SDK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.85019148
2cell proliferation in forebrain (GO:0021846)4.47726833
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.17144189
4neuronal stem cell maintenance (GO:0097150)4.15085240
5spinal cord association neuron differentiation (GO:0021527)4.14912132
6tongue development (GO:0043586)4.07720805
7midbrain development (GO:0030901)4.06572276
8detection of calcium ion (GO:0005513)4.02965463
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.89920731
10type B pancreatic cell development (GO:0003323)3.81402806
11positive regulation of gastrulation (GO:2000543)3.75759290
12response to pheromone (GO:0019236)3.65206853
13negative regulation of axon guidance (GO:1902668)3.55853821
14regulation of non-canonical Wnt signaling pathway (GO:2000050)3.55527599
15retinal ganglion cell axon guidance (GO:0031290)3.54694013
16establishment of tissue polarity (GO:0007164)3.50032911
17establishment of planar polarity (GO:0001736)3.50032911
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.49310055
19axon extension involved in axon guidance (GO:0048846)3.49310055
20pyrimidine nucleobase catabolic process (GO:0006208)3.45948202
21neuron fate determination (GO:0048664)3.43949683
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41848066
23spinal cord development (GO:0021510)3.40941532
24convergent extension (GO:0060026)3.40298226
25neuron cell-cell adhesion (GO:0007158)3.39901611
26insulin secretion (GO:0030073)3.38837745
27glandular epithelial cell development (GO:0002068)3.32558334
28negative regulation of norepinephrine secretion (GO:0010700)3.30468004
29neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.29868952
30limb development (GO:0060173)3.28849296
31appendage development (GO:0048736)3.28849296
32chemosensory behavior (GO:0007635)3.26735412
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26732657
34paraxial mesoderm development (GO:0048339)3.25297693
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22568142
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.22099605
37regulation of translation, ncRNA-mediated (GO:0045974)3.22099605
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22099605
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20860687
40kidney morphogenesis (GO:0060993)3.20717808
41apical protein localization (GO:0045176)3.16308081
42nonmotile primary cilium assembly (GO:0035058)3.16134791
43exocrine pancreas development (GO:0031017)3.16039390
44thalamus development (GO:0021794)3.15990631
45radial glial cell differentiation (GO:0060019)3.14544955
46camera-type eye morphogenesis (GO:0048593)3.11987915
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11687811
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07787137
49presynaptic membrane assembly (GO:0097105)3.06028850
50post-anal tail morphogenesis (GO:0036342)3.03729885
51lung-associated mesenchyme development (GO:0060484)3.03018622
52positive regulation of embryonic development (GO:0040019)3.02171781
53locomotory exploration behavior (GO:0035641)3.01855595
54negative regulation of axon extension involved in axon guidance (GO:0048843)3.01452949
55endocrine pancreas development (GO:0031018)3.00730013
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.99363880
57hindbrain development (GO:0030902)2.99186233
58artery development (GO:0060840)2.98046896
59regulation of synaptic vesicle exocytosis (GO:2000300)2.97340152
60startle response (GO:0001964)2.96170776
61peptide hormone processing (GO:0016486)2.91009802
62negative regulation of glycogen biosynthetic process (GO:0045719)2.90185121
63otic vesicle formation (GO:0030916)2.89283787
64intraciliary transport (GO:0042073)2.89016818
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89008239
66vocalization behavior (GO:0071625)2.88101381
67regulation of establishment of planar polarity (GO:0090175)2.87913962
68lens fiber cell development (GO:0070307)2.87431821
69positive regulation of neuroblast proliferation (GO:0002052)2.87141558
70regulation of axon guidance (GO:1902667)2.87083102
71neuronal ion channel clustering (GO:0045161)2.85065656
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84477641
73COPI coating of Golgi vesicle (GO:0048205)2.82155866
74Golgi transport vesicle coating (GO:0048200)2.82155866
75hematopoietic stem cell proliferation (GO:0071425)2.81802141
76inner ear receptor cell development (GO:0060119)2.81299063
77negative regulation of catecholamine secretion (GO:0033604)2.80681626
78calcium ion import (GO:0070509)2.79810988
79postsynaptic membrane organization (GO:0001941)2.78706661
80notochord development (GO:0030903)2.78404374
81synaptic vesicle maturation (GO:0016188)2.78065287
82cell surface receptor signaling pathway involved in heart development (GO:0061311)2.76854326
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76559014
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.76168361
85positive regulation of action potential (GO:0045760)2.75646512
86cell differentiation in spinal cord (GO:0021515)2.74492166
87negative regulation of osteoblast proliferation (GO:0033689)2.73938038
88non-canonical Wnt signaling pathway (GO:0035567)2.73561755
89regulation of gene silencing by RNA (GO:0060966)2.73536567
90regulation of posttranscriptional gene silencing (GO:0060147)2.73536567
91regulation of gene silencing by miRNA (GO:0060964)2.73536567
92glandular epithelial cell differentiation (GO:0002067)2.73531212
93cerebral cortex radially oriented cell migration (GO:0021799)2.71886691
94calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71040107
95outer ear morphogenesis (GO:0042473)2.70760370
96cAMP-mediated signaling (GO:0019933)2.69544428
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69030065
98dorsal/ventral axis specification (GO:0009950)2.68846012
99somatic stem cell division (GO:0048103)2.68637923
100dorsal/ventral neural tube patterning (GO:0021904)2.67864994
101negative chemotaxis (GO:0050919)2.67179216
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66706892
103neuron recognition (GO:0008038)2.66496637
104somite development (GO:0061053)2.66358559
105inner ear morphogenesis (GO:0042472)2.66091413
106negative regulation of glycogen metabolic process (GO:0070874)2.64264991
107regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.63995502
108regulation of somitogenesis (GO:0014807)2.63386706
109presynaptic membrane organization (GO:0097090)2.63236270
110digestive tract morphogenesis (GO:0048546)2.63203594
111chondrocyte development (GO:0002063)2.62680660
112olfactory bulb development (GO:0021772)2.62544754
113dendritic spine morphogenesis (GO:0060997)2.62259720
114regulation of mesoderm development (GO:2000380)2.62158875
115regulation of development, heterochronic (GO:0040034)2.61283675
116epithelial cilium movement (GO:0003351)2.61063166
117dorsal/ventral pattern formation (GO:0009953)2.60704605
118axonal fasciculation (GO:0007413)2.60093467
119cranial suture morphogenesis (GO:0060363)2.59996732
120protein localization to synapse (GO:0035418)2.58424405
121regulation of glutamate receptor signaling pathway (GO:1900449)2.57048175
122cranial nerve morphogenesis (GO:0021602)2.56649972
123regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56645597
124synaptic vesicle exocytosis (GO:0016079)2.56162594
125regulation of timing of cell differentiation (GO:0048505)2.55921075
126limb bud formation (GO:0060174)2.55878809
127innervation (GO:0060384)2.55708292
128regulation of smoothened signaling pathway (GO:0008589)2.55505926
129ephrin receptor signaling pathway (GO:0048013)2.55092894
130cardiovascular system development (GO:0072358)2.53358556
131nucleobase catabolic process (GO:0046113)2.53006558
132urinary tract smooth muscle contraction (GO:0014848)2.52884977
133head development (GO:0060322)2.51911311
134protein maturation by protein folding (GO:0022417)2.51444657
135pre-miRNA processing (GO:0031054)2.51298641
136peptide hormone secretion (GO:0030072)2.51081853
137forebrain neuron differentiation (GO:0021879)2.50939904
138myoblast fusion (GO:0007520)2.50564455
139renal system development (GO:0072001)2.50432478
140regulation of synaptic vesicle transport (GO:1902803)2.50365033
141mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48726918
142mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48726918
143positive regulation of synapse assembly (GO:0051965)2.47233547
144pituitary gland development (GO:0021983)2.47184089
145phosphorelay signal transduction system (GO:0000160)2.47016795
146negative regulation of epidermis development (GO:0045683)2.46805603
147neural precursor cell proliferation (GO:0061351)2.46661523
148ionotropic glutamate receptor signaling pathway (GO:0035235)2.46514427
149short-term memory (GO:0007614)2.45938827
150regulation of norepinephrine secretion (GO:0014061)2.45688024
151columnar/cuboidal epithelial cell development (GO:0002066)2.44735349
152negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44605938
153ganglion development (GO:0061548)2.43937730
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43763405
155central nervous system projection neuron axonogenesis (GO:0021952)2.43040542
156peptide secretion (GO:0002790)2.42508105
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41465669
158regulation of insulin secretion (GO:0050796)2.39077413
159positive regulation of meiosis (GO:0045836)2.39025964
160synaptic transmission, glutamatergic (GO:0035249)2.38705436
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.37515902
162positive regulation of hormone biosynthetic process (GO:0046886)2.37395868
163mesenchymal cell differentiation (GO:0048762)2.35542617
164smoothened signaling pathway (GO:0007224)2.35147882
165cerebellar Purkinje cell differentiation (GO:0021702)2.35137200
166prostate gland growth (GO:0060736)2.35079545
167transmission of nerve impulse (GO:0019226)2.34111794
168regulation of respiratory system process (GO:0044065)2.32979053
169regulation of synaptic transmission, GABAergic (GO:0032228)2.32404106
170nitric oxide mediated signal transduction (GO:0007263)2.31619686
171regulation of uterine smooth muscle contraction (GO:0070472)2.31390926
172cellular response to vitamin D (GO:0071305)2.30012621
173neuronal action potential propagation (GO:0019227)2.29930504
174pharyngeal system development (GO:0060037)2.28700133
175ER overload response (GO:0006983)2.27945292
176exploration behavior (GO:0035640)2.26740252
177spinal cord motor neuron differentiation (GO:0021522)2.23834422
178negative regulation of keratinocyte proliferation (GO:0010839)2.23808907
179regulation of neurotransmitter secretion (GO:0046928)2.23553722
180long-term memory (GO:0007616)2.23451118
181negative regulation of heart rate (GO:0010459)2.21568128
182regulation of beta-amyloid formation (GO:1902003)2.20852396
183dendrite morphogenesis (GO:0048813)2.20300269
184protein targeting to Golgi (GO:0000042)2.20142429
185cornea development in camera-type eye (GO:0061303)2.19882755
186synapse assembly (GO:0007416)2.19824405
187neuron-neuron synaptic transmission (GO:0007270)2.19478490
188regulation of peptide hormone secretion (GO:0090276)2.19124459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human4.15072532
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98612198
3GBX2_23144817_ChIP-Seq_PC3_Human3.56190703
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95067916
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80847763
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59107005
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.58503049
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57832088
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.57815707
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48054406
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47238942
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.42653679
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30762270
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29625918
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26944333
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26919569
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22456851
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22456851
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12232963
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.05619476
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03989037
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03042406
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00460257
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00036528
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97475696
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.97306638
27REST_21632747_ChIP-Seq_MESCs_Mouse1.92799869
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88729315
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87988124
30IGF1R_20145208_ChIP-Seq_DFB_Human1.87863650
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85981977
32DROSHA_22980978_ChIP-Seq_HELA_Human1.82530216
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80991012
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78088419
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77561155
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.75564885
37SMAD4_21799915_ChIP-Seq_A2780_Human1.72745650
38EWS_26573619_Chip-Seq_HEK293_Human1.72687827
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72573640
40AR_21572438_ChIP-Seq_LNCaP_Human1.72544931
41P300_19829295_ChIP-Seq_ESCs_Human1.67751224
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.65577214
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.65239449
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64895712
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62122304
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59529183
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.55960144
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55107335
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52983308
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52011407
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.51886907
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49713380
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.43566002
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42986335
55* STAT3_23295773_ChIP-Seq_U87_Human1.42773912
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41830588
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41402555
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40691686
59RNF2_27304074_Chip-Seq_NSC_Mouse1.38398335
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37876663
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37060340
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35101819
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33859425
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33165974
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32853674
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32853674
67* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32318037
68* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31884511
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28961977
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28233849
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.26848221
72* TCF4_23295773_ChIP-Seq_U87_Human1.26812767
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26383034
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.25483471
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25138877
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23248114
77TAF15_26573619_Chip-Seq_HEK293_Human1.23173816
78* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23075419
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22793275
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.22680623
81* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22558236
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.22436521
83P53_22387025_ChIP-Seq_ESCs_Mouse1.21255214
84FUS_26573619_Chip-Seq_HEK293_Human1.20947441
85VDR_22108803_ChIP-Seq_LS180_Human1.20904259
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20881216
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.19440409
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18671505
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18145816
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17221045
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16725673
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16586696
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16465650
94AHR_22903824_ChIP-Seq_MCF-7_Human1.15803738
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.15013712
96* AR_25329375_ChIP-Seq_VCAP_Human1.14926740
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14883903
98ZNF274_21170338_ChIP-Seq_K562_Hela1.14334077
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.13795746
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.13789990
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13757329
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13689591
103* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13500968
104* AR_19668381_ChIP-Seq_PC3_Human1.12592490
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.11443769
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11394311
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10691237
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10566173
109TP53_18474530_ChIP-ChIP_U2OS_Human1.10429395
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09868152
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.09089804
112* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08254126
113* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07887197
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07110715
115* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06451596
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.06376077
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06282369
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06168493
119* SOX9_26525672_Chip-Seq_HEART_Mouse1.05159882
120BCAT_22108803_ChIP-Seq_LS180_Human1.05144523
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.04289160
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.03598519
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03053271
124* SMAD3_21741376_ChIP-Seq_ESCs_Human1.02891622
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02691063
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.02555082
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02347451
128P300_18555785_Chip-Seq_ESCs_Mouse1.02206346
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02043695
130ER_23166858_ChIP-Seq_MCF-7_Human1.01927680
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01145612
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99333388
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99304667
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98835206
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98835206
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98835206
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97828564
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97706091
139CBP_20019798_ChIP-Seq_JUKART_Human0.96981142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.28906931
2MP0009780_abnormal_chondrocyte_physiolo3.18248179
3MP0003283_abnormal_digestive_organ3.02785098
4MP0010386_abnormal_urinary_bladder3.02418902
5MP0003122_maternal_imprinting2.91431689
6MP0003787_abnormal_imprinting2.60422198
7MP0005646_abnormal_pituitary_gland2.42609421
8MP0000678_abnormal_parathyroid_gland2.38836927
9MP0008789_abnormal_olfactory_epithelium2.36794799
10MP0004859_abnormal_synaptic_plasticity2.35135616
11MP0001293_anophthalmia2.31219751
12MP0009053_abnormal_anal_canal2.31121718
13MP0000566_synostosis2.30483028
14MP0002909_abnormal_adrenal_gland2.28797462
15MP0000537_abnormal_urethra_morphology2.24904272
16MP0004270_analgesia2.22662633
17MP0001188_hyperpigmentation2.19223894
18MP0005394_taste/olfaction_phenotype2.19144960
19MP0005499_abnormal_olfactory_system2.19144960
20MP0002693_abnormal_pancreas_physiology2.16880537
21MP0005379_endocrine/exocrine_gland_phen2.14691413
22MP0005645_abnormal_hypothalamus_physiol2.12184238
23MP0006292_abnormal_olfactory_placode2.11500913
24MP0002249_abnormal_larynx_morphology2.09755874
25MP0003136_yellow_coat_color2.09695708
26MP0002233_abnormal_nose_morphology2.07678712
27MP0005248_abnormal_Harderian_gland2.06402890
28MP0003938_abnormal_ear_development2.04734433
29MP0003937_abnormal_limbs/digits/tail_de1.99614242
30MP0003635_abnormal_synaptic_transmissio1.97443222
31MP0002735_abnormal_chemical_nociception1.91544036
32MP0003880_abnormal_central_pattern1.90846446
33MP0005423_abnormal_somatic_nervous1.84252682
34MP0002653_abnormal_ependyma_morphology1.82526574
35MP0001944_abnormal_pancreas_morphology1.76460027
36MP0002734_abnormal_mechanical_nocicepti1.75124676
37MP0001986_abnormal_taste_sensitivity1.74694220
38MP0002572_abnormal_emotion/affect_behav1.69932396
39MP0004133_heterotaxia1.64755060
40MP0002697_abnormal_eye_size1.62345703
41MP0001299_abnormal_eye_distance/1.59400343
42MP0002063_abnormal_learning/memory/cond1.59013254
43MP0005377_hearing/vestibular/ear_phenot1.58841455
44MP0003878_abnormal_ear_physiology1.58841455
45MP0003941_abnormal_skin_development1.58591373
46MP0001486_abnormal_startle_reflex1.58424521
47MP0009745_abnormal_behavioral_response1.56732849
48MP0004043_abnormal_pH_regulation1.54500091
49MP0005257_abnormal_intraocular_pressure1.54167393
50MP0002638_abnormal_pupillary_reflex1.53803149
51MP0003119_abnormal_digestive_system1.52258893
52MP0005503_abnormal_tendon_morphology1.49383931
53MP0002877_abnormal_melanocyte_morpholog1.48286834
54MP0006072_abnormal_retinal_apoptosis1.47199015
55MP0004145_abnormal_muscle_electrophysio1.46571410
56MP0001286_abnormal_eye_development1.45971584
57MP0006276_abnormal_autonomic_nervous1.45282383
58MP0003861_abnormal_nervous_system1.42568393
59MP0003121_genomic_imprinting1.41523954
60MP0000631_abnormal_neuroendocrine_gland1.41181770
61MP0002184_abnormal_innervation1.41157132
62MP0003879_abnormal_hair_cell1.39680454
63MP0009046_muscle_twitch1.38844856
64MP0002272_abnormal_nervous_system1.37724799
65MP0002557_abnormal_social/conspecific_i1.36432481
66MP0002938_white_spotting1.35964375
67MP0002064_seizures1.35161659
68MP0004134_abnormal_chest_morphology1.34247302
69MP0001984_abnormal_olfaction1.30937147
70MP0002896_abnormal_bone_mineralization1.30662804
71MP0000462_abnormal_digestive_system1.30435436
72MP0000778_abnormal_nervous_system1.29767280
73MP0000383_abnormal_hair_follicle1.28713562
74MP0001968_abnormal_touch/_nociception1.27800156
75MP0003385_abnormal_body_wall1.25584683
76MP0002111_abnormal_tail_morphology1.25320801
77MP0001970_abnormal_pain_threshold1.24846290
78MP0001270_distended_abdomen1.24104197
79MP0003890_abnormal_embryonic-extraembry1.22457874
80MP0001529_abnormal_vocalization1.21714789
81MP0002234_abnormal_pharynx_morphology1.17740376
82MP0002733_abnormal_thermal_nociception1.17352665
83MP0002092_abnormal_eye_morphology1.16431995
84MP0002067_abnormal_sensory_capabilities1.15897288
85MP0000013_abnormal_adipose_tissue1.15125105
86MP0001502_abnormal_circadian_rhythm1.14949324
87MP0000049_abnormal_middle_ear1.14420899
88MP0000432_abnormal_head_morphology1.11537712
89MP0000955_abnormal_spinal_cord1.11156145
90MP0002932_abnormal_joint_morphology1.11071194
91MP0003935_abnormal_craniofacial_develop1.10295714
92MP0002282_abnormal_trachea_morphology1.09766112
93MP0002751_abnormal_autonomic_nervous1.09062460
94MP0004742_abnormal_vestibular_system1.07409316
95MP0002152_abnormal_brain_morphology1.04174781
96MP0002822_catalepsy1.04128245
97MP0002116_abnormal_craniofacial_bone1.03673294
98MP0005253_abnormal_eye_physiology1.03212130
99MP0009250_abnormal_appendicular_skeleto1.01836273
100MP0000026_abnormal_inner_ear1.01621225
101MP0001963_abnormal_hearing_physiology1.01126644
102MP0004142_abnormal_muscle_tone1.00677290
103MP0004858_abnormal_nervous_system1.00337969
104MP0002163_abnormal_gland_morphology0.98696013
105MP0002752_abnormal_somatic_nervous0.98606785
106MP0008877_abnormal_DNA_methylation0.98600394
107MP0002084_abnormal_developmental_patter0.98559335
108MP0003183_abnormal_peptide_metabolism0.98329704
109MP0005187_abnormal_penis_morphology0.98224166
110MP0002177_abnormal_outer_ear0.98189318
111MP0002876_abnormal_thyroid_physiology0.97941417
112MP0001501_abnormal_sleep_pattern0.97900053
113MP0005391_vision/eye_phenotype0.97478817
114MP0003315_abnormal_perineum_morphology0.96633688
115MP0000534_abnormal_ureter_morphology0.96072361
116MP0002109_abnormal_limb_morphology0.95939225
117MP0000579_abnormal_nail_morphology0.94768680
118MP0000613_abnormal_salivary_gland0.94563724
119MP0000163_abnormal_cartilage_morphology0.93718797
120MP0002882_abnormal_neuron_morphology0.93512510
121MP0001346_abnormal_lacrimal_gland0.93207854
122MP0005409_darkened_coat_color0.92976248
123MP0000428_abnormal_craniofacial_morphol0.90910187
124MP0001440_abnormal_grooming_behavior0.90790208
125MP0003755_abnormal_palate_morphology0.90375911
126MP0005551_abnormal_eye_electrophysiolog0.89454367
127MP0000516_abnormal_urinary_system0.87775507
128MP0005367_renal/urinary_system_phenotyp0.87775507
129MP0003195_calcinosis0.86744262
130MP0002085_abnormal_embryonic_tissue0.85574319
131MP0005171_absent_coat_pigmentation0.85529191
132MP0001485_abnormal_pinna_reflex0.85275157
133MP0004885_abnormal_endolymph0.85193213
134MP0002098_abnormal_vibrissa_morphology0.84967864
135MP0008569_lethality_at_weaning0.84305109
136MP0003942_abnormal_urinary_system0.84202171
137MP0003567_abnormal_fetal_cardiomyocyte0.83996405
138MP0002108_abnormal_muscle_morphology0.83703786
139MP0000569_abnormal_digit_pigmentation0.83087102
140MP0000681_abnormal_thyroid_gland0.82660022
141MP0009379_abnormal_foot_pigmentation0.81699184
142MP0005220_abnormal_exocrine_pancreas0.81586781
143MP0002078_abnormal_glucose_homeostasis0.80899873
144MP0000762_abnormal_tongue_morphology0.80719909
145MP0002081_perinatal_lethality0.80094319
146MP0002102_abnormal_ear_morphology0.79904978
147MP0000538_abnormal_urinary_bladder0.79730245
148MP0005076_abnormal_cell_differentiation0.77901906
149MP0009703_decreased_birth_body0.72639453
150MP0005195_abnormal_posterior_eye0.72212814
151MP0001177_atelectasis0.68950871
152MP0009672_abnormal_birth_weight0.68764968
153MP0002089_abnormal_postnatal_growth/wei0.68652207
154MP0002114_abnormal_axial_skeleton0.67093426
155MP0005197_abnormal_uvea_morphology0.66116436

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.41049398
2Hyperinsulinemic hypoglycemia (HP:0000825)3.60750578
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.51994829
4Short 4th metacarpal (HP:0010044)3.51994829
5Hypoglycemic seizures (HP:0002173)3.51921925
6Symptomatic seizures (HP:0011145)3.43863364
7Epiphyseal dysplasia (HP:0002656)3.39166266
8Septo-optic dysplasia (HP:0100842)3.38947059
9Abnormality of calcium-phosphate metabolism (HP:0100530)3.35982708
10Insulin-resistant diabetes mellitus (HP:0000831)3.27750239
11High anterior hairline (HP:0009890)3.26016832
12Decreased circulating renin level (HP:0003351)3.17014634
13Rib fusion (HP:0000902)3.11482285
14Abnormality of the 4th metacarpal (HP:0010012)3.00393462
15Trigonocephaly (HP:0000243)2.98765460
16Focal motor seizures (HP:0011153)2.95680772
17Febrile seizures (HP:0002373)2.93657824
18Broad thumb (HP:0011304)2.92891425
19Osteomalacia (HP:0002749)2.86703778
20Hypoplastic ischia (HP:0003175)2.82627340
21Oligodactyly (HP:0012165)2.77965935
22Preaxial foot polydactyly (HP:0001841)2.74441095
23Midline defect of the nose (HP:0004122)2.69151216
24Esophageal atresia (HP:0002032)2.63986285
25Abnormality of the aortic arch (HP:0012303)2.63873870
26Flat capital femoral epiphysis (HP:0003370)2.63344533
27Unilateral renal agenesis (HP:0000122)2.61442979
28Anophthalmia (HP:0000528)2.59773131
29Agitation (HP:0000713)2.56929984
30Abnormality of the ischium (HP:0003174)2.54926108
31Absent eyebrow (HP:0002223)2.50760622
32Ectopic kidney (HP:0000086)2.50352161
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49193433
34Broad phalanges of the hand (HP:0009768)2.48903075
35Epileptic encephalopathy (HP:0200134)2.48253992
36Abnormality of the nasal septum (HP:0000419)2.47095595
37Broad finger (HP:0001500)2.43028036
38Abnormality of the labia minora (HP:0012880)2.42441396
39Oligodactyly (hands) (HP:0001180)2.40578795
40Abnormality of cochlea (HP:0000375)2.38991479
41Pancreatic islet-cell hyperplasia (HP:0004510)2.34701623
42Enlarged epiphyses (HP:0010580)2.32585699
43Nuclear cataract (HP:0100018)2.32505349
44Mesomelia (HP:0003027)2.30332081
45Broad phalanx (HP:0006009)2.29815802
46Abnormality of incisor morphology (HP:0011063)2.29468563
47Pancreatic fibrosis (HP:0100732)2.29289401
48Broad toe (HP:0001837)2.28430792
49Nephronophthisis (HP:0000090)2.28074820
50Broad hallux (HP:0010055)2.26707539
51Morphological abnormality of the inner ear (HP:0011390)2.25896119
52Pancreatic cysts (HP:0001737)2.25688481
53Abnormal pancreas size (HP:0012094)2.24749072
54Synostosis of carpal bones (HP:0005048)2.24575808
55Absent septum pellucidum (HP:0001331)2.24122539
56Large for gestational age (HP:0001520)2.22381919
57Renal dysplasia (HP:0000110)2.22236690
58Coronal craniosynostosis (HP:0004440)2.21651618
59Hypokalemia (HP:0002900)2.21437298
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.19841729
61Cutaneous finger syndactyly (HP:0010554)2.16761479
62Gastrointestinal atresia (HP:0002589)2.16760807
63Broad long bones (HP:0005622)2.15556904
64Renal hypoplasia (HP:0000089)2.14877046
65Partial duplication of thumb phalanx (HP:0009944)2.13912179
66EEG with generalized epileptiform discharges (HP:0011198)2.13600987
67Epileptiform EEG discharges (HP:0011182)2.12771472
68Mixed hearing impairment (HP:0000410)2.11440697
69Vitreoretinal degeneration (HP:0000655)2.11245893
70Abnormality of renin-angiotensin system (HP:0000847)2.10939569
71Hemivertebrae (HP:0002937)2.10399748
72Hyperglycemia (HP:0003074)2.10364207
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09931642
74Abnormality of the parietal bone (HP:0002696)2.09324306
75Zonular cataract (HP:0010920)2.06210424
76Hypoplastic labia majora (HP:0000059)2.03845025
77Split foot (HP:0001839)2.03365337
78Absent/shortened dynein arms (HP:0200106)2.03256186
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.03256186
80Short 5th finger (HP:0009237)2.02897983
81Delayed epiphyseal ossification (HP:0002663)2.01867086
82Generalized tonic-clonic seizures (HP:0002069)2.01433376
83Congenital sensorineural hearing impairment (HP:0008527)2.00503239
84Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00430143
85Hypsarrhythmia (HP:0002521)2.00293961
86Maternal diabetes (HP:0009800)1.99455610
87Preaxial hand polydactyly (HP:0001177)1.99370203
88Hypoplastic pelvis (HP:0008839)1.98498183
89Abnormality of the renal medulla (HP:0100957)1.98168523
90Metaphyseal irregularity (HP:0003025)1.98027073
91Abnormality of the diencephalon (HP:0010662)1.97933437
92Papilledema (HP:0001085)1.97241210
93Focal seizures (HP:0007359)1.96042499
94Atonic seizures (HP:0010819)1.93930167
95Facial hemangioma (HP:0000329)1.92322199
96Abnormality of the septum pellucidum (HP:0007375)1.92081331
97Abnormality of the labia majora (HP:0012881)1.92037627
98Abnormality of potassium homeostasis (HP:0011042)1.91975908
99Progressive cerebellar ataxia (HP:0002073)1.91745032
100Hyperphosphatemia (HP:0002905)1.91650541
101Partial duplication of the phalanx of hand (HP:0009999)1.90956998
102Aqueductal stenosis (HP:0002410)1.90480492
103Abdominal situs inversus (HP:0003363)1.89806658
104Abnormality of abdominal situs (HP:0011620)1.89806658
105Anencephaly (HP:0002323)1.89748673
106Cutaneous syndactyly (HP:0012725)1.89101735
107Abnormal number of incisors (HP:0011064)1.88852011
108Hepatoblastoma (HP:0002884)1.88812030
109Vaginal atresia (HP:0000148)1.88616838
110Labial hypoplasia (HP:0000066)1.88069695
111Postaxial foot polydactyly (HP:0001830)1.87708866
112Excessive salivation (HP:0003781)1.87616253
113Drooling (HP:0002307)1.87616253
114Neonatal short-limb short stature (HP:0008921)1.87434180
115Cystic liver disease (HP:0006706)1.86289268
116Abnormality of the middle phalanges of the toes (HP:0010183)1.85975924
117Bilateral microphthalmos (HP:0007633)1.85580658
118Fibular hypoplasia (HP:0003038)1.82872905
119Hypoplasia of the ulna (HP:0003022)1.81797677
120Obstructive sleep apnea (HP:0002870)1.81553420
121Colon cancer (HP:0003003)1.81319038
122Postaxial hand polydactyly (HP:0001162)1.81035365
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.80911464
124Coarctation of aorta (HP:0001680)1.79886023
125Supernumerary ribs (HP:0005815)1.79660067
126Hyperkalemia (HP:0002153)1.79469892
127Bell-shaped thorax (HP:0001591)1.79300507
128Abnormality of the pancreatic islet cells (HP:0006476)1.79189537
129Abnormality of endocrine pancreas physiology (HP:0012093)1.79189537
130Morphological abnormality of the middle ear (HP:0008609)1.78973865
131Molar tooth sign on MRI (HP:0002419)1.78638358
132Abnormality of midbrain morphology (HP:0002418)1.78638358
133Intestinal atresia (HP:0011100)1.78388233
134Abnormality of the intervertebral disk (HP:0005108)1.78224526
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.77630827
136Sclerocornea (HP:0000647)1.76068149
137Visual hallucinations (HP:0002367)1.75563018
138Protruding tongue (HP:0010808)1.75496412
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.75430632
140Hypoplasia of the fovea (HP:0007750)1.75430632
141Patellar aplasia (HP:0006443)1.75279938
142Supernumerary bones of the axial skeleton (HP:0009144)1.75134490
143Hypothermia (HP:0002045)1.74706426
144Shawl scrotum (HP:0000049)1.73153073
145Thin ribs (HP:0000883)1.73084419
146Triphalangeal thumb (HP:0001199)1.71452379
147Hypoplastic female external genitalia (HP:0012815)1.71116698
148Absent speech (HP:0001344)1.69899402
149Widely patent fontanelles and sutures (HP:0004492)1.69012526
150Abnormality of the lacrimal duct (HP:0011481)1.68863300
151Exostoses (HP:0100777)1.67481294
152Submucous cleft hard palate (HP:0000176)1.67295873
153Abnormality of the nasolacrimal system (HP:0000614)1.66120429
154Small epiphyses (HP:0010585)1.65988792
155Alacrima (HP:0000522)1.65178196
156Blue irides (HP:0000635)1.64892672
157Aplasia/Hypoplasia of the lens (HP:0008063)1.64500335
158Tracheomalacia (HP:0002779)1.63582863
159Abnormality of the metopic suture (HP:0005556)1.63498567
160True hermaphroditism (HP:0010459)1.63486216
161Chronic hepatic failure (HP:0100626)1.61303787
162Abnormality of the right ventricle (HP:0001707)1.61155989
163Increased circulating renin level (HP:0000848)1.60890398
164Conjugated hyperbilirubinemia (HP:0002908)1.59744170
165Bifid tongue (HP:0010297)1.59543927
166Aplasia involving bones of the extremities (HP:0009825)1.57628217
167Aplasia involving bones of the upper limbs (HP:0009823)1.57628217
168Aplasia of the phalanges of the hand (HP:0009802)1.57628217
169Abnormal ciliary motility (HP:0012262)1.56761470
170Decreased central vision (HP:0007663)1.56468713
171Optic nerve hypoplasia (HP:0000609)1.56461039
172Abnormality of salivation (HP:0100755)1.56222462
173Abnormality of the pubic bones (HP:0003172)1.56078320
174Sleep apnea (HP:0010535)1.53864890
175Absence seizures (HP:0002121)1.52469846
176Thoracolumbar scoliosis (HP:0002944)1.51905427
177Mild short stature (HP:0003502)1.51640772
178Medial flaring of the eyebrow (HP:0010747)1.51239168
179Hyperventilation (HP:0002883)1.50923491
180Genital tract atresia (HP:0001827)1.50149542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.03194089
2NTRK33.51935032
3CASK2.99786953
4MAP3K102.63079817
5PRKD32.56940697
6PASK2.49995309
7MKNK12.18772747
8TNIK2.17100040
9MAP2K72.13786107
10MARK12.04933336
11TAOK31.94388158
12MAP3K41.78216620
13CAMK1G1.78095733
14MKNK21.68929858
15SIK31.67516825
16MAPK131.66016271
17MAPK151.65531063
18NTRK11.56799413
19AKT31.56637327
20TYRO31.52148914
21HIPK21.52065893
22EPHA41.49936606
23STK391.42547113
24CDC71.40284200
25CAMKK21.39689356
26IRAK21.39322509
27NTRK21.38451951
28PNCK1.32842213
29EPHA31.32500161
30SRPK11.31852314
31TGFBR11.31297705
32STK38L1.31018186
33UHMK11.30753458
34MAP4K21.30005695
35PRPF4B1.28477780
36CDC42BPA1.27641638
37BRD41.26598829
38WEE11.23277348
39NEK61.22524536
40SIK21.20984026
41SGK21.19423886
42IRAK11.19022368
43MAP3K21.17290213
44SIK11.16928286
45WNK41.14502407
46PRKCE1.13510459
47DYRK31.13279183
48BMPR1B1.12927192
49PRKCH1.12784362
50CDK31.12171066
51MAP3K11.09741663
52SGK2231.08771571
53SGK4941.08771571
54DDR21.08345174
55LATS11.07768729
56VRK21.06011447
57BMPR21.05306908
58FLT30.94227291
59CAMK1D0.94141985
60WNK10.92550177
61EIF2AK20.92342412
62DAPK20.90603952
63NUAK10.89896131
64FGFR10.88573386
65FRK0.87366386
66CSNK1G10.84597391
67ADRBK20.83208937
68IRAK30.83164939
69CDK190.82563577
70PLK40.81704662
71VRK10.80929398
72MARK20.79944599
73ATR0.79503288
74CHEK20.79401698
75ZAK0.78963970
76CCNB10.78684520
77GRK50.78523986
78ERBB20.77993869
79CDK50.77900795
80SGK30.77328319
81PRKD20.76302369
82NEK20.76110153
83SGK10.75828674
84ERBB30.75510222
85CSNK1G20.74714329
86CDK120.74552051
87PAK30.73135579
88FER0.72258465
89PLK20.71356804
90ADRBK10.71249187
91DYRK1A0.71224550
92PDGFRA0.70841788
93EPHB20.70456399
94CSNK1G30.69935318
95CAMKK10.69373698
96MAP3K70.69019011
97MINK10.68620734
98EEF2K0.67600440
99TAF10.66301373
100CAMK10.65356933
101WNK30.64623759
102STK110.64377618
103CAMK2A0.64351154
104IRAK40.64307941
105PINK10.64256379
106NME10.62143331
107BCR0.59230961
108TRIM280.59053833
109RPS6KA60.58689046
110PRKCG0.58036742
111FGFR20.55124647
112MAP2K40.54754693
113YES10.53752074
114ATM0.53060501
115PAK60.52642750
116FES0.52481539
117CAMK2D0.51846044
118PRKG10.51300143
119PLK30.50363824
120DYRK1B0.49145840
121RIPK40.48571231
122CSNK1A1L0.48432669
123RPS6KC10.48417696
124RPS6KL10.48417696
125STK30.48378434
126DYRK20.47952854
127RPS6KA40.47178313
128GRK10.46793721
129PKN10.45999052
130PRKACA0.44621967
131MAPK70.43493216
132CDK10.42980528
133TTK0.42867961
134CDK20.42014060
135PRKAA10.41491552
136PLK10.41138701
137STK240.40951822
138CSNK1A10.40897778
139KSR10.40828445
140RET0.40423247
141PTK20.39575852
142CAMK40.38839961
143CAMK2B0.37904826
144FGFR30.37429657
145NLK0.36885405

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.19612013
2Insulin secretion_Homo sapiens_hsa049113.00249754
3Hippo signaling pathway_Homo sapiens_hsa043902.81591500
4Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.50841925
5Nicotine addiction_Homo sapiens_hsa050332.39091643
6Type II diabetes mellitus_Homo sapiens_hsa049302.25828838
7Taste transduction_Homo sapiens_hsa047422.23470512
8Ribosome_Homo sapiens_hsa030102.04823091
9Fanconi anemia pathway_Homo sapiens_hsa034602.03120949
10Morphine addiction_Homo sapiens_hsa050321.93575948
11Notch signaling pathway_Homo sapiens_hsa043301.92187168
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89722531
13GABAergic synapse_Homo sapiens_hsa047271.87053462
14Circadian entrainment_Homo sapiens_hsa047131.86383502
15Type I diabetes mellitus_Homo sapiens_hsa049401.86214366
16Amphetamine addiction_Homo sapiens_hsa050311.85760204
17Serotonergic synapse_Homo sapiens_hsa047261.75274760
18Homologous recombination_Homo sapiens_hsa034401.74706734
19Cocaine addiction_Homo sapiens_hsa050301.72034996
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71363073
21Synaptic vesicle cycle_Homo sapiens_hsa047211.70597719
22Lysine degradation_Homo sapiens_hsa003101.69542890
23Glutamatergic synapse_Homo sapiens_hsa047241.69431154
24Protein export_Homo sapiens_hsa030601.67007029
25Non-homologous end-joining_Homo sapiens_hsa034501.65406893
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62412800
27TGF-beta signaling pathway_Homo sapiens_hsa043501.61458553
28Cholinergic synapse_Homo sapiens_hsa047251.59177003
29Olfactory transduction_Homo sapiens_hsa047401.52186515
30Long-term potentiation_Homo sapiens_hsa047201.52019934
31Dopaminergic synapse_Homo sapiens_hsa047281.50145384
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45103665
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44279330
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27622268
35Renin secretion_Homo sapiens_hsa049241.25623876
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25609239
37Salivary secretion_Homo sapiens_hsa049701.19159820
38Phototransduction_Homo sapiens_hsa047441.17623698
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16149716
40Adherens junction_Homo sapiens_hsa045201.14758392
41cAMP signaling pathway_Homo sapiens_hsa040241.14108536
42Pancreatic secretion_Homo sapiens_hsa049721.13471158
43mRNA surveillance pathway_Homo sapiens_hsa030151.13237686
44Nitrogen metabolism_Homo sapiens_hsa009101.11075540
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10806201
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10788422
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10647879
48Calcium signaling pathway_Homo sapiens_hsa040201.10336929
49RNA degradation_Homo sapiens_hsa030181.10145729
50Basal transcription factors_Homo sapiens_hsa030221.09691466
51Long-term depression_Homo sapiens_hsa047301.09069529
52Hedgehog signaling pathway_Homo sapiens_hsa043401.08871132
53Steroid biosynthesis_Homo sapiens_hsa001001.08506782
54Mismatch repair_Homo sapiens_hsa034301.08197889
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07242234
56Axon guidance_Homo sapiens_hsa043601.07190344
57Vibrio cholerae infection_Homo sapiens_hsa051101.06422435
58Spliceosome_Homo sapiens_hsa030401.05892758
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04021721
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03891910
61Cardiac muscle contraction_Homo sapiens_hsa042601.02943522
62Sulfur metabolism_Homo sapiens_hsa009201.02100872
63Gastric acid secretion_Homo sapiens_hsa049711.01488034
64MicroRNAs in cancer_Homo sapiens_hsa052060.99250131
65Linoleic acid metabolism_Homo sapiens_hsa005910.98145252
66Melanogenesis_Homo sapiens_hsa049160.97565717
67Pathways in cancer_Homo sapiens_hsa052000.97103028
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96384139
69Cell cycle_Homo sapiens_hsa041100.94915944
70Butanoate metabolism_Homo sapiens_hsa006500.94875783
71RNA polymerase_Homo sapiens_hsa030200.94325242
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93718478
73Oxytocin signaling pathway_Homo sapiens_hsa049210.93653226
74Wnt signaling pathway_Homo sapiens_hsa043100.92921613
75Dorso-ventral axis formation_Homo sapiens_hsa043200.91590920
76Protein digestion and absorption_Homo sapiens_hsa049740.90747348
77Base excision repair_Homo sapiens_hsa034100.89613975
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89308321
79Basal cell carcinoma_Homo sapiens_hsa052170.88125521
80Estrogen signaling pathway_Homo sapiens_hsa049150.88092585
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.86436342
82Nucleotide excision repair_Homo sapiens_hsa034200.86187333
83Circadian rhythm_Homo sapiens_hsa047100.85279056
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85276473
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84519313
86Collecting duct acid secretion_Homo sapiens_hsa049660.84091343
87GnRH signaling pathway_Homo sapiens_hsa049120.83461721
88Ovarian steroidogenesis_Homo sapiens_hsa049130.83280347
89Colorectal cancer_Homo sapiens_hsa052100.83170638
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81841619
91Sphingolipid metabolism_Homo sapiens_hsa006000.81137445
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80423802
93DNA replication_Homo sapiens_hsa030300.79898062
94ErbB signaling pathway_Homo sapiens_hsa040120.79548402
95Tight junction_Homo sapiens_hsa045300.78375616
96Thyroid hormone synthesis_Homo sapiens_hsa049180.77767247
97RNA transport_Homo sapiens_hsa030130.77061901
98Gap junction_Homo sapiens_hsa045400.75389735
99Propanoate metabolism_Homo sapiens_hsa006400.75282036
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74595237
101Prolactin signaling pathway_Homo sapiens_hsa049170.74006183
102Ether lipid metabolism_Homo sapiens_hsa005650.73222995
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.72001431
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71329366
105Dilated cardiomyopathy_Homo sapiens_hsa054140.70610503
106Glioma_Homo sapiens_hsa052140.68195854
107Huntingtons disease_Homo sapiens_hsa050160.67571718
108Ras signaling pathway_Homo sapiens_hsa040140.67088630
109MAPK signaling pathway_Homo sapiens_hsa040100.65558900
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60286452
111N-Glycan biosynthesis_Homo sapiens_hsa005100.59990861
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59942337
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58059797
114Endometrial cancer_Homo sapiens_hsa052130.57957132
115Prostate cancer_Homo sapiens_hsa052150.57474485
116Alcoholism_Homo sapiens_hsa050340.56596043
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56481492
118Glucagon signaling pathway_Homo sapiens_hsa049220.53928058
119Choline metabolism in cancer_Homo sapiens_hsa052310.53040184
120Melanoma_Homo sapiens_hsa052180.52921338
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52775593
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52360478
123ECM-receptor interaction_Homo sapiens_hsa045120.51921379
124Small cell lung cancer_Homo sapiens_hsa052220.51038995
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50842546
126p53 signaling pathway_Homo sapiens_hsa041150.50623283
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49274463
128Inositol phosphate metabolism_Homo sapiens_hsa005620.48018573
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.47479846
130Lysosome_Homo sapiens_hsa041420.47463378
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45885644
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.45359842
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43694922
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42821451
135Parkinsons disease_Homo sapiens_hsa050120.42330294
136Oocyte meiosis_Homo sapiens_hsa041140.42224920
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42117274
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41130362
139Regulation of autophagy_Homo sapiens_hsa041400.40336316
140Chemokine signaling pathway_Homo sapiens_hsa040620.40025404
141Rheumatoid arthritis_Homo sapiens_hsa053230.39894920
142Insulin resistance_Homo sapiens_hsa049310.39396475
143Rap1 signaling pathway_Homo sapiens_hsa040150.36515348
144Prion diseases_Homo sapiens_hsa050200.35178861
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34481342

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