SEMA3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.09855859
2limb bud formation (GO:0060174)4.21647671
3anterior/posterior axis specification, embryo (GO:0008595)4.11446565
4chondrocyte development (GO:0002063)4.10423659
5regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.02618884
6regulation of cell proliferation involved in kidney development (GO:1901722)3.94751193
7fatty acid elongation (GO:0030497)3.93289245
8atrioventricular valve morphogenesis (GO:0003181)3.91397692
9negative regulation of axon extension involved in axon guidance (GO:0048843)3.86747692
10long-chain fatty acid biosynthetic process (GO:0042759)3.84341945
11artery development (GO:0060840)3.83928670
12axon extension involved in axon guidance (GO:0048846)3.80046623
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.80046623
14paraxial mesoderm development (GO:0048339)3.72809351
15collagen fibril organization (GO:0030199)3.71442410
16lymphangiogenesis (GO:0001946)3.69738077
17regulation of hippo signaling (GO:0035330)3.66512782
18hemidesmosome assembly (GO:0031581)3.61728765
19axon ensheathment in central nervous system (GO:0032291)3.54828020
20central nervous system myelination (GO:0022010)3.54828020
21heart valve morphogenesis (GO:0003179)3.54443382
22peripheral nervous system axon ensheathment (GO:0032292)3.49090840
23myelination in peripheral nervous system (GO:0022011)3.49090840
24chondrocyte proliferation (GO:0035988)3.48964015
25keratinocyte proliferation (GO:0043616)3.48018237
26endocardial cushion morphogenesis (GO:0003203)3.47880171
27mesenchyme morphogenesis (GO:0072132)3.46755926
28regulation of phospholipase A2 activity (GO:0032429)3.45216181
29hippo signaling (GO:0035329)3.44695671
30myelination (GO:0042552)3.42607414
31negative regulation of axon guidance (GO:1902668)3.41836845
32regulation of glomerulus development (GO:0090192)3.38166636
33axon ensheathment (GO:0008366)3.34088852
34ensheathment of neurons (GO:0007272)3.34088852
35regulation of cardioblast differentiation (GO:0051890)3.33211342
36sphingoid metabolic process (GO:0046519)3.32789747
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.32150945
38positive regulation of actin filament depolymerization (GO:0030836)3.30083525
39smooth muscle tissue development (GO:0048745)3.25863890
40lateral sprouting from an epithelium (GO:0060601)3.22130993
41bone trabecula formation (GO:0060346)3.22049622
42mesenchymal-epithelial cell signaling (GO:0060638)3.20397475
43nephron tubule formation (GO:0072079)3.19981968
44sequestering of extracellular ligand from receptor (GO:0035581)3.17857974
45wound healing, spreading of epidermal cells (GO:0035313)3.15332073
46cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10694871
47organ induction (GO:0001759)3.10425506
48mesonephros development (GO:0001823)3.10151286
49negative chemotaxis (GO:0050919)3.06389334
50retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06385036
51sphingosine metabolic process (GO:0006670)3.05258168
52cell migration involved in sprouting angiogenesis (GO:0002042)3.04937904
53regulation of axon extension involved in axon guidance (GO:0048841)3.02477442
54positive regulation of cartilage development (GO:0061036)2.99048383
55cell proliferation involved in kidney development (GO:0072111)2.97980352
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.97677725
57regulation of organ formation (GO:0003156)2.94782575
58establishment of tissue polarity (GO:0007164)2.92579990
59establishment of planar polarity (GO:0001736)2.92579990
60endocardial cushion development (GO:0003197)2.92553842
61negative regulation of chondrocyte differentiation (GO:0032331)2.92151354
62protein heterotrimerization (GO:0070208)2.89969114
63cell adhesion mediated by integrin (GO:0033627)2.88576847
64type B pancreatic cell proliferation (GO:0044342)2.87284322
65ventricular septum development (GO:0003281)2.84594455
66regulation of axon guidance (GO:1902667)2.83331629
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81626959
68prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.79956121
69response to BMP (GO:0071772)2.78788041
70cellular response to BMP stimulus (GO:0071773)2.78788041
71virion attachment to host cell (GO:0019062)2.78235674
72adhesion of symbiont to host cell (GO:0044650)2.78235674
73pericardium development (GO:0060039)2.77586195
74positive regulation of catenin import into nucleus (GO:0035413)2.77395475
75oligodendrocyte differentiation (GO:0048709)2.77371972
76thyroid hormone generation (GO:0006590)2.76914970
77embryonic skeletal joint morphogenesis (GO:0060272)2.76286972
78regulation of cardioblast proliferation (GO:0003264)2.76270476
79regulation of secondary heart field cardioblast proliferation (GO:0003266)2.76270476
80mesenchymal cell differentiation involved in kidney development (GO:0072161)2.75401809
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.75401809
82cardiac epithelial to mesenchymal transition (GO:0060317)2.75070762
83response to gravity (GO:0009629)2.74412147
84cholesterol biosynthetic process (GO:0006695)2.73853381
85cartilage condensation (GO:0001502)2.72769836
86cell aggregation (GO:0098743)2.72769836
87interleukin-6-mediated signaling pathway (GO:0070102)2.71618742
88establishment of skin barrier (GO:0061436)2.70433420
89negative regulation of axon extension (GO:0030517)2.69134968
90lung-associated mesenchyme development (GO:0060484)2.66923124
91metanephric mesenchyme development (GO:0072075)2.66206609
92negative regulation of kidney development (GO:0090185)2.65258208
