SEMA4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1convergent extension (GO:0060026)3.75568765
2neuron projection extension involved in neuron projection guidance (GO:1902284)3.73342665
3axon extension involved in axon guidance (GO:0048846)3.73342665
4* semaphorin-plexin signaling pathway (GO:0071526)3.69715772
5polarized epithelial cell differentiation (GO:0030859)3.58544245
6hemidesmosome assembly (GO:0031581)3.56626018
7cell-cell junction maintenance (GO:0045217)3.53309518
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48097381
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41647767
10basement membrane organization (GO:0071711)3.34566491
11vagina development (GO:0060068)3.26990085
12hippo signaling (GO:0035329)3.26490566
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.25743866
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.23846373
15ear development (GO:0043583)3.21924596
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.21376313
17* cell migration in hindbrain (GO:0021535)3.21289253
18negative regulation of catenin import into nucleus (GO:0035414)3.20193455
19protein heterotrimerization (GO:0070208)3.14627337
20plasma membrane repair (GO:0001778)3.11636806
21vascular endothelial growth factor signaling pathway (GO:0038084)3.03844443
22female genitalia development (GO:0030540)3.01228279
23establishment or maintenance of monopolar cell polarity (GO:0061339)2.99233774
24establishment of monopolar cell polarity (GO:0061162)2.99233774
25regulation of posttranscriptional gene silencing (GO:0060147)2.95236774
26regulation of gene silencing by miRNA (GO:0060964)2.95236774
27regulation of gene silencing by RNA (GO:0060966)2.95236774
28retina vasculature morphogenesis in camera-type eye (GO:0061299)2.94889041
29cell adhesion mediated by integrin (GO:0033627)2.94010426
30cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.93789474
31regulation of p38MAPK cascade (GO:1900744)2.93035180
32neural tube development (GO:0021915)2.89962489
33positive regulation of synapse maturation (GO:0090129)2.89805148
34cell-substrate junction assembly (GO:0007044)2.89617237
35body morphogenesis (GO:0010171)2.87104863
36post-embryonic morphogenesis (GO:0009886)2.83960631
37notochord development (GO:0030903)2.83470413
38intracellular estrogen receptor signaling pathway (GO:0030520)2.80122507
39branching involved in salivary gland morphogenesis (GO:0060445)2.79996669
40adherens junction assembly (GO:0034333)2.79993602
41endothelial cell morphogenesis (GO:0001886)2.79642192
42gastrulation with mouth forming second (GO:0001702)2.79625630
43lung epithelium development (GO:0060428)2.79016684
44ganglion development (GO:0061548)2.78952420
45coronary vasculature morphogenesis (GO:0060977)2.76743060
46endodermal cell differentiation (GO:0035987)2.75502276
47cell migration involved in sprouting angiogenesis (GO:0002042)2.74588984
48paraxial mesoderm development (GO:0048339)2.72800884
49cytoplasmic mRNA processing body assembly (GO:0033962)2.71406478
50insulin-like growth factor receptor signaling pathway (GO:0048009)2.71302289
51epithelial cell-cell adhesion (GO:0090136)2.70993956
52layer formation in cerebral cortex (GO:0021819)2.70625611
53regulation of cardioblast proliferation (GO:0003264)2.67170488
54regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67170488
55adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67164599
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66419507
57regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.66153354
58bone trabecula formation (GO:0060346)2.65491880
59growth hormone receptor signaling pathway (GO:0060396)2.64347536
60cardiac right ventricle morphogenesis (GO:0003215)2.63962944
61renal system development (GO:0072001)2.63439126
62embryonic retina morphogenesis in camera-type eye (GO:0060059)2.62092332
63negative regulation of fatty acid transport (GO:2000192)2.60815478
64establishment of nucleus localization (GO:0040023)2.60360131
65negative regulation of axon extension involved in axon guidance (GO:0048843)2.60242505
66regulation of axon extension involved in axon guidance (GO:0048841)2.59736172
67protein-DNA complex disassembly (GO:0032986)2.59368248
68nucleosome disassembly (GO:0006337)2.59368248
69lymph vessel development (GO:0001945)2.59032973
70collecting duct development (GO:0072044)2.58518897
71regulation of synapse maturation (GO:0090128)2.58330450
72peptidyl-arginine omega-N-methylation (GO:0035247)2.58119826
73establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58023851
74establishment or maintenance of bipolar cell polarity (GO:0061245)2.58023851
75protein localization to endosome (GO:0036010)2.57779288
76embryonic foregut morphogenesis (GO:0048617)2.57023183
77embryonic camera-type eye morphogenesis (GO:0048596)2.55266301
78mannose metabolic process (GO:0006013)2.53686202
79negative regulation of cell fate commitment (GO:0010454)2.52024963
80outer ear morphogenesis (GO:0042473)2.50973557
81peptidyl-tyrosine autophosphorylation (GO:0038083)2.50719373
82positive regulation of glycogen biosynthetic process (GO:0045725)2.50510597
83aorta morphogenesis (GO:0035909)2.49972059
84stress fiber assembly (GO:0043149)2.49234891
85positive regulation of p38MAPK cascade (GO:1900745)2.47926208
86collagen fibril organization (GO:0030199)2.47275100
87non-canonical Wnt signaling pathway (GO:0035567)2.47143698
88mitochondrion transport along microtubule (GO:0047497)2.47018439
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47018439
