SEC22A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.66967587
2protein deneddylation (GO:0000338)5.46667104
3cullin deneddylation (GO:0010388)4.82391975
4protein neddylation (GO:0045116)4.78135233
5piRNA metabolic process (GO:0034587)4.67352670
6proteasome assembly (GO:0043248)4.25336883
7synapsis (GO:0007129)4.15482967
8signal peptide processing (GO:0006465)4.05607256
9intraciliary transport (GO:0042073)4.02727004
10regulation of female gonad development (GO:2000194)4.01798426
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90978872
12energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89007728
13ATP synthesis coupled proton transport (GO:0015986)3.89007728
14regulation of meiosis I (GO:0060631)3.87113167
15peptidyl-histidine modification (GO:0018202)3.77184214
16nucleotide transmembrane transport (GO:1901679)3.76052995
17viral mRNA export from host cell nucleus (GO:0046784)3.74699285
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71163156
19base-excision repair, AP site formation (GO:0006285)3.66558576
20CENP-A containing nucleosome assembly (GO:0034080)3.65555584
21water-soluble vitamin biosynthetic process (GO:0042364)3.65312698
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56765217
23positive regulation of mitochondrial fission (GO:0090141)3.53466446
24rRNA methylation (GO:0031167)3.51836430
25chromatin remodeling at centromere (GO:0031055)3.51534114
26behavioral response to nicotine (GO:0035095)3.50853895
27cellular ketone body metabolic process (GO:0046950)3.46779778
28protein complex biogenesis (GO:0070271)3.44588722
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42401331
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.42401331
31NADH dehydrogenase complex assembly (GO:0010257)3.42401331
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41487910
33rRNA modification (GO:0000154)3.40588596
34retinal cone cell development (GO:0046549)3.36288232
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35564652
36platelet dense granule organization (GO:0060155)3.34127363
37male meiosis I (GO:0007141)3.33859369
387-methylguanosine mRNA capping (GO:0006370)3.30082329
39protein K11-linked ubiquitination (GO:0070979)3.27657576
40replication fork processing (GO:0031297)3.26721707
41ubiquinone biosynthetic process (GO:0006744)3.24249142
42ketone body metabolic process (GO:1902224)3.22994509
43mannosylation (GO:0097502)3.21658203
44indolalkylamine metabolic process (GO:0006586)3.20779522
45ubiquinone metabolic process (GO:0006743)3.17903882
46RNA capping (GO:0036260)3.15305554
477-methylguanosine RNA capping (GO:0009452)3.15305554
48respiratory chain complex IV assembly (GO:0008535)3.13213514
49cilium morphogenesis (GO:0060271)3.12562353
50protein-cofactor linkage (GO:0018065)3.11240503
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10571106
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09938916
53pyrimidine nucleotide catabolic process (GO:0006244)3.09649475
54respiratory electron transport chain (GO:0022904)3.08129714
55regulation of cellular amino acid metabolic process (GO:0006521)3.08077025
56GTP biosynthetic process (GO:0006183)3.07286712
57purine ribonucleotide transport (GO:0015868)3.04657557
58male meiosis (GO:0007140)3.03439845
59centriole replication (GO:0007099)3.01403899
60electron transport chain (GO:0022900)3.01342105
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.00965614
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00911804
63DNA double-strand break processing (GO:0000729)3.00224421
64viral protein processing (GO:0019082)3.00105961
65epithelial cilium movement (GO:0003351)2.99300418
66organelle disassembly (GO:1903008)2.97551195
67detection of light stimulus involved in visual perception (GO:0050908)2.95972418
68detection of light stimulus involved in sensory perception (GO:0050962)2.95972418
69negative regulation of ligase activity (GO:0051352)2.95698137
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95698137
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95219771
72nonmotile primary cilium assembly (GO:0035058)2.93676774
73resolution of meiotic recombination intermediates (GO:0000712)2.92482624
74reciprocal meiotic recombination (GO:0007131)2.92309548
75reciprocal DNA recombination (GO:0035825)2.92309548
76attachment of spindle microtubules to kinetochore (GO:0008608)2.90817186
77kynurenine metabolic process (GO:0070189)2.90704258
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89363328
79DNA methylation involved in gamete generation (GO:0043046)2.89301344
80mitochondrial respiratory chain complex assembly (GO:0033108)2.87800193
81glycerophospholipid catabolic process (GO:0046475)2.86753139
82L-fucose catabolic process (GO:0042355)2.85814478
83fucose catabolic process (GO:0019317)2.85814478
84L-fucose metabolic process (GO:0042354)2.85814478
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.85739757
86ER overload response (GO:0006983)2.85246330
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84463344
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84463344
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84463344
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83727095
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83727095
92response to pheromone (GO:0019236)2.83235932
93ribonucleoprotein complex disassembly (GO:0032988)2.81501813
94C-terminal protein lipidation (GO:0006501)2.81213766
