0010057)1.69310777
169Dilatation of the ascending aorta (HP:0005111)1.68022970
170Transposition of the great arteries (HP:0001669)1.67995386
171Abnormal connection of the cardiac segments (HP:0011545)1.67995386
172Abnormal ventriculo-arterial connection (HP:0011563)1.67995386
173Atrophic scars (HP:0001075)1.67847268
174Ragged-red muscle fibers (HP:0003200)1.67140190
175Abnormal ossification of hand bones (HP:0005921)1.66771837
176Progressive external ophthalmoplegia (HP:0000590)1.64166364
177Insidious onset (HP:0003587)1.64158908
178Termporal pattern (HP:0011008)1.64158908
179Rectal prolapse (HP:0002035)1.63472649
180Abnormality of the radial head (HP:0003995)1.62931236
181Orthostatic hypotension (HP:0001278)1.62499006
182Polygenic inheritance (HP:0010982)1.62099025
183Advanced eruption of teeth (HP:0006288)1.61460213
184Cellulitis (HP:0100658)1.60681962
185Difficulty climbing stairs (HP:0003551)1.60059394
186Sparse lateral eyebrow (HP:0005338)1.59844337
187Arterial tortuosity (HP:0005116)1.59372087
188Abnormality of the tricuspid valve (HP:0001702)1.59207236
189Abnormality of the fingertips (HP:0001211)1.56885150
190Bowel incontinence (HP:0002607)1.56806787
191Leiomyosarcoma (HP:0100243)1.55557342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.67148669
2CDK124.13951709
3WEE13.68676911
4CDC73.50438940
5PRPF4B3.26471271
6IRAK33.25468981
7NEK23.02559518
8EPHA23.00446221
9NEK12.84820481
10BUB12.83299137
11TTK2.64120896
12EEF2K2.47863191
13RPS6KB22.32065752
14TSSK62.27609839
15PKN22.23353307
16ALK1.86690095
17SIK11.83136809
18CDK71.82743530
19PLK11.78012081
20MAP3K101.69657426
21SCYL21.67248544
22ACVR1B1.58989448
23LATS21.58468058
24ERN11.56565190
25BRD41.54791089
26PASK1.54034808
27ATR1.53105514
28MAP3K81.51827094
29CDK41.51611276
30PNCK1.50355754
31CHEK21.50026939
32SRPK11.49344154
33CHEK11.41548789
34TRIB31.40879584
35PAK41.34778803
36PLK31.31654166
37FGFR41.30480745
38STK101.29983867
39AURKB1.27347743
40MAP3K131.24174426
41ARAF1.21067477
42EIF2AK11.16805851
43MTOR1.15695406
44DYRK31.14762657
45ICK1.11286198
46TAF11.11101038
47CDK61.08612721
48CDK21.06088643
49MKNK11.05724686
50STK31.04416186
51NTRK11.03662753
52BRSK21.03583313
53IRAK21.03182503
54PIM11.01569880
55VRK20.99410400
56ATM0.98901399
57AKT30.97259201
58AURKA0.96270567
59RPS6KA40.96226087
60TGFBR10.95101463
61BRAF0.94856809
62MKNK20.93210211
63LATS10.91411807
64CAMK1D0.90852424
65PTK20.89974004
66BMX0.88296456
67STK38L0.88275778
68MAPKAPK30.86169869
69MAPK110.85841399
70TLK10.85086836
71STK40.84316947
72PDPK10.83989292
73MST1R0.81780513
74MAP3K10.81502296
75PRKCI0.75817266
76PDGFRA0.75608475
77TESK20.75121459
78FLT30.73558042
79PAK20.73148216
80RPS6KA20.72147725
81TYRO30.70202488
82CDK80.69839653
83CDK10.69304968
84CSNK1E0.69062986
85TTN0.67705370
86ILK0.66848327
87PLK40.66228364
88AKT20.66141296
89CAMK1G0.65235228
90MAP3K110.64623093
91MELK0.64273324
92PDK30.64000619
93PDK40.64000619
94MOS0.63672288
95NME20.63147886
96IRAK40.62254279
97LRRK20.62252031
98MAP2K30.61491923
99CSNK1D0.60703793
100PAK10.59775746
101CDC42BPA0.59568520
102RPS6KL10.59197753
103RPS6KC10.59197753
104CSNK2A20.59072955
105TAOK20.58227356
106DDR20.57655487
107LMTK20.56343139
108BRSK10.56067947
109MAP3K140.55629872
110GRK60.55221231
111TESK10.55124799
112ZAK0.54963752
113KDR0.54562763
114MAP3K90.54351070
115KSR20.54136448
116HIPK20.53987741
117KSR10.53760090
118CDK90.53214389
119MARK20.52946876
120PRKD20.51230221
121FGFR10.50966976
122CAMKK10.49404564
123PRKDC0.49078105
124MAP2K20.48372795
125PRKD30.48261291
126MAP3K50.45142886
127EIF2AK30.43945023
128PTK60.43634230
129ERBB40.42346144
130PDK10.41691410
131MAPK140.41329191
132DAPK30.39689537
133RET0.38733141
134CSNK2A10.38534248
135CDK11A0.38415968
136RIPK10.37280479
137RPS6KA10.36970889
138CDK150.36965377
139MAP3K60.35980846
140PRKG20.35388082
141MAPK10.34931571
142GSK3B0.34384968
143RPS6KA60.33543098
144TAOK10.32394768
145MAP3K30.32155180
146AKT10.32047945
147DAPK10.31908154
148CDK180.30653809
149MET0.30469428
150MARK30.30094106

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15799528
2DNA replication_Homo sapiens_hsa030303.94273384
3Mismatch repair_Homo sapiens_hsa034303.78602277
4RNA transport_Homo sapiens_hsa030133.67105524
5Spliceosome_Homo sapiens_hsa030403.15301834
6One carbon pool by folate_Homo sapiens_hsa006703.01539576
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.79171954
8Cell cycle_Homo sapiens_hsa041102.73925726
9Base excision repair_Homo sapiens_hsa034102.45913576
10Nucleotide excision repair_Homo sapiens_hsa034202.36415885
11mRNA surveillance pathway_Homo sapiens_hsa030152.35994778
12RNA polymerase_Homo sapiens_hsa030202.28291549
13Homologous recombination_Homo sapiens_hsa034402.17800679
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.08063656
15Fanconi anemia pathway_Homo sapiens_hsa034601.92902387
16p53 signaling pathway_Homo sapiens_hsa041151.77194784
17Ribosome_Homo sapiens_hsa030101.70868550
18RNA degradation_Homo sapiens_hsa030181.70182927
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64700203
20Pyrimidine metabolism_Homo sapiens_hsa002401.54877382
21Basal transcription factors_Homo sapiens_hsa030221.48848906
22Other glycan degradation_Homo sapiens_hsa005111.45725290
23Prion diseases_Homo sapiens_hsa050201.41597286
24Oocyte meiosis_Homo sapiens_hsa041141.33384904
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31958263
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31838798
27B cell receptor signaling pathway_Homo sapiens_hsa046621.30827065
28Non-homologous end-joining_Homo sapiens_hsa034501.30345378
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28723042
30Proteasome_Homo sapiens_hsa030501.28360514
31Biosynthesis of amino acids_Homo sapiens_hsa012301.27951511
32Hippo signaling pathway_Homo sapiens_hsa043901.23945896
33Viral carcinogenesis_Homo sapiens_hsa052031.22922726
34ErbB signaling pathway_Homo sapiens_hsa040121.19585068
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19034073
36MicroRNAs in cancer_Homo sapiens_hsa052061.18110178
37Insulin signaling pathway_Homo sapiens_hsa049101.14668350
38mTOR signaling pathway_Homo sapiens_hsa041501.14058745
39Epstein-Barr virus infection_Homo sapiens_hsa051691.12441288
40Systemic lupus erythematosus_Homo sapiens_hsa053221.09878706
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04254127
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02335802
43HTLV-I infection_Homo sapiens_hsa051661.00796493
44Small cell lung cancer_Homo sapiens_hsa052220.99639612
45Basal cell carcinoma_Homo sapiens_hsa052170.98590627
46Notch signaling pathway_Homo sapiens_hsa043300.98547870
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98532818
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96334631
49Herpes simplex infection_Homo sapiens_hsa051680.95442362
50Antigen processing and presentation_Homo sapiens_hsa046120.91655605
51TGF-beta signaling pathway_Homo sapiens_hsa043500.91507196
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.91021075
53Thyroid cancer_Homo sapiens_hsa052160.90885486
54GnRH signaling pathway_Homo sapiens_hsa049120.89239736
55Adherens junction_Homo sapiens_hsa045200.89184553
56AMPK signaling pathway_Homo sapiens_hsa041520.88109354
57Bladder cancer_Homo sapiens_hsa052190.86658083
58Estrogen signaling pathway_Homo sapiens_hsa049150.84011341
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.83306558
60Colorectal cancer_Homo sapiens_hsa052100.82837779
61Selenocompound metabolism_Homo sapiens_hsa004500.82262337
62Vitamin B6 metabolism_Homo sapiens_hsa007500.80462039
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.79961459
64Chronic myeloid leukemia_Homo sapiens_hsa052200.78724219
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78024757
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.77402298
67Inositol phosphate metabolism_Homo sapiens_hsa005620.77101248
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.76253003
69Prolactin signaling pathway_Homo sapiens_hsa049170.75923767
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73425481
71Long-term potentiation_Homo sapiens_hsa047200.73374610
72Choline metabolism in cancer_Homo sapiens_hsa052310.70896351
73HIF-1 signaling pathway_Homo sapiens_hsa040660.70269847
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.70079560
75Amoebiasis_Homo sapiens_hsa051460.70064933
76Hepatitis C_Homo sapiens_hsa051600.70016959
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69797986
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69388924
79Hedgehog signaling pathway_Homo sapiens_hsa043400.69036476
80Pentose phosphate pathway_Homo sapiens_hsa000300.68101919
81Purine metabolism_Homo sapiens_hsa002300.68096480
82Lysine degradation_Homo sapiens_hsa003100.67145550
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65004176
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64133296
85Proteoglycans in cancer_Homo sapiens_hsa052050.63291238
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62424435
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61634067
88N-Glycan biosynthesis_Homo sapiens_hsa005100.61382001
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60973958
90Vibrio cholerae infection_Homo sapiens_hsa051100.60795047
91Sulfur relay system_Homo sapiens_hsa041220.60587613
92Tight junction_Homo sapiens_hsa045300.60366167
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.59410969
94Melanogenesis_Homo sapiens_hsa049160.59171820
95ECM-receptor interaction_Homo sapiens_hsa045120.56995191
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56572866
97Endocytosis_Homo sapiens_hsa041440.56039183
98Osteoclast differentiation_Homo sapiens_hsa043800.55790460
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55581196
100Fructose and mannose metabolism_Homo sapiens_hsa000510.55037635
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.53936953
102Apoptosis_Homo sapiens_hsa042100.53829618
103Insulin resistance_Homo sapiens_hsa049310.53775042
104Endometrial cancer_Homo sapiens_hsa052130.53141992
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.53129759
106Toxoplasmosis_Homo sapiens_hsa051450.53016103
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52376371
108Pathways in cancer_Homo sapiens_hsa052000.52100371
109TNF signaling pathway_Homo sapiens_hsa046680.51041605
110Carbon metabolism_Homo sapiens_hsa012000.50910208
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50715058
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50454514
113Legionellosis_Homo sapiens_hsa051340.50187642
114Acute myeloid leukemia_Homo sapiens_hsa052210.49590615
115Non-small cell lung cancer_Homo sapiens_hsa052230.48145853
116Prostate cancer_Homo sapiens_hsa052150.46232901
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44886440
118Hepatitis B_Homo sapiens_hsa051610.42862984
119Alcoholism_Homo sapiens_hsa050340.42241550
120Wnt signaling pathway_Homo sapiens_hsa043100.39555705
121Shigellosis_Homo sapiens_hsa051310.38606356
122Melanoma_Homo sapiens_hsa052180.37722558
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35451566
124VEGF signaling pathway_Homo sapiens_hsa043700.34930189
125Renal cell carcinoma_Homo sapiens_hsa052110.34915060
126Influenza A_Homo sapiens_hsa051640.34467725
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.34440167
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33248818
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32963765
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32290181
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31788434
132Focal adhesion_Homo sapiens_hsa045100.31049769
133FoxO signaling pathway_Homo sapiens_hsa040680.30917595
134Folate biosynthesis_Homo sapiens_hsa007900.29899698
135Viral myocarditis_Homo sapiens_hsa054160.29007072
136Pancreatic cancer_Homo sapiens_hsa052120.27186740
137Galactose metabolism_Homo sapiens_hsa000520.26634538
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26460288
139Dorso-ventral axis formation_Homo sapiens_hsa043200.26183640
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26070959
141Glioma_Homo sapiens_hsa052140.25599434

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