SEC22C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59177917
2vocalization behavior (GO:0071625)5.18593996
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01547525
4neuron cell-cell adhesion (GO:0007158)4.91908490
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85410955
6locomotory exploration behavior (GO:0035641)4.82413331
7regulation of glutamate receptor signaling pathway (GO:1900449)4.69680805
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66539140
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.63144094
10synaptic vesicle maturation (GO:0016188)4.61567351
11protein localization to synapse (GO:0035418)4.51578109
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.42301162
13positive regulation of mitochondrial fission (GO:0090141)4.34069918
14regulation of synaptic vesicle exocytosis (GO:2000300)4.29098096
15glutamate secretion (GO:0014047)4.24470743
16synaptic vesicle exocytosis (GO:0016079)4.21311184
17neurotransmitter-gated ion channel clustering (GO:0072578)4.12682695
18melanin biosynthetic process (GO:0042438)4.08572218
19regulation of synaptic vesicle transport (GO:1902803)3.98988664
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.97721198
21glutamate receptor signaling pathway (GO:0007215)3.89782420
22proline transport (GO:0015824)3.82796195
23postsynaptic membrane organization (GO:0001941)3.82243663
24secondary metabolite biosynthetic process (GO:0044550)3.78723322
25neurotransmitter secretion (GO:0007269)3.78077287
26synaptic transmission, glutamatergic (GO:0035249)3.77120448
27exploration behavior (GO:0035640)3.73888576
28long-term memory (GO:0007616)3.73740114
29layer formation in cerebral cortex (GO:0021819)3.70739278
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66043130
31gamma-aminobutyric acid transport (GO:0015812)3.65724112
32neuron-neuron synaptic transmission (GO:0007270)3.61760435
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60713080
34cullin deneddylation (GO:0010388)3.60101940
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59654242
36melanin metabolic process (GO:0006582)3.58026303
37regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.57924309
38iron ion import (GO:0097286)3.57763710
39regulation of neuronal synaptic plasticity (GO:0048168)3.56426470
40presynaptic membrane assembly (GO:0097105)3.55094920
41response to histamine (GO:0034776)3.48709734
42transmission of nerve impulse (GO:0019226)3.43896965
43protein K6-linked ubiquitination (GO:0085020)3.43367051
44neuron recognition (GO:0008038)3.42333431
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38007948
46protein K11-linked deubiquitination (GO:0035871)3.35741958
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34881897
48dendritic spine morphogenesis (GO:0060997)3.31334927
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.29127761
50synapse assembly (GO:0007416)3.27319540
51positive regulation of membrane potential (GO:0045838)3.25431151
52neurotransmitter transport (GO:0006836)3.25278245
53protein deneddylation (GO:0000338)3.25069532
54regulation of postsynaptic membrane potential (GO:0060078)3.24049178
55central nervous system projection neuron axonogenesis (GO:0021952)3.23829977
56cerebellar Purkinje cell differentiation (GO:0021702)3.23397601
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21191866
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.20973271
59startle response (GO:0001964)3.19015687
60response to auditory stimulus (GO:0010996)3.17571041
61long-term synaptic potentiation (GO:0060291)3.17347750
62regulation of synapse structural plasticity (GO:0051823)3.16133052
63synaptic vesicle endocytosis (GO:0048488)3.15727044
64positive regulation of neurotransmitter secretion (GO:0001956)3.12802913
65auditory behavior (GO:0031223)3.12555189
66cellular potassium ion homeostasis (GO:0030007)3.12512958
67regulation of neurotransmitter secretion (GO:0046928)3.11831079
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11234332
69dendrite morphogenesis (GO:0048813)3.10306185
70presynaptic membrane organization (GO:0097090)3.08964065
71pyrimidine nucleobase catabolic process (GO:0006208)3.08846007
72endosome to pigment granule transport (GO:0043485)3.06949260
73endosome to melanosome transport (GO:0035646)3.06949260
74dopamine receptor signaling pathway (GO:0007212)3.06585694
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06050426
76innervation (GO:0060384)3.02541887
77resolution of meiotic recombination intermediates (GO:0000712)3.02377510
78signal peptide processing (GO:0006465)3.00150209
79regulation of hexokinase activity (GO:1903299)2.97848708
80regulation of glucokinase activity (GO:0033131)2.97848708
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97772149
82regulation of synaptic plasticity (GO:0048167)2.97171539
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97153791
84axonal fasciculation (GO:0007413)2.96941834
85glycine transport (GO:0015816)2.96703766
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95343112
87neuronal action potential propagation (GO:0019227)2.94277388
88preassembly of GPI anchor in ER membrane (GO:0016254)2.93253877
89regulation of neurotransmitter transport (GO:0051588)2.92636785
90regulation of synaptic transmission, GABAergic (GO:0032228)2.92168757
91membrane hyperpolarization (GO:0060081)2.91802744
92inositol phosphate catabolic process (GO:0071545)2.90382208
93regulation of vesicle fusion (GO:0031338)2.89932800
94positive regulation of neurotransmitter transport (GO:0051590)2.89365623
95platelet dense granule organization (GO:0060155)2.89091386
96regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.89049098
97activation of protein kinase A activity (GO:0034199)2.87955811
98Golgi to endosome transport (GO:0006895)2.87668142
99intraspecies interaction between organisms (GO:0051703)2.85983930
100social behavior (GO:0035176)2.85983930
101regulation of neurotransmitter levels (GO:0001505)2.84857401
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84854407
103kinetochore assembly (GO:0051382)2.84274475
104righting reflex (GO:0060013)2.83218461
105nucleobase catabolic process (GO:0046113)2.83185352
106COPII vesicle coating (GO:0048208)2.82844389
107positive regulation of synapse maturation (GO:0090129)2.82648574
108regulation of Rac protein signal transduction (GO:0035020)2.80980136
109positive regulation of synaptic transmission (GO:0050806)2.80604348
110piRNA metabolic process (GO:0034587)2.80560093
111regulation of integrin-mediated signaling pathway (GO:2001044)2.80097014
112macroautophagy (GO:0016236)2.79687805
113learning (GO:0007612)2.78521334
114pigment cell differentiation (GO:0050931)2.77750368
115mechanosensory behavior (GO:0007638)2.76694873
116regulation of female receptivity (GO:0045924)2.76657665
117kinetochore organization (GO:0051383)2.75871944
118negative regulation of sodium ion transport (GO:0010766)2.75387423
119behavioral fear response (GO:0001662)2.74684979
120behavioral defense response (GO:0002209)2.74684979
121regulation of protein glycosylation (GO:0060049)2.73918761
122anterograde synaptic vesicle transport (GO:0048490)2.73509348
123membrane depolarization (GO:0051899)2.73206477
124response to pheromone (GO:0019236)2.70587937
125retinal cone cell development (GO:0046549)2.69689010
126neuronal ion channel clustering (GO:0045161)2.68597316
127cell migration in hindbrain (GO:0021535)2.68536951
128cerebral cortex radially oriented cell migration (GO:0021799)2.67612219
129opioid receptor signaling pathway (GO:0038003)2.67538773
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67251361
131negative regulation of cell killing (GO:0031342)2.67251361
132synapsis (GO:0007129)2.66204140
133ribonucleoprotein complex disassembly (GO:0032988)2.66001460
134regulation of mitochondrial fission (GO:0090140)2.64256399
135melanosome transport (GO:0032402)2.63670833
136melanosome localization (GO:0032400)2.63537163
137melanocyte differentiation (GO:0030318)2.60852713
138type B pancreatic cell proliferation (GO:0044342)2.59976363
139pigment granule localization (GO:0051875)2.59945632
140pigment granule transport (GO:0051904)2.59583471
141retinal rod cell development (GO:0046548)2.56985311
142mitotic spindle organization (GO:0007052)2.56000267
143C-terminal protein lipidation (GO:0006501)2.54044940
144lipid particle organization (GO:0034389)2.53808743
145establishment of melanosome localization (GO:0032401)2.53334112
146mitochondrial fission (GO:0000266)2.51433533
147establishment of pigment granule localization (GO:0051905)2.49873885
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45488429
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45468554
150inositol phosphate dephosphorylation (GO:0046855)2.45468554
151anterograde axon cargo transport (GO:0008089)2.45106307
152glucosamine-containing compound catabolic process (GO:1901072)2.44935783
153COPI coating of Golgi vesicle (GO:0048205)2.43558194
154Golgi transport vesicle coating (GO:0048200)2.43558194
155melanosome organization (GO:0032438)2.42375811
156* ER to Golgi vesicle-mediated transport (GO:0006888)2.41623348
157negative regulation of neurotransmitter transport (GO:0051589)2.40162064
158peptidyl-cysteine modification (GO:0018198)2.39530232
159meiotic chromosome segregation (GO:0045132)2.39242627
160intraciliary transport (GO:0042073)2.38779227
161regulation of cofactor metabolic process (GO:0051193)2.36708617
162regulation of coenzyme metabolic process (GO:0051196)2.36708617
163alanine transport (GO:0032328)2.35361917
164glycerophospholipid catabolic process (GO:0046475)2.34195250
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.33487318
166neurotransmitter uptake (GO:0001504)2.32952060
167regulation of acyl-CoA biosynthetic process (GO:0050812)2.32869017
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.30303510
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.30303510
170protoporphyrinogen IX metabolic process (GO:0046501)2.29926616
171cilium morphogenesis (GO:0060271)2.29103422
172C-terminal protein amino acid modification (GO:0018410)2.27949795
173organelle disassembly (GO:1903008)2.25287102
174ganglion development (GO:0061548)2.24846381
175mannosylation (GO:0097502)2.23336835
176positive regulation of actin filament depolymerization (GO:0030836)2.23323734
177GPI anchor metabolic process (GO:0006505)2.23242581
178pigment granule organization (GO:0048753)2.22359694
179polyol catabolic process (GO:0046174)2.22262736
180UDP-N-acetylglucosamine metabolic process (GO:0006047)2.20279894
181protoporphyrinogen IX biosynthetic process (GO:0006782)2.20032480
182glial cell proliferation (GO:0014009)2.18852734
183protein targeting to lysosome (GO:0006622)2.18351648
184establishment of protein localization to vacuole (GO:0072666)2.18351648
185protein targeting to vacuole (GO:0006623)2.18351648
186response to lipoprotein particle (GO:0055094)2.17317188
187regulation of centriole replication (GO:0046599)2.15469204
188axon cargo transport (GO:0008088)2.15466094
189GPI anchor biosynthetic process (GO:0006506)2.15337368
190spindle assembly involved in mitosis (GO:0090307)2.15190957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40949646
2GBX2_23144817_ChIP-Seq_PC3_Human3.71978600
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.43157734
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74327825
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68385221
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66826608
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50430428
8REST_21632747_ChIP-Seq_MESCs_Mouse2.49273237
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47991155
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33049300
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.28084703
12DROSHA_22980978_ChIP-Seq_HELA_Human2.27888539
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27761267
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26844257
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22189050
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22179727
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22179727
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22153286
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20705618
20ELK1_19687146_ChIP-ChIP_HELA_Human2.12396409
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11305592
22FUS_26573619_Chip-Seq_HEK293_Human2.10432398
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10192716
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01959397
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.01278637
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.98806637
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97845163
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97121650
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.96612088
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95548216
31EWS_26573619_Chip-Seq_HEK293_Human1.95455267
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.92656242
33VDR_22108803_ChIP-Seq_LS180_Human1.92586662
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.89702529
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.87347434
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77760110
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.76907738
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75010618
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73459163
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.72858829
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72712476
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72442896
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71418290
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.69082096
45AR_21572438_ChIP-Seq_LNCaP_Human1.68651946
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68244331
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67774004
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67300754
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66608338
50TAF15_26573619_Chip-Seq_HEK293_Human1.66021219
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64813496
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.64221989
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.64123654
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60522349
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59518750
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58104344
57IGF1R_20145208_ChIP-Seq_DFB_Human1.57910253
58P300_19829295_ChIP-Seq_ESCs_Human1.57096968
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.56470904
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54817476
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54542861
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54338629
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51196777
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44753688
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.44469214
66AR_21909140_ChIP-Seq_LNCAP_Human1.42202611
67STAT3_23295773_ChIP-Seq_U87_Human1.41829880
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41533198
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.39133111
70IRF1_19129219_ChIP-ChIP_H3396_Human1.38891800
71GATA1_22025678_ChIP-Seq_K562_Human1.38415534
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36008990
73BRD4_25478319_ChIP-Seq_HGPS_Human1.34506793
74RNF2_27304074_Chip-Seq_NSC_Mouse1.33524241
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.32851691
76* VDR_23849224_ChIP-Seq_CD4+_Human1.31788898
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31599399
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30998502
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30188106
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29960632
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29403256
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.28985404
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28474487
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28474487
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27980736
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25818586
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25595045
88TFEB_21752829_ChIP-Seq_HELA_Human1.25419475
89AR_19668381_ChIP-Seq_PC3_Human1.24803980
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.24478352
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24091493
92TCF4_23295773_ChIP-Seq_U87_Human1.23009432
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22695627
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21969554
95* AR_25329375_ChIP-Seq_VCAP_Human1.18996043
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18925129
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17802807
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.16331337
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16236195
100SOX9_26525672_Chip-Seq_HEART_Mouse1.16048290
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16047365
102JUN_21703547_ChIP-Seq_K562_Human1.15156715
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.14393232
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14227409
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14016347
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14016347
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.12819589
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12674445
109* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10759588
110AHR_22903824_ChIP-Seq_MCF-7_Human1.10476437
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10330452
112ER_23166858_ChIP-Seq_MCF-7_Human1.09541078
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08060246
114CDX2_22108803_ChIP-Seq_LS180_Human1.07921477
115CBP_20019798_ChIP-Seq_JUKART_Human1.07646645
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07646645
117* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07246161
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.06364840
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06314016
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.06262706
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05847241
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05625851
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04635230
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.04071929
125TP53_16413492_ChIP-PET_HCT116_Human1.03814017
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03790649
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03748778
128RUNX2_22187159_ChIP-Seq_PCA_Human1.03617084
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03407399
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02575366
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02094716
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.02063855
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.02044150
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02016914
135P53_22387025_ChIP-Seq_ESCs_Mouse1.01872494
136ERG_21242973_ChIP-ChIP_JURKAT_Human1.01237965
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00989455
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.00125353
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00062888
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99717187
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.99652582
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.99216500
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98865661
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98445294
145KDM2B_26808549_Chip-Seq_REH_Human0.97876598
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97227580
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96745621
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.95903542
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95860988
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95530252
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95217902
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95100339
153ZNF274_21170338_ChIP-Seq_K562_Hela0.92052407
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.91005264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25110657
2MP0000372_irregular_coat_pigmentation4.60488641
3MP0003880_abnormal_central_pattern4.09918315
4MP0003635_abnormal_synaptic_transmissio3.64958118
5MP0009745_abnormal_behavioral_response3.17769497
6MP0006054_spinal_hemorrhage3.14980243
7MP0004270_analgesia3.08190473
8MP0005423_abnormal_somatic_nervous3.04784042
9MP0002063_abnormal_learning/memory/cond3.02591677
10MP0002877_abnormal_melanocyte_morpholog2.97219503
11MP0001968_abnormal_touch/_nociception2.92513028
12MP0002735_abnormal_chemical_nociception2.90462555
13MP0003136_yellow_coat_color2.89216651
14MP0004147_increased_porphyrin_level2.87423873
15MP0002064_seizures2.75700796
16MP0002822_catalepsy2.71198088
17MP0001486_abnormal_startle_reflex2.66702997
18MP0002572_abnormal_emotion/affect_behav2.63729067
19MP0009046_muscle_twitch2.59736338
20MP0002734_abnormal_mechanical_nocicepti2.44721815
21MP0005408_hypopigmentation2.38308718
22MP0000569_abnormal_digit_pigmentation2.33215913
23MP0005645_abnormal_hypothalamus_physiol2.27924914
24MP0005551_abnormal_eye_electrophysiolog2.27162854
25MP0002736_abnormal_nociception_after2.23707376
26MP0001188_hyperpigmentation2.22226082
27MP0002272_abnormal_nervous_system2.16875081
28MP0005646_abnormal_pituitary_gland2.14598906
29MP0001984_abnormal_olfaction2.13696392
30MP0008877_abnormal_DNA_methylation2.12501693
31MP0002733_abnormal_thermal_nociception2.10112365
32MP0002095_abnormal_skin_pigmentation2.07097216
33MP0000778_abnormal_nervous_system2.02534465
34MP0002067_abnormal_sensory_capabilities1.99724041
35MP0005187_abnormal_penis_morphology1.99641898
36MP0003787_abnormal_imprinting1.98532527
37MP0001501_abnormal_sleep_pattern1.96719564
38MP0003950_abnormal_plasma_membrane1.93745326
39MP0001970_abnormal_pain_threshold1.91965177
40MP0008058_abnormal_DNA_repair1.88724460
41MP0003183_abnormal_peptide_metabolism1.86953352
42MP0002557_abnormal_social/conspecific_i1.81924205
43MP0002184_abnormal_innervation1.81780508
44MP0000371_diluted_coat_color1.81167268
45MP0003656_abnormal_erythrocyte_physiolo1.77935155
46MP0001502_abnormal_circadian_rhythm1.76205407
47MP0002909_abnormal_adrenal_gland1.75927782
48MP0005386_behavior/neurological_phenoty1.75181939
49MP0004924_abnormal_behavior1.75181939
50MP0009780_abnormal_chondrocyte_physiolo1.73914850
51MP0006292_abnormal_olfactory_placode1.72989641
52MP0005248_abnormal_Harderian_gland1.71908793
53MP0000647_abnormal_sebaceous_gland1.70624838
54MP0001440_abnormal_grooming_behavior1.70227895
55MP0005167_abnormal_blood-brain_barrier1.69115374
56MP0000427_abnormal_hair_cycle1.64167679
57MP0004811_abnormal_neuron_physiology1.59216686
58MP0006276_abnormal_autonomic_nervous1.59089764
59MP0001529_abnormal_vocalization1.53092162
60MP0008569_lethality_at_weaning1.50019015
61MP0002882_abnormal_neuron_morphology1.49294406
62MP0004858_abnormal_nervous_system1.49213503
63MP0001299_abnormal_eye_distance/1.48947955
64MP0004885_abnormal_endolymph1.48943471
65MP0000955_abnormal_spinal_cord1.45674700
66MP0006072_abnormal_retinal_apoptosis1.42083173
67MP0002938_white_spotting1.40740019
68MP0005253_abnormal_eye_physiology1.40565730
69MP0001905_abnormal_dopamine_level1.40048534
70MP0008057_abnormal_DNA_replication1.37861949
71MP0002009_preneoplasia1.37349614
72MP0004742_abnormal_vestibular_system1.36983576
73MP0003879_abnormal_hair_cell1.34140800
74MP0005075_abnormal_melanosome_morpholog1.32631116
75MP0003121_genomic_imprinting1.31105744
76MP0002638_abnormal_pupillary_reflex1.30924150
77MP0000631_abnormal_neuroendocrine_gland1.26806245
78MP0002066_abnormal_motor_capabilities/c1.26259575
79MP0002653_abnormal_ependyma_morphology1.25043126
80MP0010386_abnormal_urinary_bladder1.24485816
81MP0001986_abnormal_taste_sensitivity1.24074731
82MP0002229_neurodegeneration1.21695146
83MP0004142_abnormal_muscle_tone1.16063428
84MP0000015_abnormal_ear_pigmentation1.15779300
85MP0005394_taste/olfaction_phenotype1.07745656
86MP0005499_abnormal_olfactory_system1.07745656
87MP0003633_abnormal_nervous_system1.07026734
88MP0002075_abnormal_coat/hair_pigmentati1.06896974
89MP0005409_darkened_coat_color1.06888919
90MP0002752_abnormal_somatic_nervous1.06193675
91MP0005257_abnormal_intraocular_pressure1.06192819
92MP0005220_abnormal_exocrine_pancreas1.05045852
93MP0002152_abnormal_brain_morphology1.02951264
94MP0001963_abnormal_hearing_physiology1.00951702
95MP0003123_paternal_imprinting1.00259857
96MP0002069_abnormal_eating/drinking_beha0.97546307
97MP0000013_abnormal_adipose_tissue0.97010545
98MP0001186_pigmentation_phenotype0.96560531
99MP0005174_abnormal_tail_pigmentation0.95724495
100MP0002876_abnormal_thyroid_physiology0.95142792
101MP0005391_vision/eye_phenotype0.94844861
102MP0005535_abnormal_body_temperature0.93696087
103MP0002090_abnormal_vision0.92809060
104MP0008007_abnormal_cellular_replicative0.92780915
105MP0010094_abnormal_chromosome_stability0.92148045
106MP0008961_abnormal_basal_metabolism0.92042709
107MP0000358_abnormal_cell_content/0.91398571
108MP0005058_abnormal_lysosome_morphology0.89784276
109MP0001919_abnormal_reproductive_system0.87401738
110MP0003786_premature_aging0.86378143
111MP0003172_abnormal_lysosome_physiology0.84800499
112MP0003122_maternal_imprinting0.84488365
113MP0003011_delayed_dark_adaptation0.84211261
114MP0003631_nervous_system_phenotype0.83927530
115MP0003111_abnormal_nucleus_morphology0.83793445
116MP0005379_endocrine/exocrine_gland_phen0.82277216
117MP0003329_amyloid_beta_deposits0.81402863
118MP0000538_abnormal_urinary_bladder0.81323195
119MP0000026_abnormal_inner_ear0.80983313
120MP0003634_abnormal_glial_cell0.79414832
121MP0005195_abnormal_posterior_eye0.79245166
122MP0008874_decreased_physiological_sensi0.78164594
123MP0003195_calcinosis0.78060153
124MP0008872_abnormal_physiological_respon0.74914436
125MP0002295_abnormal_pulmonary_circulatio0.74268567
126MP0002102_abnormal_ear_morphology0.72796750
127MP0002234_abnormal_pharynx_morphology0.72404223
128MP0008438_abnormal_cutaneous_collagen0.72272965
129MP0001944_abnormal_pancreas_morphology0.70615410
130MP0003186_abnormal_redox_activity0.69942867
131MP0003632_abnormal_nervous_system0.68929306
132MP0005171_absent_coat_pigmentation0.68860781
133MP0004510_myositis0.67830872
134MP0008932_abnormal_embryonic_tissue0.67552053
135MP0001270_distended_abdomen0.65452742
136MP0001177_atelectasis0.65032620
137MP0005310_abnormal_salivary_gland0.64301457
138MP0001664_abnormal_digestion0.63938850
139MP0002177_abnormal_outer_ear0.62697605
140MP0003690_abnormal_glial_cell0.60841576
141MP0001324_abnormal_eye_pigmentation0.56870291
142MP0003938_abnormal_ear_development0.53844209
143MP0005448_abnormal_energy_balance0.53785825
144MP0008789_abnormal_olfactory_epithelium0.53503360
145MP0002163_abnormal_gland_morphology0.51760459
146MP0010770_preweaning_lethality0.50698967
147MP0002082_postnatal_lethality0.50698967
148MP0010769_abnormal_survival0.48475427
149MP0003861_abnormal_nervous_system0.47938162

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.41153111
2Febrile seizures (HP:0002373)5.53752512
3Focal seizures (HP:0007359)4.74329111
4Epileptic encephalopathy (HP:0200134)4.52842329
5Myokymia (HP:0002411)4.19104430
6Atonic seizures (HP:0010819)4.15003508
7Visual hallucinations (HP:0002367)4.13742705
8Congenital stationary night blindness (HP:0007642)3.89199863
9Generalized tonic-clonic seizures (HP:0002069)3.75650429
10Absence seizures (HP:0002121)3.55775468
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.50112079
12Albinism (HP:0001022)3.44253785
13Dialeptic seizures (HP:0011146)3.33869858
14Abnormal rod and cone electroretinograms (HP:0008323)3.23079015
15Abnormal auditory evoked potentials (HP:0006958)3.18220397
16Broad-based gait (HP:0002136)3.10692071
17Medial flaring of the eyebrow (HP:0010747)3.09019874
18Progressive cerebellar ataxia (HP:0002073)3.07629165
19Bony spicule pigmentary retinopathy (HP:0007737)3.07015012
20Hyperventilation (HP:0002883)3.02347487
21Supranuclear gaze palsy (HP:0000605)3.01370770
22Pancreatic fibrosis (HP:0100732)2.93327669
23Drooling (HP:0002307)2.90710574
24Excessive salivation (HP:0003781)2.90710574
25Hypoplasia of the fovea (HP:0007750)2.77953684
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.77953684
27White forelock (HP:0002211)2.76272187
28Abnormality of liposaccharide metabolism (HP:0010968)2.75336530
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.75336530
30Abnormality of glycolipid metabolism (HP:0010969)2.75336530
31Protruding tongue (HP:0010808)2.71847091
32Poor eye contact (HP:0000817)2.70397845
33Type II lissencephaly (HP:0007260)2.67897192
34Decreased central vision (HP:0007663)2.65363175
35Central scotoma (HP:0000603)2.65072836
36Papilledema (HP:0001085)2.61515605
37Abnormal social behavior (HP:0012433)2.60402707
38Impaired social interactions (HP:0000735)2.60402707
39Intestinal atresia (HP:0011100)2.56194433
40Mutism (HP:0002300)2.56098294
41Limb dystonia (HP:0002451)2.54500634
42Dyschromatopsia (HP:0007641)2.52970757
43Hypopigmentation of the fundus (HP:0007894)2.51762409
44Patchy hypopigmentation of hair (HP:0011365)2.50903832
45Pancreatic cysts (HP:0001737)2.50500060
46Abnormality of the fovea (HP:0000493)2.49108747
47Abnormality of macular pigmentation (HP:0008002)2.48745287
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46055519
49Generalized hypopigmentation of hair (HP:0011358)2.45070323
50Abnormality of midbrain morphology (HP:0002418)2.42806854
51Molar tooth sign on MRI (HP:0002419)2.42806854
52Inappropriate behavior (HP:0000719)2.42616554
53Action tremor (HP:0002345)2.40270098
54Stereotypic behavior (HP:0000733)2.40062516
55Abnormal hair whorl (HP:0010721)2.38134681
56Ocular albinism (HP:0001107)2.37680881
57Upper limb muscle weakness (HP:0003484)2.36945303
58Depression (HP:0000716)2.36122326
59Truncal ataxia (HP:0002078)2.35920947
60Menstrual irregularities (HP:0000858)2.33697461
61Akinesia (HP:0002304)2.33351099
62Generalized hypopigmentation (HP:0007513)2.27874370
63Poor head control (HP:0002421)2.27540097
64Amyotrophic lateral sclerosis (HP:0007354)2.26875192
65Gait imbalance (HP:0002141)2.24601951
66True hermaphroditism (HP:0010459)2.22181222
67Hemiparesis (HP:0001269)2.21682836
68Absent speech (HP:0001344)2.21510405
69Gaze-evoked nystagmus (HP:0000640)2.20444044
70Blue irides (HP:0000635)2.19209183
71Pheochromocytoma (HP:0002666)2.19187812
72Ankle clonus (HP:0011448)2.18229984
73Inability to walk (HP:0002540)2.15767991
74Retinal dysplasia (HP:0007973)2.15137367
75Dysdiadochokinesis (HP:0002075)2.14497600
76Ependymoma (HP:0002888)2.14011760
77Poor coordination (HP:0002370)2.13476885
78Abnormality of binocular vision (HP:0011514)2.13438777
79Diplopia (HP:0000651)2.13438777
80Fetal akinesia sequence (HP:0001989)2.12228030
81Torticollis (HP:0000473)2.11756580
82Neuroendocrine neoplasm (HP:0100634)2.11026658
83Progressive inability to walk (HP:0002505)2.10776083
84Abnormal eating behavior (HP:0100738)2.07828926
85Postural instability (HP:0002172)2.07434219
86Epileptiform EEG discharges (HP:0011182)2.07107964
87Anxiety (HP:0000739)2.06431245
88Urinary bladder sphincter dysfunction (HP:0002839)2.05610528
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.05523618
90Anosmia (HP:0000458)2.04494105
91Fair hair (HP:0002286)2.04196130
92Large for gestational age (HP:0001520)2.03811405
93Pigmentary retinal degeneration (HP:0001146)2.03340711
94Amblyopia (HP:0000646)2.03088109
95Cutaneous melanoma (HP:0012056)2.02772662
96EEG with generalized epileptiform discharges (HP:0011198)2.01663924
97Adrenal hypoplasia (HP:0000835)2.01466217
98Bradykinesia (HP:0002067)1.99194437
99Abnormality of alanine metabolism (HP:0010916)1.98508980
100Hyperalaninemia (HP:0003348)1.98508980
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98508980
102Iris hypopigmentation (HP:0007730)1.98479451
103Cerebellar dysplasia (HP:0007033)1.97514874
104Impaired smooth pursuit (HP:0007772)1.96600331
105Freckling (HP:0001480)1.95452005
106Abnormality of salivation (HP:0100755)1.93862956
107Severe visual impairment (HP:0001141)1.93765510
108Cortical dysplasia (HP:0002539)1.92140001
109Short tibia (HP:0005736)1.91994253
110Status epilepticus (HP:0002133)1.90923032
111Aplasia/Hypoplasia of the macula (HP:0008059)1.90243752
112Dysmetria (HP:0001310)1.89995529
113Impaired vibration sensation in the lower limbs (HP:0002166)1.89728192
114Septo-optic dysplasia (HP:0100842)1.89237249
115Short foot (HP:0001773)1.87025523
116Polyphagia (HP:0002591)1.86812868
117CNS hypomyelination (HP:0003429)1.85563305
118Disproportionate short-trunk short stature (HP:0003521)1.84377159
119Lissencephaly (HP:0001339)1.84339773
120Hypsarrhythmia (HP:0002521)1.84235368
121Neoplasm of the adrenal cortex (HP:0100641)1.83839076
122Generalized myoclonic seizures (HP:0002123)1.83594727
123Attenuation of retinal blood vessels (HP:0007843)1.82709214
124Volvulus (HP:0002580)1.81551547
125Neoplasm of the peripheral nervous system (HP:0100007)1.78958640
126Photophobia (HP:0000613)1.78779274
127Focal dystonia (HP:0004373)1.78185860
128Tubulointerstitial nephritis (HP:0001970)1.78148762
129Insomnia (HP:0100785)1.78075399
130Nephrogenic diabetes insipidus (HP:0009806)1.77736962
131Astigmatism (HP:0000483)1.77506260
132Genetic anticipation (HP:0003743)1.77307972
133Autism (HP:0000717)1.76502858
134Postaxial hand polydactyly (HP:0001162)1.76486014
135Abnormality of ocular smooth pursuit (HP:0000617)1.75226070
136Hematochezia (HP:0002573)1.75145412
137Nephronophthisis (HP:0000090)1.74873464
138Spastic gait (HP:0002064)1.74437765
139Broad foot (HP:0001769)1.74386775
140Psychosis (HP:0000709)1.73758982
141Failure to thrive in infancy (HP:0001531)1.73064543
142Spinal canal stenosis (HP:0003416)1.72695305
143Astrocytoma (HP:0009592)1.72342802
144Abnormality of the astrocytes (HP:0100707)1.72342802
145Postaxial foot polydactyly (HP:0001830)1.72222183
146Hemiplegia (HP:0002301)1.68981664
147Scotoma (HP:0000575)1.68922602
148Exotropia (HP:0000577)1.68445782
149Gastroesophageal reflux (HP:0002020)1.67525974
150Macroglossia (HP:0000158)1.67400012
151Aplasia/Hypoplasia affecting the retina (HP:0008061)1.66699986
152Tented upper lip vermilion (HP:0010804)1.66649776
153Congenital primary aphakia (HP:0007707)1.66321889
154Orthostatic hypotension (HP:0001278)1.65724496
155Deeply set eye (HP:0000490)1.65597085
156Hypothermia (HP:0002045)1.65380679
157Widely spaced teeth (HP:0000687)1.65332045
158Lower limb amyotrophy (HP:0007210)1.65105072
159Neurofibrillary tangles (HP:0002185)1.64896107
160Chronic hepatic failure (HP:0100626)1.64860259
161Glioma (HP:0009733)1.64724614
162Breast carcinoma (HP:0003002)1.64681758
163Oligodactyly (hands) (HP:0001180)1.64090529
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.62215397
165Follicular hyperkeratosis (HP:0007502)1.61480884
166Long toe (HP:0010511)1.61069777
167Aganglionic megacolon (HP:0002251)1.60370482
168Abnormality of the renal medulla (HP:0100957)1.60214684
169Bile duct proliferation (HP:0001408)1.60008737
170Abnormal biliary tract physiology (HP:0012439)1.60008737
171Submucous cleft hard palate (HP:0000176)1.59940435
172Prominent nasal bridge (HP:0000426)1.57685870
173Pachygyria (HP:0001302)1.57180188
174Oculomotor apraxia (HP:0000657)1.56090245
175Neoplasm of the adrenal gland (HP:0100631)1.55694141
176Heterochromia iridis (HP:0001100)1.53700647
177Mitral stenosis (HP:0001718)1.53693021
178Hypoplasia of the odontoid process (HP:0003311)1.52990883
179Postural tremor (HP:0002174)1.52772969
180Postnatal microcephaly (HP:0005484)1.52695892
181Hand muscle atrophy (HP:0009130)1.52232399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.35473631
2NTRK33.65877738
3TIE13.62272745
4MAP2K73.34702315
5MAP3K43.08496515
6EIF2AK32.94603181
7CASK2.89030936
8EPHA42.80755986
9ACVR1B2.59893506
10NTRK22.57563150
11SIK22.53176063
12TRIM282.50235402
13EIF2AK12.36857185
14MAP3K92.34473818
15TNIK2.30161351
16MAP3K122.27235393
17WEE12.22214167
18WNK32.17066898
19MAPK132.14708008
20BMPR1B2.13774027
21MINK11.95162131
22PRPF4B1.91599856
23FER1.90091713
24DAPK21.89164584
25BCR1.85844732
26LIMK11.83115842
27PBK1.80757405
28MAP2K41.77820311
29CCNB11.60734608
30BRSK21.53224409
31FES1.52255728
32SGK21.49147564
33STK31.42746542
34PLK31.42359663
35CSNK1G31.41020972
36CSNK1A1L1.40635622
37PAK61.40454100
38CAMKK11.37443391
39RIPK41.37011287
40CDK51.33653520
41TNK21.32539766
42KSR11.29659113
43PRKD31.28198588
44ERBB31.26002406
45DAPK11.25791558
46CSNK1G11.20056041
47NUAK11.19058603
48SGK31.16765815
49PRKCH1.14600607
50NTRK11.14247923
51MAP3K131.13349065
52NEK11.13127212
53SIK31.12097497
54NEK91.11362684
55MKNK21.11181408
56STK381.08760139
57PTK2B1.07391514
58MARK21.07016986
59SGK4941.06261516
60SGK2231.06261516
61GRK11.05303535
62TGFBR11.04943118
63TXK1.04456881
64ADRBK21.04263250
65PLK21.03850660
66GRK51.02971789
67MAP4K21.02132673
68BRSK11.01981410
69UHMK11.01723098
70CAMK1D1.00741565
71CAMK1G0.99639063
72PDK20.99630444
73PRKCG0.99481912
74TAOK10.99067190
75CLK10.97517487
76MAP3K60.93473965
77BRD40.90375887
78PHKG20.88319415
79PHKG10.88319415
80PIM20.88135141
81DYRK1A0.85961015
82INSRR0.81920789
83ZAK0.81562665
84TSSK60.80795885
85SGK10.79942371
86CAMK2A0.77825770
87ALK0.77821936
88AKT30.77434206
89CAMK10.76935061
90PLK10.75805381
91TEC0.75732583
92BCKDK0.75610380
93STK110.75058294
94BMPR20.74160349
95CSNK1G20.73640439
96LATS20.71756929
97FGFR20.71675936
98ERBB40.70354978
99EIF2AK20.69062184
100YES10.68224458
101LMTK20.67841701
102CAMKK20.67777409
103CDK60.66401813
104DYRK20.65750610
105PRKCZ0.64611536
106KSR20.63869932
107ADRBK10.62321250
108MUSK0.60761209
109PKN10.60526635
110SRPK10.59397151
111BLK0.56758978
112PDK10.56567609
113PNCK0.56333295
114FYN0.55780125
115PRKCI0.55647654
116RET0.55379552
117CDK180.53795692
118HIPK20.52438013
119ATM0.51378635
120MAPK120.51166648
121CDK150.50770936
122PRKCE0.50647564
123CDK30.50219326
124NEK20.50067309
125GRK60.49797872
126TGFBR20.49078242
127SYK0.49005740
128PAK20.48480511
129RPS6KB10.47243967
130HCK0.46995886
131MAP3K10.46931027
132BUB10.45799598
133PRKCB0.45468897
134BRAF0.45033928
135LATS10.44989692
136CAMK40.44657501
137MAP3K20.44462777
138TAOK30.44321716
139CDK140.43723956
140PAK30.43559598
141TTK0.42936449
142RPS6KA30.42525121
143PLK40.42163555
144MAPK100.41480806
145CDK11A0.41385450
146CSNK1A10.40972123
147CSNK1D0.40537969
148PINK10.40202299
149STK160.39065213
150PDPK10.38731202
151MET0.38622291
152NEK60.38529405
153PTK20.38498161
154CAMK2B0.38326134
155JAK10.37778402
156MAPK70.37367353
157PRKAA20.35859423
158ROCK20.35487275
159FRK0.35135238
160CHEK20.33793304
161ATR0.32835988
162EGFR0.30507241
163CDK80.30232833
164GSK3A0.30097800

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73361950
2Phototransduction_Homo sapiens_hsa047443.16516797
3Olfactory transduction_Homo sapiens_hsa047403.12187897
4Synaptic vesicle cycle_Homo sapiens_hsa047212.95265093
5Morphine addiction_Homo sapiens_hsa050322.72574428
6GABAergic synapse_Homo sapiens_hsa047272.66317528
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64885557
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62528178
9Steroid biosynthesis_Homo sapiens_hsa001002.56257586
10Protein export_Homo sapiens_hsa030602.49318350
11Glutamatergic synapse_Homo sapiens_hsa047242.46840009
12Propanoate metabolism_Homo sapiens_hsa006402.45637032
13Circadian entrainment_Homo sapiens_hsa047132.34561285
14Dopaminergic synapse_Homo sapiens_hsa047282.07394162
15Insulin secretion_Homo sapiens_hsa049112.04727189
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02717211
17Long-term potentiation_Homo sapiens_hsa047202.02105877
18Amphetamine addiction_Homo sapiens_hsa050311.95113537
19Cholinergic synapse_Homo sapiens_hsa047251.95051037
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88530422
21Taste transduction_Homo sapiens_hsa047421.86572735
22Non-homologous end-joining_Homo sapiens_hsa034501.85182594
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84413981
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83287671
25Serotonergic synapse_Homo sapiens_hsa047261.82316699
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.79776581
27Salivary secretion_Homo sapiens_hsa049701.75315158
28Fanconi anemia pathway_Homo sapiens_hsa034601.71847024
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60642508
30Cocaine addiction_Homo sapiens_hsa050301.59909086
31Butanoate metabolism_Homo sapiens_hsa006501.58921077
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54692238
33Regulation of autophagy_Homo sapiens_hsa041401.49691909
34Gastric acid secretion_Homo sapiens_hsa049711.48084935
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46932708
36Basal transcription factors_Homo sapiens_hsa030221.45863397
37Homologous recombination_Homo sapiens_hsa034401.44500457
38Fatty acid elongation_Homo sapiens_hsa000621.42010281
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40114885
40Renin secretion_Homo sapiens_hsa049241.39298462
41Calcium signaling pathway_Homo sapiens_hsa040201.38416529
42Long-term depression_Homo sapiens_hsa047301.38200098
43Type II diabetes mellitus_Homo sapiens_hsa049301.37919147
44Selenocompound metabolism_Homo sapiens_hsa004501.34196517
45Lysosome_Homo sapiens_hsa041421.30026931
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30026223
47Nucleotide excision repair_Homo sapiens_hsa034201.29895108
48Oxytocin signaling pathway_Homo sapiens_hsa049211.26576187
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26049260
50Peroxisome_Homo sapiens_hsa041461.24079816
51Fatty acid biosynthesis_Homo sapiens_hsa000611.23849585
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23459095
53Sphingolipid metabolism_Homo sapiens_hsa006001.21820720
54GnRH signaling pathway_Homo sapiens_hsa049121.21653847
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20351374
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18934753
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16503861
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15060542
59Mismatch repair_Homo sapiens_hsa034301.14918011
60Axon guidance_Homo sapiens_hsa043601.14138016
61Fatty acid metabolism_Homo sapiens_hsa012121.12173506
62cAMP signaling pathway_Homo sapiens_hsa040241.10527912
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08614290
64ErbB signaling pathway_Homo sapiens_hsa040121.07963561
65Sulfur metabolism_Homo sapiens_hsa009201.06384016
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.05082883
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04910113
68RNA degradation_Homo sapiens_hsa030181.00067915
69Nitrogen metabolism_Homo sapiens_hsa009100.97239985
70Cell cycle_Homo sapiens_hsa041100.97181057
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97117443
72p53 signaling pathway_Homo sapiens_hsa041150.96129183
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95929087
74Type I diabetes mellitus_Homo sapiens_hsa049400.93513556
75RNA polymerase_Homo sapiens_hsa030200.93194069
76Gap junction_Homo sapiens_hsa045400.91110439
77Other glycan degradation_Homo sapiens_hsa005110.89756060
78Folate biosynthesis_Homo sapiens_hsa007900.89410193
79Dorso-ventral axis formation_Homo sapiens_hsa043200.89124133
80Lysine degradation_Homo sapiens_hsa003100.88858758
81Melanogenesis_Homo sapiens_hsa049160.87385491
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85355923
83Estrogen signaling pathway_Homo sapiens_hsa049150.84958226
84Glioma_Homo sapiens_hsa052140.84248999
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83850724
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.82800156
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82309676
88Pyruvate metabolism_Homo sapiens_hsa006200.81700937
89beta-Alanine metabolism_Homo sapiens_hsa004100.81018080
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80900032
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80388418
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78579321
93Choline metabolism in cancer_Homo sapiens_hsa052310.78220050
94Collecting duct acid secretion_Homo sapiens_hsa049660.76628937
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74773151
96Chemokine signaling pathway_Homo sapiens_hsa040620.74326275
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72983650
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72621518
99MAPK signaling pathway_Homo sapiens_hsa040100.70801273
100Circadian rhythm_Homo sapiens_hsa047100.69232898
101Purine metabolism_Homo sapiens_hsa002300.68888926
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68460512
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67662882
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67428364
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66762288
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.64584245
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62034835
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61782491
109RNA transport_Homo sapiens_hsa030130.61146377
110Pancreatic secretion_Homo sapiens_hsa049720.59894842
111Thyroid hormone synthesis_Homo sapiens_hsa049180.59351865
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.59187389
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58696898
114Inositol phosphate metabolism_Homo sapiens_hsa005620.58609703
115Melanoma_Homo sapiens_hsa052180.58203288
116Endometrial cancer_Homo sapiens_hsa052130.58182711
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57276641
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.56517154
119Ras signaling pathway_Homo sapiens_hsa040140.56114798
120T cell receptor signaling pathway_Homo sapiens_hsa046600.55690048
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.55579492
122Vibrio cholerae infection_Homo sapiens_hsa051100.55218421
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53437187
124Rap1 signaling pathway_Homo sapiens_hsa040150.52947339
125Prostate cancer_Homo sapiens_hsa052150.52945020
126Glucagon signaling pathway_Homo sapiens_hsa049220.50835929
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.50822200
128Hippo signaling pathway_Homo sapiens_hsa043900.50662809
129Mineral absorption_Homo sapiens_hsa049780.48757759
130Ovarian steroidogenesis_Homo sapiens_hsa049130.48547226
131Vitamin B6 metabolism_Homo sapiens_hsa007500.48436649
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48372846
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47254270
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47205203
135African trypanosomiasis_Homo sapiens_hsa051430.46595783
136Prolactin signaling pathway_Homo sapiens_hsa049170.46345970
137Metabolic pathways_Homo sapiens_hsa011000.45582173
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45478374
139One carbon pool by folate_Homo sapiens_hsa006700.44529079
140Pyrimidine metabolism_Homo sapiens_hsa002400.44263256
141Tryptophan metabolism_Homo sapiens_hsa003800.44178504
142Non-small cell lung cancer_Homo sapiens_hsa052230.44072776
143Adherens junction_Homo sapiens_hsa045200.43480923
144FoxO signaling pathway_Homo sapiens_hsa040680.42939731
145mTOR signaling pathway_Homo sapiens_hsa041500.42444099
146Wnt signaling pathway_Homo sapiens_hsa043100.42265603
147Bile secretion_Homo sapiens_hsa049760.40427466
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39565350
149Glutathione metabolism_Homo sapiens_hsa004800.39101942
150Insulin signaling pathway_Homo sapiens_hsa049100.38841114
151ABC transporters_Homo sapiens_hsa020100.38274886
152Shigellosis_Homo sapiens_hsa051310.38049165
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37766643
154mRNA surveillance pathway_Homo sapiens_hsa030150.35435504
155TGF-beta signaling pathway_Homo sapiens_hsa043500.34892526
156Colorectal cancer_Homo sapiens_hsa052100.34229488
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31453091
158Osteoclast differentiation_Homo sapiens_hsa043800.31084473
159Endocytosis_Homo sapiens_hsa041440.30592058
160Dilated cardiomyopathy_Homo sapiens_hsa054140.29670598
161N-Glycan biosynthesis_Homo sapiens_hsa005100.29471973
162VEGF signaling pathway_Homo sapiens_hsa043700.29338767
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28810023
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28541906
165Tuberculosis_Homo sapiens_hsa051520.27482307
166Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24258087
167Oocyte meiosis_Homo sapiens_hsa041140.24197956

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