95maturation of 5.8S rRNA (GO:0000460)2.80920868
96guanosine-containing compound biosynthetic process (GO:1901070)2.80387395
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80031988
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79080699
99regulation of metalloenzyme activity (GO:0048552)2.78449295
100multicellular organism reproduction (GO:0032504)2.77521084
101C-terminal protein amino acid modification (GO:0018410)2.76836240
102L-methionine salvage (GO:0071267)2.75197847
103L-methionine biosynthetic process (GO:0071265)2.75197847
104amino acid salvage (GO:0043102)2.75197847
105recombinational repair (GO:0000725)2.75082605
106double-strand break repair via homologous recombination (GO:0000724)2.74676793
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74368453
108histone exchange (GO:0043486)2.73661294
109termination of RNA polymerase III transcription (GO:0006386)2.72906062
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.72906062
111neural tube formation (GO:0001841)2.71174138
112notochord development (GO:0030903)2.71145154
113oxidative phosphorylation (GO:0006119)2.71111634
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.70917652
115indole-containing compound catabolic process (GO:0042436)2.70627040
116indolalkylamine catabolic process (GO:0046218)2.70627040
117tryptophan catabolic process (GO:0006569)2.70627040
118positive regulation of ligase activity (GO:0051351)2.70437522
119tryptophan metabolic process (GO:0006568)2.69502992
120transcription elongation from RNA polymerase II promoter (GO:0006368)2.68800777
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68540937
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.68540937
123meiotic cell cycle (GO:0051321)2.67591331
124axoneme assembly (GO:0035082)2.67175027
125negative regulation of keratinocyte proliferation (GO:0010839)2.66040969
126GPI anchor metabolic process (GO:0006505)2.65540097
127protein localization to cilium (GO:0061512)2.65174464
128oxidative demethylation (GO:0070989)2.64847283
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64008654
130misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.63745585
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63437021
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.63437021
133rRNA catabolic process (GO:0016075)2.63252219
134deoxyribonucleotide catabolic process (GO:0009264)2.63071050
135meiosis I (GO:0007127)2.62629567
136indole-containing compound metabolic process (GO:0042430)2.61692422
137deoxyribose phosphate biosynthetic process (GO:0046385)2.61687530
1382-deoxyribonucleotide biosynthetic process (GO:0009265)2.61687530
139regulation of cilium movement (GO:0003352)2.60858340
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.60688493
141cilium organization (GO:0044782)2.60626422
142DNA deamination (GO:0045006)2.60580287
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60493870
144estrogen biosynthetic process (GO:0006703)2.60353030
145deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60036089
146negative regulation of mast cell activation (GO:0033004)2.60025583
147positive regulation of protein targeting to membrane (GO:0090314)2.59553718
148CTP metabolic process (GO:0046036)2.59511506
149CTP biosynthetic process (GO:0006241)2.59511506
150heart process (GO:0003015)2.58853856
151heart contraction (GO:0060047)2.58853856
152primary amino compound metabolic process (GO:1901160)2.58695244
153serotonin metabolic process (GO:0042428)2.57949014
154protein K6-linked ubiquitination (GO:0085020)2.57910300
155cytochrome complex assembly (GO:0017004)2.57129699
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56363045
157quinone biosynthetic process (GO:1901663)2.55301032
158regulation of acrosome reaction (GO:0060046)2.55260434
159cilium assembly (GO:0042384)2.54974299
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54836342
161DNA replication-independent nucleosome organization (GO:0034724)2.54621485
162DNA replication-independent nucleosome assembly (GO:0006336)2.54621485
163tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54057466
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54057466
165chromosome organization involved in meiosis (GO:0070192)2.53934426
166preassembly of GPI anchor in ER membrane (GO:0016254)2.53105737
167DNA demethylation (GO:0080111)2.53101637
168tRNA processing (GO:0008033)2.52210705
169antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49540294
170methionine metabolic process (GO:0006555)2.47624889
171tachykinin receptor signaling pathway (GO:0007217)2.45171553
172photoreceptor cell development (GO:0042461)2.43188403
173regulation of glucokinase activity (GO:0033131)2.42805558
174regulation of hexokinase activity (GO:1903299)2.42805558
175pyrimidine nucleobase catabolic process (GO:0006208)2.41997896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39254015
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.49580231
3ZNF274_21170338_ChIP-Seq_K562_Hela3.48094730
4EZH2_22144423_ChIP-Seq_EOC_Human3.00797754
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98753032
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.76836497
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70315778
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67411306
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.54877475
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54275202
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53180137
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49755655
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42242215
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34403813
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.18701938
16VDR_22108803_ChIP-Seq_LS180_Human2.18157275
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16863492
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11628570
19* SRF_21415370_ChIP-Seq_HL-1_Mouse2.09816826
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06315424
21ELK1_19687146_ChIP-ChIP_HELA_Human1.93636219
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93251968
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91065310
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88255212
25FUS_26573619_Chip-Seq_HEK293_Human1.87284179
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84459886
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.75088348
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74010041
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73649550
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72800855
31DCP1A_22483619_ChIP-Seq_HELA_Human1.72615798
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.66667592
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62281329
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59062112
35CBP_20019798_ChIP-Seq_JUKART_Human1.59062112
36EWS_26573619_Chip-Seq_HEK293_Human1.58518939
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58463754
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58434813
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56284447
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.56077578
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55487296
42VDR_23849224_ChIP-Seq_CD4+_Human1.54287742
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53804533
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53230595
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48702231
46GBX2_23144817_ChIP-Seq_PC3_Human1.48134565
47P300_19829295_ChIP-Seq_ESCs_Human1.47469907
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46979066
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45899578
50SMAD4_21799915_ChIP-Seq_A2780_Human1.42835314
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41117044
52MYC_18940864_ChIP-ChIP_HL60_Human1.41048050
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.40877059
54TP53_22573176_ChIP-Seq_HFKS_Human1.40481747
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40147229
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40130172
57IRF1_19129219_ChIP-ChIP_H3396_Human1.39967944
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38967313
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.37870645
60TAF15_26573619_Chip-Seq_HEK293_Human1.37666385
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37504244
62BCAT_22108803_ChIP-Seq_LS180_Human1.35360790
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34082456
64AR_25329375_ChIP-Seq_VCAP_Human1.33978800
65* STAT3_23295773_ChIP-Seq_U87_Human1.33432800
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.32700326
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30739891
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29548342
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.29095083
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.27685136
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.27054261
72ER_23166858_ChIP-Seq_MCF-7_Human1.26971497
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26404530
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25690688
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25612156
76FOXP3_21729870_ChIP-Seq_TREG_Human1.25493010
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25431027
78* TCF4_23295773_ChIP-Seq_U87_Human1.24303223
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23659175
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.23659175
81NANOG_19829295_ChIP-Seq_ESCs_Human1.23370144
82SOX2_19829295_ChIP-Seq_ESCs_Human1.23370144
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22935783
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22219808
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21945392
86AR_21909140_ChIP-Seq_LNCAP_Human1.21844567
87TCF4_22108803_ChIP-Seq_LS180_Human1.21299516
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20872557
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19306893
90P53_22387025_ChIP-Seq_ESCs_Mouse1.18480928
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18369392
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.17934229
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.17562960
94REST_19997604_ChIP-ChIP_NEURONS_Mouse1.16484931
95GABP_19822575_ChIP-Seq_HepG2_Human1.16256128
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15829751
97RUNX2_22187159_ChIP-Seq_PCA_Human1.15470937
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.15173822
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14664144
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.13736276
101HTT_18923047_ChIP-ChIP_STHdh_Human1.13073980
102AR_20517297_ChIP-Seq_VCAP_Human1.12967516
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12270067
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.11427973
105MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10967855
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10466784
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.10389155
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09956776
109RNF2_27304074_Chip-Seq_NSC_Mouse1.09780717
110P300_18555785_Chip-Seq_ESCs_Mouse1.09658549
111CDX2_22108803_ChIP-Seq_LS180_Human1.09606470
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.09454861
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09453000
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08888055
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08887966
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08196839
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08185316
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07831379
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.07352242
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06831772
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06523641
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.06513566
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05483679
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.05260221
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05012612
126* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04247685
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03602597
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03440580
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.03305770
130ZFX_18555785_Chip-Seq_ESCs_Mouse1.02918644
131IGF1R_20145208_ChIP-Seq_DFB_Human1.02780780
132* NCOR_22424771_ChIP-Seq_293T_Human1.01854419
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.01601682
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.01424551
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00741788
136FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99588864
137JUN_21703547_ChIP-Seq_K562_Human0.99033330
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98999181
139ERG_20517297_ChIP-Seq_VCAP_Human0.98878930
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98796396
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98661855
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98587183
143E2F1_18555785_Chip-Seq_ESCs_Mouse0.98515824
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.98095057
145STAT1_17558387_ChIP-Seq_HELA_Human0.96753730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.48721228
2MP0003718_maternal_effect3.49517032
3MP0005646_abnormal_pituitary_gland3.42023083
4MP0010386_abnormal_urinary_bladder3.09464759
5MP0005408_hypopigmentation2.70249587
6MP0003123_paternal_imprinting2.19402128
7MP0003195_calcinosis2.16028558
8MP0002163_abnormal_gland_morphology2.12454712
9MP0003315_abnormal_perineum_morphology2.11862080
10MP0001529_abnormal_vocalization2.11675072
11MP0003011_delayed_dark_adaptation2.10261578
12MP0004147_increased_porphyrin_level2.09742327
13MP0008875_abnormal_xenobiotic_pharmacok2.09225164
14MP0003646_muscle_fatigue2.06304867
15MP0002938_white_spotting2.01910627
16MP0005379_endocrine/exocrine_gland_phen1.99863006
17MP0008877_abnormal_DNA_methylation1.98497118
18MP0006292_abnormal_olfactory_placode1.96410279
19MP0005451_abnormal_body_composition1.96267113
20MP0004782_abnormal_surfactant_physiolog1.87785851
21MP0001905_abnormal_dopamine_level1.87567751
22MP0002876_abnormal_thyroid_physiology1.79533015
23MP0003693_abnormal_embryo_hatching1.76649962
24MP0003950_abnormal_plasma_membrane1.75133462
25MP0003136_yellow_coat_color1.73105360
26MP0003806_abnormal_nucleotide_metabolis1.71806885
27MP0000427_abnormal_hair_cycle1.71756888
28MP0004142_abnormal_muscle_tone1.71522131
29MP0002638_abnormal_pupillary_reflex1.68031910
30MP0006276_abnormal_autonomic_nervous1.66595873
31MP0008789_abnormal_olfactory_epithelium1.62421276
32MP0001764_abnormal_homeostasis1.61729275
33MP0002282_abnormal_trachea_morphology1.61307630
34MP0004043_abnormal_pH_regulation1.61153897
35MP0000678_abnormal_parathyroid_gland1.58143793
36MP0003186_abnormal_redox_activity1.54565805
37MP0006072_abnormal_retinal_apoptosis1.49307708
38MP0005551_abnormal_eye_electrophysiolog1.49073425
39MP0000569_abnormal_digit_pigmentation1.48926306
40MP0001119_abnormal_female_reproductive1.45599539
41MP0003121_genomic_imprinting1.44161783
42MP0000566_synostosis1.44001359
43MP0009384_cardiac_valve_regurgitation1.43256044
44MP0005389_reproductive_system_phenotype1.42268353
45MP0000647_abnormal_sebaceous_gland1.41762253
46MP0001346_abnormal_lacrimal_gland1.41517191
47MP0001968_abnormal_touch/_nociception1.41051537
48MP0000013_abnormal_adipose_tissue1.40800872
49MP0002272_abnormal_nervous_system1.40451591
50MP0008932_abnormal_embryonic_tissue1.40273706
51MP0000631_abnormal_neuroendocrine_gland1.39704165
52MP0002234_abnormal_pharynx_morphology1.38853297
53MP0002160_abnormal_reproductive_system1.38367328
54MP0005645_abnormal_hypothalamus_physiol1.37437634
55MP0005395_other_phenotype1.36830569
56MP0002928_abnormal_bile_duct1.35669499
57MP0005499_abnormal_olfactory_system1.34701022
58MP0005394_taste/olfaction_phenotype1.34701022
59MP0002295_abnormal_pulmonary_circulatio1.32251664
60MP0009780_abnormal_chondrocyte_physiolo1.27852151
61MP0001919_abnormal_reproductive_system1.27506326
62MP0005075_abnormal_melanosome_morpholog1.27472214
63MP0008872_abnormal_physiological_respon1.27435102
64MP0004957_abnormal_blastocyst_morpholog1.26743169
65MP0009046_muscle_twitch1.26383996
66MP0003786_premature_aging1.25233776
67MP0008057_abnormal_DNA_replication1.22335220
68MP0001542_abnormal_bone_strength1.21697825
69MP0008995_early_reproductive_senescence1.21569642
70MP0003787_abnormal_imprinting1.21229564
71MP0000613_abnormal_salivary_gland1.19688199
72MP0000538_abnormal_urinary_bladder1.17820282
73MP0001929_abnormal_gametogenesis1.16677967
74MP0002095_abnormal_skin_pigmentation1.16646612
75MP0002653_abnormal_ependyma_morphology1.15569967
76MP0009745_abnormal_behavioral_response1.13678349
77MP0004885_abnormal_endolymph1.13629046
78MP0005171_absent_coat_pigmentation1.13480618
79MP0003698_abnormal_male_reproductive1.13072011
80MP0005253_abnormal_eye_physiology1.13054920
81MP0009379_abnormal_foot_pigmentation1.12408186
82MP0005360_urolithiasis1.12257651
83MP0002139_abnormal_hepatobiliary_system1.11377444
84MP0010094_abnormal_chromosome_stability1.10480738
85MP0001984_abnormal_olfaction1.09250789
86MP0008260_abnormal_autophagy1.08203875
87MP0001145_abnormal_male_reproductive1.07342799
88MP0004133_heterotaxia1.06203500
89MP0000653_abnormal_sex_gland1.05873300
90MP0003252_abnormal_bile_duct1.05785511
91MP0001293_anophthalmia1.05661732
92MP0001486_abnormal_startle_reflex1.04818047
93MP0000049_abnormal_middle_ear1.04590478
94MP0004134_abnormal_chest_morphology1.04461232
95MP0009250_abnormal_appendicular_skeleto1.03358916
96MP0005084_abnormal_gallbladder_morpholo1.03343156
97MP0005195_abnormal_posterior_eye1.03115091
98MP0002210_abnormal_sex_determination1.03062748
99MP0000383_abnormal_hair_follicle1.00576051
100MP0006036_abnormal_mitochondrial_physio0.99932399
101MP0002837_dystrophic_cardiac_calcinosis0.99458051
102MP0003937_abnormal_limbs/digits/tail_de0.98492257
103MP0002735_abnormal_chemical_nociception0.95023358
104MP0003890_abnormal_embryonic-extraembry0.94169256
105MP0006035_abnormal_mitochondrial_morpho0.93120716
106MP0002557_abnormal_social/conspecific_i0.93010978
107MP0005187_abnormal_penis_morphology0.90962076
108MP0002233_abnormal_nose_morphology0.90896444
109MP0002090_abnormal_vision0.90243819
110MP0005174_abnormal_tail_pigmentation0.90172790
111MP0000639_abnormal_adrenal_gland0.89666019
112MP0002572_abnormal_emotion/affect_behav0.89638837
113MP0005636_abnormal_mineral_homeostasis0.88926803
114MP0000778_abnormal_nervous_system0.87855205
115MP0004215_abnormal_myocardial_fiber0.87465215
116MP0005085_abnormal_gallbladder_physiolo0.86882784
117MP0010678_abnormal_skin_adnexa0.85664400
118MP0003880_abnormal_central_pattern0.85636572
119MP0001986_abnormal_taste_sensitivity0.84098316
120MP0003119_abnormal_digestive_system0.83980392
121MP0010030_abnormal_orbit_morphology0.83365748
122MP0005503_abnormal_tendon_morphology0.83358673
123MP0002751_abnormal_autonomic_nervous0.82567079
124MP0001485_abnormal_pinna_reflex0.82128445
125MP0002138_abnormal_hepatobiliary_system0.81610617
126MP0002249_abnormal_larynx_morphology0.81415186
127MP0001188_hyperpigmentation0.81363482
128MP0002752_abnormal_somatic_nervous0.81280125
129MP0008775_abnormal_heart_ventricle0.81268175
130MP0004924_abnormal_behavior0.81237932
131MP0005386_behavior/neurological_phenoty0.81237932
132MP0008058_abnormal_DNA_repair0.81176531
133MP0003699_abnormal_female_reproductive0.79282402
134MP0001963_abnormal_hearing_physiology0.77185841
135MP0001177_atelectasis0.77011101
136MP0005410_abnormal_fertilization0.76587257
137MP0005220_abnormal_exocrine_pancreas0.75870668
138MP0001324_abnormal_eye_pigmentation0.75675844
139MP0000372_irregular_coat_pigmentation0.75471222
140MP0000163_abnormal_cartilage_morphology0.74317361
141MP0005332_abnormal_amino_acid0.73716800
142MP0000762_abnormal_tongue_morphology0.73017541
143MP0002102_abnormal_ear_morphology0.72957636
144MP0002736_abnormal_nociception_after0.70677182
145MP0002127_abnormal_cardiovascular_syste0.69542563

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.13265086
2Flat capital femoral epiphysis (HP:0003370)3.96479118
3Acute necrotizing encephalopathy (HP:0006965)3.82702362
4Abnormal mitochondria in muscle tissue (HP:0008316)3.48814297
5Medial flaring of the eyebrow (HP:0010747)3.42814686
6Increased serum pyruvate (HP:0003542)3.41179633
7Abnormality of glycolysis (HP:0004366)3.41179633
8Acute encephalopathy (HP:0006846)3.24930982
9Nephronophthisis (HP:0000090)3.20604715
10Irregular epiphyses (HP:0010582)3.15842717
11Abnormality of the labia minora (HP:0012880)3.15132365
12Congenital primary aphakia (HP:0007707)3.13719627
13Mitochondrial inheritance (HP:0001427)3.10287292
14Gait imbalance (HP:0002141)3.01870096
15Pancreatic fibrosis (HP:0100732)2.99297838
16Progressive macrocephaly (HP:0004481)2.98749271
17Type II lissencephaly (HP:0007260)2.97989973
18Nephrogenic diabetes insipidus (HP:0009806)2.95892730
19Stenosis of the external auditory canal (HP:0000402)2.94328746
20Increased CSF lactate (HP:0002490)2.93431903
21Increased hepatocellular lipid droplets (HP:0006565)2.91237024
22Vitreoretinal degeneration (HP:0000655)2.90507778
23Epiphyseal dysplasia (HP:0002656)2.84192122
24Renal Fanconi syndrome (HP:0001994)2.83605185
25Abnormality of the renal cortex (HP:0011035)2.81611485
26Lipid accumulation in hepatocytes (HP:0006561)2.81412817
27Poor coordination (HP:0002370)2.74629707
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72322542
29Abnormality of the renal medulla (HP:0100957)2.70477821
30Adrenal hypoplasia (HP:0000835)2.67782914
31Oligodactyly (hands) (HP:0001180)2.66499467
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.66340110
33Congenital stationary night blindness (HP:0007642)2.60807073
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54411597
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54411597
36Hyperventilation (HP:0002883)2.53263827
37Attenuation of retinal blood vessels (HP:0007843)2.51728935
38Delayed epiphyseal ossification (HP:0002663)2.48515673
39Breast hypoplasia (HP:0003187)2.48130605
40Birth length less than 3rd percentile (HP:0003561)2.45503526
41Short tibia (HP:0005736)2.44169485
42Bile duct proliferation (HP:0001408)2.41597904
43Abnormal biliary tract physiology (HP:0012439)2.41597904
44Hepatocellular necrosis (HP:0001404)2.40845879
45Autoamputation (HP:0001218)2.40324641
46Supernumerary spleens (HP:0009799)2.34984143
47Hypothermia (HP:0002045)2.31339068
48Genital tract atresia (HP:0001827)2.31124469
49Hepatic necrosis (HP:0002605)2.30709908
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30223653
51Cerebellar dysplasia (HP:0007033)2.29220022
52Sclerocornea (HP:0000647)2.28844392
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.25697424
54Hypoplasia of the fovea (HP:0007750)2.25697424
55Vaginal atresia (HP:0000148)2.25260319
56Methylmalonic aciduria (HP:0012120)2.24365962
57Cerebral hypomyelination (HP:0006808)2.21940737
58Hyperglycinemia (HP:0002154)2.21584213
59Cystic liver disease (HP:0006706)2.19788866
60Intestinal atresia (HP:0011100)2.16884564
61Lissencephaly (HP:0001339)2.16851469
62Septo-optic dysplasia (HP:0100842)2.16609949
63Optic disc pallor (HP:0000543)2.15431419
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14425817
65Chronic bronchitis (HP:0004469)2.13776064
66Renal cortical cysts (HP:0000803)2.11517896
67Anencephaly (HP:0002323)2.11416561
68Abnormality of the vertebral endplates (HP:0005106)2.09187288
69Enlarged kidneys (HP:0000105)2.09134230
70Abolished electroretinogram (ERG) (HP:0000550)2.08830645
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.08739559
72Abnormality of renal resorption (HP:0011038)2.07040780
73Tubular atrophy (HP:0000092)2.06948935
74Aplasia/Hypoplasia of the lens (HP:0008063)2.06010676
75Abnormal rod and cone electroretinograms (HP:0008323)2.05866196
76Gaze-evoked nystagmus (HP:0000640)2.04236125
77Optic nerve hypoplasia (HP:0000609)2.02945166
783-Methylglutaconic aciduria (HP:0003535)2.02938310
79Pendular nystagmus (HP:0012043)2.02493644
80Metaphyseal irregularity (HP:0003025)2.02360775
81Inability to walk (HP:0002540)2.02208611
82Abnormality of midbrain morphology (HP:0002418)2.01956746
83Molar tooth sign on MRI (HP:0002419)2.01956746
84Fair hair (HP:0002286)2.01753748
85True hermaphroditism (HP:0010459)2.01720650
86Abnormality of dentin (HP:0010299)2.01345164
87Postaxial foot polydactyly (HP:0001830)2.01322516
88Increased serum lactate (HP:0002151)2.00583244
89Lactic acidosis (HP:0003128)1.99772194
90Exercise intolerance (HP:0003546)1.99500464
91Abnormality of the fovea (HP:0000493)1.98466125
92Postaxial hand polydactyly (HP:0001162)1.98012820
93Cerebral edema (HP:0002181)1.97996545
94Tubulointerstitial nephritis (HP:0001970)1.97503610
95Genu varum (HP:0002970)1.96825294
96Abnormality of serum amino acid levels (HP:0003112)1.96338120
97Secondary amenorrhea (HP:0000869)1.96040468
98Congenital hepatic fibrosis (HP:0002612)1.96014078
99Metaphyseal dysplasia (HP:0100255)1.95906566
100Irregular vertebral endplates (HP:0003301)1.95488663
101Short femoral neck (HP:0100864)1.93473811
102Flattened epiphyses (HP:0003071)1.93321719
103Congenital sensorineural hearing impairment (HP:0008527)1.92205943
104Amniotic constriction ring (HP:0009775)1.92039518
105Abnormality of placental membranes (HP:0011409)1.92039518
106Renal tubular dysfunction (HP:0000124)1.91901994
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89839319
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89185541
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88724300
110Abnormality of alanine metabolism (HP:0010916)1.88724300
111Hyperalaninemia (HP:0003348)1.88724300
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.88235430
113Meckel diverticulum (HP:0002245)1.87898449
114Abnormality of urine glucose concentration (HP:0011016)1.87508511
115Glycosuria (HP:0003076)1.87508511
116Abnormality of methionine metabolism (HP:0010901)1.87445104
117Male pseudohermaphroditism (HP:0000037)1.86865960
118Severe muscular hypotonia (HP:0006829)1.86683912
119Abnormal protein glycosylation (HP:0012346)1.86568723
120Abnormal glycosylation (HP:0012345)1.86568723
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86568723
122Abnormal protein N-linked glycosylation (HP:0012347)1.86568723
123Dandy-Walker malformation (HP:0001305)1.85983829
124Furrowed tongue (HP:0000221)1.85289008
125Chorioretinal atrophy (HP:0000533)1.85288578
126Abnormality of vitamin B metabolism (HP:0004340)1.85269832
127Pachygyria (HP:0001302)1.84580254
128Abnormality of the ileum (HP:0001549)1.84553391
129Broad-based gait (HP:0002136)1.84533046
130Keratoconus (HP:0000563)1.84384581
131Increased corneal curvature (HP:0100692)1.84384581
132Bony spicule pigmentary retinopathy (HP:0007737)1.84287326
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83908302
134Chronic hepatic failure (HP:0100626)1.83664057
135Respiratory failure (HP:0002878)1.83077986
136Abnormal respiratory motile cilium physiology (HP:0012261)1.82505113
137Disproportionate short-trunk short stature (HP:0003521)1.82103922
138Abnormality of chromosome stability (HP:0003220)1.81805609
139Exertional dyspnea (HP:0002875)1.81745849
140Aplasia/hypoplasia of the uterus (HP:0008684)1.80071408
141Abnormality of the epiphysis of the femoral head (HP:0010574)1.79344581
142Preaxial hand polydactyly (HP:0001177)1.78540813
143Type I transferrin isoform profile (HP:0003642)1.78388539
144Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78219822
145Abnormality of femoral epiphyses (HP:0006499)1.78219822
146Median cleft lip (HP:0000161)1.77513030
147Facial cleft (HP:0002006)1.77372654
148Progressive inability to walk (HP:0002505)1.76457456
149Abnormal hair whorl (HP:0010721)1.76152860
150Carpal bone hypoplasia (HP:0001498)1.76111189
151Constricted visual fields (HP:0001133)1.75995135
152Leukodystrophy (HP:0002415)1.75823929
153Large for gestational age (HP:0001520)1.75799353
154Abnormality of incisor morphology (HP:0011063)1.75679115
155Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75002560
156Abnormality of the femoral head (HP:0003368)1.74670922
157Broad foot (HP:0001769)1.74078889
158Hyperphosphaturia (HP:0003109)1.73712060
159Abnormal hemoglobin (HP:0011902)1.73206112
160Cortical dysplasia (HP:0002539)1.73201642
161Methylmalonic acidemia (HP:0002912)1.71840285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.56185562
2PLK43.33708729
3SRPK12.73020396
4MAP4K22.66507268
5TRIM282.58003481
6ERBB42.56980746
7BMPR22.52569179
8STK38L2.44041587
9NME12.40371625
10PLK22.39108634
11AKT32.37126353
12CASK2.33659661
13INSRR2.21456660
14EIF2AK12.19095643
15CDK82.11938959
16BRAF1.97866909
17MST41.94052844
18EIF2AK31.92094664
19BUB11.85634205
20FRK1.82813037
21MAP2K71.79022791
22BCR1.73334384
23ZAK1.65857290
24MELK1.58036420
25BMPR1B1.52519265
26NEK61.51581767
27MAP3K61.48109736
28PAK31.44328500
29NEK11.42781874
30MUSK1.40327125
31PINK11.37472194
32STK161.31423695
33ARAF1.30809888
34STK241.28413745
35VRK11.28135159
36NUAK11.27641970
37MYLK1.26047399
38CSNK1G21.21289397
39TXK1.20810829
40DYRK21.19110737
41PLK31.12799280
42MAPK131.11070959
43MAP3K121.10651051
44TAOK31.10299660
45PRKD31.08902921
46ERBB31.07123070
47LATS11.06895132
48PIK3CA1.06651512
49STK31.06282952
50SGK21.06062466
51TRPM71.01391499
52TTK1.00189931
53WNK30.97218459
54PASK0.97146396
55OXSR10.96568804
56NLK0.95917160
57TGFBR10.94625054
58SGK4940.93535515
59SGK2230.93535515
60TLK10.93138900
61ADRBK20.92281321
62AURKA0.89444321
63EPHA40.86865435
64MARK10.86535624
65CAMKK20.86084102
66GRK10.85289451
67TIE10.84884106
68WEE10.84614279
69VRK20.83803780
70PDK20.81606517
71GRK70.78634612
72ACVR1B0.75632940
73CCNB10.73910255
74CHEK20.73841038
75TSSK60.71283545
76PLK10.70061370
77PRKCG0.69817966
78PRKCI0.66920177
79EIF2AK20.63719153
80MKNK20.63073891
81MET0.60620955
82PNCK0.58233619
83MAP3K140.55628007
84DAPK20.55110332
85CDC70.54683265
86MKNK10.53937701
87CSNK1G10.53302459
88KSR10.52836590
89NTRK20.52738959
90FER0.52539398
91MAPKAPK30.52406925
92MAP3K30.52005960
93FLT30.51545636
94MAP3K90.50916511
95CSNK2A10.50146891
96PTK2B0.49813137
97PRKCE0.49677863
98TEC0.47008490
99CSNK1A1L0.46928163
100MAP3K50.46355639
101CDK190.45834043
102MAP3K40.45476683
103LIMK10.45303153
104PRKG20.45241078
105TNIK0.44960207
106CSNK1G30.44910668
107ATM0.44182496
108ADRBK10.43903089
109RPS6KA50.43675819
110SIK30.43608450
111OBSCN0.43276485
112CSNK1A10.42874687
113STK390.42826266
114NTRK30.42577315
115ATR0.41741533
116AURKB0.41303965
117MAP2K40.40662211
118CSNK1D0.40661953
119CDK90.40583721
120DYRK1A0.39765628
121YES10.39674993
122MOS0.39639680
123BCKDK0.39620922
124CHUK0.38971354
125TNK20.38871272
126PDK40.38574518
127PDK30.38574518
128RPS6KB10.38006511
129PRKACA0.37394032
130TESK10.37126855
131CAMK2A0.36862196
132MAP2K10.36820780
133MAPK150.36167039
134WNK40.35832919
135CAMK2D0.34036903
136BRSK20.33853141
137PKN10.33038602
138GRK50.31808249
139NEK20.31391082
140PRKCQ0.31005437

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.51290898
2Proteasome_Homo sapiens_hsa030503.76709747
3Oxidative phosphorylation_Homo sapiens_hsa001903.40169365
4RNA polymerase_Homo sapiens_hsa030203.03948071
5Parkinsons disease_Homo sapiens_hsa050122.57593730
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26465880
7Huntingtons disease_Homo sapiens_hsa050162.17622138
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13066712
9Sulfur metabolism_Homo sapiens_hsa009202.12090990
10Alzheimers disease_Homo sapiens_hsa050101.97081624
11Basal transcription factors_Homo sapiens_hsa030221.89455647
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.79778422
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73459121
14Vitamin B6 metabolism_Homo sapiens_hsa007501.71591668
15Ribosome_Homo sapiens_hsa030101.68404024
16Phototransduction_Homo sapiens_hsa047441.67869180
17RNA degradation_Homo sapiens_hsa030181.63316744
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58055520
19Nicotine addiction_Homo sapiens_hsa050331.56517900
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55934412
21Pyrimidine metabolism_Homo sapiens_hsa002401.55017775
22Mismatch repair_Homo sapiens_hsa034301.54612198
23Homologous recombination_Homo sapiens_hsa034401.52546421
24Folate biosynthesis_Homo sapiens_hsa007901.52528351
25Nitrogen metabolism_Homo sapiens_hsa009101.51282735
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47668109
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46932425
28Linoleic acid metabolism_Homo sapiens_hsa005911.45073679
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39722316
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35658004
31Fatty acid elongation_Homo sapiens_hsa000621.32227296
32Vibrio cholerae infection_Homo sapiens_hsa051101.32079232
33Caffeine metabolism_Homo sapiens_hsa002321.31111579
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28145256
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27739099
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27430273
37Collecting duct acid secretion_Homo sapiens_hsa049661.26614603
38Peroxisome_Homo sapiens_hsa041461.26416074
39Retinol metabolism_Homo sapiens_hsa008301.25750400
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25052764
41Glutathione metabolism_Homo sapiens_hsa004801.24790960
42Arachidonic acid metabolism_Homo sapiens_hsa005901.22858466
43Purine metabolism_Homo sapiens_hsa002301.21966499
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20881307
45Chemical carcinogenesis_Homo sapiens_hsa052041.19096559
46Steroid biosynthesis_Homo sapiens_hsa001001.16124695
47Propanoate metabolism_Homo sapiens_hsa006401.15175906
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15124877
49Nucleotide excision repair_Homo sapiens_hsa034201.12623555
50RNA transport_Homo sapiens_hsa030131.11040631
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10969793
52Ether lipid metabolism_Homo sapiens_hsa005651.10313895
53Cell cycle_Homo sapiens_hsa041101.08063810
54Butanoate metabolism_Homo sapiens_hsa006501.05706900
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04903562
56Pyruvate metabolism_Homo sapiens_hsa006201.03377258
57Fanconi anemia pathway_Homo sapiens_hsa034601.01572420
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98639217
59Sphingolipid metabolism_Homo sapiens_hsa006000.97106981
60Ovarian steroidogenesis_Homo sapiens_hsa049130.96009512
61Tyrosine metabolism_Homo sapiens_hsa003500.95694033
62Base excision repair_Homo sapiens_hsa034100.93952431
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.93670253
64One carbon pool by folate_Homo sapiens_hsa006700.90148192
65Metabolic pathways_Homo sapiens_hsa011000.89470333
66Histidine metabolism_Homo sapiens_hsa003400.88679652
67Taste transduction_Homo sapiens_hsa047420.84277194
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82458493
69Regulation of autophagy_Homo sapiens_hsa041400.79118510
70Spliceosome_Homo sapiens_hsa030400.77857477
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77477804
72Olfactory transduction_Homo sapiens_hsa047400.76304116
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76137585
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75753061
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.73025940
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.70573628
77Morphine addiction_Homo sapiens_hsa050320.70333101
78Phenylalanine metabolism_Homo sapiens_hsa003600.68771752
79DNA replication_Homo sapiens_hsa030300.66766147
80Rheumatoid arthritis_Homo sapiens_hsa053230.66031937
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65852494
82Non-homologous end-joining_Homo sapiens_hsa034500.64984082
83Arginine and proline metabolism_Homo sapiens_hsa003300.64258596
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62882586
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61515678
86p53 signaling pathway_Homo sapiens_hsa041150.61187818
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60513011
88ABC transporters_Homo sapiens_hsa020100.60276273
89GABAergic synapse_Homo sapiens_hsa047270.59596272
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59044403
91Phagosome_Homo sapiens_hsa041450.56879933
92Vitamin digestion and absorption_Homo sapiens_hsa049770.56858101
93Selenocompound metabolism_Homo sapiens_hsa004500.56793401
94Oocyte meiosis_Homo sapiens_hsa041140.54647681
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54595363
96Fatty acid degradation_Homo sapiens_hsa000710.53786277
97TGF-beta signaling pathway_Homo sapiens_hsa043500.52687105
98Serotonergic synapse_Homo sapiens_hsa047260.51931395
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.51397518
100Tryptophan metabolism_Homo sapiens_hsa003800.49870532
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49171076
102Circadian rhythm_Homo sapiens_hsa047100.48283509
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46082400
104beta-Alanine metabolism_Homo sapiens_hsa004100.45037277
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43739206
106Sulfur relay system_Homo sapiens_hsa041220.43332307
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41484932
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41163399
109N-Glycan biosynthesis_Homo sapiens_hsa005100.38707851
110Glutamatergic synapse_Homo sapiens_hsa047240.37757692
111Mineral absorption_Homo sapiens_hsa049780.36794433
112Fatty acid metabolism_Homo sapiens_hsa012120.35540048
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34901289
114Autoimmune thyroid disease_Homo sapiens_hsa053200.34859502
115Cardiac muscle contraction_Homo sapiens_hsa042600.34618773
116Starch and sucrose metabolism_Homo sapiens_hsa005000.31622914
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30636354
118Fructose and mannose metabolism_Homo sapiens_hsa000510.25404117

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