93negative regulation of fatty acid transport (GO:2000192)2.64651463
94regulation of water loss via skin (GO:0033561)2.64202360
95negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.63873554
96embryonic cranial skeleton morphogenesis (GO:0048701)2.63456860
97uronic acid metabolic process (GO:0006063)2.63223616
98glucuronate metabolic process (GO:0019585)2.63223616
99cellular glucuronidation (GO:0052695)2.63058993
100regulation of mesonephros development (GO:0061217)2.62536993
101embryonic foregut morphogenesis (GO:0048617)2.61154563
102diol metabolic process (GO:0034311)2.59345688
103regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.59338845
104nucleotide transmembrane transport (GO:1901679)2.58360783
105kidney mesenchyme development (GO:0072074)2.57302715
106substrate adhesion-dependent cell spreading (GO:0034446)2.57092448
107collagen catabolic process (GO:0030574)2.56763995
108mesenchymal cell proliferation (GO:0010463)2.56649506
109head development (GO:0060322)2.55666011
110mesenchyme development (GO:0060485)2.55299912
111keratinocyte differentiation (GO:0030216)2.55092721
112collagen metabolic process (GO:0032963)2.55028868
113outer ear morphogenesis (GO:0042473)2.54912712
114dermatan sulfate biosynthetic process (GO:0030208)2.54779341
115regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.54468580
116thyroid hormone metabolic process (GO:0042403)2.53329822
117cornea development in camera-type eye (GO:0061303)2.52949784
118endothelial cell morphogenesis (GO:0001886)2.52422604
119negative regulation of protein localization to cell surface (GO:2000009)2.52054119
120cochlea morphogenesis (GO:0090103)2.51729539
121negative regulation of keratinocyte proliferation (GO:0010839)2.51061710
122atrial septum morphogenesis (GO:0060413)2.49300348
123regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.49227260
124ear development (GO:0043583)2.49072294
125asymmetric protein localization (GO:0008105)2.47554790
126cranial suture morphogenesis (GO:0060363)2.47303796
127gland morphogenesis (GO:0022612)2.47012428
128neural crest cell development (GO:0014032)2.46577146
129embryonic forelimb morphogenesis (GO:0035115)2.46425280
130membrane assembly (GO:0071709)2.45629332
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.45284198
132endodermal cell differentiation (GO:0035987)2.45082800
133glomerular basement membrane development (GO:0032836)2.44224587
134regulation of keratinocyte proliferation (GO:0010837)2.44097093
135negative regulation of myoblast differentiation (GO:0045662)2.43853775
136polarized epithelial cell differentiation (GO:0030859)2.43400719
137glomerular filtration (GO:0003094)2.43395500
138regulation of heart morphogenesis (GO:2000826)2.43178678
139regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43137266
140mesenchymal cell development (GO:0014031)2.42804029
141eyelid development in camera-type eye (GO:0061029)2.42774742
142notochord development (GO:0030903)2.42447593
143regulation of transforming growth factor beta2 production (GO:0032909)2.41248339
144multicellular organismal macromolecule metabolic process (GO:0044259)2.40671374
145glomerulus development (GO:0032835)2.39919901
146negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39696083
147sterol biosynthetic process (GO:0016126)2.39474159
148positive regulation of mesenchymal cell proliferation (GO:0002053)2.38428646
149cell migration involved in heart development (GO:0060973)2.38409138
150cardiac right ventricle morphogenesis (GO:0003215)2.38316640
151positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.37984127
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37956448
153outflow tract septum morphogenesis (GO:0003148)2.37775258
154negative regulation of cardiac muscle tissue development (GO:0055026)2.37600517
155dermatan sulfate metabolic process (GO:0030205)2.37157401
156regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.36529001
157wound healing, spreading of cells (GO:0044319)2.35963855
158heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.33865154
159regulation of mesenchymal cell proliferation (GO:0010464)2.33251483
160positive regulation of cardiac muscle tissue development (GO:0055025)2.33228013
161regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32931419
162multicellular organismal catabolic process (GO:0044243)2.32793361
163UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32224200
164multicellular organismal metabolic process (GO:0044236)2.31750073
165branching involved in salivary gland morphogenesis (GO:0060445)2.30630752
166cardiac septum development (GO:0003279)2.29739957
167Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29722826
168branching involved in ureteric bud morphogenesis (GO:0001658)2.29512710
169DNA damage induced protein phosphorylation (GO:0006975)2.29139138
170positive regulation of male gonad development (GO:2000020)2.29137651
171regulation of cardiac muscle tissue development (GO:0055024)2.28985993
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28528560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.93001358
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.48470337
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31848467
4AR_21572438_ChIP-Seq_LNCaP_Human2.65654436
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.47837902
6* EED_16625203_ChIP-ChIP_MESCs_Mouse2.35645186
7EZH2_22144423_ChIP-Seq_EOC_Human2.29645762
8GBX2_23144817_ChIP-Seq_PC3_Human2.22586285
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.15821525
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10502075
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99178713
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98886777
13RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98355285
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94393734
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94091180
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94091180
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92274599
18* EWS_26573619_Chip-Seq_HEK293_Human1.91645474
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91035337
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.90149209
21* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89226480
22ZNF274_21170338_ChIP-Seq_K562_Hela1.89169711
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87939743
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87538482
25* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87205873
26TP53_18474530_ChIP-ChIP_U2OS_Human1.80852908
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80555421
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79074450
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78369153
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77526481
31IGF1R_20145208_ChIP-Seq_DFB_Human1.76388732
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75415383
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.73776495
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72636523
35* CJUN_26792858_Chip-Seq_BT549_Human1.68992626
36* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63413810
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.62925436
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.61368923
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60339983
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60339983
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59943404
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56358932
43TAF15_26573619_Chip-Seq_HEK293_Human1.55533378
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55221529
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.51998984
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51827639
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51319388
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.50899163
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49888287
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.47938634
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44511702
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44408085
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44406915
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41809960
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41359018
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.40543078
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40146363
58STAT3_23295773_ChIP-Seq_U87_Human1.38504722
59TBX3_20139965_ChIP-Seq_ESCs_Mouse1.38079768
60TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38004919
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36543403
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35939867
63TP53_16413492_ChIP-PET_HCT116_Human1.33762020
64AR_25329375_ChIP-Seq_VCAP_Human1.33427503
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32597790
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.31465461
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.30758950
68* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29633937
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.29032685
70* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28762230
71VDR_22108803_ChIP-Seq_LS180_Human1.28379063
72SOX2_20726797_ChIP-Seq_SW620_Human1.27972629
73* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27624246
74* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27250653
75* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27198865
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26888075
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26673559
78KDM2B_26808549_Chip-Seq_REH_Human1.25925656
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25083033
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.23165191
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20927319
82* FUS_26573619_Chip-Seq_HEK293_Human1.19876099
83* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19222389
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17722894
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17508390
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16099896
87TCF4_23295773_ChIP-Seq_U87_Human1.15712071
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.15351671
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14014736
90AHR_22903824_ChIP-Seq_MCF-7_Human1.13159799
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.12123545
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12111698
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11973656
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.11583197
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11284982
96CBP_20019798_ChIP-Seq_JUKART_Human1.11284982
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10375736
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10375736
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09778489
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.09248539
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08053785
102* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07849065
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07365145
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.06760953
105* P300_19829295_ChIP-Seq_ESCs_Human1.06300472
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06200699
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.05670677
108* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05397685
109TP63_23658742_ChIP-Seq_EP156T_Human1.05100046
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04464665
111* TCF4_22108803_ChIP-Seq_LS180_Human1.03863777
112* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01700758
113SMAD4_21799915_ChIP-Seq_A2780_Human1.00690247
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00259584
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.99832684
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.99284651
117RXR_22108803_ChIP-Seq_LS180_Human0.98052152
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96960842
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95693628
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95228619
121RNF2_27304074_Chip-Seq_NSC_Mouse0.94344629
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93061031
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92640052
124* ER_23166858_ChIP-Seq_MCF-7_Human0.91576872
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.91339099
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.90939467
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.89749471
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88461092
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88332708
130VDR_24787735_ChIP-Seq_THP-1_Human0.88106800
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87792731
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87176376
133* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87102095
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86881431
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86183036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.18408783
2MP0005503_abnormal_tendon_morphology3.90501657
3MP0005275_abnormal_skin_tensile3.55981075
4MP0009250_abnormal_appendicular_skeleto3.31401584
5MP0008438_abnormal_cutaneous_collagen3.29643223
6MP0000566_synostosis3.15368826
7MP0010030_abnormal_orbit_morphology2.74780203
8MP0000383_abnormal_hair_follicle2.70873256
9MP0000762_abnormal_tongue_morphology2.61487615
10MP0003385_abnormal_body_wall2.57765453
11MP0004134_abnormal_chest_morphology2.55911563
12MP0009384_cardiac_valve_regurgitation2.55270643
13MP0001346_abnormal_lacrimal_gland2.55178229
14MP0002796_impaired_skin_barrier2.52879826
15MP0004381_abnormal_hair_follicle2.39200323
16MP0004272_abnormal_basement_membrane2.37401810
17MP0002060_abnormal_skin_morphology2.26757647
18MP0006054_spinal_hemorrhage2.20378612
19MP0002249_abnormal_larynx_morphology2.15171024
20MP0010678_abnormal_skin_adnexa2.12511351
21MP0002102_abnormal_ear_morphology2.07909709
22MP0005508_abnormal_skeleton_morphology2.02483517
23MP0002254_reproductive_system_inflammat2.00491058
24MP0002282_abnormal_trachea_morphology1.94580031
25MP0000467_abnormal_esophagus_morphology1.87444932
26MP0000647_abnormal_sebaceous_gland1.82761956
27MP0000163_abnormal_cartilage_morphology1.79312276
28MP0002108_abnormal_muscle_morphology1.78538882
29MP0001299_abnormal_eye_distance/1.78375977
30MP0009379_abnormal_foot_pigmentation1.78191390
31MP0002233_abnormal_nose_morphology1.78122920
32MP0003937_abnormal_limbs/digits/tail_de1.71954300
33MP0003755_abnormal_palate_morphology1.71082275
34MP0005409_darkened_coat_color1.63487652
35MP0000534_abnormal_ureter_morphology1.61685567
36MP0000920_abnormal_myelination1.60419933
37MP0001879_abnormal_lymphatic_vessel1.60173071
38MP0003942_abnormal_urinary_system1.58664153
39MP0009053_abnormal_anal_canal1.55765877
40MP0003705_abnormal_hypodermis_morpholog1.53053595
41MP0001293_anophthalmia1.48515246
42MP0005595_abnormal_vascular_smooth1.46028771
43MP0001340_abnormal_eyelid_morphology1.45204084
44MP0005171_absent_coat_pigmentation1.44524628
45MP0000049_abnormal_middle_ear1.43793848
46MP0002098_abnormal_vibrissa_morphology1.43350001
47MP0003136_yellow_coat_color1.43252298
48MP0001216_abnormal_epidermal_layer1.43105631
49MP0002115_abnormal_skeleton_extremities1.42338613
50MP0010771_integument_phenotype1.41198077
51MP0002933_joint_inflammation1.40181676
52MP0003283_abnormal_digestive_organ1.39276601
53MP0008789_abnormal_olfactory_epithelium1.38322512
54MP0003453_abnormal_keratinocyte_physiol1.37086745
55MP0003938_abnormal_ear_development1.36482420
56MP0000579_abnormal_nail_morphology1.30896730
57MP0001542_abnormal_bone_strength1.29243226
58MP0003119_abnormal_digestive_system1.26362957
59MP0002109_abnormal_limb_morphology1.24961682
60MP0001958_emphysema1.24369080
61MP0002932_abnormal_joint_morphology1.21765467
62MP0003950_abnormal_plasma_membrane1.21277860
63MP0005501_abnormal_skin_physiology1.20568030
64MP0002697_abnormal_eye_size1.17900766
65MP0000427_abnormal_hair_cycle1.15900047
66MP0000013_abnormal_adipose_tissue1.14577592
67MP0000569_abnormal_digit_pigmentation1.14282317
68MP0000377_abnormal_hair_follicle1.14240587
69MP0002896_abnormal_bone_mineralization1.14112617
70MP0001177_atelectasis1.13719821
71MP0002177_abnormal_outer_ear1.12278029
72MP0002938_white_spotting1.11641703
73MP0002295_abnormal_pulmonary_circulatio1.11201414
74MP0004133_heterotaxia1.10829326
75MP0002113_abnormal_skeleton_development1.10584165
76MP0000733_abnormal_muscle_development1.10546686
77MP0005257_abnormal_intraocular_pressure1.10442469
78MP0001348_abnormal_lacrimal_gland1.10317424
79MP0003935_abnormal_craniofacial_develop1.08920105
80MP0000432_abnormal_head_morphology1.08760397
81MP0005187_abnormal_penis_morphology1.08627237
82MP0001286_abnormal_eye_development1.07915466
83MP0002116_abnormal_craniofacial_bone1.07791594
84MP0002009_preneoplasia1.07599238
85MP0005197_abnormal_uvea_morphology1.06706730
86MP0000462_abnormal_digestive_system1.06020543
87MP0001243_abnormal_dermal_layer1.05649487
88MP0005451_abnormal_body_composition1.04921804
89MP0002234_abnormal_pharynx_morphology1.03854254
90MP0005390_skeleton_phenotype1.02147122
91MP0001270_distended_abdomen1.01918256
92MP0005367_renal/urinary_system_phenotyp0.98106475
93MP0000516_abnormal_urinary_system0.98106475
94MP0003011_delayed_dark_adaptation0.97159888
95MP0002111_abnormal_tail_morphology0.96718866
96MP0002160_abnormal_reproductive_system0.95849147
97MP0009780_abnormal_chondrocyte_physiolo0.95125382
98MP0010352_gastrointestinal_tract_polyps0.95038955
99MP0001851_eye_inflammation0.94840490
100MP0006072_abnormal_retinal_apoptosis0.94157242
101MP0002114_abnormal_axial_skeleton0.91428584
102MP0000428_abnormal_craniofacial_morphol0.90331156
103MP0002133_abnormal_respiratory_system0.89854394
104MP0005388_respiratory_system_phenotype0.89854394
105MP0006276_abnormal_autonomic_nervous0.89508926
106MP0002092_abnormal_eye_morphology0.89026863
107MP0000678_abnormal_parathyroid_gland0.88572175
108MP0000537_abnormal_urethra_morphology0.88231845
109MP0003115_abnormal_respiratory_system0.87897491
110MP0003566_abnormal_cell_adhesion0.87738251
111MP0005167_abnormal_blood-brain_barrier0.87455866
112MP0005623_abnormal_meninges_morphology0.82595871
113MP0005023_abnormal_wound_healing0.81583592
114MP0000613_abnormal_salivary_gland0.80933845
115MP0002084_abnormal_developmental_patter0.79490745
116MP0004742_abnormal_vestibular_system0.78799136
117MP0002876_abnormal_thyroid_physiology0.77784201
118MP0000538_abnormal_urinary_bladder0.77731364
119MP0010386_abnormal_urinary_bladder0.77599048
120MP0004185_abnormal_adipocyte_glucose0.77125714
121MP0003279_aneurysm0.76834109
122MP0003890_abnormal_embryonic-extraembry0.76263103
123MP0005499_abnormal_olfactory_system0.75557631
124MP0005394_taste/olfaction_phenotype0.75557631
125MP0006138_congestive_heart_failure0.74807883
126MP0005391_vision/eye_phenotype0.74267035
127MP0000767_abnormal_smooth_muscle0.73927817
128MP0003828_pulmonary_edema0.72861754
129MP0010368_abnormal_lymphatic_system0.72150990
130MP0000778_abnormal_nervous_system0.71689748
131MP0005248_abnormal_Harderian_gland0.71343839
132MP0002127_abnormal_cardiovascular_syste0.68218855
133MP0000230_abnormal_systemic_arterial0.67958191
134MP0002128_abnormal_blood_circulation0.67423132
135MP0002925_abnormal_cardiovascular_devel0.66703152
136MP0005620_abnormal_muscle_contractility0.66418929
137MP0002751_abnormal_autonomic_nervous0.63885106
138MP0008775_abnormal_heart_ventricle0.63534582
139MP0004885_abnormal_endolymph0.62412878

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.48412877
2Aortic dissection (HP:0002647)4.42096050
3Irregular epiphyses (HP:0010582)4.32576623
4Hypoplastic ischia (HP:0003175)4.00174050
5Soft skin (HP:0000977)3.96392855
6Abnormality of the phalanges of the 2nd finger (HP:0009541)3.95260084
7Small epiphyses (HP:0010585)3.88516729
8Vitreoretinal degeneration (HP:0000655)3.80545702
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.79679044
10Lip pit (HP:0100267)3.61021444
11Abnormality of the ischium (HP:0003174)3.57745437
12Parakeratosis (HP:0001036)3.56301566
13Cupped ribs (HP:0000887)3.48130208
14Aortic aneurysm (HP:0004942)3.46553368
15Premature rupture of membranes (HP:0001788)3.34278446
16Abnormality of the 2nd finger (HP:0004100)3.25035350
17Bladder diverticulum (HP:0000015)3.20540721
18Broad metatarsal (HP:0001783)3.16580369
19Neonatal short-limb short stature (HP:0008921)3.01619181
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01017142
21Abnormality of incisor morphology (HP:0011063)2.97592171
22Delayed epiphyseal ossification (HP:0002663)2.91795916
23Atrophic scars (HP:0001075)2.91083777
24Vascular tortuosity (HP:0004948)2.89104862
25Bilateral microphthalmos (HP:0007633)2.83263552
26Abnormal tarsal ossification (HP:0008369)2.80104778
27Popliteal pterygium (HP:0009756)2.79594473
28Increased corneal curvature (HP:0100692)2.75026893
29Keratoconus (HP:0000563)2.75026893
30Shallow orbits (HP:0000586)2.71210029
31Enlarged epiphyses (HP:0010580)2.57855144
32Limited hip movement (HP:0008800)2.57325731
33Arterial tortuosity (HP:0005116)2.56570427
34Osteoarthritis (HP:0002758)2.50940729
35Mild short stature (HP:0003502)2.49977475
36Right ventricular cardiomyopathy (HP:0011663)2.48928616
37Aplasia involving bones of the extremities (HP:0009825)2.47274164
38Aplasia involving bones of the upper limbs (HP:0009823)2.47274164
39Aplasia of the phalanges of the hand (HP:0009802)2.47274164
40Cutaneous syndactyly (HP:0012725)2.45231662
41Metaphyseal dysplasia (HP:0100255)2.41732251
42Congenital ichthyosiform erythroderma (HP:0007431)2.41193480
43Abnormality of the middle phalanges of the toes (HP:0010183)2.40520266
44Genu varum (HP:0002970)2.38477188
45Pterygium (HP:0001059)2.38398366
46Morphological abnormality of the middle ear (HP:0008609)2.38261455
47Bifid tongue (HP:0010297)2.35298671
48Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.35134868
49Bifid scrotum (HP:0000048)2.34968577
50Flat acetabular roof (HP:0003180)2.34796447
51Abnormality of the phalanges of the 5th finger (HP:0004213)2.33668077
52Abnormality of the pubic bones (HP:0003172)2.33193640
53Cervical subluxation (HP:0003308)2.30847583
54Mitral valve prolapse (HP:0001634)2.30120081
55Cupped ear (HP:0000378)2.29184078
56Aplasia of the musculature (HP:0100854)2.29002727
57Natal tooth (HP:0000695)2.26210543
58Adrenal hypoplasia (HP:0000835)2.25942999
59Mixed hearing impairment (HP:0000410)2.24038210
60Pulmonary artery stenosis (HP:0004415)2.23763546
61Abnormality of carpal bone ossification (HP:0006257)2.22871661
62Protrusio acetabuli (HP:0003179)2.20908767
63Thyroid-stimulating hormone excess (HP:0002925)2.19988935
64Hip contracture (HP:0003273)2.18261802
65Ankle contracture (HP:0006466)2.18096324
66Abnormal foot bone ossification (HP:0010675)2.17819755
67Metaphyseal irregularity (HP:0003025)2.15545020
68Wormian bones (HP:0002645)2.15507283
69Synostosis involving the elbow (HP:0003938)2.15016325
70Humeroradial synostosis (HP:0003041)2.15016325
71Down-sloping shoulders (HP:0200021)2.13786315
72Genu recurvatum (HP:0002816)2.12856725
73Follicular hyperkeratosis (HP:0007502)2.12546185
74Midline defect of the nose (HP:0004122)2.10544171
75Hypoplastic pelvis (HP:0008839)2.08363316
76Asymmetry of the thorax (HP:0001555)2.08211938
77Mesomelia (HP:0003027)2.05337345
78Peritonitis (HP:0002586)2.04238764
79Hyperextensible skin (HP:0000974)2.02331982
80Bowel diverticulosis (HP:0005222)2.02319010
81Hypotrichosis (HP:0001006)2.01208410
82Bicornuate uterus (HP:0000813)2.00866987
83Femoral bowing (HP:0002980)2.00522416
84Symphalangism affecting the phalanges of the hand (HP:0009773)2.00521890
85Bell-shaped thorax (HP:0001591)1.99936556
86Nasolacrimal duct obstruction (HP:0000579)1.98976332
87Chin dimple (HP:0010751)1.98775690
88Abnormality of the nasolacrimal system (HP:0000614)1.98278587
89Akinesia (HP:0002304)1.98120652
90Short 4th metacarpal (HP:0010044)1.97731509
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97731509
92Anomalous pulmonary venous return (HP:0010772)1.97552604
93Long clavicles (HP:0000890)1.94215377
94Sensory axonal neuropathy (HP:0003390)1.92918935
95Blue sclerae (HP:0000592)1.92177204
96Severe Myopia (HP:0011003)1.91760858
97Fibular hypoplasia (HP:0003038)1.91318567
98Wide anterior fontanel (HP:0000260)1.90780299
99Ulnar bowing (HP:0003031)1.90161174
100Abnormal vertebral ossification (HP:0100569)1.90115317
101Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90104690
102Thin ribs (HP:0000883)1.90095955
103Premature skin wrinkling (HP:0100678)1.89962217
104White forelock (HP:0002211)1.89737158
105Abnormality of dentin (HP:0010299)1.88111436
106Cutaneous finger syndactyly (HP:0010554)1.87730854
107Coronal craniosynostosis (HP:0004440)1.87669497
108Short hallux (HP:0010109)1.87513460
109Aortic valve stenosis (HP:0001650)1.87314040
110Chorioretinal atrophy (HP:0000533)1.87291431
111Broad ribs (HP:0000885)1.86509871
112Thick nail (HP:0001805)1.86041268
113Distal arthrogryposis (HP:0005684)1.85502703
114Partial duplication of the phalanx of hand (HP:0009999)1.85190548
115Abnormality of the lacrimal duct (HP:0011481)1.84257785
116Flat capital femoral epiphysis (HP:0003370)1.83857610
117Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83784210
118Fetal akinesia sequence (HP:0001989)1.83493945
119Knee flexion contracture (HP:0006380)1.83274383
120Striae distensae (HP:0001065)1.82620435
121Abnormality of the axillary hair (HP:0100134)1.81952012
122Abnormality of secondary sexual hair (HP:0009888)1.81952012
123Anophthalmia (HP:0000528)1.81583300
124Preaxial foot polydactyly (HP:0001841)1.81507113
125Fragile skin (HP:0001030)1.80660589
126Aplasia cutis congenita (HP:0001057)1.80032370
127Abnormal hand bone ossification (HP:0010660)1.79969707
128Abnormality of the pulmonary veins (HP:0011718)1.78860094
129Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78743491
130Abnormality of femoral epiphyses (HP:0006499)1.78743491
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78654120
132Absent epiphyses (HP:0010577)1.78654120
133Synostosis of carpal bones (HP:0005048)1.78212847
134Absent frontal sinuses (HP:0002688)1.78154598
135Vertebral clefting (HP:0008428)1.77979940
136Overgrowth (HP:0001548)1.77710720
137Infantile muscular hypotonia (HP:0008947)1.74094112
138Pancreatic fibrosis (HP:0100732)1.73822780
139Pancreatic cysts (HP:0001737)1.72628818
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.72255645
141Aortic regurgitation (HP:0001659)1.71683519
142Broad long bones (HP:0005622)1.67992302
143Tarsal synostosis (HP:0008368)1.65006442
144True hermaphroditism (HP:0010459)1.64013125
145Increased number of teeth (HP:0011069)1.63493263
146Tubular atrophy (HP:0000092)1.63399922
147Tracheal stenosis (HP:0002777)1.63254541
148Absent eyelashes (HP:0000561)1.63004873
149Deviation of the hallux (HP:0010051)1.60772751
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.59327973
151Genetic anticipation (HP:0003743)1.58770653
152Ectopia lentis (HP:0001083)1.58630414
153Abnormal delivery (HP:0001787)1.57502837
154Flat face (HP:0012368)1.55911371
155Congenital sensorineural hearing impairment (HP:0008527)1.55695426
156Renovascular hypertension (HP:0100817)1.55236374
157Round ear (HP:0100830)1.54982817
158Dilatation of the ascending aorta (HP:0005111)1.54928899
159Synostosis involving bones of the lower limbs (HP:0009138)1.53423113
160Synostosis involving bones of the feet (HP:0009140)1.53423113
161Absent eyebrow (HP:0002223)1.52040661
162Inguinal hernia (HP:0000023)1.52036035
163Joint laxity (HP:0001388)1.51514903
164Breech presentation (HP:0001623)1.50253879
