SEC63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.43682344
2L-phenylalanine catabolic process (GO:0006559)5.43682344
3L-phenylalanine metabolic process (GO:0006558)5.09078661
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.09078661
5regulation of double-strand break repair via homologous recombination (GO:0010569)4.92001488
6spliceosomal complex assembly (GO:0000245)4.86782161
7regulation of meiosis I (GO:0060631)4.85160077
8aromatic amino acid family catabolic process (GO:0009074)4.78804682
9regulation of DNA damage checkpoint (GO:2000001)4.73597719
10negative regulation of fibrinolysis (GO:0051918)4.57997591
11G1 DNA damage checkpoint (GO:0044783)4.56381762
12alpha-linolenic acid metabolic process (GO:0036109)4.52716474
13mitotic G1 DNA damage checkpoint (GO:0031571)4.52286248
14protein carboxylation (GO:0018214)4.50830719
15peptidyl-glutamic acid carboxylation (GO:0017187)4.50830719
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44264033
17complement activation, alternative pathway (GO:0006957)4.43652046
18negative regulation of DNA-dependent DNA replication (GO:2000104)4.33719122
19regulation of fibrinolysis (GO:0051917)4.28540817
20regulation of protein activation cascade (GO:2000257)4.25765803
21cysteine metabolic process (GO:0006534)4.20394573
22tryptophan catabolic process (GO:0006569)4.19629421
23indole-containing compound catabolic process (GO:0042436)4.19629421
24indolalkylamine catabolic process (GO:0046218)4.19629421
25bile acid biosynthetic process (GO:0006699)4.19594857
26urea cycle (GO:0000050)4.18601753
27urea metabolic process (GO:0019627)4.18601753
28kynurenine metabolic process (GO:0070189)4.15066157
29tryptophan metabolic process (GO:0006568)4.06454357
30regulation of complement activation (GO:0030449)4.05097176
31keratinocyte development (GO:0003334)4.04681664
32high-density lipoprotein particle remodeling (GO:0034375)4.02967249
33sulfur amino acid catabolic process (GO:0000098)4.01086900
34lactate metabolic process (GO:0006089)4.00175761
35mitotic G1/S transition checkpoint (GO:0044819)3.97104324
36homocysteine metabolic process (GO:0050667)3.85025791
37glyoxylate metabolic process (GO:0046487)3.81417668
38telomere maintenance via telomerase (GO:0007004)3.80662708
39reverse cholesterol transport (GO:0043691)3.79036347
40mRNA cleavage (GO:0006379)3.74766227
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73462023
42telomere maintenance via semi-conservative replication (GO:0032201)3.70293569
43nitrogen cycle metabolic process (GO:0071941)3.70077681
44regulation of DNA endoreduplication (GO:0032875)3.68942571
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.67563761
46bile acid metabolic process (GO:0008206)3.65408639
47hemidesmosome assembly (GO:0031581)3.64774855
48lysine catabolic process (GO:0006554)3.64321560
49lysine metabolic process (GO:0006553)3.64321560
50mitotic chromosome condensation (GO:0007076)3.63549239
51negative regulation of fibroblast apoptotic process (GO:2000270)3.62709128
52intra-S DNA damage checkpoint (GO:0031573)3.54198095
53tyrosine metabolic process (GO:0006570)3.53709154
54paraxial mesoderm development (GO:0048339)3.49273699
55positive regulation of fatty acid beta-oxidation (GO:0032000)3.47271232
56telomere maintenance via telomere lengthening (GO:0010833)3.46058166
57triglyceride homeostasis (GO:0070328)3.43001253
58acylglycerol homeostasis (GO:0055090)3.43001253
59protein-lipid complex remodeling (GO:0034368)3.42367686
60macromolecular complex remodeling (GO:0034367)3.42367686
61plasma lipoprotein particle remodeling (GO:0034369)3.42367686
62regulation of triglyceride catabolic process (GO:0010896)3.38682126
63meiotic chromosome segregation (GO:0045132)3.38538176
64telomere maintenance via recombination (GO:0000722)3.37218065
65phospholipid efflux (GO:0033700)3.36060929
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.34570921
67artery development (GO:0060840)3.34430242
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33903512
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.33903512
70regulation of cholesterol homeostasis (GO:2000188)3.33661254
71cellular modified amino acid catabolic process (GO:0042219)3.33273968
72cellular glucuronidation (GO:0052695)3.32627535
73bile acid and bile salt transport (GO:0015721)3.32016478
74aromatic amino acid family metabolic process (GO:0009072)3.31181447
75intestinal cholesterol absorption (GO:0030299)3.30977000
76plasma lipoprotein particle clearance (GO:0034381)3.28925657
77kinetochore organization (GO:0051383)3.28669361
78mitotic sister chromatid cohesion (GO:0007064)3.28155277
79phospholipid homeostasis (GO:0055091)3.26597541
80fibrinolysis (GO:0042730)3.25053942
81negative regulation of sterol transport (GO:0032372)3.24093689
82negative regulation of cholesterol transport (GO:0032375)3.24093689
83cholesterol efflux (GO:0033344)3.21484636
84regulation of double-strand break repair (GO:2000779)3.20729781
85positive regulation of lipid catabolic process (GO:0050996)3.20484767
86mismatch repair (GO:0006298)3.19349830
87lateral sprouting from an epithelium (GO:0060601)3.18920028
88regulation of plasminogen activation (GO:0010755)3.17747684
89serine family amino acid catabolic process (GO:0009071)3.16938367
90cell adhesion mediated by integrin (GO:0033627)3.16830392
91glutamate metabolic process (GO:0006536)3.16781657
92apical protein localization (GO:0045176)3.14983357
93coenzyme catabolic process (GO:0009109)3.13864437
94mitotic recombination (GO:0006312)3.13466752
95outer ear morphogenesis (GO:0042473)3.11756829
96cellular ketone body metabolic process (GO:0046950)3.11568573
97alpha-amino acid catabolic process (GO:1901606)3.10968868
98* renal system development (GO:0072001)3.09089559
99regulation of cholesterol esterification (GO:0010872)3.08114592
100regulation of fatty acid beta-oxidation (GO:0031998)3.07951395
101amino-acid betaine metabolic process (GO:0006577)3.06592131
102COPI coating of Golgi vesicle (GO:0048205)3.06347866
103Golgi transport vesicle coating (GO:0048200)3.06347866
104epoxygenase P450 pathway (GO:0019373)3.06182863
105lipoprotein metabolic process (GO:0042157)3.05492737
106mitotic DNA integrity checkpoint (GO:0044774)3.05482807
107nuclear pore complex assembly (GO:0051292)3.05267041
108nucleotide-excision repair, DNA damage removal (GO:0000718)3.05193747
109DNA excision (GO:0044349)3.05193747
110RNA polyadenylation (GO:0043631)3.03406282
111mRNA polyadenylation (GO:0006378)3.01496554
112radial glial cell differentiation (GO:0060019)2.98952606
113indolalkylamine metabolic process (GO:0006586)2.98114104
114glucuronate metabolic process (GO:0019585)2.94144463
115uronic acid metabolic process (GO:0006063)2.94144463
116mitotic DNA damage checkpoint (GO:0044773)2.92852880
117dicarboxylic acid biosynthetic process (GO:0043650)2.92521155
118drug transmembrane transport (GO:0006855)2.92339737
119benzene-containing compound metabolic process (GO:0042537)2.92069854
120double-strand break repair via homologous recombination (GO:0000724)2.91534987
121complement activation (GO:0006956)2.91124364
122COPII vesicle coating (GO:0048208)2.91025988
123complement activation, classical pathway (GO:0006958)2.90582780
124plasma lipoprotein particle assembly (GO:0034377)2.90253174
125cellular amino acid catabolic process (GO:0009063)2.89363357
126valine metabolic process (GO:0006573)2.88997745
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88686457
128negative regulation of lipase activity (GO:0060192)2.88465960
129recombinational repair (GO:0000725)2.85718565
130drug catabolic process (GO:0042737)2.85135380
131midgut development (GO:0007494)2.84863005
1324-hydroxyproline metabolic process (GO:0019471)2.84607987
133RNA-dependent DNA replication (GO:0006278)2.84092422
134cerebral cortex radially oriented cell migration (GO:0021799)2.83934518
135sterol homeostasis (GO:0055092)2.83687868
136limb bud formation (GO:0060174)2.83457396
137ethanol oxidation (GO:0006069)2.82639867
138histone exchange (GO:0043486)2.82606744
139regulation of keratinocyte proliferation (GO:0010837)2.82283852
140regulation of bile acid biosynthetic process (GO:0070857)2.81485041
141cholesterol homeostasis (GO:0042632)2.81081914
142regulation of cellular senescence (GO:2000772)2.80959139
143response to X-ray (GO:0010165)2.80410470
144negative regulation of protein activation cascade (GO:2000258)2.80172596
145protein-lipid complex assembly (GO:0065005)2.79529266
146acute-phase response (GO:0006953)2.78476593
147chromatin remodeling at centromere (GO:0031055)2.78215162
148protein activation cascade (GO:0072376)2.77522970
149positive regulation of protein autophosphorylation (GO:0031954)2.76334572
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73206922
151cytolysis (GO:0019835)2.72613146
152growth hormone receptor signaling pathway (GO:0060396)2.71735365
153positive regulation of glycolytic process (GO:0045821)2.71391816
154positive regulation of fatty acid oxidation (GO:0046321)2.71172459
155plasma lipoprotein particle organization (GO:0071827)2.71015669
156protein K6-linked ubiquitination (GO:0085020)2.70568725
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70408596
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.69528622
159establishment of monopolar cell polarity (GO:0061162)2.69528622
160female gonad development (GO:0008585)2.68144585
161opsonization (GO:0008228)2.68139126
162short-chain fatty acid metabolic process (GO:0046459)2.66966778
163protein-lipid complex subunit organization (GO:0071825)2.66030013
164asymmetric protein localization (GO:0008105)2.63322674
165DNA strand elongation involved in DNA replication (GO:0006271)2.61735328
166heterochromatin organization (GO:0070828)2.61681492
167CENP-A containing nucleosome assembly (GO:0034080)2.60279031
168anterior/posterior axis specification, embryo (GO:0008595)2.57954876
169DNA double-strand break processing (GO:0000729)2.57716768
170cell proliferation in forebrain (GO:0021846)2.56693930
171nuclear pore organization (GO:0006999)2.55690385
172tongue development (GO:0043586)2.53666780
173sister chromatid segregation (GO:0000819)2.52340797
174DNA strand elongation (GO:0022616)2.46036792
175DNA replication initiation (GO:0006270)2.45204333
176inner ear receptor cell development (GO:0060119)2.45017425
177regulation of centriole replication (GO:0046599)2.44808143
178stem cell division (GO:0017145)2.44364870
179DNA-dependent DNA replication (GO:0006261)2.41975848
180establishment of tissue polarity (GO:0007164)2.40142801
181establishment of planar polarity (GO:0001736)2.40142801
182negative regulation of mRNA metabolic process (GO:1903312)2.36755629
183regulation of cell cycle checkpoint (GO:1901976)2.36261497
184positive regulation of neuroblast proliferation (GO:0002052)2.35260693
185somatic stem cell division (GO:0048103)2.34912809
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.33609059
187histone mRNA metabolic process (GO:0008334)2.33578854
188telomere maintenance (GO:0000723)2.33084641
189embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29847365
190dentate gyrus development (GO:0021542)2.28509268
191regulation of DNA-dependent DNA replication (GO:0090329)2.28025110
192dorsal/ventral axis specification (GO:0009950)2.27867362
193smoothened signaling pathway (GO:0007224)2.27511467
194telomere organization (GO:0032200)2.26695733
195double-strand break repair via nonhomologous end joining (GO:0006303)2.26481610
196non-recombinational repair (GO:0000726)2.26481610
197regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.25574323
198male meiosis I (GO:0007141)2.25192152
199cranial suture morphogenesis (GO:0060363)2.22520577
200mitotic sister chromatid segregation (GO:0000070)2.21371634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.92441778
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.23645252
3LXR_22158963_ChIP-Seq_LIVER_Mouse4.55868412
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.41448195
5E2F7_22180533_ChIP-Seq_HELA_Human4.00236578
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.62144429
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.50221991
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.45448221
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14633672
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.10702139
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64518338
12CLOCK_20551151_ChIP-Seq_293T_Human2.57090037
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51001056
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.34112900
15AR_21909140_ChIP-Seq_LNCAP_Human2.22222147
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18114997
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17494775
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15682994
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09718480
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08850759
21FUS_26573619_Chip-Seq_HEK293_Human2.05893988
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97188023
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93829195
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.91763672
25EWS_26573619_Chip-Seq_HEK293_Human1.91756758
