SEMA6C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)8.60790838
2gonadal mesoderm development (GO:0007506)8.33151899
3myofibril assembly (GO:0030239)6.67418837
4striated muscle contraction (GO:0006941)6.43660138
5actin filament-based movement (GO:0030048)6.42443328
6creatine metabolic process (GO:0006600)6.39817925
7positive regulation of male gonad development (GO:2000020)6.32431174
8regulation of relaxation of muscle (GO:1901077)6.21912284
9sarcomere organization (GO:0045214)5.96527437
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.81774663
11layer formation in cerebral cortex (GO:0021819)5.67462569
12response to muscle activity (GO:0014850)5.64686905
13cardiac myofibril assembly (GO:0055003)5.64038134
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.56675787
15pyrimidine nucleobase catabolic process (GO:0006208)5.54480446
16regulation of male gonad development (GO:2000018)5.44057905
17sex determination (GO:0007530)5.26076321
18cardiac muscle contraction (GO:0060048)5.16443154
19myotube cell development (GO:0014904)5.04090996
20axonal fasciculation (GO:0007413)4.95759890
21muscle contraction (GO:0006936)4.94237737
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.71980322
23cell migration in hindbrain (GO:0021535)4.70147885
24actomyosin structure organization (GO:0031032)4.63774299
25regulation of actin filament-based movement (GO:1903115)4.57609736
26skeletal muscle adaptation (GO:0043501)4.55873452
27muscle system process (GO:0003012)4.39656484
28male sex determination (GO:0030238)4.39607883
29muscle fiber development (GO:0048747)4.33081517
30regulation of cell communication by electrical coupling (GO:0010649)4.31248014
31glycogen catabolic process (GO:0005980)4.29494268
32cardiac muscle hypertrophy (GO:0003300)4.26170608
33response to pheromone (GO:0019236)4.23873925
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.22401225
35nucleobase catabolic process (GO:0046113)4.19831673
36striated muscle hypertrophy (GO:0014897)4.11512247
37positive regulation of synapse maturation (GO:0090129)4.10383248
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07412963
39neuron recognition (GO:0008038)4.05554477
40glucan catabolic process (GO:0009251)4.01300864
41neuronal action potential propagation (GO:0019227)3.99109456
42NADH metabolic process (GO:0006734)3.95502174
43striated muscle adaptation (GO:0014888)3.93991222
44skeletal muscle tissue development (GO:0007519)3.93108871
45negative regulation of catenin import into nucleus (GO:0035414)3.81906223
46establishment of nucleus localization (GO:0040023)3.78431949
47glycogen biosynthetic process (GO:0005978)3.72216953
48glucan biosynthetic process (GO:0009250)3.72216953
49cellular polysaccharide catabolic process (GO:0044247)3.69823474
502-oxoglutarate metabolic process (GO:0006103)3.67440608
51neuronal ion channel clustering (GO:0045161)3.61806181
52muscle hypertrophy (GO:0014896)3.60274377
53sex differentiation (GO:0007548)3.58781248
54regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57743887
55glial cell proliferation (GO:0014009)3.56940628
56muscle cell fate commitment (GO:0042693)3.55483489
57muscle tissue morphogenesis (GO:0060415)3.54262370
58regulation of meiosis I (GO:0060631)3.53834358
59regulation of calcium ion transmembrane transporter activity (GO:1901019)3.53638811
60regulation of calcium ion transmembrane transport (GO:1903169)3.53638811
61adult heart development (GO:0007512)3.51834297
62myoblast fusion (GO:0007520)3.50911798
63regulation of striated muscle contraction (GO:0006942)3.50122596
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.47961360
65muscle organ development (GO:0007517)3.47864751
66neuromuscular synaptic transmission (GO:0007274)3.47526595
67muscle structure development (GO:0061061)3.47353036
68cardiac muscle tissue morphogenesis (GO:0055008)3.43919589
69regulation of membrane repolarization (GO:0060306)3.43420855
70positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.38497702
71cardiac muscle adaptation (GO:0014887)3.38374508
72cardiac muscle hypertrophy in response to stress (GO:0014898)3.38374508
73muscle hypertrophy in response to stress (GO:0003299)3.38374508
74striated muscle cell development (GO:0055002)3.37564749
75sodium ion export (GO:0071436)3.34918608
76ovulation cycle (GO:0042698)3.32981696
77polysaccharide catabolic process (GO:0000272)3.28996637
78skeletal muscle tissue regeneration (GO:0043403)3.26142829
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25058888
80muscle cell cellular homeostasis (GO:0046716)3.23702732
81regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22205004
82substrate-independent telencephalic tangential migration (GO:0021826)3.22083526
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.22083526
84semaphorin-plexin signaling pathway (GO:0071526)3.20726105
85central nervous system projection neuron axonogenesis (GO:0021952)3.19894521
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17760654
87negative regulation of calcium ion transmembrane transport (GO:1903170)3.16154566
88negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.16154566
89axon extension (GO:0048675)3.16139601
90myotube differentiation (GO:0014902)3.15994046
91regulation of skeletal muscle contraction (GO:0014819)3.14901111
92dendritic spine morphogenesis (GO:0060997)3.11945517
93fructose metabolic process (GO:0006000)3.11730005
94plasma membrane repair (GO:0001778)3.10724165
95cardiac muscle cell development (GO:0055013)3.10240407
96negative regulation of microtubule polymerization (GO:0031115)3.09141144
97gluconeogenesis (GO:0006094)3.09127303
98muscle adaptation (GO:0043500)3.07751054
99glycogen metabolic process (GO:0005977)3.07213705
100dendrite morphogenesis (GO:0048813)3.05395718
101presynaptic membrane organization (GO:0097090)3.05202053
102syncytium formation by plasma membrane fusion (GO:0000768)3.05103299
103regulation of the force of heart contraction (GO:0002026)3.00841624
104growth hormone secretion (GO:0030252)3.00808662
105cellular glucan metabolic process (GO:0006073)3.00323803
106glucan metabolic process (GO:0044042)3.00323803
107anatomical structure regression (GO:0060033)2.98659754
108muscle cell development (GO:0055001)2.97647654
109carnitine shuttle (GO:0006853)2.97436017
110neuron cell-cell adhesion (GO:0007158)2.97414865
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96829780
112otic vesicle formation (GO:0030916)2.96573905
113muscle organ morphogenesis (GO:0048644)2.96037645
114cardiac cell development (GO:0055006)2.93995482
115response to inactivity (GO:0014854)2.91798877
116striated muscle atrophy (GO:0014891)2.91735455
117skeletal muscle organ development (GO:0060538)2.90800332
118response to activity (GO:0014823)2.90415133
119regulation of synapse maturation (GO:0090128)2.89971693
120macroautophagy (GO:0016236)2.89624432
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88903241
122cerebellar Purkinje cell differentiation (GO:0021702)2.88227143
123regulation of NFAT protein import into nucleus (GO:0051532)2.86197700
124locomotory exploration behavior (GO:0035641)2.85606116
125negative regulation of protein localization to cell surface (GO:2000009)2.84865889
126vocalization behavior (GO:0071625)2.84143566
127cell communication by electrical coupling (GO:0010644)2.83902125
128positive regulation of cation channel activity (GO:2001259)2.83602264
129negative regulation of potassium ion transmembrane transport (GO:1901380)2.82540596
130regulation of synapse structural plasticity (GO:0051823)2.80919809
131positive regulation of axon extension (GO:0045773)2.80666609
132respiratory system process (GO:0003016)2.80237746
133striated muscle tissue development (GO:0014706)2.80025915
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79370333
135nucleus localization (GO:0051647)2.78972768
136membrane depolarization during action potential (GO:0086010)2.78845564
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77834985
138synaptic vesicle maturation (GO:0016188)2.77579003
139regulation of sequestering of triglyceride (GO:0010889)2.76494190
140positive regulation of dendrite morphogenesis (GO:0050775)2.75361736
141hippocampus development (GO:0021766)2.75270183
142hexose biosynthetic process (GO:0019319)2.74340602
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70541063
144embryonic foregut morphogenesis (GO:0048617)2.68652470
145forebrain neuron differentiation (GO:0021879)2.68543742
146protein localization to synapse (GO:0035418)2.66570201
147synaptic vesicle docking involved in exocytosis (GO:0016081)2.65021401
148negative regulation of organelle assembly (GO:1902116)2.64817443
149diaphragm development (GO:0060539)2.64080384
150ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.64027208
151histone H3-K36 demethylation (GO:0070544)2.63490697
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62984291
153neuron projection extension (GO:1990138)2.62387243
154cerebellum development (GO:0021549)2.59625011
155positive regulation of axonogenesis (GO:0050772)2.59172102
156regulation of neuronal synaptic plasticity (GO:0048168)2.57107979
157regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.57084986
158negative regulation of cell size (GO:0045792)2.56645559
159piRNA metabolic process (GO:0034587)2.56518879
160positive regulation of meiosis (GO:0045836)2.55887179
161developmental cell growth (GO:0048588)2.54784560
162sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51815809
163negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.51005132
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.49675323
165cerebellar Purkinje cell layer development (GO:0021680)2.48712172
166skeletal muscle fiber development (GO:0048741)2.48574219
167regulation of glutamate receptor signaling pathway (GO:1900449)2.48555167
168positive regulation of dendrite development (GO:1900006)2.48469812
169muscle filament sliding (GO:0030049)2.48213274
170actin-myosin filament sliding (GO:0033275)2.48213274
171peptidyl-lysine dimethylation (GO:0018027)2.47497612
172positive regulation of dendritic spine morphogenesis (GO:0061003)2.47259397
173synaptonemal complex assembly (GO:0007130)2.46252486
174proximal/distal pattern formation (GO:0009954)2.46006877
175regulation of skeletal muscle cell differentiation (GO:2001014)2.44966170
176exploration behavior (GO:0035640)2.44913447
177regulation of synaptic vesicle exocytosis (GO:2000300)2.44573786
178regulation of gonadotropin secretion (GO:0032276)2.43183537
179regulation of axon extension (GO:0030516)2.42863823
180histone H4-K8 acetylation (GO:0043982)2.42829271
181histone H4-K5 acetylation (GO:0043981)2.42829271
182synaptic vesicle endocytosis (GO:0048488)2.42323852
183neuromuscular junction development (GO:0007528)2.41721421
184postsynaptic membrane organization (GO:0001941)2.41698271
185skeletal muscle contraction (GO:0003009)2.40611831
186positive regulation of myotube differentiation (GO:0010831)2.40174427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19333755
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.55678715
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.08280600
4ZFP281_18757296_ChIP-ChIP_E14_Mouse2.92008799
