SEC23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.56923482
2plasma lipoprotein particle assembly (GO:0034377)4.72305635
3pyrimidine nucleobase catabolic process (GO:0006208)4.71051670
4cell adhesion mediated by integrin (GO:0033627)4.39967635
5nucleobase catabolic process (GO:0046113)4.35004273
6protein-lipid complex assembly (GO:0065005)4.32806915
7intestinal cholesterol absorption (GO:0030299)4.13215729
8COPI coating of Golgi vesicle (GO:0048205)4.00998572
9Golgi transport vesicle coating (GO:0048200)4.00998572
10low-density lipoprotein particle remodeling (GO:0034374)3.88482280
11endodermal cell differentiation (GO:0035987)3.62250862
12regulation of apoptotic cell clearance (GO:2000425)3.54008813
13intestinal absorption (GO:0050892)3.53216584
14endocardial cushion development (GO:0003197)3.47630899
15negative regulation of fibrinolysis (GO:0051918)3.46570698
16skin morphogenesis (GO:0043589)3.44184823
17vocalization behavior (GO:0071625)3.38957112
18* COPII vesicle coating (GO:0048208)3.36618755
19plasma lipoprotein particle organization (GO:0071827)3.34446159
20cellular ketone body metabolic process (GO:0046950)3.34183446
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31906186
22glutamate secretion (GO:0014047)3.26066446
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.23576418
24L-phenylalanine catabolic process (GO:0006559)3.23576418
25retina vasculature morphogenesis in camera-type eye (GO:0061299)3.23177089
26protein-lipid complex subunit organization (GO:0071825)3.21256522
27plasma lipoprotein particle clearance (GO:0034381)3.20964917
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.20625750
29basement membrane organization (GO:0071711)3.19531089
30negative regulation of fatty acid transport (GO:2000192)3.13740885
31regulation of fibrinolysis (GO:0051917)3.11332884
32synaptic vesicle exocytosis (GO:0016079)3.08201045
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.08071145
34L-phenylalanine metabolic process (GO:0006558)3.08071145
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06432173
36regulation of cholesterol homeostasis (GO:2000188)3.03702599
37protein hydroxylation (GO:0018126)3.01990669
38low-density lipoprotein particle clearance (GO:0034383)3.01083037
39blood coagulation, intrinsic pathway (GO:0007597)3.00927789
40regulation of short-term neuronal synaptic plasticity (GO:0048172)2.99765834
41neuron cell-cell adhesion (GO:0007158)2.97479810
42sequestering of extracellular ligand from receptor (GO:0035581)2.97136017
43layer formation in cerebral cortex (GO:0021819)2.96183724
44protein retention in ER lumen (GO:0006621)2.95736839
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92019863
46negative regulation of complement activation (GO:0045916)2.89653111
47lipoprotein metabolic process (GO:0042157)2.89408897
48UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87030473
49alpha-linolenic acid metabolic process (GO:0036109)2.86015406
50peptidyl-proline hydroxylation (GO:0019511)2.85447159
51ketone body metabolic process (GO:1902224)2.85410024
52high-density lipoprotein particle remodeling (GO:0034375)2.84990981
53protein carboxylation (GO:0018214)2.84909212
54peptidyl-glutamic acid carboxylation (GO:0017187)2.84909212
55epoxygenase P450 pathway (GO:0019373)2.81696386
564-hydroxyproline metabolic process (GO:0019471)2.80715209
57neuron recognition (GO:0008038)2.80427730
58negative regulation of lipase activity (GO:0060192)2.80272512
59regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79707472
60proline transport (GO:0015824)2.79075068
61axonal fasciculation (GO:0007413)2.77987479
62protein localization to synapse (GO:0035418)2.77719245
63fibrinolysis (GO:0042730)2.76163847
64synaptic vesicle maturation (GO:0016188)2.75921160
65proline biosynthetic process (GO:0006561)2.75517867
66drug catabolic process (GO:0042737)2.75515471
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74355023
68G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71824079
69regulation of synaptic vesicle exocytosis (GO:2000300)2.71670000
70lysine catabolic process (GO:0006554)2.71164163
71lysine metabolic process (GO:0006553)2.71164163
72positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.70483103
73neurotransmitter secretion (GO:0007269)2.70178349
74bile acid biosynthetic process (GO:0006699)2.68828549
75exploration behavior (GO:0035640)2.68767157
76aromatic amino acid family catabolic process (GO:0009074)2.68355164
77cell proliferation involved in metanephros development (GO:0072203)2.67886618
78coenzyme catabolic process (GO:0009109)2.66720553
79positive regulation of hemostasis (GO:1900048)2.66692818
80positive regulation of blood coagulation (GO:0030194)2.66692818
81paraxial mesoderm development (GO:0048339)2.66613762
82urea metabolic process (GO:0019627)2.66537482
83urea cycle (GO:0000050)2.66537482
84positive regulation of extracellular matrix organization (GO:1903055)2.66114866
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.65613924
86embryonic foregut morphogenesis (GO:0048617)2.65313414
87positive regulation of hormone biosynthetic process (GO:0046886)2.64585864
88gamma-aminobutyric acid transport (GO:0015812)2.64393005
89substrate adhesion-dependent cell spreading (GO:0034446)2.64262499
90cellular glucuronidation (GO:0052695)2.63102864
91regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.62888903
92proline metabolic process (GO:0006560)2.62190536
93regulation of glutamate receptor signaling pathway (GO:1900449)2.61962203
94glyoxylate metabolic process (GO:0046487)2.61317765
95glutamate metabolic process (GO:0006536)2.60829849
96locomotory exploration behavior (GO:0035641)2.60645632
97negative regulation of hemostasis (GO:1900047)2.60361123
98negative regulation of blood coagulation (GO:0030195)2.60361123
99reverse cholesterol transport (GO:0043691)2.59017893
100negative regulation of wound healing (GO:0061045)2.58479502
101positive regulation of synapse maturation (GO:0090129)2.57676068
102regulation of protein activation cascade (GO:2000257)2.56954853
103negative regulation of coagulation (GO:0050819)2.56011897
104midgut development (GO:0007494)2.55583261
105axon extension (GO:0048675)2.55581340
106regulation of cholesterol biosynthetic process (GO:0045540)2.55477537
107glomerular basement membrane development (GO:0032836)2.55203896
108sterol transport (GO:0015918)2.55029807
109cholesterol transport (GO:0030301)2.55029807
110mesenchymal cell proliferation (GO:0010463)2.54537573
111negative regulation of leukocyte chemotaxis (GO:0002689)2.53988922
112nucleotide-sugar biosynthetic process (GO:0009226)2.53309483
113negative regulation of sodium ion transport (GO:0010766)2.52758288
114wound healing, spreading of epidermal cells (GO:0035313)2.52524117
115regulation of synapse structural plasticity (GO:0051823)2.49458073
116positive regulation of coagulation (GO:0050820)2.48890198
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47877418
118regulation of triglyceride catabolic process (GO:0010896)2.47471705
119kynurenine metabolic process (GO:0070189)2.47108775
120positive regulation of osteoblast proliferation (GO:0033690)2.45608470
121positive regulation of collagen biosynthetic process (GO:0032967)2.45515869
122pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45452807
123dendrite morphogenesis (GO:0048813)2.45157179
124response to muscle activity (GO:0014850)2.44345794
125renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.44013582
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.43950331
127negative regulation of protein activation cascade (GO:2000258)2.43925251
128hemidesmosome assembly (GO:0031581)2.43480548
129cell migration in hindbrain (GO:0021535)2.43349678
130triglyceride homeostasis (GO:0070328)2.43318054
131acylglycerol homeostasis (GO:0055090)2.43318054
132desmosome organization (GO:0002934)2.42896115
133regulation of bile acid biosynthetic process (GO:0070857)2.42892155
134cell migration involved in sprouting angiogenesis (GO:0002042)2.42691689
135collagen fibril organization (GO:0030199)2.41339777
136cell proliferation involved in kidney development (GO:0072111)2.41304083
137dicarboxylic acid biosynthetic process (GO:0043650)2.41177926
138regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40653966
139neurotransmitter-gated ion channel clustering (GO:0072578)2.40231955
140cell-substrate junction assembly (GO:0007044)2.39683369
141plasma lipoprotein particle remodeling (GO:0034369)2.38241405
142protein-lipid complex remodeling (GO:0034368)2.38241405
143macromolecular complex remodeling (GO:0034367)2.38241405
144* vesicle coating (GO:0006901)2.38010490
145regulation of complement activation (GO:0030449)2.37551369
146regulation of plasminogen activation (GO:0010755)2.36965133
147regulation of metalloenzyme activity (GO:0048552)2.36141562
148regulation of synaptic vesicle transport (GO:1902803)2.36018718
149uronic acid metabolic process (GO:0006063)2.35716486
150glucuronate metabolic process (GO:0019585)2.35716486
151mesodermal cell differentiation (GO:0048333)2.35633881
152negative regulation of chondrocyte differentiation (GO:0032331)2.35622610
153cholesterol efflux (GO:0033344)2.35601075
154chondrocyte development (GO:0002063)2.32441241
155positive regulation of axon extension (GO:0045773)2.32125558
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.31277904
157tyrosine metabolic process (GO:0006570)2.30702389
158dendritic spine morphogenesis (GO:0060997)2.30104946
159nitrogen cycle metabolic process (GO:0071941)2.29949042
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29595360
161bile acid metabolic process (GO:0008206)2.29129467
162dicarboxylic acid catabolic process (GO:0043649)2.29036259
163regulation of cholesterol esterification (GO:0010872)2.27897559
164chondrocyte proliferation (GO:0035988)2.27745429
165regulation of female receptivity (GO:0045924)2.26326916
166innervation (GO:0060384)2.26224895
167exogenous drug catabolic process (GO:0042738)2.25064739
168positive regulation of fatty acid beta-oxidation (GO:0032000)2.23980261
169positive regulation of lipid catabolic process (GO:0050996)2.23479932
170arginine metabolic process (GO:0006525)2.23201178
171complement activation, alternative pathway (GO:0006957)2.19394928
172cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.19263910
173homocysteine metabolic process (GO:0050667)2.19260346
174neuron projection extension (GO:1990138)2.17839252
175sulfur amino acid catabolic process (GO:0000098)2.17423338
176indole-containing compound catabolic process (GO:0042436)2.17122700
177indolalkylamine catabolic process (GO:0046218)2.17122700
178tryptophan catabolic process (GO:0006569)2.17122700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.32329093
2GBX2_23144817_ChIP-Seq_PC3_Human3.09393052
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.93291023
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89585294
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.78371056
6FOXA2_19822575_ChIP-Seq_HepG2_Human2.55702695
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.50023351
8AR_21909140_ChIP-Seq_LNCAP_Human2.35368233
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32534465
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32460979
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.31305213
12SALL4_18804426_ChIP-ChIP_XEN_Mouse2.30549488
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27043460
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25708212
15CJUN_26792858_Chip-Seq_BT549_Human2.15868682
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08661779
17BRD4_25478319_ChIP-Seq_HGPS_Human2.05542505
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04625523
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04625523
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.04355361
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02898620
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02064138
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.99803751
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.98425691
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97815668
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96992772
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96058132
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94770013
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92942556
30AR_21572438_ChIP-Seq_LNCaP_Human1.89623974
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87194756
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86966700
33TAF15_26573619_Chip-Seq_HEK293_Human1.85806345
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.78669248
35CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77657671
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76872267
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75600827
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.74370487
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72646656
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72360146
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.69387862
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68543084
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67754932
44* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62054724
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60356176
46SMAD4_21799915_ChIP-Seq_A2780_Human1.54844663
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53969686
48REST_21632747_ChIP-Seq_MESCs_Mouse1.53790787
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.50928231
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50760619
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50755345
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.49897998
53* ZNF274_21170338_ChIP-Seq_K562_Hela1.49799756
54* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48704937
55ZNF263_19887448_ChIP-Seq_K562_Human1.47835941
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47510042
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.46565062
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46312718
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45326772
60* P300_19829295_ChIP-Seq_ESCs_Human1.44392203
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43866533
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.42190416
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41835310
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.41669742
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41365804
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39501499
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39432254
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38631347
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38535161
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38535161
71GATA4_25053715_ChIP-Seq_YYC3_Human1.37748436
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37340494
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36933624
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36323771
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35382871
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34991604
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.34696026
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.34353153
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33796448
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33769311
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32233738
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32188153
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.31681642
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29558509
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29057445
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28467813
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28173013
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26743134
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26169449
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25992087
91DROSHA_22980978_ChIP-Seq_HELA_Human1.25450259
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22806331
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22553506
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22553506
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.22355615
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22286036
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21566319
98TP53_18474530_ChIP-ChIP_U2OS_Human1.21181946
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.20993197
100BCAT_22108803_ChIP-Seq_LS180_Human1.20382320
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20370751
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19042578
103* FUS_26573619_Chip-Seq_HEK293_Human1.18072145
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18010162
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17462787
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16841159
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.16196142
108AR_25329375_ChIP-Seq_VCAP_Human1.15399726
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14428622
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.14244876
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12492051
112STAT3_23295773_ChIP-Seq_U87_Human1.12432489
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12306528
114* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11317135
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.11106971
116SOX2_20726797_ChIP-Seq_SW620_Human1.11037792
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09823533
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09649366
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.09378956
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09348360
121CLOCK_20551151_ChIP-Seq_293T_Human1.09073787
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.09004411
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.08751195
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08383487
125JUN_21703547_ChIP-Seq_K562_Human1.05693992
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05625115
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04909036
128VDR_22108803_ChIP-Seq_LS180_Human1.04479310
129AR_19668381_ChIP-Seq_PC3_Human1.04327908
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03280809
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02595184
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02590111
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01969485
134CDX2_20551321_ChIP-Seq_CACO-2_Human1.01969301
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01919134
136* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00664807
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99321681
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.99289276
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97800230
140EOMES_21245162_ChIP-Seq_HESCs_Human0.97649886
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.97362077
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97280118
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95638905
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.95388642
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.95217219
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95209949
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95070899
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.94686266
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94251568
150AHR_22903824_ChIP-Seq_MCF-7_Human0.93564716
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93485171
152CBP_20019798_ChIP-Seq_JUKART_Human0.93485171
153TP53_22127205_ChIP-Seq_IMR90_Human0.92799094
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92666999
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.91615018
156KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91308263
157TCF4_23295773_ChIP-Seq_U87_Human0.90902268
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90559185
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90493574
160* ER_23166858_ChIP-Seq_MCF-7_Human0.90483672
161RUNX2_22187159_ChIP-Seq_PCA_Human0.90025174
162TP53_16413492_ChIP-PET_HCT116_Human0.89045885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.85171727
2MP0002139_abnormal_hepatobiliary_system3.61241517
3MP0003950_abnormal_plasma_membrane3.36118986
4MP0006054_spinal_hemorrhage3.30451256
5MP0004859_abnormal_synaptic_plasticity3.13340801
6MP0005257_abnormal_intraocular_pressure2.82228608
7MP0010368_abnormal_lymphatic_system2.79839237
8MP0005085_abnormal_gallbladder_physiolo2.69641101
9MP0008438_abnormal_cutaneous_collagen2.59357068
10MP0009780_abnormal_chondrocyte_physiolo2.43255705
11MP0003566_abnormal_cell_adhesion2.38702561
12MP0004270_analgesia2.33752182
13MP0005503_abnormal_tendon_morphology2.33015776
14MP0003880_abnormal_central_pattern2.27395596
15MP0008875_abnormal_xenobiotic_pharmacok2.18159696
16MP0002837_dystrophic_cardiac_calcinosis2.15076495
17MP0005365_abnormal_bile_salt2.14649849
18MP0003941_abnormal_skin_development2.14270522
19MP0003635_abnormal_synaptic_transmissio2.07656471
20MP0003705_abnormal_hypodermis_morpholog1.90696618
21MP0002063_abnormal_learning/memory/cond1.84021954
22MP0001958_emphysema1.83277823
23MP0003122_maternal_imprinting1.82627118
24MP0006276_abnormal_autonomic_nervous1.68542584
25MP0003252_abnormal_bile_duct1.66239087
26MP0001915_intracranial_hemorrhage1.62668530
27MP0010329_abnormal_lipoprotein_level1.62603773
28MP0001968_abnormal_touch/_nociception1.62207050
29MP0000767_abnormal_smooth_muscle1.61521661
30MP0003806_abnormal_nucleotide_metabolis1.60286664
31MP0000751_myopathy1.60157579
32MP0002734_abnormal_mechanical_nocicepti1.56122097
33MP0005275_abnormal_skin_tensile1.55707229
34MP0005623_abnormal_meninges_morphology1.55234004
35MP0001661_extended_life_span1.54734527
36MP0009384_cardiac_valve_regurgitation1.53818197
37MP0009745_abnormal_behavioral_response1.53302014
38MP0003329_amyloid_beta_deposits1.52925027
39MP0004858_abnormal_nervous_system1.51177157
40MP0005408_hypopigmentation1.50941024
41MP0002736_abnormal_nociception_after1.50018762
42MP0000778_abnormal_nervous_system1.45404883
43MP0002822_catalepsy1.44348283
44MP0009053_abnormal_anal_canal1.43954204
45MP0009697_abnormal_copulation1.43212836
46MP0002064_seizures1.39787316
47MP0002572_abnormal_emotion/affect_behav1.38945748
48MP0002735_abnormal_chemical_nociception1.34472010
49MP0010030_abnormal_orbit_morphology1.33333465
50MP0005023_abnormal_wound_healing1.32693601
51MP0009840_abnormal_foam_cell1.30989896
52MP0001440_abnormal_grooming_behavior1.27863920
53MP0004272_abnormal_basement_membrane1.24798371
54MP0009046_muscle_twitch1.23841352
55MP0003385_abnormal_body_wall1.23400611
56MP0009250_abnormal_appendicular_skeleto1.22926443
57MP0000013_abnormal_adipose_tissue1.20055650
58MP0002184_abnormal_innervation1.19205745
59MP0004233_abnormal_muscle_weight1.18287103
60MP0000537_abnormal_urethra_morphology1.16895698
61MP0000003_abnormal_adipose_tissue1.15564466
62MP0002282_abnormal_trachea_morphology1.13664896
63MP0003937_abnormal_limbs/digits/tail_de1.12915924
64MP0001177_atelectasis1.12718889
65MP0001299_abnormal_eye_distance/1.12330066
66MP0001666_abnormal_nutrient_absorption1.12033991
67MP0010352_gastrointestinal_tract_polyps1.11966353
68MP0004134_abnormal_chest_morphology1.11604291
69MP0002938_white_spotting1.10680108
70MP0003942_abnormal_urinary_system1.09954154
71MP0000534_abnormal_ureter_morphology1.09321783
72MP0005187_abnormal_penis_morphology1.06743001
73MP0002108_abnormal_muscle_morphology1.05056999
74MP0002089_abnormal_postnatal_growth/wei1.04785236
75MP0005248_abnormal_Harderian_gland1.04275218
76MP0003091_abnormal_cell_migration1.03909506
77MP0002877_abnormal_melanocyte_morpholog1.03717058
78MP0002733_abnormal_thermal_nociception1.02874748
79MP0002909_abnormal_adrenal_gland1.01271216
80MP0005409_darkened_coat_color0.99575033
81MP0002272_abnormal_nervous_system0.98711573
82MP0010386_abnormal_urinary_bladder0.98478247
83MP0002060_abnormal_skin_morphology0.98341638
84MP0000955_abnormal_spinal_cord0.98246912
85MP0004811_abnormal_neuron_physiology0.97777973
86MP0005197_abnormal_uvea_morphology0.97489282
87MP0005386_behavior/neurological_phenoty0.97118193
88MP0004924_abnormal_behavior0.97118193
89MP0005423_abnormal_somatic_nervous0.96118861
90MP0005332_abnormal_amino_acid0.96111501
91MP0002896_abnormal_bone_mineralization0.95667360
92MP0004145_abnormal_muscle_electrophysio0.94774541
93MP0002697_abnormal_eye_size0.94290653
94MP0001486_abnormal_startle_reflex0.93796963
95MP0003123_paternal_imprinting0.91287975
96MP0002128_abnormal_blood_circulation0.91231868
97MP0003868_abnormal_feces_composition0.90024803
98MP0002067_abnormal_sensory_capabilities0.89967520
99MP0002295_abnormal_pulmonary_circulatio0.89592685
100MP0000762_abnormal_tongue_morphology0.89511532
101MP0003279_aneurysm0.89046273
102MP0005508_abnormal_skeleton_morphology0.87194694
103MP0003890_abnormal_embryonic-extraembry0.83963629
104MP0000604_amyloidosis0.83722176
105MP0002557_abnormal_social/conspecific_i0.82192429
106MP0000733_abnormal_muscle_development0.81622153
107MP0002092_abnormal_eye_morphology0.80993677
108MP0005620_abnormal_muscle_contractility0.80907562
109MP0003195_calcinosis0.80432568
110MP0001879_abnormal_lymphatic_vessel0.79773222
111MP0005330_cardiomyopathy0.79482003
112MP0004085_abnormal_heartbeat0.78973134
113MP0000428_abnormal_craniofacial_morphol0.78142792
114MP0005084_abnormal_gallbladder_morpholo0.77831534
115MP0002233_abnormal_nose_morphology0.77045881
116MP0003755_abnormal_palate_morphology0.76544620
117MP0000538_abnormal_urinary_bladder0.76369365
118MP0003119_abnormal_digestive_system0.76284266
119MP0001970_abnormal_pain_threshold0.76074186
120MP0002066_abnormal_motor_capabilities/c0.75710896
121MP0005083_abnormal_biliary_tract0.75462451
122MP0006138_congestive_heart_failure0.75173447
123MP0004130_abnormal_muscle_cell0.74631794
124MP0004036_abnormal_muscle_relaxation0.74478020
125MP0000747_muscle_weakness0.74121983
126MP0001984_abnormal_olfaction0.74069698
127MP0001614_abnormal_blood_vessel0.73836385
128MP0004084_abnormal_cardiac_muscle0.73565663
129MP0008775_abnormal_heart_ventricle0.73101483
130MP0003935_abnormal_craniofacial_develop0.72380492
131MP0003567_abnormal_fetal_cardiomyocyte0.72258716
132MP0002882_abnormal_neuron_morphology0.72030978
133MP0002269_muscular_atrophy0.71939599
134MP0002118_abnormal_lipid_homeostasis0.71858901
135MP0003315_abnormal_perineum_morphology0.71824289
136MP0001501_abnormal_sleep_pattern0.71673428
137MP0005171_absent_coat_pigmentation0.71640264
138MP0003115_abnormal_respiratory_system0.71621529
139MP0000163_abnormal_cartilage_morphology0.71366303
140MP0004215_abnormal_myocardial_fiber0.70912653
141MP0001270_distended_abdomen0.69920617
142MP0001286_abnormal_eye_development0.69628184
143MP0004087_abnormal_muscle_fiber0.68985306
144MP0002876_abnormal_thyroid_physiology0.68714700
145MP0000566_synostosis0.68314477
146MP0002152_abnormal_brain_morphology0.68282615
147MP0002115_abnormal_skeleton_extremities0.67041360
148MP0003646_muscle_fatigue0.66184868
149MP0000749_muscle_degeneration0.65888864
150MP0002925_abnormal_cardiovascular_devel0.65459876
151MP0002086_abnormal_extraembryonic_tissu0.64291525
152MP0002932_abnormal_joint_morphology0.64220227
153MP0002109_abnormal_limb_morphology0.62721192
154MP0002084_abnormal_developmental_patter0.61806886
155MP0005193_abnormal_anterior_eye0.61602275

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)4.14532671
2Aortic aneurysm (HP:0004942)3.75512161
3Hypobetalipoproteinemia (HP:0003563)3.65420037
4Asymmetry of the thorax (HP:0001555)3.61381345
5Vascular tortuosity (HP:0004948)3.56993663
6Protrusio acetabuli (HP:0003179)3.53816556
7Arterial tortuosity (HP:0005116)3.46895142
8Deep venous thrombosis (HP:0002625)3.41498337
9Soft skin (HP:0000977)3.25738622
10Cardiovascular calcification (HP:0011915)3.24235511
11Abnormality of carpal bone ossification (HP:0006257)3.22302465
12Vitreoretinal degeneration (HP:0000655)3.08342864
13Premature rupture of membranes (HP:0001788)2.94410800
14Hepatoblastoma (HP:0002884)2.92354081
15Abnormality of the acetabulum (HP:0003170)2.91077136
16Bladder diverticulum (HP:0000015)2.83289193
17Cupped ribs (HP:0000887)2.81407808
18Joint hemorrhage (HP:0005261)2.77984119
19Xanthomatosis (HP:0000991)2.77639677
20Abnormal delivery (HP:0001787)2.75505329
21Small epiphyses (HP:0010585)2.75356487
22Ankle contracture (HP:0006466)2.75231443
23Wormian bones (HP:0002645)2.74219543
24Follicular hyperkeratosis (HP:0007502)2.73909104
25Intrahepatic cholestasis (HP:0001406)2.73097110
26Vascular calcification (HP:0004934)2.72216837
27Hypolipoproteinemia (HP:0010981)2.71924797
28Atrophic scars (HP:0001075)2.62642550
29Abnormal ossification of hand bones (HP:0005921)2.58881515
30Focal motor seizures (HP:0011153)2.57627252
31Hypercholesterolemia (HP:0003124)2.55845661
32Cervical subluxation (HP:0003308)2.54875121
33Renal duplication (HP:0000075)2.50363760
34Flat acetabular roof (HP:0003180)2.47768463
35Abnormality of the lower motor neuron (HP:0002366)2.47276182
36Abnormal hand bone ossification (HP:0010660)2.44383342
37Flared iliac wings (HP:0002869)2.39219619
38Focal seizures (HP:0007359)2.38932491
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38257987
40Broad palm (HP:0001169)2.38197005
41Epiphyseal dysplasia (HP:0002656)2.37365149
42Pheochromocytoma (HP:0002666)2.36492690
43Hypoplastic ischia (HP:0003175)2.33548858
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33200356
45Acanthocytosis (HP:0001927)2.31596829
46Termporal pattern (HP:0011008)2.31382369
47Insidious onset (HP:0003587)2.31382369
48Abnormality of the ischium (HP:0003174)2.30446855
49Menorrhagia (HP:0000132)2.29802910
50Overgrowth (HP:0001548)2.27417287
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23782519
52Mitral valve prolapse (HP:0001634)2.23379909
53Blue sclerae (HP:0000592)2.23010974
54Hypoalphalipoproteinemia (HP:0003233)2.21857447
55Ovoid vertebral bodies (HP:0003300)2.21655219
56Myokymia (HP:0002411)2.20598175
57Hyperventilation (HP:0002883)2.19596947
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17972243
59Epileptic encephalopathy (HP:0200134)2.16840338
60Vertebral compression fractures (HP:0002953)2.16826337
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14253230
62Coxa vara (HP:0002812)2.13788822
63Conjugated hyperbilirubinemia (HP:0002908)2.12866239
64Broad ribs (HP:0000885)2.12753713
65Hydroxyprolinuria (HP:0003080)2.10797776
66Abnormality of proline metabolism (HP:0010907)2.10797776
67Epidermoid cyst (HP:0200040)2.09260975
68Cerebral aneurysm (HP:0004944)2.08895962
69Abnormal gallbladder physiology (HP:0012438)2.08859955
70Cholecystitis (HP:0001082)2.08859955
71Fragile skin (HP:0001030)2.06550180
72Mild short stature (HP:0003502)2.06522522
73Neuroendocrine neoplasm (HP:0100634)2.06414912
74Biconcave vertebral bodies (HP:0004586)2.05865761
75Atonic seizures (HP:0010819)2.05384117
76Osteoarthritis (HP:0002758)2.04923186
77Irregular epiphyses (HP:0010582)2.04839595
78Prolonged partial thromboplastin time (HP:0003645)2.04765512
79Visual hallucinations (HP:0002367)2.04603074
80Hyperextensible skin (HP:0000974)2.03980546
81Abnormality of the lumbar spine (HP:0100712)2.02530791
82Hemorrhage of the eye (HP:0011885)1.99284313
83Impaired vibration sensation in the lower limbs (HP:0002166)1.98547980
84Neonatal short-limb short stature (HP:0008921)1.98072114
85Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96356329
86Skin nodule (HP:0200036)1.93815101
87Abnormality of dentin (HP:0010299)1.92594207
88Broad alveolar ridges (HP:0000187)1.91152965
89Cerebral inclusion bodies (HP:0100314)1.90704002
90Generalized tonic-clonic seizures (HP:0002069)1.90008184
91Impaired pain sensation (HP:0007328)1.89322711
92Abnormality of pain sensation (HP:0010832)1.89322711
93Torticollis (HP:0000473)1.87732195
94Aneurysm (HP:0002617)1.86824072
95Natal tooth (HP:0000695)1.86687996
96Back pain (HP:0003418)1.84645344
97Abnormality of the corticospinal tract (HP:0002492)1.84451781
98Abnormality of complement system (HP:0005339)1.84039509
99Proximal tubulopathy (HP:0000114)1.83939418
100Absence seizures (HP:0002121)1.83933982
101Abnormality of the common coagulation pathway (HP:0010990)1.82445734
102Elbow flexion contracture (HP:0002987)1.82191324
103Relative macrocephaly (HP:0004482)1.81661660
104Hyperlipoproteinemia (HP:0010980)1.81379452
105Progressive cerebellar ataxia (HP:0002073)1.80569329
106Abnormal foot bone ossification (HP:0010675)1.80408449
107Delayed gross motor development (HP:0002194)1.79630450
108Epileptiform EEG discharges (HP:0011182)1.79561618
109Arthropathy (HP:0003040)1.78810385
110Abnormal tarsal ossification (HP:0008369)1.78446198
111EEG with generalized epileptiform discharges (HP:0011198)1.77511772
112Complement deficiency (HP:0004431)1.76483089
113Myocardial infarction (HP:0001658)1.75887671
114Rhizomelia (HP:0008905)1.75841364
115Excessive salivation (HP:0003781)1.74556938
116Drooling (HP:0002307)1.74556938
117Hypsarrhythmia (HP:0002521)1.73425609
118Fibular hypoplasia (HP:0003038)1.73272085
119Protruding ear (HP:0000411)1.72987660
120Protuberant abdomen (HP:0001538)1.72945685
121Inguinal hernia (HP:0000023)1.71129440
122Shoulder girdle muscle weakness (HP:0003547)1.70708663
123Pterygium (HP:0001059)1.70530396
124Shallow orbits (HP:0000586)1.70443756
125Type 1 muscle fiber predominance (HP:0003803)1.69968666
126Dilatation of the ascending aorta (HP:0005111)1.69179045
127Mildly elevated creatine phosphokinase (HP:0008180)1.68859075
128Spontaneous abortion (HP:0005268)1.68568810
129Hyperglycinemia (HP:0002154)1.68430161
130Peritonitis (HP:0002586)1.66564084
131Morphological abnormality of the pyramidal tract (HP:0002062)1.65506377
132Ulnar bowing (HP:0003031)1.65262724
133Infantile muscular hypotonia (HP:0008947)1.64561715
134Advanced eruption of teeth (HP:0006288)1.64395942
135Neonatal death (HP:0003811)1.64155516
136* Abnormality of the wing of the ilium (HP:0011867)1.63452000
137Craniofacial dystonia (HP:0012179)1.62666994
138Focal dystonia (HP:0004373)1.62384954
139Limb dystonia (HP:0002451)1.62374932
140Neoplasm of the peripheral nervous system (HP:0100007)1.60902206
141Exercise-induced muscle cramps (HP:0003710)1.60816126
142Buphthalmos (HP:0000557)1.60774392
143Striae distensae (HP:0001065)1.60631453
144Disproportionate tall stature (HP:0001519)1.59865449
145Spondylolisthesis (HP:0003302)1.59809876
146Coronal craniosynostosis (HP:0004440)1.59803160
147Mitral regurgitation (HP:0001653)1.59494128
148Urinary urgency (HP:0000012)1.58502555
149* Joint laxity (HP:0001388)1.58351363
150Mitral stenosis (HP:0001718)1.57219997
151Abnormal gallbladder morphology (HP:0012437)1.56556160
152Ketosis (HP:0001946)1.56495512
153Urinary bladder sphincter dysfunction (HP:0002839)1.54853346
154Increased variability in muscle fiber diameter (HP:0003557)1.53739621
155Ectopia lentis (HP:0001083)1.53691697
156Abnormality of the intrinsic pathway (HP:0010989)1.53162541
157Wrist flexion contracture (HP:0001239)1.53022484
158Cholelithiasis (HP:0001081)1.52470530
159Ankle clonus (HP:0011448)1.52446827
160Amyotrophic lateral sclerosis (HP:0007354)1.52212501
161Amblyopia (HP:0000646)1.51852054
162Neoplasm of the adrenal gland (HP:0100631)1.51770732
163Hypoventilation (HP:0002791)1.51387461
164Spinal rigidity (HP:0003306)1.51308268
165Abnormality of glycolysis (HP:0004366)1.51115543
166Increased serum pyruvate (HP:0003542)1.51115543
167Abnormality of the Achilles tendon (HP:0005109)1.50959598
168Metaphyseal cupping (HP:0003021)1.50122383
169Status epilepticus (HP:0002133)1.48257079
170Turricephaly (HP:0000262)1.48241816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.78812733
2FGFR43.27806339
3MAP3K43.14647075
4LATS23.06409010
5NEK92.91094846
6NTRK32.70551736
7WNK42.58909419
8MAP3K92.54510963
9ICK2.37685462
10MAP2K42.28751680
11EPHA42.27267514
12MINK12.26169768
13DDR22.22647342
14FGFR32.22085968
15CASK2.18491654
16PLK22.15301529
17MYLK2.10871749
18KSR11.98055009
19MAP2K71.96132508
20FRK1.95908580
21NTRK11.83087239
22PAK61.76270344
23PDK41.75796272
24PDK31.75796272
25FLT31.70553550
26TGFBR21.65950971
27PAK31.63823275
28PHKG11.63345280
29PHKG21.63345280
30AKT31.55407839
31PAK21.46457441
32CDK121.45989931
33DAPK21.44559524
34EEF2K1.40542559
35BRSK21.39907561
36KSR21.38776331
37ERBB31.37540737
38PRKD31.30278491
39LMTK21.30052353
40NEK11.29212858
41WNK11.28572116
42FER1.27484803
43EPHB21.26312002
44ERBB41.26272387
45LIMK11.25642795
46STK391.24267765
47NTRK21.22477103
48ACVR1B1.21179410
49PDGFRA1.19327305
50NEK21.17239708
51STK38L1.17223085
52MAP3K121.13112280
53PTK2B1.11247645
54MAPK131.10222589
55PRKCG1.08006256
56LATS11.07922180
57PDK21.06844091
58TRPM71.05874909
59STK31.04730389
60TIE11.02907581
61PDGFRB1.02651238
62EPHA21.01741504
63RIPK10.98501238
64MELK0.97479774
65GRK50.97115169
66FGFR20.96915950
67CDK50.95194213
68PNCK0.94461792
69PRKG20.94194142
70RET0.92385369
71PIK3CA0.90723683
72CAMKK10.90456424
73TRIB30.87675941
74CAMK2A0.87246176
75PRKAA20.85130128
76MAP2K10.84469921
77EIF2AK10.83851135
78TTN0.82712316
79PAK40.82522029
80CDK140.81796519
81DYRK20.80837345
82CSNK1G20.80653449
83BCR0.80441336
84NME10.78449133
85CDK180.77175148
86SCYL20.76686523
87ARAF0.76269614
88CDK80.75831349
89FGFR10.74598226
90PBK0.73790181
91DYRK1B0.72591337
92CDK150.72301948
93PTK20.70053900
94ROCK10.66955634
95MAPKAPK30.66569013
96TESK10.66328465
97BRSK10.65941423
98SGK2230.65404421
99SGK4940.65404421
100MAPK110.65231865
101SGK20.61844006
102MAPKAPK50.61722576
103PRKCZ0.61389197
104PLK30.61145475
105PRKCE0.60488262
106DYRK1A0.60370860
107OBSCN0.58870032
108TYRO30.58792592
109PKN20.58358641
110BMPR1B0.56856821
111SIK10.55621948
112CDK11A0.55490823
113MET0.52714959
114STK380.51769211
115DAPK10.51444683
116EIF2AK30.51121396
117MAP3K20.49673986
118ADRBK10.49304703
119CDK60.49154562
120CDK70.48591049
121EPHA30.48026532
122CDC42BPA0.47957559
123CAMK2B0.47547036
124TTK0.46001202
125MAPK120.45326734
126TAF10.45078203
127MTOR0.43511052
128SGK30.43356486
129CAMK2G0.43274625
130RPS6KB10.43212851
131ROCK20.43146642
132CAMK1G0.43093663
133BRAF0.42831642
134PIK3CG0.42823754
135CSNK1G30.40714970
136ABL20.40246341
137ERBB20.40030280
138CAMK2D0.39762208
139STK240.39688217
140CAMKK20.37922666
141MAP3K50.37654864
142PRKAA10.37238534
143MST1R0.37189838
144WNK30.36299279
145PTK60.35721802
146GSK3A0.34582845
147SGK10.34358710
148BRD40.32789223
149MAP3K60.32092524
150MOS0.30932300
151WEE10.29561947
152PDPK10.29128836
153IRAK30.28798103
154SRC0.28170469

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73891065
2Nitrogen metabolism_Homo sapiens_hsa009102.59673544
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.56642211
4Arginine biosynthesis_Homo sapiens_hsa002202.37361814
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16980596
6Butanoate metabolism_Homo sapiens_hsa006502.09966240
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97695154
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85766324
9Nicotine addiction_Homo sapiens_hsa050331.85617409
10Fatty acid biosynthesis_Homo sapiens_hsa000611.83086355
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81737036
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81228168
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78703832
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68845116
15Synaptic vesicle cycle_Homo sapiens_hsa047211.68258511
16* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50623886
17Pyruvate metabolism_Homo sapiens_hsa006201.49951312
18Tryptophan metabolism_Homo sapiens_hsa003801.49344029
19Bile secretion_Homo sapiens_hsa049761.47703838
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.47278127
21Vitamin digestion and absorption_Homo sapiens_hsa049771.45527926
22N-Glycan biosynthesis_Homo sapiens_hsa005101.44365082
23Complement and coagulation cascades_Homo sapiens_hsa046101.42289065
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40995713
25Fatty acid degradation_Homo sapiens_hsa000711.38972625
26GABAergic synapse_Homo sapiens_hsa047271.36520490
27Renin-angiotensin system_Homo sapiens_hsa046141.30442127
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28310194
29Propanoate metabolism_Homo sapiens_hsa006401.21858072
30Starch and sucrose metabolism_Homo sapiens_hsa005001.19201485
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18866017
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18765917
33Fatty acid metabolism_Homo sapiens_hsa012121.17637043
34Amphetamine addiction_Homo sapiens_hsa050311.17596863
35PPAR signaling pathway_Homo sapiens_hsa033201.16566767
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16515277
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16016269
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15803174
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15426235
40Adherens junction_Homo sapiens_hsa045201.15413074
41Proteoglycans in cancer_Homo sapiens_hsa052051.14924659
42Circadian entrainment_Homo sapiens_hsa047131.14187742
43Sulfur metabolism_Homo sapiens_hsa009201.12994481
44Long-term potentiation_Homo sapiens_hsa047201.09472905
45Dopaminergic synapse_Homo sapiens_hsa047281.09456961
46Hippo signaling pathway_Homo sapiens_hsa043901.08970179
47TGF-beta signaling pathway_Homo sapiens_hsa043501.08225466
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08015150
49Fat digestion and absorption_Homo sapiens_hsa049751.06189359
50Small cell lung cancer_Homo sapiens_hsa052221.06119757
51Carbon metabolism_Homo sapiens_hsa012001.02310571
52Biosynthesis of amino acids_Homo sapiens_hsa012301.01303794
53Olfactory transduction_Homo sapiens_hsa047400.97867367
54Vitamin B6 metabolism_Homo sapiens_hsa007500.97486819
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96602655
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94697909
57Glutamatergic synapse_Homo sapiens_hsa047240.91137108
58Axon guidance_Homo sapiens_hsa043600.90804447
59ABC transporters_Homo sapiens_hsa020100.89981482
60Insulin secretion_Homo sapiens_hsa049110.87639857
61Renin secretion_Homo sapiens_hsa049240.87109336
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86021616
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.83967364
64Phenylalanine metabolism_Homo sapiens_hsa003600.83818961
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.83721527
66Long-term depression_Homo sapiens_hsa047300.83314084
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83260907
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82827435
69Peroxisome_Homo sapiens_hsa041460.82328079
70Gap junction_Homo sapiens_hsa045400.82310327
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80215362
72Lysine degradation_Homo sapiens_hsa003100.79732195
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79643943
74Chemical carcinogenesis_Homo sapiens_hsa052040.79453374
75Morphine addiction_Homo sapiens_hsa050320.79261798
76Glucagon signaling pathway_Homo sapiens_hsa049220.78320122
77Cocaine addiction_Homo sapiens_hsa050300.77007801
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76120104
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75721499
80Sphingolipid metabolism_Homo sapiens_hsa006000.75653664
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75207503
82Oxytocin signaling pathway_Homo sapiens_hsa049210.73905405
83Fructose and mannose metabolism_Homo sapiens_hsa000510.73410116
84Cholinergic synapse_Homo sapiens_hsa047250.72671570
85Dilated cardiomyopathy_Homo sapiens_hsa054140.72506206
86Steroid biosynthesis_Homo sapiens_hsa001000.72485568
87Tyrosine metabolism_Homo sapiens_hsa003500.72083127
88Salivary secretion_Homo sapiens_hsa049700.71902402
89One carbon pool by folate_Homo sapiens_hsa006700.70863266
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70734944
91Protein digestion and absorption_Homo sapiens_hsa049740.67746055
92Amoebiasis_Homo sapiens_hsa051460.66765545
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.66349123
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66089656
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66003784
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65215092
97ECM-receptor interaction_Homo sapiens_hsa045120.65170059
98Caffeine metabolism_Homo sapiens_hsa002320.64578550
99Prion diseases_Homo sapiens_hsa050200.64445759
100Serotonergic synapse_Homo sapiens_hsa047260.63159239
101beta-Alanine metabolism_Homo sapiens_hsa004100.63009578
102Cardiac muscle contraction_Homo sapiens_hsa042600.62861958
103Mineral absorption_Homo sapiens_hsa049780.62302900
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.62124299
105Vibrio cholerae infection_Homo sapiens_hsa051100.61438018
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61158753
107Arginine and proline metabolism_Homo sapiens_hsa003300.60468678
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60240036
109Retinol metabolism_Homo sapiens_hsa008300.59423780
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59304830
111GnRH signaling pathway_Homo sapiens_hsa049120.59171796
112Melanogenesis_Homo sapiens_hsa049160.58783864
113Glycerolipid metabolism_Homo sapiens_hsa005610.58530888
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.58078362
115Taste transduction_Homo sapiens_hsa047420.57999301
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57715802
117Glioma_Homo sapiens_hsa052140.57602173
118Basal cell carcinoma_Homo sapiens_hsa052170.57518704
119Gastric acid secretion_Homo sapiens_hsa049710.56641923
120Fatty acid elongation_Homo sapiens_hsa000620.56360904
121Other glycan degradation_Homo sapiens_hsa005110.56020092
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55762604
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55456037
124Estrogen signaling pathway_Homo sapiens_hsa049150.54086621
125Bladder cancer_Homo sapiens_hsa052190.53929940
126Galactose metabolism_Homo sapiens_hsa000520.53435867
127Histidine metabolism_Homo sapiens_hsa003400.52626650
128Calcium signaling pathway_Homo sapiens_hsa040200.50728560
129Type II diabetes mellitus_Homo sapiens_hsa049300.50697794
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.50222027
131Thyroid hormone synthesis_Homo sapiens_hsa049180.49962192
132Tight junction_Homo sapiens_hsa045300.49950402
133AMPK signaling pathway_Homo sapiens_hsa041520.47027423
134ErbB signaling pathway_Homo sapiens_hsa040120.46609567
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46607058
136Insulin signaling pathway_Homo sapiens_hsa049100.45987103
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45465511
138Focal adhesion_Homo sapiens_hsa045100.45038030
139Pentose phosphate pathway_Homo sapiens_hsa000300.44611301
140Circadian rhythm_Homo sapiens_hsa047100.44196144
141MicroRNAs in cancer_Homo sapiens_hsa052060.43983076
142Selenocompound metabolism_Homo sapiens_hsa004500.42509476
143Hedgehog signaling pathway_Homo sapiens_hsa043400.41477178

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