SEL1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)4.55460606
2intestinal cholesterol absorption (GO:0030299)4.43969539
3cell adhesion mediated by integrin (GO:0033627)4.10808145
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90383185
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82765600
6L-phenylalanine catabolic process (GO:0006559)3.82765600
7iron ion import (GO:0097286)3.80605011
8protein retention in ER lumen (GO:0006621)3.62051901
9skin morphogenesis (GO:0043589)3.59772323
10L-phenylalanine metabolic process (GO:0006558)3.45848657
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.45848657
12Golgi transport vesicle coating (GO:0048200)3.45472897
13COPI coating of Golgi vesicle (GO:0048205)3.45472897
14gonadal mesoderm development (GO:0007506)3.34237688
15negative regulation of protein activation cascade (GO:2000258)3.13007238
16negative regulation of complement activation (GO:0045916)3.10044549
17cysteine metabolic process (GO:0006534)3.09211236
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.98024305
19regulation of transforming growth factor beta1 production (GO:0032908)2.97172697
20activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.96740807
21alpha-linolenic acid metabolic process (GO:0036109)2.95979222
22cellular modified amino acid catabolic process (GO:0042219)2.88859235
23negative regulation of fatty acid transport (GO:2000192)2.82569991
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.81404482
25transcytosis (GO:0045056)2.79058195
26L-serine transport (GO:0015825)2.77126328
27desmosome organization (GO:0002934)2.75250501
28chondrocyte development (GO:0002063)2.74866143
29aromatic amino acid family catabolic process (GO:0009074)2.74165014
30sequestering of extracellular ligand from receptor (GO:0035581)2.73286138
31positive regulation of nuclease activity (GO:0032075)2.72677037
32sulfur amino acid catabolic process (GO:0000098)2.71180134
33ER overload response (GO:0006983)2.70126498
34endoplasmic reticulum unfolded protein response (GO:0030968)2.69745317
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.68594811
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67524951
37COPII vesicle coating (GO:0048208)2.67383697
38positive regulation of cardiac muscle hypertrophy (GO:0010613)2.64584225
39positive regulation of muscle hypertrophy (GO:0014742)2.64584225
40peptidyl-glutamic acid carboxylation (GO:0017187)2.62001583
41protein carboxylation (GO:0018214)2.62001583
42digestion (GO:0007586)2.61090507
43hypotonic response (GO:0006971)2.58405883
44cellular response to unfolded protein (GO:0034620)2.58221777
45negative regulation of protein localization to plasma membrane (GO:1903077)2.58091550
46ER-nucleus signaling pathway (GO:0006984)2.57999820
47bile acid biosynthetic process (GO:0006699)2.56045275
48coenzyme catabolic process (GO:0009109)2.54249992
49oligosaccharide catabolic process (GO:0009313)2.53497655
50apoptotic cell clearance (GO:0043277)2.52709547
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.52558405
52serine transport (GO:0032329)2.50228023
53homocysteine metabolic process (GO:0050667)2.48331510
54membrane protein ectodomain proteolysis (GO:0006509)2.48331341
55intestinal absorption (GO:0050892)2.48227915
56glutamate metabolic process (GO:0006536)2.47474715
57reverse cholesterol transport (GO:0043691)2.45058814
58high-density lipoprotein particle remodeling (GO:0034375)2.44286969
59* response to endoplasmic reticulum stress (GO:0034976)2.44198574
60UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42491769
61glycolipid catabolic process (GO:0019377)2.42402088
62complement activation, classical pathway (GO:0006958)2.42292415
63macroautophagy (GO:0016236)2.42122255
644-hydroxyproline metabolic process (GO:0019471)2.41469574
65keratan sulfate catabolic process (GO:0042340)2.41199073
66cellular response to ethanol (GO:0071361)2.41063079
67protein targeting to Golgi (GO:0000042)2.40391110
68regulation of nuclease activity (GO:0032069)2.39543120
69cellular response to topologically incorrect protein (GO:0035967)2.38425295
70negative regulation of humoral immune response (GO:0002921)2.38421162
71positive regulation of extracellular matrix organization (GO:1903055)2.37680088
72negative regulation of digestive system process (GO:0060457)2.35912974
73wound healing, spreading of epidermal cells (GO:0035313)2.35527655
74positive regulation of receptor recycling (GO:0001921)2.35516817
75nerve growth factor signaling pathway (GO:0038180)2.35015816
76very-low-density lipoprotein particle assembly (GO:0034379)2.34549433
77glycosphingolipid catabolic process (GO:0046479)2.34394522
78cholesterol catabolic process (GO:0006707)2.32998665
79sterol catabolic process (GO:0016127)2.32998665
80short-chain fatty acid metabolic process (GO:0046459)2.32807670
81negative regulation of fibrinolysis (GO:0051918)2.32470454
82valine metabolic process (GO:0006573)2.32079976
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31698719
84positive regulation of coagulation (GO:0050820)2.29994971
85regulation of phospholipase A2 activity (GO:0032429)2.28502160
86aspartate family amino acid catabolic process (GO:0009068)2.27909854
87bile acid metabolic process (GO:0008206)2.25767578
88plasma lipoprotein particle clearance (GO:0034381)2.25678581
89surfactant homeostasis (GO:0043129)2.24443236
90establishment of protein localization to Golgi (GO:0072600)2.24426460
91complement activation, alternative pathway (GO:0006957)2.24270993
92lysine metabolic process (GO:0006553)2.23949484
93lysine catabolic process (GO:0006554)2.23949484
94interleukin-6-mediated signaling pathway (GO:0070102)2.23296205
95positive regulation of hemostasis (GO:1900048)2.22676949
96positive regulation of blood coagulation (GO:0030194)2.22676949
97Golgi organization (GO:0007030)2.21839068
98glyoxylate metabolic process (GO:0046487)2.21724517
99locomotory exploration behavior (GO:0035641)2.21443084
100regulation of transforming growth factor beta2 production (GO:0032909)2.21156936
101endoplasmic reticulum organization (GO:0007029)2.20766435
102membrane raft organization (GO:0031579)2.20753362
103collagen fibril organization (GO:0030199)2.20530958
104hemidesmosome assembly (GO:0031581)2.20350425
105import into cell (GO:0098657)2.19804547
106vesicle coating (GO:0006901)2.19729735
107negative regulation of anoikis (GO:2000811)2.19237481
108dicarboxylic acid biosynthetic process (GO:0043650)2.18996847
109retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18458557
110cholesterol transport (GO:0030301)2.17992701
111sterol transport (GO:0015918)2.17992701
112complement activation (GO:0006956)2.17980556
113ceramide catabolic process (GO:0046514)2.17085960
114positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.16213853
115urea metabolic process (GO:0019627)2.16053851
116urea cycle (GO:0000050)2.16053851
117cholesterol efflux (GO:0033344)2.15964621
118protein hydroxylation (GO:0018126)2.15847947
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.14387262
120regulation of fibrinolysis (GO:0051917)2.14053433
121lipid translocation (GO:0034204)2.13753810
122phospholipid translocation (GO:0045332)2.13753810
123peptidyl-proline hydroxylation (GO:0019511)2.13154992
124regulation of cholesterol homeostasis (GO:2000188)2.12968395
125sphingomyelin metabolic process (GO:0006684)2.12748168
126mannose metabolic process (GO:0006013)2.12684362
127regulation of protein activation cascade (GO:2000257)2.11867826
128endodermal cell differentiation (GO:0035987)2.11198648
129protein activation cascade (GO:0072376)2.11116973
130alanine transport (GO:0032328)2.09794919
131mRNA modification (GO:0016556)2.09018245
132tyrosine metabolic process (GO:0006570)2.08822911
133cellular glucuronidation (GO:0052695)2.08634671
134retrograde transport, vesicle recycling within Golgi (GO:0000301)2.08565043
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.08334646
136phospholipid homeostasis (GO:0055091)2.07719975
137protein-lipid complex remodeling (GO:0034368)2.07639986
138macromolecular complex remodeling (GO:0034367)2.07639986
139plasma lipoprotein particle remodeling (GO:0034369)2.07639986
140platelet-derived growth factor receptor signaling pathway (GO:0048008)2.07613769
141cellular potassium ion homeostasis (GO:0030007)2.07129471
142protein localization to endosome (GO:0036010)2.06697109
143detection of molecule of bacterial origin (GO:0032490)2.05967730
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.05423322
145cellular ketone body metabolic process (GO:0046950)2.04658323
146signal peptide processing (GO:0006465)2.04557224
147regulation of plasminogen activation (GO:0010755)2.03836351
148negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.03228868
149cellular amino acid catabolic process (GO:0009063)2.02814377
150membrane lipid catabolic process (GO:0046466)2.02110903
151fibrinolysis (GO:0042730)2.02015599
152kynurenine metabolic process (GO:0070189)2.01646061
153epoxygenase P450 pathway (GO:0019373)2.01061301
154glycine transport (GO:0015816)2.01031169
155regulation of ARF protein signal transduction (GO:0032012)2.00792901
156creatine metabolic process (GO:0006600)2.00731752
157negative regulation of lipid transport (GO:0032369)2.00583872
158hormone catabolic process (GO:0042447)2.00277894
159sphingosine metabolic process (GO:0006670)2.00017106
160regulation of complement activation (GO:0030449)1.99884195
161positive regulation of fatty acid beta-oxidation (GO:0032000)1.99527702
162response to unfolded protein (GO:0006986)1.99135066
163regulation of beta-amyloid formation (GO:1902003)1.98965207
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)1.98879707
165dicarboxylic acid catabolic process (GO:0043649)1.98877041
166negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.98802642
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.97936796
168response to methylmercury (GO:0051597)1.97147508
169positive regulation of lipid catabolic process (GO:0050996)1.96918861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.86316020
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.51585105
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25265357
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.85598738
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.64978701
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50284566
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31194121
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29098128
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.09081204
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99842805
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98339060
12WT1_19549856_ChIP-ChIP_CCG9911_Human1.96572800
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90528037
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81452529
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78992149
16SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77644567
17CJUN_26792858_Chip-Seq_BT549_Human1.74623372
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74499909
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69106844
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68946296
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66701948
22DROSHA_22980978_ChIP-Seq_HELA_Human1.66475480
23EZH2_22144423_ChIP-Seq_EOC_Human1.66466502
24GBX2_23144817_ChIP-Seq_PC3_Human1.65012985
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64272612
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63865775
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63491920
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61502896
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60619052
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55906011
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55000837
32BRD4_25478319_ChIP-Seq_HGPS_Human1.54861894
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53767998
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52580585
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52533208
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51475946
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51475946
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51458455
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49157575
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49156515
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.48356964
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48172767
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48172767
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46878116
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45670786
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45670786
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43202649
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41276091
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.41119329
50CLOCK_20551151_ChIP-Seq_293T_Human1.41036641
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.40090424
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38745563
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37477590
54AR_21572438_ChIP-Seq_LNCaP_Human1.36908825
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36386720
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35820187
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35656158
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35375937
59* TP63_23658742_ChIP-Seq_EP156T_Human1.34782924
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33653230
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33038094
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29992709
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.29353540
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27543823
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26976657
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.25512521
67* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25497379
68* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21890843
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20741689
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.18468347
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18020152
72VDR_24787735_ChIP-Seq_THP-1_Human1.17704902
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17203828
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16904669
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15203683
76AHR_22903824_ChIP-Seq_MCF-7_Human1.15003197
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14562598
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.14038576
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13843263
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.13077784
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12594938
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11874579
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10656201
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.10487694
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.09544675
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09387911
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.08832037
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08128458
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08006216
90GATA1_22025678_ChIP-Seq_K562_Human1.07703491
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.06855301
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06591569
93TAF15_26573619_Chip-Seq_HEK293_Human1.06278376
94* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05922247
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05225076
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.04493851
97* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04251264
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.03840395
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.03840395
100RXR_22108803_ChIP-Seq_LS180_Human1.03741322
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02564132
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02258651
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.01852602
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01213648
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00591764
106SOX2_21211035_ChIP-Seq_LN229_Gbm0.99009888
107* CDX2_22108803_ChIP-Seq_LS180_Human0.98336624
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98136968
109SMAD4_21799915_ChIP-Seq_A2780_Human0.97826262
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96961502
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.96495031
112SOX2_20726797_ChIP-Seq_SW620_Human0.95837084
113TP53_18474530_ChIP-ChIP_U2OS_Human0.95388142
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94813192
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.94212119
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94159114
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93966754
118* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93922460
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.93804775
120* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93800599
121* REST_21632747_ChIP-Seq_MESCs_Mouse0.93464709
122EZH2_27304074_Chip-Seq_ESCs_Mouse0.93227189
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.93179972
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93102919
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92689724
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92612073
127GATA4_25053715_ChIP-Seq_YYC3_Human0.92564313
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92532119
129KDM2B_26808549_Chip-Seq_K562_Human0.91825545
130AR_19668381_ChIP-Seq_PC3_Human0.90221395
131TP53_16413492_ChIP-PET_HCT116_Human0.89890173
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88845866
133* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88436471
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87697425
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86935191
136BCAT_22108803_ChIP-Seq_LS180_Human0.86455362
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86101136
138AR_25329375_ChIP-Seq_VCAP_Human0.84836376
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84016160
140STAT3_23295773_ChIP-Seq_U87_Human0.83468076
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83419112
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.83265824
143TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82921331
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82412523
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82348238
146* ZNF274_21170338_ChIP-Seq_K562_Hela0.82024448
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81586620
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80839229
149GATA1_19941826_ChIP-Seq_K562_Human0.80302276
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.79436731
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79382545
152* FOXA1_25552417_ChIP-Seq_VCAP_Human0.78295197
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.77054940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt4.29370480
2MP0005083_abnormal_biliary_tract4.05316274
3MP0002139_abnormal_hepatobiliary_system4.04661652
4MP0001666_abnormal_nutrient_absorption3.93595869
5MP0005085_abnormal_gallbladder_physiolo3.37808247
6MP0005360_urolithiasis3.22101042
7MP0005275_abnormal_skin_tensile3.06957502
8MP0003868_abnormal_feces_composition2.51054826
9MP0006054_spinal_hemorrhage2.48674821
10MP0003566_abnormal_cell_adhesion2.41146418
11MP0005220_abnormal_exocrine_pancreas2.39757040
12MP0010352_gastrointestinal_tract_polyps2.38977673
13MP0003252_abnormal_bile_duct2.36278093
14MP0001958_emphysema2.33716629
15MP0009780_abnormal_chondrocyte_physiolo2.32494877
16MP0004859_abnormal_synaptic_plasticity2.27226719
17MP0005058_abnormal_lysosome_morphology2.16568582
18MP0008875_abnormal_xenobiotic_pharmacok2.14076448
19MP0010329_abnormal_lipoprotein_level2.10653424
20MP0000569_abnormal_digit_pigmentation2.04686168
21MP0003950_abnormal_plasma_membrane2.04658159
22MP0003329_amyloid_beta_deposits1.94263291
23MP0003091_abnormal_cell_migration1.92301335
24MP0003195_calcinosis1.90358083
25MP0002877_abnormal_melanocyte_morpholog1.87476123
26MP0002166_altered_tumor_susceptibility1.80503908
27MP0010234_abnormal_vibrissa_follicle1.79814012
28MP0003690_abnormal_glial_cell1.78482096
29MP0008438_abnormal_cutaneous_collagen1.78023109
30MP0003279_aneurysm1.77486355
31MP0000604_amyloidosis1.72779438
32MP0002118_abnormal_lipid_homeostasis1.71479461
33MP0003300_gastrointestinal_ulcer1.60913734
34MP0004270_analgesia1.58595050
35MP0010368_abnormal_lymphatic_system1.56327360
36MP0005332_abnormal_amino_acid1.55639214
37MP0005164_abnormal_response_to1.51070277
38MP0005084_abnormal_gallbladder_morpholo1.50618325
39MP0000920_abnormal_myelination1.48712215
40MP0002909_abnormal_adrenal_gland1.45518138
41MP0009840_abnormal_foam_cell1.44213844
42MP0003172_abnormal_lysosome_physiology1.43421556
43MP0003635_abnormal_synaptic_transmissio1.43129207
44MP0003705_abnormal_hypodermis_morpholog1.42516437
45MP0005257_abnormal_intraocular_pressure1.40015187
46MP0002138_abnormal_hepatobiliary_system1.39531836
47MP0005409_darkened_coat_color1.38898812
48MP0002060_abnormal_skin_morphology1.38725594
49MP0010678_abnormal_skin_adnexa1.37402574
50MP0003183_abnormal_peptide_metabolism1.36268295
51MP0009384_cardiac_valve_regurgitation1.33903072
52MP0002693_abnormal_pancreas_physiology1.31854897
53MP0000013_abnormal_adipose_tissue1.31264195
54MP0005503_abnormal_tendon_morphology1.26097561
55MP0005451_abnormal_body_composition1.24662474
56MP0003656_abnormal_erythrocyte_physiolo1.24561081
57MP0004043_abnormal_pH_regulation1.24296156
58MP0002006_tumorigenesis1.22928632
59MP0005535_abnormal_body_temperature1.22813583
60MP0003191_abnormal_cellular_cholesterol1.22800855
61MP0002090_abnormal_vision1.21955116
62MP0004264_abnormal_extraembryonic_tissu1.20947870
63MP0002009_preneoplasia1.19584334
64MP0002295_abnormal_pulmonary_circulatio1.17728646
65MP0002168_other_aberrant_phenotype1.17112857
66MP0005023_abnormal_wound_healing1.16638891
67MP0002064_seizures1.16265016
68MP0005408_hypopigmentation1.16231845
69MP0000767_abnormal_smooth_muscle1.15439612
70MP0000003_abnormal_adipose_tissue1.15157954
71MP0008004_abnormal_stomach_pH1.15154637
72MP0003941_abnormal_skin_development1.14583117
73MP0004883_abnormal_blood_vessel1.13908078
74MP0003828_pulmonary_edema1.12001881
75MP0004130_abnormal_muscle_cell1.11771231
76* MP0001944_abnormal_pancreas_morphology1.10718555
77MP0003880_abnormal_central_pattern1.09311987
78MP0002078_abnormal_glucose_homeostasis1.09210567
79MP0009745_abnormal_behavioral_response1.05031739
80MP0002998_abnormal_bone_remodeling1.03960683
81MP0003959_abnormal_lean_body1.03599876
82MP0003075_altered_response_to1.03223491
83MP0002876_abnormal_thyroid_physiology1.02480040
84MP0003633_abnormal_nervous_system1.01953578
85MP0002063_abnormal_learning/memory/cond1.01652598
86* MP0000609_abnormal_liver_physiology1.00741351
87MP0003453_abnormal_keratinocyte_physiol1.00729249
88MP0005584_abnormal_enzyme/coenzyme_acti1.00150763
89MP0004782_abnormal_surfactant_physiolog0.98253772
90MP0005448_abnormal_energy_balance0.94817352
91MP0001664_abnormal_digestion0.94653036
92MP0009643_abnormal_urine_homeostasis0.94430678
93MP0000371_diluted_coat_color0.93658659
94MP0003045_fibrosis0.93305602
95MP0003634_abnormal_glial_cell0.91828983
96MP0000427_abnormal_hair_cycle0.91320905
97MP0005623_abnormal_meninges_morphology0.90813952
98MP0003724_increased_susceptibility_to0.90452971
99MP0005076_abnormal_cell_differentiation0.90440684
100MP0005310_abnormal_salivary_gland0.88595138
101MP0001915_intracranial_hemorrhage0.86501552
102MP0004858_abnormal_nervous_system0.86018064
103MP0002272_abnormal_nervous_system0.85706840
104MP0001765_abnormal_ion_homeostasis0.85613984
105MP0005165_increased_susceptibility_to0.85243885
106MP0000685_abnormal_immune_system0.85058850
107MP0010386_abnormal_urinary_bladder0.83326915
108MP0002896_abnormal_bone_mineralization0.83187953
109MP0001501_abnormal_sleep_pattern0.81774849
110MP0004947_skin_inflammation0.80384073
111MP0002229_neurodegeneration0.80164996
112MP0001486_abnormal_startle_reflex0.80133751
113MP0005388_respiratory_system_phenotype0.80012507
114MP0002133_abnormal_respiratory_system0.80012507
115MP0005319_abnormal_enzyme/_coenzyme0.79909994
116MP0004885_abnormal_endolymph0.78328836
117MP0003303_peritoneal_inflammation0.78223968
118MP0002254_reproductive_system_inflammat0.77919094
119MP0002822_catalepsy0.77653438
120MP0009046_muscle_twitch0.77567069
121MP0001177_atelectasis0.76831574
122MP0002837_dystrophic_cardiac_calcinosis0.76517395
123MP0000249_abnormal_blood_vessel0.75995546
124MP0006082_CNS_inflammation0.75395146
125MP0002971_abnormal_brown_adipose0.74953426
126MP0005375_adipose_tissue_phenotype0.74921638
127MP0001299_abnormal_eye_distance/0.74610582
128MP0008961_abnormal_basal_metabolism0.74117591
129MP0003631_nervous_system_phenotype0.73959238
130MP0001533_abnormal_skeleton_physiology0.73822197
131MP0004484_altered_response_of0.73659783
132MP0004185_abnormal_adipocyte_glucose0.73158931
133MP0002572_abnormal_emotion/affect_behav0.72931350
134MP0005464_abnormal_platelet_physiology0.72660713
135MP0002928_abnormal_bile_duct0.72614708
136MP0001661_extended_life_span0.72318893
137MP0003283_abnormal_digestive_organ0.71496798
138MP0001243_abnormal_dermal_layer0.71474403
139MP0005167_abnormal_blood-brain_barrier0.70535882
140MP0003795_abnormal_bone_structure0.69827684
141MP0001851_eye_inflammation0.69420452
142MP0004084_abnormal_cardiac_muscle0.69364427
143MP0001502_abnormal_circadian_rhythm0.69040147
144MP0002796_impaired_skin_barrier0.69036485
145MP0001879_abnormal_lymphatic_vessel0.68574218
146MP0000538_abnormal_urinary_bladder0.68104296
147MP0004272_abnormal_basement_membrane0.67940809
148MP0005334_abnormal_fat_pad0.67336987
149MP0000639_abnormal_adrenal_gland0.66639518
150MP0001216_abnormal_epidermal_layer0.66626754
151MP0001542_abnormal_bone_strength0.66372636
152MP0005595_abnormal_vascular_smooth0.64376079
153MP0000462_abnormal_digestive_system0.63557947
154MP0000383_abnormal_hair_follicle0.63442096
155MP0003638_abnormal_response/metabolism_0.63079524
156MP0005386_behavior/neurological_phenoty0.62833473
157MP0004924_abnormal_behavior0.62833473
158MP0003953_abnormal_hormone_level0.62684225
159MP0002734_abnormal_mechanical_nocicepti0.61860436
160MP0003632_abnormal_nervous_system0.61771366
161MP0001440_abnormal_grooming_behavior0.61476329
162MP0005551_abnormal_eye_electrophysiolog0.59363477

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.05191442
2Deep venous thrombosis (HP:0002625)3.88220394
3Arterial tortuosity (HP:0005116)3.87012082
4Vascular tortuosity (HP:0004948)3.73202204
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69698286
6Aortic dissection (HP:0002647)3.63873699
7Neurofibrillary tangles (HP:0002185)3.52229311
8Protrusio acetabuli (HP:0003179)3.50983055
9Intrahepatic cholestasis (HP:0001406)3.41626863
10Abnormality of the common coagulation pathway (HP:0010990)3.39394012
11Xanthomatosis (HP:0000991)3.38671841
12Cerebral inclusion bodies (HP:0100314)3.33219805
13Abnormality of the intrinsic pathway (HP:0010989)3.29117295
14Fat malabsorption (HP:0002630)3.14152889
15Hyperlipoproteinemia (HP:0010980)3.13721585
16Ketosis (HP:0001946)3.09789851
17Abnormality of liposaccharide metabolism (HP:0010968)3.06152836
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.06152836
19Abnormality of glycolipid metabolism (HP:0010969)3.06152836
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.05234994
21Osteolytic defects of the hand bones (HP:0009699)3.05234994
22Aortic aneurysm (HP:0004942)3.05037885
23Supranuclear gaze palsy (HP:0000605)3.00081409
24Ketoacidosis (HP:0001993)2.97543075
25Dysostosis multiplex (HP:0000943)2.93328895
26Complement deficiency (HP:0004431)2.74445999
27Spondylolisthesis (HP:0003302)2.70498937
28Steatorrhea (HP:0002570)2.70283568
29Prolonged partial thromboplastin time (HP:0003645)2.65961136
30Mucopolysacchariduria (HP:0008155)2.60787775
31Urinary glycosaminoglycan excretion (HP:0003541)2.60787775
32Atrophic scars (HP:0001075)2.58219706
33Tetraparesis (HP:0002273)2.41551020
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40278502
35Abnormality of polysaccharide metabolism (HP:0011012)2.38072716
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38072716
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38072716
38Epidermoid cyst (HP:0200040)2.37841846
39Asymmetry of the thorax (HP:0001555)2.37826105
40Vertebral compression fractures (HP:0002953)2.37005705
41Hypoglycemic coma (HP:0001325)2.34938129
42Skin nodule (HP:0200036)2.34150649
43Myocardial infarction (HP:0001658)2.32886148
44Increased cerebral lipofuscin (HP:0011813)2.32132038
45Gout (HP:0001997)2.30499239
46Wormian bones (HP:0002645)2.29476797
47Papillary thyroid carcinoma (HP:0002895)2.28504432
48Hypoglycemic seizures (HP:0002173)2.27634069
49Peritonitis (HP:0002586)2.27048593
50Follicular hyperkeratosis (HP:0007502)2.26875360
51Dysmetric saccades (HP:0000641)2.24554410
52Conjugated hyperbilirubinemia (HP:0002908)2.24495765
53Cervical subluxation (HP:0003308)2.23700103
54Turricephaly (HP:0000262)2.19364279
55Dilatation of the ascending aorta (HP:0005111)2.19055137
56Flat acetabular roof (HP:0003180)2.16797520
57Cerebral aneurysm (HP:0004944)2.16057400
58Retinal atrophy (HP:0001105)2.12342272
59Glomerulonephritis (HP:0000099)2.07768575
60Intention tremor (HP:0002080)2.07012128
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06537973
62Ovoid vertebral bodies (HP:0003300)2.06195187
63Hypobetalipoproteinemia (HP:0003563)2.05775995
64Protuberant abdomen (HP:0001538)2.05682357
65Hypoalphalipoproteinemia (HP:0003233)2.04709784
66Amyloidosis (HP:0011034)2.02544517
67Right ventricular cardiomyopathy (HP:0011663)2.02434679
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.01541971
69Soft skin (HP:0000977)2.00718801
70Asymmetric septal hypertrophy (HP:0001670)2.00705241
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.99501041
72Infantile muscular hypotonia (HP:0008947)1.98866939
73Termporal pattern (HP:0011008)1.97750663
74Insidious onset (HP:0003587)1.97750663
75Systemic lupus erythematosus (HP:0002725)1.97227907
76Subacute progressive viral hepatitis (HP:0006572)1.97121670
77Action tremor (HP:0002345)1.96829870
78Hematochezia (HP:0002573)1.96724835
79Hyperinsulinemic hypoglycemia (HP:0000825)1.96510901
80Abnormality of sulfur amino acid metabolism (HP:0004339)1.96188605
81Ankyloglossia (HP:0010296)1.94637223
82Vacuolated lymphocytes (HP:0001922)1.93791179
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92582209
84Coarse hair (HP:0002208)1.91486298
85Hypolipoproteinemia (HP:0010981)1.91114063
86Mitral stenosis (HP:0001718)1.90213040
87Blue sclerae (HP:0000592)1.89507648
88Macroorchidism (HP:0000053)1.89310998
89Striae distensae (HP:0001065)1.88983560
90Fragile skin (HP:0001030)1.88498233
91Mitral valve prolapse (HP:0001634)1.87876664
92Status epilepticus (HP:0002133)1.87597762
93Hyperammonemia (HP:0001987)1.87271251
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87228781
95Abnormal foot bone ossification (HP:0010675)1.86874886
96Thin bony cortex (HP:0002753)1.84796247
97Sensorimotor neuropathy (HP:0007141)1.83399428
98Visual hallucinations (HP:0002367)1.83298254
99Absent frontal sinuses (HP:0002688)1.82619066
100Spinal cord lesions (HP:0100561)1.79765912
101Syringomyelia (HP:0003396)1.79765912
102Buphthalmos (HP:0000557)1.79432495
103Gingival bleeding (HP:0000225)1.77885543
104Ankle contracture (HP:0006466)1.76479204
105Neuronal loss in central nervous system (HP:0002529)1.76431186
106Abnormality of endocrine pancreas physiology (HP:0012093)1.76265505
107Abnormality of the pancreatic islet cells (HP:0006476)1.76265505
108Joint hemorrhage (HP:0005261)1.76223394
109Short nail (HP:0001799)1.76173800
110Periodontitis (HP:0000704)1.76091499
111Focal seizures (HP:0007359)1.75082694
112Hydroxyprolinuria (HP:0003080)1.74979294
113Abnormality of proline metabolism (HP:0010907)1.74979294
114Spastic gait (HP:0002064)1.74521150
115EEG with generalized epileptiform discharges (HP:0011198)1.74518234
116Cardiovascular calcification (HP:0011915)1.73824517
117Overgrowth (HP:0001548)1.73749485
118Epileptiform EEG discharges (HP:0011182)1.73658011
119Postural instability (HP:0002172)1.73281611
120Dysmetria (HP:0001310)1.72281350
121Hypsarrhythmia (HP:0002521)1.72040762
122Hypercholesterolemia (HP:0003124)1.72027780
123Type II lissencephaly (HP:0007260)1.71296933
124Hyperextensible skin (HP:0000974)1.70942511
125Hyperglycinemia (HP:0002154)1.70659702
126Abdominal distention (HP:0003270)1.70369822
127Nephritis (HP:0000123)1.69916924
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69621206
129Abnormality of the corticospinal tract (HP:0002492)1.69115722
130Axonal loss (HP:0003447)1.68817623
131Testicular neoplasm (HP:0010788)1.68796844
132Curly hair (HP:0002212)1.68724675
133Exocrine pancreatic insufficiency (HP:0001738)1.68494313
134Abnormality of complement system (HP:0005339)1.68045765
135Vascular calcification (HP:0004934)1.68019940
136Abnormality of glycine metabolism (HP:0010895)1.67979398
137Abnormality of serine family amino acid metabolism (HP:0010894)1.67979398
138Global brain atrophy (HP:0002283)1.67788835
139Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.67552162
140Abnormality of oral frenula (HP:0000190)1.67530966
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67445548
142Bladder diverticulum (HP:0000015)1.66503238
143Akinesia (HP:0002304)1.64815428
144Esophageal varix (HP:0002040)1.64554965
145Thickened calvaria (HP:0002684)1.64300459
146Thyroid carcinoma (HP:0002890)1.64088479
147Abnormality of the lumbar spine (HP:0100712)1.63763999
148Pancreatitis (HP:0001733)1.63719287
149Loss of speech (HP:0002371)1.63116947
150Abnormality of carpal bone ossification (HP:0006257)1.61457418
151Agitation (HP:0000713)1.61366982
152Hyperventilation (HP:0002883)1.60986083
153Bilateral sensorineural hearing impairment (HP:0008619)1.60633865
154Scanning speech (HP:0002168)1.60601321
155Cerebral hemorrhage (HP:0001342)1.60497970
156Abnormality of the Achilles tendon (HP:0005109)1.60290175
157Abnormality of purine metabolism (HP:0004352)1.59857690
158Abnormality of the acetabulum (HP:0003170)1.59495529
159Increased CSF protein (HP:0002922)1.58662566
160Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58555418
161Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58260950
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.58260950
163Malnutrition (HP:0004395)1.58207096
164Congenital glaucoma (HP:0001087)1.56823604
165Generalized tonic-clonic seizures (HP:0002069)1.55381469
166Symptomatic seizures (HP:0011145)1.54269729
167Aneurysm (HP:0002617)1.54132009
168Potter facies (HP:0002009)1.51960596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.98465037
2EIF2AK32.82997275
3AKT32.77811057
4NEK92.75294054
5BCKDK2.74829580
6TAOK32.48932139
7INSRR2.29637364
8TRPM72.24344134
9TRIB32.22092186
10NTRK32.12420582
11MAP3K22.09153470
12FRK2.03613440
13TGFBR21.94971517
14NTRK11.91634866
15EPHB11.89289697
16SIK11.84119818
17EPHA41.78200359
18KSR21.77871843
19RIPK11.75940771
20PRPF4B1.73529211
21MAP3K91.71509104
22MAP3K121.64316042
23DAPK21.59174446
24MYLK1.58431480
25STK391.55579215
26TYK21.51989873
27MAP3K41.50413564
28EIF2AK11.49021599
29CAMK1G1.48817144
30RIPK41.41889909
31MAP3K131.41824921
32PKN21.38087287
33BMPR21.36979853
34STK241.32941516
35RET1.32837789
36FGFR21.25710973
37MAP2K41.24901995
38YES11.23653837
39SGK21.21097668
40PAK61.20900935
41ERBB31.19542503
42SCYL21.16895226
43MET1.11121162
44DDR21.10718889
45PDGFRA1.09962170
46WNK41.09517973
47PTK61.09501458
48CAMK1D1.08828786
49MAP3K31.07220807
50CAMKK11.06856930
51EEF2K1.05676998
52PAK31.05108744
53MELK1.00898091
54PDPK10.99759690
55PRKCH0.99757595
56OXSR10.98332561
57LATS10.96863329
58LATS20.96725394
59PRKD30.91794082
60MST1R0.90981797
61PDGFRB0.90622527
62JAK10.89633804
63PAK40.89610009
64CDC42BPA0.89570250
65CDK50.88844037
66MAP3K70.88076923
67FER0.87948571
68FGFR40.87338078
69MAP3K10.86059337
70PTK20.84884719
71STK38L0.84619042
72MST40.83435249
73FES0.79104508
74ACVR1B0.78673134
75MARK10.78243903
76WNK10.77965538
77MINK10.77242508
78PDK10.76147957
79BRD40.75494900
80EPHA30.74949067
81MAP2K10.73954148
82NLK0.73923756
83PIK3CA0.73662412
84MAPK70.73453399
85ROCK20.72143452
86IRAK20.72112538
87JAK20.72045834
88PKN10.72030910
89FGR0.71522771
90CDK120.71187613
91CAMKK20.70429288
92STK30.70189902
93MAPKAPK30.69954786
94CDK60.69745974
95IRAK30.69616773
96PTK2B0.69026056
97TNIK0.68744636
98MAP2K20.67531745
99TBK10.65464930
100SGK4940.65282252
101SGK2230.65282252
102EPHA20.65161119
103BMX0.63655414
104TYRO30.62553102
105PRKCZ0.61808668
106ICK0.61561894
107PRKG20.61109097
108PAK20.58002505
109BLK0.57990953
110FYN0.57917631
111PHKG10.57225887
112PHKG20.57225887
113CAMK2D0.56795395
114CAMK2A0.56733653
115STK380.56238968
116PRKD10.56045407
117MARK20.55477858
118CAMK2B0.54719131
119LMTK20.54036517
120CSNK1G20.52946745
121HIPK20.52805617
122MAP3K140.52556613
123PRKCE0.51283878
124RPS6KB10.51191330
125SGK30.51030290
126MAP3K50.50922235
127PRKCQ0.50712627
128IKBKE0.50147435
129SGK10.50044154
130MOS0.48213900
131TAF10.48157515
132ZAP700.47425631
133MAP3K60.46626991
134NEK60.46608715
135GRK50.46542827
136MAP2K30.46109733
137MAPK150.46106779
138CSK0.45740562
139FGFR30.45575182
140PRKAA20.45349179
141MAP2K70.45144967
142PIK3CG0.44688458
143JAK30.44535001
144TTN0.44111037
145SIK20.43382288
146CAMK2G0.43089386
147ERBB40.42101471
148MTOR0.41567549
149DMPK0.41229007
150KSR10.40987267
151IGF1R0.40061670

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.92313735
2Pancreatic secretion_Homo sapiens_hsa049722.32373706
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.22921488
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92870863
5Fat digestion and absorption_Homo sapiens_hsa049751.90549319
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.73150223
7Arginine biosynthesis_Homo sapiens_hsa002201.67520463
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61990590
9Sulfur metabolism_Homo sapiens_hsa009201.53800865
10Protein digestion and absorption_Homo sapiens_hsa049741.53053407
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47041780
12* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46374585
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39025710
14Protein export_Homo sapiens_hsa030601.38339217
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36260133
16Sphingolipid metabolism_Homo sapiens_hsa006001.36235535
17Butanoate metabolism_Homo sapiens_hsa006501.32778010
18ECM-receptor interaction_Homo sapiens_hsa045121.32089796
19Steroid biosynthesis_Homo sapiens_hsa001001.31946271
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30165711
21Focal adhesion_Homo sapiens_hsa045101.29658889
22Tryptophan metabolism_Homo sapiens_hsa003801.28924626
23Bile secretion_Homo sapiens_hsa049761.25546092
24Complement and coagulation cascades_Homo sapiens_hsa046101.25010416
25Fatty acid degradation_Homo sapiens_hsa000711.21078957
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19397081
27Glycerolipid metabolism_Homo sapiens_hsa005611.18160311
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14565272
29Propanoate metabolism_Homo sapiens_hsa006401.13912718
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12916284
31Proteoglycans in cancer_Homo sapiens_hsa052051.11525356
32Insulin secretion_Homo sapiens_hsa049111.10861529
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07263934
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04225325
35Fatty acid metabolism_Homo sapiens_hsa012121.03209995
36GABAergic synapse_Homo sapiens_hsa047271.03154639
37PPAR signaling pathway_Homo sapiens_hsa033201.00591283
38Inositol phosphate metabolism_Homo sapiens_hsa005620.96213557
39mTOR signaling pathway_Homo sapiens_hsa041500.92787126
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92210284
41Type II diabetes mellitus_Homo sapiens_hsa049300.91569786
42Thyroid hormone synthesis_Homo sapiens_hsa049180.89652067
43Starch and sucrose metabolism_Homo sapiens_hsa005000.88866081
44Renal cell carcinoma_Homo sapiens_hsa052110.87891654
45Endometrial cancer_Homo sapiens_hsa052130.87220403
46Prostate cancer_Homo sapiens_hsa052150.86516267
47Pancreatic cancer_Homo sapiens_hsa052120.86109639
48Salivary secretion_Homo sapiens_hsa049700.85895822
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84899226
50Histidine metabolism_Homo sapiens_hsa003400.84876194
51Lysosome_Homo sapiens_hsa041420.84819178
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84194593
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83796295
54Renin secretion_Homo sapiens_hsa049240.83792289
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83463633
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83343766
57Small cell lung cancer_Homo sapiens_hsa052220.81803864
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81659268
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81621118
60Adherens junction_Homo sapiens_hsa045200.81140891
61Glutamatergic synapse_Homo sapiens_hsa047240.80561962
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.80204187
63Caffeine metabolism_Homo sapiens_hsa002320.79419266
64Long-term potentiation_Homo sapiens_hsa047200.79348228
65Staphylococcus aureus infection_Homo sapiens_hsa051500.78477599
66Peroxisome_Homo sapiens_hsa041460.78408756
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76755287
68Retinol metabolism_Homo sapiens_hsa008300.76667716
69Non-small cell lung cancer_Homo sapiens_hsa052230.76523081
70Circadian rhythm_Homo sapiens_hsa047100.76398458
71Vibrio cholerae infection_Homo sapiens_hsa051100.76269433
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75776365
73Circadian entrainment_Homo sapiens_hsa047130.75659371
74Prion diseases_Homo sapiens_hsa050200.74679493
75ABC transporters_Homo sapiens_hsa020100.74490740
76Nicotine addiction_Homo sapiens_hsa050330.74011482
77Hepatitis C_Homo sapiens_hsa051600.73848849
78Cocaine addiction_Homo sapiens_hsa050300.73784600
79Toxoplasmosis_Homo sapiens_hsa051450.73503714
80Mineral absorption_Homo sapiens_hsa049780.72620348
81Prolactin signaling pathway_Homo sapiens_hsa049170.72240330
82Gastric acid secretion_Homo sapiens_hsa049710.72010368
83Chronic myeloid leukemia_Homo sapiens_hsa052200.71448035
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71030486
85Synaptic vesicle cycle_Homo sapiens_hsa047210.70436230
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69963862
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68555944
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.68344766
89Amphetamine addiction_Homo sapiens_hsa050310.68163115
90N-Glycan biosynthesis_Homo sapiens_hsa005100.67230929
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66057192
92Pertussis_Homo sapiens_hsa051330.65842688
93Osteoclast differentiation_Homo sapiens_hsa043800.65457187
94beta-Alanine metabolism_Homo sapiens_hsa004100.65175190
95Cholinergic synapse_Homo sapiens_hsa047250.64693386
96Phagosome_Homo sapiens_hsa041450.64327003
97Platelet activation_Homo sapiens_hsa046110.64185253
98TNF signaling pathway_Homo sapiens_hsa046680.63892662
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63838387
100Vitamin digestion and absorption_Homo sapiens_hsa049770.63153948
101Morphine addiction_Homo sapiens_hsa050320.63120039
102Fatty acid elongation_Homo sapiens_hsa000620.62555420
103FoxO signaling pathway_Homo sapiens_hsa040680.61783833
104Dopaminergic synapse_Homo sapiens_hsa047280.61363899
105Malaria_Homo sapiens_hsa051440.61332058
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60281956
107Thyroid cancer_Homo sapiens_hsa052160.59047926
108Insulin resistance_Homo sapiens_hsa049310.56539036
109Hepatitis B_Homo sapiens_hsa051610.56154762
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55353858
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.54637384
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.54172989
113Tuberculosis_Homo sapiens_hsa051520.53493717
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53327933
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.52455718
116Long-term depression_Homo sapiens_hsa047300.52167059
117Estrogen signaling pathway_Homo sapiens_hsa049150.51364120
118GnRH signaling pathway_Homo sapiens_hsa049120.51185760
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50965033
120Pyruvate metabolism_Homo sapiens_hsa006200.50169345
121Influenza A_Homo sapiens_hsa051640.49641694
122Chemical carcinogenesis_Homo sapiens_hsa052040.49107259
123Fructose and mannose metabolism_Homo sapiens_hsa000510.48906864
124HIF-1 signaling pathway_Homo sapiens_hsa040660.48890427
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48531949
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48198060
127Choline metabolism in cancer_Homo sapiens_hsa052310.47729488
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47500073
129Folate biosynthesis_Homo sapiens_hsa007900.47242371
130Fatty acid biosynthesis_Homo sapiens_hsa000610.46729887
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.45883236
132Phenylalanine metabolism_Homo sapiens_hsa003600.45682004
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45280978
134AMPK signaling pathway_Homo sapiens_hsa041520.45150374
135Dorso-ventral axis formation_Homo sapiens_hsa043200.44227813
136cAMP signaling pathway_Homo sapiens_hsa040240.43881725
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43149506
138Arginine and proline metabolism_Homo sapiens_hsa003300.42922381
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.42872186
140Other glycan degradation_Homo sapiens_hsa005110.42238359
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40585242
142Calcium signaling pathway_Homo sapiens_hsa040200.39498184
143Glioma_Homo sapiens_hsa052140.39012386
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38554896
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.38424957
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37675419
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.37420286
148Amoebiasis_Homo sapiens_hsa051460.37407486
149Renin-angiotensin system_Homo sapiens_hsa046140.36278772
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36132693
151Oxytocin signaling pathway_Homo sapiens_hsa049210.35861749

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