SEMA4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52393302
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52393302
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.52393302
4modulation by symbiont of host immune response (GO:0052553)5.52393302
5positive regulation by symbiont of host defense response (GO:0052509)5.52393302
6modulation by symbiont of host defense response (GO:0052031)5.52393302
7positive regulation of gamma-delta T cell activation (GO:0046645)5.42338026
8regulation of B cell receptor signaling pathway (GO:0050855)4.44020693
9negative regulation of lymphocyte mediated immunity (GO:0002707)4.41502244
10activated T cell proliferation (GO:0050798)4.39165209
11negative regulation of T cell mediated immunity (GO:0002710)4.32149920
12negative regulation of cell killing (GO:0031342)4.30008768
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30008768
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28804233
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28804233
16detection of other organism (GO:0098543)4.22026905
17antigen processing and presentation of endogenous antigen (GO:0019883)4.17364824
18neutrophil activation involved in immune response (GO:0002283)4.15784454
19detection of bacterium (GO:0016045)4.11129063
20T cell migration (GO:0072678)4.01175307
21tolerance induction (GO:0002507)3.94975335
22negative regulation of leukocyte mediated immunity (GO:0002704)3.91512855
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89391020
24regulation of interferon-beta biosynthetic process (GO:0045357)3.88692319
25regulation of gamma-delta T cell activation (GO:0046643)3.83858069
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80647436
27regulation of gamma-delta T cell differentiation (GO:0045586)3.79172548
28B cell receptor signaling pathway (GO:0050853)3.72296546
29negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.70602866
30respiratory burst (GO:0045730)3.66451944
31macrophage activation involved in immune response (GO:0002281)3.61333428
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57663857
33response to host immune response (GO:0052572)3.57663857
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57649203
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54902166
36negative T cell selection (GO:0043383)3.54876286
37positive regulation of granulocyte differentiation (GO:0030854)3.52658098
38negative thymic T cell selection (GO:0045060)3.50048110
39regulation of T cell tolerance induction (GO:0002664)3.49703701
40immunoglobulin mediated immune response (GO:0016064)3.48228936
41response to peptidoglycan (GO:0032494)3.48224670
42detection of external biotic stimulus (GO:0098581)3.48042316
43positive regulation of interleukin-17 production (GO:0032740)3.46988565
44response to muramyl dipeptide (GO:0032495)3.43389084
45positive regulation of antigen processing and presentation (GO:0002579)3.42864325
46positive thymic T cell selection (GO:0045059)3.42702017
47regulation of natural killer cell mediated immunity (GO:0002715)3.34519451
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.34519451
49* leukocyte aggregation (GO:0070486)3.33317373
50antigen processing and presentation via MHC class Ib (GO:0002475)3.32565961
51myeloid cell activation involved in immune response (GO:0002275)3.31844261
52regulation of interferon-alpha production (GO:0032647)3.31592095
53neutrophil activation (GO:0042119)3.29227875
54regulation of tolerance induction (GO:0002643)3.28562214
55positive regulation of B cell differentiation (GO:0045579)3.28420583
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28404828
57response to host (GO:0075136)3.28404828
58response to host defenses (GO:0052200)3.28404828
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27956586
60positive regulation of interferon-alpha production (GO:0032727)3.26097637
61mast cell activation (GO:0045576)3.24711425
62negative regulation of erythrocyte differentiation (GO:0045647)3.22388321
63regulation of B cell differentiation (GO:0045577)3.22107873
64negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.21831988
65granulocyte activation (GO:0036230)3.20696481
66regulation of regulatory T cell differentiation (GO:0045589)3.20024545
67detection of molecule of bacterial origin (GO:0032490)3.18263431
68regulation of T cell mediated cytotoxicity (GO:0001914)3.17712210
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16910682
70negative regulation of T-helper cell differentiation (GO:0045623)3.16910682
71response to interleukin-15 (GO:0070672)3.16871301
72negative regulation of interleukin-12 production (GO:0032695)3.15289129
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06955367
74regulation of interleukin-12 biosynthetic process (GO:0045075)3.06701477
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04832094
76antigen receptor-mediated signaling pathway (GO:0050851)3.04708593
77detection of biotic stimulus (GO:0009595)3.03790377
78B cell homeostasis (GO:0001782)3.03719794
79positive regulation of interleukin-2 production (GO:0032743)3.02633787
80interferon-gamma production (GO:0032609)3.02456320
81regulation of alpha-beta T cell proliferation (GO:0046640)3.00746524
82cellular response to interleukin-15 (GO:0071350)3.00679936
83leukocyte migration involved in inflammatory response (GO:0002523)3.00359186
84microglial cell activation (GO:0001774)3.00120986
85positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99660185
86macrophage activation (GO:0042116)2.98969979
87regulation of interleukin-2 biosynthetic process (GO:0045076)2.98640987
88negative regulation of adaptive immune response (GO:0002820)2.98244328
89neutrophil mediated immunity (GO:0002446)2.97329983
90defense response to protozoan (GO:0042832)2.95874333
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95675974
92regulation of interleukin-17 production (GO:0032660)2.94302094
93positive regulation of tolerance induction (GO:0002645)2.94147074
94positive T cell selection (GO:0043368)2.92374874
95negative regulation of alpha-beta T cell activation (GO:0046636)2.91893792
96cellular extravasation (GO:0045123)2.90896671
97germinal center formation (GO:0002467)2.90852149
98thymic T cell selection (GO:0045061)2.89812820
99regulation of antigen processing and presentation (GO:0002577)2.89584713
100regulation of mast cell degranulation (GO:0043304)2.87985379
101T cell receptor signaling pathway (GO:0050852)2.87910093
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87525908
103negative regulation of B cell proliferation (GO:0030889)2.86396193
104regulation of chronic inflammatory response (GO:0002676)2.86174254
105T cell selection (GO:0045058)2.85676889
106NIK/NF-kappaB signaling (GO:0038061)2.85248249
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85202731
108* leukocyte cell-cell adhesion (GO:0007159)2.84995476
109modulation by symbiont of host cellular process (GO:0044068)2.84096271
110T cell proliferation (GO:0042098)2.83206702
111myeloid dendritic cell activation (GO:0001773)2.82347368
112T cell costimulation (GO:0031295)2.82316486
113positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82172854
114positive regulation of mast cell activation (GO:0033005)2.79655048
115myeloid dendritic cell differentiation (GO:0043011)2.79528590
116cellular response to type I interferon (GO:0071357)2.78429257
117type I interferon signaling pathway (GO:0060337)2.78429257
118response to type I interferon (GO:0034340)2.78241970
119heterotypic cell-cell adhesion (GO:0034113)2.78148297
120lymphocyte costimulation (GO:0031294)2.77583886
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77177104
122leukocyte degranulation (GO:0043299)2.77121569
123response to lipoprotein particle (GO:0055094)2.76932112
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76816295
125negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.76717293
126response to protozoan (GO:0001562)2.76537531
127Rap protein signal transduction (GO:0032486)2.74035770
128positive regulation of cytokine biosynthetic process (GO:0042108)2.72661049
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71781259
130interferon-gamma-mediated signaling pathway (GO:0060333)2.71422643
131regulation of isotype switching to IgG isotypes (GO:0048302)2.71415348
132T cell homeostasis (GO:0043029)2.69743484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.00223035
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.44300000
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.04540170
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.54544109
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.25306397
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.86576338
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79550069
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74239674
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66309808
10RUNX_20019798_ChIP-Seq_JUKART_Human3.33015407
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28943980
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19700690
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03792368
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.99757335
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.94401839
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93531321
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93442335
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.70529311
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62190172
20* MYB_26560356_Chip-Seq_TH2_Human2.55452282
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51223579
22VDR_21846776_ChIP-Seq_THP-1_Human2.46460012
23SPI1_23127762_ChIP-Seq_K562_Human2.35526215
24* MAF_26560356_Chip-Seq_TH1_Human2.35014944
25MYC_22102868_ChIP-Seq_BL_Human2.34163112
26* SCL_19346495_ChIP-Seq_HPC-7_Human2.31612032
27* VDR_24763502_ChIP-Seq_THP-1_Human2.25875993
28SPI1_23547873_ChIP-Seq_NB4_Human2.24130241
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13753133
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08812654
31MYB_26560356_Chip-Seq_TH1_Human2.08664501
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.06717995
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06294181
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97253923
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93999255
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.92998798
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90052635
38* UTX_26944678_Chip-Seq_JUKART_Human1.89978423
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81019132
40* GATA3_27048872_Chip-Seq_THYMUS_Human1.76882001
41TCF7_22412390_ChIP-Seq_EML_Mouse1.69152453
42* PU_27001747_Chip-Seq_BMDM_Mouse1.62258629
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60052534
44* KDM2B_26808549_Chip-Seq_DND41_Human1.54562133
45* VDR_24787735_ChIP-Seq_THP-1_Human1.54074600
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52000804
47MAF_26560356_Chip-Seq_TH2_Human1.49631835
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47472886
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43633662
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41031532
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40040192
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38477369
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34951422
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31777810
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28788535
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28482810
57* GATA3_26560356_Chip-Seq_TH2_Human1.27317128
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24476089
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23005914
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.17642219
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17420481
62GATA1_19941826_ChIP-Seq_K562_Human1.17179482
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16894475
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14486967
65* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13526628
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12439324
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11302271
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.10455846
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.10030609
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09981608
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07453522
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07446815
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.07420160
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07030220
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06611306
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05142722
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04679445
78* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03016568
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00540847
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00092245
81CIITA_25753668_ChIP-Seq_RAJI_Human0.98833963
82* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97830561
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95820712
84GATA2_19941826_ChIP-Seq_K562_Human0.95279026
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95052885
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93816883
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93089466
88BCL6_27268052_Chip-Seq_Bcells_Human0.90271436
89BCOR_27268052_Chip-Seq_Bcells_Human0.90167141
90DROSHA_22980978_ChIP-Seq_HELA_Human0.87646443
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.86914825
92SMRT_27268052_Chip-Seq_Bcells_Human0.86596021
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86233154
94E2F7_22180533_ChIP-Seq_HELA_Human0.84725235
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83921216
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82438090
97NCOR1_26117541_ChIP-Seq_K562_Human0.80455974
98TFEB_21752829_ChIP-Seq_HELA_Human0.76018801
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74081847
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.72753442
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67641572
102SPI1_20517297_ChIP-Seq_HL60_Human0.66244137
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65956905
104STAT1_20625510_ChIP-Seq_HELA_Human0.62835697
105EGR1_19032775_ChIP-ChIP_M12_Human0.58831932
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.58609133
107GATA1_22025678_ChIP-Seq_K562_Human0.58275316
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.57878744
109LXR_22292898_ChIP-Seq_THP-1_Human0.57628072
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56639184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.92376988
2MP0005671_abnormal_response_to3.41888627
3MP0005387_immune_system_phenotype3.39002718
4MP0001790_abnormal_immune_system3.39002718
5MP0003303_peritoneal_inflammation3.28135203
6MP0006082_CNS_inflammation3.24867921
7MP0005000_abnormal_immune_tolerance3.22557396
8* MP0001800_abnormal_humoral_immune3.15061989
9MP0009785_altered_susceptibility_to2.98954580
10MP0000685_abnormal_immune_system2.97422168
11* MP0002452_abnormal_antigen_presenting2.86875533
12MP0003436_decreased_susceptibility_to2.85839933
13* MP0002723_abnormal_immune_serum2.81326769
14MP0002419_abnormal_innate_immunity2.81084755
15MP0005058_abnormal_lysosome_morphology2.80758393
16MP0005025_abnormal_response_to2.72631732
17* MP0002420_abnormal_adaptive_immunity2.63940517
18MP0004510_myositis2.63607876
19* MP0001819_abnormal_immune_cell2.61998846
20MP0002148_abnormal_hypersensitivity_rea2.55270657
21MP0003172_abnormal_lysosome_physiology2.51639402
22MP0003763_abnormal_thymus_physiology2.46205588
23MP0003300_gastrointestinal_ulcer2.36121952
24MP0005310_abnormal_salivary_gland2.21490113
25MP0004947_skin_inflammation2.20384228
26* MP0002398_abnormal_bone_marrow2.19837396
27MP0000920_abnormal_myelination2.13577152
28MP0009333_abnormal_splenocyte_physiolog2.11663601
29* MP0000716_abnormal_immune_system2.11505112
30MP0002405_respiratory_system_inflammati2.10467622
31MP0005464_abnormal_platelet_physiology2.06704119
32MP0003690_abnormal_glial_cell1.92651314
33MP0009278_abnormal_bone_marrow1.86074020
34* MP0000689_abnormal_spleen_morphology1.84319010
35MP0003724_increased_susceptibility_to1.78760613
36MP0002722_abnormal_immune_system1.75801749
37MP0001845_abnormal_inflammatory_respons1.73734556
38MP0010155_abnormal_intestine_physiology1.73501489
39* MP0002429_abnormal_blood_cell1.67118769
40MP0001533_abnormal_skeleton_physiology1.56592321
41MP0002933_joint_inflammation1.56474810
42MP0001873_stomach_inflammation1.51272590
43MP0000604_amyloidosis1.50925043
44MP0000703_abnormal_thymus_morphology1.48262636
45MP0001851_eye_inflammation1.47212332
46MP0002396_abnormal_hematopoietic_system1.44417462
47MP0003448_altered_tumor_morphology1.42844255
48MP0003866_abnormal_defecation1.42130066
49MP0001853_heart_inflammation1.39078119
50MP0002132_abnormal_respiratory_system1.38262913
51MP0000465_gastrointestinal_hemorrhage1.37721730
52MP0002166_altered_tumor_susceptibility1.32927093
53MP0003183_abnormal_peptide_metabolism1.32726574
54MP0000569_abnormal_digit_pigmentation1.26716511
55MP0008469_abnormal_protein_level1.24233914
56MP0005174_abnormal_tail_pigmentation1.23187176
57MP0002998_abnormal_bone_remodeling1.18513351
58MP0002006_tumorigenesis1.16840043
59MP0004883_abnormal_blood_vessel1.11686781
60MP0000343_altered_response_to1.10097635
61MP0005397_hematopoietic_system_phenotyp1.02099158
62MP0001545_abnormal_hematopoietic_system1.02099158
63MP0000015_abnormal_ear_pigmentation1.00455976
64MP0009764_decreased_sensitivity_to0.99537596
65MP0004808_abnormal_hematopoietic_stem0.95327316
66MP0002009_preneoplasia0.94465842
67MP0003075_altered_response_to0.94143750
68MP0004130_abnormal_muscle_cell0.93300892
69MP0000858_altered_metastatic_potential0.88611798
70MP0003634_abnormal_glial_cell0.86928474
71MP0001986_abnormal_taste_sensitivity0.86447098
72MP0000383_abnormal_hair_follicle0.84874911
73MP0003453_abnormal_keratinocyte_physiol0.80466618
74MP0002138_abnormal_hepatobiliary_system0.77809740
75MP0010307_abnormal_tumor_latency0.75332969
76MP0005166_decreased_susceptibility_to0.74289164
77MP0003045_fibrosis0.74102973
78MP0003329_amyloid_beta_deposits0.73255470
79MP0008004_abnormal_stomach_pH0.72428011
80MP0008874_decreased_physiological_sensi0.71000510
81MP0003191_abnormal_cellular_cholesterol0.70771209
82MP0004742_abnormal_vestibular_system0.70573297
83MP0008057_abnormal_DNA_replication0.70439423
84MP0004381_abnormal_hair_follicle0.69283613
85MP0000490_abnormal_crypts_of0.67938719
86MP0005075_abnormal_melanosome_morpholog0.66766931
87MP0009840_abnormal_foam_cell0.66545074
88MP0008569_lethality_at_weaning0.63836404
89MP0005451_abnormal_body_composition0.62366200
90MP0009763_increased_sensitivity_to0.61332721
91MP0004185_abnormal_adipocyte_glucose0.60803156
92MP0003656_abnormal_erythrocyte_physiolo0.60135059
93MP0008260_abnormal_autophagy0.59550779
94MP0003795_abnormal_bone_structure0.59163887
95MP0003787_abnormal_imprinting0.58777162
96MP0005164_abnormal_response_to0.57408684
97MP0009765_abnormal_xenobiotic_induced0.56338973
98MP0005390_skeleton_phenotype0.56184605
99MP0002693_abnormal_pancreas_physiology0.56015586
100MP0003091_abnormal_cell_migration0.55556462
101MP0001348_abnormal_lacrimal_gland0.55357286
102MP0002277_abnormal_respiratory_mucosa0.55277490
103MP0005076_abnormal_cell_differentiation0.54680438
104MP0003566_abnormal_cell_adhesion0.52701305
105MP0001663_abnormal_digestive_system0.52432796
106MP0002332_abnormal_exercise_endurance0.52113995
107MP0008961_abnormal_basal_metabolism0.51566706
108MP0000249_abnormal_blood_vessel0.50944013
109MP0002019_abnormal_tumor_incidence0.50687695
110MP0010678_abnormal_skin_adnexa0.49535941
111MP0005535_abnormal_body_temperature0.49513026
112MP0005167_abnormal_blood-brain_barrier0.49045929
113MP0008873_increased_physiological_sensi0.48651404
114MP0003221_abnormal_cardiomyocyte_apopto0.46554968
115MP0004484_altered_response_of0.46390383
116MP0003632_abnormal_nervous_system0.46364151
117MP0003828_pulmonary_edema0.43183747
118MP0000371_diluted_coat_color0.42598020

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.78078530
2Stomatitis (HP:0010280)5.16719530
3Eczematoid dermatitis (HP:0000976)4.95210370
4Recurrent bacterial skin infections (HP:0005406)4.89090978
5Elevated erythrocyte sedimentation rate (HP:0003565)4.70538261
6Increased cerebral lipofuscin (HP:0011813)4.45127059
7Abnormality of macrophages (HP:0004311)4.28444620
8Myositis (HP:0100614)4.15776625
9Chronic otitis media (HP:0000389)4.12944420
10Recurrent fungal infections (HP:0002841)4.10216358
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.08967813
12Recurrent viral infections (HP:0004429)4.06359455
13Gastrointestinal infarctions (HP:0005244)3.92154283
14Optic neuritis (HP:0100653)3.91685254
15Retrobulbar optic neuritis (HP:0100654)3.91685254
16T lymphocytopenia (HP:0005403)3.86801249
17Abnormality of T cell number (HP:0011839)3.78046742
18Recurrent skin infections (HP:0001581)3.78002008
19Obstructive lung disease (HP:0006536)3.71909273
20Chronic obstructive pulmonary disease (HP:0006510)3.71909273
21Mediastinal lymphadenopathy (HP:0100721)3.66928144
22Prolonged bleeding time (HP:0003010)3.66402890
23Vasculitis (HP:0002633)3.62603686
24Orchitis (HP:0100796)3.57138903
25Gastrointestinal stroma tumor (HP:0100723)3.31203479
26Meningitis (HP:0001287)3.26289622
27IgM deficiency (HP:0002850)3.26121668
28Vacuolated lymphocytes (HP:0001922)3.25330483
29Chest pain (HP:0100749)3.24957936
30Cellulitis (HP:0100658)3.23074877
31Chronic mucocutaneous candidiasis (HP:0002728)3.22003513
32Recurrent cutaneous fungal infections (HP:0011370)3.22003513
33Recurrent bronchitis (HP:0002837)3.19849277
34Abnormality of liposaccharide metabolism (HP:0010968)3.18936494
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.18936494
36Abnormality of glycolipid metabolism (HP:0010969)3.18936494
37Recurrent gram-negative bacterial infections (HP:0005420)3.09673173
38Panhypogammaglobulinemia (HP:0003139)3.09598686
39Leukocytosis (HP:0001974)3.03624620
40Inflammation of the large intestine (HP:0002037)2.97786090
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96248162
42Autoimmune thrombocytopenia (HP:0001973)2.91546249
43Eosinophilia (HP:0001880)2.90848985
44Hypochromic anemia (HP:0001931)2.89870221
45Epistaxis (HP:0000421)2.89292717
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.88654097
47Dysostosis multiplex (HP:0000943)2.88089396
48Autoimmune hemolytic anemia (HP:0001890)2.86033578
49Loss of speech (HP:0002371)2.85969990
50Gastrointestinal inflammation (HP:0004386)2.83123846
51Abnormality of T cells (HP:0002843)2.80792257
52Thyroiditis (HP:0100646)2.80699578
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76892473
54Gingival bleeding (HP:0000225)2.76160711
55Papilledema (HP:0001085)2.75645072
56Hepatosplenomegaly (HP:0001433)2.74364933
57Gingivitis (HP:0000230)2.73605954
58Colitis (HP:0002583)2.72747424
59Lymphopenia (HP:0001888)2.72706169
60Hypochromic microcytic anemia (HP:0004840)2.72025015
61Pustule (HP:0200039)2.69792160
62Pulmonary infiltrates (HP:0002113)2.67523761
63Abnormality of eosinophils (HP:0001879)2.67026019
64Arterial thrombosis (HP:0004420)2.66445962
65Agammaglobulinemia (HP:0004432)2.65133358
66Nasal polyposis (HP:0100582)2.61792645
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.61031271
68Abnormality of the fingertips (HP:0001211)2.58975245
69Pulmonary embolism (HP:0002204)2.57904060
70Severe combined immunodeficiency (HP:0004430)2.57288995
71Parakeratosis (HP:0001036)2.47753137
72Interstitial pulmonary disease (HP:0006530)2.46488200
73Slow saccadic eye movements (HP:0000514)2.43763366
74Thick nail (HP:0001805)2.42620479
75Verrucae (HP:0200043)2.42007966
76Papilloma (HP:0012740)2.42007966
77Recurrent pneumonia (HP:0006532)2.41148546
78Combined immunodeficiency (HP:0005387)2.40171803
79Emphysema (HP:0002097)2.38905906
80Small epiphyses (HP:0010585)2.38655559
81Increased IgM level (HP:0003496)2.38270903
82Anorexia (HP:0002039)2.37655056
83Episodic fever (HP:0001954)2.36557865
84Restrictive lung disease (HP:0002091)2.35705730
85IgA deficiency (HP:0002720)2.34345214
86IgG deficiency (HP:0004315)2.34285963
87Granulocytopenia (HP:0001913)2.33358074
88Disinhibition (HP:0000734)2.31376886
89Encephalitis (HP:0002383)2.30088065
90Keratoconjunctivitis sicca (HP:0001097)2.27357843
91B lymphocytopenia (HP:0010976)2.26324003
92Abnormality of B cell number (HP:0010975)2.26324003
93Sepsis (HP:0100806)2.25183248
94Osteomyelitis (HP:0002754)2.24829263
95Spontaneous hematomas (HP:0007420)2.23287507
96Hemoptysis (HP:0002105)2.17942516
97Microcytic anemia (HP:0001935)2.17443706
98Axonal loss (HP:0003447)2.15614549
99Hypergammaglobulinemia (HP:0010702)2.15595542
100Urticaria (HP:0001025)2.14252582
101Chronic diarrhea (HP:0002028)2.11141259
102Gangrene (HP:0100758)2.10201295
103Abnormality of the pleura (HP:0002103)2.09910080
104Abnormality of the nasal mucosa (HP:0000433)2.09906692
105Abnormal platelet volume (HP:0011876)2.09629484
106Petechiae (HP:0000967)2.09587560
107Hemiplegia (HP:0002301)2.08596455
108Recurrent lower respiratory tract infections (HP:0002783)2.06214180
109Keratoconjunctivitis (HP:0001096)2.05957733
110Abnormality of T cell physiology (HP:0011840)2.05575027
111Neurofibrillary tangles (HP:0002185)2.05569388
112Acute hepatic failure (HP:0006554)2.05557408
113Increased IgE level (HP:0003212)2.05044780
114Supranuclear gaze palsy (HP:0000605)2.04900513
115Basal ganglia calcification (HP:0002135)2.04799106
116Urinary glycosaminoglycan excretion (HP:0003541)2.04530513
117Mucopolysacchariduria (HP:0008155)2.04530513
118Viral hepatitis (HP:0006562)2.03348250
119Recurrent sinusitis (HP:0011108)2.03142760
120Degeneration of the lateral corticospinal tracts (HP:0002314)2.00498984
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00498984
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99890531
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99890531
124Abnormality of polysaccharide metabolism (HP:0011012)1.99890531
125Chronic sinusitis (HP:0011109)1.99278062
126Joint swelling (HP:0001386)1.97448668
127Purpura (HP:0000979)1.96568294
128Diplopia (HP:0000651)1.95963780
129Abnormality of binocular vision (HP:0011514)1.95963780
130Abnormality of the endocardium (HP:0004306)1.95796727
131Skin ulcer (HP:0200042)1.94637153
132Lymphoma (HP:0002665)1.92153116
133Vertigo (HP:0002321)1.91824921
134Stomach cancer (HP:0012126)1.84946067
135Glomerulopathy (HP:0100820)1.80839712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.86958160
2TXK3.73626123
3EPHB13.42946290
4IRAK42.89965994
5TBK12.62855877
6TYK22.58524448
7MAP3K142.45366817
8IKBKE2.41870409
9JAK32.28659393
10KIT2.21001399
11BLK2.11960453
12STK102.11639185
13ITK2.07812575
14FES2.07542002
15RIPK42.04809417
16CSK1.97861814
17IRAK31.95818561
18ZAP701.93103147
19CSF1R1.90366280
20IKBKB1.86669375
21CLK11.84441389
22JAK11.82365702
23STK391.77630901
24SYK1.71023046
25FGR1.64617178
26LCK1.64166420
27BTK1.59833440
28HCK1.57918115
29MST41.57565072
30MAP3K131.38592262
31TNIK1.36732880
32GRK61.32958287
33MAP3K111.24845430
34MARK31.22189955
35MAP3K31.22159919
36LYN1.22109159
37PRKCQ1.20656836
38SIK21.15006252
39MAP3K11.08175185
40PKN11.04394281
41TGFBR21.03060443
42MAPK121.00248096
43KSR20.99303721
44CAMKK10.98868659
45PRPF4B0.98761031
46TEC0.98550294
47SMG10.97745113
48YES10.96120193
49CDK120.92359088
50OXSR10.92142618
51PRKCH0.90501612
52JAK20.85284308
53PIK3CG0.84913171
54FGFR40.84354902
55CHUK0.82799115
56CAMKK20.82789558
57TYRO30.80309702
58ALK0.78309948
59ICK0.78259577
60IRAK10.76673536
61IRAK20.74500174
62MAP3K100.74107816
63SGK30.73423745
64MAP3K70.73149380
65CDK190.72509142
66PIM10.71920074
67SGK20.71553157
68FYN0.70622715
69FGFR30.69977610
70LRRK20.69945798
71TESK20.68266231
72NLK0.66035092
73TAOK20.64667415
74TAOK30.64354284
75STK110.63878984
76PDK10.60835014
77CAMK1G0.60718653
78SIK30.59285090
79PDGFRB0.58811815
80ERN10.57367948
81TNK20.56176099
82STK40.55971320
83BMPR20.54355356
84HIPK20.54130996
85PTK2B0.53605945
86DMPK0.52966512
87EEF2K0.52817538
88ABL10.52283397
89WNK10.51991645
90MATK0.51732547
91TRIB30.51641588
92EGFR0.50677213
93RET0.50013991
94PRKD20.49166897
95STK380.47048782
96BRD40.46999286
97MAP2K30.46873198
98DAPK20.45939758
99CDC42BPA0.44935046
100CSNK1A1L0.44836677
101SIK10.44539072
102SGK2230.44488511
103SGK4940.44488511
104PBK0.44360746
105PASK0.44360692
106RPS6KA40.43515200
107CAMK1D0.41742691
108ROCK20.40843077
109GRK70.40600629
110INSR0.40525498
111BMX0.40175497
112CDK40.39690968
113CAMK40.39118527
114PRKCD0.38506947
115MARK20.37546634
116MAP3K20.37500072
117PDPK10.37438546
118TRPM70.36985259
119MAPK110.36548790
120MAP3K50.36206390
121CSNK1G30.35890039
122MAPKAPK20.34952818
123GRK50.34833795
124UHMK10.33884858
125TAOK10.33572110
126MAPK70.33231650
127MELK0.30580090
128RAF10.30140275
129DYRK1B0.30027473
130PTK60.29909093
131EPHA30.27490117
132NME20.26340191
133GSK3A0.23402514
134RPS6KA50.23025140
135SRC0.21727191

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.01043199
2B cell receptor signaling pathway_Homo sapiens_hsa046622.63402669
3Leishmaniasis_Homo sapiens_hsa051402.63046091
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.44270051
5Osteoclast differentiation_Homo sapiens_hsa043802.40715099
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39234640
7T cell receptor signaling pathway_Homo sapiens_hsa046602.28761015
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.20211849
9Allograft rejection_Homo sapiens_hsa053302.19722496
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17296606
11Graft-versus-host disease_Homo sapiens_hsa053322.16465918
12Measles_Homo sapiens_hsa051622.03877162
13Asthma_Homo sapiens_hsa053101.96790016
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94850603
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.94297589
16Hematopoietic cell lineage_Homo sapiens_hsa046401.81475045
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80028076
18Antigen processing and presentation_Homo sapiens_hsa046121.77981303
19Malaria_Homo sapiens_hsa051441.73356589
20Lysosome_Homo sapiens_hsa041421.69941692
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66538189
22Tuberculosis_Homo sapiens_hsa051521.63484872
23Staphylococcus aureus infection_Homo sapiens_hsa051501.57768825
24Chemokine signaling pathway_Homo sapiens_hsa040621.57438555
25Rheumatoid arthritis_Homo sapiens_hsa053231.55898621
26Steroid biosynthesis_Homo sapiens_hsa001001.53225564
27Shigellosis_Homo sapiens_hsa051311.52178479
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50561043
29Pertussis_Homo sapiens_hsa051331.49403880
30Toxoplasmosis_Homo sapiens_hsa051451.45517880
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43974232
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43582646
33Autoimmune thyroid disease_Homo sapiens_hsa053201.40058705
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.39731397
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.36765444
36TNF signaling pathway_Homo sapiens_hsa046681.31749584
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26087827
38Apoptosis_Homo sapiens_hsa042101.25515973
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.24751795
40Salmonella infection_Homo sapiens_hsa051321.24694600
41Influenza A_Homo sapiens_hsa051641.23760823
42Other glycan degradation_Homo sapiens_hsa005111.22752784
43Legionellosis_Homo sapiens_hsa051341.16820660
44Herpes simplex infection_Homo sapiens_hsa051681.16291474
45Hepatitis B_Homo sapiens_hsa051611.10354499
46Acute myeloid leukemia_Homo sapiens_hsa052211.09171984
47Viral myocarditis_Homo sapiens_hsa054161.06327523
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05715166
49Pancreatic cancer_Homo sapiens_hsa052121.05557640
50Hepatitis C_Homo sapiens_hsa051601.04288654
51Phagosome_Homo sapiens_hsa041451.01984340
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00643895
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00243410
54Platelet activation_Homo sapiens_hsa046110.97044571
55Chronic myeloid leukemia_Homo sapiens_hsa052200.96495241
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.94307992
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94207072
58Type I diabetes mellitus_Homo sapiens_hsa049400.92459558
59African trypanosomiasis_Homo sapiens_hsa051430.91948620
60Renal cell carcinoma_Homo sapiens_hsa052110.91552477
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89300422
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87901033
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.87796261
64Long-term potentiation_Homo sapiens_hsa047200.87236865
65Endocytosis_Homo sapiens_hsa041440.84635259
66Endometrial cancer_Homo sapiens_hsa052130.80483543
67Epstein-Barr virus infection_Homo sapiens_hsa051690.79139339
68Regulation of autophagy_Homo sapiens_hsa041400.77755477
69VEGF signaling pathway_Homo sapiens_hsa043700.77492184
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74131110
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74026680
72Ether lipid metabolism_Homo sapiens_hsa005650.72227420
73GnRH signaling pathway_Homo sapiens_hsa049120.71131529
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.69160193
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67001693
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66293084
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66000266
78Sphingolipid metabolism_Homo sapiens_hsa006000.64733994
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62120754
80mTOR signaling pathway_Homo sapiens_hsa041500.60886744
81Colorectal cancer_Homo sapiens_hsa052100.56418557
82Prolactin signaling pathway_Homo sapiens_hsa049170.55801607
83Glioma_Homo sapiens_hsa052140.54203555
84HIF-1 signaling pathway_Homo sapiens_hsa040660.54100879
85Viral carcinogenesis_Homo sapiens_hsa052030.53805213
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52530899
87Non-small cell lung cancer_Homo sapiens_hsa052230.51728549
88MAPK signaling pathway_Homo sapiens_hsa040100.51473558
89Inositol phosphate metabolism_Homo sapiens_hsa005620.50782742
90Choline metabolism in cancer_Homo sapiens_hsa052310.50684364
91Type II diabetes mellitus_Homo sapiens_hsa049300.50037713
92Notch signaling pathway_Homo sapiens_hsa043300.49835420
93Insulin resistance_Homo sapiens_hsa049310.49228653
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48760547
95Collecting duct acid secretion_Homo sapiens_hsa049660.47992569
96Dorso-ventral axis formation_Homo sapiens_hsa043200.47309344
97HTLV-I infection_Homo sapiens_hsa051660.46889130
98Rap1 signaling pathway_Homo sapiens_hsa040150.46589273
99Cholinergic synapse_Homo sapiens_hsa047250.46584205
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46349695
101Estrogen signaling pathway_Homo sapiens_hsa049150.45436060
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44299134
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44213999
104Amoebiasis_Homo sapiens_hsa051460.42037228
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.41670861
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40570136
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39488077
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.39252110
109Oxytocin signaling pathway_Homo sapiens_hsa049210.37902104
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35878278
111MicroRNAs in cancer_Homo sapiens_hsa052060.35396868
112Prostate cancer_Homo sapiens_hsa052150.34951183
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31605358
114Small cell lung cancer_Homo sapiens_hsa052220.29518601
115Ras signaling pathway_Homo sapiens_hsa040140.29371790
116FoxO signaling pathway_Homo sapiens_hsa040680.28889067
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28774832
118ErbB signaling pathway_Homo sapiens_hsa040120.28653269

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