90atrioventricular valve morphogenesis (GO:0003181)2.46915776
91regulation of catenin import into nucleus (GO:0035412)2.46879433
92blood vessel endothelial cell migration (GO:0043534)2.46680794
93adherens junction organization (GO:0034332)2.46567261
94neuronal ion channel clustering (GO:0045161)2.46454602
95glial cell proliferation (GO:0014009)2.44592899
96dorsal/ventral axis specification (GO:0009950)2.44532272
97mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44488250
98dopamine receptor signaling pathway (GO:0007212)2.44453634
99regulation of glycogen (starch) synthase activity (GO:2000465)2.44327943
100establishment of mitochondrion localization (GO:0051654)2.43860306
101neuron remodeling (GO:0016322)2.43852653
102neuron recognition (GO:0008038)2.43668866
103histone arginine methylation (GO:0034969)2.43362274
104cerebellar granule cell differentiation (GO:0021707)2.42959625
105renal filtration (GO:0097205)2.42711142
106regulation of fatty acid beta-oxidation (GO:0031998)2.42484829
107heart morphogenesis (GO:0003007)2.42384461
108proximal/distal pattern formation (GO:0009954)2.41114629
109regulation of histone H3-K27 methylation (GO:0061085)2.40899516
110endothelial cell chemotaxis (GO:0035767)2.40347204
111epithelial cell fate commitment (GO:0072148)2.40226137
112lung-associated mesenchyme development (GO:0060484)2.39032508
113regulation of establishment of planar polarity (GO:0090175)2.38737309
114substrate adhesion-dependent cell spreading (GO:0034446)2.38664055
115negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.38578115
116proline biosynthetic process (GO:0006561)2.38234132
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37870696
118positive regulation of protein kinase C signaling (GO:0090037)2.37725015
119embryonic eye morphogenesis (GO:0048048)2.37480908
120regulation of heart morphogenesis (GO:2000826)2.37160145
121apoptotic process involved in morphogenesis (GO:0060561)2.36931724
122regulation of hippo signaling (GO:0035330)2.35314009
123establishment of epithelial cell polarity (GO:0090162)2.35020190
124axonal fasciculation (GO:0007413)2.34847600
125morphogenesis of an epithelial sheet (GO:0002011)2.34371934
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33697366
127artery morphogenesis (GO:0048844)2.33534141
128regulation of cell fate specification (GO:0042659)2.33378740
129regulation of NFAT protein import into nucleus (GO:0051532)2.33364372
130collagen metabolic process (GO:0032963)2.33239240
131regulation of transforming growth factor beta2 production (GO:0032909)2.33154605
132peripheral nervous system axon ensheathment (GO:0032292)2.33095821
133myelination in peripheral nervous system (GO:0022011)2.33095821
134positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32965885
135eye morphogenesis (GO:0048592)2.32641878
136negative regulation of chondrocyte differentiation (GO:0032331)2.32037518
137camera-type eye morphogenesis (GO:0048593)2.31896967
138cell junction maintenance (GO:0034331)2.31302077
139apoptotic cell clearance (GO:0043277)2.31276140
140morphogenesis of an endothelium (GO:0003159)2.30731481
141endothelial tube morphogenesis (GO:0061154)2.30731481
142Notch signaling involved in heart development (GO:0061314)2.30536920
143establishment of apical/basal cell polarity (GO:0035089)2.30298203
144negative regulation of cell size (GO:0045792)2.29440406
145cardiac muscle cell proliferation (GO:0060038)2.29404070
146regulation of axon guidance (GO:1902667)2.29245602
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29099319
148focal adhesion assembly (GO:0048041)2.28621218
149cell-substrate adherens junction assembly (GO:0007045)2.28621218
150endocardial cushion development (GO:0003197)2.28461698
151synaptic vesicle docking involved in exocytosis (GO:0016081)2.28363633
152cardiac myofibril assembly (GO:0055003)2.27755520
153extracellular matrix disassembly (GO:0022617)2.27487803
154negative regulation of cell fate specification (GO:0009996)2.27291406
155germ cell migration (GO:0008354)2.26875932
156fibroblast migration (GO:0010761)2.26867560
157proline metabolic process (GO:0006560)2.26423651
158cellular response to growth hormone stimulus (GO:0071378)2.26419265
159negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.26173005
160establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25971886
161regulation of glucose import in response to insulin stimulus (GO:2001273)2.25705110
162cell migration involved in heart development (GO:0060973)2.24810376
163striated muscle atrophy (GO:0014891)2.23013645
164apical protein localization (GO:0045176)2.21372453
165neuromuscular process controlling balance (GO:0050885)2.21203747
166positive regulation of fatty acid beta-oxidation (GO:0032000)2.20069741
167vocalization behavior (GO:0071625)2.19974899
168peptidyl-arginine methylation (GO:0018216)2.19375713
169peptidyl-arginine N-methylation (GO:0035246)2.19375713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.53228213
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28829538
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.77063412
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.65964239
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61735530
6CLOCK_20551151_ChIP-Seq_293T_Human2.48978521
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.39410576
8* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36189242
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35620171
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27138599
11KDM2B_26808549_Chip-Seq_K562_Human2.12237517
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08726828
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05919831
14KDM2B_26808549_Chip-Seq_DND41_Human2.04185227
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.02039529
16* ELK3_25401928_ChIP-Seq_HUVEC_Human1.99701777
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99152320
18* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.95958275
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83221813
20ZNF263_19887448_ChIP-Seq_K562_Human1.76739717
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76505999
22CTCF_27219007_Chip-Seq_Bcells_Human1.75971711
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75880663
24P68_20966046_ChIP-Seq_HELA_Human1.74622377
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74429071
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74429071
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.74012659
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70453790
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70101782
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68866653
31SMC4_20622854_ChIP-Seq_HELA_Human1.67382307
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66842864
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66327714
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66141172
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65447177
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64991234
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62843734
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62215912
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62207897
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61553130
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60409940
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.60144667
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.59927051
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58595771
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57989030
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57352207
47* LXR_22292898_ChIP-Seq_THP-1_Human1.56448923
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53813109
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.47039060
50DROSHA_22980978_ChIP-Seq_HELA_Human1.46642298
51RACK7_27058665_Chip-Seq_MCF-7_Human1.46114116
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.44499993
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.44425962
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.43616886
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43478823
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42888503
57* RNF2_27304074_Chip-Seq_ESCs_Mouse1.42736631
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.42695215
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.41681247
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40762213
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40585012
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38805117
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38703218
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.37475964
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.37450436
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.37400293
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36074171
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35672346
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33796957
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33734377
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32702473
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32702473
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32702473
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32106506
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.31760254
76EZH2_22144423_ChIP-Seq_EOC_Human1.31560739
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.31279966
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30243010
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29597015
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29484764
81* TBX20_22328084_ChIP-Seq_HEART_Mouse1.29227513
82* TBX20_22080862_ChIP-Seq_HEART_Mouse1.29227513
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28701711
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26904484
85* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26281614
86* EZH2_27294783_Chip-Seq_ESCs_Mouse1.25620207
87MYC_22102868_ChIP-Seq_BL_Human1.25568071
88* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24752103
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24445915
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22256187
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21633171
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.19549907
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19384268
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.19348769
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19230279
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19091005
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18997559
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.18254963
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17811378
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16880640
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16873806
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.16839355
103* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16090146
104TP53_22127205_ChIP-Seq_IMR90_Human1.14392036
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14327494
106CREB1_26743006_Chip-Seq_LNCaP_Human1.13550126
107* TET1_21490601_ChIP-Seq_MESCs_Mouse1.12918321
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11469953
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11210548
110TP53_23651856_ChIP-Seq_MEFs_Mouse1.11169767
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11100339
112JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11065627
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10646454
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09138030
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08974975
116* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08948505
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08169745
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07969131
119* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07617964
120OCT4_19829295_ChIP-Seq_ESCs_Human1.05348413
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05217235
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.03825282
123AHR_22903824_ChIP-Seq_MCF-7_Human1.03554458
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02654967
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02450418
126* TP63_22573176_ChIP-Seq_HFKS_Human1.02068499
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01487043
128REST_21632747_ChIP-Seq_MESCs_Mouse1.01444414
129BRD4_25478319_ChIP-Seq_HGPS_Human1.01076978
130CJUN_26792858_Chip-Seq_BT549_Human1.01008009
131* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00735205
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00582232
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00319998
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98679760
135KLF5_25053715_ChIP-Seq_YYC3_Human0.98661481
136ATF3_27146783_Chip-Seq_COLON_Human0.98387477
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.97351874
138* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96153945
139VDR_21846776_ChIP-Seq_THP-1_Human0.95472317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.07832514
2MP0003705_abnormal_hypodermis_morpholog4.03608928
3MP0008438_abnormal_cutaneous_collagen3.47605384
4MP0005623_abnormal_meninges_morphology3.11693737
5MP0003878_abnormal_ear_physiology2.82074607
6MP0005377_hearing/vestibular/ear_phenot2.82074607
7MP0000566_synostosis2.78796666
8MP0010368_abnormal_lymphatic_system2.55033701
9MP0004859_abnormal_synaptic_plasticity2.34527757
10MP0000733_abnormal_muscle_development2.28663823
11MP0005275_abnormal_skin_tensile2.25645234
12MP0005423_abnormal_somatic_nervous2.22869814
13MP0000537_abnormal_urethra_morphology2.21199634
14MP0010030_abnormal_orbit_morphology2.20565747
15MP0003566_abnormal_cell_adhesion2.13277180
16MP0005076_abnormal_cell_differentiation2.07602797
17MP0004858_abnormal_nervous_system2.01334879
18MP0001849_ear_inflammation1.91408012
19MP0003385_abnormal_body_wall1.87004081
20MP0000534_abnormal_ureter_morphology1.85812297
21MP0002254_reproductive_system_inflammat1.84808459
22MP0004264_abnormal_extraembryonic_tissu1.77982974
23MP0009278_abnormal_bone_marrow1.77964405
24MP0009053_abnormal_anal_canal1.77460501
25MP0004084_abnormal_cardiac_muscle1.77413775
26MP0006054_spinal_hemorrhage1.77095145
27MP0000751_myopathy1.76822764
28MP0003279_aneurysm1.74237334
29MP0005503_abnormal_tendon_morphology1.73397198
30MP0004133_heterotaxia1.73236172
31MP0004782_abnormal_surfactant_physiolog1.71840471
32MP0005409_darkened_coat_color1.70985899
33MP0002653_abnormal_ependyma_morphology1.68703654
34MP0003942_abnormal_urinary_system1.68414262
35MP0003787_abnormal_imprinting1.66906184
36MP0009672_abnormal_birth_weight1.62927204
37MP0003890_abnormal_embryonic-extraembry1.61294631
38MP0000462_abnormal_digestive_system1.56165725
39MP0003122_maternal_imprinting1.54126693
40MP0001879_abnormal_lymphatic_vessel1.53976733
41MP0004381_abnormal_hair_follicle1.53972013
42MP0003136_yellow_coat_color1.53577887
43MP0000767_abnormal_smooth_muscle1.53167027
44MP0003329_amyloid_beta_deposits1.51843793
45MP0001958_emphysema1.50080793
46MP0005257_abnormal_intraocular_pressure1.49469735
47MP0010234_abnormal_vibrissa_follicle1.49233275
48MP0003115_abnormal_respiratory_system1.47594098
49MP0002184_abnormal_innervation1.47582159
50MP0003091_abnormal_cell_migration1.45738676
51MP0000516_abnormal_urinary_system1.44604729
52MP0005367_renal/urinary_system_phenotyp1.44604729
53MP0010352_gastrointestinal_tract_polyps1.39464690
54MP0002896_abnormal_bone_mineralization1.36669413
55MP0003303_peritoneal_inflammation1.35133375
56MP0003300_gastrointestinal_ulcer1.34863309
57MP0003861_abnormal_nervous_system1.34010871
58MP0001502_abnormal_circadian_rhythm1.32744364
59MP0002234_abnormal_pharynx_morphology1.32360978
60MP0004270_analgesia1.30268854
61MP0002925_abnormal_cardiovascular_devel1.29393106
62MP0005508_abnormal_skeleton_morphology1.29373304
63MP0005171_absent_coat_pigmentation1.28057869
64MP0002932_abnormal_joint_morphology1.26701334
65MP0003635_abnormal_synaptic_transmissio1.25878954
66MP0000579_abnormal_nail_morphology1.24817731
67MP0000428_abnormal_craniofacial_morphol1.24284723
68MP0005248_abnormal_Harderian_gland1.23867109
69MP0003283_abnormal_digestive_organ1.23127831
70MP0003567_abnormal_fetal_cardiomyocyte1.23040353
71MP0004885_abnormal_endolymph1.22771155
72MP0002098_abnormal_vibrissa_morphology1.22210401
73MP0003935_abnormal_craniofacial_develop1.21599687
74MP0009384_cardiac_valve_regurgitation1.21201676
75MP0000750_abnormal_muscle_regeneration1.19904637
76MP0000955_abnormal_spinal_cord1.19396729
77MP0002063_abnormal_learning/memory/cond1.19274564
78MP0001348_abnormal_lacrimal_gland1.18605650
79MP0004510_myositis1.18074292
80MP0001915_intracranial_hemorrhage1.15840490
81MP0005187_abnormal_penis_morphology1.15489596
82MP0003045_fibrosis1.12602400
83MP0009780_abnormal_chondrocyte_physiolo1.11950919
84MP0010678_abnormal_skin_adnexa1.11491242
85MP0005023_abnormal_wound_healing1.11465228
86MP0008961_abnormal_basal_metabolism1.11089470
87MP0003938_abnormal_ear_development1.10164657
88MP0010630_abnormal_cardiac_muscle1.08184646
89MP0000003_abnormal_adipose_tissue1.07521284
90MP0001299_abnormal_eye_distance/1.07158014
91MP0003119_abnormal_digestive_system1.06899204
92MP0005167_abnormal_blood-brain_barrier1.06605059
93MP0002697_abnormal_eye_size1.04914672
94MP0001346_abnormal_lacrimal_gland1.04652900
95MP0006292_abnormal_olfactory_placode1.04532706
96MP0002152_abnormal_brain_morphology1.04412251
97MP0000049_abnormal_middle_ear1.04192454
98MP0004087_abnormal_muscle_fiber1.03745494
99MP0002282_abnormal_trachea_morphology1.03422448
100MP0009250_abnormal_appendicular_skeleto1.03417606
101MP0000383_abnormal_hair_follicle1.02675407
102MP0002108_abnormal_muscle_morphology1.02396745
103MP0001614_abnormal_blood_vessel1.01889281
104MP0006138_congestive_heart_failure1.01188680
105MP0003755_abnormal_palate_morphology1.00963797
106MP0004197_abnormal_fetal_growth/weight/1.00935802
107MP0002116_abnormal_craniofacial_bone1.00006931
108MP0000778_abnormal_nervous_system0.96417212
109MP0003453_abnormal_keratinocyte_physiol0.96056237
110MP0002060_abnormal_skin_morphology0.94633698
111MP0009703_decreased_birth_body0.94571612
112MP0004185_abnormal_adipocyte_glucose0.94139923
113MP0003634_abnormal_glial_cell0.94012832
114MP0003123_paternal_imprinting0.93180384
115MP0005083_abnormal_biliary_tract0.92781981
116MP0001293_anophthalmia0.92300124
117MP0003880_abnormal_central_pattern0.92107387
118MP0003879_abnormal_hair_cell0.91572144
119MP0002572_abnormal_emotion/affect_behav0.91519566
120MP0002128_abnormal_blood_circulation0.90770971
121MP0003937_abnormal_limbs/digits/tail_de0.89842936
122MP0002882_abnormal_neuron_morphology0.89394285
123MP0001968_abnormal_touch/_nociception0.86897104
124MP0002085_abnormal_embryonic_tissue0.85693250
125MP0000026_abnormal_inner_ear0.84427446
126MP0002092_abnormal_eye_morphology0.84336099
127MP0000569_abnormal_digit_pigmentation0.84249956
128MP0002249_abnormal_larynx_morphology0.83414122
129MP0002751_abnormal_autonomic_nervous0.83066879
130MP0002734_abnormal_mechanical_nocicepti0.82786195
131MP0002557_abnormal_social/conspecific_i0.82005614
132MP0005197_abnormal_uvea_morphology0.81860245
133MP0000266_abnormal_heart_morphology0.81545157
134MP0005375_adipose_tissue_phenotype0.81247240
135MP0000432_abnormal_head_morphology0.81193729
136MP0003828_pulmonary_edema0.80995355
137MP0000377_abnormal_hair_follicle0.80876583
138MP0000678_abnormal_parathyroid_gland0.80793634
139MP0003948_abnormal_gas_homeostasis0.80320218
140MP0002081_perinatal_lethality0.79858368
141MP0004130_abnormal_muscle_cell0.79779281
142MP0002111_abnormal_tail_morphology0.79478854
143MP0002084_abnormal_developmental_patter0.79211379
144MP0002822_catalepsy0.78800267
145MP0002796_impaired_skin_barrier0.78641389
146MP0002089_abnormal_postnatal_growth/wei0.78043823
147MP0004145_abnormal_muscle_electrophysio0.77917031
148MP0002233_abnormal_nose_morphology0.77632743
149MP0002106_abnormal_muscle_physiology0.77329476
150MP0002064_seizures0.77049006
151MP0004233_abnormal_muscle_weight0.76316818
152MP0000163_abnormal_cartilage_morphology0.75965610
153MP0002938_white_spotting0.74745250
154MP0003941_abnormal_skin_development0.74731749
155MP0002752_abnormal_somatic_nervous0.71529200

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.24554924
2Cerebral aneurysm (HP:0004944)4.21999840
3Protrusio acetabuli (HP:0003179)3.77894526
4Hyperacusis (HP:0010780)3.75158139
5Premature rupture of membranes (HP:0001788)3.40204645
6Bladder diverticulum (HP:0000015)3.37623825
7Broad metatarsal (HP:0001783)3.31087512
8Renal duplication (HP:0000075)3.17092623
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16612997
10Short 4th metacarpal (HP:0010044)3.16612997
11Atrophic scars (HP:0001075)3.10558601
12J-shaped sella turcica (HP:0002680)3.03841105
13Ankle contracture (HP:0006466)3.02066469
14Renovascular hypertension (HP:0100817)2.98045912
15Elfin facies (HP:0004428)2.95298770
16Overriding aorta (HP:0002623)2.82151596
17Obstructive sleep apnea (HP:0002870)2.79878939
18Aortic dissection (HP:0002647)2.70596405
19Abnormality of the 4th metacarpal (HP:0010012)2.70518057
20Abnormality of the aortic arch (HP:0012303)2.67586413
21Flat cornea (HP:0007720)2.62049007
22Mitral valve prolapse (HP:0001634)2.57170696
23Bowel diverticulosis (HP:0005222)2.54206337
24Increased connective tissue (HP:0009025)2.54106213
25Lymphangioma (HP:0100764)2.49506841
26Scapular winging (HP:0003691)2.47942858
27Insomnia (HP:0100785)2.45339687
28Aortic aneurysm (HP:0004942)2.44253653
29Wrist flexion contracture (HP:0001239)2.37034775
30Long palpebral fissure (HP:0000637)2.36483647
31Deviation of the hallux (HP:0010051)2.34923932
32Thin ribs (HP:0000883)2.33927907
33Right ventricular cardiomyopathy (HP:0011663)2.33091425
34Type 1 muscle fiber predominance (HP:0003803)2.32590511
35Fragile skin (HP:0001030)2.32073606
36Aneurysm (HP:0002617)2.31123825
37Hallux valgus (HP:0001822)2.28056105
38Dilatation of the ascending aorta (HP:0005111)2.24486197
39Milia (HP:0001056)2.22781259
40Morphological abnormality of the inner ear (HP:0011390)2.20403982
41Reticulocytosis (HP:0001923)2.20018041
42Asymmetry of the thorax (HP:0001555)2.18591522
43Metaphyseal cupping (HP:0003021)2.18208426
44Difficulty running (HP:0009046)2.16605824
45Choanal stenosis (HP:0000452)2.15564601
46Buphthalmos (HP:0000557)2.15127663
47Megalocornea (HP:0000485)2.15110649
48Severe Myopia (HP:0011003)2.14817161
49Premature skin wrinkling (HP:0100678)2.14376911
50Striae distensae (HP:0001065)2.12398697
51Spinal rigidity (HP:0003306)2.12119443
52Aplasia involving bones of the extremities (HP:0009825)2.10993923
53Aplasia involving bones of the upper limbs (HP:0009823)2.10993923
54Aplasia of the phalanges of the hand (HP:0009802)2.10993923
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09786086
56Morphological abnormality of the middle ear (HP:0008609)2.08953559
57Arnold-Chiari malformation (HP:0002308)2.08510866
58Disproportionate tall stature (HP:0001519)2.07627743
59Arterial tortuosity (HP:0005116)2.06575243
60Abnormality of cochlea (HP:0000375)2.04943412
61Increased density of long bones (HP:0006392)2.04942409
62Increased variability in muscle fiber diameter (HP:0003557)2.03970939
63Rib fusion (HP:0000902)2.03365009
64Abnormality of the fingertips (HP:0001211)2.01479443
65Myelomeningocele (HP:0002475)2.00597292
66Dysmetric saccades (HP:0000641)2.00528517
67Pointed chin (HP:0000307)2.00322209
68High anterior hairline (HP:0009890)2.00148931
69Vitreoretinal degeneration (HP:0000655)1.99820846
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99457712
71Overgrowth (HP:0001548)1.99080387
72Termporal pattern (HP:0011008)1.98377399
73Insidious onset (HP:0003587)1.98377399
74Bilateral microphthalmos (HP:0007633)1.96714431
75Ulnar bowing (HP:0003031)1.96265314
76Spina bifida occulta (HP:0003298)1.95539786
77Truncus arteriosus (HP:0001660)1.95077309
78Bronchomalacia (HP:0002780)1.94832917
79Neonatal hypoglycemia (HP:0001998)1.94734088
80Enlarged penis (HP:0000040)1.94031453
81Vascular tortuosity (HP:0004948)1.93687188
82Precocious puberty (HP:0000826)1.93365355
83Persistence of primary teeth (HP:0006335)1.93318096
84Shawl scrotum (HP:0000049)1.92256558
85Camptodactyly of toe (HP:0001836)1.89177723
86Hyperthyroidism (HP:0000836)1.84956932
87Blue sclerae (HP:0000592)1.84359817
88Subacute progressive viral hepatitis (HP:0006572)1.84339914
89Broad ribs (HP:0000885)1.84076942
90Chin dimple (HP:0010751)1.84055769
91Broad palm (HP:0001169)1.83507954
92Hepatoblastoma (HP:0002884)1.83204083
93Hematochezia (HP:0002573)1.82716380
94Bicornuate uterus (HP:0000813)1.82141492
95Peritonitis (HP:0002586)1.82047874
96Concave nail (HP:0001598)1.81794318
97Epileptic encephalopathy (HP:0200134)1.81667054
98Biconcave vertebral bodies (HP:0004586)1.80746867
99Hyporeflexia of lower limbs (HP:0002600)1.80735710
100Difficulty climbing stairs (HP:0003551)1.80382299
101Soft skin (HP:0000977)1.80282616
102Thin bony cortex (HP:0002753)1.80046611
103Muscle fiber splitting (HP:0003555)1.79911208
104Skull defect (HP:0001362)1.79822537
105Mildly elevated creatine phosphokinase (HP:0008180)1.79461256
106Tracheal stenosis (HP:0002777)1.78811676
107Bowel incontinence (HP:0002607)1.78776461
108Abnormality of skeletal muscle fiber size (HP:0012084)1.77645355
109Germ cell neoplasia (HP:0100728)1.77620563
110Patellar dislocation (HP:0002999)1.76441958
111Cutaneous syndactyly (HP:0012725)1.76288684
112Patellar aplasia (HP:0006443)1.75072796
113Genu recurvatum (HP:0002816)1.74879983
114Rectal prolapse (HP:0002035)1.74617591
115Stridor (HP:0010307)1.74342548
116Abnormality of the diencephalon (HP:0010662)1.73718570
117Broad distal phalanx of finger (HP:0009836)1.72200391
118Esophageal varix (HP:0002040)1.70461278
119Coronal craniosynostosis (HP:0004440)1.69092118
120Radial bowing (HP:0002986)1.68908730
121Cutaneous finger syndactyly (HP:0010554)1.68879386
122Heterotopia (HP:0002282)1.68648325
123Turricephaly (HP:0000262)1.68137701
124Joint laxity (HP:0001388)1.67508273
125Genetic anticipation (HP:0003743)1.66487906
126Hypercalciuria (HP:0002150)1.65391837
127Macroorchidism (HP:0000053)1.64743770
128Ulnar claw (HP:0001178)1.64254399
129Absent epiphyses (HP:0010577)1.63970085
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63970085
131Broad thumb (HP:0011304)1.63440933
132Abnormality of the peritoneum (HP:0002585)1.62822042
133Abnormality of the lacrimal duct (HP:0011481)1.62819672
134Abnormality of reticulocytes (HP:0004312)1.62723678
135Follicular hyperkeratosis (HP:0007502)1.62667583
136Hyperextensible skin (HP:0000974)1.62611600
137Hypoplastic ischia (HP:0003175)1.62579190
138Partial duplication of thumb phalanx (HP:0009944)1.62105058
139Increased nuchal translucency (HP:0010880)1.61890918
140Neoplasm of the heart (HP:0100544)1.61804061
141Broad face (HP:0000283)1.61613050
142Upper limb amyotrophy (HP:0009129)1.61578231
143Distal upper limb amyotrophy (HP:0007149)1.61578231
144Myokymia (HP:0002411)1.61257165
145Anterior segment dysgenesis (HP:0007700)1.60663067
146Pseudobulbar signs (HP:0002200)1.59987460
147Aplasia/Hypoplasia of the patella (HP:0006498)1.59703411
148Wormian bones (HP:0002645)1.59597863
149Bowing of the arm (HP:0006488)1.59461998
150Bowed forearm bones (HP:0003956)1.59461998
151Broad phalanges of the hand (HP:0009768)1.59446255
152Deformed sella turcica (HP:0002681)1.59219512
153Hypopigmentation of the fundus (HP:0007894)1.59216434
154Venous abnormality (HP:0002624)1.59036179
155Broad forehead (HP:0000337)1.59030024
156Birth length less than 3rd percentile (HP:0003561)1.58305819
157Hypoplasia of the iris (HP:0007676)1.58065962
158Long toe (HP:0010511)1.57753840
159Joint contractures involving the joints of the feet (HP:0100492)1.57345492
160Flexion contracture of toe (HP:0005830)1.57345492
161Hypercortisolism (HP:0001578)1.57024115
162Annular pancreas (HP:0001734)1.54829208
163Cervical subluxation (HP:0003308)1.54216047
164Trigonocephaly (HP:0000243)1.53780165
165Partial agenesis of the corpus callosum (HP:0001338)1.53096146
166Wide anterior fontanel (HP:0000260)1.52876404
167Midline defect of the nose (HP:0004122)1.52250667
168Elbow flexion contracture (HP:0002987)1.51143046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.16751608
2PKN23.32565438
3SMG13.09184994
4RIPK13.07354089
5EPHB22.77041492
6TTN2.58642814
7MAP3K102.50741663
8PDGFRA2.49974177
9PTK62.42121792
10DDR22.32270729
11EPHB12.31017553
12LATS12.29175883
13TIE12.24049831
14EEF2K2.24045676
15PIK3CA2.23742569
16ICK2.11732421
17TGFBR22.00348083
18LATS21.97645189
19EPHA31.97448306
20SIK11.86734453
21PAK41.73601636
22ERN11.72856482
23PTK21.67434386
24DMPK1.60390128
25NTRK21.54029432
26MAPKAPK31.49678829
27TYRO31.47456459
28CAMK1G1.43915687
29SIK21.36120306
30RET1.33374509
31KDR1.32546628
32CAMK1D1.32412799
33FER1.32251950
34PAK21.32185237
35CDK121.31290108
36NME11.29742895
37TLK11.27801587
38BMX1.26708851
39WNK41.26530023
40FGFR41.20867294
41PDGFRB1.19140771
42ERBB21.18151576
43MTOR1.17325962
44MAPK151.15524145
45NTRK31.12362258
46TGFBR11.09003808
47PRKD31.07359641
48ALK1.04392408
49FGFR21.04134099
50SCYL21.02599658
51EPHA20.97701680
52FGFR10.97301756
53EPHA40.93858268
54MARK10.93607553
55MUSK0.90458069
56RPS6KA60.88817020
57PAK60.88164534
58LRRK20.87689598
59NEK60.85018736
60ILK0.84771085
61PTK2B0.83534207
62MET0.83208884
63CDK60.80893010
64RPS6KA20.76704150
65KSR10.75538171
66RPS6KB20.75042830
67PRKD10.72121656
68MARK20.72040130
69CAMKK10.71469535
70ERBB30.71446020
71KSR20.70803051
72FGFR30.70766587
73TSSK60.67973121
74PRKD20.67968661
75ROCK10.66671704
76MAP3K60.65505989
77MAP3K90.65166148
78MAPK120.65144729
79PAK30.64796129
80STK30.63253397
81HIPK20.62317798
82CDC42BPA0.62298674
83GSK3A0.61799375
84MAP3K20.61410120
85LIMK10.60570610
86PDPK10.60112844
87DYRK1B0.58304041
88LMTK20.57185868
89MAP3K70.53478746
90MAP2K20.53192883
91PRKCZ0.52989522
92ROCK20.51855319
93PRKAA10.51843798
94SGK4940.51385825
95SGK2230.51385825
96MAPK80.50928273
97CAMK2B0.50037243
98SRC0.49949530
99MAPKAPK50.48722441
100RPS6KB10.48307989
101NTRK10.47887462
102CAMK40.47069314
103PRPF4B0.46375544
104PRKCH0.45195964
105PHKG10.44657920
106PHKG20.44657920
107DAPK20.43390793
108BRD40.42877737
109RPS6KA10.42234546
110MAP2K10.42038734
111STK380.40264946
112PASK0.39839922
113CASK0.39545554
114TAOK10.38509160
115CSNK1A1L0.38375830
116JAK10.38022350
117GSK3B0.37952385
118CDK70.37726819
119TBK10.37634087
120PRKCG0.37449347
121SGK30.37279279
122STK110.37068579
123AKT10.36649864
124UHMK10.36093758
125DYRK20.35782388
126NEK20.34024172
127MAPK100.33847864
128CAMK2G0.33785823
129JAK20.33299073
130MAPK90.33285109
131INSR0.32893700
132CSNK1D0.31905666
133PRKG20.31100683
134RPS6KC10.30029041
135RPS6KL10.30029041
136PRKCI0.29818194
137TESK10.28968156
138MAP3K30.27511651
139CHUK0.26347189
140MAP3K80.26195831

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.52488791
2Focal adhesion_Homo sapiens_hsa045102.14069926
3Notch signaling pathway_Homo sapiens_hsa043302.05129844
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.01277707
5Basal cell carcinoma_Homo sapiens_hsa052172.00971560
6Proteoglycans in cancer_Homo sapiens_hsa052051.83317815
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81496337
8Adherens junction_Homo sapiens_hsa045201.79480387
9Small cell lung cancer_Homo sapiens_hsa052221.78297462
10* Axon guidance_Homo sapiens_hsa043601.78012212
11Hippo signaling pathway_Homo sapiens_hsa043901.76968895
12Chronic myeloid leukemia_Homo sapiens_hsa052201.69269380
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67860177
14Dilated cardiomyopathy_Homo sapiens_hsa054141.63311196
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59568094
16Amoebiasis_Homo sapiens_hsa051461.58004471
17Hedgehog signaling pathway_Homo sapiens_hsa043401.56924133
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56869848
19MicroRNAs in cancer_Homo sapiens_hsa052061.49016030
20Dorso-ventral axis formation_Homo sapiens_hsa043201.47941369
21Renal cell carcinoma_Homo sapiens_hsa052111.45887762
22Viral myocarditis_Homo sapiens_hsa054161.45306552
23Endometrial cancer_Homo sapiens_hsa052131.42775162
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39844079
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38078271
26Colorectal cancer_Homo sapiens_hsa052101.36361263
27Toxoplasmosis_Homo sapiens_hsa051451.35920883
28Estrogen signaling pathway_Homo sapiens_hsa049151.29856992
29VEGF signaling pathway_Homo sapiens_hsa043701.25907240
30Nicotine addiction_Homo sapiens_hsa050331.21819419
31Tight junction_Homo sapiens_hsa045301.21338262
32Pancreatic cancer_Homo sapiens_hsa052121.19964645
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19549589
34Glioma_Homo sapiens_hsa052141.19084168
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18083010
36Protein digestion and absorption_Homo sapiens_hsa049741.17594856
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.17522967
38mTOR signaling pathway_Homo sapiens_hsa041501.16188724
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.16142040
40Bladder cancer_Homo sapiens_hsa052191.15424602
41Sulfur relay system_Homo sapiens_hsa041221.15320417
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11078926
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10968447
44Thyroid cancer_Homo sapiens_hsa052161.10528426
45Rap1 signaling pathway_Homo sapiens_hsa040151.10015231
46Pathways in cancer_Homo sapiens_hsa052001.09281228
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08749943
48Melanogenesis_Homo sapiens_hsa049161.08037332
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.07774365
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05174274
51Glutamatergic synapse_Homo sapiens_hsa047241.03567233
52Insulin resistance_Homo sapiens_hsa049311.01908143
53Wnt signaling pathway_Homo sapiens_hsa043101.00749795
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98649828
55Osteoclast differentiation_Homo sapiens_hsa043800.97589897
56TGF-beta signaling pathway_Homo sapiens_hsa043500.96721295
57Type II diabetes mellitus_Homo sapiens_hsa049300.95765695
58Prolactin signaling pathway_Homo sapiens_hsa049170.95365508
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94498303
60TNF signaling pathway_Homo sapiens_hsa046680.92761206
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92503982
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92090407
63Cholinergic synapse_Homo sapiens_hsa047250.92041034
64Non-small cell lung cancer_Homo sapiens_hsa052230.91248854
65Inositol phosphate metabolism_Homo sapiens_hsa005620.90755703
66Lysine degradation_Homo sapiens_hsa003100.88677633
67ErbB signaling pathway_Homo sapiens_hsa040120.88622425
68HTLV-I infection_Homo sapiens_hsa051660.88579812
69Gap junction_Homo sapiens_hsa045400.87520971
70Platelet activation_Homo sapiens_hsa046110.87050204
71Insulin secretion_Homo sapiens_hsa049110.86899295
72Prostate cancer_Homo sapiens_hsa052150.85885107
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83480891
74GnRH signaling pathway_Homo sapiens_hsa049120.82945906
75Synaptic vesicle cycle_Homo sapiens_hsa047210.82314236
76ABC transporters_Homo sapiens_hsa020100.82194911
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81959525
78Long-term depression_Homo sapiens_hsa047300.81327868
79Endocytosis_Homo sapiens_hsa041440.81004507
80Cocaine addiction_Homo sapiens_hsa050300.80784352
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.80730536
82Circadian entrainment_Homo sapiens_hsa047130.80618336
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79722611
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79465368
85Melanoma_Homo sapiens_hsa052180.78027286
86Prion diseases_Homo sapiens_hsa050200.77899697
87Thyroid hormone synthesis_Homo sapiens_hsa049180.77535685
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76468945
89Long-term potentiation_Homo sapiens_hsa047200.76071807
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75720458
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74331714
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74197262
93HIF-1 signaling pathway_Homo sapiens_hsa040660.73880594
94Insulin signaling pathway_Homo sapiens_hsa049100.73550864
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73090609
96Bile secretion_Homo sapiens_hsa049760.72815539
97MAPK signaling pathway_Homo sapiens_hsa040100.72660424
98Ovarian steroidogenesis_Homo sapiens_hsa049130.71900491
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71719536
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70926780
101Acute myeloid leukemia_Homo sapiens_hsa052210.70854500
102Morphine addiction_Homo sapiens_hsa050320.70047869
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69599911
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69150783
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.68150016
106cAMP signaling pathway_Homo sapiens_hsa040240.67354818
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66586160
108Salmonella infection_Homo sapiens_hsa051320.66200099
109Ras signaling pathway_Homo sapiens_hsa040140.66001370
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65739803
111AMPK signaling pathway_Homo sapiens_hsa041520.63861343
112Oxytocin signaling pathway_Homo sapiens_hsa049210.63827777
113FoxO signaling pathway_Homo sapiens_hsa040680.63671625
114Apoptosis_Homo sapiens_hsa042100.63079330
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62756226
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61239698
117Malaria_Homo sapiens_hsa051440.59921131
118Shigellosis_Homo sapiens_hsa051310.59593030
119Other glycan degradation_Homo sapiens_hsa005110.59294376
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.59266705
121Vitamin B6 metabolism_Homo sapiens_hsa007500.59165052
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.59048130
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.58418369
124Hepatitis B_Homo sapiens_hsa051610.57966628
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56594793
126Gastric acid secretion_Homo sapiens_hsa049710.55051196
127Leishmaniasis_Homo sapiens_hsa051400.54365836
128Renin secretion_Homo sapiens_hsa049240.52730894
129Choline metabolism in cancer_Homo sapiens_hsa052310.51663068
130Chemokine signaling pathway_Homo sapiens_hsa040620.49037682
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47888367

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