SELPLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.75798092
2positive regulation of gamma-delta T cell activation (GO:0046645)5.59205211
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.52418374
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.52418374
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.18791176
6negative regulation of cell killing (GO:0031342)5.18791176
7regulation of B cell receptor signaling pathway (GO:0050855)5.14694819
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.09706707
9antigen processing and presentation of endogenous antigen (GO:0019883)4.88688198
10detection of other organism (GO:0098543)4.74754824
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.73165175
12detection of bacterium (GO:0016045)4.64833158
13leukocyte aggregation (GO:0070486)4.48198316
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.40857391
15regulation of gamma-delta T cell differentiation (GO:0045586)4.30030006
16T cell migration (GO:0072678)4.26397729
17positive regulation of chemokine secretion (GO:0090197)4.23271698
18interferon-gamma production (GO:0032609)4.17876104
19negative T cell selection (GO:0043383)4.16787682
20cellular extravasation (GO:0045123)4.14987072
21negative thymic T cell selection (GO:0045060)4.09771165
22positive regulation of B cell differentiation (GO:0045579)4.03973420
23regulation of gamma-delta T cell activation (GO:0046643)4.02893222
24negative regulation of leukocyte mediated immunity (GO:0002704)3.97064236
25regulation of B cell differentiation (GO:0045577)3.96905860
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94612520
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.94612520
28modulation by symbiont of host immune response (GO:0052553)3.94612520
29positive regulation by symbiont of host defense response (GO:0052509)3.94612520
30modulation by symbiont of host defense response (GO:0052031)3.94612520
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94612520
32detection of external biotic stimulus (GO:0098581)3.91372491
33regulation of interferon-beta biosynthetic process (GO:0045357)3.91112476
34negative regulation of T cell mediated immunity (GO:0002710)3.90855181
35response to interleukin-15 (GO:0070672)3.84971751
36positive thymic T cell selection (GO:0045059)3.83315300
37tolerance induction (GO:0002507)3.82314064
38immunoglobulin mediated immune response (GO:0016064)3.82155265
39mast cell activation (GO:0045576)3.69839683
40cellular response to interleukin-15 (GO:0071350)3.68605008
41regulation of tolerance induction (GO:0002643)3.64967587
42negative regulation of granulocyte differentiation (GO:0030853)3.60664215
43neutrophil activation involved in immune response (GO:0002283)3.59611541
44leukocyte migration involved in inflammatory response (GO:0002523)3.56412119
45B cell receptor signaling pathway (GO:0050853)3.55502054
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52940485
47response to host immune response (GO:0052572)3.52940485
48negative regulation of phagocytosis (GO:0050765)3.52139295
49detection of molecule of bacterial origin (GO:0032490)3.48041358
50positive regulation of antigen processing and presentation (GO:0002579)3.47998641
51regulation of T cell mediated cytotoxicity (GO:0001914)3.47789402
52microglial cell activation (GO:0001774)3.47401618
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46798880
54respiratory burst (GO:0045730)3.46546721
55macrophage activation involved in immune response (GO:0002281)3.44838092
56positive regulation of interferon-alpha production (GO:0032727)3.44088809
57regulation of T cell tolerance induction (GO:0002664)3.43379754
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42032526
59regulation of mast cell degranulation (GO:0043304)3.41532354
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.40931674
61thymic T cell selection (GO:0045061)3.39993873
62detection of biotic stimulus (GO:0009595)3.39707684
63response to muramyl dipeptide (GO:0032495)3.36937227
64neutrophil mediated immunity (GO:0002446)3.36444851
65regulation of regulatory T cell differentiation (GO:0045589)3.36305884
66myeloid dendritic cell activation (GO:0001773)3.36225927
67antigen processing and presentation via MHC class Ib (GO:0002475)3.35113367
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33066205
69myeloid cell activation involved in immune response (GO:0002275)3.31474393
70regulation of interferon-alpha production (GO:0032647)3.27747341
71regulation of chemokine secretion (GO:0090196)3.27325924
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26367082
73positive T cell selection (GO:0043368)3.25274914
74neutrophil activation (GO:0042119)3.23937513
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23799280
76response to host (GO:0075136)3.23799280
77response to host defenses (GO:0052200)3.23799280
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23519934
79regulation of natural killer cell mediated immunity (GO:0002715)3.23406320
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.23406320
81antigen receptor-mediated signaling pathway (GO:0050851)3.21927537
82response to type I interferon (GO:0034340)3.20695421
83positive regulation of tolerance induction (GO:0002645)3.20474875
84type I interferon signaling pathway (GO:0060337)3.20047333
85cellular response to type I interferon (GO:0071357)3.20047333
86dendritic cell chemotaxis (GO:0002407)3.19480191
87G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.18978194
88response to peptidoglycan (GO:0032494)3.18672804
89regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18269200
90production of molecular mediator involved in inflammatory response (GO:0002532)3.17966501
91sequestering of actin monomers (GO:0042989)3.17467823
92interferon-gamma-mediated signaling pathway (GO:0060333)3.15849063
93T cell receptor signaling pathway (GO:0050852)3.15754101
94T cell selection (GO:0045058)3.15360666
95B cell mediated immunity (GO:0019724)3.13659133
96negative regulation of interleukin-12 production (GO:0032695)3.13633407
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13587183
98macrophage activation (GO:0042116)3.12656741
99regulation of mast cell activation involved in immune response (GO:0033006)3.12253048
100regulation of antigen processing and presentation (GO:0002577)3.11097849
101regulation of interleukin-12 biosynthetic process (GO:0045075)3.10165967
102dendritic cell migration (GO:0036336)3.09656488
103positive regulation of mast cell activation (GO:0033005)3.08407086
104positive regulation of granulocyte differentiation (GO:0030854)3.06867630
105negative regulation of innate immune response (GO:0045824)3.06426136
106regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05714477
107cellular response to interferon-beta (GO:0035458)3.05513115
108activated T cell proliferation (GO:0050798)3.03098453
109granulocyte activation (GO:0036230)3.03054305
110cellular defense response (GO:0006968)3.02909497
111myeloid dendritic cell differentiation (GO:0043011)3.02804961
112natural killer cell activation (GO:0030101)3.02098014
113regulation of response to interferon-gamma (GO:0060330)3.01933416
114regulation of leukocyte degranulation (GO:0043300)3.01044069
115regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00741929
116regulation of interleukin-2 biosynthetic process (GO:0045076)2.99742026
117NIK/NF-kappaB signaling (GO:0038061)2.99719632
118positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98627183
119myeloid leukocyte mediated immunity (GO:0002444)2.98178431
120regulation of T cell receptor signaling pathway (GO:0050856)2.97981051
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.97816228
122negative regulation of erythrocyte differentiation (GO:0045647)2.97278289
123regulation of mast cell activation (GO:0033003)2.96153470
124positive regulation of isotype switching (GO:0045830)2.95025349
125germinal center formation (GO:0002467)2.93967838
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93120420
127* leukocyte cell-cell adhesion (GO:0007159)2.91251634
128T cell costimulation (GO:0031295)2.89853776
129leukocyte degranulation (GO:0043299)2.89042312
130cellular response to zinc ion (GO:0071294)2.88523588
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87772053
132defense response to protozoan (GO:0042832)2.87255128
133mature B cell differentiation (GO:0002335)2.86918319
134JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.86532355
135mast cell activation involved in immune response (GO:0002279)2.85342248
136mast cell degranulation (GO:0043303)2.85342248
137regulation of alpha-beta T cell proliferation (GO:0046640)2.84788579
138lymphocyte costimulation (GO:0031294)2.84766024
139T cell homeostasis (GO:0043029)2.84600953
140response to protozoan (GO:0001562)2.83591440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78527070
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.71811153
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.58726457
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19882905
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.86169687
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70597454
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67264859
8E2F7_22180533_ChIP-Seq_HELA_Human3.51668872
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.21062845
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09062339
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08900985
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.97770738
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96749799
14SCL_19346495_ChIP-Seq_HPC-7_Human2.88127718
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.85773260
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78535552
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73748387
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71993824
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71608899
20VDR_21846776_ChIP-Seq_THP-1_Human2.70375206
21RUNX_20019798_ChIP-Seq_JUKART_Human2.70078152
22* MYC_22102868_ChIP-Seq_BL_Human2.66230315
23* MYB_26560356_Chip-Seq_TH2_Human2.64660443
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.58647632
25* SPI1_23547873_ChIP-Seq_NB4_Human2.55734131
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.51030139
27* MAF_26560356_Chip-Seq_TH1_Human2.47925266
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33413605
29* MYB_26560356_Chip-Seq_TH1_Human2.25294572
30VDR_24763502_ChIP-Seq_THP-1_Human2.21292233
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.20063392
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15557325
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11744351
34* UTX_26944678_Chip-Seq_JUKART_Human2.10724339
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94936084
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.90832935
37* SPI1_23127762_ChIP-Seq_K562_Human1.89518875
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89489977
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89046017
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.83979230
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83068513
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77134968
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74100479
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71275798
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69827029
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61571127
47* MAF_26560356_Chip-Seq_TH2_Human1.60168906
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.60144428
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53770484
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.53505662
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49723798
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48414364
53PU_27001747_Chip-Seq_BMDM_Mouse1.47303193
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44818529
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40841987
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37377612
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36825607
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34994149
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32718205
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29834420
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28069865
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27821050
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25775937
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24894107
65KDM2B_26808549_Chip-Seq_DND41_Human1.24826666
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22976004
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.17155551
68GATA1_19941826_ChIP-Seq_K562_Human1.16595300
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16248867
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15841388
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.14891946
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13876087
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13630273
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12083863
75* GATA3_26560356_Chip-Seq_TH2_Human1.11373854
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09695929
77BCOR_27268052_Chip-Seq_Bcells_Human1.09363546
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08646649
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.08189285
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08099351
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07491405
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07268034
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07041180
84CIITA_25753668_ChIP-Seq_RAJI_Human1.05778065
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05762404
86GATA1_22025678_ChIP-Seq_K562_Human1.03736708
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03266912
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02000311
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01788497
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95300255
91E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95075700
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94768352
93VDR_23849224_ChIP-Seq_CD4+_Human0.94706572
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93673149
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92754364
96VDR_24787735_ChIP-Seq_THP-1_Human0.92547599
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.92481701
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89759663
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.89751876
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89371531
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88741866
102NCOR1_26117541_ChIP-Seq_K562_Human0.88053092
103* GATA2_19941826_ChIP-Seq_K562_Human0.84096072
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83149654
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81298093
106LXR_22292898_ChIP-Seq_THP-1_Human0.80292548
107SPI1_20517297_ChIP-Seq_HL60_Human0.78305117
108FOXP3_21729870_ChIP-Seq_TREG_Human0.78291237
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78114010
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77806134
111* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76342620
112BCL6_27268052_Chip-Seq_Bcells_Human0.74723699
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73467387
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69604562
115SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68866376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.28714848
2MP0005671_abnormal_response_to3.99174953
3MP0000685_abnormal_immune_system3.23483017
4MP0006082_CNS_inflammation3.23454270
5MP0009785_altered_susceptibility_to3.09215343
6MP0003763_abnormal_thymus_physiology3.06746129
7MP0003436_decreased_susceptibility_to3.04912246
8MP0001800_abnormal_humoral_immune3.00127962
9MP0005000_abnormal_immune_tolerance2.95678856
10MP0002452_abnormal_antigen_presenting2.81535147
11MP0005025_abnormal_response_to2.79809444
12MP0001790_abnormal_immune_system2.76173873
13MP0005387_immune_system_phenotype2.76173873
14* MP0002723_abnormal_immune_serum2.75191453
15* MP0001819_abnormal_immune_cell2.72518863
16* MP0002420_abnormal_adaptive_immunity2.72203839
17* MP0002419_abnormal_innate_immunity2.71355566
18MP0002148_abnormal_hypersensitivity_rea2.65222560
19MP0002396_abnormal_hematopoietic_system2.55617041
20MP0005464_abnormal_platelet_physiology2.50476994
21MP0003724_increased_susceptibility_to2.45216580
22MP0002166_altered_tumor_susceptibility2.43989834
23* MP0002398_abnormal_bone_marrow2.41968182
24MP0009333_abnormal_splenocyte_physiolog2.39347516
25MP0003303_peritoneal_inflammation2.36856266
26* MP0000716_abnormal_immune_system2.25402761
27MP0002405_respiratory_system_inflammati2.24311450
28MP0002006_tumorigenesis2.11634384
29MP0000689_abnormal_spleen_morphology2.07909904
30MP0005058_abnormal_lysosome_morphology2.05696070
31MP0002722_abnormal_immune_system2.04530900
32MP0001873_stomach_inflammation1.96477381
33MP0003191_abnormal_cellular_cholesterol1.95805085
34MP0010155_abnormal_intestine_physiology1.93306704
35MP0003172_abnormal_lysosome_physiology1.90241783
36* MP0002429_abnormal_blood_cell1.87507769
37MP0001853_heart_inflammation1.87139290
38MP0001845_abnormal_inflammatory_respons1.82231560
39MP0003300_gastrointestinal_ulcer1.81771055
40MP0004510_myositis1.78827229
41MP0000703_abnormal_thymus_morphology1.77197519
42MP0004947_skin_inflammation1.76745286
43MP0009278_abnormal_bone_marrow1.68096702
44MP0005397_hematopoietic_system_phenotyp1.66428455
45MP0001545_abnormal_hematopoietic_system1.66428455
46MP0008260_abnormal_autophagy1.62996074
47MP0001533_abnormal_skeleton_physiology1.60927003
48MP0004808_abnormal_hematopoietic_stem1.55421892
49MP0000858_altered_metastatic_potential1.52702202
50MP0000465_gastrointestinal_hemorrhage1.51254897
51MP0008469_abnormal_protein_level1.51076565
52MP0002277_abnormal_respiratory_mucosa1.49077897
53MP0003866_abnormal_defecation1.49032552
54MP0002933_joint_inflammation1.43051727
55MP0005310_abnormal_salivary_gland1.39297938
56MP0000490_abnormal_crypts_of1.38677134
57MP0005174_abnormal_tail_pigmentation1.34384906
58MP0003448_altered_tumor_morphology1.29965175
59MP0000343_altered_response_to1.28219866
60MP0005075_abnormal_melanosome_morpholog1.26001383
61MP0001851_eye_inflammation1.23150707
62MP0003075_altered_response_to1.14669472
63MP0005451_abnormal_body_composition1.12678285
64MP0003183_abnormal_peptide_metabolism1.07591631
