SDR9C7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been shown to have retinoid or dehydrogenase activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.13312738
2hair cycle (GO:0042633)9.05009472
3molting cycle (GO:0042303)9.05009472
4multicellular organismal water homeostasis (GO:0050891)8.79557443
5epidermal cell differentiation (GO:0009913)8.78215812
6keratinocyte proliferation (GO:0043616)7.92655892
7positive regulation of interleukin-8 secretion (GO:2000484)7.74161198
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55993931
9L-phenylalanine catabolic process (GO:0006559)7.55993931
10regulation of transforming growth factor beta1 production (GO:0032908)7.38191719
11water homeostasis (GO:0030104)7.34582860
12L-phenylalanine metabolic process (GO:0006558)7.19370359
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19370359
14positive regulation of glomerulus development (GO:0090193)7.01682364
15aromatic amino acid family catabolic process (GO:0009074)6.91363621
16epidermis development (GO:0008544)6.90695697
17positive regulation of humoral immune response (GO:0002922)6.73609372
18peptide cross-linking (GO:0018149)6.73592732
19indole-containing compound catabolic process (GO:0042436)6.39202197
20indolalkylamine catabolic process (GO:0046218)6.39202197
21tryptophan catabolic process (GO:0006569)6.39202197
22defense response to Gram-negative bacterium (GO:0050829)6.32097223
23kynurenine metabolic process (GO:0070189)6.25951143
24bile acid biosynthetic process (GO:0006699)6.25028302
25long-chain fatty acid biosynthetic process (GO:0042759)6.15894502
26positive regulation of p38MAPK cascade (GO:1900745)6.03984087
27regulation of cell proliferation involved in kidney development (GO:1901722)6.01471377
28tryptophan metabolic process (GO:0006568)5.99633596
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92632148
30defense response to fungus (GO:0050832)5.87324607
31glyoxylate metabolic process (GO:0046487)5.84847195
32complement activation, alternative pathway (GO:0006957)5.76859024
33phosphatidylserine acyl-chain remodeling (GO:0036150)5.68620560
34positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.64615648
35regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.64615648
36regulation of protein activation cascade (GO:2000257)5.63632590
37urea cycle (GO:0000050)5.60830029
38urea metabolic process (GO:0019627)5.60830029
39phosphatidylinositol acyl-chain remodeling (GO:0036149)5.58906067
40alpha-linolenic acid metabolic process (GO:0036109)5.54190459
41cysteine metabolic process (GO:0006534)5.48429489
42regulation of cellular amide metabolic process (GO:0034248)5.47588424
43negative regulation of fibrinolysis (GO:0051918)5.45682298
44protein carboxylation (GO:0018214)5.37294109
45peptidyl-glutamic acid carboxylation (GO:0017187)5.37294109
46regulation of fibrinolysis (GO:0051917)5.34746221
47regulation of complement activation (GO:0030449)5.33500823
48sulfur amino acid catabolic process (GO:0000098)5.32532672
49lipoxygenase pathway (GO:0019372)5.31569441
50antimicrobial humoral response (GO:0019730)5.31363078
51high-density lipoprotein particle remodeling (GO:0034375)5.27470510
52bile acid metabolic process (GO:0008206)5.19846094
53nitrogen cycle metabolic process (GO:0071941)5.16374470
54regulation of interleukin-8 secretion (GO:2000482)5.15481279
55detection of bacterium (GO:0016045)5.13695062
56skin morphogenesis (GO:0043589)5.12116989
57positive regulation of T-helper 1 type immune response (GO:0002827)5.10139617
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.07840320
59serine family amino acid catabolic process (GO:0009071)5.04411170
60aromatic amino acid family metabolic process (GO:0009072)5.00576261
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.98783412
62intermediate filament organization (GO:0045109)4.92587256
63linoleic acid metabolic process (GO:0043651)4.88622458
64negative regulation of interleukin-17 production (GO:0032700)4.87162273
65homocysteine metabolic process (GO:0050667)4.82809512
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.81715116
67bundle of His cell to Purkinje myocyte communication (GO:0086069)4.77069333
68intermediate filament cytoskeleton organization (GO:0045104)4.75590284
69regulation of triglyceride catabolic process (GO:0010896)4.73293911
70tyrosine metabolic process (GO:0006570)4.68407385
71coenzyme catabolic process (GO:0009109)4.66797648
72ectoderm development (GO:0007398)4.65990127
73alpha-amino acid catabolic process (GO:1901606)4.64581484
74detection of other organism (GO:0098543)4.64454837
75lysine catabolic process (GO:0006554)4.62131792
76lysine metabolic process (GO:0006553)4.62131792
77intermediate filament-based process (GO:0045103)4.60389849
78fatty acid elongation (GO:0030497)4.60368837
79reverse cholesterol transport (GO:0043691)4.58101854
80triglyceride homeostasis (GO:0070328)4.57483018
81acylglycerol homeostasis (GO:0055090)4.57483018
82phospholipid efflux (GO:0033700)4.55743279
83regulation of glomerulus development (GO:0090192)4.51940425
84indolalkylamine metabolic process (GO:0006586)4.51771988
85protein-lipid complex remodeling (GO:0034368)4.50832103
86macromolecular complex remodeling (GO:0034367)4.50832103
87plasma lipoprotein particle remodeling (GO:0034369)4.50832103
88bile acid and bile salt transport (GO:0015721)4.50660700
89amino-acid betaine metabolic process (GO:0006577)4.49446055
90glycine metabolic process (GO:0006544)4.49049551
91imidazole-containing compound metabolic process (GO:0052803)4.48170226
92regulation of cholesterol esterification (GO:0010872)4.44157426
93phosphatidylcholine acyl-chain remodeling (GO:0036151)4.42750185
94regulation of p38MAPK cascade (GO:1900744)4.42703481
95cellular biogenic amine catabolic process (GO:0042402)4.42611714
96amine catabolic process (GO:0009310)4.42611714
97negative regulation of interferon-gamma production (GO:0032689)4.39413279
98surfactant homeostasis (GO:0043129)4.32591246
99negative regulation of sterol transport (GO:0032372)4.30404587
100negative regulation of cholesterol transport (GO:0032375)4.30404587
101cellular ketone body metabolic process (GO:0046950)4.30356831
102glutamate metabolic process (GO:0006536)4.28563414
103cellular amino acid catabolic process (GO:0009063)4.28496230
104cytolysis (GO:0019835)4.27581018
105cellular glucuronidation (GO:0052695)4.26242639
106serine family amino acid metabolic process (GO:0009069)4.24612658
107ethanol oxidation (GO:0006069)4.23136386
