SECISBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cAMP-mediated signaling (GO:0043951)6.21930170
2negative regulation of cytosolic calcium ion concentration (GO:0051481)6.12984522
3negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.91404722
4behavioral response to ethanol (GO:0048149)4.84510345
5piRNA metabolic process (GO:0034587)4.65089444
6neural tube formation (GO:0001841)4.52836282
7ether lipid metabolic process (GO:0046485)4.28554087
8histone H3-K9 modification (GO:0061647)4.21594652
9regulation of protein glycosylation (GO:0060049)4.17743202
10adult feeding behavior (GO:0008343)4.14910104
11DNA deamination (GO:0045006)4.06219932
12histone H3-K9 methylation (GO:0051567)4.02603974
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.98397750
14DNA strand elongation involved in DNA replication (GO:0006271)3.98024620
15telomere maintenance via semi-conservative replication (GO:0032201)3.92955645
16monoubiquitinated protein deubiquitination (GO:0035520)3.89696127
17DNA replication initiation (GO:0006270)3.88468404
18opioid receptor signaling pathway (GO:0038003)3.84360429
19tachykinin receptor signaling pathway (GO:0007217)3.81690525
20DNA strand elongation (GO:0022616)3.80844920
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78607535
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.73094752
23regulation of translation, ncRNA-mediated (GO:0045974)3.73094752
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.73094752
25positive regulation of gamma-delta T cell activation (GO:0046645)3.68769489
26telomere maintenance via recombination (GO:0000722)3.67590807
27thrombin receptor signaling pathway (GO:0070493)3.54093369
28pyrimidine dimer repair (GO:0006290)3.53740208
29positive regulation of cAMP-mediated signaling (GO:0043950)3.52299599
30positive regulation of B cell differentiation (GO:0045579)3.52145624
31ribosomal small subunit assembly (GO:0000028)3.51470711
32DNA unwinding involved in DNA replication (GO:0006268)3.50274538
33nuclear pore complex assembly (GO:0051292)3.49340642
34nuclear pore organization (GO:0006999)3.47377094
35ncRNA catabolic process (GO:0034661)3.46693713
36establishment of protein localization to Golgi (GO:0072600)3.44809440
37mitotic recombination (GO:0006312)3.36866891
38regulation of MHC class II biosynthetic process (GO:0045346)3.35973408
39peptidyl-lysine trimethylation (GO:0018023)3.31863488
40protein K11-linked deubiquitination (GO:0035871)3.28744733
41ribosomal large subunit biogenesis (GO:0042273)3.26957293
42N-terminal protein amino acid acetylation (GO:0006474)3.25494736
43IMP biosynthetic process (GO:0006188)3.24252448
44histone H3-K36 demethylation (GO:0070544)3.22084182
45intra-S DNA damage checkpoint (GO:0031573)3.20266353
46pore complex assembly (GO:0046931)3.11174965
47folic acid-containing compound biosynthetic process (GO:0009396)3.10254310
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.09347122
49DNA double-strand break processing (GO:0000729)3.08679403
50DNA replication-dependent nucleosome organization (GO:0034723)3.08473839
51DNA replication-dependent nucleosome assembly (GO:0006335)3.08473839
52formation of translation preinitiation complex (GO:0001731)3.07718601
53regulation of gene silencing by RNA (GO:0060966)3.06597090
54regulation of posttranscriptional gene silencing (GO:0060147)3.06597090
55regulation of gene silencing by miRNA (GO:0060964)3.06597090
56cilium or flagellum-dependent cell motility (GO:0001539)3.05587426
57protein targeting to Golgi (GO:0000042)3.05439206
58regulation of acrosome reaction (GO:0060046)3.04886502
59retrograde transport, vesicle recycling within Golgi (GO:0000301)3.04380165
60telomere maintenance via telomere lengthening (GO:0010833)3.01489366
61IMP metabolic process (GO:0046040)2.99034811
62gene silencing by RNA (GO:0031047)2.98875479
63adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97447290
64regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97042509
65negative regulation of glycoprotein biosynthetic process (GO:0010561)2.96753146
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96498636
67positive regulation of granulocyte differentiation (GO:0030854)2.96300481
68histone H2A acetylation (GO:0043968)2.95001512
69epithelial cilium movement (GO:0003351)2.94635711
70positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.93864903
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.93864903
72regulation of histone H3-K27 methylation (GO:0061085)2.86980946
73histone H4-K12 acetylation (GO:0043983)2.86076112
74response to muramyl dipeptide (GO:0032495)2.85631036
75rRNA modification (GO:0000154)2.85502690
76ribonucleoprotein complex biogenesis (GO:0022613)2.82626357
77chromatin remodeling at centromere (GO:0031055)2.81524273
78protein K48-linked deubiquitination (GO:0071108)2.80894097
79mitotic nuclear envelope disassembly (GO:0007077)2.80486056
80positive regulation of developmental pigmentation (GO:0048087)2.79831099
81ribosome biogenesis (GO:0042254)2.78642179
82regulation of gamma-delta T cell differentiation (GO:0045586)2.77541066
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77470849
84peptidyl-lysine methylation (GO:0018022)2.76693461
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76351154
86mRNA splice site selection (GO:0006376)2.76097503
87DNA duplex unwinding (GO:0032508)2.75294439
88rRNA methylation (GO:0031167)2.74292123
89nucleobase biosynthetic process (GO:0046112)2.73590390
90regulation of RIG-I signaling pathway (GO:0039535)2.72370394
91maturation of SSU-rRNA (GO:0030490)2.72195210
92DNA replication checkpoint (GO:0000076)2.71722835
93DNA geometric change (GO:0032392)2.71218807
943-UTR-mediated mRNA stabilization (GO:0070935)2.70314443
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69651534
96telomere maintenance (GO:0000723)2.69316332
97CENP-A containing nucleosome assembly (GO:0034080)2.69062937
98telomere organization (GO:0032200)2.68507739
99DNA alkylation (GO:0006305)2.67434704
100DNA methylation (GO:0006306)2.67434704
101tolerance induction (GO:0002507)2.67356252
102DNA methylation involved in gamete generation (GO:0043046)2.67142931
103histone H3-K4 methylation (GO:0051568)2.66555013
104regulation of memory T cell differentiation (GO:0043380)2.65617960
105maturation of 5.8S rRNA (GO:0000460)2.65407208
106cilium movement (GO:0003341)2.64943238
107regulation of gamma-delta T cell activation (GO:0046643)2.64571519
108histone mRNA metabolic process (GO:0008334)2.64172205
109left/right axis specification (GO:0070986)2.64093938
110mitotic chromosome condensation (GO:0007076)2.62308709
111positive regulation of defense response to virus by host (GO:0002230)2.61948074
112positive thymic T cell selection (GO:0045059)2.61474809
113histone lysine methylation (GO:0034968)2.60494638
114tRNA methylation (GO:0030488)2.60460158
115cornea development in camera-type eye (GO:0061303)2.58522542
116histone demethylation (GO:0016577)2.58263114
117regulation of cAMP-mediated signaling (GO:0043949)2.55559341
118interkinetic nuclear migration (GO:0022027)2.54977841
119single strand break repair (GO:0000012)2.52757557
120rRNA processing (GO:0006364)2.52373887
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52272298
122ribosome assembly (GO:0042255)2.51607166
123pseudouridine synthesis (GO:0001522)2.51523343
124mismatch repair (GO:0006298)2.51020838
125regulation of DNA endoreduplication (GO:0032875)2.50893470
126centriole replication (GO:0007099)2.50706562
127histone lysine demethylation (GO:0070076)2.50309637
128cytoplasmic mRNA processing body assembly (GO:0033962)2.49806365
129DNA replication-independent nucleosome assembly (GO:0006336)2.49637955
130DNA replication-independent nucleosome organization (GO:0034724)2.49637955
131DNA synthesis involved in DNA repair (GO:0000731)2.49589579
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.49358194
133regulation of histone H3-K9 methylation (GO:0051570)2.49111325
134retinal cone cell development (GO:0046549)2.48894775
135viral transcription (GO:0019083)2.48766578
136gene silencing (GO:0016458)2.48730513
137termination of RNA polymerase II transcription (GO:0006369)2.48341354
138regulation of chromatin silencing (GO:0031935)2.48334634
139negative regulation of DNA-templated transcription, elongation (GO:0032785)2.47754437
140negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.47754437
141negative regulation of interleukin-12 production (GO:0032695)2.47728580
142purine nucleobase biosynthetic process (GO:0009113)2.47520348
143regulation of meiosis I (GO:0060631)2.46565382
144translational termination (GO:0006415)2.45961386
145positive regulation of action potential (GO:0045760)2.45914914
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.45801149
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44720457
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44720457
149isotype switching (GO:0045190)2.44720457
150negative T cell selection (GO:0043383)2.44503118
151membrane disassembly (GO:0030397)2.44186216
152nuclear envelope disassembly (GO:0051081)2.44186216
153histone mRNA catabolic process (GO:0071044)2.43682301
154ribosomal small subunit biogenesis (GO:0042274)2.43456540
155regulation of collateral sprouting (GO:0048670)2.43360521
156translesion synthesis (GO:0019985)2.43146840
157rRNA metabolic process (GO:0016072)2.42823602
158protein localization to kinetochore (GO:0034501)2.42328572
159male meiosis (GO:0007140)2.42262486
160activated T cell proliferation (GO:0050798)2.42139176
161histone H3-K4 trimethylation (GO:0080182)2.41966529
162regulation of pigment cell differentiation (GO:0050932)2.41957154
163meiotic chromosome segregation (GO:0045132)2.41902404
164regulation of B cell differentiation (GO:0045577)2.41709138
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.41185727
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41185727
167axoneme assembly (GO:0035082)2.40281581
168NIK/NF-kappaB signaling (GO:0038061)2.39702513
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39545275
170regulation of mitotic spindle checkpoint (GO:1903504)2.39545275
171spliceosomal snRNP assembly (GO:0000387)2.38289525
172pre-miRNA processing (GO:0031054)2.37824014
173DNA conformation change (GO:0071103)2.37424968
174photoreceptor cell maintenance (GO:0045494)2.37082878
175histone H4-K16 acetylation (GO:0043984)2.36459667
176pyrimidine nucleobase catabolic process (GO:0006208)2.36401662
177negative thymic T cell selection (GO:0045060)2.35976316
178regulation of RNA export from nucleus (GO:0046831)2.35587280
179hepatocyte apoptotic process (GO:0097284)2.35412961
180sister chromatid cohesion (GO:0007062)2.34982997
181translational initiation (GO:0006413)2.34859115
182translational elongation (GO:0006414)2.34372354
183negative regulation of gene expression, epigenetic (GO:0045814)2.33870797
184DNA methylation or demethylation (GO:0044728)2.33829948
185spermatid development (GO:0007286)2.33737009
186microtubule depolymerization (GO:0007019)2.33723162
187negative regulation of histone methylation (GO:0031061)2.33627058
188regulation of histone methylation (GO:0031060)2.33542537
189regulation of gene silencing (GO:0060968)2.32262041
190mitotic G1/S transition checkpoint (GO:0044819)2.29476032
191histone H4-K5 acetylation (GO:0043981)2.29235626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81259706
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.18820630
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92605350
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84541708
5IGF1R_20145208_ChIP-Seq_DFB_Human2.82527336
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69729248
7TAF15_26573619_Chip-Seq_HEK293_Human2.67951499
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.67531616
9ZNF274_21170338_ChIP-Seq_K562_Hela2.58364051
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58147097
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53283353
12GBX2_23144817_ChIP-Seq_PC3_Human2.51669219
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.50787039
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50787039
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40476733
16VDR_22108803_ChIP-Seq_LS180_Human2.38080347
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.32074228
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30008379
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27513724
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26901954
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25907786
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25175450
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.23708944
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22767600
25EZH2_22144423_ChIP-Seq_EOC_Human2.21408187
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19387026
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19252845
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.15118205
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13853636
30MYC_22102868_ChIP-Seq_BL_Human2.13419212
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12044355
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.10074052
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98464838
34* GABP_17652178_ChIP-ChIP_JURKAT_Human1.97299389
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95287208
36VDR_21846776_ChIP-Seq_THP-1_Human1.94958166
37VDR_23849224_ChIP-Seq_CD4+_Human1.94155109
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94062919
39* ETS1_20019798_ChIP-Seq_JURKAT_Human1.92646677
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91589628
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88701919
42EWS_26573619_Chip-Seq_HEK293_Human1.88631291
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85708430
44FUS_26573619_Chip-Seq_HEK293_Human1.85626204
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84819766
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82304149
47FOXP3_21729870_ChIP-Seq_TREG_Human1.82037561
48ER_23166858_ChIP-Seq_MCF-7_Human1.81274321
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79862793
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79336851
51CBP_20019798_ChIP-Seq_JUKART_Human1.78797218
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78797218
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.78754612
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77133243
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75765767
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75680725
57STAT3_23295773_ChIP-Seq_U87_Human1.74384745
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73398392
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73046500
60P300_19829295_ChIP-Seq_ESCs_Human1.72041180
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71020090
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69589887
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.68021632
64* TCF4_23295773_ChIP-Seq_U87_Human1.65953359
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65393378
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64992597
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63277899
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63141870
69XRN2_22483619_ChIP-Seq_HELA_Human1.61954713
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60002309
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58849285
72* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57413643
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56631579
74SCL_19346495_ChIP-Seq_HPC-7_Human1.56023813
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55635914
76BCAT_22108803_ChIP-Seq_LS180_Human1.55277899
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53404955
78* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53377504
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53133419
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51576459
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51167738
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51014324
83SMAD4_21799915_ChIP-Seq_A2780_Human1.50493292
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49592077
85SPI1_23547873_ChIP-Seq_NB4_Human1.49206646
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48018199
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46647217
88AR_21572438_ChIP-Seq_LNCaP_Human1.44258207
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.43121710
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.43100321
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42468730
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.39939133
93* DCP1A_22483619_ChIP-Seq_HELA_Human1.39907022
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.39255464
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38561218
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38505321
97MAF_26560356_Chip-Seq_TH1_Human1.37793324
98RXR_22108803_ChIP-Seq_LS180_Human1.37136422
99CIITA_25753668_ChIP-Seq_RAJI_Human1.36753952
100* FLI1_21867929_ChIP-Seq_TH2_Mouse1.35988599
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34191529
102MYB_26560356_Chip-Seq_TH1_Human1.34047702
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33503503
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32521319
105AR_21909140_ChIP-Seq_LNCAP_Human1.32024138
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31498954
107MYB_26560356_Chip-Seq_TH2_Human1.30835631
108IRF1_19129219_ChIP-ChIP_H3396_Human1.29897725
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.29372798
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.28816156
111* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28100263
112AR_25329375_ChIP-Seq_VCAP_Human1.27951944
113* GABP_19822575_ChIP-Seq_HepG2_Human1.27946425
114ELK1_19687146_ChIP-ChIP_HELA_Human1.27656276
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27620962
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24835434
117KDM5A_27292631_Chip-Seq_BREAST_Human1.24428316
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.23806828
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23761906
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23531874
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23494778
122RUNX2_22187159_ChIP-Seq_PCA_Human1.23308696
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.23169174
124DROSHA_22980978_ChIP-Seq_HELA_Human1.23168181
125RUNX1_22412390_ChIP-Seq_EML_Mouse1.22493277
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22327567
127UTX_26944678_Chip-Seq_JUKART_Human1.21289167
128RUNX_20019798_ChIP-Seq_JUKART_Human1.20359304
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20357904
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20007412
131* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18389726
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18087899
133IRF8_21731497_ChIP-ChIP_J774_Mouse1.17922513
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17830160
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17789544
136TP53_16413492_ChIP-PET_HCT116_Human1.16961430
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16680032
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16565863
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16391172
140TP53_22573176_ChIP-Seq_HFKS_Human1.15798965
141TTF2_22483619_ChIP-Seq_HELA_Human1.15291815
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.14689264
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14389546
144CRX_20693478_ChIP-Seq_RETINA_Mouse1.13366013
145* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13357573
146SOX2_19829295_ChIP-Seq_ESCs_Human1.13165341
147NANOG_19829295_ChIP-Seq_ESCs_Human1.13165341
148* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12725746
149NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11729579
150VDR_24763502_ChIP-Seq_THP-1_Human1.11705120
151TCF4_22108803_ChIP-Seq_LS180_Human1.11574651
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11277321
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11112264
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10355724
155TFEB_21752829_ChIP-Seq_HELA_Human1.10065243
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09876088
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09778973
158RNF2_27304074_Chip-Seq_NSC_Mouse1.09244769
159SOX2_21211035_ChIP-Seq_LN229_Gbm1.08983781
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.08133483
161GATA3_27048872_Chip-Seq_THYMUS_Human1.07812158
162* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07782532
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07358885
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06837200
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06477546
166MAF_26560356_Chip-Seq_TH2_Human1.06079948
167GATA1_22025678_ChIP-Seq_K562_Human1.05311128
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04778042
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04701191
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03856056
171* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02041635
172ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01840130
173ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01702222
174NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01025647
175* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00951294
176NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00680516
177MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00353670
178SMRT_27268052_Chip-Seq_Bcells_Human1.00095135
179TCF4_18268006_ChIP-ChIP_LS174T_Human0.99676359
180KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99205980
181ESR1_20079471_ChIP-ChIP_T-47D_Human0.99123249
182POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98880916
183P53_22387025_ChIP-Seq_ESCs_Mouse0.97952803
184SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97720642
185E2F1_18555785_Chip-Seq_ESCs_Mouse0.97275416
186EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96969164
187PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96157732
188GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95607344
189* KDM2B_26808549_Chip-Seq_REH_Human0.95165013
190HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93575139
191RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93340984
192GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92531671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.65422567
2MP0008057_abnormal_DNA_replication3.46555079
3MP0010094_abnormal_chromosome_stability3.39513504
4MP0002396_abnormal_hematopoietic_system3.21343816
5MP0008058_abnormal_DNA_repair3.03210267
6MP0003693_abnormal_embryo_hatching3.00964253
7MP0000569_abnormal_digit_pigmentation2.79909750
8MP0003111_abnormal_nucleus_morphology2.76569833
9MP0001968_abnormal_touch/_nociception2.70445142
10MP0005671_abnormal_response_to2.68831152
11MP0003077_abnormal_cell_cycle2.64739864
12MP0003763_abnormal_thymus_physiology2.61483486
13MP0003880_abnormal_central_pattern2.45926950
14MP0001800_abnormal_humoral_immune2.23908356
15MP0000685_abnormal_immune_system2.11704631
16MP0002398_abnormal_bone_marrow2.08840468
17MP0001835_abnormal_antigen_presentation2.05935514
18MP0009333_abnormal_splenocyte_physiolog2.04103672
19MP0004957_abnormal_blastocyst_morpholog1.99893488
20MP0002876_abnormal_thyroid_physiology1.99730409
21MP0000689_abnormal_spleen_morphology1.98990489
22MP0008995_early_reproductive_senescence1.95731784
23MP0003806_abnormal_nucleotide_metabolis1.89934885
24MP0004808_abnormal_hematopoietic_stem1.88188874
25MP0002723_abnormal_immune_serum1.88171578
26MP0002009_preneoplasia1.87289834
27MP0002722_abnormal_immune_system1.84711700
28MP0002452_abnormal_antigen_presenting1.83671386
29MP0003121_genomic_imprinting1.83427663
30MP0003436_decreased_susceptibility_to1.83120954
31MP0002420_abnormal_adaptive_immunity1.79053120
32MP0003890_abnormal_embryonic-extraembry1.76516236
33MP0000716_abnormal_immune_system1.75714608
34MP0003646_muscle_fatigue1.74407925
35MP0001819_abnormal_immune_cell1.74260744
36MP0005000_abnormal_immune_tolerance1.71003576
37MP0008007_abnormal_cellular_replicative1.70372086
38MP0005551_abnormal_eye_electrophysiolog1.68033552
39MP0000703_abnormal_thymus_morphology1.66506528
40MP0001790_abnormal_immune_system1.65328967
41MP0005387_immune_system_phenotype1.65328967
42MP0009785_altered_susceptibility_to1.64291073
43MP0005645_abnormal_hypothalamus_physiol1.64097627
44MP0002429_abnormal_blood_cell1.59745270
45MP0005025_abnormal_response_to1.59144401
46MP0003195_calcinosis1.59072378
47MP0008877_abnormal_DNA_methylation1.58240274
48MP0003303_peritoneal_inflammation1.57920532
49MP0005310_abnormal_salivary_gland1.57724427
50MP0002405_respiratory_system_inflammati1.57112742
51MP0000490_abnormal_crypts_of1.56682978
52MP0006292_abnormal_olfactory_placode1.53521216
53MP0009780_abnormal_chondrocyte_physiolo1.50461688
54MP0005464_abnormal_platelet_physiology1.50271785
55MP0000371_diluted_coat_color1.49672728
56MP0005174_abnormal_tail_pigmentation1.47803609
57MP0002822_catalepsy1.47331706
58MP0001853_heart_inflammation1.46218161
59MP0001501_abnormal_sleep_pattern1.44793655
60MP0005397_hematopoietic_system_phenotyp1.44490805
61MP0001545_abnormal_hematopoietic_system1.44490805
62MP0001529_abnormal_vocalization1.44457360
63MP0002419_abnormal_innate_immunity1.41899995
64MP0002019_abnormal_tumor_incidence1.36559510
65MP0010155_abnormal_intestine_physiology1.36266353
66MP0005075_abnormal_melanosome_morpholog1.35875633
67MP0005499_abnormal_olfactory_system1.35812688
68MP0005394_taste/olfaction_phenotype1.35812688
69MP0000383_abnormal_hair_follicle1.35556089
70MP0002735_abnormal_chemical_nociception1.35337479
71MP0000631_abnormal_neuroendocrine_gland1.35324576
72MP0000778_abnormal_nervous_system1.34754710
73MP0001730_embryonic_growth_arrest1.34713647
74MP0003866_abnormal_defecation1.33870249
75MP0006035_abnormal_mitochondrial_morpho1.32437791
76MP0005646_abnormal_pituitary_gland1.32195399
77MP0003724_increased_susceptibility_to1.31852693
78MP0000350_abnormal_cell_proliferation1.29246849
79MP0003698_abnormal_male_reproductive1.27701252
80MP0003186_abnormal_redox_activity1.24513556
81MP0002736_abnormal_nociception_after1.22928818
82MP0003183_abnormal_peptide_metabolism1.22531655
83MP0009764_decreased_sensitivity_to1.19606676
84MP0005451_abnormal_body_composition1.18770462
85MP0003567_abnormal_fetal_cardiomyocyte1.18742079
86MP0006276_abnormal_autonomic_nervous1.18345515
87MP0008789_abnormal_olfactory_epithelium1.17220288
88MP0008872_abnormal_physiological_respon1.16795524
89MP0004142_abnormal_muscle_tone1.16122301
90MP0000313_abnormal_cell_death1.15840396
91MP0002277_abnormal_respiratory_mucosa1.12572504
92MP0003221_abnormal_cardiomyocyte_apopto1.12020785
93MP0008932_abnormal_embryonic_tissue1.11318952
94MP0008469_abnormal_protein_level1.09265259
95MP0002166_altered_tumor_susceptibility1.08505151
96MP0008961_abnormal_basal_metabolism1.08126892
97MP0001845_abnormal_inflammatory_respons1.07558060
98MP0004043_abnormal_pH_regulation1.06923051
99MP0009763_increased_sensitivity_to1.05830808
100MP0002102_abnormal_ear_morphology1.05486563
101MP0005380_embryogenesis_phenotype1.05131309
102MP0001672_abnormal_embryogenesis/_devel1.05131309
103MP0009278_abnormal_bone_marrow1.04598161
104MP0003984_embryonic_growth_retardation1.03828261
105MP0009703_decreased_birth_body1.03021898
106MP0002148_abnormal_hypersensitivity_rea1.02322426
107MP0002088_abnormal_embryonic_growth/wei1.00827309
108MP0000465_gastrointestinal_hemorrhage1.00633340
109MP0003828_pulmonary_edema0.99997572
110MP0002272_abnormal_nervous_system0.99868790
111MP0002557_abnormal_social/conspecific_i0.99361283
112MP0009046_muscle_twitch0.99358750
113MP0002075_abnormal_coat/hair_pigmentati0.99189219
114MP0001984_abnormal_olfaction0.98303941
115MP0003172_abnormal_lysosome_physiology0.97906263
116MP0005058_abnormal_lysosome_morphology0.95894810
117MP0001873_stomach_inflammation0.95370343
118MP0002210_abnormal_sex_determination0.95199482
119MP0002067_abnormal_sensory_capabilities0.95067538
120MP0002751_abnormal_autonomic_nervous0.93198864
121MP0002928_abnormal_bile_duct0.92983965
122MP0003122_maternal_imprinting0.91524835
123MP0003718_maternal_effect0.89916962
124MP0001486_abnormal_startle_reflex0.89536480
125MP0009745_abnormal_behavioral_response0.88368934
126MP0002080_prenatal_lethality0.87315137
127MP0003136_yellow_coat_color0.86606094
128MP0004924_abnormal_behavior0.86443044
129MP0005386_behavior/neurological_phenoty0.86443044
130MP0006082_CNS_inflammation0.86294085
131MP0010678_abnormal_skin_adnexa0.84885605
132MP0003300_gastrointestinal_ulcer0.84221640
133MP0002733_abnormal_thermal_nociception0.84155339
134MP0002653_abnormal_ependyma_morphology0.83901029
135MP0001145_abnormal_male_reproductive0.83809376
136MP0003786_premature_aging0.83081155
137MP0002006_tumorigenesis0.81711636
138MP0003045_fibrosis0.79756512
139MP0005365_abnormal_bile_salt0.79561489
140MP0002933_joint_inflammation0.79471868
141MP0000598_abnormal_liver_morphology0.79020761
142MP0002086_abnormal_extraembryonic_tissu0.78326307
143MP0000427_abnormal_hair_cycle0.77230183
144MP0003633_abnormal_nervous_system0.76937453
145MP0001986_abnormal_taste_sensitivity0.76918869
146MP0005083_abnormal_biliary_tract0.76834370
147MP0000653_abnormal_sex_gland0.76828198
148MP0005666_abnormal_adipose_tissue0.76198866
149MP0004147_increased_porphyrin_level0.76028042
150MP0005253_abnormal_eye_physiology0.75913482
151MP0010307_abnormal_tumor_latency0.75602099
152MP0005023_abnormal_wound_healing0.75595951
153MP0002638_abnormal_pupillary_reflex0.73635095
154MP0003656_abnormal_erythrocyte_physiolo0.73456017
155MP0000343_altered_response_to0.73153273
156MP0001764_abnormal_homeostasis0.72879497
157MP0002132_abnormal_respiratory_system0.71359267
158MP0000015_abnormal_ear_pigmentation0.71162495
159MP0004197_abnormal_fetal_growth/weight/0.71079313
160MP0004264_abnormal_extraembryonic_tissu0.70747280
161MP0003635_abnormal_synaptic_transmissio0.70510515
162MP0001186_pigmentation_phenotype0.70395202
163MP0001697_abnormal_embryo_size0.70253475
164MP0000858_altered_metastatic_potential0.69181061
165MP0002572_abnormal_emotion/affect_behav0.68853533
166MP0002063_abnormal_learning/memory/cond0.68821712
167MP0001970_abnormal_pain_threshold0.68768658
168MP0001324_abnormal_eye_pigmentation0.68618413
169MP0004130_abnormal_muscle_cell0.68549143
170MP0006036_abnormal_mitochondrial_physio0.67860549
171MP0003937_abnormal_limbs/digits/tail_de0.67801142
172MP0001929_abnormal_gametogenesis0.67423273
173MP0000230_abnormal_systemic_arterial0.67420827
174MP0002095_abnormal_skin_pigmentation0.66543933
175MP0002229_neurodegeneration0.66511831
176MP0000609_abnormal_liver_physiology0.66475608
177MP0002138_abnormal_hepatobiliary_system0.65495988

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.77777031
2Panhypogammaglobulinemia (HP:0003139)4.25775548
3Broad alveolar ridges (HP:0000187)3.98119504
4Intestinal atresia (HP:0011100)3.94536952
5Reticulocytopenia (HP:0001896)3.82810413
6Recurrent viral infections (HP:0004429)3.81899250
7Birth length less than 3rd percentile (HP:0003561)3.78578368
8Chromsome breakage (HP:0040012)3.74324465
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73335693
10Gaze-evoked nystagmus (HP:0000640)3.49446800
11IgM deficiency (HP:0002850)3.43745680
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.41337726
13T lymphocytopenia (HP:0005403)3.38183258
14Aplastic anemia (HP:0001915)3.34113922
15Abnormality of the fingertips (HP:0001211)3.29714992
16Abnormality of T cell number (HP:0011839)3.27094597
17Chronic otitis media (HP:0000389)3.24469170
18Pancreatic islet-cell hyperplasia (HP:0004510)3.19173039
19Agammaglobulinemia (HP:0004432)3.15973559
20Tented upper lip vermilion (HP:0010804)3.04143881
21Chronic mucocutaneous candidiasis (HP:0002728)2.99415614
22Recurrent cutaneous fungal infections (HP:0011370)2.99415614
23Recurrent fungal infections (HP:0002841)2.96649579
24Abnormality of T cells (HP:0002843)2.96078260
25Abnormality of the aortic arch (HP:0012303)2.88531579
26Genetic anticipation (HP:0003743)2.88222603
27Severe combined immunodeficiency (HP:0004430)2.85643972
28Abnormality of T cell physiology (HP:0011840)2.78057936
29Pancreatic cysts (HP:0001737)2.74105293
30Combined immunodeficiency (HP:0005387)2.72981378
31Thickened helices (HP:0000391)2.70443351
32Hyperventilation (HP:0002883)2.69855044
33* Thyroid-stimulating hormone excess (HP:0002925)2.62481575
34Broad-based gait (HP:0002136)2.61666996
35Abnormality of chromosome stability (HP:0003220)2.61594038
36Breast hypoplasia (HP:0003187)2.61571997
37Abnormal number of erythroid precursors (HP:0012131)2.60008013
38Colitis (HP:0002583)2.58649926
39Protruding tongue (HP:0010808)2.58257172
40Recurrent abscess formation (HP:0002722)2.56924505
41Stomach cancer (HP:0012126)2.56761923
42Chronic hepatic failure (HP:0100626)2.56470895
43Acute myeloid leukemia (HP:0004808)2.55343254
44Recurrent skin infections (HP:0001581)2.55047543
45Lymphoma (HP:0002665)2.52449765
46Abnormality of pyrimidine metabolism (HP:0004353)2.52394705
47Recurrent bacterial skin infections (HP:0005406)2.52037540
48Type I transferrin isoform profile (HP:0003642)2.51056166
49Elevated erythrocyte sedimentation rate (HP:0003565)2.48976170
50Pancytopenia (HP:0001876)2.46178546
51Progressive cerebellar ataxia (HP:0002073)2.44634747
52Thrombocytosis (HP:0001894)2.44564469
53Congenital stationary night blindness (HP:0007642)2.44196807
54Inflammation of the large intestine (HP:0002037)2.43290977
55Recurrent bronchitis (HP:0002837)2.42450303
56Gastrointestinal inflammation (HP:0004386)2.41081998
57Absent speech (HP:0001344)2.40950367
58Truncal obesity (HP:0001956)2.39475372
59Asplenia (HP:0001746)2.39322288
60Duplicated collecting system (HP:0000081)2.37754935
61Abnormality of cells of the erythroid lineage (HP:0012130)2.37574358
62Optic nerve hypoplasia (HP:0000609)2.37309253
63Myelodysplasia (HP:0002863)2.35541962
64Nephronophthisis (HP:0000090)2.28529228
65IgG deficiency (HP:0004315)2.28512804
66Abnormality of B cell number (HP:0010975)2.27654042
67B lymphocytopenia (HP:0010976)2.27654042
68Lissencephaly (HP:0001339)2.27546291
69Agitation (HP:0000713)2.27527605
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27034553
71Encephalitis (HP:0002383)2.26002962
72Abnormality of the renal medulla (HP:0100957)2.25976973
73Atonic seizures (HP:0010819)2.25606286
74Nephroblastoma (Wilms tumor) (HP:0002667)2.24935246
75Pancreatic fibrosis (HP:0100732)2.24812361
76Ectopic kidney (HP:0000086)2.19880723
77Pallor (HP:0000980)2.19800566
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.19770508
79Molar tooth sign on MRI (HP:0002419)2.19314847
80Abnormality of midbrain morphology (HP:0002418)2.19314847
81Febrile seizures (HP:0002373)2.19114097
82Dialeptic seizures (HP:0011146)2.18465978
83Impulsivity (HP:0100710)2.17767822
84Embryonal renal neoplasm (HP:0011794)2.17740742
85Leukopenia (HP:0001882)2.17613627
86Abnormality of the labia minora (HP:0012880)2.16992768
87Attenuation of retinal blood vessels (HP:0007843)2.16670357
88Cerebral hypomyelination (HP:0006808)2.16325798
89Depressed nasal tip (HP:0000437)2.16031640
90Fair hair (HP:0002286)2.14910232
91Abnormality of the renal collecting system (HP:0004742)2.14449288
92Papillary thyroid carcinoma (HP:0002895)2.10850620
93Petechiae (HP:0000967)2.10831692
94Basal cell carcinoma (HP:0002671)2.08348988
95Prominent nose (HP:0000448)2.07888445
96Medial flaring of the eyebrow (HP:0010747)2.07446547
97Lymphopenia (HP:0001888)2.06725928
98Abnormality of the preputium (HP:0100587)2.06662390
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.05212949
100Abnormality of the pancreatic islet cells (HP:0006476)2.04676616
101Abnormality of endocrine pancreas physiology (HP:0012093)2.04676616
102Gastrointestinal atresia (HP:0002589)2.04600807
103Meningitis (HP:0001287)2.03815602
104IgA deficiency (HP:0002720)2.03323766
105Cellulitis (HP:0100658)2.03034949
106Drooling (HP:0002307)2.02671791
107Bone marrow hypocellularity (HP:0005528)2.02290629
108Aplasia/Hypoplasia of the spleen (HP:0010451)2.01896339
109Oral leukoplakia (HP:0002745)2.01765612
110True hermaphroditism (HP:0010459)2.00773585
111Poor coordination (HP:0002370)2.00703423
112Central scotoma (HP:0000603)1.97636258
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97515535
114Gait imbalance (HP:0002141)1.97449491
115Autoimmune thrombocytopenia (HP:0001973)1.97000765
116Excessive salivation (HP:0003781)1.96914534
117Abnormality of the ileum (HP:0001549)1.96797623
118Prolonged bleeding time (HP:0003010)1.96093320
119Abnormality of the renal cortex (HP:0011035)1.95721127
120Hypoplasia of the thymus (HP:0000778)1.92857941
121Macrocytic anemia (HP:0001972)1.92272496
122Meckel diverticulum (HP:0002245)1.91566561
123Abnormality of reticulocytes (HP:0004312)1.89102900
124Reduced antithrombin III activity (HP:0001976)1.88820482
125Stomatitis (HP:0010280)1.88165533
126Granulocytopenia (HP:0001913)1.88085179
127Amaurosis fugax (HP:0100576)1.87851862
128Hip dysplasia (HP:0001385)1.87407307
129Abnormality of DNA repair (HP:0003254)1.87133860
130Premature ovarian failure (HP:0008209)1.86353758
131Abnormal hair whorl (HP:0010721)1.84994516
132Amyotrophic lateral sclerosis (HP:0007354)1.84797131
133Tubular atrophy (HP:0000092)1.84264763
134Tubulointerstitial nephritis (HP:0001970)1.82917745
135Neonatal respiratory distress (HP:0002643)1.82864002
136Epistaxis (HP:0000421)1.82132478
137Congenital primary aphakia (HP:0007707)1.80172105
138Ocular albinism (HP:0001107)1.79880103
139Thyroiditis (HP:0100646)1.79878286
140Widely spaced teeth (HP:0000687)1.79724206
141Focal seizures (HP:0007359)1.78192472
142Pustule (HP:0200039)1.77070402
143Focal motor seizures (HP:0011153)1.76804434
144Large for gestational age (HP:0001520)1.76537905
145Progressive inability to walk (HP:0002505)1.76489958
146Recurrent sinusitis (HP:0011108)1.76098376
147Hypoplastic iliac wings (HP:0002866)1.75832592
148Decreased circulating renin level (HP:0003351)1.75816492
149Cerebellar dysplasia (HP:0007033)1.75386328
150Medulloblastoma (HP:0002885)1.75207601
151Long eyelashes (HP:0000527)1.74980340
152Exertional dyspnea (HP:0002875)1.73998795
153Genital tract atresia (HP:0001827)1.73523454
154Ependymoma (HP:0002888)1.72546190
155Vacuolated lymphocytes (HP:0001922)1.71874215
156Abnormality of the columella (HP:0009929)1.71677041
157Cystic liver disease (HP:0006706)1.71550184
158Pendular nystagmus (HP:0012043)1.71447052
159Type II lissencephaly (HP:0007260)1.70929968
160Mediastinal lymphadenopathy (HP:0100721)1.70604385
161Neutropenia (HP:0001875)1.69960872
162Abnormal ciliary motility (HP:0012262)1.69520923
163Abnormality of the alveolar ridges (HP:0006477)1.68748091
164Abnormality of eosinophils (HP:0001879)1.68210929
165Leukocytosis (HP:0001974)1.68030055
166Renal cortical cysts (HP:0000803)1.67882789
167Clubbing of toes (HP:0100760)1.67768244
168Gastrointestinal stroma tumor (HP:0100723)1.67395167
169Clumsiness (HP:0002312)1.67269290
170Aplasia/Hypoplasia of the thymus (HP:0010515)1.67249707
171Centrally nucleated skeletal muscle fibers (HP:0003687)1.67041441
172Neoplasm of the tracheobronchial system (HP:0100552)1.66117176
173Hypochromic microcytic anemia (HP:0004840)1.65654504
174Pachygyria (HP:0001302)1.64402363
175Abnormal respiratory motile cilium morphology (HP:0005938)1.64259140
176Abnormal respiratory epithelium morphology (HP:0012253)1.64259140
177Generalized hypopigmentation of hair (HP:0011358)1.63186583
178Patellar aplasia (HP:0006443)1.62998379
179Nephrogenic diabetes insipidus (HP:0009806)1.62874023
180Inability to walk (HP:0002540)1.62426615
181Scotoma (HP:0000575)1.62123500
182Vaginal atresia (HP:0000148)1.62079407
183Astigmatism (HP:0000483)1.60513823
184Absent/shortened dynein arms (HP:0200106)1.59986808
185Dynein arm defect of respiratory motile cilia (HP:0012255)1.59986808
186Oligodactyly (hands) (HP:0001180)1.58196367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05754573
2ADRBK23.72136692
3MAP4K13.47909881
4ACVR1B3.10153792
5MAP2K32.72734643
6TNIK2.63277088
7MAP3K62.43192704
8CDC72.22935206
9WEE12.07847092
10EEF2K2.07160747
11MAPK132.03776013
12ZAP702.00487050
13WNK31.98157476
14EIF2AK31.98015915
15NEK21.91559744
16NLK1.87055857
17MAP3K41.86557049
18SRPK11.83327734
19RPS6KB21.77500716
20NME21.71628963
21MAP3K141.71159029
22TXK1.67153205
23IKBKB1.64750485
24AKT31.63735693
25IRAK11.63653434
26ZAK1.63417597
27BMPR1B1.62476731
28BTK1.61148878
29TLK11.60181708
30MAP4K21.59814723
31PASK1.59626492
32IRAK41.59370296
33STK161.57665524
34JAK31.55129976
35PNCK1.53205489
36KIT1.51777332
37EPHA41.49403247
38TYK21.45927174
39CASK1.42844149
40TRIM281.41539710
41STK101.40275039
42MAP3K101.40247269
43IKBKE1.38198830
44RPS6KA41.36127247
45CDK121.35402949
46BCR1.34281802
47SGK21.33868302
48CAMK1G1.33841967
49PINK11.30707794
50TEC1.30658769
51ATR1.26816826
52CDK71.25863604
53PIM11.25809992
54VRK11.22796957
55ITK1.20745556
56DYRK1A1.20553266
57BRD41.19916610
58TBK11.19606786
59MAPKAPK31.19425519
60STK41.15433826
61TNK21.13217372
62CSK1.10319685
63FLT31.09676408
64LCK1.08626395
65PIM21.07310771
66ADRBK11.06424185
67KDR1.04816176
68DYRK21.04478512
69INSRR1.03334800
70MST41.01608284
71EIF2AK11.00993614
72CDK40.99527598
73SCYL20.98856697
74CSF1R0.98263795
75MARK10.96138575
76YES10.94967902
77CHUK0.92765195
78NUAK10.92045596
79IRAK30.91651256
80CHEK10.90443919
81ERBB20.88227864
82TSSK60.88163160
83MAP2K70.86270212
84LYN0.85826620
85SIK20.85459338
86PRKCE0.85166611
87PLK10.82805283
88CHEK20.82702078
89GRK10.82267540
90CDK190.81733969
91MKNK20.80757344
92TYRO30.80441048
93CCNB10.79547617
94MKNK10.79455428
95ICK0.79047647
96FGFR20.78043395
97AURKB0.77856883
98CAMK40.77157664
99SGK2230.76390047
100SGK4940.76390047
101MAP3K110.74744973
102OXSR10.74683956
103BRSK20.72738770
104PIK3CG0.72294327
105EPHA30.71243356
106MAP3K70.70480564
107SGK10.68781090
108CAMK1D0.68470173
109BUB10.68115160
110PLK20.67542261
111EIF2AK20.67228182
112ERBB30.67150294
113TGFBR10.66844329
114FES0.66469285
115TTK0.65926777
116TRPM70.65902381
117SYK0.65210000
118BCKDK0.64462011
119PRKCG0.64437683
120CLK10.63069712
121MAPK110.61426221
122PTK2B0.61243962
123CDK30.61146863
124LRRK20.59901578
125MARK20.58624537
126PRKD20.58472159
127DYRK1B0.58110731
128NTRK20.57344070
129GRK60.56634526
130FGR0.56508032
131RAF10.55727466
132DYRK30.55398841
133MARK30.55307231
134PAK30.54900540
135PLK40.54611061
136TAOK30.52350693
137SGK30.52035273
138CDK20.51808536
139CSNK1A1L0.50554238
140ATM0.50534605
141MELK0.50532492
142MAP3K80.50189356
143CSNK2A20.50174674
144BMX0.47473152
145PRKAA10.46467740
146STK30.45781257
147CSNK1D0.45735751
148RPS6KA50.45544336
149STK110.44858426
150MAP2K40.44626694
151MTOR0.43746769
152RIPK40.43317663
153CAMK10.43116665
154SIK30.42918838
155HCK0.42776988
156PRKAA20.42557069
157DAPK20.41662935
158MAP3K50.41472906
159CAMKK20.41394922
160BLK0.41298580
161CSNK2A10.40949138
162MAPKAPK20.39151316
163MAPK100.36555830
164GSK3B0.35594047

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40585064
2Mismatch repair_Homo sapiens_hsa034303.55234837
3Base excision repair_Homo sapiens_hsa034102.92487843
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62785543
5Homologous recombination_Homo sapiens_hsa034402.61536026
6Dorso-ventral axis formation_Homo sapiens_hsa043202.50626201
7One carbon pool by folate_Homo sapiens_hsa006702.49330440
8Spliceosome_Homo sapiens_hsa030402.45122813
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42295547
10Ribosome_Homo sapiens_hsa030102.40447442
11Primary immunodeficiency_Homo sapiens_hsa053402.40063612
12Non-homologous end-joining_Homo sapiens_hsa034502.36933191
13RNA polymerase_Homo sapiens_hsa030202.35214823
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12053415
15RNA transport_Homo sapiens_hsa030132.06885610
16Fanconi anemia pathway_Homo sapiens_hsa034601.95581791
17Pyrimidine metabolism_Homo sapiens_hsa002401.91416492
18Nucleotide excision repair_Homo sapiens_hsa034201.85513199
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72135760
20Taste transduction_Homo sapiens_hsa047421.68290067
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.61350678
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58852780
23RNA degradation_Homo sapiens_hsa030181.53685308
24Olfactory transduction_Homo sapiens_hsa047401.52666003
25Linoleic acid metabolism_Homo sapiens_hsa005911.51818035
26Cell cycle_Homo sapiens_hsa041101.50558419
27Proteasome_Homo sapiens_hsa030501.49789278
28Systemic lupus erythematosus_Homo sapiens_hsa053221.49685494
29Selenocompound metabolism_Homo sapiens_hsa004501.47913755
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45350615
31Morphine addiction_Homo sapiens_hsa050321.40928937
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40834639
33Herpes simplex infection_Homo sapiens_hsa051681.38288417
34Measles_Homo sapiens_hsa051621.34576941
35Circadian rhythm_Homo sapiens_hsa047101.34253153
36Folate biosynthesis_Homo sapiens_hsa007901.32908478
37Butanoate metabolism_Homo sapiens_hsa006501.32349086
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30312345
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29655079
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.29406800
41mRNA surveillance pathway_Homo sapiens_hsa030151.29263264
42Regulation of autophagy_Homo sapiens_hsa041401.28550848
43Basal transcription factors_Homo sapiens_hsa030221.27984460
44Nicotine addiction_Homo sapiens_hsa050331.24440570
45Long-term depression_Homo sapiens_hsa047301.23776032
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22829083
47p53 signaling pathway_Homo sapiens_hsa041151.22783597
48Choline metabolism in cancer_Homo sapiens_hsa052311.22576238
49Glycerolipid metabolism_Homo sapiens_hsa005611.14949406
50Glutamatergic synapse_Homo sapiens_hsa047241.13540594
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12816125
52Antigen processing and presentation_Homo sapiens_hsa046121.11456164
53FoxO signaling pathway_Homo sapiens_hsa040681.11111533
54B cell receptor signaling pathway_Homo sapiens_hsa046621.10995805
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09398436
56Serotonergic synapse_Homo sapiens_hsa047261.08863672
57Type II diabetes mellitus_Homo sapiens_hsa049301.06589696
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.06183400
59Leishmaniasis_Homo sapiens_hsa051401.05126825
60Lysine degradation_Homo sapiens_hsa003101.05054752
61Epstein-Barr virus infection_Homo sapiens_hsa051691.04346816
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.04294693
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04057917
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.03306021
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02169989
66Legionellosis_Homo sapiens_hsa051341.00738098
67Circadian entrainment_Homo sapiens_hsa047130.99809434
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98345160
69Purine metabolism_Homo sapiens_hsa002300.95860063
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.94908182
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92558338
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91774746
73Hematopoietic cell lineage_Homo sapiens_hsa046400.91346071
74Caffeine metabolism_Homo sapiens_hsa002320.90962417
75T cell receptor signaling pathway_Homo sapiens_hsa046600.88703424
76Viral carcinogenesis_Homo sapiens_hsa052030.88616195
77Inositol phosphate metabolism_Homo sapiens_hsa005620.88562055
78Colorectal cancer_Homo sapiens_hsa052100.86180716
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83444775
80Cholinergic synapse_Homo sapiens_hsa047250.83001426
81Endometrial cancer_Homo sapiens_hsa052130.82493126
82Ether lipid metabolism_Homo sapiens_hsa005650.81948066
83Allograft rejection_Homo sapiens_hsa053300.81823571
84Other glycan degradation_Homo sapiens_hsa005110.80621398
85Asthma_Homo sapiens_hsa053100.80077394
86Osteoclast differentiation_Homo sapiens_hsa043800.79265909
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78615877
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77470084
89Pentose phosphate pathway_Homo sapiens_hsa000300.76312843
90Glutathione metabolism_Homo sapiens_hsa004800.76202205
91Chemokine signaling pathway_Homo sapiens_hsa040620.76066987
92Protein export_Homo sapiens_hsa030600.75363936
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74417272
94Nitrogen metabolism_Homo sapiens_hsa009100.73439330
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71839990
96Ovarian steroidogenesis_Homo sapiens_hsa049130.71122239
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70925803
98Acute myeloid leukemia_Homo sapiens_hsa052210.70576284
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.69982450
100Autoimmune thyroid disease_Homo sapiens_hsa053200.68239928
101Apoptosis_Homo sapiens_hsa042100.67726864
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67190278
103Prolactin signaling pathway_Homo sapiens_hsa049170.66929536
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66206297
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65942489
106Non-small cell lung cancer_Homo sapiens_hsa052230.65762803
107Influenza A_Homo sapiens_hsa051640.65433781
108Calcium signaling pathway_Homo sapiens_hsa040200.65231453
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65114282
110Prostate cancer_Homo sapiens_hsa052150.64543253
111Biosynthesis of amino acids_Homo sapiens_hsa012300.64049587
112Sphingolipid metabolism_Homo sapiens_hsa006000.62854817
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62554652
114ErbB signaling pathway_Homo sapiens_hsa040120.62420802
115Sulfur relay system_Homo sapiens_hsa041220.60356005
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.59590549
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57701009
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.57272446
119Estrogen signaling pathway_Homo sapiens_hsa049150.56643726
120Shigellosis_Homo sapiens_hsa051310.56369264
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56092714
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55557427
123GABAergic synapse_Homo sapiens_hsa047270.55405871
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.54003659
125Type I diabetes mellitus_Homo sapiens_hsa049400.53083228
126ABC transporters_Homo sapiens_hsa020100.52965052
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52364242
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.51652303
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50828364
130Hepatitis B_Homo sapiens_hsa051610.49753370
131Small cell lung cancer_Homo sapiens_hsa052220.49671216
132MAPK signaling pathway_Homo sapiens_hsa040100.49633620
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49444051
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48142932
135Salivary secretion_Homo sapiens_hsa049700.48048945
136mTOR signaling pathway_Homo sapiens_hsa041500.47655671
137HTLV-I infection_Homo sapiens_hsa051660.46546773
138Retinol metabolism_Homo sapiens_hsa008300.46114999
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46105240
140Ras signaling pathway_Homo sapiens_hsa040140.45872837
141Oxytocin signaling pathway_Homo sapiens_hsa049210.45061137
142Staphylococcus aureus infection_Homo sapiens_hsa051500.43955088
143Viral myocarditis_Homo sapiens_hsa054160.42689722
144Arachidonic acid metabolism_Homo sapiens_hsa005900.42301315
145Galactose metabolism_Homo sapiens_hsa000520.42134709
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.40320185
147Graft-versus-host disease_Homo sapiens_hsa053320.39733221
148Phototransduction_Homo sapiens_hsa047440.37997876
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36400623
150Hepatitis C_Homo sapiens_hsa051600.36226218
151Toxoplasmosis_Homo sapiens_hsa051450.35807702
152Notch signaling pathway_Homo sapiens_hsa043300.35087963
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.32980075
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32781264
155Chronic myeloid leukemia_Homo sapiens_hsa052200.32455067
156TNF signaling pathway_Homo sapiens_hsa046680.31843450
157Vitamin B6 metabolism_Homo sapiens_hsa007500.31610854
158MicroRNAs in cancer_Homo sapiens_hsa052060.30752705
159Pertussis_Homo sapiens_hsa051330.30417539
160Carbon metabolism_Homo sapiens_hsa012000.29163422
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28006003
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27247654
163Fatty acid elongation_Homo sapiens_hsa000620.26300814
164Metabolic pathways_Homo sapiens_hsa011000.25412515
165Malaria_Homo sapiens_hsa051440.24614838
166Platelet activation_Homo sapiens_hsa046110.24156330
167Pancreatic cancer_Homo sapiens_hsa052120.23364348

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