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.49132449
166Camptodactyly of toe (HP:0001836)1.47521440
167Sprengel anomaly (HP:0000912)1.47270765
168Myelomeningocele (HP:0002475)1.47212527
169Vaginal atresia (HP:0000148)1.47033790
170Genital tract atresia (HP:0001827)1.46791628
171Abnormality of midbrain morphology (HP:0002418)1.46709994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.15226272
2STK393.59780758
3AKT33.24607351
4MYLK3.23710966
5DDR23.09028867
6CASK3.06884709
7MST42.73353813
8OXSR12.53510833
9ERBB32.47810473
10BCR2.45867925
11TIE12.43312340
12BRD42.42948294
13MET2.35091870
14MAP3K32.24836027
15EPHB22.23094757
16MST1R2.16541380
17PBK2.08978295
18EPHA32.07189099
19TRPM72.05426789
20MAPKAPK52.04824123
21EPHB12.01195191
22FGFR21.85332083
23PTK2B1.72144864
24NEK61.71704500
25ADRBK21.66208694
26LATS11.65289098
27LIMK11.61281287
28WNK11.57968508
29TGFBR11.57865349
30WNK31.47816949
31STK241.47610521
32WNK41.41173669
33STK381.39966004
34MKNK11.39682543
35LATS21.36825799
36CDK191.27998401
37TYRO31.26439573
38PIK3CA1.24398547
39PDGFRB1.22604081
40TLK11.21859873
41ROCK21.21091619
42BMPR1B1.21090573
43BRSK21.19009936
44NEK91.18218317
45MAPK151.17347466
46PNCK1.16978751
47MUSK1.16054374
48FER1.15117987
49PAK31.13656240
50STK38L1.07743803
51MAP4K21.07279649
52NUAK11.07024428
53ERBB41.04808026
54ROCK11.04770388
55ADRBK11.01778109
56PKN11.00009133
57GRK70.99105351
58MOS0.95635122
59DMPK0.91379832
60MAP3K20.90903044
61EPHA20.90066352
62PIM20.88916037
63PIK3CG0.87624449
64PRPF4B0.84929841
65CSNK1A1L0.84117991
66FRK0.84027209
67ACVR1B0.82642749
68PINK10.78025919
69PTK20.77777009
70FLT30.75656211
71MAPK70.73310800
72MKNK20.69734833
73MELK0.69215248
74RPS6KB20.68287936
75ILK0.67321818
76BMPR20.67012689
77ERBB20.66875536
78ZAK0.66231603
79OBSCN0.65268265
80CSNK1G10.63754553
81PRKCE0.62298465
82TGFBR20.60766025
83EPHA40.60307360
84TTN0.60303608
85INSRR0.59178992
86TRIM280.59085862
87PRKCG0.58178069
88PAK20.55819445
89PTK60.55138817
90WEE10.55128425
91SIK10.54189298
92RPS6KA20.52337929
93MAP2K10.51786938
94PDGFRA0.51599085
95CLK10.50796103
96BRSK10.50057492
97MARK10.49960305
98CAMK2D0.49285785
99GRK10.48622613
100IRAK10.48585063
101STK30.48477381
102PRKCQ0.48019545
103RIPK10.47832887
104CSNK1G30.47615738
105MAP3K40.47122387
106GSK3A0.46343095
107CHEK20.46119807
108PRKG10.45813519
109TAOK20.42868083
110PLK20.42495615
111IRAK20.42171672
112STK100.41692453
113DYRK1A0.40775693
114NEK20.40707871
115CDK80.40600657
116PRKD20.40357791
117ICK0.39912298
118NTRK10.39593976
119EIF2AK20.39426617
120MAPK130.39238488
121MAP2K60.38447582
122INSR0.38447072
123CDK30.37950217
124PRKD10.37614732
125MAPKAPK30.37489099
126TAF10.36543554
127PLK10.36540105
128CSNK1D0.36438194
129PRKCH0.36053013
130FES0.35592968
131MTOR0.34895421
132ABL10.34749197
133SIK30.34713800
134SRC0.34397913
135MARK20.34212158
136PLK30.32618351
137CAMK2A0.31628930
138FGFR10.31622365
139LRRK20.31452768
140IGF1R0.31206560
141DAPK30.30803214
142FYN0.30433166
143CAMK2B0.28901543
144RPS6KA60.26805811
145PRKG20.26742918

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.45190803
2ECM-receptor interaction_Homo sapiens_hsa045123.41457181
3Sphingolipid metabolism_Homo sapiens_hsa006003.00622413
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.91346655
5* Axon guidance_Homo sapiens_hsa043602.40919844
6Fatty acid elongation_Homo sapiens_hsa000622.28057659
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24546705
8Protein digestion and absorption_Homo sapiens_hsa049742.10638232
9Ether lipid metabolism_Homo sapiens_hsa005651.96396700
10Basal cell carcinoma_Homo sapiens_hsa052171.95623805
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83670147
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81782159
13Arachidonic acid metabolism_Homo sapiens_hsa005901.80624476
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.75885657
15Focal adhesion_Homo sapiens_hsa045101.74302735
16Hedgehog signaling pathway_Homo sapiens_hsa043401.73471385
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72865657
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69352506
19Sulfur metabolism_Homo sapiens_hsa009201.65003428
20Hippo signaling pathway_Homo sapiens_hsa043901.63090927
21TGF-beta signaling pathway_Homo sapiens_hsa043501.61628384
22Thyroid hormone synthesis_Homo sapiens_hsa049181.60816033
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58842720
24Selenocompound metabolism_Homo sapiens_hsa004501.54874523
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52164156
26Phototransduction_Homo sapiens_hsa047441.50580202
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49073575
28Tight junction_Homo sapiens_hsa045301.42335925
29Retinol metabolism_Homo sapiens_hsa008301.40106425
30Linoleic acid metabolism_Homo sapiens_hsa005911.35884819
31Chemical carcinogenesis_Homo sapiens_hsa052041.34884246
32Malaria_Homo sapiens_hsa051441.33217794
33Proteoglycans in cancer_Homo sapiens_hsa052051.28529640
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27895009
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25265813
36Dilated cardiomyopathy_Homo sapiens_hsa054141.23567339
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18747614
38Glutathione metabolism_Homo sapiens_hsa004801.18394798
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17783378
40Ovarian steroidogenesis_Homo sapiens_hsa049131.17176637
41Adherens junction_Homo sapiens_hsa045201.16688495
42MicroRNAs in cancer_Homo sapiens_hsa052061.13508038
43Dorso-ventral axis formation_Homo sapiens_hsa043201.12417181
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09565505
45Wnt signaling pathway_Homo sapiens_hsa043101.04174265
46Prostate cancer_Homo sapiens_hsa052151.02076110
47Serotonergic synapse_Homo sapiens_hsa047261.01285780
48Long-term depression_Homo sapiens_hsa047300.99208735
49Salivary secretion_Homo sapiens_hsa049700.98057773
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96201627
51Taste transduction_Homo sapiens_hsa047420.93153452
52Calcium signaling pathway_Homo sapiens_hsa040200.92715548
53Gastric acid secretion_Homo sapiens_hsa049710.91379463
54Amoebiasis_Homo sapiens_hsa051460.90367348
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.89067334
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88857606
57Renin-angiotensin system_Homo sapiens_hsa046140.88196136
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.87066328
59p53 signaling pathway_Homo sapiens_hsa041150.86265494
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86036594
61Circadian entrainment_Homo sapiens_hsa047130.84057914
62Renal cell carcinoma_Homo sapiens_hsa052110.83977549
63Basal transcription factors_Homo sapiens_hsa030220.82634667
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82454476
65Insulin secretion_Homo sapiens_hsa049110.81937340
66Protein export_Homo sapiens_hsa030600.81605125
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81232170
68Ras signaling pathway_Homo sapiens_hsa040140.80688432
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80443671
70Olfactory transduction_Homo sapiens_hsa047400.79234839
71ABC transporters_Homo sapiens_hsa020100.77808525
72Rheumatoid arthritis_Homo sapiens_hsa053230.76680810
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75159900
74Melanogenesis_Homo sapiens_hsa049160.74772137
75Morphine addiction_Homo sapiens_hsa050320.73225960
76ErbB signaling pathway_Homo sapiens_hsa040120.73030667
77Melanoma_Homo sapiens_hsa052180.72292503
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71715713
79One carbon pool by folate_Homo sapiens_hsa006700.70657220
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70363232
81GABAergic synapse_Homo sapiens_hsa047270.69360702
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66913411
83Caffeine metabolism_Homo sapiens_hsa002320.66417145
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66270134
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64783904
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63935763
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63359125
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63055359
89Platelet activation_Homo sapiens_hsa046110.62178662
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.60648503
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59625637
92Non-homologous end-joining_Homo sapiens_hsa034500.56670792
93Fanconi anemia pathway_Homo sapiens_hsa034600.56451299
94Nicotine addiction_Homo sapiens_hsa050330.56069101
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.55947780
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.55864821
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55787292
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55066191
99N-Glycan biosynthesis_Homo sapiens_hsa005100.53619682
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53213966
101Phagosome_Homo sapiens_hsa041450.52605700
102Pathways in cancer_Homo sapiens_hsa052000.52463752
103Small cell lung cancer_Homo sapiens_hsa052220.52432097
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52099146
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.50388634
106Choline metabolism in cancer_Homo sapiens_hsa052310.49428528
107Notch signaling pathway_Homo sapiens_hsa043300.48790382
108Rap1 signaling pathway_Homo sapiens_hsa040150.48615808
109Gap junction_Homo sapiens_hsa045400.48226453
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47755577
111Dopaminergic synapse_Homo sapiens_hsa047280.47461914
112MAPK signaling pathway_Homo sapiens_hsa040100.47292668
113Bladder cancer_Homo sapiens_hsa052190.45271873
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45212016
115Vitamin digestion and absorption_Homo sapiens_hsa049770.44550238
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.44106347
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42957443
118Glutamatergic synapse_Homo sapiens_hsa047240.42158930
119Renin secretion_Homo sapiens_hsa049240.41884544
120GnRH signaling pathway_Homo sapiens_hsa049120.41204256
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38772597
122TNF signaling pathway_Homo sapiens_hsa046680.38734066
123Cholinergic synapse_Homo sapiens_hsa047250.38572173
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38475263
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36348862
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35623049
127Cocaine addiction_Homo sapiens_hsa050300.33944030
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33739103
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31889443
130Oxytocin signaling pathway_Homo sapiens_hsa049210.31788791
131Endocytosis_Homo sapiens_hsa041440.31631739
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30962631
133Salmonella infection_Homo sapiens_hsa051320.30841401
134Circadian rhythm_Homo sapiens_hsa047100.30552110
135Viral myocarditis_Homo sapiens_hsa054160.29058145
136Butanoate metabolism_Homo sapiens_hsa006500.28694170
137cAMP signaling pathway_Homo sapiens_hsa040240.28007454
138Pancreatic secretion_Homo sapiens_hsa049720.27635240

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