108cellular modified amino acid catabolic process (GO:0042219)4.16330234
109plasma lipoprotein particle clearance (GO:0034381)4.16081502
110benzene-containing compound metabolic process (GO:0042537)4.10699995
111chemical homeostasis within a tissue (GO:0048875)4.09382886
112fibrinolysis (GO:0042730)4.09094213
113serine family amino acid biosynthetic process (GO:0009070)4.08360319
114positive regulation of transforming growth factor beta production (GO:0071636)4.06929284
115activation of MAPKKK activity (GO:0000185)4.05426233
116complement activation, classical pathway (GO:0006958)4.03739686
117dicarboxylic acid biosynthetic process (GO:0043650)4.02939703
118cholesterol efflux (GO:0033344)4.02368451
119response to fungus (GO:0009620)4.02028058
120positive regulation of epidermis development (GO:0045684)4.00260458
121positive regulation of cholesterol efflux (GO:0010875)3.99192625
122complement activation (GO:0006956)3.97395922
123regulation of natural killer cell differentiation (GO:0032823)3.93598611
124aldehyde catabolic process (GO:0046185)3.89220908
125arginine metabolic process (GO:0006525)3.86510995
126protein activation cascade (GO:0072376)3.84676704
127cofactor catabolic process (GO:0051187)3.81655015
128acetyl-CoA metabolic process (GO:0006084)3.79965651
129uronic acid metabolic process (GO:0006063)3.77954122
130glucuronate metabolic process (GO:0019585)3.77954122
131blood coagulation, intrinsic pathway (GO:0007597)3.77880345
132antibacterial humoral response (GO:0019731)3.77441543
133low-density lipoprotein particle remodeling (GO:0034374)3.77412317
134ceramide biosynthetic process (GO:0046513)3.75484134
135regulation of cholesterol homeostasis (GO:2000188)3.75000203
136plasma lipoprotein particle assembly (GO:0034377)3.74931214
137organic acid catabolic process (GO:0016054)3.73528259
138carboxylic acid catabolic process (GO:0046395)3.73528259
139ketone body metabolic process (GO:1902224)3.72385351
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.72348533
141regulation of MHC class I biosynthetic process (GO:0045343)3.71476137
142natural killer cell activation involved in immune response (GO:0002323)3.71466518
143positive regulation of triglyceride lipase activity (GO:0061365)3.68029284
144positive regulation of lipoprotein lipase activity (GO:0051006)3.68029284
145keratinocyte development (GO:0003334)3.68022048
146regulation of T-helper 1 type immune response (GO:0002825)3.67716034
147very-low-density lipoprotein particle assembly (GO:0034379)3.66271953
148positive regulation of response to biotic stimulus (GO:0002833)3.65980175
149regulation of bile acid biosynthetic process (GO:0070857)3.63764435
150cholesterol homeostasis (GO:0042632)3.63569601
151phospholipid homeostasis (GO:0055091)3.62802488
152dendritic cell migration (GO:0036336)3.57787704
153sterol homeostasis (GO:0055092)3.57355008
154intestinal cholesterol absorption (GO:0030299)3.57229215
155negative regulation of lipase activity (GO:0060192)3.56298770
156positive regulation of lipid catabolic process (GO:0050996)3.56032927
157positive regulation of sterol transport (GO:0032373)3.55498906
158positive regulation of cholesterol transport (GO:0032376)3.55498906
159short-chain fatty acid metabolic process (GO:0046459)3.52989586
160positive regulation of keratinocyte differentiation (GO:0045618)3.52453907
161NAD biosynthetic process (GO:0009435)3.51655664
162nicotinamide nucleotide biosynthetic process (GO:0019359)3.49755794
163pyridine nucleotide biosynthetic process (GO:0019363)3.49755794
164aspartate family amino acid catabolic process (GO:0009068)3.47321342
165regulation of neuron projection regeneration (GO:0070570)3.43960912
166regulation of axon regeneration (GO:0048679)3.43960912
167positive regulation of epidermal cell differentiation (GO:0045606)3.41380663
168phosphatidylserine metabolic process (GO:0006658)3.38258174
169positive regulation of meiotic cell cycle (GO:0051446)3.29996550
170epithelium development (GO:0060429)3.14790940
171branching involved in labyrinthine layer morphogenesis (GO:0060670)3.13565183
172regulation of hair cycle (GO:0042634)3.11190365
173establishment of planar polarity (GO:0001736)3.09818358
174establishment of tissue polarity (GO:0007164)3.09818358
175hemidesmosome assembly (GO:0031581)3.05546624
176gap junction assembly (GO:0016264)3.01317854
177keratinization (GO:0031424)27.4638434
178cellular response to arsenic-containing substance (GO:0071243)2.97133893
179negative regulation of meiotic cell cycle (GO:0051447)2.95308171
180regulation of epidermis development (GO:0045682)2.94542312
181hair cell differentiation (GO:0035315)2.92236621
182positive regulation of interleukin-6 production (GO:0032755)2.88788416
183regulation of keratinocyte differentiation (GO:0045616)2.85451095
184regulation of transforming growth factor beta production (GO:0071634)2.76460026
185defense response to Gram-positive bacterium (GO:0050830)2.75489654
186phospholipid catabolic process (GO:0009395)2.72030429
187regulation of collagen biosynthetic process (GO:0032965)2.70969375
188alditol phosphate metabolic process (GO:0052646)2.68351317
189regulation of ruffle assembly (GO:1900027)2.68039779
190positive regulation of collagen biosynthetic process (GO:0032967)2.62781000
191early endosome to late endosome transport (GO:0045022)2.59926894
192regulation of interleukin-17 production (GO:0032660)2.54098930
193regulation of interleukin-6 production (GO:0032675)2.51760793
194regulation of cholesterol efflux (GO:0010874)2.50981807
195establishment of skin barrier (GO:0061436)16.2449685
196regulation of water loss via skin (GO:0033561)13.9973228
197positive regulation of cellular amide metabolic process (GO:0034250)10.6594156
198keratinocyte differentiation (GO:0030216)10.2741030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.14598207
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07191261
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01224113
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.98285747
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.34307830
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24960341
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85782217
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56720967
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99543110
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.75678930
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.34253328
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.18655428
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.18655428
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.62032796
15SOX9_24532713_ChIP-Seq_HFSC_Mouse2.25697509
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7006859
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97290660
18RXR_22108803_ChIP-Seq_LS180_Human1.92467827
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90169479
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88206606
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82122686
22HTT_18923047_ChIP-ChIP_STHdh_Human1.67575930
23* TP63_22573176_ChIP-Seq_HFKS_Human1.66244491
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65237076
25ATF3_27146783_Chip-Seq_COLON_Human1.64172525
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.59791764
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.58378863
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.53170780
29CLOCK_20551151_ChIP-Seq_293T_Human1.47606481
30JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41860622
31CTCF_27219007_Chip-Seq_Bcells_Human1.40634967
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40513918
33HNF4A_19822575_ChIP-Seq_HepG2_Human1.34389139
34TP53_18474530_ChIP-ChIP_U2OS_Human1.32227630
35* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30552277
36GATA1_22025678_ChIP-Seq_K562_Human1.28735217
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27979140
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27345045
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27100228
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24534032
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23871175
42RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20197013
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19867589
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.18844945
45CTCF_20526341_ChIP-Seq_ESCs_Human1.17223823
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.17037411
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14854042
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14490458
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13734152
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.13145386
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11919379
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09059754
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07189836
54KLF5_25053715_ChIP-Seq_YYC3_Human1.06830360
55TP53_16413492_ChIP-PET_HCT116_Human1.05261673
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02490146
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02307606
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01086800
59CJUN_26792858_Chip-Seq_BT549_Human0.99790517
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97274805
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96754990
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94991036
63GATA4_25053715_ChIP-Seq_YYC3_Human0.91784325
64* RACK7_27058665_Chip-Seq_MCF-7_Human0.91742173
65YY1_22570637_ChIP-Seq_MALME-3M_Human0.91592833
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90416295
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90329492
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90196634
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89452851
70ESR2_21235772_ChIP-Seq_MCF-7_Human0.87579503
71CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87036272
72RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85910681
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84563963
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84275362
75SMC4_20622854_ChIP-Seq_HELA_Human0.84109851
76ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83602691
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83307457
78IRF8_22096565_ChIP-ChIP_GC-B_Human0.80354735
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79126830
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78454672
81ESR1_21235772_ChIP-Seq_MCF-7_Human0.77077226
82ZNF263_19887448_ChIP-Seq_K562_Human0.76904023
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75975822
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75281607
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75163922
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73933748
87RBPJ_21746931_ChIP-Seq_IB4_Human0.72696616
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72557059
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.72463200
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72102945
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72102945
92BCOR_27268052_Chip-Seq_Bcells_Human0.70787752
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69481739
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69309459
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69076139
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.68890227
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.67824413
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67536152
99SMAD4_21741376_ChIP-Seq_ESCs_Human0.66643226
100* CEBPB_22108803_ChIP-Seq_LS180_Human0.66627636
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66311450
102* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66214406
103EGR1_19032775_ChIP-ChIP_M12_Human0.65903344
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.65803226
105GATA3_21867929_ChIP-Seq_TH1_Mouse0.64756480
106* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.64727215
107TAF15_26573619_Chip-Seq_HEK293_Human0.64705922
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64474979
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.64307598
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64140254
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63846349
112RARB_24833708_ChIP-Seq_LIVER_Mouse0.63211411
113* E2F1_20622854_ChIP-Seq_HELA_Human0.63043074
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62659733
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.61828721
116FOXH1_21741376_ChIP-Seq_ESCs_Human0.61813296
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.61573175
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.61421610
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60950803
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.60173715
121NCOR_22424771_ChIP-Seq_293T_Human0.58333880
122AR_20517297_ChIP-Seq_VCAP_Human0.56416427
123MYC_19915707_ChIP-ChIP_AK7_Human0.55873085
124LXR_22292898_ChIP-Seq_THP-1_Human0.54487700
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54227427
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53859321
127TAF2_19829295_ChIP-Seq_ESCs_Human0.53372366
128* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52231678
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.52006281
130CBP_21632823_ChIP-Seq_H3396_Human0.51646362
131* P53_21459846_ChIP-Seq_SAOS-2_Human0.50780032
132* ESET_19884257_ChIP-Seq_ESCs_Mouse0.50637277
133BCAT_22108803_ChIP-Seq_LS180_Human0.50176926
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49907820
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47945510
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47911222
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.47908704
138STAT1_17558387_ChIP-Seq_HELA_Human0.47708157
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.47476169
140GATA6_25053715_ChIP-Seq_YYC3_Human0.47404890
141ERG_20517297_ChIP-Seq_VCAP_Human0.46126980
142* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.45608985
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45186553
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44264801
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44126529
146SOX2_20726797_ChIP-Seq_SW620_Human0.43391322
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42717979
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42242719
149* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42222876
150* GATA3_24758297_ChIP-Seq_MCF-7_Human0.41968329
151* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40398283
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.39764975
153GATA2_19941826_ChIP-Seq_K562_Human0.38894754
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.38892915
155STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37360054
156GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.37071487
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.36845823
158* TP63_23658742_ChIP-Seq_EP156T_Human0.36509578
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36489185
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.36327453
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36123840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.13114557
2MP0005360_urolithiasis7.36398976
3MP0005085_abnormal_gallbladder_physiolo6.46600821
4MP0005365_abnormal_bile_salt6.22370852
5MP0008875_abnormal_xenobiotic_pharmacok4.64692143
6MP0003941_abnormal_skin_development4.43908342
7MP0003806_abnormal_nucleotide_metabolis4.32242752
8MP0003252_abnormal_bile_duct3.92158671
9MP0010329_abnormal_lipoprotein_level3.45568179
10MP0010678_abnormal_skin_adnexa3.43322846
11MP0005083_abnormal_biliary_tract3.20651643
12MP0009840_abnormal_foam_cell2.93526696
13MP0001666_abnormal_nutrient_absorption2.87607389
14MP0003195_calcinosis2.68185437
15MP0000383_abnormal_hair_follicle2.63455590
16MP0002098_abnormal_vibrissa_morphology2.63190326
17MP0005332_abnormal_amino_acid2.60385595
18MP0003191_abnormal_cellular_cholesterol2.40420398
19MP0000609_abnormal_liver_physiology2.09625815
20MP0002118_abnormal_lipid_homeostasis2.07856601
21MP0003868_abnormal_feces_composition2.03732220
22MP0004019_abnormal_vitamin_homeostasis1.97611107
23MP0002138_abnormal_hepatobiliary_system1.84687884
24MP0003950_abnormal_plasma_membrane1.81954826
25MP0005451_abnormal_body_composition1.80252366
26MP0005319_abnormal_enzyme/_coenzyme1.75241328
27MP0002796_impaired_skin_barrier1.54421944
28MP0001764_abnormal_homeostasis1.53919625
29MP0001188_hyperpigmentation1.53411227
30MP0009697_abnormal_copulation1.45475931
31MP0005584_abnormal_enzyme/coenzyme_acti1.45338323
32MP0000566_synostosis1.44256207
33MP0005377_hearing/vestibular/ear_phenot1.43505587
34MP0003878_abnormal_ear_physiology1.43505587
35MP0000367_abnormal_coat/_hair1.43016857
36MP0003705_abnormal_hypodermis_morpholog1.42723688
37MP0004885_abnormal_endolymph1.38445497
38MP0000762_abnormal_tongue_morphology1.38402926
39MP0003011_delayed_dark_adaptation1.35932110
40MP0002254_reproductive_system_inflammat1.29182907
41MP0005647_abnormal_sex_gland1.22257785
42MP0001191_abnormal_skin_condition1.17506419
43MP0004381_abnormal_hair_follicle1.15526594
44MP0003186_abnormal_redox_activity1.15356284
45MP0009643_abnormal_urine_homeostasis1.12344732
46MP0005409_darkened_coat_color1.11825607
47MP0003656_abnormal_erythrocyte_physiolo1.11311316
48MP0000598_abnormal_liver_morphology1.09411209
49MP0004264_abnormal_extraembryonic_tissu1.03052571
50MP0000579_abnormal_nail_morphology1.02051892
51MP0002095_abnormal_skin_pigmentation0.99351617
52MP0000604_amyloidosis0.98468494
53MP0009764_decreased_sensitivity_to0.97920964
54MP0010368_abnormal_lymphatic_system0.94786041
55MP0009763_increased_sensitivity_to0.94217789
56MP0005220_abnormal_exocrine_pancreas0.90747046
57MP0004185_abnormal_adipocyte_glucose0.89780245
58MP0003566_abnormal_cell_adhesion0.85813349
59MP0005636_abnormal_mineral_homeostasis0.85552433
60MP0008004_abnormal_stomach_pH0.84484969
61MP0010234_abnormal_vibrissa_follicle0.84408337
62MP0001784_abnormal_fluid_regulation0.84021883
63MP0008469_abnormal_protein_level0.83939743
64MP0005084_abnormal_gallbladder_morpholo0.81306851
65MP0005408_hypopigmentation0.81188443
66MP0009642_abnormal_blood_homeostasis0.79969132
67MP0002876_abnormal_thyroid_physiology0.77291346
68MP0000465_gastrointestinal_hemorrhage0.76363814
69MP0010352_gastrointestinal_tract_polyps0.75320717
70MP0005501_abnormal_skin_physiology0.73461024
71MP0009765_abnormal_xenobiotic_induced0.73107348
72MP0006036_abnormal_mitochondrial_physio0.72783296
73MP0002078_abnormal_glucose_homeostasis0.72157377
74MP0005376_homeostasis/metabolism_phenot0.70609693
75MP0002971_abnormal_brown_adipose0.70389360
76MP0005670_abnormal_white_adipose0.68991743
77MP0005535_abnormal_body_temperature0.67866491
78MP0004130_abnormal_muscle_cell0.66978690
79MP0005334_abnormal_fat_pad0.66613295
80MP0004272_abnormal_basement_membrane0.65111815
81MP0002060_abnormal_skin_morphology0.64520245
82MP0001851_eye_inflammation0.64304147
83MP0003329_amyloid_beta_deposits0.62579495
84MP0004043_abnormal_pH_regulation0.61635264
85MP0009053_abnormal_anal_canal0.61090076
86MP0003690_abnormal_glial_cell0.59633561
87MP0001661_extended_life_span0.59540323
88MP0003221_abnormal_cardiomyocyte_apopto0.59431866
89MP0005266_abnormal_metabolism0.58588976
90MP0004782_abnormal_surfactant_physiolog0.58226194
91MP0004947_skin_inflammation0.57262440
92MP0005448_abnormal_energy_balance0.56051304
93MP0005275_abnormal_skin_tensile0.55718836
94MP0005023_abnormal_wound_healing0.55134362
95MP0000427_abnormal_hair_cycle0.54989644
96MP0001177_atelectasis0.53970316
97MP0000015_abnormal_ear_pigmentation0.53505219
98MP0006035_abnormal_mitochondrial_morpho0.53129790
99MP0000639_abnormal_adrenal_gland0.51926559
100MP0009384_cardiac_valve_regurgitation0.51729015
101MP0002234_abnormal_pharynx_morphology0.50775528
102MP0003453_abnormal_keratinocyte_physiol0.50352230
103MP0005174_abnormal_tail_pigmentation0.49366917
104MP0000647_abnormal_sebaceous_gland0.47305252
105MP0001216_abnormal_epidermal_layer0.47017282
106MP0001756_abnormal_urination0.45902512
107MP0003638_abnormal_response/metabolism_0.45380106
108MP0001340_abnormal_eyelid_morphology0.44967923
109MP0001243_abnormal_dermal_layer0.42974340
110MP0002928_abnormal_bile_duct0.42427212
111MP0002822_catalepsy0.41949869
112MP0005666_abnormal_adipose_tissue0.41896155
113MP0003724_increased_susceptibility_to0.41286927
114MP0002177_abnormal_outer_ear0.40951772
115MP0000377_abnormal_hair_follicle0.40762442
116MP0005395_other_phenotype0.40299295
117MP0005166_decreased_susceptibility_to0.40058838
118MP0009379_abnormal_foot_pigmentation0.39447037
119MP0003718_maternal_effect0.39350453
120MP0003828_pulmonary_edema0.38701716
121MP0008873_increased_physiological_sensi0.38362917
122MP0003075_altered_response_to0.38163893
123MP0005075_abnormal_melanosome_morpholog0.38096488
124MP0005464_abnormal_platelet_physiology0.37535188
125MP0005248_abnormal_Harderian_gland0.36659015
126MP0008874_decreased_physiological_sensi0.36583688
127MP0004510_myositis0.36475998
128MP0002136_abnormal_kidney_physiology0.36306716
129MP0009672_abnormal_birth_weight0.36019586
130MP0003953_abnormal_hormone_level0.35727059
131MP0009931_abnormal_skin_appearance0.35159665
132MP0003436_decreased_susceptibility_to0.35141828
133MP0002837_dystrophic_cardiac_calcinosis0.34967299
134MP0008057_abnormal_DNA_replication0.34533265
135MP0000467_abnormal_esophagus_morphology0.34006260
136MP0010771_integument_phenotype0.33949574
137MP0002009_preneoplasia0.33550888
138MP0003755_abnormal_palate_morphology0.32757399
139MP0005375_adipose_tissue_phenotype0.30694054
140MP0002133_abnormal_respiratory_system0.30196233
141MP0005388_respiratory_system_phenotype0.30196233
142MP0009333_abnormal_splenocyte_physiolog0.28221124
143MP0003315_abnormal_perineum_morphology0.27442091
144MP0004197_abnormal_fetal_growth/weight/0.26813912
145MP0008995_early_reproductive_senescence0.25519805
146MP0002111_abnormal_tail_morphology0.24739355
147MP0010030_abnormal_orbit_morphology0.22823939
148MP0002697_abnormal_eye_size0.22472958
149MP0001502_abnormal_circadian_rhythm0.21976778
150MP0000627_abnormal_mammary_gland0.21506568
151MP0005171_absent_coat_pigmentation0.19991933
152MP0001984_abnormal_olfaction0.19721639
153MP0002295_abnormal_pulmonary_circulatio0.16617526
154MP0002877_abnormal_melanocyte_morpholog0.15858367
155MP0000470_abnormal_stomach_morphology0.13475977
156MP0005076_abnormal_cell_differentiation0.12442307
157MP0005503_abnormal_tendon_morphology0.12147187
158MP0001186_pigmentation_phenotype0.11761400
159MP0006072_abnormal_retinal_apoptosis0.10986921
160MP0008789_abnormal_olfactory_epithelium0.10981339
161MP0000003_abnormal_adipose_tissue0.10810890
162MP0003763_abnormal_thymus_physiology0.10111133
163MP0005193_abnormal_anterior_eye0.09450198
164MP0000432_abnormal_head_morphology0.08352975
165MP0005508_abnormal_skeleton_morphology0.07683891

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.77893856
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.29798296
3Congenital ichthyosiform erythroderma (HP:0007431)9.04145778
4Palmoplantar hyperkeratosis (HP:0000972)8.69736302
5Parakeratosis (HP:0001036)8.53880554
6Palmar hyperkeratosis (HP:0010765)8.27380634
7Erythroderma (HP:0001019)8.08286095
8Intrahepatic cholestasis (HP:0001406)7.73708700
9Deep venous thrombosis (HP:0002625)7.33930665
10Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23061365
11Oral leukoplakia (HP:0002745)7.17561307
12Plantar hyperkeratosis (HP:0007556)7.02125308
13Erythema (HP:0010783)6.68722802
14Prolonged partial thromboplastin time (HP:0003645)6.57500567
15Abnormality of monocarboxylic acid metabolism (HP:0010996)6.53981214
16Thick nail (HP:0001805)6.27327018
17Hypobetalipoproteinemia (HP:0003563)6.25094905
18Xanthomatosis (HP:0000991)6.24374318
19Complement deficiency (HP:0004431)6.10193436
20Hypotrichosis (HP:0001006)5.41844766
21Onycholysis (HP:0001806)5.41523198
22Hyperlipoproteinemia (HP:0010980)5.35977838
23Corneal erosion (HP:0200020)5.30113349
24Ectropion (HP:0000656)4.68002309
25Epidermoid cyst (HP:0200040)4.67225392
26Palmoplantar keratoderma (HP:0000982)4.66963193
27Joint hemorrhage (HP:0005261)4.64351419
28Hypolipoproteinemia (HP:0010981)4.63750721
29Fat malabsorption (HP:0002630)4.53551271
30Hyperglycinemia (HP:0002154)4.51909638
31Follicular hyperkeratosis (HP:0007502)4.51444448
32Abnormality of complement system (HP:0005339)4.49026620
33Abnormality of the common coagulation pathway (HP:0010990)4.47965602
34Gangrene (HP:0100758)4.47130221
35Hypohidrosis (HP:0000966)4.47061556
36Hyperammonemia (HP:0001987)4.46989256
37Alopecia of scalp (HP:0002293)4.41263492
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24087226
39Abnormality of sulfur amino acid metabolism (HP:0004339)4.15654304
40Ketosis (HP:0001946)4.14669985
41Abnormality of methionine metabolism (HP:0010901)4.06849007
42Fragile nails (HP:0001808)4.01384509
43Abnormality of the axillary hair (HP:0100134)4.01051444
44Abnormality of secondary sexual hair (HP:0009888)4.01051444
45Hypoalphalipoproteinemia (HP:0003233)4.00039594
46Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95079497
47Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92061519
48Abnormality of the intrinsic pathway (HP:0010989)3.89854092
49Nail dystrophy (HP:0008404)3.88583551
50Conjugated hyperbilirubinemia (HP:0002908)3.88499370
51Abnormality of glycine metabolism (HP:0010895)3.87589141
52Abnormality of serine family amino acid metabolism (HP:0010894)3.87589141
53Hyperglycinuria (HP:0003108)3.83050724
54Hypoglycemic coma (HP:0001325)3.78068316
55Lip pit (HP:0100267)3.71813882
56Abnormality of pyrimidine metabolism (HP:0004353)3.59815599
57Pustule (HP:0200039)3.57467553
58Steatorrhea (HP:0002570)3.55962066
59Hypercholesterolemia (HP:0003124)3.41621788
60Pruritus (HP:0000989)3.38949400
61Conjunctival hamartoma (HP:0100780)3.32721497
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29127807
63Woolly hair (HP:0002224)3.27070517
64Abnormality of fatty-acid metabolism (HP:0004359)3.24337366
65Hyperbilirubinemia (HP:0002904)3.21442359
66Right ventricular cardiomyopathy (HP:0011663)3.19721501
67Sparse scalp hair (HP:0002209)3.14587482
68Abnormal blistering of the skin (HP:0008066)3.12285547
69Hypochromic microcytic anemia (HP:0004840)3.08198690
70Myocardial infarction (HP:0001658)3.05339331
71Delayed CNS myelination (HP:0002188)3.02954558
72Abnormality of serum amino acid levels (HP:0003112)3.00730011
73Systemic lupus erythematosus (HP:0002725)2.98983066
74Ketoacidosis (HP:0001993)2.94244907
75Abnormality of nucleobase metabolism (HP:0010932)2.93645823
76Hyperhidrosis (HP:0000975)2.93296644
77Abnormality of the salivary glands (HP:0010286)2.92067728
78Hepatocellular carcinoma (HP:0001402)2.91976695
79Spontaneous abortion (HP:0005268)2.88852214
80Laryngomalacia (HP:0001601)2.85177213
81Skin nodule (HP:0200036)2.83741318
82Lack of skin elasticity (HP:0100679)2.81374539
83Recurrent gram-negative bacterial infections (HP:0005420)2.74590658
84Furrowed tongue (HP:0000221)2.71227456
85Metabolic acidosis (HP:0001942)2.65416253
86Abnormality of purine metabolism (HP:0004352)2.60560935
87Sparse eyelashes (HP:0000653)2.57410723
88Absent eyelashes (HP:0000561)2.56199756
89Dehydration (HP:0001944)2.55721608
90Vascular calcification (HP:0004934)2.54799099
91Neonatal onset (HP:0003623)2.52021961
92Natal tooth (HP:0000695)2.50737857
93Hypergammaglobulinemia (HP:0010702)2.50214646
94Lethargy (HP:0001254)2.49301450
95Abnormal gallbladder morphology (HP:0012437)2.48980203
96Gout (HP:0001997)2.48743622
97Acanthocytosis (HP:0001927)2.48027408
98Corneal dystrophy (HP:0001131)2.47034253
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46345687
100Dicarboxylic aciduria (HP:0003215)2.46345687
101Spastic diplegia (HP:0001264)2.44165393
102Cholelithiasis (HP:0001081)2.43972337
103Hypoglycemic seizures (HP:0002173)2.43150584
104Brittle hair (HP:0002299)2.40210583
105Mitral stenosis (HP:0001718)2.36544443
106Malnutrition (HP:0004395)2.32627217
107Abnormal gallbladder physiology (HP:0012438)2.31894680
108Cholecystitis (HP:0001082)2.31894680
109Cerebral edema (HP:0002181)2.31828984
110Eczematoid dermatitis (HP:0000976)2.31406476
111Absent hair (HP:0002298)2.30074530
112Cardiovascular calcification (HP:0011915)2.26115289
113Sensorimotor neuropathy (HP:0007141)2.23438918
114Irritability (HP:0000737)2.22800453
115Amyloidosis (HP:0011034)2.21924915
116Glomerulonephritis (HP:0000099)2.21690962
117Pancreatitis (HP:0001733)2.19055386
118Hamartoma of the eye (HP:0010568)2.16417532
119Brushfield spots (HP:0001088)2.11174252
120Abnormality of small intestinal villus morphology (HP:0011472)2.10723141
121Villous atrophy (HP:0011473)2.10723141
122Late onset (HP:0003584)2.10513103
123Esophageal varix (HP:0002040)2.10164195
124Gingival bleeding (HP:0000225)2.09859540
125Opisthotonus (HP:0002179)2.06007500
126Pili torti (HP:0003777)2.05813017
127Abnormality of the gallbladder (HP:0005264)2.05131758
128Menorrhagia (HP:0000132)2.04375198
129Enlarged kidneys (HP:0000105)2.02919684
130Anonychia (HP:0001798)2.01472992
131Abnormality of nail color (HP:0100643)14.0375857
132Hemorrhage of the eye (HP:0011885)1.99722653
133Hyperinsulinemic hypoglycemia (HP:0000825)1.98996445
134Vomiting (HP:0002013)1.98852490
135Advanced eruption of teeth (HP:0006288)1.98488266
136Thrombophlebitis (HP:0004418)1.97053456
137Rickets (HP:0002748)1.96260123
138Blepharitis (HP:0000498)1.93774472
139Generalized aminoaciduria (HP:0002909)1.91760864
140Abnormal hair laboratory examination (HP:0003328)1.91100742
141Dry skin (HP:0000958)1.90566014
142Dry hair (HP:0011359)1.88760553
143Sepsis (HP:0100806)1.88477778
144Renal cortical cysts (HP:0000803)1.87445572
145Acanthosis nigricans (HP:0000956)1.87116176
146Urticaria (HP:0001025)1.86730164
147Hypophosphatemic rickets (HP:0004912)1.86073562
148Abnormal cartilage morphology (HP:0002763)1.84848013
149Poikilocytosis (HP:0004447)1.84492245
150Milia (HP:0001056)1.84260684
151Abnormal enzyme/coenzyme activity (HP:0012379)1.84033751
152Abnormality of iron homeostasis (HP:0011031)1.79504698
153Verrucae (HP:0200043)1.79070954
154Papilloma (HP:0012740)1.79070954
155Abnormality of transition element cation homeostasis (HP:0011030)1.78506592
156Elevated hepatic transaminases (HP:0002910)1.78214163
157Amniotic constriction ring (HP:0009775)1.74718521
158Abnormality of placental membranes (HP:0011409)1.74718521
159Carious teeth (HP:0000670)1.73967898
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73781623
161Abnormality of vitamin metabolism (HP:0100508)1.73147968
162Hyperglycemia (HP:0003074)1.73120302
163Skin ulcer (HP:0200042)1.72982912
164Hypoplastic labia majora (HP:0000059)1.72181164
165Status epilepticus (HP:0002133)1.71708924
166Distal lower limb muscle weakness (HP:0009053)1.71118134
167Hydroxyprolinuria (HP:0003080)1.71091599
168Abnormality of proline metabolism (HP:0010907)1.71091599
169Abnormality of the Achilles tendon (HP:0005109)1.68503774
170Elevated alkaline phosphatase (HP:0003155)1.66615667
171Ridged nail (HP:0001807)1.63439018
172Curly hair (HP:0002212)1.57242049
173Abnormality of the labia majora (HP:0012881)1.56461315
174Autoamputation (HP:0001218)1.55679081
175Hyporeflexia of lower limbs (HP:0002600)1.55080488
176Melanocytic nevus (HP:0000995)1.54804641
177Abnormality of the fingernails (HP:0001231)1.53109483
178Slow-growing hair (HP:0002217)1.49112060
179Abnormality of hair growth rate (HP:0011363)1.49112060
180Paralysis (HP:0003470)1.45421903
181Popliteal pterygium (HP:0009756)1.44831984
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44579068
183Multifactorial inheritance (HP:0001426)1.44372540
184Selective tooth agenesis (HP:0001592)1.43466721
185Fine hair (HP:0002213)1.42054607
186Duplicated collecting system (HP:0000081)1.35030880
187Premature ovarian failure (HP:0008209)1.33521127
188Malignant hyperthermia (HP:0002047)1.32938840
189Everted lower lip vermilion (HP:0000232)1.32933491
190Conical tooth (HP:0000698)1.27715837
191Asthma (HP:0002099)1.27231287
192Hamartoma (HP:0010566)1.23079847
193Recurrent corneal erosions (HP:0000495)1.18697214
194Abnormality of the renal collecting system (HP:0004742)1.13112144
195Oligodontia (HP:0000677)1.10093311
196Nasolacrimal duct obstruction (HP:0000579)1.06674094
197Split foot (HP:0001839)1.05864357
198Xerostomia (HP:0000217)1.05546030
199Tetraparesis (HP:0002273)1.05429959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.00994070
2ERN14.81783175
3STK244.57120946
4FGFR44.47013900
5SIK14.27471841
6ERBB43.36883630
7TAOK33.28555682
8MAP3K92.86865991
9INSRR2.85965937
10MAP2K42.38455232
11MST1R2.37703381
12PIK3CG2.13973440
13DYRK32.09842176
14LATS12.00540256
15EPHA212.2614367
16MAPK111.95689519
17TGFBR11.89906876
18PKN21.78815912
19TRIB31.68034446
20TYK21.65466174
21IRAK41.57668593
22FLT31.54109352
23FGFR21.49812375
24PTK61.49455813
25MAP3K121.46709162
26MAP3K71.43326672
27FRK1.43146529
28PIM21.39350590
29ABL21.36710142
30NEK91.35216961
31DAPK21.32269411
32WNK11.25367216
33AKT31.23461906
34JAK21.21261785
35ERBB21.11521869
36MOS1.09690422
37MAPK151.08376747
38MAP3K141.08300980
39GRK71.08272497
40PRKAA21.05221795
41STK31.04204625
42PINK11.02715489
43ADRBK11.00504500
44KDR0.99608853
45JAK10.99026974
46TBK10.98274503
47PDGFRB0.94500981
48MET0.94068395
49MAP2K30.93928998
50MAP3K100.93654083
51IKBKB0.93008044
52EPHB10.91674118
53MAPK40.91278130
54PRKCZ0.88495809
55STK38L0.86171383
56MAP3K30.86101892
57EPHA30.83603610
58CDK60.83548572
59IRAK30.83432187
60TAOK10.81235841
61MAP3K110.80557631
62GRK60.79609488
63MAPK120.78842898
64TIE10.76018682
65MAP2K60.75203167
66PKN10.72937970
67CAMK2G0.72826760
68RIPK10.72619225
69DYRK1B0.72366667
70PDK20.70491939
71PRPF4B0.70058807
72PRKACG0.68148854
73TSSK60.67218129
74GSK3A0.64508763
75FGFR30.62715135
76GRK10.59006308
77PRKAA10.57478568
78STK100.57334154
79MAPK70.57301905
80CSK0.56138212
81BLK0.55074388
82PTK20.54533413
83CAMK1D0.54349993
84NEK60.53823005
85MAP2K10.53542236
86SGK30.51045316
87TRPM70.50388164
88TGFBR20.50150036
89IKBKE0.49935552
90PRKCQ0.48543334
91MST40.48249630
92PDPK10.48146209
93FGFR10.47132059
94MAP3K60.46769883
95MAP3K50.45289016
96MARK20.45097515
97FER0.43602433
98CSNK1G10.42608148
99EPHB20.42177699
100MAPKAPK30.40935052
101PAK20.40671110
102IGF1R0.40520088
103CSF1R0.40381880
104RET0.40089544
105MAP3K20.38958617
106MAP3K130.38472490
107ERBB30.38329768
108LATS20.38098108
109MAP2K20.37543167
110IRAK10.37465782
111CHUK0.35857740
112EGFR0.35653346
113MAP3K10.35649804
114GRK50.35085588
115EIF2AK30.34440101
116MTOR0.34044929
117IRAK20.33835748
118PIK3CA0.33452600
119PRKCG0.32459281
120SGK20.32088370
121EPHA40.31200713
122HCK0.30842566
123CDK120.30495417
124ICK0.30014227
125TAOK20.29572028
126PAK30.29555430
127CDK40.28794864
128PRKCE0.28441350
129SGK10.27283272
130ABL10.26012817
131BMX0.25716153
132NLK0.25567430
133SGK4940.25439386
134SGK2230.25439386
135PDK10.24994884
136PRKCA0.24220096
137CAMK40.23716986
138RPS6KA10.23153832
139DAPK30.22932227
140EEF2K0.21238661
141RPS6KB10.19221674
142MAPKAPK50.18356633
143EIF2AK20.17167653
144CAMK10.16820701
145BCR0.16425546
146RPS6KC10.14712157
147RPS6KL10.14712157
148TYRO30.13499453
149DYRK1A0.13363997

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.82613790
2Nitrogen metabolism_Homo sapiens_hsa009103.47025579
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29696664
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20276585
5Sphingolipid metabolism_Homo sapiens_hsa006003.03197165
6Arginine biosynthesis_Homo sapiens_hsa002202.97970695
7Complement and coagulation cascades_Homo sapiens_hsa046102.83712480
8Tryptophan metabolism_Homo sapiens_hsa003802.70691132
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.68244647
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62947359
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59711758
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57862531
13Fatty acid degradation_Homo sapiens_hsa000712.48304382
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41618094
15Butanoate metabolism_Homo sapiens_hsa006502.14371173
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12752630
17Peroxisome_Homo sapiens_hsa041462.12146020
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06353627
19GnRH signaling pathway_Homo sapiens_hsa049122.02302474
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.99758205
21Histidine metabolism_Homo sapiens_hsa003401.95950388
22Propanoate metabolism_Homo sapiens_hsa006401.92223332
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.92029802
24Circadian rhythm_Homo sapiens_hsa047101.89114296
25Chemical carcinogenesis_Homo sapiens_hsa052041.86532546
26PPAR signaling pathway_Homo sapiens_hsa033201.84906609
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84878207
28Long-term depression_Homo sapiens_hsa047301.80284810
29Fatty acid metabolism_Homo sapiens_hsa012121.78124178
30Retinol metabolism_Homo sapiens_hsa008301.75354692
31VEGF signaling pathway_Homo sapiens_hsa043701.75221138
32Staphylococcus aureus infection_Homo sapiens_hsa051501.75009631
33beta-Alanine metabolism_Homo sapiens_hsa004101.71524405
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.70115869
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69056207
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65496621
37Caffeine metabolism_Homo sapiens_hsa002321.63828744
38p53 signaling pathway_Homo sapiens_hsa041151.62943587
39Phenylalanine metabolism_Homo sapiens_hsa003601.57086161
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56237378
41Selenocompound metabolism_Homo sapiens_hsa004501.53879776
42Fatty acid elongation_Homo sapiens_hsa000621.52824322
43Tyrosine metabolism_Homo sapiens_hsa003501.50637426
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.50508580
45Bile secretion_Homo sapiens_hsa049761.46934404
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46770687
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44008016
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43692509
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36537065
50Sulfur metabolism_Homo sapiens_hsa009201.33941279
51Fat digestion and absorption_Homo sapiens_hsa049751.33608442
52Pyruvate metabolism_Homo sapiens_hsa006201.30597973
53ABC transporters_Homo sapiens_hsa020101.27728167
54Folate biosynthesis_Homo sapiens_hsa007901.26385988
55Starch and sucrose metabolism_Homo sapiens_hsa005001.26099777
56Steroid biosynthesis_Homo sapiens_hsa001001.25411804
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.25027652
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18313345
59Serotonergic synapse_Homo sapiens_hsa047261.15686440
60Biosynthesis of amino acids_Homo sapiens_hsa012301.13096008
61Vitamin B6 metabolism_Homo sapiens_hsa007501.12899805
62Choline metabolism in cancer_Homo sapiens_hsa052311.10233236
63Tight junction_Homo sapiens_hsa045301.09254945
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.08631192
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.08517337
66Carbon metabolism_Homo sapiens_hsa012001.06395663
67Dorso-ventral axis formation_Homo sapiens_hsa043201.06022517
68Ras signaling pathway_Homo sapiens_hsa040141.04383661
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02339331
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98889721
71Inositol phosphate metabolism_Homo sapiens_hsa005620.98054631
72Sulfur relay system_Homo sapiens_hsa041220.92875553
73Arginine and proline metabolism_Homo sapiens_hsa003300.90664412
74Vitamin digestion and absorption_Homo sapiens_hsa049770.88568763
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88439326
76Endocytosis_Homo sapiens_hsa041440.83982025
77Collecting duct acid secretion_Homo sapiens_hsa049660.83643640
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82647015
79MAPK signaling pathway_Homo sapiens_hsa040100.78392562
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78017586
81Lysine degradation_Homo sapiens_hsa003100.76913918
82Glutamatergic synapse_Homo sapiens_hsa047240.76418681
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.75159354
84Phototransduction_Homo sapiens_hsa047440.74760753
85ErbB signaling pathway_Homo sapiens_hsa040120.73683910
86One carbon pool by folate_Homo sapiens_hsa006700.72731115
87Glycerolipid metabolism_Homo sapiens_hsa005610.71857332
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71420525
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.68102689
90Platelet activation_Homo sapiens_hsa046110.67751996
91Pancreatic secretion_Homo sapiens_hsa049720.67664855
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65420168
93Glutathione metabolism_Homo sapiens_hsa004800.65176419
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64241311
95Oxytocin signaling pathway_Homo sapiens_hsa049210.63809065
96Renin secretion_Homo sapiens_hsa049240.62298017
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.61044082
98FoxO signaling pathway_Homo sapiens_hsa040680.60989627
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57307986
100Prion diseases_Homo sapiens_hsa050200.55839054
101Vibrio cholerae infection_Homo sapiens_hsa051100.55364228
102Fatty acid biosynthesis_Homo sapiens_hsa000610.53358024
103Pentose phosphate pathway_Homo sapiens_hsa000300.49443434
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48412034
105MicroRNAs in cancer_Homo sapiens_hsa052060.46613889
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46200168
107Metabolic pathways_Homo sapiens_hsa011000.45749271
108Acute myeloid leukemia_Homo sapiens_hsa052210.44362437
109Estrogen signaling pathway_Homo sapiens_hsa049150.43941243
110Renal cell carcinoma_Homo sapiens_hsa052110.43673423
111Mineral absorption_Homo sapiens_hsa049780.43416957
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42810379
113Melanogenesis_Homo sapiens_hsa049160.41714710
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41635054
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41343595
116Adherens junction_Homo sapiens_hsa045200.40316076
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40046691
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.38887640
119Hippo signaling pathway_Homo sapiens_hsa043900.37828694
120Toxoplasmosis_Homo sapiens_hsa051450.37629001
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37623914
122Linoleic acid metabolism_Homo sapiens_hsa005910.35106359
123Synaptic vesicle cycle_Homo sapiens_hsa047210.30942760
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30901533
125Influenza A_Homo sapiens_hsa051640.29053643
126Pertussis_Homo sapiens_hsa051330.28640325
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28544157
128Salmonella infection_Homo sapiens_hsa051320.28138068
129Gastric acid secretion_Homo sapiens_hsa049710.27473919
130Amphetamine addiction_Homo sapiens_hsa050310.26644411
131Rap1 signaling pathway_Homo sapiens_hsa040150.25197248
132Glioma_Homo sapiens_hsa052140.25049837
133Shigellosis_Homo sapiens_hsa051310.24678928
134Insulin resistance_Homo sapiens_hsa049310.23795356
135Axon guidance_Homo sapiens_hsa043600.23747339
136Calcium signaling pathway_Homo sapiens_hsa040200.23490766
137Tuberculosis_Homo sapiens_hsa051520.23103480
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.22071399
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.21737790
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20932482
141Galactose metabolism_Homo sapiens_hsa000520.20447128
142TGF-beta signaling pathway_Homo sapiens_hsa043500.20309070
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.19755853
144HIF-1 signaling pathway_Homo sapiens_hsa040660.19185416
145Notch signaling pathway_Homo sapiens_hsa043300.19068340
146Salivary secretion_Homo sapiens_hsa049700.18998946
147Long-term potentiation_Homo sapiens_hsa047200.17811258
148TNF signaling pathway_Homo sapiens_hsa046680.16221575
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.16075513
150Fructose and mannose metabolism_Homo sapiens_hsa000510.15733739
151ECM-receptor interaction_Homo sapiens_hsa045120.14989717
152Circadian entrainment_Homo sapiens_hsa047130.14869385
153Apoptosis_Homo sapiens_hsa042100.14261217
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12347102
155Glucagon signaling pathway_Homo sapiens_hsa049220.07746981
156AMPK signaling pathway_Homo sapiens_hsa041520.00090455
157Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2379101
158Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2187212
159Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2060148
160Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2027040
161Bladder cancer_Homo sapiens_hsa05219-0.1979110
162Renin-angiotensin system_Homo sapiens_hsa04614-0.1971132
163Protein digestion and absorption_Homo sapiens_hsa04974-0.1721611
164Amoebiasis_Homo sapiens_hsa05146-0.1669297
165Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1488066
166African trypanosomiasis_Homo sapiens_hsa05143-0.1403519
167Hepatitis C_Homo sapiens_hsa05160-0.1398545
168Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1385445
169Ether lipid metabolism_Homo sapiens_hsa00565-0.1308264
170Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1162162
171Regulation of autophagy_Homo sapiens_hsa04140-0.1129960
172Insulin signaling pathway_Homo sapiens_hsa04910-0.1064257
173Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0894168
174Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0788744
175Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0631647
176Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0529556
177Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0398079

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