65MP0002998_abnormal_bone_remodeling1.06878733
66MP0003690_abnormal_glial_cell1.04626514
67MP0008007_abnormal_cellular_replicative1.01781552
68MP0009840_abnormal_foam_cell0.98522500
69MP0002019_abnormal_tumor_incidence0.93966931
70MP0005164_abnormal_response_to0.91462727
71MP0009764_decreased_sensitivity_to0.91293795
72MP0000015_abnormal_ear_pigmentation0.89043552
73MP0005166_decreased_susceptibility_to0.88204184
74MP0002132_abnormal_respiratory_system0.83944325
75MP0000604_amyloidosis0.83268540
76MP0001986_abnormal_taste_sensitivity0.79813891
77MP0009763_increased_sensitivity_to0.79219613
78MP0003806_abnormal_nucleotide_metabolis0.78897336
79MP0002138_abnormal_hepatobiliary_system0.74687570
80MP0008057_abnormal_DNA_replication0.72338679
81MP0010307_abnormal_tumor_latency0.71571023
82MP0003656_abnormal_erythrocyte_physiolo0.70792976
83MP0005023_abnormal_wound_healing0.70728285
84MP0003828_pulmonary_edema0.70501269
85MP0000249_abnormal_blood_vessel0.70275402
86MP0002095_abnormal_skin_pigmentation0.69830370
87MP0003045_fibrosis0.68854701
88MP0003077_abnormal_cell_cycle0.68348089
89MP0005390_skeleton_phenotype0.68029731
90MP0008058_abnormal_DNA_repair0.67507260
91MP0010094_abnormal_chromosome_stability0.66836177
92MP0008873_increased_physiological_sensi0.66521254
93MP0008004_abnormal_stomach_pH0.64964474
94MP0004130_abnormal_muscle_cell0.64490087
95MP0008874_decreased_physiological_sensi0.63426011
96MP0002928_abnormal_bile_duct0.62789959
97MP0004381_abnormal_hair_follicle0.59329186
98MP0002009_preneoplasia0.58804758
99MP0003453_abnormal_keratinocyte_physiol0.58250290
100MP0000371_diluted_coat_color0.58211907
101MP0003795_abnormal_bone_structure0.57726186
102MP0001663_abnormal_digestive_system0.56780317
103MP0003693_abnormal_embryo_hatching0.55742747
104MP0000313_abnormal_cell_death0.55728673
105MP0010352_gastrointestinal_tract_polyps0.55301170
106MP0002693_abnormal_pancreas_physiology0.52940815
107MP0005076_abnormal_cell_differentiation0.51046406
108MP0000477_abnormal_intestine_morphology0.48777410
109MP0002136_abnormal_kidney_physiology0.48488671
110MP0005319_abnormal_enzyme/_coenzyme0.48071596
111MP0003566_abnormal_cell_adhesion0.47936459
112MP0000920_abnormal_myelination0.47436095
113MP0001915_intracranial_hemorrhage0.46667449
114MP0009765_abnormal_xenobiotic_induced0.46548698
115MP0005083_abnormal_biliary_tract0.45753936
116MP0005381_digestive/alimentary_phenotyp0.44764737
117MP0004883_abnormal_blood_vessel0.44495172
118MP0003221_abnormal_cardiomyocyte_apopto0.42129022
119MP0000609_abnormal_liver_physiology0.41138389
120MP0005377_hearing/vestibular/ear_phenot0.40435897

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.67076356
2Eczematoid dermatitis (HP:0000976)5.31813857
3Elevated erythrocyte sedimentation rate (HP:0003565)5.26695129
4Systemic lupus erythematosus (HP:0002725)5.03900870
5Myositis (HP:0100614)4.94557360
6Recurrent bacterial skin infections (HP:0005406)4.92667887
7Recurrent fungal infections (HP:0002841)4.27716196
8IgM deficiency (HP:0002850)4.26929904
9Gastrointestinal infarctions (HP:0005244)4.17172430
10Chronic otitis media (HP:0000389)3.98741782
11Recurrent viral infections (HP:0004429)3.97974923
12T lymphocytopenia (HP:0005403)3.73935583
13Hypochromic microcytic anemia (HP:0004840)3.71737321
14Abnormality of T cell number (HP:0011839)3.68560735
15Recurrent skin infections (HP:0001581)3.65912020
16Glomerulonephritis (HP:0000099)3.64527949
17Chronic mucocutaneous candidiasis (HP:0002728)3.57180976
18Recurrent cutaneous fungal infections (HP:0011370)3.57180976
19Orchitis (HP:0100796)3.53454000
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.49870092
21Abnormality of T cells (HP:0002843)3.46399920
22Abnormality of glycolipid metabolism (HP:0010969)3.45437750
23Abnormality of liposaccharide metabolism (HP:0010968)3.45437750
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.45437750
25Recurrent gram-negative bacterial infections (HP:0005420)3.43247666
26Urticaria (HP:0001025)3.42945880
27Abnormality of macrophages (HP:0004311)3.41359778
28Mediastinal lymphadenopathy (HP:0100721)3.39065133
29Meningitis (HP:0001287)3.38495024
30Retrobulbar optic neuritis (HP:0100654)3.36700509
31Optic neuritis (HP:0100653)3.36700509
32Hypochromic anemia (HP:0001931)3.36675006
33Nasal polyposis (HP:0100582)3.36417440
34Chronic obstructive pulmonary disease (HP:0006510)3.32231504
35Obstructive lung disease (HP:0006536)3.32231504
36Stomatitis (HP:0010280)3.30719309
37Pustule (HP:0200039)3.26306502
38Spontaneous hematomas (HP:0007420)3.24876108
39Chest pain (HP:0100749)3.23486771
40Recurrent bronchitis (HP:0002837)3.21708353
41Inflammation of the large intestine (HP:0002037)3.17485175
42Panhypogammaglobulinemia (HP:0003139)3.15634937
43Chronic diarrhea (HP:0002028)3.15632007
44Abnormality of the nasal mucosa (HP:0000433)3.10095289
45Abnormality of T cell physiology (HP:0011840)3.06869585
46Gastrointestinal inflammation (HP:0004386)3.05995669
47Eosinophilia (HP:0001880)2.96307758
48Leukocytosis (HP:0001974)2.95908432
49Vasculitis (HP:0002633)2.94418647
50Petechiae (HP:0000967)2.92855912
51Episodic fever (HP:0001954)2.91063468
52Thrombocytosis (HP:0001894)2.85517899
53Colitis (HP:0002583)2.85169180
54Vacuolated lymphocytes (HP:0001922)2.84274142
55Increased cerebral lipofuscin (HP:0011813)2.83204513
56Abnormality of eosinophils (HP:0001879)2.82955916
57Severe combined immunodeficiency (HP:0004430)2.82277478
58Dysostosis multiplex (HP:0000943)2.79666757
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.78227589
60IgG deficiency (HP:0004315)2.75364242
61Granulocytopenia (HP:0001913)2.74717972
62Cellulitis (HP:0100658)2.73098073
63Thyroiditis (HP:0100646)2.72529794
64Lymphopenia (HP:0001888)2.69937065
65Prolonged bleeding time (HP:0003010)2.66532608
66Anorexia (HP:0002039)2.66340092
67Pulmonary embolism (HP:0002204)2.65009766
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.64048899
69Gingivitis (HP:0000230)2.61051267
70Combined immunodeficiency (HP:0005387)2.60011118
71Increased IgM level (HP:0003496)2.59533843
72Hematochezia (HP:0002573)2.59215860
73Microcytic anemia (HP:0001935)2.57342193
74Hypergammaglobulinemia (HP:0010702)2.55289437
75Autoimmune thrombocytopenia (HP:0001973)2.53763949
76Encephalitis (HP:0002383)2.53533035
77Hemoptysis (HP:0002105)2.52506608
78Increased IgE level (HP:0003212)2.51703041
79Epistaxis (HP:0000421)2.51289710
80Agnosia (HP:0010524)2.50261450
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45962897
82Sepsis (HP:0100806)2.43181050
83Osteomyelitis (HP:0002754)2.42412419
84Interstitial pulmonary disease (HP:0006530)2.42010007
85Pulmonary infiltrates (HP:0002113)2.41752145
86Arterial thrombosis (HP:0004420)2.39035722
87Agammaglobulinemia (HP:0004432)2.35560030
88Peritonitis (HP:0002586)2.35421081
89Abnormality of the pleura (HP:0002103)2.35378030
90Keratoconjunctivitis sicca (HP:0001097)2.35323927
91Hepatosplenomegaly (HP:0001433)2.33794931
92Basal ganglia calcification (HP:0002135)2.33518170
93Purpura (HP:0000979)2.27987363
94Gangrene (HP:0100758)2.27509063
95B lymphocytopenia (HP:0010976)2.24961259
96Abnormality of B cell number (HP:0010975)2.24961259
97Autoimmune hemolytic anemia (HP:0001890)2.24495320
98Periodontitis (HP:0000704)2.24044125
99Amyloidosis (HP:0011034)2.22847684
100Abnormality of the fingertips (HP:0001211)2.20839014
101Abnormal platelet function (HP:0011869)2.20145048
102Impaired platelet aggregation (HP:0003540)2.20145048
103Lymphoma (HP:0002665)2.17435155
104Complement deficiency (HP:0004431)2.14708092
105Mucopolysacchariduria (HP:0008155)2.14669608
106Urinary glycosaminoglycan excretion (HP:0003541)2.14669608
107Acute hepatic failure (HP:0006554)2.14329592
108Cheilitis (HP:0100825)2.14231494
109Glomerulopathy (HP:0100820)2.12272464
110Keratoconjunctivitis (HP:0001096)2.11801071
111Increased serum ferritin (HP:0003281)2.09151508
112Slow saccadic eye movements (HP:0000514)2.08537736
113IgA deficiency (HP:0002720)2.08131649
114Spondylolisthesis (HP:0003302)2.05687717
115Abnormality of the prostate (HP:0008775)2.04758374
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03301114
117Abnormality of the peritoneum (HP:0002585)2.02501171
118Gingival bleeding (HP:0000225)2.02197210
119Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01278575
120Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01278575
121Abnormality of polysaccharide metabolism (HP:0011012)2.01278575
122Skin ulcer (HP:0200042)1.99795958
123Joint swelling (HP:0001386)1.99640401
124Abnormality of iron homeostasis (HP:0011031)1.99523919
125Premature loss of primary teeth (HP:0006323)1.96881226
126Abnormality of the pericardium (HP:0001697)1.96256656
127Keratitis (HP:0000491)1.93828210
128Skin rash (HP:0000988)1.93200999
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.92768918
130Acne (HP:0001061)1.92041225
131Vertigo (HP:0002321)1.90806728
132Loss of speech (HP:0002371)1.90711234
133Verrucae (HP:0200043)1.88608207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.66077334
2TXK3.80661918
3TGFBR23.63495396
4TYK23.09956189
5BLK2.89179391
6IRAK42.83372649
7CSF1R2.69719346
8ZAP702.68571997
9TBK12.42379397
10JAK32.35716513
11KIT2.25081355
12IKBKE2.18807914
13PRPF4B2.18384576
14STK102.15353801
15IRAK32.11836110
16MAP3K142.06116956
17ITK2.05320021
18BTK1.95221799
19CLK11.93695345
20TEC1.91351545
21JAK11.89906330
22CSK1.62769931
23SYK1.62176085
24LCK1.59932888
25TAOK11.58852379
26MAP3K31.58167132
27HCK1.54461621
28RIPK41.52868556
29EEF2K1.49933952
30IKBKB1.49036238
31GRK61.44581522
32FES1.42199672
33GRK71.41110482
34FGFR41.40710353
35MAP2K31.30583494
36EPHB11.29740733
37FLT31.27922711
38TSSK61.25475695
39MAPK151.24588849
40ERN11.23741220
41TESK21.16052600
42LYN1.14168094
43MAP3K131.13552455
44MAP3K11.08901050
45PAK41.06195603
46MAP3K101.03116677
47FGFR31.02125397
48PIM11.00556764
49NLK0.97278103
50KDR0.96102038
51RPS6KA40.93092963
52JAK20.91823314
53TAOK30.91439467
54KSR20.90401909
55TAOK20.87938241
56NME20.86395839
57MARK30.84761814
58ADRBK20.82236211
59PKN20.81885397
60MARK20.80790954
61VRK10.79687072
62LRRK20.77696877
63PRKD20.77580291
64CDK190.76408639
65PIM20.75996847
66FYN0.73280358
67CHUK0.72328048
68CAMKK10.71556836
69MAP3K120.70440194
70SIK20.68384996
71TNK20.67731117
72BMPR20.65006093
73PDPK10.64008655
74MAP3K70.62203743
75SMG10.61706439
76MATK0.61283773
77IRAK10.57263048
78CDK40.53244571
79MAPKAPK20.52640924
80STK40.52167658
81RPS6KA60.51770044
82TRPM70.51339073
83NEK90.50282680
84MAP3K110.50139186
85DYRK1B0.50073735
86PIK3CG0.49585687
87MAP3K60.48766954
88STK110.48232872
89MAPK120.48224688
90STK380.47671868
91MAP3K50.47202953
92PTK2B0.46970514
93CDC42BPA0.46156290
94SIK30.45899992
95CAMK1D0.44337131
96SCYL20.43308317
97MAPK40.43283203
98PDK10.42477101
99PRKCQ0.39881287
100PASK0.38447240
101CAMKK20.38273145
102MAPK110.37825025
103RPS6KL10.36963027
104RPS6KC10.36963027
105RAF10.36249963
106CDK60.34396194
107TGFBR10.34392555
108TRIB30.34050024
109MAPKAPK30.32650935
110PRKCD0.32305609
111RET0.32112450
112SGK30.31874494
113MAP2K20.31375205
114MAPK70.30292135
115PRKCH0.30102214
116MST40.30082382
117MAP3K80.30071377
118SIK10.29964349
119IRAK20.29566054
120IGF1R0.29191740
121FGR0.28684801
122HIPK20.28318396
123PTK60.27996295
124EPHA30.27685867
125MAP2K40.27476955
126YES10.27370343
127ABL10.27265130
128RPS6KB20.23778845
129EIF2AK20.23053929
130MAP2K60.22881000

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33209030
2Leishmaniasis_Homo sapiens_hsa051402.81443628
3Antigen processing and presentation_Homo sapiens_hsa046122.62393236
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61468584
5Other glycan degradation_Homo sapiens_hsa005112.51672151
6Osteoclast differentiation_Homo sapiens_hsa043802.46648979
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.45600549
8Measles_Homo sapiens_hsa051622.45582202
9Graft-versus-host disease_Homo sapiens_hsa053322.32068550
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.27119642
11* Staphylococcus aureus infection_Homo sapiens_hsa051502.26269249
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.23306981
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.15087822
14Hematopoietic cell lineage_Homo sapiens_hsa046402.12322449
15B cell receptor signaling pathway_Homo sapiens_hsa046622.07187707
16T cell receptor signaling pathway_Homo sapiens_hsa046602.01137123
17Allograft rejection_Homo sapiens_hsa053301.97669545
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89112080
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83125693
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82119531
21Pertussis_Homo sapiens_hsa051331.81804265
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75931083
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69913576
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62725969
25Legionellosis_Homo sapiens_hsa051341.59996557
26Toxoplasmosis_Homo sapiens_hsa051451.59229709
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.58181465
28Herpes simplex infection_Homo sapiens_hsa051681.57736964
29Tuberculosis_Homo sapiens_hsa051521.46430826
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45841079
31Chemokine signaling pathway_Homo sapiens_hsa040621.43730255
32Influenza A_Homo sapiens_hsa051641.40631417
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38246473
34Shigellosis_Homo sapiens_hsa051311.36099997
35DNA replication_Homo sapiens_hsa030301.35696318
36Lysosome_Homo sapiens_hsa041421.34882462
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26586302
38Hepatitis B_Homo sapiens_hsa051611.26311618
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.24667799
40Viral myocarditis_Homo sapiens_hsa054161.24409792
41Malaria_Homo sapiens_hsa051441.24052468
42Acute myeloid leukemia_Homo sapiens_hsa052211.22333748
43Apoptosis_Homo sapiens_hsa042101.20639950
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15317399
45TNF signaling pathway_Homo sapiens_hsa046681.11822934
46Autoimmune thyroid disease_Homo sapiens_hsa053201.10156633
47Asthma_Homo sapiens_hsa053101.09490541
48Salmonella infection_Homo sapiens_hsa051321.05755944
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01822059
50Pancreatic cancer_Homo sapiens_hsa052120.99729417
51Platelet activation_Homo sapiens_hsa046110.99344463
52Ribosome_Homo sapiens_hsa030100.97147572
53Epstein-Barr virus infection_Homo sapiens_hsa051690.97046293
54Chronic myeloid leukemia_Homo sapiens_hsa052200.95203107
55Base excision repair_Homo sapiens_hsa034100.88970000
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87401065
57Mismatch repair_Homo sapiens_hsa034300.85460987
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78349276
59HTLV-I infection_Homo sapiens_hsa051660.77993860
60Type I diabetes mellitus_Homo sapiens_hsa049400.77645652
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77019572
62Rheumatoid arthritis_Homo sapiens_hsa053230.76371024
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76092351
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74631072
65Colorectal cancer_Homo sapiens_hsa052100.74144944
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69708421
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.69360581
68Hepatitis C_Homo sapiens_hsa051600.68990532
69Non-homologous end-joining_Homo sapiens_hsa034500.67748955
70Viral carcinogenesis_Homo sapiens_hsa052030.64000569
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62946419
72Homologous recombination_Homo sapiens_hsa034400.61914293
73Spliceosome_Homo sapiens_hsa030400.59586888
74Notch signaling pathway_Homo sapiens_hsa043300.58778153
75Renal cell carcinoma_Homo sapiens_hsa052110.58486823
76Endocytosis_Homo sapiens_hsa041440.56801139
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55885397
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.54581567
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54488549
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.54195974
81Phagosome_Homo sapiens_hsa041450.52877614
82Prion diseases_Homo sapiens_hsa050200.52857559
83p53 signaling pathway_Homo sapiens_hsa041150.51671322
84VEGF signaling pathway_Homo sapiens_hsa043700.51659544
85African trypanosomiasis_Homo sapiens_hsa051430.51449863
86Regulation of autophagy_Homo sapiens_hsa041400.50218899
87Prolactin signaling pathway_Homo sapiens_hsa049170.50214219
88Choline metabolism in cancer_Homo sapiens_hsa052310.47512588
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46450312
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45965090
91Endometrial cancer_Homo sapiens_hsa052130.45815185
92Non-small cell lung cancer_Homo sapiens_hsa052230.44688533
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44375637
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.42372165
95Inositol phosphate metabolism_Homo sapiens_hsa005620.41075804
96GnRH signaling pathway_Homo sapiens_hsa049120.39547345
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.38926984
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38310124
99Amoebiasis_Homo sapiens_hsa051460.38275635
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38137814
101Small cell lung cancer_Homo sapiens_hsa052220.37397731
102Insulin resistance_Homo sapiens_hsa049310.36016482
103mTOR signaling pathway_Homo sapiens_hsa041500.33142424
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32328234
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31796704
106Fanconi anemia pathway_Homo sapiens_hsa034600.30207979
107Systemic lupus erythematosus_Homo sapiens_hsa053220.29353031
108Dorso-ventral axis formation_Homo sapiens_hsa043200.29243657
109MAPK signaling pathway_Homo sapiens_hsa040100.28342364
110FoxO signaling pathway_Homo sapiens_hsa040680.28070170
111Nucleotide excision repair_Homo sapiens_hsa034200.28003409
112N-Glycan biosynthesis_Homo sapiens_hsa005100.27515096
113HIF-1 signaling pathway_Homo sapiens_hsa040660.27282199
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27073144
115Type II diabetes mellitus_Homo sapiens_hsa049300.26072984
116* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25195790
117RNA degradation_Homo sapiens_hsa030180.25156304
118Pyrimidine metabolism_Homo sapiens_hsa002400.24977671
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21998344
120Pathways in cancer_Homo sapiens_hsa052000.20939838
121Proteasome_Homo sapiens_hsa030500.20819635
122Rap1 signaling pathway_Homo sapiens_hsa040150.20611575
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20212669
124Cell cycle_Homo sapiens_hsa041100.19433502

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »