SEC14L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52929790
2L-phenylalanine catabolic process (GO:0006559)7.52929790
3L-phenylalanine metabolic process (GO:0006558)7.19803033
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19803033
5aromatic amino acid family catabolic process (GO:0009074)6.83666471
6exogenous drug catabolic process (GO:0042738)6.55241195
7indole-containing compound catabolic process (GO:0042436)6.24412288
8indolalkylamine catabolic process (GO:0046218)6.24412288
9tryptophan catabolic process (GO:0006569)6.24412288
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18921839
11kynurenine metabolic process (GO:0070189)6.06953130
12bile acid biosynthetic process (GO:0006699)6.00148478
13tryptophan metabolic process (GO:0006568)5.85950528
14urea metabolic process (GO:0019627)5.65839856
15urea cycle (GO:0000050)5.65839856
16glyoxylate metabolic process (GO:0046487)5.63601946
17alpha-linolenic acid metabolic process (GO:0036109)5.57023058
18negative regulation of fibrinolysis (GO:0051918)5.55608169
19high-density lipoprotein particle remodeling (GO:0034375)5.47626462
20protein carboxylation (GO:0018214)5.45165425
21peptidyl-glutamic acid carboxylation (GO:0017187)5.45165425
22regulation of protein activation cascade (GO:2000257)5.38952912
23complement activation, alternative pathway (GO:0006957)5.38677742
24regulation of fibrinolysis (GO:0051917)5.38319293
25cysteine metabolic process (GO:0006534)5.29776552
26sulfur amino acid catabolic process (GO:0000098)5.25430214
27nitrogen cycle metabolic process (GO:0071941)5.20434234
28bile acid metabolic process (GO:0008206)5.11311405
29serine family amino acid catabolic process (GO:0009071)5.04853689
30regulation of complement activation (GO:0030449)5.03784613
31aromatic amino acid family metabolic process (GO:0009072)4.98412323
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91269302
33regulation of cholesterol esterification (GO:0010872)4.84209722
34regulation of triglyceride catabolic process (GO:0010896)4.82307906
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.80772456
36tyrosine metabolic process (GO:0006570)4.78988022
37homocysteine metabolic process (GO:0050667)4.76396979
38axonemal dynein complex assembly (GO:0070286)4.73317065
39reverse cholesterol transport (GO:0043691)4.71998195
40plasma lipoprotein particle remodeling (GO:0034369)4.67841355
41protein-lipid complex remodeling (GO:0034368)4.67841355
42macromolecular complex remodeling (GO:0034367)4.67841355
43alpha-amino acid catabolic process (GO:1901606)4.60807166
44amino-acid betaine metabolic process (GO:0006577)4.59419832
45phospholipid efflux (GO:0033700)4.57869889
46behavioral response to nicotine (GO:0035095)4.57850337
47acylglycerol homeostasis (GO:0055090)4.56517494
48triglyceride homeostasis (GO:0070328)4.56517494
49negative regulation of sterol transport (GO:0032372)4.53469273
50negative regulation of cholesterol transport (GO:0032375)4.53469273
51lysine catabolic process (GO:0006554)4.48755983
52lysine metabolic process (GO:0006553)4.48755983
53bile acid and bile salt transport (GO:0015721)4.42660339
54indolalkylamine metabolic process (GO:0006586)4.42326854
55coenzyme catabolic process (GO:0009109)4.36705125
56epithelial cilium movement (GO:0003351)4.36129639
57cellular biogenic amine catabolic process (GO:0042402)4.35750226
58amine catabolic process (GO:0009310)4.35750226
59imidazole-containing compound metabolic process (GO:0052803)4.34654441
60glycine metabolic process (GO:0006544)4.32124361
61cellular ketone body metabolic process (GO:0046950)4.30805576
62plasma lipoprotein particle clearance (GO:0034381)4.30571887
63cholesterol efflux (GO:0033344)4.26784385
64S-adenosylmethionine metabolic process (GO:0046500)4.23774934
65cellular glucuronidation (GO:0052695)4.23565118
66cellular amino acid catabolic process (GO:0009063)4.23027370
67cilium or flagellum-dependent cell motility (GO:0001539)4.21796787
68benzene-containing compound metabolic process (GO:0042537)4.19128651
69glutamate metabolic process (GO:0006536)4.15311480
70cilium movement (GO:0003341)4.15170832
71serine family amino acid metabolic process (GO:0009069)4.11804361
72ethanol oxidation (GO:0006069)4.10166454
73fibrinolysis (GO:0042730)4.02958780
74oxidative demethylation (GO:0070989)3.99949277
75cellular modified amino acid catabolic process (GO:0042219)3.99770598
76plasma lipoprotein particle assembly (GO:0034377)3.96983480
77arginine metabolic process (GO:0006525)3.96060823
78low-density lipoprotein particle remodeling (GO:0034374)3.93403216
79water-soluble vitamin biosynthetic process (GO:0042364)3.93041681
80serine family amino acid biosynthetic process (GO:0009070)3.89800920
81dicarboxylic acid biosynthetic process (GO:0043650)3.89414930
82drug catabolic process (GO:0042737)3.88908427
83very-low-density lipoprotein particle assembly (GO:0034379)3.88495092
84aldehyde catabolic process (GO:0046185)3.86699116
85omega-hydroxylase P450 pathway (GO:0097267)3.82921794
86regulation of bile acid biosynthetic process (GO:0070857)3.82317039
87complement activation, classical pathway (GO:0006958)3.81829495
88negative regulation of lipase activity (GO:0060192)3.81279693
89blood coagulation, intrinsic pathway (GO:0007597)3.80553908
90regulation of cilium movement (GO:0003352)3.79065119
91positive regulation of triglyceride lipase activity (GO:0061365)3.78142409
92positive regulation of lipoprotein lipase activity (GO:0051006)3.78142409
93complement activation (GO:0006956)3.77152578
94protein-cofactor linkage (GO:0018065)3.76887103
95glucuronate metabolic process (GO:0019585)3.76847784
96uronic acid metabolic process (GO:0006063)3.76847784
97cytolysis (GO:0019835)3.75920059
98positive regulation of lipid catabolic process (GO:0050996)3.75189300
99cholesterol homeostasis (GO:0042632)3.73674239
100L-fucose metabolic process (GO:0042354)3.73659568
101L-fucose catabolic process (GO:0042355)3.73659568
102fucose catabolic process (GO:0019317)3.73659568
103cofactor catabolic process (GO:0051187)3.73650271
104protein activation cascade (GO:0072376)3.73597599
105organic acid catabolic process (GO:0016054)3.72561015
106carboxylic acid catabolic process (GO:0046395)3.72561015
107ketone body metabolic process (GO:1902224)3.72488445
108phospholipid homeostasis (GO:0055091)3.69681803
109regulation of cholesterol homeostasis (GO:2000188)3.67468836
110sterol homeostasis (GO:0055092)3.67142085
111response to pheromone (GO:0019236)3.66987692
112axoneme assembly (GO:0035082)3.66043229
113epoxygenase P450 pathway (GO:0019373)3.65881659
114short-chain fatty acid metabolic process (GO:0046459)3.65460214
115acetyl-CoA metabolic process (GO:0006084)3.64141310
116plasma lipoprotein particle organization (GO:0071827)3.56681267
117drug metabolic process (GO:0017144)3.54784644
118response to nitrosative stress (GO:0051409)3.53663601
119NAD biosynthetic process (GO:0009435)3.53643741
120heme transport (GO:0015886)3.53396145
121positive regulation of fatty acid transport (GO:2000193)3.36933838
122alkaloid metabolic process (GO:0009820)3.31917475
123motile cilium assembly (GO:0044458)3.29061690
124amino acid salvage (GO:0043102)3.24091704
125L-methionine salvage (GO:0071267)3.24091704
126L-methionine biosynthetic process (GO:0071265)3.24091704
127DNA deamination (GO:0045006)3.21371504
128protoporphyrinogen IX biosynthetic process (GO:0006782)3.15422509
129nonmotile primary cilium assembly (GO:0035058)3.14340211
130organic cation transport (GO:0015695)3.13229697
131dopamine transport (GO:0015872)3.10486721
132protoporphyrinogen IX metabolic process (GO:0046501)3.09666153
133preassembly of GPI anchor in ER membrane (GO:0016254)3.04763666
134ethanol metabolic process (GO:0006067)3.03793374
135cornea development in camera-type eye (GO:0061303)3.01663838
136oxygen transport (GO:0015671)2.99482637
137positive regulation of icosanoid secretion (GO:0032305)2.96581536
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.94814912
139NADH dehydrogenase complex assembly (GO:0010257)2.94814912
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94814912
141tetrapyrrole biosynthetic process (GO:0033014)2.94065911
142pyrimidine nucleobase catabolic process (GO:0006208)2.90659820
143negative regulation of telomere maintenance (GO:0032205)2.89607312
144porphyrin-containing compound metabolic process (GO:0006778)2.89141690
145disruption of cells of other organism (GO:0044364)2.88684954
146killing of cells of other organism (GO:0031640)2.88684954
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87693663
148neurotransmitter metabolic process (GO:0042133)2.83584752
149regulation of microtubule-based movement (GO:0060632)2.83392116
150phenylpropanoid metabolic process (GO:0009698)2.79260195
151cilium organization (GO:0044782)2.78352866
152porphyrin-containing compound biosynthetic process (GO:0006779)2.72772367
153protein complex biogenesis (GO:0070271)2.71881071
154meiotic chromosome segregation (GO:0045132)2.70608714
155nucleobase catabolic process (GO:0046113)2.70462210
156cilium assembly (GO:0042384)2.69619481
157regulation of hexokinase activity (GO:1903299)2.69119354
158regulation of glucokinase activity (GO:0033131)2.69119354
159indole-containing compound metabolic process (GO:0042430)2.68227636
160cilium morphogenesis (GO:0060271)2.67243571
161peptidyl-glutamic acid modification (GO:0018200)2.66885309
162protein localization to cilium (GO:0061512)2.66274949
163methionine biosynthetic process (GO:0009086)2.66002465
164respiratory chain complex IV assembly (GO:0008535)2.63909486
165gas transport (GO:0015669)2.63506893
166protein polyglutamylation (GO:0018095)2.60556793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25962146
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09462742
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03487878
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.46042370
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31083308
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.08440227
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73602188
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04954360
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.93291736
10ZNF274_21170338_ChIP-Seq_K562_Hela3.89578205
11VDR_22108803_ChIP-Seq_LS180_Human3.62688373
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33724899
13IGF1R_20145208_ChIP-Seq_DFB_Human2.30802601
14GBX2_23144817_ChIP-Seq_PC3_Human2.16424697
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14966992
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03889531
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02885905
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01485088
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.01032393
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00698856
21* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7057612
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96928117
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94516011
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93088606
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.89905702
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88678228
27FUS_26573619_Chip-Seq_HEK293_Human1.85290837
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85128510
29ER_23166858_ChIP-Seq_MCF-7_Human1.84870867
30EWS_26573619_Chip-Seq_HEK293_Human1.83657525
31TP53_22573176_ChIP-Seq_HFKS_Human1.79956884
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72678668
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.63154008
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.60195757
35P300_19829295_ChIP-Seq_ESCs_Human1.58183944
36GATA1_22025678_ChIP-Seq_K562_Human1.57258836
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.56908455
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56908455
39HTT_18923047_ChIP-ChIP_STHdh_Human1.55880168
40MYC_18940864_ChIP-ChIP_HL60_Human1.55296643
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.51281934
42CLOCK_20551151_ChIP-Seq_293T_Human1.51215874
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49492374
44EZH2_22144423_ChIP-Seq_EOC_Human1.48562601
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.47315610
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46464540
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44401382
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.43487936
49NCOR_22424771_ChIP-Seq_293T_Human1.43039352
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42368334
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41405539
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.41397799
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37448724
54SOX2_19829295_ChIP-Seq_ESCs_Human1.36558569
55NANOG_19829295_ChIP-Seq_ESCs_Human1.36558569
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36151066
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35561461
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34255352
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34255352
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32400266
61STAT3_23295773_ChIP-Seq_U87_Human1.30432662
62ERA_21632823_ChIP-Seq_H3396_Human1.27772270
63TCF4_23295773_ChIP-Seq_U87_Human1.27145883
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26568412
65HOXB7_26014856_ChIP-Seq_BT474_Human1.25429146
66* NANOG_20526341_ChIP-Seq_ESCs_Human1.24967287
67REST_21632747_ChIP-Seq_MESCs_Mouse1.24460559
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24216121
69AR_25329375_ChIP-Seq_VCAP_Human1.23441941
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21681001
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21118471
72CBP_20019798_ChIP-Seq_JUKART_Human1.21118471
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20973378
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.20457283
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20246643
76TCF4_22108803_ChIP-Seq_LS180_Human1.18988957
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.18887633
78MYC_19829295_ChIP-Seq_ESCs_Human1.18836633
79* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16919479
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16421020
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16251838
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15632873
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15011702
84OCT4_20526341_ChIP-Seq_ESCs_Human1.10937764
85VDR_23849224_ChIP-Seq_CD4+_Human1.10839649
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09923849
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09489531
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09118799
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08109529
90SMAD4_21799915_ChIP-Seq_A2780_Human1.07866242
91RUNX2_22187159_ChIP-Seq_PCA_Human1.06792576
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.06471661
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05425665
94* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04768927
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04506135
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04059837
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03752648
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03537736
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03294778
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01605077
101GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00417521
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00372669
103PHF8_20622853_ChIP-Seq_HELA_Human1.00005453
104* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99601347
105AR_21572438_ChIP-Seq_LNCaP_Human0.99063010
106ETV1_20927104_ChIP-Seq_GIST48_Human0.98792720
107ETS1_20019798_ChIP-Seq_JURKAT_Human0.97112723
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96391866
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96389614
110FOXH1_21741376_ChIP-Seq_ESCs_Human0.96016255
111CRX_20693478_ChIP-Seq_RETINA_Mouse0.92653181
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91166922
113GATA4_25053715_ChIP-Seq_YYC3_Human0.90892836
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.87556384
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86791547
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85981790
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85857845
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84421501
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.81020215
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78923255
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75788404
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72524823
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72282087
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71777976
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69896041
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69252810
127* RARA_24833708_ChIP-Seq_LIVER_Mouse0.68796412
128ZNF263_19887448_ChIP-Seq_K562_Human0.68180804
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67146732
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67146732
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66387507
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.64023027
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63886562
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63457799
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63184756
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.62455142
137CEBPB_22108803_ChIP-Seq_LS180_Human0.61805353
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59368591
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57984911
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.56680585
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.55333401
142EGR1_19032775_ChIP-ChIP_M12_Human0.55174010
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.54572702
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.54029220
145TAF15_26573619_Chip-Seq_HEK293_Human0.53112847
146* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53040564
147AR_20517297_ChIP-Seq_VCAP_Human0.52856268
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.52156411
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52006070
150STAT1_17558387_ChIP-Seq_HELA_Human0.51433752
151CBP_21632823_ChIP-Seq_H3396_Human0.50888221
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50887601
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.50811581
154MYC_19915707_ChIP-ChIP_AK7_Human0.49908029
155NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.48873994
156LXR_22292898_ChIP-Seq_THP-1_Human0.48159193
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47752922
158E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.47638078
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46788262
160PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46418842
161FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45821578
162BCAT_22108803_ChIP-Seq_LS180_Human0.45752399
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.45170586
164* P53_21459846_ChIP-Seq_SAOS-2_Human0.44507781
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44116563
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43067393
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42505459
168* GATA6_25053715_ChIP-Seq_YYC3_Human0.42145426
169STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41905726
170TAF2_19829295_ChIP-Seq_ESCs_Human0.41444237
171* SOX2_20726797_ChIP-Seq_SW620_Human0.41419682
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.41185773
173* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40862002
174ERG_21242973_ChIP-ChIP_JURKAT_Human0.40482287
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39620126
176CDX2_22108803_ChIP-Seq_LS180_Human0.39268542
177MYC_27129775_Chip-Seq_CORNEA_Mouse0.38095562
178IRF1_19129219_ChIP-ChIP_H3396_Human0.38026572
179SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37703937
180FOXH1_21741376_ChIP-Seq_EPCs_Human0.36917893
181GATA1_19941826_ChIP-Seq_K562_Human0.35008588
182P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34539236
183* GATA2_19941826_ChIP-Seq_K562_Human0.34220455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.26903986
2MP0005360_urolithiasis7.31831361
3MP0005085_abnormal_gallbladder_physiolo6.51176898
4MP0005365_abnormal_bile_salt6.25588207
5MP0004147_increased_porphyrin_level5.13648224
6MP0008875_abnormal_xenobiotic_pharmacok5.08022804
7MP0003806_abnormal_nucleotide_metabolis4.12408205
8MP0003252_abnormal_bile_duct3.83708540
9MP0010329_abnormal_lipoprotein_level3.54645071
10MP0005083_abnormal_biliary_tract3.37032346
11MP0009840_abnormal_foam_cell3.19550376
12MP0003195_calcinosis2.73690629
13MP0001666_abnormal_nutrient_absorption2.72732090
14MP0005332_abnormal_amino_acid2.69393822
15MP0003646_muscle_fatigue2.40830103
16MP0003191_abnormal_cellular_cholesterol2.34329607
17MP0002837_dystrophic_cardiac_calcinosis2.15728125
18MP0002653_abnormal_ependyma_morphology2.14580090
19MP0005551_abnormal_eye_electrophysiolog2.13261472
20MP0000609_abnormal_liver_physiology2.12565396
21MP0004019_abnormal_vitamin_homeostasis2.12077255
22MP0002118_abnormal_lipid_homeostasis2.11626037
23MP0003136_yellow_coat_color2.10799497
24MP0002138_abnormal_hepatobiliary_system2.03708927
25MP0004133_heterotaxia1.99829472
26MP0003868_abnormal_feces_composition1.91013777
27MP0006292_abnormal_olfactory_placode1.87582786
28MP0008877_abnormal_DNA_methylation1.87205800
29MP0004142_abnormal_muscle_tone1.80418258
30MP0001968_abnormal_touch/_nociception1.80035984
31MP0005319_abnormal_enzyme/_coenzyme1.77165138
32MP0004885_abnormal_endolymph1.74017783
33MP0005645_abnormal_hypothalamus_physiol1.70700114
34MP0001986_abnormal_taste_sensitivity1.68050642
35MP0004043_abnormal_pH_regulation1.66623381
36MP0001764_abnormal_homeostasis1.62439291
37MP0009697_abnormal_copulation1.57477302
38MP0002736_abnormal_nociception_after1.55769009
39MP0005377_hearing/vestibular/ear_phenot1.51916067
40MP0003878_abnormal_ear_physiology1.51916067
41MP0000372_irregular_coat_pigmentation1.49520135
42MP0005584_abnormal_enzyme/coenzyme_acti1.48824352
43MP0005451_abnormal_body_composition1.48312178
44MP0002638_abnormal_pupillary_reflex1.45567171
45MP0005646_abnormal_pituitary_gland1.43891625
46MP0009046_muscle_twitch1.40847450
47MP0009745_abnormal_behavioral_response1.39680884
48MP0003011_delayed_dark_adaptation1.39143848
49MP0001529_abnormal_vocalization1.35923936
50MP0005253_abnormal_eye_physiology1.30612905
51MP0001984_abnormal_olfaction1.29820485
52MP0006072_abnormal_retinal_apoptosis1.29608532
53MP0005647_abnormal_sex_gland1.22572074
54MP0009643_abnormal_urine_homeostasis1.21134231
55MP0002163_abnormal_gland_morphology1.21084202
56MP0003186_abnormal_redox_activity1.19890836
57MP0005075_abnormal_melanosome_morpholog1.19150252
58MP0006276_abnormal_autonomic_nervous1.18607529
59MP0002272_abnormal_nervous_system1.17644506
60MP0003705_abnormal_hypodermis_morpholog1.16517828
61MP0002160_abnormal_reproductive_system1.15272652
62MP0000598_abnormal_liver_morphology1.12493475
63MP0008789_abnormal_olfactory_epithelium1.12069283
64MP0001485_abnormal_pinna_reflex1.11501089
65MP0002254_reproductive_system_inflammat1.11456158
66MP0002102_abnormal_ear_morphology1.11063025
67MP0009764_decreased_sensitivity_to1.07395930
68MP0000569_abnormal_digit_pigmentation1.06499574
69MP0008775_abnormal_heart_ventricle1.05849307
70MP0003656_abnormal_erythrocyte_physiolo1.05822509
71MP0004782_abnormal_surfactant_physiolog1.03702311
72MP0010368_abnormal_lymphatic_system1.01678583
73MP0000604_amyloidosis1.00155180
74MP0005379_endocrine/exocrine_gland_phen0.99282152
75MP0005174_abnormal_tail_pigmentation0.99185244
76MP0001905_abnormal_dopamine_level0.97842345
77MP0009763_increased_sensitivity_to0.97675672
78MP0002735_abnormal_chemical_nociception0.97057256
79MP0002095_abnormal_skin_pigmentation0.96907980
80MP0000631_abnormal_neuroendocrine_gland0.94739510
81MP0004145_abnormal_muscle_electrophysio0.92236089
82MP0005389_reproductive_system_phenotype0.92183435
83MP0003890_abnormal_embryonic-extraembry0.90973983
84MP0005636_abnormal_mineral_homeostasis0.89817784
85MP0005408_hypopigmentation0.89244341
86MP0004742_abnormal_vestibular_system0.89119933
87MP0005195_abnormal_posterior_eye0.89083905
88MP0008469_abnormal_protein_level0.86938152
89MP0008995_early_reproductive_senescence0.86530384
90MP0002938_white_spotting0.86080409
91MP0001501_abnormal_sleep_pattern0.85204964
92MP0005084_abnormal_gallbladder_morpholo0.84735608
93MP0009642_abnormal_blood_homeostasis0.84362520
94MP0005670_abnormal_white_adipose0.83149602
95MP0002557_abnormal_social/conspecific_i0.81118614
96MP0005220_abnormal_exocrine_pancreas0.80894355
97MP0008058_abnormal_DNA_repair0.80106690
98MP0001970_abnormal_pain_threshold0.79633683
99MP0005187_abnormal_penis_morphology0.79238755
100MP0001486_abnormal_startle_reflex0.77746676
101MP0002064_seizures0.76923123
102MP0009765_abnormal_xenobiotic_induced0.76770127
103MP0002572_abnormal_emotion/affect_behav0.75858197
104MP0003698_abnormal_male_reproductive0.75731737
105MP0005376_homeostasis/metabolism_phenot0.74889259
106MP0000383_abnormal_hair_follicle0.73873902
107MP0002078_abnormal_glucose_homeostasis0.73521064
108MP0001188_hyperpigmentation0.73232387
109MP0006036_abnormal_mitochondrial_physio0.72963200
110MP0005410_abnormal_fertilization0.71376642
111MP0002796_impaired_skin_barrier0.71258614
112MP0002971_abnormal_brown_adipose0.70448057
113MP0002229_neurodegeneration0.70341388
114MP0001929_abnormal_gametogenesis0.70193599
115MP0005499_abnormal_olfactory_system0.70002539
116MP0005394_taste/olfaction_phenotype0.70002539
117MP0002876_abnormal_thyroid_physiology0.69522412
118MP0004381_abnormal_hair_follicle0.69405823
119MP0005334_abnormal_fat_pad0.68801580
120MP0005423_abnormal_somatic_nervous0.67688312
121MP0002909_abnormal_adrenal_gland0.67598106
122MP0001324_abnormal_eye_pigmentation0.67261951
123MP0003690_abnormal_glial_cell0.66306223
124MP0009053_abnormal_anal_canal0.63464307
125MP0004130_abnormal_muscle_cell0.62802965
126MP0005535_abnormal_body_temperature0.62225321
127MP0001661_extended_life_span0.61309632
128MP0003329_amyloid_beta_deposits0.59325086
129MP0000579_abnormal_nail_morphology0.59185562
130MP0000639_abnormal_adrenal_gland0.58965890
131MP0003724_increased_susceptibility_to0.57545867
132MP0005266_abnormal_metabolism0.56629007
133MP0001756_abnormal_urination0.55694277
134MP0005448_abnormal_energy_balance0.54381614
135MP0006035_abnormal_mitochondrial_morpho0.51383346
136MP0005464_abnormal_platelet_physiology0.48685251
137MP0003718_maternal_effect0.48343886
138MP0005395_other_phenotype0.48174392
139MP0003638_abnormal_response/metabolism_0.47393297
140MP0002136_abnormal_kidney_physiology0.44187127
141MP0002928_abnormal_bile_duct0.43934128
142MP0008874_decreased_physiological_sensi0.41005779
143MP0002822_catalepsy0.40721085
144MP0003436_decreased_susceptibility_to0.40689384
145MP0008873_increased_physiological_sensi0.39852875
146MP0005248_abnormal_Harderian_gland0.39843695
147MP0002060_abnormal_skin_morphology0.39548323
148MP0003953_abnormal_hormone_level0.38846967
149MP0009384_cardiac_valve_regurgitation0.37889993
150MP0005666_abnormal_adipose_tissue0.37656234
151MP0001243_abnormal_dermal_layer0.37258508
152MP0005166_decreased_susceptibility_to0.37249481
153MP0002132_abnormal_respiratory_system0.36637695
154MP0000427_abnormal_hair_cycle0.36368850
155MP0003075_altered_response_to0.35554910
156MP0003453_abnormal_keratinocyte_physiol0.34421652
157MP0004883_abnormal_blood_vessel0.31913853
158MP0009672_abnormal_birth_weight0.31860926
159MP0008872_abnormal_physiological_respon0.31619096
160MP0009115_abnormal_fat_cell0.31246822
161MP0001881_abnormal_mammary_gland0.30542227
162MP0002168_other_aberrant_phenotype0.29719140
163MP0000249_abnormal_blood_vessel0.29224396
164MP0010234_abnormal_vibrissa_follicle0.29072236
165MP0000647_abnormal_sebaceous_gland0.28280588
166MP0000230_abnormal_systemic_arterial0.27665386
167MP0001853_heart_inflammation0.27431600
168MP0002970_abnormal_white_adipose0.27394719
169MP0002295_abnormal_pulmonary_circulatio0.27041730

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.41318157
2Intrahepatic cholestasis (HP:0001406)7.40776025
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37727721
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.77653421
5Prolonged partial thromboplastin time (HP:0003645)6.70847993
6Hypobetalipoproteinemia (HP:0003563)6.34307734
7Xanthomatosis (HP:0000991)6.27001208
8Complement deficiency (HP:0004431)5.56073481
9Hyperlipoproteinemia (HP:0010980)5.54116582
10Joint hemorrhage (HP:0005261)4.88044968
11Hypolipoproteinemia (HP:0010981)4.73289116
12Epidermoid cyst (HP:0200040)4.62097323
13Hyperammonemia (HP:0001987)4.55529045
14Abnormality of the common coagulation pathway (HP:0010990)4.53771710
15Hyperglycinemia (HP:0002154)4.49424736
16Pancreatic cysts (HP:0001737)4.44184223
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34829499
18Pancreatic fibrosis (HP:0100732)4.31795161
19True hermaphroditism (HP:0010459)4.31120223
20Abnormality of methionine metabolism (HP:0010901)4.30279704
21Fat malabsorption (HP:0002630)4.26687541
22Dynein arm defect of respiratory motile cilia (HP:0012255)4.23172703
23Absent/shortened dynein arms (HP:0200106)4.23172703
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.22793018
25Ketosis (HP:0001946)4.20402874
26Abnormal respiratory epithelium morphology (HP:0012253)4.16567279
27Abnormal respiratory motile cilium morphology (HP:0005938)4.16567279
28Hypoalphalipoproteinemia (HP:0003233)4.14322417
29Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11889593
30Abnormality of midbrain morphology (HP:0002418)4.08899214
31Molar tooth sign on MRI (HP:0002419)4.08899214
32Abnormality of complement system (HP:0005339)4.05798524
33Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05021356
34Hyperglycinuria (HP:0003108)3.96098629
35Abnormality of serine family amino acid metabolism (HP:0010894)3.93397720
36Abnormality of glycine metabolism (HP:0010895)3.93397720
37Abnormality of pyrimidine metabolism (HP:0004353)3.91901954
38Hypoglycemic coma (HP:0001325)3.89916902
39Conjugated hyperbilirubinemia (HP:0002908)3.85286368
40Abnormality of the intrinsic pathway (HP:0010989)3.83897845
41Abnormal ciliary motility (HP:0012262)3.73110807
42Abnormality of the heme biosynthetic pathway (HP:0010472)3.70283362
43Hypercholesterolemia (HP:0003124)3.60786626
44Abnormal respiratory motile cilium physiology (HP:0012261)3.58998513
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.56513707
46Nephronophthisis (HP:0000090)3.49392047
47Congenital stationary night blindness (HP:0007642)3.44522867
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34226002
49Abnormality of fatty-acid metabolism (HP:0004359)3.29731331
50Steatorrhea (HP:0002570)3.28676317
51Hyperbilirubinemia (HP:0002904)3.27204884
52Chronic hepatic failure (HP:0100626)3.16318434
53Abnormality of nucleobase metabolism (HP:0010932)3.11762129
54Delayed CNS myelination (HP:0002188)3.10516157
55Rhinitis (HP:0012384)3.10394794
56Medial flaring of the eyebrow (HP:0010747)3.07985065
57Abnormality of the renal medulla (HP:0100957)3.07759296
58Abnormality of serum amino acid levels (HP:0003112)3.06389970
59Spontaneous abortion (HP:0005268)3.05958376
60Cystic liver disease (HP:0006706)3.04100475
61Ketoacidosis (HP:0001993)2.98908519
62Myocardial infarction (HP:0001658)2.98660327
63Hypochromic microcytic anemia (HP:0004840)2.95385530
64Abnormality of the renal cortex (HP:0011035)2.93508403
65Hepatocellular carcinoma (HP:0001402)2.91744130
66Decreased central vision (HP:0007663)2.82599525
67Skin nodule (HP:0200036)2.78176656
68Type II lissencephaly (HP:0007260)2.75271575
69Systemic lupus erythematosus (HP:0002725)2.74863384
70Tubular atrophy (HP:0000092)2.71968202
71Abnormality of purine metabolism (HP:0004352)2.71692217
72Metabolic acidosis (HP:0001942)2.71528020
73Gait imbalance (HP:0002141)2.65320925
74Gout (HP:0001997)2.63215744
75Vascular calcification (HP:0004934)2.62155848
76Attenuation of retinal blood vessels (HP:0007843)2.60853073
77Congenital primary aphakia (HP:0007707)2.58185048
78Lethargy (HP:0001254)2.56946448
79Nephrogenic diabetes insipidus (HP:0009806)2.55149274
80Sclerocornea (HP:0000647)2.53558435
81Hypoglycemic seizures (HP:0002173)2.53548705
82Pendular nystagmus (HP:0012043)2.53059427
83Dicarboxylic aciduria (HP:0003215)2.51760169
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51760169
85Occipital encephalocele (HP:0002085)2.46251121
86Glomerulonephritis (HP:0000099)2.45054583
87Spastic diplegia (HP:0001264)2.44375824
88Recurrent gram-negative bacterial infections (HP:0005420)2.44158507
89Abnormality of alanine metabolism (HP:0010916)2.44006585
90Hyperalaninemia (HP:0003348)2.44006585
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44006585
92Abolished electroretinogram (ERG) (HP:0000550)2.43750765
93Acanthocytosis (HP:0001927)2.43265060
94Anencephaly (HP:0002323)2.41800591
95Mitral stenosis (HP:0001718)2.40469179
96Cerebral edema (HP:0002181)2.37941314
97Abnormal gallbladder morphology (HP:0012437)2.34721259
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.33900408
99Neonatal onset (HP:0003623)2.33284860
100Abnormal rod and cone electroretinograms (HP:0008323)2.32935818
101Acute encephalopathy (HP:0006846)2.32048597
1023-Methylglutaconic aciduria (HP:0003535)2.31790079
103Cardiovascular calcification (HP:0011915)2.31094634
104Irritability (HP:0000737)2.30597685
105Amyloidosis (HP:0011034)2.30531665
106Bile duct proliferation (HP:0001408)2.30438318
107Abnormal biliary tract physiology (HP:0012439)2.30438318
108Congenital hepatic fibrosis (HP:0002612)2.28460534
109Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28311825
110Cholelithiasis (HP:0001081)2.28075207
111Acute necrotizing encephalopathy (HP:0006965)2.26829660
112Postaxial foot polydactyly (HP:0001830)2.26796313
113Esophageal varix (HP:0002040)2.25639981
114Malnutrition (HP:0004395)2.22596499
115Male pseudohermaphroditism (HP:0000037)2.21824131
116Gingival bleeding (HP:0000225)2.19804365
117Brushfield spots (HP:0001088)2.18716313
118Cholecystitis (HP:0001082)2.16281330
119Abnormal gallbladder physiology (HP:0012438)2.16281330
120Sensorimotor neuropathy (HP:0007141)2.15688067
121Late onset (HP:0003584)2.15639387
122Pancreatitis (HP:0001733)2.15498964
123Menorrhagia (HP:0000132)2.13799683
124Mitochondrial inheritance (HP:0001427)2.13576587
125Abnormal drinking behavior (HP:0030082)2.13374157
126Polydipsia (HP:0001959)2.13374157
127Furrowed tongue (HP:0000221)2.12732913
128Abnormal number of erythroid precursors (HP:0012131)2.07410898
129Hyperinsulinemic hypoglycemia (HP:0000825)2.07039720
130Thrombophlebitis (HP:0004418)2.06663240
131Bronchiectasis (HP:0002110)2.04961309
132Chronic bronchitis (HP:0004469)2.04760751
133Opisthotonus (HP:0002179)2.03931728
134Hypochromic anemia (HP:0001931)2.03645325
135Enlarged kidneys (HP:0000105)2.03091101
136Vomiting (HP:0002013)2.03084244
137Increased CSF lactate (HP:0002490)2.02556990
138Methylmalonic acidemia (HP:0002912)2.02297347
139Rickets (HP:0002748)2.01029836
140Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00252544
141Hemorrhage of the eye (HP:0011885)1.99482224
142Genital tract atresia (HP:0001827)1.99427355
143Generalized aminoaciduria (HP:0002909)1.98636238
144Abnormal hemoglobin (HP:0011902)1.95479401
145Poor coordination (HP:0002370)1.95110927
146Progressive macrocephaly (HP:0004481)1.94242714
147Chorioretinal atrophy (HP:0000533)1.93492897
148Abnormality of the gallbladder (HP:0005264)1.93348313
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.92971536
150Vaginal atresia (HP:0000148)1.92525749
151Poikilocytosis (HP:0004447)1.92076296
152Cerebellar dysplasia (HP:0007033)1.91246397
153Concave nail (HP:0001598)1.90455842
154Abnormality of iron homeostasis (HP:0011031)1.90147503
155Abnormality of transition element cation homeostasis (HP:0011030)1.89629091
156Renal cortical cysts (HP:0000803)1.89426429
157Hypophosphatemic rickets (HP:0004912)1.89221693
158Abnormal mitochondria in muscle tissue (HP:0008316)1.88980667
159Abnormal cartilage morphology (HP:0002763)1.88370973
160Lipid accumulation in hepatocytes (HP:0006561)1.87285386
161Large for gestational age (HP:0001520)1.85061289
162Microcytic anemia (HP:0001935)1.84608801
163Polyuria (HP:0000103)1.83680822
164Nephritis (HP:0000123)1.82075727
165Abnormal enzyme/coenzyme activity (HP:0012379)1.81825103
166Fair hair (HP:0002286)1.81597081
167Optic disc pallor (HP:0000543)1.81087766
168Alkalosis (HP:0001948)1.80903026
169Hyperventilation (HP:0002883)1.80475828
170Hyperglycemia (HP:0003074)1.80176333
171Elevated hepatic transaminases (HP:0002910)1.79481520
172Decreased circulating renin level (HP:0003351)1.77905062
173Inability to walk (HP:0002540)1.77668337
174Lissencephaly (HP:0001339)1.77076832
175Progressive inability to walk (HP:0002505)1.76190058
176Hepatocellular necrosis (HP:0001404)1.75795073
177Hydroxyprolinuria (HP:0003080)1.75678096
178Abnormality of proline metabolism (HP:0010907)1.75678096
179Abnormality of vitamin metabolism (HP:0100508)1.75369133
180Dyskinesia (HP:0100660)1.75125920
181Abnormality of urine glucose concentration (HP:0011016)1.74693445
182Glycosuria (HP:0003076)1.74693445
183Asplenia (HP:0001746)1.74346289
184Methylmalonic aciduria (HP:0012120)1.74273119
185Increased purine levels (HP:0004368)1.71710769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.89455192
2FGFR44.53502303
3SIK14.50365385
4ERN14.49333515
5TLK13.57605709
6ZAK3.44994392
7ADRBK23.39110102
8TAOK33.22596666
9INSRR3.14935078
10MAP4K23.03985906
11ERBB42.97874460
12BMPR1B2.87290590
13WNK42.52841806
14MST1R2.47054897
15WNK32.26456514
16ACVR1B2.19465798
17MAP2K42.17843669
18PIK3CG2.17122093
19NUAK12.13877641
20FGFR21.96498007
21TAF11.85895420
22LATS11.83781685
23MAPK111.82696907
24MST41.82437100
25TXK1.79495643
26OXSR11.77048494
27DYRK21.74640757
28PKN21.74502021
29DAPK21.71303463
30FLT31.68922667
31TYK21.63966041
32STK391.47635809
33PTK61.45314614
34MAPK131.41824748
35MAP3K41.40040975
36ADRBK11.35527643
37ABL21.35010726
38TRIB31.34486214
39STK161.32004467
40NEK91.30719506
41FRK1.26529187
42MAPK151.24844400
43KDR1.17456052
44CASK1.17046151
45PTK2B1.15775399
46MAP3K31.15299723
47JAK21.14384369
48MAP3K71.12001424
49TBK11.11439576
50PRKAA21.10938418
51MAP2K71.09158444
52ERBB21.08444575
53MAPKAPK51.06841706
54STK111.05219974
55MAP3K141.02093657
56PINK10.99746644
57BCR0.97751317
58MAPK40.97042885
59EPHB10.96311302
60MET0.96142406
61PAK30.95839428
62TIE10.95188012
63EPHA30.94736731
64JAK10.94509010
65MAP2K30.94214806
66TGFBR10.92040652
67NME10.91629805
68STK38L0.90959796
69RPS6KA50.89721871
70GRK60.89057614
71PRKCZ0.88056659
72CDK60.86735403
73NEK20.85749889
74TRIM280.85538108
75PHKG20.83750585
76PHKG10.83750585
77MKNK10.83380257
78VRK20.83178325
79IRAK30.82570976
80BRSK20.82346213
81PRKCI0.80357330
82PLK40.79710336
83MAP3K110.78676767
84IKBKB0.76957330
85PLK30.75335973
86DYRK1B0.75265534
87VRK10.74925370
88MAPK120.74391084
89MKNK20.73413621
90PRKACG0.73390295
91CAMK2G0.72980581
92EIF2AK10.72429443
93GSK3A0.72279068
94TGFBR20.72228461
95GRK10.71483651
96DYRK30.70265644
97MAP2K60.69121043
98CSK0.68946490
99CAMK1D0.68624334
100PRKCE0.68091413
101TNIK0.66117382
102SIK20.65844713
103MAP3K100.65732891
104IKBKE0.65310069
105PLK10.65179470
106MAPKAPK30.63845129
107PKN10.60716729
108STK30.60545098
109MAPK70.60231416
110PRKAA10.59849827
111CAMKK20.59671588
112FGFR30.56935293
113SGK30.56614890
114MUSK0.56099230
115RIPK10.55301465
116PRKACA0.53819660
117NTRK30.53212211
118NTRK20.52290768
119TEC0.51940879
120PRKCQ0.50926628
121PTK20.50546815
122NLK0.50081271
123CSNK1G10.47523581
124IGF1R0.47257755
125PDPK10.46651945
126TRPM70.44416369
127EPHA20.43934738
128SGK20.43149395
129MAP2K10.42605386
130RPS6KA60.42104671
131IRAK10.41928592
132CSNK1G30.41920090
133ATR0.41359337
134STK240.41277406
135CHEK20.41001331
136CSF1R0.40506921
137EPHA40.40327294
138CAMK2A0.37581273
139ICK0.37384673
140TAOK20.36760522
141MAP2K20.36729141
142TNK20.36530340
143EGFR0.35807627
144CSNK1D0.35327785
145PBK0.34693883
146MAP3K60.33883204
147CSNK1A10.33753859
148FER0.33335249
149CHUK0.33098420
150MAP3K50.32942872
151KIT0.32797370
152PIM10.32357233
153EPHB20.31890152
154MTOR0.31870989
155PRKCG0.30833470
156IRAK20.30594564
157CDK40.30106969
158PIK3CA0.29590499
159MAP3K10.28685888
160RET0.28316957
161SGK2230.28303993
162SGK4940.28303993
163ZAP700.27470968
164LATS20.26355286
165PRKCA0.26113015
166ABL10.25989242
167MAP3K130.25220603
168FGFR10.24626634
169CAMK40.23764821
170CSNK1G20.23543468

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.58023409
2Nitrogen metabolism_Homo sapiens_hsa009103.47430287
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31273671
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29904273
5Arginine biosynthesis_Homo sapiens_hsa002203.01497626
6Complement and coagulation cascades_Homo sapiens_hsa046102.77349237
7Tryptophan metabolism_Homo sapiens_hsa003802.72830543
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67882076
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56979634
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53192982
11Fatty acid degradation_Homo sapiens_hsa000712.48104273
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38360677
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24735445
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23353513
15Peroxisome_Homo sapiens_hsa041462.10040446
16Butanoate metabolism_Homo sapiens_hsa006502.09761339
17Chemical carcinogenesis_Homo sapiens_hsa052042.01705600
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01142484
19Histidine metabolism_Homo sapiens_hsa003401.99138956
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.94487574
21Propanoate metabolism_Homo sapiens_hsa006401.93318984
22PPAR signaling pathway_Homo sapiens_hsa033201.87776781
23Fatty acid metabolism_Homo sapiens_hsa012121.79971160
24Caffeine metabolism_Homo sapiens_hsa002321.77271927
25Staphylococcus aureus infection_Homo sapiens_hsa051501.76987605
26beta-Alanine metabolism_Homo sapiens_hsa004101.76527139
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.75485375
28Retinol metabolism_Homo sapiens_hsa008301.74974817
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74643195
30Oxidative phosphorylation_Homo sapiens_hsa001901.69727068
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69033373
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68870081
33Phototransduction_Homo sapiens_hsa047441.66017615
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65143613
35Phenylalanine metabolism_Homo sapiens_hsa003601.61701785
36Selenocompound metabolism_Homo sapiens_hsa004501.56741608
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54555385
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52554758
39Tyrosine metabolism_Homo sapiens_hsa003501.48347574
40Bile secretion_Homo sapiens_hsa049761.47463136
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42259749
42Fatty acid elongation_Homo sapiens_hsa000621.39864727
43Pyruvate metabolism_Homo sapiens_hsa006201.31727977
44Sulfur metabolism_Homo sapiens_hsa009201.31663963
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29985182
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.28389932
47Starch and sucrose metabolism_Homo sapiens_hsa005001.27711029
48Steroid biosynthesis_Homo sapiens_hsa001001.26922575
49ABC transporters_Homo sapiens_hsa020101.26375468
50Parkinsons disease_Homo sapiens_hsa050121.24095549
51Folate biosynthesis_Homo sapiens_hsa007901.22503615
52Homologous recombination_Homo sapiens_hsa034401.21138705
53Fat digestion and absorption_Homo sapiens_hsa049751.20128964
54Biosynthesis of amino acids_Homo sapiens_hsa012301.14421636
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.10680057
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09589575
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08325355
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08311016
59RNA polymerase_Homo sapiens_hsa030201.07568629
60Carbon metabolism_Homo sapiens_hsa012001.06587480
61Basal transcription factors_Homo sapiens_hsa030221.04443805
62Huntingtons disease_Homo sapiens_hsa050161.04047173
63Fanconi anemia pathway_Homo sapiens_hsa034601.00607955
64Vitamin B6 metabolism_Homo sapiens_hsa007500.99425190
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.98047413
66Arginine and proline metabolism_Homo sapiens_hsa003300.97351626
67Protein export_Homo sapiens_hsa030600.93416753
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92530123
69Nicotine addiction_Homo sapiens_hsa050330.91455184
70Sulfur relay system_Homo sapiens_hsa041220.91264104
71Vitamin digestion and absorption_Homo sapiens_hsa049770.88086147
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86261701
73Olfactory transduction_Homo sapiens_hsa047400.78456050
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77696366
75Lysine degradation_Homo sapiens_hsa003100.77289326
76Glutathione metabolism_Homo sapiens_hsa004800.69900818
77One carbon pool by folate_Homo sapiens_hsa006700.69651222
78Glycerolipid metabolism_Homo sapiens_hsa005610.69494340
79Alzheimers disease_Homo sapiens_hsa050100.67315724
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66611920
81Collecting duct acid secretion_Homo sapiens_hsa049660.63714057
82Fatty acid biosynthesis_Homo sapiens_hsa000610.58751860
83Taste transduction_Homo sapiens_hsa047420.57920282
84Ribosome_Homo sapiens_hsa030100.57625757
85Serotonergic synapse_Homo sapiens_hsa047260.57240846
86Pyrimidine metabolism_Homo sapiens_hsa002400.54649449
87Pentose phosphate pathway_Homo sapiens_hsa000300.52997196
88Purine metabolism_Homo sapiens_hsa002300.48858180
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48711000
90Morphine addiction_Homo sapiens_hsa050320.47855084
91Metabolic pathways_Homo sapiens_hsa011000.46336486
92Cardiac muscle contraction_Homo sapiens_hsa042600.46128053
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43639332
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43220548
95RNA degradation_Homo sapiens_hsa030180.40234472
96GABAergic synapse_Homo sapiens_hsa047270.38287122
97Prion diseases_Homo sapiens_hsa050200.37755329
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37189720
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31239512
100Proteasome_Homo sapiens_hsa030500.30202979
101Linoleic acid metabolism_Homo sapiens_hsa005910.27726832
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27423539
103Nucleotide excision repair_Homo sapiens_hsa034200.25926019
104Insulin resistance_Homo sapiens_hsa049310.22419402
105Galactose metabolism_Homo sapiens_hsa000520.21851618
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.21529416
107Fructose and mannose metabolism_Homo sapiens_hsa000510.20924868
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.19183054
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16322151
110Glucagon signaling pathway_Homo sapiens_hsa049220.08096059
111AMPK signaling pathway_Homo sapiens_hsa041520.01045750
112Mineral absorption_Homo sapiens_hsa04978-0.2360143
113Bladder cancer_Homo sapiens_hsa05219-0.2281021
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2179520
115Amoebiasis_Homo sapiens_hsa05146-0.2146411
116Pertussis_Homo sapiens_hsa05133-0.2143801
117Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2094855
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1968741
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1813538
120Ether lipid metabolism_Homo sapiens_hsa00565-0.1772441
121Renin-angiotensin system_Homo sapiens_hsa04614-0.1709142
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1535600
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1507288
124African trypanosomiasis_Homo sapiens_hsa05143-0.1453744
125Hepatitis C_Homo sapiens_hsa05160-0.1442074
126Regulation of autophagy_Homo sapiens_hsa04140-0.1341976
127Insulin signaling pathway_Homo sapiens_hsa04910-0.1159239
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1127311
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1122526
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0457101
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0452928
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0265954

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