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.81142155
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67205685
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.62602718
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57039931
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47575390
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47575390
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44691014
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.34239517
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.31773920
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27828938
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21895495
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18885387
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15539308
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13492198
19* KDM2B_26808549_Chip-Seq_K562_Human2.12423677
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09352465
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08086771
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07912520
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.99196408
24DROSHA_22980978_ChIP-Seq_HELA_Human1.98632174
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95576129
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.93470582
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92489228
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90529043
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84888350
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.84493263
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84259617
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80858197
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77162582
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.77085984
35* KDM2B_26808549_Chip-Seq_DND41_Human1.76967404
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76791589
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76265842
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73525341
39* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.73065086
40ZNF263_19887448_ChIP-Seq_K562_Human1.72410732
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.71558338
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.71558338
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71406144
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.68813928
45REST_21632747_ChIP-Seq_MESCs_Mouse1.67028812
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64829957
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64826450
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.63307379
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63218011
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.63170744
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62440637
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.62168713
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60044148
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58551456
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57082428
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.56960305
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51121839
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.50398334
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50048268
60CTCF_27219007_Chip-Seq_Bcells_Human1.48410694
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.48072336
62CREB1_26743006_Chip-Seq_LNCaP_Human1.46030617
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45907253
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.44688516
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44230599
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43713582
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42183068
68* LXR_22292898_ChIP-Seq_THP-1_Human1.41435284
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41048255
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38309156
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37386381
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30973412
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26895236
74RNF2_27304074_Chip-Seq_NSC_Mouse1.26184357
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.25054462
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24786742
77* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23123487
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23094660
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.22977771
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22213203
81ZNF274_21170338_ChIP-Seq_K562_Hela1.21020812
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20374278
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18995651
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18687239
85TCF7_22412390_ChIP-Seq_EML_Mouse1.18355024
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18240003
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.16299234
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16295041
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.14872994
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12005165
91MYC_27129775_Chip-Seq_CORNEA_Mouse1.11692622
92* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11422289
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10594939
94GBX2_23144817_ChIP-Seq_PC3_Human1.09840140
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.08941167
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07605214
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06193758
98AR_21572438_ChIP-Seq_LNCaP_Human1.05997678
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05749677
100AR_19668381_ChIP-Seq_PC3_Human1.02412691
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01136157
102SA1_27219007_Chip-Seq_Bcells_Human1.00535382
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97372654
104BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97274361
105SOX3_22085726_ChIP-Seq_NPCs_Mouse0.96399372
106SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96048518
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95187835
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94371910
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93669564
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93521312
111SMC4_20622854_ChIP-Seq_HELA_Human0.92358134
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89672343
113OCT4_19829295_ChIP-Seq_ESCs_Human0.88203847
114TP53_22127205_ChIP-Seq_IMR90_Human0.87509969
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87296276
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87165052
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.86773071
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86607536
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86316601
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85625315
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.85319072
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85061094
123IGF1R_20145208_ChIP-Seq_DFB_Human0.83784467
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83215907
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83063994
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81466760
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81170362
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.80864856
129KLF4_19829295_ChIP-Seq_ESCs_Human0.80604256
130* SA1_27219007_Chip-Seq_ERYTHROID_Human0.80474555
131P68_20966046_ChIP-Seq_HELA_Human0.80439874
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.79766332
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79522145
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.78024028
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.76773789
136POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76599968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.90594067
2MP0005423_abnormal_somatic_nervous3.58697420
3MP0004859_abnormal_synaptic_plasticity3.58142314
4MP0004145_abnormal_muscle_electrophysio3.50855421
5MP0000751_myopathy3.35586149
6MP0000778_abnormal_nervous_system2.62172902
7MP0002653_abnormal_ependyma_morphology2.56412853
8MP0002332_abnormal_exercise_endurance2.55181420
9MP0004270_analgesia2.46385325
10MP0005451_abnormal_body_composition2.42098600
11MP0005330_cardiomyopathy2.34255143
12MP0003878_abnormal_ear_physiology1.98063947
13MP0005377_hearing/vestibular/ear_phenot1.98063947
14MP0002972_abnormal_cardiac_muscle1.93979186
15MP0000537_abnormal_urethra_morphology1.92903996
16MP0003635_abnormal_synaptic_transmissio1.89651191
17MP0003122_maternal_imprinting1.87117144
18MP0005623_abnormal_meninges_morphology1.84153704
19MP0008877_abnormal_DNA_methylation1.78514926
20MP0004215_abnormal_myocardial_fiber1.76865619
21MP0004858_abnormal_nervous_system1.70822372
22MP0002822_catalepsy1.69766704
23MP0003315_abnormal_perineum_morphology1.68087957
24MP0002063_abnormal_learning/memory/cond1.66723634
25MP0002184_abnormal_innervation1.62410477
26MP0004233_abnormal_muscle_weight1.61061902
27MP0008961_abnormal_basal_metabolism1.59249873
28MP0001440_abnormal_grooming_behavior1.56948443
29MP0003283_abnormal_digestive_organ1.55241701
30MP0003119_abnormal_digestive_system1.55053173
31MP0010630_abnormal_cardiac_muscle1.54323020
32MP0009780_abnormal_chondrocyte_physiolo1.52925484
33MP0000955_abnormal_spinal_cord1.52430876
34MP0002106_abnormal_muscle_physiology1.51203879
35MP0006276_abnormal_autonomic_nervous1.50775361
36MP0004811_abnormal_neuron_physiology1.49895293
37MP0003646_muscle_fatigue1.48739250
38MP0000747_muscle_weakness1.48696325
39MP0000631_abnormal_neuroendocrine_gland1.48252933
40MP0004885_abnormal_endolymph1.44965163
41MP0000733_abnormal_muscle_development1.43063684
42MP0003880_abnormal_central_pattern1.42034581
43MP0000759_abnormal_skeletal_muscle1.41396223
44MP0004484_altered_response_of1.38849872
45MP0003879_abnormal_hair_cell1.38847128
46MP0003942_abnormal_urinary_system1.38609082
47MP0002127_abnormal_cardiovascular_syste1.35978073
48MP0000569_abnormal_digit_pigmentation1.35395590
49MP0006036_abnormal_mitochondrial_physio1.35223772
50MP0005187_abnormal_penis_morphology1.34472474
51MP0004087_abnormal_muscle_fiber1.32903795
52MP0004036_abnormal_muscle_relaxation1.31505508
53MP0002234_abnormal_pharynx_morphology1.30763697
54MP0005385_cardiovascular_system_phenoty1.27452187
55MP0001544_abnormal_cardiovascular_syste1.27452187
56MP0000749_muscle_degeneration1.27177300
57MP0000013_abnormal_adipose_tissue1.26773541
58MP0003861_abnormal_nervous_system1.24328772
59MP0005369_muscle_phenotype1.24315238
60MP0003121_genomic_imprinting1.24250109
61MP0002734_abnormal_mechanical_nocicepti1.20453887
62MP0002882_abnormal_neuron_morphology1.19279529
63MP0010030_abnormal_orbit_morphology1.17438369
64MP0002572_abnormal_emotion/affect_behav1.16026547
65MP0005645_abnormal_hypothalamus_physiol1.15556755
66MP0001486_abnormal_startle_reflex1.15477388
67MP0009384_cardiac_valve_regurgitation1.15317329
68MP0009046_muscle_twitch1.14962381
69MP0002152_abnormal_brain_morphology1.14570530
70MP0004510_myositis1.14470697
71MP0003115_abnormal_respiratory_system1.14403288
72MP0005266_abnormal_metabolism1.12608940
73MP0005076_abnormal_cell_differentiation1.11508364
74MP0002102_abnormal_ear_morphology1.11448196
75MP0004134_abnormal_chest_morphology1.10628895
76MP0000534_abnormal_ureter_morphology1.10251657
77MP0003786_premature_aging1.09891616
78MP0004084_abnormal_cardiac_muscle1.08597703
79MP0005248_abnormal_Harderian_gland1.08248147
80MP0005670_abnormal_white_adipose1.06129233
81MP0002557_abnormal_social/conspecific_i1.05972147
82MP0002064_seizures1.05934555
83MP0003385_abnormal_body_wall1.04886658
84MP0009745_abnormal_behavioral_response1.03885892
85MP0003137_abnormal_impulse_conducting1.00906207
86MP0002971_abnormal_brown_adipose1.00809392
87MP0003787_abnormal_imprinting0.99658854
88MP0001727_abnormal_embryo_implantation0.98684942
89MP0005620_abnormal_muscle_contractility0.98660997
90MP0000750_abnormal_muscle_regeneration0.96934743
91MP0003329_amyloid_beta_deposits0.96307553
92MP0002269_muscular_atrophy0.96207373
93MP0001984_abnormal_olfaction0.94711969
94MP0008569_lethality_at_weaning0.94340249
95MP0004742_abnormal_vestibular_system0.93489458
96MP0008775_abnormal_heart_ventricle0.93189419
97MP0002638_abnormal_pupillary_reflex0.91688609
98MP0002210_abnormal_sex_determination0.91649116
99MP0002081_perinatal_lethality0.91167788
100MP0000428_abnormal_craniofacial_morphol0.90452905
101MP0002108_abnormal_muscle_morphology0.90284975
102MP0003698_abnormal_male_reproductive0.90258962
103MP0004085_abnormal_heartbeat0.90026806
104MP0004130_abnormal_muscle_cell0.89202512
105MP0002066_abnormal_motor_capabilities/c0.87604007
106MP0002837_dystrophic_cardiac_calcinosis0.87586149
107MP0005375_adipose_tissue_phenotype0.86482257
108MP0000003_abnormal_adipose_tissue0.86361837
109MP0003123_paternal_imprinting0.85738709
110MP0005666_abnormal_adipose_tissue0.85638146
111MP0002067_abnormal_sensory_capabilities0.84808024
112* MP0002733_abnormal_thermal_nociception0.84395987
113MP0002282_abnormal_trachea_morphology0.84037106
114MP0002272_abnormal_nervous_system0.83475114
115MP0002909_abnormal_adrenal_gland0.83215007
116MP0003221_abnormal_cardiomyocyte_apopto0.82701101
117MP0003705_abnormal_hypodermis_morpholog0.79941091
118MP0002249_abnormal_larynx_morphology0.79875017
119MP0004185_abnormal_adipocyte_glucose0.79872187
120MP0002116_abnormal_craniofacial_bone0.79629517
121MP0006138_congestive_heart_failure0.76615447
122MP0003045_fibrosis0.75417824
123MP0002751_abnormal_autonomic_nervous0.75395647
124MP0001299_abnormal_eye_distance/0.73930321
125MP0001145_abnormal_male_reproductive0.73084707
126MP0004272_abnormal_basement_membrane0.72345796
127MP0001346_abnormal_lacrimal_gland0.70424490
128MP0004142_abnormal_muscle_tone0.68514782
129MP0001661_extended_life_span0.63930420
130MP0000266_abnormal_heart_morphology0.63547488
131MP0001502_abnormal_circadian_rhythm0.62504843
132MP0001529_abnormal_vocalization0.60444033
133MP0005409_darkened_coat_color0.57326125
134MP0003948_abnormal_gas_homeostasis0.53755970
135MP0003828_pulmonary_edema0.53540332
136MP0002114_abnormal_axial_skeleton0.53538162
137MP0005167_abnormal_blood-brain_barrier0.52094407
138MP0004043_abnormal_pH_regulation0.51820693
139MP0005386_behavior/neurological_phenoty0.51298181
140MP0004924_abnormal_behavior0.51298181
141MP0001943_abnormal_respiration0.48274631
142MP0009250_abnormal_appendicular_skeleto0.47287847
143MP0002752_abnormal_somatic_nervous0.44397526
144MP0002078_abnormal_glucose_homeostasis0.42122185
145MP0000762_abnormal_tongue_morphology0.41166982
146MP0009672_abnormal_birth_weight0.40761126

Predicted human phenotypes

RankGene SetZ-score
1Centrally nucleated skeletal muscle fibers (HP:0003687)4.51156003
2Myoglobinuria (HP:0002913)4.47790824
3Rhabdomyolysis (HP:0003201)4.39213963
4Subaortic stenosis (HP:0001682)4.19066438
5Abnormality of the left ventricular outflow tract (HP:0011103)4.19066438
6Myopathic facies (HP:0002058)4.16891685
7Gonadal dysgenesis (HP:0000133)4.12069678
8Sex reversal (HP:0012245)4.09555144
9Abnormal sex determination (HP:0012244)4.09555144
10Type 1 muscle fiber predominance (HP:0003803)4.06874713
11Neck muscle weakness (HP:0000467)3.99967054
12Exercise-induced myalgia (HP:0003738)3.99047626
13Muscle fiber inclusion bodies (HP:0100299)3.86987659
14Male infertility (HP:0003251)3.76418300
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67963855
16Sudden death (HP:0001699)3.65912803
17Hyperacusis (HP:0010780)3.48294691
18Nemaline bodies (HP:0003798)3.41729977
19Frequent falls (HP:0002359)3.41323015
20Ankle clonus (HP:0011448)3.39915570
21Difficulty running (HP:0009046)3.38174692
22Asymmetric septal hypertrophy (HP:0001670)3.29582003
23Distal lower limb muscle weakness (HP:0009053)3.28102510
24Testicular neoplasm (HP:0010788)3.26435960
25EMG: neuropathic changes (HP:0003445)3.21751103
26Abnormality of the lower motor neuron (HP:0002366)3.16275997
27Malignant hyperthermia (HP:0002047)3.11761596
28Bundle branch block (HP:0011710)3.10976695
29Renovascular hypertension (HP:0100817)3.03753242
30Insomnia (HP:0100785)3.02361640
31Areflexia of lower limbs (HP:0002522)2.96233637
32Renal duplication (HP:0000075)2.93841058
33Elfin facies (HP:0004428)2.90522622
34Distal arthrogryposis (HP:0005684)2.81410919
35Generalized muscle weakness (HP:0003324)2.80360204
36Exercise-induced muscle cramps (HP:0003710)2.74398762
37Overriding aorta (HP:0002623)2.73598201
38Hyporeflexia of lower limbs (HP:0002600)2.72952296
39Increased variability in muscle fiber diameter (HP:0003557)2.71142900
40Termporal pattern (HP:0011008)2.69225663
41Insidious onset (HP:0003587)2.69225663
42Shoulder girdle muscle weakness (HP:0003547)2.64232977
43Abnormality of skeletal muscle fiber size (HP:0012084)2.60815064
44Germ cell neoplasia (HP:0100728)2.58960684
45Muscle hypertrophy of the lower extremities (HP:0008968)2.58214940
46Distal lower limb amyotrophy (HP:0008944)2.55422312
47Hand muscle atrophy (HP:0009130)2.55345406
48Round ear (HP:0100830)2.55231777
49Flat cornea (HP:0007720)2.52326170
50Bladder diverticulum (HP:0000015)2.51953533
51Ventricular tachycardia (HP:0004756)2.51649060
52Bulbar palsy (HP:0001283)2.48432409
53Slender build (HP:0001533)2.47277052
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44309182
55Short 4th metacarpal (HP:0010044)2.44309182
56Dilated cardiomyopathy (HP:0001644)2.44118470
57Scapular winging (HP:0003691)2.42580243
58Hip contracture (HP:0003273)2.38338465
59Weak cry (HP:0001612)2.36270060
60Neoplasm of the heart (HP:0100544)2.33203714
61Male pseudohermaphroditism (HP:0000037)2.31865559
62Hypoventilation (HP:0002791)2.31454223
63Amyotrophic lateral sclerosis (HP:0007354)2.28860305
64Calf muscle hypertrophy (HP:0008981)2.27989781
65Pelvic girdle muscle weakness (HP:0003749)2.25086039
66Upper limb amyotrophy (HP:0009129)2.24777631
67Distal upper limb amyotrophy (HP:0007149)2.24777631
68Spinal rigidity (HP:0003306)2.24603531
69Hyperkalemia (HP:0002153)2.24526948
70Limb-girdle muscle atrophy (HP:0003797)2.24506823
71Gowers sign (HP:0003391)2.22549438
72Calcaneovalgus deformity (HP:0001848)2.21917085
73Myokymia (HP:0002411)2.21039924
74Lipoatrophy (HP:0100578)2.20345349
75Pointed chin (HP:0000307)2.18528321
76Abnormality of the foot musculature (HP:0001436)2.18417676
77Fatigable weakness (HP:0003473)2.16046054
78Abnormality of the neuromuscular junction (HP:0003398)2.16046054
79Heart block (HP:0012722)2.15735390
80Myotonia (HP:0002486)2.15013808
81Wrist flexion contracture (HP:0001239)2.12811121
82Waddling gait (HP:0002515)2.11903413
83Limb-girdle muscle weakness (HP:0003325)2.10116696
84Abnormality of the musculature of the pelvis (HP:0001469)2.09750276
85Abnormality of the hip-girdle musculature (HP:0001445)2.09750276
86Ulnar deviation of the wrist (HP:0003049)2.08641732
87Abnormality of the vocal cords (HP:0008777)2.08438582
88High anterior hairline (HP:0009890)2.06812103
89Lymphangioma (HP:0100764)2.04722445
90Supranuclear gaze palsy (HP:0000605)2.03718904
91Urinary urgency (HP:0000012)2.03028672
92Abnormality of the calcaneus (HP:0008364)2.01401509
93Difficulty climbing stairs (HP:0003551)2.00748177
94Increased connective tissue (HP:0009025)2.00467929
95Abnormal atrioventricular conduction (HP:0005150)1.99858697
96Foot dorsiflexor weakness (HP:0009027)1.99793876
97Ankle contracture (HP:0006466)1.99777843
98Abnormality of the 4th metacarpal (HP:0010012)1.99272725
99Deformed tarsal bones (HP:0008119)1.99160452
100Proximal amyotrophy (HP:0007126)1.98402772
101Progressive muscle weakness (HP:0003323)1.95517656
102Abnormality of the shoulder girdle musculature (HP:0001435)1.95170431
103Abnormal eating behavior (HP:0100738)1.95071869
104Shallow orbits (HP:0000586)1.92499462
105Muscle fiber splitting (HP:0003555)1.91119165
106Amblyopia (HP:0000646)1.90740383
107Muscular dystrophy (HP:0003560)1.90373316
108Gonadotropin excess (HP:0000837)1.90326009
109Fetal akinesia sequence (HP:0001989)1.90267924
110Focal seizures (HP:0007359)1.89942805
111Abnormality of the diencephalon (HP:0010662)1.89838607
112Facial diplegia (HP:0001349)1.89757912
113Adducted thumb (HP:0001181)1.88108933
114Abnormality of the calf musculature (HP:0001430)1.87789362
115Lower limb amyotrophy (HP:0007210)1.87069033
116Absent phalangeal crease (HP:0006109)1.85911525
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85514098
118Abnormality of the astrocytes (HP:0100707)1.84908297
119Astrocytoma (HP:0009592)1.84908297
120Mildly elevated creatine phosphokinase (HP:0008180)1.83084938
121Muscle stiffness (HP:0003552)1.82589545
122Bowel diverticulosis (HP:0005222)1.82534662
123Action tremor (HP:0002345)1.79008184
124Abnormal finger flexion creases (HP:0006143)1.78445721
125Nonprogressive disorder (HP:0003680)1.76808859
126Pachygyria (HP:0001302)1.75157433
127Sacral dimple (HP:0000960)1.74934892
128EMG: myopathic abnormalities (HP:0003458)1.73964374
129Stridor (HP:0010307)1.73481292
130Abnormality of the corticospinal tract (HP:0002492)1.73009868
131Urinary bladder sphincter dysfunction (HP:0002839)1.72109915
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71677263
133Hypoplasia of the brainstem (HP:0002365)1.71677263
134Abnormality of male internal genitalia (HP:0000022)1.71419010
135Rectal prolapse (HP:0002035)1.70226487
136Bronchomalacia (HP:0002780)1.69997716
137Limited hip movement (HP:0008800)1.69850698
138Ventricular arrhythmia (HP:0004308)1.69644850
139Rimmed vacuoles (HP:0003805)1.69087617
140Respiratory insufficiency due to muscle weakness (HP:0002747)1.68168444
141Long clavicles (HP:0000890)1.67582056
142Failure to thrive in infancy (HP:0001531)1.67328021
143Patellar dislocation (HP:0002999)1.67192955
144Metatarsus adductus (HP:0001840)1.66185227
145Ragged-red muscle fibers (HP:0003200)1.61399781
146Ulnar deviation of finger (HP:0009465)1.50715748
147Short palpebral fissure (HP:0012745)1.44283007
148Exercise intolerance (HP:0003546)1.41708564
149Steppage gait (HP:0003376)1.41383488
150Popliteal pterygium (HP:0009756)1.41096439
151Congenital hip dislocation (HP:0001374)1.39319468
152Atrial fibrillation (HP:0005110)1.38457048
153Oligomenorrhea (HP:0000876)1.37840536
154Hypoplastic ischia (HP:0003175)1.36424581
155Atrioventricular block (HP:0001678)1.36005986
156Prolonged QT interval (HP:0001657)1.34969025
157Paralysis (HP:0003470)1.34181297
158Type 2 muscle fiber atrophy (HP:0003554)1.33051640
159Abnormality of the ischium (HP:0003174)1.32626583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.46408201
2TYRO33.09585289
3ICK2.95684923
4PHKG22.88231848
5PHKG12.88231848
6RIPK12.85154331
7EPHA32.42213341
8MAP3K42.41379756
9TRIB32.39694667
10PAK62.27492404
11PIK3CG2.11915722
12TTN2.05785740
13MAP3K91.97413096
14PRKD31.95079201
15CDK121.87051026
16PINK11.81204486
17BRD41.80458869
18OBSCN1.79692866
19LATS21.75129981
20EPHB21.74842313
21KSR11.73070918
22SIK21.72148370
23NTRK21.67947313
24MINK11.56362485
25MUSK1.56163395
26MAP3K101.52702809
27DAPK21.52161093
28DYRK21.41431784
29NTRK31.39002586
30PDGFRA1.35253966
31KSR21.34900216
32MAP2K31.34265134
33ERBB21.32466822
34EEF2K1.31467415
35MAP2K41.28130349
36CAMK1G1.19386961
37PKN21.18456686
38UHMK11.18321444
39MAPK131.18273694
40ERBB31.14827391
41RPS6KA21.14376080
42NME11.12129406
43PTK61.06176781
44NEK11.02862479
45WNK30.99398767
46LIMK10.99379007
47DMPK0.96757014
48PAK30.96751631
49MAPKAPK30.93728769
50MAP2K70.90220643
51SIK10.87666111
52CDK50.86833129
53TIE10.85383235
54CAMK2G0.85239289
55CAMK1D0.82430702
56CSNK1G20.82116272
57DDR20.81792830
58TRPM70.78955179
59MTOR0.78580634
60CSNK1A1L0.75790802
61PKN10.74818211
62MARK20.74026973
63SGK30.73434341
64RET0.73154119
65PNCK0.70491400
66CAMK10.70317964
67MOS0.70082155
68ROCK10.70003314
69PAK20.69850713
70PRKAA20.68263573
71MAP3K70.68220504
72IRAK20.67927105
73DYRK1A0.67698639
74CAMKK10.64910279
75FGFR20.64132171
76ALK0.63473566
77CCNB10.63304640
78SGK20.63100580
79STK110.62598673
80LMTK20.62187626
81FGFR10.60666111
82LATS10.59543850
83CDC42BPA0.59356245
84MAPK120.58068363
85CSNK1G30.58051467
86PRKG10.56900947
87CDK150.56394229
88CDK180.55732710
89CAMK2A0.55552108
90MAPK70.55148396
91CAMK2B0.54771253
92AKT20.54765186
93CAMK2D0.54713168
94PRKCZ0.53192045
95MAPK40.52968320
96CDK140.51611710
97BMX0.51392844
98MAPK90.50885978
99TAOK10.50181177
100NTRK10.49731484
101CDK11A0.49077280
102RPS6KA10.47709271
103CDK190.47039143
104PRKAA10.47035890
105DYRK1B0.46378263
106MAP2K60.45947743
107ILK0.45134253
108CAMK40.44876494
109BCKDK0.44237408
110RPS6KC10.44153159
111RPS6KL10.44153159
112WNK10.43296892
113PAK40.43261803
114PTK20.43221685
115CASK0.42769380
116PDK30.41832399
117PDK40.41832399
118STK380.41812989
119SGK4940.41512060
120SGK2230.41512060
121ROCK20.41192467
122MAPK100.41050049
123MAP3K60.40547186
124RPS6KA30.40419461
125PRKACA0.40254365
126PRKCG0.38473712
127DAPK10.37634096
128RPS6KA60.37178147
129MAPK80.36412258
130GSK3B0.35539152
131PIK3CA0.35443311
132SGK10.35268242
133MAP2K10.34500834
134MAPK110.33878069
135PDK20.28508426
136PRKD10.26238777
137PRPF4B0.25552443
138RPS6KB10.25067804
139PRKACB0.24493321
140EPHA40.23013224
141PRKCH0.22592715
142PDPK10.21621598
143MAP3K110.20828848
144TNIK0.20487211
145PRKACG0.20065325

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43700576
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.24854742
3* Axon guidance_Homo sapiens_hsa043602.59767384
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27321366
5Basal cell carcinoma_Homo sapiens_hsa052171.96877648
6Hedgehog signaling pathway_Homo sapiens_hsa043401.90409250
7Arginine and proline metabolism_Homo sapiens_hsa003301.85033222
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79028124
9Arginine biosynthesis_Homo sapiens_hsa002201.76484709
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75505447
11Oxytocin signaling pathway_Homo sapiens_hsa049211.68101927
12Endometrial cancer_Homo sapiens_hsa052131.66768598
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66394538
14Dilated cardiomyopathy_Homo sapiens_hsa054141.62568254
15Circadian entrainment_Homo sapiens_hsa047131.58506840
16Carbon metabolism_Homo sapiens_hsa012001.57443415
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56525825
18Nicotine addiction_Homo sapiens_hsa050331.51714155
19Long-term potentiation_Homo sapiens_hsa047201.49393818
20Notch signaling pathway_Homo sapiens_hsa043301.48792960
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48121053
22Hippo signaling pathway_Homo sapiens_hsa043901.47150229
23Gap junction_Homo sapiens_hsa045401.46057299
24Dorso-ventral axis formation_Homo sapiens_hsa043201.45660286
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45130791
26Dopaminergic synapse_Homo sapiens_hsa047281.43497836
27Gastric acid secretion_Homo sapiens_hsa049711.42004879
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39764212
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34282531
30Renin secretion_Homo sapiens_hsa049241.33624354
31GABAergic synapse_Homo sapiens_hsa047271.32155549
32Glutamatergic synapse_Homo sapiens_hsa047241.30330391
33Colorectal cancer_Homo sapiens_hsa052101.29706625
34GnRH signaling pathway_Homo sapiens_hsa049121.28712292
35Glioma_Homo sapiens_hsa052141.28673115
36Cardiac muscle contraction_Homo sapiens_hsa042601.28592504
37mTOR signaling pathway_Homo sapiens_hsa041501.26879603
38Estrogen signaling pathway_Homo sapiens_hsa049151.25853296
39mRNA surveillance pathway_Homo sapiens_hsa030151.24616805
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23235796
41ErbB signaling pathway_Homo sapiens_hsa040121.22824973
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22322889
43VEGF signaling pathway_Homo sapiens_hsa043701.22244647
44Viral myocarditis_Homo sapiens_hsa054161.21524724
45Focal adhesion_Homo sapiens_hsa045101.21309669
46Insulin signaling pathway_Homo sapiens_hsa049101.21015207
47Fructose and mannose metabolism_Homo sapiens_hsa000511.20653806
48Synaptic vesicle cycle_Homo sapiens_hsa047211.20480588
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19948145
50Melanogenesis_Homo sapiens_hsa049161.19786797
51Alzheimers disease_Homo sapiens_hsa050101.19776723
52Cholinergic synapse_Homo sapiens_hsa047251.19551430
53Tight junction_Homo sapiens_hsa045301.19448758
54Pentose phosphate pathway_Homo sapiens_hsa000301.18901561
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16656488
56Wnt signaling pathway_Homo sapiens_hsa043101.15130243
57Type II diabetes mellitus_Homo sapiens_hsa049301.12876682
58Parkinsons disease_Homo sapiens_hsa050121.12204908
59cAMP signaling pathway_Homo sapiens_hsa040241.11456902
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.11296286
61Olfactory transduction_Homo sapiens_hsa047401.10890790
62Oocyte meiosis_Homo sapiens_hsa041141.10619468
63Pyruvate metabolism_Homo sapiens_hsa006201.10557677
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10350760
65Salivary secretion_Homo sapiens_hsa049701.08844603
66Fatty acid degradation_Homo sapiens_hsa000711.07956464
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06544532
68Amphetamine addiction_Homo sapiens_hsa050311.06235144
69ECM-receptor interaction_Homo sapiens_hsa045121.05577532
70Renal cell carcinoma_Homo sapiens_hsa052111.05023514
71Central carbon metabolism in cancer_Homo sapiens_hsa052301.04296365
72Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03734163
73Biosynthesis of amino acids_Homo sapiens_hsa012301.02779384
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02004764
75Morphine addiction_Homo sapiens_hsa050321.01515159
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99615281
77Long-term depression_Homo sapiens_hsa047300.98632563
78Insulin secretion_Homo sapiens_hsa049110.97968768
79Amoebiasis_Homo sapiens_hsa051460.97778494
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97552637
81Calcium signaling pathway_Homo sapiens_hsa040200.97409895
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97012218
83Lysine degradation_Homo sapiens_hsa003100.93847641
84Fatty acid biosynthesis_Homo sapiens_hsa000610.93698034
85AMPK signaling pathway_Homo sapiens_hsa041520.93483006
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93332970
87Cocaine addiction_Homo sapiens_hsa050300.93177779
88Proteoglycans in cancer_Homo sapiens_hsa052050.92320143
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91909418
90Glucagon signaling pathway_Homo sapiens_hsa049220.90402634
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89841643
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89494841
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89360134
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88480960
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.87948674
96Starch and sucrose metabolism_Homo sapiens_hsa005000.87105181
97Phenylalanine metabolism_Homo sapiens_hsa003600.86782301
98Non-small cell lung cancer_Homo sapiens_hsa052230.86472020
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.86396383
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.84545846
101Insulin resistance_Homo sapiens_hsa049310.84464151
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81723258
103MAPK signaling pathway_Homo sapiens_hsa040100.81516490
104Choline metabolism in cancer_Homo sapiens_hsa052310.79032220
105Chronic myeloid leukemia_Homo sapiens_hsa052200.77489286
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77350802
107Propanoate metabolism_Homo sapiens_hsa006400.77330203
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77329512
109Oxidative phosphorylation_Homo sapiens_hsa001900.77152394
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76271396
111Fatty acid metabolism_Homo sapiens_hsa012120.74599961
112TGF-beta signaling pathway_Homo sapiens_hsa043500.74349325
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73158307
114MicroRNAs in cancer_Homo sapiens_hsa052060.72971371
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71568040
116Small cell lung cancer_Homo sapiens_hsa052220.67732104
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67709130
118Prolactin signaling pathway_Homo sapiens_hsa049170.67186149
119Adherens junction_Homo sapiens_hsa045200.66149197
120Protein digestion and absorption_Homo sapiens_hsa049740.65825915
121Circadian rhythm_Homo sapiens_hsa047100.62918586
122Rap1 signaling pathway_Homo sapiens_hsa040150.62862156
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61134768
124Pathways in cancer_Homo sapiens_hsa052000.60581374
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59412258
126Nitrogen metabolism_Homo sapiens_hsa009100.58439582
127Taste transduction_Homo sapiens_hsa047420.57982261
128Alcoholism_Homo sapiens_hsa050340.57764281
129Bile secretion_Homo sapiens_hsa049760.56484192
130PPAR signaling pathway_Homo sapiens_hsa033200.52188466
131Butanoate metabolism_Homo sapiens_hsa006500.49823729
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47915420
133Huntingtons disease_Homo sapiens_hsa050160.45030355
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41763624
135Sulfur relay system_Homo sapiens_hsa041220.41471213
136FoxO signaling pathway_Homo sapiens_hsa040680.38023477
137Ovarian steroidogenesis_Homo sapiens_hsa049130.37207501
138Serotonergic synapse_Homo sapiens_hsa047260.36363071
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35667603
140Galactose metabolism_Homo sapiens_hsa000520.34113348
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33344371

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