SEH1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.44732923
2negative regulation of translation, ncRNA-mediated (GO:0040033)6.44732923
3regulation of translation, ncRNA-mediated (GO:0045974)6.44732923
4regulation of DNA endoreduplication (GO:0032875)4.78795135
5nucleobase biosynthetic process (GO:0046112)4.60947752
6protein localization to kinetochore (GO:0034501)4.55689129
7DNA unwinding involved in DNA replication (GO:0006268)4.52049080
8RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.47914842
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.46698089
10purine nucleobase biosynthetic process (GO:0009113)4.45971584
11* mitotic metaphase plate congression (GO:0007080)4.37756953
12DNA strand elongation involved in DNA replication (GO:0006271)4.27552833
13folic acid-containing compound biosynthetic process (GO:0009396)4.20128843
14formation of translation preinitiation complex (GO:0001731)4.18884202
15DNA replication initiation (GO:0006270)4.18507286
16establishment of integrated proviral latency (GO:0075713)4.16811862
17DNA strand elongation (GO:0022616)4.10444926
18DNA catabolic process, exonucleolytic (GO:0000738)4.09066943
19* mitotic nuclear envelope disassembly (GO:0007077)4.07063073
20proteasome assembly (GO:0043248)4.01443480
21* nuclear pore organization (GO:0006999)3.96093815
22telomere maintenance via semi-conservative replication (GO:0032201)3.95570552
23IMP biosynthetic process (GO:0006188)3.95121694
24DNA replication checkpoint (GO:0000076)3.94420197
25CENP-A containing nucleosome assembly (GO:0034080)3.88918491
26DNA replication-dependent nucleosome organization (GO:0034723)3.85640314
27DNA replication-dependent nucleosome assembly (GO:0006335)3.85640314
28pteridine-containing compound biosynthetic process (GO:0042559)3.85636733
29chromatin remodeling at centromere (GO:0031055)3.84028690
30ribosome assembly (GO:0042255)3.82796208
31* metaphase plate congression (GO:0051310)3.79961980
32protein localization to chromosome, centromeric region (GO:0071459)3.78037472
33* nuclear envelope disassembly (GO:0051081)3.76076907
34* membrane disassembly (GO:0030397)3.76076907
35nuclear pore complex assembly (GO:0051292)3.75411347
36telomere maintenance via recombination (GO:0000722)3.67814529
37mitotic sister chromatid segregation (GO:0000070)3.66011296
38mitotic chromosome condensation (GO:0007076)3.65825641
39positive regulation of chromosome segregation (GO:0051984)3.62512248
40mitotic recombination (GO:0006312)3.61274539
41kinetochore organization (GO:0051383)3.61230330
42DNA replication-independent nucleosome assembly (GO:0006336)3.61016586
43DNA replication-independent nucleosome organization (GO:0034724)3.61016586
44ribosome biogenesis (GO:0042254)3.53275101
45regulation of spindle organization (GO:0090224)3.52410286
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48839416
47sister chromatid segregation (GO:0000819)3.48741810
48IMP metabolic process (GO:0046040)3.44215500
49methionine biosynthetic process (GO:0009086)3.43987957
50maturation of SSU-rRNA (GO:0030490)3.43032757
51DNA double-strand break processing (GO:0000729)3.41827130
52protein K11-linked deubiquitination (GO:0035871)3.41292640
53pseudouridine synthesis (GO:0001522)3.40743022
54telomere maintenance via telomere lengthening (GO:0010833)3.34512016
55maturation of 5.8S rRNA (GO:0000460)3.32944539
56termination of RNA polymerase III transcription (GO:0006386)3.32411086
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.32411086
58resolution of meiotic recombination intermediates (GO:0000712)3.32261772
59ribosomal small subunit assembly (GO:0000028)3.32184613
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32033735
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.29230410
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.29230410
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.29230410
64* establishment of chromosome localization (GO:0051303)3.28363525
65histone exchange (GO:0043486)3.27020846
66* attachment of spindle microtubules to kinetochore (GO:0008608)3.26538832
67replication fork processing (GO:0031297)3.23838138
68mitotic sister chromatid cohesion (GO:0007064)3.22141266
69DNA geometric change (GO:0032392)3.21952307
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21300248
71DNA duplex unwinding (GO:0032508)3.21105192
72entrainment of circadian clock by photoperiod (GO:0043153)3.20174399
73spindle checkpoint (GO:0031577)3.19355589
74negative regulation of chromosome segregation (GO:0051985)3.19018714
75mitochondrial RNA metabolic process (GO:0000959)3.18937916
76heart contraction (GO:0060047)3.17802179
77heart process (GO:0003015)3.17802179
78regulation of chromosome segregation (GO:0051983)3.16743623
79ribonucleoprotein complex biogenesis (GO:0022613)3.15688242
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15660743
81kinetochore assembly (GO:0051382)3.14363130
82meiotic chromosome segregation (GO:0045132)3.14237722
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13612359
84negative regulation of sister chromatid segregation (GO:0033046)3.13612359
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.13612359
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13612359
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.13564281
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.13564281
89isotype switching (GO:0045190)3.13564281
90regulation of sister chromatid cohesion (GO:0007063)3.12456274
91regulation of gene silencing by miRNA (GO:0060964)3.10758054
92regulation of gene silencing by RNA (GO:0060966)3.10758054
93regulation of posttranscriptional gene silencing (GO:0060147)3.10758054
94establishment of viral latency (GO:0019043)3.10694572
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.10427344
96spindle assembly checkpoint (GO:0071173)3.09984747
97ribosomal large subunit biogenesis (GO:0042273)3.09014660
98motile cilium assembly (GO:0044458)3.08909622
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08628118
100non-recombinational repair (GO:0000726)3.08441045
101double-strand break repair via nonhomologous end joining (GO:0006303)3.08441045
102transcription elongation from RNA polymerase I promoter (GO:0006362)3.07408552
103mitotic spindle checkpoint (GO:0071174)3.06940257
104mitotic spindle assembly checkpoint (GO:0007094)3.06650205
105protein K6-linked ubiquitination (GO:0085020)3.05879296
106histone mRNA metabolic process (GO:0008334)3.05177976
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04571561
108somatic hypermutation of immunoglobulin genes (GO:0016446)3.03081894
109somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03081894
110regulation of centrosome cycle (GO:0046605)3.02826346
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01573915
112sister chromatid cohesion (GO:0007062)3.01279898
113methionine metabolic process (GO:0006555)2.99596812
114aspartate family amino acid biosynthetic process (GO:0009067)2.99107590
115regulation of hippo signaling (GO:0035330)2.98739648
116regulation of sister chromatid segregation (GO:0033045)2.98364389
117regulation of mitotic sister chromatid separation (GO:0010965)2.98364389
118regulation of mitotic sister chromatid segregation (GO:0033047)2.98364389
119folic acid metabolic process (GO:0046655)2.98348370
120amino acid activation (GO:0043038)2.97621990
121tRNA aminoacylation (GO:0043039)2.97621990
122protein localization to chromosome (GO:0034502)2.96908246
123regulation of centriole replication (GO:0046599)2.94659257
124synapsis (GO:0007129)2.94560567
125chromatin assembly or disassembly (GO:0006333)2.92999329
126regulation of mitotic spindle organization (GO:0060236)2.92772843
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92126677
128chromosome segregation (GO:0007059)2.91537683
129spliceosomal snRNP assembly (GO:0000387)2.91404065
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.91400061
131* nuclear envelope organization (GO:0006998)2.91023967
132somatic recombination of immunoglobulin gene segments (GO:0016447)2.90277618
133termination of RNA polymerase I transcription (GO:0006363)2.88889502
134tRNA aminoacylation for protein translation (GO:0006418)2.88812976
135imidazole-containing compound metabolic process (GO:0052803)2.88607913
136entrainment of circadian clock (GO:0009649)2.86208724
137sulfur amino acid biosynthetic process (GO:0000097)2.85967186
138tetrahydrofolate metabolic process (GO:0046653)2.85494818
139pre-miRNA processing (GO:0031054)2.84898148
140nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84384506
141DNA-templated transcription, termination (GO:0006353)2.82539986
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82169142
143regulation of helicase activity (GO:0051095)2.81069934
144ATP-dependent chromatin remodeling (GO:0043044)2.80911945
145centriole assembly (GO:0098534)2.80861930
146rRNA processing (GO:0006364)2.80346210
147RNA phosphodiester bond hydrolysis (GO:0090501)2.79717370
148transcription from mitochondrial promoter (GO:0006390)2.79628931
149telomere maintenance (GO:0000723)2.79512749
150regulation of translational fidelity (GO:0006450)2.79266440
151telomere organization (GO:0032200)2.78084379
152peptidyl-histidine modification (GO:0018202)2.77756049
153pore complex assembly (GO:0046931)2.76879929
154somatic diversification of immunoglobulins (GO:0016445)2.76569234
1557-methylguanosine mRNA capping (GO:0006370)2.76135557
156translational initiation (GO:0006413)2.75943116
157regulation of mitotic spindle checkpoint (GO:1903504)2.75907596
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75907596
159transcription-coupled nucleotide-excision repair (GO:0006283)2.74947326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57779864
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.29302343
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.18922409
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79673640
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40606019
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25977936
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97674809
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80979316
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80226302
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.68482990
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56967392
12AR_21909140_ChIP-Seq_LNCAP_Human2.51014610
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44310889
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43486285
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.42636001
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.40980679
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.39733615
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39639426
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30067159
20XRN2_22483619_ChIP-Seq_HELA_Human2.20974454
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16164189
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12301888
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.07357576
24ZNF274_21170338_ChIP-Seq_K562_Hela2.06978028
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03877028
26EWS_26573619_Chip-Seq_HEK293_Human1.98934575
27VDR_23849224_ChIP-Seq_CD4+_Human1.98391126
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97446312
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95170075
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93774887
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93051474
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91319304
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85751058
34FOXP3_21729870_ChIP-Seq_TREG_Human1.82584555
35DCP1A_22483619_ChIP-Seq_HELA_Human1.82207154
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74854122
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73998316
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.72826704
39VDR_22108803_ChIP-Seq_LS180_Human1.69928261
40* GABP_19822575_ChIP-Seq_HepG2_Human1.69175709
41TTF2_22483619_ChIP-Seq_HELA_Human1.67716855
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65208596
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.63659965
44IGF1R_20145208_ChIP-Seq_DFB_Human1.63163190
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61270972
46ELK1_19687146_ChIP-ChIP_HELA_Human1.61185972
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59394349
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54100415
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.54005856
50* MYC_22102868_ChIP-Seq_BL_Human1.52428546
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48471975
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48265987
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46750478
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46435870
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.45609697
56KDM5A_27292631_Chip-Seq_BREAST_Human1.44797137
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43544071
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42740765
59FUS_26573619_Chip-Seq_HEK293_Human1.42202858
60ELF5_23300383_ChIP-Seq_T47D_Human1.41059735
61CIITA_25753668_ChIP-Seq_RAJI_Human1.39719663
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38960005
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36643391
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35597309
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33263831
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32755726
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30705583
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29248363
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28178781
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28120404
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25025941
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23567299
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23120410
74TFEB_21752829_ChIP-Seq_HELA_Human1.21728519
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18102267
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.18051029
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.17794740
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13573100
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11565259
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10919991
81* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10512482
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10114543
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09719283
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.09294522
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08904758
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08648024
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08276153
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08276153
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08276153
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06294579
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05343810
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03511981
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03040869
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01376574
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99994689
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98734729
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.96137561
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96024399
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95556127
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94496727
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94001778
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93359564
103* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92807809
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92053478
105P300_19829295_ChIP-Seq_ESCs_Human0.90489777
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90424258
107MYC_18940864_ChIP-ChIP_HL60_Human0.88469906
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87618112
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86045623
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85697049
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85476349
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84428665
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84025150
114CHD1_26751641_Chip-Seq_LNCaP_Human0.83611030
115* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83456090
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83228786
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83130906
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82227769
119* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81952407
120TAF15_26573619_Chip-Seq_HEK293_Human0.81126541
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.80863613
122* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80754088
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74214420
124ER_23166858_ChIP-Seq_MCF-7_Human0.73804934
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72165167
126* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71822084
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.70853942
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70566146
129CBP_20019798_ChIP-Seq_JUKART_Human0.70566146
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.70562779
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70298572
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70161046
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69385062
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68964685
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68306077
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68249313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86581853
2MP0004957_abnormal_blastocyst_morpholog4.19264199
3MP0010094_abnormal_chromosome_stability4.08054673
4MP0003111_abnormal_nucleus_morphology3.87828088
5MP0003077_abnormal_cell_cycle3.55233805
6MP0008789_abnormal_olfactory_epithelium3.44099973
7MP0008057_abnormal_DNA_replication3.41835835
8MP0003123_paternal_imprinting2.97835624
9MP0008007_abnormal_cellular_replicative2.77037595
10MP0001529_abnormal_vocalization2.63495765
11MP0008058_abnormal_DNA_repair2.56706339
12MP0010352_gastrointestinal_tract_polyps2.53284568
13MP0005499_abnormal_olfactory_system2.36747203
14MP0005394_taste/olfaction_phenotype2.36747203
15MP0008932_abnormal_embryonic_tissue2.32991884
16MP0001730_embryonic_growth_arrest2.32457135
17MP0000350_abnormal_cell_proliferation2.12750729
18MP0010307_abnormal_tumor_latency2.04324361
19MP0003950_abnormal_plasma_membrane1.87002325
20MP0005380_embryogenesis_phenotype1.86970283
21MP0001672_abnormal_embryogenesis/_devel1.86970283
22MP0002396_abnormal_hematopoietic_system1.86649623
23MP0003806_abnormal_nucleotide_metabolis1.83516457
24MP0001697_abnormal_embryo_size1.81830871
25MP0003567_abnormal_fetal_cardiomyocyte1.73542022
26MP0003984_embryonic_growth_retardation1.71535675
27MP0002088_abnormal_embryonic_growth/wei1.68535082
28MP0004197_abnormal_fetal_growth/weight/1.65891351
29MP0002084_abnormal_developmental_patter1.63137958
30MP0003890_abnormal_embryonic-extraembry1.63074554
31MP0002102_abnormal_ear_morphology1.62801138
32MP0002080_prenatal_lethality1.61468393
33MP0003786_premature_aging1.60823333
34MP0002086_abnormal_extraembryonic_tissu1.58936831
35MP0002085_abnormal_embryonic_tissue1.58623620
36MP0003705_abnormal_hypodermis_morpholog1.49486686
37MP0010030_abnormal_orbit_morphology1.44545806
38MP0001485_abnormal_pinna_reflex1.42917602
39MP0003718_maternal_effect1.41861591
40MP0005076_abnormal_cell_differentiation1.41157668
41MP0003121_genomic_imprinting1.38246934
42MP0006072_abnormal_retinal_apoptosis1.37298676
43MP0004808_abnormal_hematopoietic_stem1.36922127
44MP0008877_abnormal_DNA_methylation1.36562682
45MP0000490_abnormal_crypts_of1.36540875
46MP0001293_anophthalmia1.32658810
47MP0009053_abnormal_anal_canal1.29719328
48MP0002233_abnormal_nose_morphology1.28344959
49MP0002019_abnormal_tumor_incidence1.23526905
50MP0009672_abnormal_birth_weight1.23501756
51MP0000313_abnormal_cell_death1.23079653
52MP0006054_spinal_hemorrhage1.21441910
53MP0003941_abnormal_skin_development1.20579351
54MP0003828_pulmonary_edema1.15494370
55MP0005332_abnormal_amino_acid1.15401590
56MP0000372_irregular_coat_pigmentation1.13830928
57MP0006292_abnormal_olfactory_placode1.11494716
58MP0003119_abnormal_digestive_system1.11471475
59MP0002009_preneoplasia1.09842546
60MP0003315_abnormal_perineum_morphology1.07127760
61MP0004264_abnormal_extraembryonic_tissu1.05797489
62MP0005253_abnormal_eye_physiology1.05450139
63MP0002163_abnormal_gland_morphology1.03203840
64MP0009333_abnormal_splenocyte_physiolog1.02406192
65MP0003221_abnormal_cardiomyocyte_apopto1.01862186
66MP0006035_abnormal_mitochondrial_morpho1.00229761
67MP0003566_abnormal_cell_adhesion0.97759970
68MP0000537_abnormal_urethra_morphology0.97665155
69MP0001849_ear_inflammation0.95458894
70MP0002111_abnormal_tail_morphology0.94679126
71MP0005395_other_phenotype0.94501013
72MP0001545_abnormal_hematopoietic_system0.92158890
73MP0005397_hematopoietic_system_phenotyp0.92158890
74MP0009703_decreased_birth_body0.91588978
75MP0002877_abnormal_melanocyte_morpholog0.90597663
76MP0006276_abnormal_autonomic_nervous0.90074276
77MP0004145_abnormal_muscle_electrophysio0.89333030
78MP0000427_abnormal_hair_cycle0.88877982
79MP0002210_abnormal_sex_determination0.87803337
80MP0000516_abnormal_urinary_system0.86517392
81MP0005367_renal/urinary_system_phenotyp0.86517392
82MP0005023_abnormal_wound_healing0.85225442
83MP0001915_intracranial_hemorrhage0.84756825
84MP0003698_abnormal_male_reproductive0.84589425
85MP0003186_abnormal_redox_activity0.83573421
86MP0002139_abnormal_hepatobiliary_system0.82503055
87MP0003937_abnormal_limbs/digits/tail_de0.82377189
88MP0001119_abnormal_female_reproductive0.80946649
89MP0002751_abnormal_autonomic_nervous0.80910376
90MP0002092_abnormal_eye_morphology0.80908001
91MP0009697_abnormal_copulation0.80308694
92MP0008872_abnormal_physiological_respon0.79932135
93MP0001145_abnormal_male_reproductive0.78895614
94MP0000428_abnormal_craniofacial_morphol0.76861194
95MP0000703_abnormal_thymus_morphology0.75573489
96MP0004147_increased_porphyrin_level0.75191640
97MP0000678_abnormal_parathyroid_gland0.74157262
98MP0003763_abnormal_thymus_physiology0.73283088
99MP0004133_heterotaxia0.72501644
100MP0000598_abnormal_liver_morphology0.72420578
101MP0004215_abnormal_myocardial_fiber0.71596829
102MP0005384_cellular_phenotype0.71448783
103MP0000358_abnormal_cell_content/0.71422575
104MP0002837_dystrophic_cardiac_calcinosis0.71298233
105MP0002938_white_spotting0.70365613
106MP0000749_muscle_degeneration0.70124615
107MP0000653_abnormal_sex_gland0.70031571
108MP0008875_abnormal_xenobiotic_pharmacok0.69147227
109MP0005220_abnormal_exocrine_pancreas0.68554518
110MP0003943_abnormal_hepatobiliary_system0.68144951
111MP0002722_abnormal_immune_system0.67860511
112MP0000049_abnormal_middle_ear0.67787070
113MP0008770_decreased_survivor_rate0.67725173
114MP0005621_abnormal_cell_physiology0.67630562
115MP0010234_abnormal_vibrissa_follicle0.67463728
116MP0001286_abnormal_eye_development0.67135734
117MP0001919_abnormal_reproductive_system0.66626050
118MP0001764_abnormal_homeostasis0.66571223
119MP0000858_altered_metastatic_potential0.64798132
120MP0000689_abnormal_spleen_morphology0.64500850
121MP0000432_abnormal_head_morphology0.64313841
122MP0002398_abnormal_bone_marrow0.63989206
123MP0003787_abnormal_imprinting0.63460877
124MP0000477_abnormal_intestine_morphology0.63319106
125MP0000647_abnormal_sebaceous_gland0.63295712
126MP0002234_abnormal_pharynx_morphology0.63073142
127MP0002090_abnormal_vision0.62382681
128MP0002160_abnormal_reproductive_system0.61848767
129MP0002127_abnormal_cardiovascular_syste0.61404050
130MP0003935_abnormal_craniofacial_develop0.60988269
131MP0005389_reproductive_system_phenotype0.60776490
132MP0005645_abnormal_hypothalamus_physiol0.60580455
133MP0001784_abnormal_fluid_regulation0.60043159
134MP0002925_abnormal_cardiovascular_devel0.59768513
135MP0003385_abnormal_body_wall0.59629805
136MP0006036_abnormal_mitochondrial_physio0.59194301
137MP0002095_abnormal_skin_pigmentation0.59022175
138MP0001853_heart_inflammation0.58590735
139MP0002161_abnormal_fertility/fecundity0.58270673
140MP0003942_abnormal_urinary_system0.56436368
141MP0004084_abnormal_cardiac_muscle0.55656558
142MP0002697_abnormal_eye_size0.55491874
143MP0009278_abnormal_bone_marrow0.54523474
144MP0001929_abnormal_gametogenesis0.53912144

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.92710817
2Colon cancer (HP:0003003)3.85479399
3Breast hypoplasia (HP:0003187)3.68492882
4Cholecystitis (HP:0001082)3.60660766
5Abnormal gallbladder physiology (HP:0012438)3.60660766
6Selective tooth agenesis (HP:0001592)3.39446908
7Ependymoma (HP:0002888)3.37293726
8Abnormality of the anterior horn cell (HP:0006802)3.27461015
9Degeneration of anterior horn cells (HP:0002398)3.27461015
10Chromsome breakage (HP:0040012)3.23773060
11Medulloblastoma (HP:0002885)3.22306438
12Oral leukoplakia (HP:0002745)3.20581554
13Reticulocytopenia (HP:0001896)3.11514419
14Type 2 muscle fiber atrophy (HP:0003554)3.09519454
15Patellar aplasia (HP:0006443)3.07646541
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04421709
17Aplasia/Hypoplasia of the patella (HP:0006498)2.93138112
18Abnormality of alanine metabolism (HP:0010916)2.91668112
19Hyperalaninemia (HP:0003348)2.91668112
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91668112
21Abnormality of chromosome stability (HP:0003220)2.90380609
22Impulsivity (HP:0100710)2.83104031
23Aplastic anemia (HP:0001915)2.83074341
24B lymphocytopenia (HP:0010976)2.75635112
25Carpal bone hypoplasia (HP:0001498)2.75227728
26Rhabdomyosarcoma (HP:0002859)2.74854854
27Abnormality of the pons (HP:0007361)2.72638413
28Meckel diverticulum (HP:0002245)2.71919251
29Neoplasm of the adrenal cortex (HP:0100641)2.71880725
30Hypoplasia of the pons (HP:0012110)2.70512471
31Dyschromatopsia (HP:0007641)2.60677264
32Abnormality of B cell number (HP:0010975)2.58803364
33Muscle fiber atrophy (HP:0100295)2.58549736
34Abnormality of the ileum (HP:0001549)2.57904144
35Abnormality of the preputium (HP:0100587)2.55194354
36Absent thumb (HP:0009777)2.54248762
37Abnormality of DNA repair (HP:0003254)2.52826463
38Rough bone trabeculation (HP:0100670)2.52443946
39Absent radius (HP:0003974)2.52160253
40Myelodysplasia (HP:0002863)2.45337470
41Neoplasm of the pancreas (HP:0002894)2.43525618
42Multiple enchondromatosis (HP:0005701)2.39295676
43Agnosia (HP:0010524)2.37584929
44Abnormality of pyrimidine metabolism (HP:0004353)2.37426240
45Abnormal number of incisors (HP:0011064)2.37370004
46Abnormal lung lobation (HP:0002101)2.36748927
47Supernumerary spleens (HP:0009799)2.36329729
48Small intestinal stenosis (HP:0012848)2.36242978
49Duodenal stenosis (HP:0100867)2.36242978
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.34386778
51Amniotic constriction ring (HP:0009775)2.32307131
52Abnormality of placental membranes (HP:0011409)2.32307131
5311 pairs of ribs (HP:0000878)2.32043769
54Abnormality of cells of the erythroid lineage (HP:0012130)2.31793855
55Atresia of the external auditory canal (HP:0000413)2.30089367
56Aplasia/hypoplasia of the humerus (HP:0006507)2.27891834
57Missing ribs (HP:0000921)2.27263144
58Aplasia involving forearm bones (HP:0009822)2.27088527
59Absent forearm bone (HP:0003953)2.27088527
60Pancreatic cysts (HP:0001737)2.26761064
61Abnormality of the labia minora (HP:0012880)2.26722376
62Abnormality of the carotid arteries (HP:0005344)2.26333918
63Deviation of the thumb (HP:0009603)2.26269435
64Neoplasm of the adrenal gland (HP:0100631)2.25324234
65Neoplasm of the colon (HP:0100273)2.24983427
66Sensory axonal neuropathy (HP:0003390)2.24610081
67Proximal placement of thumb (HP:0009623)2.23984637
68Clubbing of toes (HP:0100760)2.22993284
69Type II lissencephaly (HP:0007260)2.16589271
70Increased nuchal translucency (HP:0010880)2.16122889
71Abnormal number of erythroid precursors (HP:0012131)2.15867166
72Abnormality of the duodenum (HP:0002246)2.15015715
73Abnormality of sulfur amino acid metabolism (HP:0004339)2.13758707
74Bone marrow hypocellularity (HP:0005528)2.12559118
75Volvulus (HP:0002580)2.11534620
76Microretrognathia (HP:0000308)2.09424935
77Biliary tract neoplasm (HP:0100574)2.08842989
78Shoulder girdle muscle weakness (HP:0003547)2.08205182
79Ovarian neoplasm (HP:0100615)2.08086382
80Trismus (HP:0000211)2.07558733
81Cellular immunodeficiency (HP:0005374)2.06986321
82Amaurosis fugax (HP:0100576)2.06580017
83Pancreatic fibrosis (HP:0100732)2.05123131
84Abnormality of the astrocytes (HP:0100707)2.04771472
85Astrocytoma (HP:0009592)2.04771472
86Ectopic kidney (HP:0000086)2.04150065
87Popliteal pterygium (HP:0009756)2.03444760
88Acute lymphatic leukemia (HP:0006721)2.03120484
89Short humerus (HP:0005792)2.01203055
90Palpitations (HP:0001962)2.00970684
91Stenosis of the external auditory canal (HP:0000402)2.00586498
92Abnormal trabecular bone morphology (HP:0100671)1.99948968
93Increased hepatocellular lipid droplets (HP:0006565)1.98039328
94Basal cell carcinoma (HP:0002671)1.96996011
95Glioma (HP:0009733)1.96613845
96Sloping forehead (HP:0000340)1.96335241
97Arteriovenous malformation (HP:0100026)1.95218931
98Cafe-au-lait spot (HP:0000957)1.92786582
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.92765316
100Cerebellar dysplasia (HP:0007033)1.92182387
101Neoplasm of striated muscle (HP:0009728)1.91640644
102Abnormal biliary tract morphology (HP:0012440)1.90095953
103Neoplasm of the rectum (HP:0100743)1.88945323
104Spastic paraparesis (HP:0002313)1.88393039
105Microvesicular hepatic steatosis (HP:0001414)1.88258998
106Intestinal polyposis (HP:0200008)1.88247922
107Lipid accumulation in hepatocytes (HP:0006561)1.87949430
108Intestinal polyp (HP:0005266)1.87669334
109Spastic diplegia (HP:0001264)1.87313344
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85764224
111Abnormality of serum amino acid levels (HP:0003112)1.85601113
112Abnormality of the renal cortex (HP:0011035)1.84322213
113Abnormal protein glycosylation (HP:0012346)1.83914378
114Abnormal glycosylation (HP:0012345)1.83914378
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83914378
116Abnormal protein N-linked glycosylation (HP:0012347)1.83914378
117Progressive inability to walk (HP:0002505)1.83451196
118Premature graying of hair (HP:0002216)1.83261330
119Horseshoe kidney (HP:0000085)1.82795611
120Cleft eyelid (HP:0000625)1.81960435
121Abnormality of subcutaneous fat tissue (HP:0001001)1.81789048
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81589036
123Short 4th metacarpal (HP:0010044)1.81589036
124Secondary amenorrhea (HP:0000869)1.81294886
125Small hand (HP:0200055)1.81183969
126Shawl scrotum (HP:0000049)1.80660221
127Neoplasm of the oral cavity (HP:0100649)1.80285420
128Abnormality of methionine metabolism (HP:0010901)1.79647308
129Abolished electroretinogram (ERG) (HP:0000550)1.79552019
130Squamous cell carcinoma (HP:0002860)1.79508279
131Premature ovarian failure (HP:0008209)1.79492971
132Cerebral hypomyelination (HP:0006808)1.79089640
133Tracheoesophageal fistula (HP:0002575)1.78837901
134Nephroblastoma (Wilms tumor) (HP:0002667)1.78552369
135Rib fusion (HP:0000902)1.78198634
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.78169842
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78146151
138High pitched voice (HP:0001620)1.77260280
139Increased serum lactate (HP:0002151)1.76557816
140Macrocytic anemia (HP:0001972)1.75889881
141Thrombocytosis (HP:0001894)1.75836395
142Type I transferrin isoform profile (HP:0003642)1.75214776
143Facial hemangioma (HP:0000329)1.74703540
144Combined immunodeficiency (HP:0005387)1.71547558
145Dandy-Walker malformation (HP:0001305)1.71314170
146Embryonal renal neoplasm (HP:0011794)1.69532328
147Increased CSF lactate (HP:0002490)1.68965009
148Methylmalonic acidemia (HP:0002912)1.68896536
149Prominent nose (HP:0000448)1.68546904
150Rectal fistula (HP:0100590)1.67154748
151Rectovaginal fistula (HP:0000143)1.67154748
152Tubular atrophy (HP:0000092)1.66980421
153Acute myeloid leukemia (HP:0004808)1.66916052
154Pallor (HP:0000980)1.66750602
155Hypoproteinemia (HP:0003075)1.65460708
156Gaze-evoked nystagmus (HP:0000640)1.63177068
157Increased serum pyruvate (HP:0003542)1.62937432
158Triphalangeal thumb (HP:0001199)1.62250907
159Severe combined immunodeficiency (HP:0004430)1.62127687
160Abnormality of glycolysis (HP:0004366)1.61932369
161Hypoglycemic coma (HP:0001325)1.61508925
162Prostate neoplasm (HP:0100787)1.60459583
163Molar tooth sign on MRI (HP:0002419)1.59555874
164Abnormality of midbrain morphology (HP:0002418)1.59555874
165Pelvic girdle muscle weakness (HP:0003749)1.58212085
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.57858940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.46280977
2WEE14.40251271
3VRK24.22990708
4CDC73.98259081
5MUSK3.12870416
6EIF2AK13.11483117
7BRSK22.84427182
8NEK22.65787914
9ACVR1B2.63565433
10TTK2.41080227
11SRPK12.38908682
12NEK12.32393945
13TSSK62.16100462
14MKNK12.15597045
15PASK2.14973118
16NUAK12.07532965
17PLK42.01499740
18CDK121.97924176
19PLK11.94709252
20IRAK31.93293358
21TRIM281.89939115
22PLK31.74153454
23PBK1.69932622
24FRK1.69765066
25AURKB1.69515997
26RPS6KA41.65466836
27RPS6KB21.60854669
28ATR1.59848685
29STK31.56074312
30CDK41.54923370
31EPHA21.54543299
32TAF11.54416779
33CDK71.52629532
34STK391.52015315
35FLT31.51510455
36PKN21.51006915
37EIF2AK31.45725356
38STK101.44366683
39BRSK11.42895383
40EEF2K1.39746800
41MKNK21.39171871
42MAP3K81.36333508
43DYRK31.35348291
44VRK11.34541403
45LATS11.34215676
46NME21.24636757
47SCYL21.23160029
48TGFBR11.21016343
49CHEK21.20502832
50CDK61.18408504
51BMPR1B1.18233599
52STK38L1.14416166
53CHEK11.13488961
54AURKA1.10341852
55CCNB11.10293525
56PLK20.99909029
57PAK40.99623197
58TESK20.99312058
59STK40.98800134
60MAP4K20.96494005
61ERBB40.95755991
62NME10.93032326
63ALK0.92467818
64ATM0.92179317
65BCKDK0.89413883
66CDK20.85822269
67PIM10.84715909
68MELK0.84631431
69WNK30.83206626
70WNK40.81612193
71LATS20.78510410
72MAP3K100.77921223
73MAP2K30.75152734
74BRD40.72456586
75MAP3K120.71203991
76ZAK0.70476980
77PDK20.69837253
78STK160.69639261
79STK240.68640023
80OXSR10.67834270
81CSNK2A20.66337584
82CDK80.65812349
83LRRK20.65032305
84CSNK2A10.64337778
85NEK90.63391311
86FGFR10.61331795
87CDK10.60319662
88TAOK20.58660302
89MTOR0.57625599
90TLK10.54538264
91EIF2AK20.54263848
92TNIK0.53065981
93AKT30.46480892
94MET0.46273922
95PNCK0.46104477
96PAK10.43960040
97PRKCI0.43617679
98DAPK10.43571961
99GRK10.43257579
100CSNK1G10.42793134
101MST40.39927912
102MAP3K30.39471431
103ADRBK20.39456650
104CDK90.38546883
105MAP3K40.38274831
106MAP3K50.36439925
107KDR0.35826293
108RPS6KA50.35819324
109INSRR0.35194672
110CSNK1A1L0.34108087
111RAF10.33979156
112CSNK1G30.33786340
113BCR0.32269233
114PDK30.30254977
115PDK40.30254977
116CSNK1E0.29943585
117PINK10.29566486
118ILK0.29506056
119CDK30.29394880
120PAK20.29075350
121TAOK30.28634753
122AKT20.28339786
123TESK10.27720682
124ERBB30.27472659
125BRAF0.27163667
126PRKDC0.26892038
127JAK30.26807334
128CHUK0.26289658
129MAPK140.25313617
130MAP2K70.25313108
131PRKCE0.25025999
132PTK60.24127923
133RPS6KB10.23630542
134AKT10.22931599
135MAPKAPK30.22475009
136PRKACB0.22332027
137MAPK10.20231115
138CLK10.19317521
139PDGFRA0.18612799
140MARK30.18476094

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64197937
2Mismatch repair_Homo sapiens_hsa034304.17717336
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62672810
4* RNA transport_Homo sapiens_hsa030133.18637404
5One carbon pool by folate_Homo sapiens_hsa006703.17038769
6Spliceosome_Homo sapiens_hsa030403.08720684
7Cell cycle_Homo sapiens_hsa041102.95602393
8RNA polymerase_Homo sapiens_hsa030202.88248626
9Base excision repair_Homo sapiens_hsa034102.80434304
10Nucleotide excision repair_Homo sapiens_hsa034202.68553093
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59281144
12Proteasome_Homo sapiens_hsa030502.57797682
13Homologous recombination_Homo sapiens_hsa034402.55712089
14Ribosome_Homo sapiens_hsa030102.52166733
15Sulfur metabolism_Homo sapiens_hsa009202.44146306
16Pyrimidine metabolism_Homo sapiens_hsa002402.24961191
17RNA degradation_Homo sapiens_hsa030182.02651282
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96563246
19Fanconi anemia pathway_Homo sapiens_hsa034601.80576967
20Basal transcription factors_Homo sapiens_hsa030221.71350087
21p53 signaling pathway_Homo sapiens_hsa041151.70649274
22Non-homologous end-joining_Homo sapiens_hsa034501.67431212
23mRNA surveillance pathway_Homo sapiens_hsa030151.66569290
24Selenocompound metabolism_Homo sapiens_hsa004501.48814376
25Biosynthesis of amino acids_Homo sapiens_hsa012301.30968847
26Propanoate metabolism_Homo sapiens_hsa006401.28239112
27Ether lipid metabolism_Homo sapiens_hsa005651.21678524
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.16014285
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.16010720
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12381032
31Vitamin B6 metabolism_Homo sapiens_hsa007501.11654565
32Folate biosynthesis_Homo sapiens_hsa007901.09911918
33Epstein-Barr virus infection_Homo sapiens_hsa051691.09290306
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.08099812
35Steroid biosynthesis_Homo sapiens_hsa001001.07872081
36Purine metabolism_Homo sapiens_hsa002301.07572680
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06926636
38Parkinsons disease_Homo sapiens_hsa050121.06564716
39Herpes simplex infection_Homo sapiens_hsa051680.98245132
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97370510
41Viral carcinogenesis_Homo sapiens_hsa052030.96483593
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92711673
43Antigen processing and presentation_Homo sapiens_hsa046120.91642567
44Oocyte meiosis_Homo sapiens_hsa041140.91161048
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90738162
46Carbon metabolism_Homo sapiens_hsa012000.90423199
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87969508
48Systemic lupus erythematosus_Homo sapiens_hsa053220.87126600
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87091900
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85831382
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85509560
52Protein export_Homo sapiens_hsa030600.85444266
53Oxidative phosphorylation_Homo sapiens_hsa001900.85306550
54Huntingtons disease_Homo sapiens_hsa050160.84785347
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83751235
56Pentose phosphate pathway_Homo sapiens_hsa000300.82278884
57Butanoate metabolism_Homo sapiens_hsa006500.82071061
58Thyroid cancer_Homo sapiens_hsa052160.79757203
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77661905
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75473201
61Small cell lung cancer_Homo sapiens_hsa052220.74256149
62Nitrogen metabolism_Homo sapiens_hsa009100.73092184
63HTLV-I infection_Homo sapiens_hsa051660.72061186
64Legionellosis_Homo sapiens_hsa051340.68703781
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68493465
66MicroRNAs in cancer_Homo sapiens_hsa052060.63892869
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62819995
68Fatty acid biosynthesis_Homo sapiens_hsa000610.59184203
69Peroxisome_Homo sapiens_hsa041460.57935489
70Hippo signaling pathway_Homo sapiens_hsa043900.57885904
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56090957
72Phototransduction_Homo sapiens_hsa047440.55905827
73TGF-beta signaling pathway_Homo sapiens_hsa043500.55485159
74Glutathione metabolism_Homo sapiens_hsa004800.52773266
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50943942
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.49477462
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46809996
78Sulfur relay system_Homo sapiens_hsa041220.46723904
79Galactose metabolism_Homo sapiens_hsa000520.46080942
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45258518
81Alzheimers disease_Homo sapiens_hsa050100.43228189
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.40426886
83Adherens junction_Homo sapiens_hsa045200.38031058
84Olfactory transduction_Homo sapiens_hsa047400.37745747
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37398097
86Bladder cancer_Homo sapiens_hsa052190.37232302
87Fructose and mannose metabolism_Homo sapiens_hsa000510.36673301
88Tryptophan metabolism_Homo sapiens_hsa003800.35942291
89Lysine degradation_Homo sapiens_hsa003100.35457130
90Hepatitis B_Homo sapiens_hsa051610.35356634
91N-Glycan biosynthesis_Homo sapiens_hsa005100.34450071
92Basal cell carcinoma_Homo sapiens_hsa052170.33281892
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32092121
94Pyruvate metabolism_Homo sapiens_hsa006200.31860985
95Fatty acid metabolism_Homo sapiens_hsa012120.31544506
96Colorectal cancer_Homo sapiens_hsa052100.31398452
97Apoptosis_Homo sapiens_hsa042100.31208103
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30676238
99Chronic myeloid leukemia_Homo sapiens_hsa052200.29310972
100Measles_Homo sapiens_hsa051620.29173216
101Taste transduction_Homo sapiens_hsa047420.26815813
102Fatty acid elongation_Homo sapiens_hsa000620.25069023
103HIF-1 signaling pathway_Homo sapiens_hsa040660.24706299
104Prostate cancer_Homo sapiens_hsa052150.22989798
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20553622
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20479644
107mTOR signaling pathway_Homo sapiens_hsa041500.20450405
108Influenza A_Homo sapiens_hsa051640.19235295
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19027923
110Metabolic pathways_Homo sapiens_hsa011000.18876279
111Pathways in cancer_Homo sapiens_hsa052000.18510078
112Arginine and proline metabolism_Homo sapiens_hsa003300.18491854
113FoxO signaling pathway_Homo sapiens_hsa040680.18073672
114Notch signaling pathway_Homo sapiens_hsa043300.18054834
115Caffeine metabolism_Homo sapiens_hsa002320.17276853
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.16541701
117Linoleic acid metabolism_Homo sapiens_hsa005910.16369123
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15942868
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15593480
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15589347
121GABAergic synapse_Homo sapiens_hsa047270.15351732
122Glucagon signaling pathway_Homo sapiens_hsa049220.15146219
123Wnt signaling pathway_Homo sapiens_hsa043100.11978502
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11591587
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11241700
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.11041695
127Circadian rhythm_Homo sapiens_hsa047100.10973279
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10500710
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09544425
130Acute myeloid leukemia_Homo sapiens_hsa052210.09492650
131Melanoma_Homo sapiens_hsa052180.08497037
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.08418189
133Hedgehog signaling pathway_Homo sapiens_hsa043400.08289630
134Shigellosis_Homo sapiens_hsa051310.08280691
135Retinol metabolism_Homo sapiens_hsa008300.04968025
136Alcoholism_Homo sapiens_hsa050340.04127091
137Amphetamine addiction_Homo sapiens_hsa050310.03931418
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.03905697

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »