SECISBP2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.77186381
2central nervous system myelination (GO:0022010)8.77186381
3fatty acid elongation (GO:0030497)7.26638317
4ensheathment of neurons (GO:0007272)6.32356808
5axon ensheathment (GO:0008366)6.32356808
6myelination (GO:0042552)6.17103042
7long-chain fatty acid biosynthetic process (GO:0042759)4.97675489
8myelin maintenance (GO:0043217)4.78211830
9cholesterol biosynthetic process (GO:0006695)4.77606261
10negative regulation of neurotransmitter secretion (GO:0046929)4.57717190
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.50173144
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.45625799
13negative regulation of neurotransmitter transport (GO:0051589)4.18562348
14sterol biosynthetic process (GO:0016126)4.17707606
15myelination in peripheral nervous system (GO:0022011)4.11684505
16peripheral nervous system axon ensheathment (GO:0032292)4.11684505
17long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.09120145
18response to methylmercury (GO:0051597)4.05941002
19synaptic vesicle maturation (GO:0016188)4.02381412
20L-amino acid import (GO:0043092)4.01889880
21fatty-acyl-CoA biosynthetic process (GO:0046949)4.01821549
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81282861
23peptidyl-tyrosine autophosphorylation (GO:0038083)3.79523884
24import into cell (GO:0098657)3.73068302
25response to lipoprotein particle (GO:0055094)3.70564870
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70465190
27regulation of collateral sprouting (GO:0048670)3.68534642
28glycerophospholipid catabolic process (GO:0046475)3.67520669
29glutamate secretion (GO:0014047)3.66357826
30asymmetric protein localization (GO:0008105)3.64437381
31negative regulation of protein localization to cell surface (GO:2000009)3.62346489
32photoreceptor cell differentiation (GO:0046530)3.62011930
33eye photoreceptor cell differentiation (GO:0001754)3.62011930
34apical protein localization (GO:0045176)3.62007025
35regulation of synaptic vesicle exocytosis (GO:2000300)3.61638242
36fatty-acyl-CoA metabolic process (GO:0035337)3.61122012
37creatine metabolic process (GO:0006600)3.58829428
38oligodendrocyte differentiation (GO:0048709)3.57616486
39isoprenoid biosynthetic process (GO:0008299)3.53792099
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.48016603
41cellular potassium ion homeostasis (GO:0030007)3.47397601
42establishment of mitochondrion localization (GO:0051654)3.44595970
43amyloid precursor protein metabolic process (GO:0042982)3.39903594
44negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.39164084
45astrocyte development (GO:0014002)3.36690966
46nerve growth factor signaling pathway (GO:0038180)3.34247917
47locomotory exploration behavior (GO:0035641)3.33842113
48synaptic vesicle exocytosis (GO:0016079)3.29870772
49sodium ion export (GO:0071436)3.29765191
50acyl-CoA biosynthetic process (GO:0071616)3.27936106
51thioester biosynthetic process (GO:0035384)3.27936106
52presynaptic membrane organization (GO:0097090)3.21298154
53neuronal action potential propagation (GO:0019227)3.19428159
54virion attachment to host cell (GO:0019062)3.18239697
55adhesion of symbiont to host cell (GO:0044650)3.18239697
56very long-chain fatty acid metabolic process (GO:0000038)3.17597880
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15408136
58presynaptic membrane assembly (GO:0097105)3.14475368
59regulation of synaptic vesicle transport (GO:1902803)3.13373899
60substantia nigra development (GO:0021762)3.13360263
61regulation of lipoprotein metabolic process (GO:0050746)3.10825070
62cerebellar Purkinje cell differentiation (GO:0021702)3.09519977
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09165644
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06981908
65regulation of ARF protein signal transduction (GO:0032012)3.04161059
66vocalization behavior (GO:0071625)3.02073043
67negative regulation of axonogenesis (GO:0050771)2.91287558
68response to redox state (GO:0051775)2.91233244
69amino acid import (GO:0043090)2.90101579
70protein localization to endosome (GO:0036010)2.89887593
71peripheral nervous system development (GO:0007422)2.89816396
72regulation of neuronal synaptic plasticity (GO:0048168)2.88625243
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.87839750
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.84734206
75glutamate receptor signaling pathway (GO:0007215)2.83306721
76membrane tubulation (GO:0097320)2.83076688
77phospholipid translocation (GO:0045332)2.79269579
78lipid translocation (GO:0034204)2.79269579
79transmission of nerve impulse (GO:0019226)2.77396589
80synaptic transmission, glutamatergic (GO:0035249)2.76980576
81establishment of nucleus localization (GO:0040023)2.74699147
82exploration behavior (GO:0035640)2.74481645
83cellular sodium ion homeostasis (GO:0006883)2.72914811
84magnesium ion transport (GO:0015693)2.72371681
85neurotransmitter secretion (GO:0007269)2.67650180
86glycosylceramide metabolic process (GO:0006677)2.67340315
87protein palmitoylation (GO:0018345)2.66560956
88neuron remodeling (GO:0016322)2.65796815
89axonal fasciculation (GO:0007413)2.64485567
90neurotransmitter-gated ion channel clustering (GO:0072578)2.63412436
91cell communication by electrical coupling (GO:0010644)2.62159201
92negative regulation of axon extension (GO:0030517)2.61121826
93cerebral cortex radially oriented cell migration (GO:0021799)2.60939602
94potassium ion import (GO:0010107)2.59183633
95dendritic spine morphogenesis (GO:0060997)2.58337117
96potassium ion homeostasis (GO:0055075)2.57570964
97neuronal ion channel clustering (GO:0045161)2.57403964
98neuron cell-cell adhesion (GO:0007158)2.55802287
99amyloid precursor protein catabolic process (GO:0042987)2.55119564
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.54536581
101positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54492787
102Rap protein signal transduction (GO:0032486)2.53651670
103adult walking behavior (GO:0007628)2.51728751
104Leydig cell differentiation (GO:0033327)2.51710470
105triglyceride biosynthetic process (GO:0019432)2.51666436
106peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51582425
107regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50858331
108postsynaptic membrane organization (GO:0001941)2.50750714
109regulation of Rap GTPase activity (GO:0032317)2.50623080
110positive regulation of neurological system process (GO:0031646)2.50392426
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.50196012
112axon development (GO:0061564)2.48061358
113regulation of glutamate receptor signaling pathway (GO:1900449)2.47608934
114neuron-neuron synaptic transmission (GO:0007270)2.46824000
115negative regulation of inclusion body assembly (GO:0090084)2.46286636
116adhesion of symbiont to host (GO:0044406)2.46274179
117cellular response to epinephrine stimulus (GO:0071872)2.45780630
118positive regulation of Rap GTPase activity (GO:0032854)2.45231089
119gamma-aminobutyric acid transport (GO:0015812)2.44850992
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.44156357
121macroautophagy (GO:0016236)2.44028716
122detection of temperature stimulus involved in sensory perception (GO:0050961)2.43936821
123detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43936821
124regulation of neurotransmitter secretion (GO:0046928)2.43845931
125nucleus localization (GO:0051647)2.42866614
126Golgi to endosome transport (GO:0006895)2.41219803
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41040280
128neutral lipid biosynthetic process (GO:0046460)2.39756222
129acylglycerol biosynthetic process (GO:0046463)2.39756222
130cerebellar granule cell differentiation (GO:0021707)2.39689160
131regulation of voltage-gated calcium channel activity (GO:1901385)2.38978269
132neurotransmitter uptake (GO:0001504)2.37025803
133cilium or flagellum-dependent cell motility (GO:0001539)2.36851915
134regulation of cell communication by electrical coupling (GO:0010649)2.36570494
135regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36421129
136membrane depolarization during action potential (GO:0086010)2.35538769
137cholesterol metabolic process (GO:0008203)2.35416239
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35373520
139limb bud formation (GO:0060174)2.34785438
140vesicle transport along microtubule (GO:0047496)2.33960318
141long-term memory (GO:0007616)2.33447909
142positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33228380
143membrane assembly (GO:0071709)2.33059203
144negative regulation of dendrite morphogenesis (GO:0050774)2.31149449
145cell differentiation in hindbrain (GO:0021533)2.31065306
146regulation of synaptic plasticity (GO:0048167)2.29423267
147negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29009887
148activation of protein kinase A activity (GO:0034199)2.27933303
149cell communication involved in cardiac conduction (GO:0086065)2.26997661
150cellular response to nerve growth factor stimulus (GO:1990090)2.26989856
151response to nerve growth factor (GO:1990089)2.26989856
152regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.26971290
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26819838
154neuromuscular process controlling balance (GO:0050885)2.26804884
155layer formation in cerebral cortex (GO:0021819)2.25284808
156long-term synaptic potentiation (GO:0060291)2.25165675
157clathrin coat assembly (GO:0048268)2.25006268
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.24358125
159acidic amino acid transport (GO:0015800)2.24175512
160positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.24134423
161cellular response to monoamine stimulus (GO:0071868)2.23831933
162cellular response to catecholamine stimulus (GO:0071870)2.23831933
163regulation of dendritic spine development (GO:0060998)2.23830998
164iron coordination entity transport (GO:1901678)2.19978147
165membrane protein ectodomain proteolysis (GO:0006509)2.19746030
166thioester metabolic process (GO:0035383)2.19152802
167acyl-CoA metabolic process (GO:0006637)2.19152802
168dendrite morphogenesis (GO:0048813)2.18648924
169neuron recognition (GO:0008038)2.17481912
170leukocyte migration involved in inflammatory response (GO:0002523)2.16729161
171glial cell differentiation (GO:0010001)2.15351314
172positive regulation of actin filament depolymerization (GO:0030836)2.15345247
173Golgi to plasma membrane protein transport (GO:0043001)2.12585646
174semaphorin-plexin signaling pathway (GO:0071526)2.12469624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.94289448
2* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.34343364
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28231985
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11952053
5CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99639198
6JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95645768
7MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95157978
8AR_21572438_ChIP-Seq_LNCaP_Human1.93232966
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90687932
10TAF15_26573619_Chip-Seq_HEK293_Human1.89989671
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89572578
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89572578
13* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88607968
14EZH2_22144423_ChIP-Seq_EOC_Human1.88580293
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87400925
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82438825
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79071752
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78392553
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74511207
20DROSHA_22980978_ChIP-Seq_HELA_Human1.73364041
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.64665756
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.63095175
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58852725
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.58210324
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55479672
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.55261245
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53512681
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51177109
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49297454
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.48767039
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47109906
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46921425
33* ER_23166858_ChIP-Seq_MCF-7_Human1.45290479
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41613791
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41613791
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39879661
37* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39007384
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38230082
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.37277686
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36222968
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.35006503
42AHR_22903824_ChIP-Seq_MCF-7_Human1.32653638
43YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32304264
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.30683728
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30456480
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29691784
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.26881657
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.26436338
49STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25465550
50TP53_16413492_ChIP-PET_HCT116_Human1.25272964
51* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25167771
52P300_19829295_ChIP-Seq_ESCs_Human1.25027486
53STAT3_23295773_ChIP-Seq_U87_Human1.24156731
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24094880
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23917285
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23260310
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20684640
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.19442601
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19021030
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18676975
61* RARB_27405468_Chip-Seq_BRAIN_Mouse1.16328745
62AR_19668381_ChIP-Seq_PC3_Human1.15733916
63SMAD4_21799915_ChIP-Seq_A2780_Human1.15711352
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15345381
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15282106
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14963411
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13904736
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.11685193
69AR_25329375_ChIP-Seq_VCAP_Human1.11268813
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07978671
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07700797
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.06081798
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06038800
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03676367
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03430812
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03151254
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.02635746
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02601106
79KDM2B_26808549_Chip-Seq_REH_Human1.02451998
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01307305
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01307305
82* TCF4_23295773_ChIP-Seq_U87_Human1.00789784
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.00272299
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99674159
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99274720
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99009852
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98789304
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98658822
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.98283773
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97783845
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.97430151
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96928171
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96880335
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96726493
95* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96370693
96VDR_22108803_ChIP-Seq_LS180_Human0.95808569
97TP53_18474530_ChIP-ChIP_U2OS_Human0.95745162
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95693902
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94990814
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.94806943
101* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94417415
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94086849
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.94035789
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93869272
105REST_21632747_ChIP-Seq_MESCs_Mouse0.93571249
106IGF1R_20145208_ChIP-Seq_DFB_Human0.93385127
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.92921266
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92900043
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.91038592
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90894123
111CMYC_18555785_Chip-Seq_ESCs_Mouse0.90282321
112FUS_26573619_Chip-Seq_HEK293_Human0.88869697
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88760810
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.88038106
115RUNX2_22187159_ChIP-Seq_PCA_Human0.87935178
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.87734699
117RXR_22108803_ChIP-Seq_LS180_Human0.87396363
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87074228
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86517955
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86494005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.60711968
2MP0003690_abnormal_glial_cell3.58721213
3MP0003950_abnormal_plasma_membrane3.22571538
4MP0004270_analgesia3.20176842
5MP0000569_abnormal_digit_pigmentation3.10446361
6MP0003880_abnormal_central_pattern2.95828638
7MP0003329_amyloid_beta_deposits2.91253762
8MP0004885_abnormal_endolymph2.66091445
9MP0003634_abnormal_glial_cell2.56252591
10MP0003136_yellow_coat_color2.53819763
11MP0004859_abnormal_synaptic_plasticity2.44767051
12MP0005171_absent_coat_pigmentation2.41483398
13MP0002272_abnormal_nervous_system2.40233915
14MP0004742_abnormal_vestibular_system2.39760236
15MP0001486_abnormal_startle_reflex2.22664240
16MP0000778_abnormal_nervous_system2.04083386
17MP0003632_abnormal_nervous_system2.02920911
18MP0002064_seizures2.02480259
19MP0001984_abnormal_olfaction1.99508901
20MP0008438_abnormal_cutaneous_collagen1.98709208
21MP0010678_abnormal_skin_adnexa1.91703022
22MP0005409_darkened_coat_color1.86854089
23MP0001485_abnormal_pinna_reflex1.81912815
24MP0000604_amyloidosis1.81073611
25MP0001905_abnormal_dopamine_level1.76478528
26MP0002229_neurodegeneration1.74304755
27MP0003635_abnormal_synaptic_transmissio1.72589098
28MP0002734_abnormal_mechanical_nocicepti1.71615765
29MP0001529_abnormal_vocalization1.64434314
30MP0009046_muscle_twitch1.62663519
31MP0004272_abnormal_basement_membrane1.62574363
32MP0003631_nervous_system_phenotype1.59159211
33MP0009745_abnormal_behavioral_response1.57641983
34MP0000462_abnormal_digestive_system1.56608535
35MP0004130_abnormal_muscle_cell1.50063209
36MP0000383_abnormal_hair_follicle1.49211732
37MP0004381_abnormal_hair_follicle1.47628082
38MP0004142_abnormal_muscle_tone1.45926686
39MP0003633_abnormal_nervous_system1.45856082
40MP0002909_abnormal_adrenal_gland1.41437103
41MP0003879_abnormal_hair_cell1.40082728
42MP0005623_abnormal_meninges_morphology1.39767497
43MP0003787_abnormal_imprinting1.39145281
44MP0001661_extended_life_span1.39123593
45MP0001177_atelectasis1.34525847
46MP0005451_abnormal_body_composition1.31826967
47MP0008569_lethality_at_weaning1.31420804
48MP0000747_muscle_weakness1.31350155
49MP0002063_abnormal_learning/memory/cond1.29788797
50MP0001299_abnormal_eye_distance/1.29681354
51MP0001968_abnormal_touch/_nociception1.28240365
52MP0005423_abnormal_somatic_nervous1.28144370
53MP0005551_abnormal_eye_electrophysiolog1.27209935
54MP0002882_abnormal_neuron_morphology1.26790884
55MP0002572_abnormal_emotion/affect_behav1.26595652
56MP0001440_abnormal_grooming_behavior1.26073224
57MP0004134_abnormal_chest_morphology1.25392289
58MP0001502_abnormal_circadian_rhythm1.23237603
59MP0002067_abnormal_sensory_capabilities1.22503862
60MP0003091_abnormal_cell_migration1.22188442
61MP0006276_abnormal_autonomic_nervous1.21364442
62MP0000955_abnormal_spinal_cord1.21188956
63MP0005058_abnormal_lysosome_morphology1.17867923
64MP0005646_abnormal_pituitary_gland1.14323681
65MP0002295_abnormal_pulmonary_circulatio1.13810788
66MP0009780_abnormal_chondrocyte_physiolo1.12843074
67MP0002638_abnormal_pupillary_reflex1.12580586
68MP0002733_abnormal_thermal_nociception1.12051632
69MP0002066_abnormal_motor_capabilities/c1.11770901
70MP0003195_calcinosis1.09968576
71MP0005386_behavior/neurological_phenoty1.08355216
72MP0004924_abnormal_behavior1.08355216
73MP0001970_abnormal_pain_threshold1.08351278
74MP0000647_abnormal_sebaceous_gland1.05275476
75MP0003183_abnormal_peptide_metabolism1.03996913
76MP0001851_eye_inflammation1.03113149
77MP0004147_increased_porphyrin_level1.02076806
78MP0004185_abnormal_adipocyte_glucose1.01691730
79MP0001963_abnormal_hearing_physiology1.00039961
80MP0003045_fibrosis0.98784053
81MP0010386_abnormal_urinary_bladder0.98623572
82MP0005410_abnormal_fertilization0.98493959
83MP0008260_abnormal_autophagy0.97754829
84MP0002090_abnormal_vision0.96827422
85MP0005408_hypopigmentation0.94834254
86MP0003122_maternal_imprinting0.94829020
87MP0005167_abnormal_blood-brain_barrier0.94231067
88MP0001879_abnormal_lymphatic_vessel0.92634944
89MP0010368_abnormal_lymphatic_system0.91364161
90MP0001346_abnormal_lacrimal_gland0.91326836
91MP0002752_abnormal_somatic_nervous0.91011911
92MP0005195_abnormal_posterior_eye0.88426947
93MP0000003_abnormal_adipose_tissue0.85947582
94MP0002184_abnormal_innervation0.85387988
95MP0002118_abnormal_lipid_homeostasis0.83777734
96MP0004043_abnormal_pH_regulation0.83633198
97MP0005275_abnormal_skin_tensile0.82615472
98MP0005388_respiratory_system_phenotype0.81058795
99MP0002133_abnormal_respiratory_system0.81058795
100MP0000579_abnormal_nail_morphology0.80233705
101MP0002971_abnormal_brown_adipose0.79910760
102MP0002822_catalepsy0.78565204
103MP0003806_abnormal_nucleotide_metabolis0.77402854
104MP0001501_abnormal_sleep_pattern0.76698315
105MP0003075_altered_response_to0.74270012
106MP0004484_altered_response_of0.73903840
107MP0002009_preneoplasia0.73901736
108MP0004858_abnormal_nervous_system0.72009905
109MP0002152_abnormal_brain_morphology0.71407546
110MP0004145_abnormal_muscle_electrophysio0.71334889
111MP0001958_emphysema0.71156697
112MP0005595_abnormal_vascular_smooth0.70433546
113MP0005187_abnormal_penis_morphology0.69754777
114MP0004036_abnormal_muscle_relaxation0.69161089
115MP0002735_abnormal_chemical_nociception0.68996941
116MP0005083_abnormal_biliary_tract0.68868302
117MP0005248_abnormal_Harderian_gland0.68327688
118MP0005503_abnormal_tendon_morphology0.67215168
119MP0005375_adipose_tissue_phenotype0.66095288
120MP0002168_other_aberrant_phenotype0.66016672
121MP0002557_abnormal_social/conspecific_i0.65922072
122MP0009384_cardiac_valve_regurgitation0.65552614
123MP0001348_abnormal_lacrimal_gland0.63214080
124MP0002736_abnormal_nociception_after0.62798904
125MP0003937_abnormal_limbs/digits/tail_de0.62383193
126MP0000639_abnormal_adrenal_gland0.62045448
127MP0004085_abnormal_heartbeat0.61902248
128MP0000013_abnormal_adipose_tissue0.61532532
129MP0004215_abnormal_myocardial_fiber0.61452652
130MP0008874_decreased_physiological_sensi0.60622513
131MP0004811_abnormal_neuron_physiology0.59760480
132MP0002108_abnormal_muscle_morphology0.59148096
133MP0000762_abnormal_tongue_morphology0.58826000
134MP0004084_abnormal_cardiac_muscle0.57577624
135MP0000534_abnormal_ureter_morphology0.56976702
136MP0003868_abnormal_feces_composition0.55126521
137MP0005666_abnormal_adipose_tissue0.55078891

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)6.41554454
2Insidious onset (HP:0003587)6.41554454
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.28080925
4Degeneration of the lateral corticospinal tracts (HP:0002314)6.28080925
5Neurofibrillary tangles (HP:0002185)6.06022356
6Segmental peripheral demyelination/remyelination (HP:0003481)5.28027757
7Peripheral hypomyelination (HP:0007182)5.22148740
8Onion bulb formation (HP:0003383)5.09807220
9Abnormality of the corticospinal tract (HP:0002492)4.94842227
10Ulnar claw (HP:0001178)4.66765534
11Cerebral inclusion bodies (HP:0100314)4.57427913
12Sensory axonal neuropathy (HP:0003390)4.52204960
13Action tremor (HP:0002345)4.33425930
14Focal motor seizures (HP:0011153)4.14745854
15Febrile seizures (HP:0002373)4.13506334
16Parakeratosis (HP:0001036)4.08077004
17Supranuclear gaze palsy (HP:0000605)3.78302026
18Focal seizures (HP:0007359)3.70034968
19Intention tremor (HP:0002080)3.49013818
20Spastic gait (HP:0002064)3.42470630
21Abnormal auditory evoked potentials (HP:0006958)3.20965081
22Hammertoe (HP:0001765)3.08497468
23Dysmetria (HP:0001310)3.04564273
24Papillary thyroid carcinoma (HP:0002895)2.96492500
25Steppage gait (HP:0003376)2.95809879
26Progressive cerebellar ataxia (HP:0002073)2.91823943
27Decreased motor nerve conduction velocity (HP:0003431)2.91795786
28Akinesia (HP:0002304)2.88827944
29Peripheral demyelination (HP:0011096)2.88622854
30Foot dorsiflexor weakness (HP:0009027)2.83358470
31Scanning speech (HP:0002168)2.82426766
32Epileptic encephalopathy (HP:0200134)2.79403898
33Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.78358290
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74989699
35Ankle clonus (HP:0011448)2.74225965
36Alacrima (HP:0000522)2.73301232
37Papilledema (HP:0001085)2.72398986
38Slow saccadic eye movements (HP:0000514)2.72232973
39Hyperventilation (HP:0002883)2.70606034
40Myokymia (HP:0002411)2.63418511
41Arterial tortuosity (HP:0005116)2.59521554
42Cerebral hemorrhage (HP:0001342)2.54720507
43Abnormality of the foot musculature (HP:0001436)2.52013847
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48992874
45Premature skin wrinkling (HP:0100678)2.47070529
46Overgrowth (HP:0001548)2.46017347
47Clumsiness (HP:0002312)2.44644388
48Diplopia (HP:0000651)2.44049610
49Abnormality of binocular vision (HP:0011514)2.44049610
50Obstructive sleep apnea (HP:0002870)2.43860683
51Vascular tortuosity (HP:0004948)2.42754195
52Postural tremor (HP:0002174)2.41174932
53Bundle branch block (HP:0011710)2.39844606
54Genetic anticipation (HP:0003743)2.36152672
55Infantile muscular hypotonia (HP:0008947)2.34823145
56Cerebral hypomyelination (HP:0006808)2.34581598
57Stridor (HP:0010307)2.34537362
58Hypoplasia of the iris (HP:0007676)2.34240701
59Impaired proprioception (HP:0010831)2.32931876
60Retinal dysplasia (HP:0007973)2.32032531
61Absence seizures (HP:0002121)2.31973617
62Absent speech (HP:0001344)2.30959253
63Postural instability (HP:0002172)2.29598716
64Drooling (HP:0002307)2.27978336
65Spastic paraparesis (HP:0002313)2.26429441
66Truncal ataxia (HP:0002078)2.24655760
67Congenital ichthyosiform erythroderma (HP:0007431)2.23884033
68Distal sensory impairment (HP:0002936)2.23797418
69Dialeptic seizures (HP:0011146)2.23131309
70Axonal loss (HP:0003447)2.22866574
71Anteriorly placed anus (HP:0001545)2.22473411
72Abnormal eating behavior (HP:0100738)2.21704092
73Hypomagnesemia (HP:0002917)2.21343643
74Aplasia involving bones of the upper limbs (HP:0009823)2.20946190
75Aplasia of the phalanges of the hand (HP:0009802)2.20946190
76Aplasia involving bones of the extremities (HP:0009825)2.20946190
77Hemiplegia (HP:0002301)2.20786888
78Lower limb muscle weakness (HP:0007340)2.20412751
79Coronal craniosynostosis (HP:0004440)2.19620129
80Autoamputation (HP:0001218)2.17667749
81Pheochromocytoma (HP:0002666)2.17296463
82Increased serum pyruvate (HP:0003542)2.16174288
83Abnormality of glycolysis (HP:0004366)2.16174288
84Dysmetric saccades (HP:0000641)2.15969670
85Impaired vibration sensation in the lower limbs (HP:0002166)2.15892199
86Gaze-evoked nystagmus (HP:0000640)2.15311934
87Increased circulating renin level (HP:0000848)2.12825086
88Excessive salivation (HP:0003781)2.11921762
89Increased CSF protein (HP:0002922)2.10881479
90Thickened helices (HP:0000391)2.08663627
91Abnormality of the ischium (HP:0003174)2.08647569
92Spastic tetraparesis (HP:0001285)2.08608195
93Decreased lacrimation (HP:0000633)2.07078894
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05528986
95Generalized tonic-clonic seizures (HP:0002069)2.02024801
96Leukodystrophy (HP:0002415)1.99907864
97Metabolic alkalosis (HP:0200114)1.93943409
98Urinary urgency (HP:0000012)1.92663233
99Clonus (HP:0002169)1.91062997
100Impaired vibratory sensation (HP:0002495)1.88580995
101Megalencephaly (HP:0001355)1.88528371
102Hypoplastic pelvis (HP:0008839)1.88010360
103Broad-based gait (HP:0002136)1.87570123
104Hyperkalemia (HP:0002153)1.86636004
105Partial agenesis of the corpus callosum (HP:0001338)1.86579204
106Spastic paraplegia (HP:0001258)1.85281542
107Bronchomalacia (HP:0002780)1.85144798
108Difficulty running (HP:0009046)1.82858524
109Hyporeflexia of lower limbs (HP:0002600)1.82557304
110Esophageal atresia (HP:0002032)1.82161707
111Relative macrocephaly (HP:0004482)1.82075270
112Hypokalemic alkalosis (HP:0001949)1.80948891
113Morphological abnormality of the inner ear (HP:0011390)1.80410063
114Neoplasm of the heart (HP:0100544)1.79970296
115White forelock (HP:0002211)1.77918493
116Aortic aneurysm (HP:0004942)1.77624469
117Widely spaced teeth (HP:0000687)1.76773760
118Morphological abnormality of the pyramidal tract (HP:0002062)1.76714558
119Paraplegia (HP:0010550)1.76496565
120Paraparesis (HP:0002385)1.76480977
121Hyperaldosteronism (HP:0000859)1.76217222
122Poor eye contact (HP:0000817)1.74875987
123Hypophosphatemic rickets (HP:0004912)1.74866650
124Mild short stature (HP:0003502)1.73897573
125Neuroendocrine neoplasm (HP:0100634)1.73660431
126Humeroradial synostosis (HP:0003041)1.73436609
127Synostosis involving the elbow (HP:0003938)1.73436609
128Hepatosplenomegaly (HP:0001433)1.73073080
129Urinary bladder sphincter dysfunction (HP:0002839)1.71427426
130Cupped ear (HP:0000378)1.71154740
131Atonic seizures (HP:0010819)1.70975081
132Abnormal ciliary motility (HP:0012262)1.70489025
133Abnormality of the lower motor neuron (HP:0002366)1.69882180
134Abnormal pupillary function (HP:0007686)1.69539070
135Dysdiadochokinesis (HP:0002075)1.67811911
136Buphthalmos (HP:0000557)1.67105976
137Epileptiform EEG discharges (HP:0011182)1.66853764
138Amyotrophic lateral sclerosis (HP:0007354)1.66503183
139Generalized myoclonic seizures (HP:0002123)1.66384047
140Blue irides (HP:0000635)1.65434592
141Urinary incontinence (HP:0000020)1.65353123
142Sleep apnea (HP:0010535)1.64369666
143Premature rupture of membranes (HP:0001788)1.63387954
144Turricephaly (HP:0000262)1.63126172
145Hyperlipoproteinemia (HP:0010980)1.63124547
146Patchy hypopigmentation of hair (HP:0011365)1.62928637
147Loss of speech (HP:0002371)1.62303709
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.61343817
149Absent/shortened dynein arms (HP:0200106)1.61343817
150Aortic dissection (HP:0002647)1.61303651
151Bell-shaped thorax (HP:0001591)1.61035806
152Impaired social interactions (HP:0000735)1.60391373
153Abnormal social behavior (HP:0012433)1.60391373
154Anomalous pulmonary venous return (HP:0010772)1.60366879
155Generalized hypopigmentation of hair (HP:0011358)1.59183340
156Abnormality of the periventricular white matter (HP:0002518)1.58747095
157Macroorchidism (HP:0000053)1.58104068
158Rhinitis (HP:0012384)1.57772110
159Hemiparesis (HP:0001269)1.57465367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.33319953
2EPHB14.47260574
3OXSR14.16706566
4WNK42.60137388
5PKN12.45946057
6FGFR22.44848078
7AKT32.31044900
8TNIK2.30148341
9BCR2.26710892
10MAPKAPK52.08098291
11SGK22.03383435
12WNK12.02950826
13MET2.00827395
14DAPK21.95586768
15NTRK11.86084421
16PBK1.81625651
17UHMK11.66401884
18RIPK11.65009724
19EPHA41.62449066
20SGK31.60588062
21LATS21.59710905
22CDK191.53372328
23ICK1.52776538
24PRPF4B1.51844965
25TYRO31.43460508
26ROCK21.39726676
27CSNK1A1L1.39250313
28CAMKK11.37633051
29SGK4941.37631042
30SGK2231.37631042
31PAK61.37462656
32PNCK1.35163181
33LIMK11.33197024
34STK381.31148092
35CAMK1G1.29640216
36FRK1.28813999
37NEK61.28511206
38FGR1.27443981
39IRAK21.27217972
40CSNK1G31.26693920
41LATS11.24340298
42PDGFRA1.23984044
43CAMKK21.22997535
44CAMK2B1.12847756
45CSNK1G21.12820686
46MST41.11935406
47PAK31.10669434
48CSNK1G11.07912532
49MARK11.06911815
50MARK21.02777446
51DYRK1A1.01150274
52CLK11.01020484
53NEK91.00946813
54CASK1.00049596
55FGFR30.99653563
56JAK10.99604092
57CAMK2D0.97786427
58IRAK10.97057159
59PRKCQ0.94638341
60PINK10.93842087
61FER0.92696603
62CDK50.92292439
63STK38L0.91184186
64BRD40.90993428
65MAP2K40.89150142
66CAMK10.88455071
67PRKD10.86491969
68SIK20.86392519
69KSR20.86221367
70CDK120.84820471
71MAP3K20.79771191
72PDPK10.78451222
73CAMK2A0.74494774
74MAPK130.73406115
75CAMK1D0.72018679
76PDGFRB0.71554868
77FYN0.71257594
78MAP3K120.70184984
79KSR10.69970311
80BMPR20.69785730
81MAP3K70.69206301
82CAMK2G0.68937909
83CDK140.66664167
84PRKCE0.66591390
85RET0.65330519
86DDR20.64196955
87CAMK40.64170462
88MAP3K130.64052994
89MAPK120.63654979
90DMPK0.62788592
91ERBB30.62582567
92ERBB40.61520692
93MAP3K90.61423173
94ERBB20.60851525
95RPS6KA30.58707746
96PHKG20.58324094
97PHKG10.58324094
98FES0.58302993
99GSK3A0.57869984
100MAPK70.56102855
101NLK0.55949174
102TIE10.55527401
103CDK150.54395518
104NTRK20.51327336
105PIK3CA0.51233334
106PRKCG0.51228209
107RIPK40.50776654
108MAPK150.50497927
109PRKCH0.49796888
110CDK180.49786804
111YES10.48974550
112TRPM70.48621812
113ROCK10.48518436
114MAP3K40.48340234
115STK110.48198144
116PDK10.48074362
117GRK50.47672043
118DYRK20.47581305
119PRKCZ0.47181456
120PRKD30.46252505
121TESK20.45133288
122PTK2B0.44931986
123BMX0.44802591
124CDK11A0.44462503
125CSNK1D0.43054135
126NTRK30.41109695
127PRKG10.40983289
128PLK20.40463273
129INSR0.38835389
130SIK10.38273138
131CSNK1A10.37422910
132PRKACB0.36960915
133ARAF0.35823255
134SGK10.35619189
135EPHA30.34361645
136PTK20.33967295
137MINK10.33840734
138BMPR1B0.32668024
139CSK0.31525502
140MAPK100.31193752
141SRC0.31013256

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.82857442
2Steroid biosynthesis_Homo sapiens_hsa001004.44676152
3Fatty acid elongation_Homo sapiens_hsa000623.72189903
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48792588
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75094793
6Ether lipid metabolism_Homo sapiens_hsa005652.42896316
7Butanoate metabolism_Homo sapiens_hsa006501.76748645
8Axon guidance_Homo sapiens_hsa043601.72920408
9Sulfur metabolism_Homo sapiens_hsa009201.61087404
10Nitrogen metabolism_Homo sapiens_hsa009101.60789199
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58833385
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58369282
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52912386
14Insulin secretion_Homo sapiens_hsa049111.51383393
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49719078
16Fatty acid biosynthesis_Homo sapiens_hsa000611.43289268
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40042965
18Fatty acid metabolism_Homo sapiens_hsa012121.34590763
19Histidine metabolism_Homo sapiens_hsa003401.31167581
20Sphingolipid metabolism_Homo sapiens_hsa006001.26927636
21Glutamatergic synapse_Homo sapiens_hsa047241.22891024
22Circadian rhythm_Homo sapiens_hsa047101.21720955
23Estrogen signaling pathway_Homo sapiens_hsa049151.19451042
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18005606
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17843761
26GABAergic synapse_Homo sapiens_hsa047271.16879269
27Renal cell carcinoma_Homo sapiens_hsa052111.15495957
28Calcium signaling pathway_Homo sapiens_hsa040201.09604236
29Taste transduction_Homo sapiens_hsa047421.08039620
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07701343
31Long-term depression_Homo sapiens_hsa047301.02906629
32Serotonergic synapse_Homo sapiens_hsa047261.02171360
33Glioma_Homo sapiens_hsa052141.01975846
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00423616
35Inositol phosphate metabolism_Homo sapiens_hsa005620.99831109
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99188999
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99148215
38Tight junction_Homo sapiens_hsa045300.98545411
39Linoleic acid metabolism_Homo sapiens_hsa005910.97113080
40Neurotrophin signaling pathway_Homo sapiens_hsa047220.94231830
41Type II diabetes mellitus_Homo sapiens_hsa049300.94160752
42Adherens junction_Homo sapiens_hsa045200.93123379
43Morphine addiction_Homo sapiens_hsa050320.92122635
44Propanoate metabolism_Homo sapiens_hsa006400.91288231
45ECM-receptor interaction_Homo sapiens_hsa045120.91129766
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.87719351
47Vitamin B6 metabolism_Homo sapiens_hsa007500.87682093
48Melanogenesis_Homo sapiens_hsa049160.87413907
49Salivary secretion_Homo sapiens_hsa049700.86905362
50Dorso-ventral axis formation_Homo sapiens_hsa043200.85373287
51Endometrial cancer_Homo sapiens_hsa052130.84321135
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.84242376
53Thyroid hormone synthesis_Homo sapiens_hsa049180.82268160
54Circadian entrainment_Homo sapiens_hsa047130.81621002
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81603009
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81387735
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81052225
58Gastric acid secretion_Homo sapiens_hsa049710.80962203
59MAPK signaling pathway_Homo sapiens_hsa040100.80790102
60Cholinergic synapse_Homo sapiens_hsa047250.77589009
61Endocytosis_Homo sapiens_hsa041440.77294581
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73277463
63Ovarian steroidogenesis_Homo sapiens_hsa049130.73222951
64Platelet activation_Homo sapiens_hsa046110.72290871
65Collecting duct acid secretion_Homo sapiens_hsa049660.71583064
66ErbB signaling pathway_Homo sapiens_hsa040120.71101596
67Ras signaling pathway_Homo sapiens_hsa040140.70767988
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70372368
69Renin secretion_Homo sapiens_hsa049240.70305612
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69908075
71Arginine and proline metabolism_Homo sapiens_hsa003300.68464442
72Dopaminergic synapse_Homo sapiens_hsa047280.68404002
73Olfactory transduction_Homo sapiens_hsa047400.68200176
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.67974623
75beta-Alanine metabolism_Homo sapiens_hsa004100.66926858
76Mineral absorption_Homo sapiens_hsa049780.65774163
77Peroxisome_Homo sapiens_hsa041460.65670390
78mTOR signaling pathway_Homo sapiens_hsa041500.65555772
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.65314328
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65014945
81Prolactin signaling pathway_Homo sapiens_hsa049170.64444893
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63507565
83Synaptic vesicle cycle_Homo sapiens_hsa047210.62909051
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62565643
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.62252602
86Vibrio cholerae infection_Homo sapiens_hsa051100.61385725
87Cocaine addiction_Homo sapiens_hsa050300.61100569
88VEGF signaling pathway_Homo sapiens_hsa043700.60731718
89Proteoglycans in cancer_Homo sapiens_hsa052050.60484965
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60454252
91Lysosome_Homo sapiens_hsa041420.60003116
92FoxO signaling pathway_Homo sapiens_hsa040680.58596377
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57425155
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.57338483
95Hippo signaling pathway_Homo sapiens_hsa043900.57205689
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56052711
97PPAR signaling pathway_Homo sapiens_hsa033200.55181201
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54970851
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54846834
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54655956
101Pancreatic secretion_Homo sapiens_hsa049720.53429773
102Glucagon signaling pathway_Homo sapiens_hsa049220.53037300
103Long-term potentiation_Homo sapiens_hsa047200.52572631
104Choline metabolism in cancer_Homo sapiens_hsa052310.52363886
105Insulin signaling pathway_Homo sapiens_hsa049100.51815721
106Nicotine addiction_Homo sapiens_hsa050330.51601273
107Bile secretion_Homo sapiens_hsa049760.50698319
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50648434
109AMPK signaling pathway_Homo sapiens_hsa041520.50128955
110Rheumatoid arthritis_Homo sapiens_hsa053230.49324908
111Gap junction_Homo sapiens_hsa045400.49260105
112Phototransduction_Homo sapiens_hsa047440.48908456
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48018170
114Protein digestion and absorption_Homo sapiens_hsa049740.47781313
115Colorectal cancer_Homo sapiens_hsa052100.47656791
116Glycerolipid metabolism_Homo sapiens_hsa005610.46430660
117Non-small cell lung cancer_Homo sapiens_hsa052230.46380156
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46060885
119cAMP signaling pathway_Homo sapiens_hsa040240.45026019
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44863740
121Focal adhesion_Homo sapiens_hsa045100.44830882
122Phagosome_Homo sapiens_hsa041450.44441777
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42097416
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41813981
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40836296
126Oxytocin signaling pathway_Homo sapiens_hsa049210.40742095
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39336637
128GnRH signaling pathway_Homo sapiens_hsa049120.38928749
129Dilated cardiomyopathy_Homo sapiens_hsa054140.38816299
130Alzheimers disease_Homo sapiens_hsa050100.38716149
131Prion diseases_Homo sapiens_hsa050200.37739829
132Oxidative phosphorylation_Homo sapiens_hsa001900.36837793
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36632367
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.36473447
135Fatty acid degradation_Homo sapiens_hsa000710.35616029
136ABC transporters_Homo sapiens_hsa020100.35455673
137Amphetamine addiction_Homo sapiens_hsa050310.33786555
138Chemokine signaling pathway_Homo sapiens_hsa040620.33786029
139Rap1 signaling pathway_Homo sapiens_hsa040150.33771630
140Amoebiasis_Homo sapiens_hsa051460.33476843
141Autoimmune thyroid disease_Homo sapiens_hsa053200.32871152
142Pyruvate metabolism_Homo sapiens_hsa006200.31372054

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