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.85213752
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78728449
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.77607544
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.77292575
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72454583
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69781846
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69364163
33AR_21572438_ChIP-Seq_LNCaP_Human1.68912242
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65063383
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53476629
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.52257502
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51396227
38GBX2_23144817_ChIP-Seq_PC3_Human1.50707044
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50659343
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49312622
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49138347
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49054001
43* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49054001
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49003027
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.48644000
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48012538
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.47839071
48TAF15_26573619_Chip-Seq_HEK293_Human1.46779065
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46615352
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.46495359
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.46229598
52* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46175199
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44944047
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.43925166
55GATA1_22025678_ChIP-Seq_K562_Human1.43727850
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43714349
57* ELK1_19687146_ChIP-ChIP_HELA_Human1.42090640
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37080528
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36872365
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36673466
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36366948
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35664405
63SMAD4_21799915_ChIP-Seq_A2780_Human1.35320415
64P300_19829295_ChIP-Seq_ESCs_Human1.33841843
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33823747
66* EZH2_27294783_Chip-Seq_NPCs_Mouse1.31813795
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30972761
68ZNF274_21170338_ChIP-Seq_K562_Hela1.30120715
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27042240
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.26972588
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26142036
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25678855
73CJUN_26792858_Chip-Seq_BT549_Human1.24377375
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.22609825
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21930826
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21845249
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19987155
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19839780
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19777518
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19733207
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19533329
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19533329
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19533329
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19410007
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18020292
86* CBP_20019798_ChIP-Seq_JUKART_Human1.17520316
87* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17520316
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17127225
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17007321
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16264390
91SOX2_20726797_ChIP-Seq_SW620_Human1.16198389
92* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15606306
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15429464
94CDX2_22108803_ChIP-Seq_LS180_Human1.15280488
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14724249
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14284582
97AR_25329375_ChIP-Seq_VCAP_Human1.13689847
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.13128184
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.12907949
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12887428
101* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12108261
102VDR_22108803_ChIP-Seq_LS180_Human1.11902684
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11769174
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11732039
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11661821
106* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11577546
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11191912
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.10134487
109ER_23166858_ChIP-Seq_MCF-7_Human1.09928992
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08851107
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08765186
112* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08746508
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08465575
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08459609
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07960573
116GATA4_25053715_ChIP-Seq_YYC3_Human1.07603952
117P300_18555785_Chip-Seq_ESCs_Mouse1.07455048
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.06551147
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.06543070
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06144961
121P53_22387025_ChIP-Seq_ESCs_Mouse1.05914809
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04907287
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04878114
124NANOG_16153702_ChIP-ChIP_HESCs_Human1.04827473
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04533187
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03802272
127IRF8_22096565_ChIP-ChIP_GC-B_Human1.03598570
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03413415
129* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02944637
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02890332
131IGF1R_20145208_ChIP-Seq_DFB_Human1.02676980
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.02188603
133TCF4_23295773_ChIP-Seq_U87_Human1.01543068
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00988960
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00714542
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00560682
137JUN_21703547_ChIP-Seq_K562_Human1.00414421
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99976651
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99102834
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97940755
141* STAT3_23295773_ChIP-Seq_U87_Human0.96058741
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96041803
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95918897
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95731256
145GABP_17652178_ChIP-ChIP_JURKAT_Human0.95382237
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95303174
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95117096
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.95058881
149TP63_23658742_ChIP-Seq_EP156T_Human0.94555271
150TP53_16413492_ChIP-PET_HCT116_Human0.94401131
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94067149
152PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93174546
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92781229
154BCAT_22108803_ChIP-Seq_LS180_Human0.91390232
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.91065808
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.91065808
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90873561
158AHR_22903824_ChIP-Seq_MCF-7_Human0.90420362
159TP53_18474530_ChIP-ChIP_U2OS_Human0.89490197
160BRD4_25478319_ChIP-Seq_HGPS_Human0.88459254
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87953528
162SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87123449
163WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86904082
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86882329
165CDX2_20551321_ChIP-Seq_CACO-2_Human0.86789329
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86352402
167* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85914081
168* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84894919
169GATA6_25053715_ChIP-Seq_YYC3_Human0.83889558
170* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83433132
171PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82587321
172KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80990516
173ISL1_27105846_Chip-Seq_CPCs_Mouse0.80906248
174RXR_22108803_ChIP-Seq_LS180_Human0.80527073
175SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80370378
176ARNT_22903824_ChIP-Seq_MCF-7_Human0.79708246
177VDR_24787735_ChIP-Seq_THP-1_Human0.79234652
178RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78080908
179FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76969477
180DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75914922
181FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75781456
182IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75700733
183FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74271266
184PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72375309
185GATA3_24758297_ChIP-Seq_MCF-7_Human0.72314644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.26236874
2MP0005360_urolithiasis5.49372653
3MP0005085_abnormal_gallbladder_physiolo4.98909734
4MP0005365_abnormal_bile_salt4.69855339
5MP0000566_synostosis4.02926316
6MP0003252_abnormal_bile_duct3.79931113
7MP0008875_abnormal_xenobiotic_pharmacok3.35099429
8MP0006292_abnormal_olfactory_placode3.14647892
9MP0002938_white_spotting2.86423786
10MP0003705_abnormal_hypodermis_morpholog2.85615272
11MP0003941_abnormal_skin_development2.83306511
12MP0010329_abnormal_lipoprotein_level2.64717656
13MP0003195_calcinosis2.48177753
14MP0001666_abnormal_nutrient_absorption2.46743327
15MP0008058_abnormal_DNA_repair2.44182921
16MP0008438_abnormal_cutaneous_collagen2.44020105
17MP0003890_abnormal_embryonic-extraembry2.32403254
18MP0010030_abnormal_orbit_morphology2.30453917
19MP0005083_abnormal_biliary_tract2.28753858
20MP0008877_abnormal_DNA_methylation2.28242174
21MP0010094_abnormal_chromosome_stability2.15666438
22MP0002138_abnormal_hepatobiliary_system2.14440131
23MP0003868_abnormal_feces_composition2.12717968
24MP0002396_abnormal_hematopoietic_system2.11108336
25MP0005332_abnormal_amino_acid2.03700737
26MP0003191_abnormal_cellular_cholesterol1.90873792
27MP0003385_abnormal_body_wall1.87723867
28MP0003300_gastrointestinal_ulcer1.87578845
29MP0009840_abnormal_foam_cell1.86651409
30MP0010368_abnormal_lymphatic_system1.84965573
31MP0001188_hyperpigmentation1.82140739
32MP0003937_abnormal_limbs/digits/tail_de1.81026191
33MP0005171_absent_coat_pigmentation1.80472751
34MP0008057_abnormal_DNA_replication1.78296359
35MP0010234_abnormal_vibrissa_follicle1.76433721
36MP0010307_abnormal_tumor_latency1.74576310
37MP0000609_abnormal_liver_physiology1.73599043
38MP0002233_abnormal_nose_morphology1.70250569
39MP0002118_abnormal_lipid_homeostasis1.68181954
40MP0003806_abnormal_nucleotide_metabolis1.66596994
41MP0005220_abnormal_exocrine_pancreas1.63678897
42MP0003755_abnormal_palate_morphology1.60838418
43MP0009053_abnormal_anal_canal1.55807503
44MP0000049_abnormal_middle_ear1.45042149
45MP0003938_abnormal_ear_development1.44315201
46MP0008789_abnormal_olfactory_epithelium1.44190571
47MP0000432_abnormal_head_morphology1.42126498
48MP0004019_abnormal_vitamin_homeostasis1.41494201
49MP0005248_abnormal_Harderian_gland1.40565450
50MP0001293_anophthalmia1.37445216
51MP0002111_abnormal_tail_morphology1.35789884
52MP0009780_abnormal_chondrocyte_physiolo1.34518775
53MP0000428_abnormal_craniofacial_morphol1.34311965
54MP0000778_abnormal_nervous_system1.34055694
55MP0005275_abnormal_skin_tensile1.33707404
56MP0005319_abnormal_enzyme/_coenzyme1.33544936
57MP0006054_spinal_hemorrhage1.32898220
58MP0009250_abnormal_appendicular_skeleto1.32796812
59MP0002249_abnormal_larynx_morphology1.30722774
60MP0004957_abnormal_blastocyst_morpholog1.30673793
61MP0003111_abnormal_nucleus_morphology1.30285851
62MP0002084_abnormal_developmental_patter1.29625254
63MP0009643_abnormal_urine_homeostasis1.29002379
64MP0001177_atelectasis1.28951065
65MP0009384_cardiac_valve_regurgitation1.27725430
66MP0002177_abnormal_outer_ear1.26222764
67MP0002896_abnormal_bone_mineralization1.25211867
68MP0002877_abnormal_melanocyte_morpholog1.22063147
69MP0003121_genomic_imprinting1.21628358
70MP0002282_abnormal_trachea_morphology1.21252847
71MP0009703_decreased_birth_body1.20821401
72MP0000647_abnormal_sebaceous_gland1.20065714
73MP0004272_abnormal_basement_membrane1.19024770
74MP0003935_abnormal_craniofacial_develop1.13454425
75MP0001944_abnormal_pancreas_morphology1.11636658
76MP0003567_abnormal_fetal_cardiomyocyte1.10688565
77MP0005394_taste/olfaction_phenotype1.08576725
78MP0005499_abnormal_olfactory_system1.08576725
79MP0001879_abnormal_lymphatic_vessel1.07367097
80MP0002085_abnormal_embryonic_tissue1.07010177
81MP0002697_abnormal_eye_size1.05877925
82MP0003880_abnormal_central_pattern1.05704747
83MP0008932_abnormal_embryonic_tissue1.05551444
84MP0003942_abnormal_urinary_system1.04026350
85MP0002928_abnormal_bile_duct1.03135487
86MP0002168_other_aberrant_phenotype1.01493509
87MP0002060_abnormal_skin_morphology1.00999682
88MP0002116_abnormal_craniofacial_bone1.00973155
89MP0009697_abnormal_copulation0.99685448
90MP0005503_abnormal_tendon_morphology0.99386742
91MP0003119_abnormal_digestive_system0.99136856
92MP0004133_heterotaxia0.98968077
93MP0000598_abnormal_liver_morphology0.98826468
94MP0003861_abnormal_nervous_system0.98544960
95MP0003303_peritoneal_inflammation0.98203567
96MP0002078_abnormal_glucose_homeostasis0.97834885
97MP0003566_abnormal_cell_adhesion0.97076469
98MP0003123_paternal_imprinting0.96547475
99MP0000631_abnormal_neuroendocrine_gland0.94745365
100MP0001286_abnormal_eye_development0.94097032
101MP0000534_abnormal_ureter_morphology0.93479333
102MP0002932_abnormal_joint_morphology0.93163750
103MP0008995_early_reproductive_senescence0.91725909
104MP0000537_abnormal_urethra_morphology0.91647737
105MP0010352_gastrointestinal_tract_polyps0.91369384
106MP0004043_abnormal_pH_regulation0.90945028
107MP0002295_abnormal_pulmonary_circulatio0.90839080
108MP0001697_abnormal_embryo_size0.90550760
109MP0005058_abnormal_lysosome_morphology0.90260668
110MP0003045_fibrosis0.90030645
111MP0003693_abnormal_embryo_hatching0.89453451
112MP0002184_abnormal_innervation0.88704424
113MP0000383_abnormal_hair_follicle0.88345613
114MP0003690_abnormal_glial_cell0.87103888
115MP0000762_abnormal_tongue_morphology0.87095297
116MP0004130_abnormal_muscle_cell0.86778464
117MP0005584_abnormal_enzyme/coenzyme_acti0.86279931
118MP0000350_abnormal_cell_proliferation0.86182854
119MP0004185_abnormal_adipocyte_glucose0.86128570
120MP0005380_embryogenesis_phenotype0.85906140
121MP0001672_abnormal_embryogenesis/_devel0.85906140
122MP0005187_abnormal_penis_morphology0.85871973
123MP0005197_abnormal_uvea_morphology0.84234627
124MP0001730_embryonic_growth_arrest0.83957155
125MP0005508_abnormal_skeleton_morphology0.83953774
126MP0003950_abnormal_plasma_membrane0.83327560
127MP0003122_maternal_imprinting0.82287466
128MP0005076_abnormal_cell_differentiation0.81976593
129MP0003115_abnormal_respiratory_system0.81864516
130MP0000613_abnormal_salivary_gland0.81525122
131MP0004197_abnormal_fetal_growth/weight/0.80865383
132MP0003279_aneurysm0.80555058
133MP0004264_abnormal_extraembryonic_tissu0.80534730
134MP0005334_abnormal_fat_pad0.79916731
135MP0001340_abnormal_eyelid_morphology0.79881296
136MP0005408_hypopigmentation0.78823433
137MP0002234_abnormal_pharynx_morphology0.77798753
138MP0002088_abnormal_embryonic_growth/wei0.77665364
139MP0003984_embryonic_growth_retardation0.77259814
140MP0002254_reproductive_system_inflammat0.77079586
141MP0000569_abnormal_digit_pigmentation0.76518543
142MP0002693_abnormal_pancreas_physiology0.76312066
143MP0000767_abnormal_smooth_muscle0.76241973
144MP0003943_abnormal_hepatobiliary_system0.76181526
145MP0002092_abnormal_eye_morphology0.76012820
146MP0001186_pigmentation_phenotype0.75279014
147MP0002909_abnormal_adrenal_gland0.74207754
148MP0001756_abnormal_urination0.73568971
149MP0001881_abnormal_mammary_gland0.73564571
150MP0002971_abnormal_brown_adipose0.73295829
151MP0003283_abnormal_digestive_organ0.71319418
152MP0005257_abnormal_intraocular_pressure0.70986662
153MP0005647_abnormal_sex_gland0.70562421
154MP0005666_abnormal_adipose_tissue0.69758653
155MP0005023_abnormal_wound_healing0.69164236
156MP0005084_abnormal_gallbladder_morpholo0.69114304
157MP0010678_abnormal_skin_adnexa0.67972577
158MP0000003_abnormal_adipose_tissue0.67455315
159MP0001243_abnormal_dermal_layer0.67141802
160MP0009642_abnormal_blood_homeostasis0.67016108
161MP0009764_decreased_sensitivity_to0.66919519
162MP0000639_abnormal_adrenal_gland0.65426459
163MP0009672_abnormal_birth_weight0.65385380
164MP0001958_emphysema0.65201412
165MP0000013_abnormal_adipose_tissue0.63877887
166MP0003453_abnormal_keratinocyte_physiol0.63768736
167MP0000249_abnormal_blood_vessel0.62476657
168MP0005375_adipose_tissue_phenotype0.62418762
169MP0001915_intracranial_hemorrhage0.62241642
170MP0001661_extended_life_span0.62189802
171MP0009763_increased_sensitivity_to0.61932761
172MP0005164_abnormal_response_to0.59615162
173MP0002115_abnormal_skeleton_extremities0.58350766
174MP0001299_abnormal_eye_distance/0.58009586
175MP0005636_abnormal_mineral_homeostasis0.57732760
176MP0002136_abnormal_kidney_physiology0.57461902
177MP0000604_amyloidosis0.56838576
178MP0002128_abnormal_blood_circulation0.56127743
179MP0003091_abnormal_cell_migration0.55755821
180MP0001346_abnormal_lacrimal_gland0.55206418
181MP0000579_abnormal_nail_morphology0.53897587
182MP0003959_abnormal_lean_body0.53222063

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)6.45334928
2Deep venous thrombosis (HP:0002625)6.11595600
3Intrahepatic cholestasis (HP:0001406)5.45200393
4Birth length less than 3rd percentile (HP:0003561)5.24762226
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.93197338
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.82291910
7Complement deficiency (HP:0004431)4.72095683
8Xanthomatosis (HP:0000991)4.56815346
9Chromsome breakage (HP:0040012)4.52757952
10Prolonged partial thromboplastin time (HP:0003645)4.35306407
11Abnormality of cochlea (HP:0000375)4.19108498
12Abnormality of the common coagulation pathway (HP:0010990)4.16547034
13Breast hypoplasia (HP:0003187)4.04690327
14Shawl scrotum (HP:0000049)4.03032469
15Breech presentation (HP:0001623)4.02222895
16Hypoplastic labia majora (HP:0000059)4.01775604
17Hypobetalipoproteinemia (HP:0003563)3.94586175
18Abnormality of the intrinsic pathway (HP:0010989)3.78795782
19Progressive cerebellar ataxia (HP:0002073)3.76492004
20Hypoglycemic coma (HP:0001325)3.71901875
21Epidermoid cyst (HP:0200040)3.69130434
22Abnormality of complement system (HP:0005339)3.68270460
23Abnormality of the labia majora (HP:0012881)3.58510369
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.44461271
25Hyperlipoproteinemia (HP:0010980)3.40168900
26Joint hemorrhage (HP:0005261)3.38396396
27Esophageal atresia (HP:0002032)3.30602159
28Myocardial infarction (HP:0001658)3.30337307
29Morphological abnormality of the inner ear (HP:0011390)3.28786690
30Aplasia/Hypoplasia of the sternum (HP:0006714)3.23573332
31Fat malabsorption (HP:0002630)3.20927052
32Gastrointestinal atresia (HP:0002589)3.18352267
33Hypolipoproteinemia (HP:0010981)3.16879038
34Conjugated hyperbilirubinemia (HP:0002908)3.15975717
35Ketosis (HP:0001946)3.11524007
36Hypoglycemic seizures (HP:0002173)3.08457363
37Hypoalphalipoproteinemia (HP:0003233)3.01656166
38Oligodactyly (HP:0012165)3.01613679
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.01181601
40Cutaneous finger syndactyly (HP:0010554)3.00999611
41Facial hemangioma (HP:0000329)2.91160292
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87757881
43Skin nodule (HP:0200036)2.85248629
44Mitral stenosis (HP:0001718)2.83373933
45Aplasia cutis congenita (HP:0001057)2.82684708
46Hyperinsulinemic hypoglycemia (HP:0000825)2.79744652
47Ketoacidosis (HP:0001993)2.77198997
48Hemivertebrae (HP:0002937)2.74879800
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73707365
50Microglossia (HP:0000171)2.67374153
51Hyperglycemia (HP:0003074)2.67223824
52Hyperammonemia (HP:0001987)2.65848542
53Peritonitis (HP:0002586)2.64458330
54Labial hypoplasia (HP:0000066)2.63136906
55Hepatocellular carcinoma (HP:0001402)2.59941834
56Acute lymphatic leukemia (HP:0006721)2.56782575
57Pterygium (HP:0001059)2.56452250
58Premature rupture of membranes (HP:0001788)2.51769335
59Cutaneous syndactyly (HP:0012725)2.49864913
60Hypercholesterolemia (HP:0003124)2.49443963
61Hyperglycinemia (HP:0002154)2.49428843
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49357356
63Hypoplastic female external genitalia (HP:0012815)2.47454208
64Patellar aplasia (HP:0006443)2.46505753
65Abnormality of methionine metabolism (HP:0010901)2.44951861
66Rhabdomyosarcoma (HP:0002859)2.43854510
67Glomerulonephritis (HP:0000099)2.42240731
68Protrusio acetabuli (HP:0003179)2.41678070
69Turricephaly (HP:0000262)2.41257594
70Abnormality of chromosome stability (HP:0003220)2.39932767
71Small hand (HP:0200055)2.36317545
72Rib fusion (HP:0000902)2.34067730
73Nephritis (HP:0000123)2.34043605
74Fragile skin (HP:0001030)2.30079036
75Abnormality of proline metabolism (HP:0010907)2.26559190
76Hydroxyprolinuria (HP:0003080)2.26559190
77Ependymoma (HP:0002888)2.26099714
78Preaxial foot polydactyly (HP:0001841)2.25745021
79Hypochromic microcytic anemia (HP:0004840)2.23984974
80Systemic lupus erythematosus (HP:0002725)2.23543631
81Esophageal varix (HP:0002040)2.22736957
82Abnormality of purine metabolism (HP:0004352)2.21984322
83Aplasia/Hypoplasia of the patella (HP:0006498)2.21393592
84Menorrhagia (HP:0000132)2.21263292
85Triphalangeal thumb (HP:0001199)2.20691750
86Hypoplastic pelvis (HP:0008839)2.20479468
87Abnormality of glycine metabolism (HP:0010895)2.20469602
88Abnormality of serine family amino acid metabolism (HP:0010894)2.20469602
89Symptomatic seizures (HP:0011145)2.20137050
90Abnormality of the labia (HP:0000058)2.18491384
91Hyperglycinuria (HP:0003108)2.18188145
92Cardiovascular calcification (HP:0011915)2.17234191
93Oligodactyly (hands) (HP:0001180)2.17202286
94Intestinal atresia (HP:0011100)2.15133229
95Steatorrhea (HP:0002570)2.14576506
96Bilateral sensorineural hearing impairment (HP:0008619)2.13449473
97Curly hair (HP:0002212)2.13048569
98Lymphangioma (HP:0100764)2.13038377
99Thin ribs (HP:0000883)2.10562254
100Colon cancer (HP:0003003)2.09972378
101Spontaneous abortion (HP:0005268)2.09680343
102Macroorchidism (HP:0000053)2.08930297
103Coronal craniosynostosis (HP:0004440)2.06991674
104Mitral valve prolapse (HP:0001634)2.05767393
105Vascular calcification (HP:0004934)2.05165815
106Hemorrhage of the eye (HP:0011885)2.01267058
107Abnormality of nucleobase metabolism (HP:0010932)2.00787809
108Small intestinal stenosis (HP:0012848)1.99753437
109Duodenal stenosis (HP:0100867)1.99753437
110Abnormality of the duodenum (HP:0002246)1.98957389
111Volvulus (HP:0002580)1.97329601
112Abnormal lung lobation (HP:0002101)1.96650916
113Febrile seizures (HP:0002373)1.93907531
114Astrocytoma (HP:0009592)1.92090851
115Abnormality of the astrocytes (HP:0100707)1.92090851
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91464878
117Short 4th metacarpal (HP:0010044)1.91464878
118Abnormality of endocrine pancreas physiology (HP:0012093)1.91270084
119Abnormality of the pancreatic islet cells (HP:0006476)1.91270084
120Focal segmental glomerulosclerosis (HP:0000097)1.88363275
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86762595
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.85576482
123Cerebral aneurysm (HP:0004944)1.84545673
124Gout (HP:0001997)1.84181005
125Aortic aneurysm (HP:0004942)1.83943373
126Clitoromegaly (HP:0000057)1.83467819
127Late onset (HP:0003584)1.83376187
128Glioma (HP:0009733)1.83070130
129Aortic dissection (HP:0002647)1.82229890
130Cystic hygroma (HP:0000476)1.81746295
131Abnormality of fatty-acid metabolism (HP:0004359)1.81732266
132Atresia of the external auditory canal (HP:0000413)1.81366661
133Long eyelashes (HP:0000527)1.81347533
134Increased mean platelet volume (HP:0011877)1.81345874
135Subacute progressive viral hepatitis (HP:0006572)1.81207498
136Recurrent gram-negative bacterial infections (HP:0005420)1.81146785
137Spastic diplegia (HP:0001264)1.81066934
138Broad metatarsal (HP:0001783)1.80653566
139Enlarged kidneys (HP:0000105)1.80375144
140Hepatoblastoma (HP:0002884)1.79872565
141Abnormal delivery (HP:0001787)1.79541020
142Abnormal cartilage morphology (HP:0002763)1.77931085
143Severe Myopia (HP:0011003)1.76607065
144* Aneurysm (HP:0002617)1.75570634
145Myelomeningocele (HP:0002475)1.75398186
146Sensorimotor neuropathy (HP:0007141)1.75254792
147Milia (HP:0001056)1.74856003
148Shallow orbits (HP:0000586)1.74689950
149Hematochezia (HP:0002573)1.74599940
150Mucopolysacchariduria (HP:0008155)1.74136290
151Urinary glycosaminoglycan excretion (HP:0003541)1.74136290
152Protuberant abdomen (HP:0001538)1.73068366
153Infantile muscular hypotonia (HP:0008947)1.72582312
154Capillary hemangiomas (HP:0005306)1.72073900
155Meckel diverticulum (HP:0002245)1.71225529
156Gingival bleeding (HP:0000225)1.70437676
157Glomerulosclerosis (HP:0000096)1.70162383
158Hypophosphatemic rickets (HP:0004912)1.69429613
159Atrophic scars (HP:0001075)1.68199277
160* Hyperbilirubinemia (HP:0002904)1.67851607
161Ectopia lentis (HP:0001083)1.67583961
162Amyloidosis (HP:0011034)1.66823644
163Neoplasm of striated muscle (HP:0009728)1.66531648
164Abnormality of the phalanges of the hallux (HP:0010057)1.66513805
165Embryonal renal neoplasm (HP:0011794)1.66480309
166Short palpebral fissure (HP:0012745)1.66331434
167Aplasia/Hypoplasia of the breasts (HP:0010311)1.65833512
168Short ribs (HP:0000773)1.63409689
169Morphological abnormality of the middle ear (HP:0008609)1.62664711
170Slender long bone (HP:0003100)1.61590202
171Nephroblastoma (Wilms tumor) (HP:0002667)1.61542411
172Right ventricular cardiomyopathy (HP:0011663)1.61438521
173Long toe (HP:0010511)1.61429295
174Abnormality of chromosome segregation (HP:0002916)1.60952217
175White forelock (HP:0002211)1.60868129
176Natal tooth (HP:0000695)1.60508111
177Disproportionate tall stature (HP:0001519)1.59920630
178Neuroblastoma (HP:0003006)1.59872588
179Primitive neuroectodermal tumor (HP:0030065)1.59872588
180Neuroblastic tumors (HP:0004376)1.59872588
181Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59872588
182Microtia (HP:0008551)1.59412076
183Enlarged penis (HP:0000040)1.58809635
184Adrenal hypoplasia (HP:0000835)1.58792786
185Renal dysplasia (HP:0000110)1.58731783
186Abnormality of pyrimidine metabolism (HP:0004353)1.58394785
187Patchy hypopigmentation of hair (HP:0011365)1.57857373
188Methylmalonic acidemia (HP:0002912)1.57497729
189Abnormality of the aortic arch (HP:0012303)1.56672175
190Aplasia/Hypoplasia of the tongue (HP:0010295)1.56484092
191Papillary thyroid carcinoma (HP:0002895)1.54995019
192Abnormality of the ileum (HP:0001549)1.54331856
193Increased nuchal translucency (HP:0010880)1.53425756
194Neoplasm of the oral cavity (HP:0100649)1.53079389
195Breast aplasia (HP:0100783)1.51885872
196Aplasia involving forearm bones (HP:0009822)1.51710640
197Absent forearm bone (HP:0003953)1.51710640
198Camptodactyly of toe (HP:0001836)1.51115539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.70887621
2LATS13.63048132
3PNCK3.59659827
4ERN13.58786328
5TRIB33.32428297
6SIK13.15528245
7WEE12.98006464
8TAOK32.95340786
9FRK2.90347584
10PKN22.71490760
11TNIK2.58915967
12PDGFRA2.48593778
13INSRR2.38224564
14PTK62.20688254
15FGFR42.17092800
16KSR12.13159204
17MKNK22.11404293
18KSR22.09870411
19PLK42.01722529
20CDC71.98853885
21NEK91.85027913
22MKNK11.82245219
23TTK1.81909985
24FGFR21.78525875
25WNK31.72840457
26NUAK11.63467158
27CAMK1D1.58230300
28MAP3K101.57979756
29PAK61.56906481
30BRSK11.56748835
31CAMK1G1.53105638
32DDR21.49476479
33MAP3K21.49002915
34BCKDK1.44087664
35SGK2231.43024418
36SGK4941.43024418
37RIPK11.42810182
38EPHA31.35385664
39EPHB11.33807300
40JAK11.32131806
41PTK21.31869957
42RAF11.31635360
43PDGFRB1.31449593
44CDK121.31351797
45PLK31.30655981
46STK31.30495901
47MET1.29955066
48EIF2AK31.26860798
49IRAK31.26314262
50CDK61.25041490
51SRPK11.23577840
52ACVR1B1.22260842
53FGFR31.21848064
54ERBB41.19878229
55TGFBR21.19167865
56BMX1.17869238
57BMPR1B1.12524992
58PLK11.11323594
59WNK41.09357880
60STK241.08169253
61ATM1.04819242
62MST1R1.02895591
63ATR1.01827464
64RET1.01643247
65FER0.99368412
66FLT30.98370784
67NEK10.96825079
68TTN0.95867031
69CASK0.91892386
70JAK20.91571530
71ICK0.90448021
72EIF2AK10.89713702
73PAK30.88263518
74PRKCH0.88043826
75TAF10.87685512
76WNK10.86350976
77MTOR0.85998285
78AKT20.85873464
79HIPK20.84998625
80DMPK0.84526090
81TYK20.84387328
82BRAF0.84347685
83PAK20.83681847
84PIK3CG0.82637648
85CSK0.82421074
86DYRK1B0.81846288
87TRIM280.81447367
88MAP3K140.80095819
89NEK20.77862156
90AKT30.77368301
91MAP3K10.76866704
92LRRK20.76792297
93PLK20.76419359
94ERBB20.76329462
95TGFBR10.75969947
96MAP3K70.74529427
97SGK30.73748599
98PRKAA20.73629196
99PRKDC0.72899467
100GSK3A0.72492676
101EPHB20.72185595
102CSNK1E0.71992547
103BMPR20.71604846
104DYRK30.70832245
105IRAK10.66727674
106FGFR10.66348061
107MST40.61790413
108CHEK10.60515162
109GRK10.60087283
110TSSK60.59907016
111MAP4K20.59735888
112BCR0.59602428
113PRKD10.58526554
114PDPK10.58333213
115MAPK110.57738492
116BRD40.57392061
117ERBB30.55924172
118TRPM70.55773676
119STK40.55606777
120IGF1R0.53375182
121NTRK10.52827355
122CHUK0.51763856
123EGFR0.51719124
124CDK20.51360121
125SGK10.51292996
126PIK3CA0.51006277
127PBK0.50835876
128STK390.50788163
129CDK30.50763670
130IRAK20.49458090
131CDK10.49442883
132MAPK150.49037044
133MAP2K10.47051601
134TBK10.47007184
135PTK2B0.46828054
136INSR0.46824361
137MAP3K130.46175109
138CAMKK10.45596413
139FGR0.44891510
140MAP2K40.44660236
141SCYL20.43693179
142STK38L0.43370534
143MINK10.43185359
144AKT10.42253501
145LATS20.41656208
146NLK0.40893028
147PRKD30.40244174
148CHEK20.39966125
149GSK3B0.39518246
150CSNK1A1L0.38862455
151PASK0.38316666
152PRKAA10.37669505
153SGK20.37267272
154CDC42BPA0.35975638
155EIF2AK20.34300146
156MAPK140.34199013
157MAPK130.34063025
158PDK10.33689966
159CSNK1D0.33507927
160ABL10.33423423
161PRKCG0.33328716
162ALK0.32899343
163ABL20.32301286
164PRKCQ0.32091076
165MAP3K30.31996440

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.76230622
2Homologous recombination_Homo sapiens_hsa034404.69465698
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.85790314
4Non-homologous end-joining_Homo sapiens_hsa034503.85010856
5Nitrogen metabolism_Homo sapiens_hsa009103.76016792
6* Protein export_Homo sapiens_hsa030603.69172479
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10027432
8DNA replication_Homo sapiens_hsa030302.75942097
9Complement and coagulation cascades_Homo sapiens_hsa046102.74322382
10Fanconi anemia pathway_Homo sapiens_hsa034602.72866176
11Arginine biosynthesis_Homo sapiens_hsa002202.61470603
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50974382
13Tryptophan metabolism_Homo sapiens_hsa003802.50298567
14Nucleotide excision repair_Homo sapiens_hsa034202.50157726
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.45475198
16Fatty acid degradation_Homo sapiens_hsa000712.20513311
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08418969
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06523174
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89681044
20Caffeine metabolism_Homo sapiens_hsa002321.83528258
21PPAR signaling pathway_Homo sapiens_hsa033201.80075462
22Staphylococcus aureus infection_Homo sapiens_hsa051501.78734214
23Butanoate metabolism_Homo sapiens_hsa006501.78558886
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74854858
25Basal transcription factors_Homo sapiens_hsa030221.70637767
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68844433
27Hedgehog signaling pathway_Homo sapiens_hsa043401.65852285
28Sulfur metabolism_Homo sapiens_hsa009201.63786587
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63405389
30mRNA surveillance pathway_Homo sapiens_hsa030151.62014126
31Cell cycle_Homo sapiens_hsa041101.61250191
32Basal cell carcinoma_Homo sapiens_hsa052171.58570057
33Fatty acid metabolism_Homo sapiens_hsa012121.58506861
34Histidine metabolism_Homo sapiens_hsa003401.58392980
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.55119549
36Chemical carcinogenesis_Homo sapiens_hsa052041.53984767
37Bile secretion_Homo sapiens_hsa049761.51517919
38Peroxisome_Homo sapiens_hsa041461.51132165
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48636729
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44398826
41Selenocompound metabolism_Homo sapiens_hsa004501.40916860
42Propanoate metabolism_Homo sapiens_hsa006401.40615139
43Lysine degradation_Homo sapiens_hsa003101.40053785
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34245108
45Starch and sucrose metabolism_Homo sapiens_hsa005001.31561413
46RNA transport_Homo sapiens_hsa030131.26911790
47Fat digestion and absorption_Homo sapiens_hsa049751.26767036
48beta-Alanine metabolism_Homo sapiens_hsa004101.23185491
49Retinol metabolism_Homo sapiens_hsa008301.22536319
50ABC transporters_Homo sapiens_hsa020101.20415700
51Phenylalanine metabolism_Homo sapiens_hsa003601.17205400
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16223390
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15677716
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15000341
55Tyrosine metabolism_Homo sapiens_hsa003501.04120975
56One carbon pool by folate_Homo sapiens_hsa006701.02610258
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99841095
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.97092803
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94955929
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93996441
61Steroid biosynthesis_Homo sapiens_hsa001000.93519367
62RNA degradation_Homo sapiens_hsa030180.92837288
63Hippo signaling pathway_Homo sapiens_hsa043900.92676530
64Wnt signaling pathway_Homo sapiens_hsa043100.88517693
65Ether lipid metabolism_Homo sapiens_hsa005650.88055830
66Insulin resistance_Homo sapiens_hsa049310.85839147
67* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85625902
68Spliceosome_Homo sapiens_hsa030400.84802038
69TGF-beta signaling pathway_Homo sapiens_hsa043500.84408876
70Linoleic acid metabolism_Homo sapiens_hsa005910.83759098
71Melanogenesis_Homo sapiens_hsa049160.79154533
72MicroRNAs in cancer_Homo sapiens_hsa052060.77063331
73Fatty acid biosynthesis_Homo sapiens_hsa000610.74669674
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74438049
75Melanoma_Homo sapiens_hsa052180.72007120
76Prion diseases_Homo sapiens_hsa050200.67921225
77ECM-receptor interaction_Homo sapiens_hsa045120.65398948
78Vitamin digestion and absorption_Homo sapiens_hsa049770.65188098
79Pyruvate metabolism_Homo sapiens_hsa006200.64565787
80Fatty acid elongation_Homo sapiens_hsa000620.60447767
81Glycerolipid metabolism_Homo sapiens_hsa005610.60110198
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.58511024
83Oocyte meiosis_Homo sapiens_hsa041140.58286682
84p53 signaling pathway_Homo sapiens_hsa041150.57728143
85Cocaine addiction_Homo sapiens_hsa050300.55562508
86Protein digestion and absorption_Homo sapiens_hsa049740.54432243
87Arginine and proline metabolism_Homo sapiens_hsa003300.54265182
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54061879
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53739989
90Amoebiasis_Homo sapiens_hsa051460.53681136
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53580388
92Long-term depression_Homo sapiens_hsa047300.53509794
93Colorectal cancer_Homo sapiens_hsa052100.53132312
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53027059
95Folate biosynthesis_Homo sapiens_hsa007900.53005651
96Axon guidance_Homo sapiens_hsa043600.52432939
97Adherens junction_Homo sapiens_hsa045200.52144848
98Focal adhesion_Homo sapiens_hsa045100.51744293
99Type II diabetes mellitus_Homo sapiens_hsa049300.51689475
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50387355
101Pathways in cancer_Homo sapiens_hsa052000.48785489
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46515101
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.46079521
104N-Glycan biosynthesis_Homo sapiens_hsa005100.45691913
105Thyroid cancer_Homo sapiens_hsa052160.44480672
106Prostate cancer_Homo sapiens_hsa052150.43740770
107RNA polymerase_Homo sapiens_hsa030200.43693525
108Circadian rhythm_Homo sapiens_hsa047100.43679371
109AMPK signaling pathway_Homo sapiens_hsa041520.42793966
110Proteoglycans in cancer_Homo sapiens_hsa052050.42773599
111Thyroid hormone synthesis_Homo sapiens_hsa049180.41141630
112Dorso-ventral axis formation_Homo sapiens_hsa043200.41070566
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40621405
114Phototransduction_Homo sapiens_hsa047440.40572629
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39740684
116Base excision repair_Homo sapiens_hsa034100.39684809
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.39542663
118Bladder cancer_Homo sapiens_hsa052190.39511824
119Glucagon signaling pathway_Homo sapiens_hsa049220.37929635
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37767449
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37537635
122Lysosome_Homo sapiens_hsa041420.34503148
123Prolactin signaling pathway_Homo sapiens_hsa049170.33915288
124Biosynthesis of amino acids_Homo sapiens_hsa012300.33733006
125Carbon metabolism_Homo sapiens_hsa012000.33594257
126Tight junction_Homo sapiens_hsa045300.33096063
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30443731
128Chronic myeloid leukemia_Homo sapiens_hsa052200.29008550
129Insulin signaling pathway_Homo sapiens_hsa049100.26519890
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25506108
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24335781
132Glutathione metabolism_Homo sapiens_hsa004800.24221848
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23422384
134Endometrial cancer_Homo sapiens_hsa052130.23258810
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22191740
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.22138877
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22025342
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21818699
139mTOR signaling pathway_Homo sapiens_hsa041500.21284265
140Small cell lung cancer_Homo sapiens_hsa052220.20860833
141FoxO signaling pathway_Homo sapiens_hsa040680.20748569
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19355686
143Pancreatic cancer_Homo sapiens_hsa052120.18078237
144Ovarian steroidogenesis_Homo sapiens_hsa049130.17948045
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17846245
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16101164
147Hepatitis C_Homo sapiens_hsa051600.15431806
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13956046
149Renin-angiotensin system_Homo sapiens_hsa046140.13817533

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »