SDHC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)6.34822709
2lysine metabolic process (GO:0006553)5.97040632
3lysine catabolic process (GO:0006554)5.97040632
4fatty acid beta-oxidation (GO:0006635)5.14481854
52-oxoglutarate metabolic process (GO:0006103)5.06160057
6NADH metabolic process (GO:0006734)5.03419743
7glyoxylate metabolic process (GO:0046487)4.89338089
8aspartate family amino acid catabolic process (GO:0009068)4.86563099
9regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.72992676
10carnitine shuttle (GO:0006853)4.69731192
11branched-chain amino acid catabolic process (GO:0009083)4.63368770
12fatty acid transmembrane transport (GO:1902001)4.61994505
13oxidative phosphorylation (GO:0006119)4.61972636
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.61110478
15L-phenylalanine metabolic process (GO:0006558)4.61110478
16tricarboxylic acid metabolic process (GO:0072350)4.56680223
17fatty acid oxidation (GO:0019395)4.56522121
18regulation of sequestering of triglyceride (GO:0010889)4.51624568
19lipid oxidation (GO:0034440)4.47409517
20succinate metabolic process (GO:0006105)4.45595894
21fatty acid catabolic process (GO:0009062)4.45484947
22short-chain fatty acid metabolic process (GO:0046459)4.45310741
23oxaloacetate metabolic process (GO:0006107)4.42728126
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.41201686
25branched-chain amino acid metabolic process (GO:0009081)4.31932055
26sarcomere organization (GO:0045214)4.28833597
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.26786059
28L-phenylalanine catabolic process (GO:0006559)4.26786059
29acetyl-CoA metabolic process (GO:0006084)4.25875211
30* respiratory electron transport chain (GO:0022904)4.19380557
31regulation of acyl-CoA biosynthetic process (GO:0050812)4.17880633
32valine metabolic process (GO:0006573)4.17810200
33amino-acid betaine metabolic process (GO:0006577)4.15434536
34cellular ketone body metabolic process (GO:0046950)4.12980676
35regulation of fatty acid oxidation (GO:0046320)4.11504099
36ATP synthesis coupled proton transport (GO:0015986)4.11166721
37energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11166721
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09511504
39carnitine metabolic process (GO:0009437)4.07127730
40* electron transport chain (GO:0022900)4.06959635
41monocarboxylic acid catabolic process (GO:0072329)4.01557554
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97170654
43regulation of coenzyme metabolic process (GO:0051196)3.95836214
44regulation of cofactor metabolic process (GO:0051193)3.95836214
45cysteine metabolic process (GO:0006534)3.90092944
46positive regulation of fatty acid oxidation (GO:0046321)3.81997013
47viral transcription (GO:0019083)3.81173483
48biotin metabolic process (GO:0006768)3.79141912
49kynurenine metabolic process (GO:0070189)3.76247377
50alpha-linolenic acid metabolic process (GO:0036109)3.75212023
51sulfur amino acid catabolic process (GO:0000098)3.71531686
52aromatic amino acid family catabolic process (GO:0009074)3.69782872
53translational termination (GO:0006415)3.66923553
54carnitine transport (GO:0015879)3.64380322
55amino-acid betaine transport (GO:0015838)3.64380322
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.62291685
57potassium ion import (GO:0010107)3.61116842
58muscle filament sliding (GO:0030049)3.60253747
59actin-myosin filament sliding (GO:0033275)3.60253747
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.59941030
61carnitine transmembrane transport (GO:1902603)3.59922529
62ethanol oxidation (GO:0006069)3.58674828
63regulation of triglyceride catabolic process (GO:0010896)3.57469405
64ketone body metabolic process (GO:1902224)3.56048119
65cardiac myofibril assembly (GO:0055003)3.55139619
66organic acid catabolic process (GO:0016054)3.46245268
67carboxylic acid catabolic process (GO:0046395)3.46245268
68serine family amino acid catabolic process (GO:0009071)3.45200987
69alpha-amino acid catabolic process (GO:1901606)3.40218603
70response to pheromone (GO:0019236)3.39215023
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39204036
72cellular amino acid catabolic process (GO:0009063)3.36854615
73creatine metabolic process (GO:0006600)3.36300669
74negative regulation of fatty acid biosynthetic process (GO:0045717)3.32104503
75ribosomal small subunit biogenesis (GO:0042274)3.30510055
76tryptophan catabolic process (GO:0006569)3.25689258
77indole-containing compound catabolic process (GO:0042436)3.25689258
78indolalkylamine catabolic process (GO:0046218)3.25689258
79homocysteine metabolic process (GO:0050667)3.24674326
80sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23750082
81regulation of sulfur metabolic process (GO:0042762)3.23198245
82quaternary ammonium group transport (GO:0015697)3.22477958
83response to mercury ion (GO:0046689)3.22043510
84myofibril assembly (GO:0030239)3.20374489
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19062369
86regulation of fatty acid beta-oxidation (GO:0031998)3.18583576
87glycine metabolic process (GO:0006544)3.15162001
88bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14535885
89cellular modified amino acid catabolic process (GO:0042219)3.08350692
90bile acid biosynthetic process (GO:0006699)3.08141869
91serine family amino acid metabolic process (GO:0009069)3.07277731
92NAD metabolic process (GO:0019674)3.06339751
93regulation of skeletal muscle contraction (GO:0014819)3.04177812
944-hydroxyproline metabolic process (GO:0019471)3.03868614
95negative regulation of fatty acid metabolic process (GO:0045922)3.03741563
96tryptophan metabolic process (GO:0006568)3.02789640
97exogenous drug catabolic process (GO:0042738)3.01987655
98dicarboxylic acid metabolic process (GO:0043648)3.01318537
99ubiquinone biosynthetic process (GO:0006744)3.00635746
100quinone biosynthetic process (GO:1901663)3.00635746
101cardiac muscle contraction (GO:0060048)2.99882676
102coenzyme catabolic process (GO:0009109)2.98094228
103thioester metabolic process (GO:0035383)2.95956053
104acyl-CoA metabolic process (GO:0006637)2.95956053
105gluconeogenesis (GO:0006094)2.95379378
106neurotransmitter catabolic process (GO:0042135)2.94776910
107cardiac muscle cell development (GO:0055013)2.92833660
108plasma membrane repair (GO:0001778)2.92688774
109translational elongation (GO:0006414)2.91179919
110regulation of cholesterol metabolic process (GO:0090181)2.90281509
111cellular protein complex disassembly (GO:0043624)2.89917344
112fatty acid homeostasis (GO:0055089)2.88119788
113small molecule catabolic process (GO:0044282)2.87864827
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87794859
115cotranslational protein targeting to membrane (GO:0006613)2.86267228
116protein targeting to ER (GO:0045047)2.85913010
117histone-serine phosphorylation (GO:0035404)2.84205989
118behavioral response to nicotine (GO:0035095)2.82616197
119flavonoid metabolic process (GO:0009812)2.80029601
120regulation of histone phosphorylation (GO:0033127)2.78397450
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77786128
122phenol-containing compound catabolic process (GO:0019336)2.74657526
123actin-mediated cell contraction (GO:0070252)2.74015830
124protein localization to endoplasmic reticulum (GO:0070972)2.67703796
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65655931
126primary alcohol catabolic process (GO:0034310)2.64726028
127L-methionine salvage (GO:0071267)2.62941919
128L-methionine biosynthetic process (GO:0071265)2.62941919
129amino acid salvage (GO:0043102)2.62941919
130viral life cycle (GO:0019058)2.60326578
131cellular potassium ion homeostasis (GO:0030007)2.59030931
132striated muscle contraction (GO:0006941)2.58155455
133macroautophagy (GO:0016236)2.56413885
134negative regulation of leukocyte chemotaxis (GO:0002689)2.52932860
135cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52239969
136ethanol metabolic process (GO:0006067)2.51356685
137chaperone-mediated protein complex assembly (GO:0051131)2.50761982
138protein complex disassembly (GO:0043241)2.50508226
139mitochondrion morphogenesis (GO:0070584)2.47413203
140sodium ion export (GO:0071436)2.46622396
141sulfur amino acid biosynthetic process (GO:0000097)2.46352757
142drug catabolic process (GO:0042737)2.45956387
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.45485032
144regulation of translational fidelity (GO:0006450)2.45366510
145response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44816355
146axon ensheathment in central nervous system (GO:0032291)2.44362351
147central nervous system myelination (GO:0022010)2.44362351
148cochlea morphogenesis (GO:0090103)2.41846326
149regulation of cellular respiration (GO:0043457)2.40295713
150gamma-aminobutyric acid transport (GO:0015812)2.39143641
151serine family amino acid biosynthetic process (GO:0009070)2.36347833
152skeletal muscle contraction (GO:0003009)2.35792243
153methionine biosynthetic process (GO:0009086)2.34975922
154macromolecular complex disassembly (GO:0032984)2.33438544
155membrane repolarization (GO:0086009)2.33053609
156positive regulation of sodium ion transmembrane transport (GO:1902307)2.32846948
157notochord development (GO:0030903)2.31423590
158skeletal muscle adaptation (GO:0043501)2.30753861
159polyketide metabolic process (GO:0030638)2.29801443
160doxorubicin metabolic process (GO:0044598)2.29801443
161daunorubicin metabolic process (GO:0044597)2.29801443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.82258586
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.46596401
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.01953778
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68123720
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.29653822
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.68007514
7* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.26186047
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12845895
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98897384
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97477183
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.84364508
12EZH2_22144423_ChIP-Seq_EOC_Human2.52351408
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39397777
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36568211
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30812760
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.26109587
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.24801304
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23786426
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.12849892
20CLOCK_20551151_ChIP-Seq_293T_Human2.12326649
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.10921316
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93815430
23* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75561360
24ZNF263_19887448_ChIP-Seq_K562_Human1.71980263
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70585378
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69134633
27AR_21572438_ChIP-Seq_LNCaP_Human1.67233412
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.58881162
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57351542
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.56451016
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56080598
32* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55048006
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52568153
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.50721957
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.50379357
36TBX20_22328084_ChIP-Seq_HEART_Mouse1.48626264
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.48626264
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47739811
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46259317
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.46257402
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44850522
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44022799
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43993807
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.42659853
45CTCF_27219007_Chip-Seq_Bcells_Human1.42117662
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41794507
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.39818349
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39505443
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35849079
50GATA4_21415370_ChIP-Seq_HL-1_Mouse1.29561750
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27742146
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27117341
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27012458
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25192955
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24558500
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.22691141
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21843245
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21843245
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21138415
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20589039
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19613841
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.17133032
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15702497
64* DROSHA_22980978_ChIP-Seq_HELA_Human1.15366638
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.14862123
66SMC4_20622854_ChIP-Seq_HELA_Human1.14808447
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14389432
68PHF8_20622854_ChIP-Seq_HELA_Human1.14041638
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13748965
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10905257
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10657265
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08605973
73DCP1A_22483619_ChIP-Seq_HELA_Human1.06980257
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06934997
75* SA1_27219007_Chip-Seq_Bcells_Human1.06709707
76* GABP_17652178_ChIP-ChIP_JURKAT_Human1.06499940
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05639207
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04989126
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04149102
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03928456
81LXR_22292898_ChIP-Seq_THP-1_Human1.03903492
82ATF3_27146783_Chip-Seq_COLON_Human1.03830672
83GATA1_22025678_ChIP-Seq_K562_Human1.03566234
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.02630648
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01303957
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.00959548
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00264864
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99661533
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99521278
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99246222
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98289580
92CTCF_20526341_ChIP-Seq_ESCs_Human0.97553937
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96502011
94ERA_21632823_ChIP-Seq_H3396_Human0.96330061
95JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96150089
96P53_21459846_ChIP-Seq_SAOS-2_Human0.95690595
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95400037
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95082847
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94775695
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94329416
101E2F1_20622854_ChIP-Seq_HELA_Human0.94235797
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94062760
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93711022
104EP300_21415370_ChIP-Seq_HL-1_Mouse0.93588723
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93481835
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.93174877
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92991443
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92763540
109MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92154723
110RACK7_27058665_Chip-Seq_MCF-7_Human0.92038787
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92013914
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91053794
113BCL6_27268052_Chip-Seq_Bcells_Human0.90670768
114* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90485025
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90065636
116CREB1_26743006_Chip-Seq_LNCaP_Human0.89759245
117REST_21632747_ChIP-Seq_MESCs_Mouse0.89738364
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88801566
119* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88344934
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87743592
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87451573
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87314629
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87272228
124THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87125624
125TP63_22573176_ChIP-Seq_HFKS_Human0.86585544
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86335150
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.86333966
128GATA4_25053715_ChIP-Seq_YYC3_Human0.86119850
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85645473
130* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84755356
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84360167
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.84339179
133* TET1_21451524_ChIP-Seq_MESCs_Mouse0.83696101
134BCOR_27268052_Chip-Seq_Bcells_Human0.82977207
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82850678
136CTCF_21964334_Chip-Seq_Bcells_Human0.82822978
137GABP_19822575_ChIP-Seq_HepG2_Human0.82811014
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82759838
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.82685704
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82506642
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82226304
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82138837
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81745732
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81539592
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81388367
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.81249922
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80175473
148P68_20966046_ChIP-Seq_HELA_Human0.79385476
149GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77931288
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77762838
151RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76955238
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75776020
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.75610641
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.75469286
155* XRN2_22483619_ChIP-Seq_HELA_Human0.74718287
156ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74018494
157* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73805560
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72916429
159SPI1_20517297_ChIP-Seq_HL60_Human0.72682980
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71407816
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70167244
162CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70160080
163NANOG_18555785_ChIP-Seq_MESCs_Mouse0.69517088
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.68996499
165* YY1_22570637_ChIP-Seq_MALME-3M_Human0.68720910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.47233168
2MP0003646_muscle_fatigue4.39615986
3MP0005360_urolithiasis4.38921818
4MP0002837_dystrophic_cardiac_calcinosis4.30501738
5MP0003806_abnormal_nucleotide_metabolis3.68316075
6MP0005085_abnormal_gallbladder_physiolo3.51067664
7MP0003136_yellow_coat_color3.50715344
8MP0004084_abnormal_cardiac_muscle3.26820129
9MP0005365_abnormal_bile_salt3.22622418
10MP0000751_myopathy2.85677824
11MP0006036_abnormal_mitochondrial_physio2.84387431
12MP0005330_cardiomyopathy2.79996552
13MP0004130_abnormal_muscle_cell2.73721364
14MP0000749_muscle_degeneration2.70299693
15MP0004215_abnormal_myocardial_fiber2.68453412
16MP0004036_abnormal_muscle_relaxation2.57920478
17MP0008875_abnormal_xenobiotic_pharmacok2.56630320
18MP0005332_abnormal_amino_acid2.46749551
19MP0003195_calcinosis2.35790882
20MP0009840_abnormal_foam_cell2.20934075
21MP0005670_abnormal_white_adipose2.18335964
22MP0003252_abnormal_bile_duct2.11590259
23MP0010329_abnormal_lipoprotein_level2.08594776
24MP0002653_abnormal_ependyma_morphology2.03765264
25MP0004087_abnormal_muscle_fiber2.02816129
26MP0005666_abnormal_adipose_tissue2.00658237
27MP0002972_abnormal_cardiac_muscle1.90659710
28MP0002269_muscular_atrophy1.87912141
29MP0008775_abnormal_heart_ventricle1.87658247
30MP0003221_abnormal_cardiomyocyte_apopto1.86924692
31MP0000750_abnormal_muscle_regeneration1.79124879
32MP0004043_abnormal_pH_regulation1.76363932
33MP0005319_abnormal_enzyme/_coenzyme1.74769893
34MP0002638_abnormal_pupillary_reflex1.74289298
35MP0005385_cardiovascular_system_phenoty1.74189144
36MP0001544_abnormal_cardiovascular_syste1.74189144
37MP0005083_abnormal_biliary_tract1.73063192
38MP0010030_abnormal_orbit_morphology1.72917272
39MP0009379_abnormal_foot_pigmentation1.71680787
40MP0003186_abnormal_redox_activity1.71187379
41MP0005620_abnormal_muscle_contractility1.67696982
42MP0000566_synostosis1.61954229
43MP0010630_abnormal_cardiac_muscle1.60231725
44MP0006035_abnormal_mitochondrial_morpho1.58542491
45MP0002118_abnormal_lipid_homeostasis1.57611164
46MP0001346_abnormal_lacrimal_gland1.56506882
47MP0003137_abnormal_impulse_conducting1.55793739
48MP0005584_abnormal_enzyme/coenzyme_acti1.52029067
49MP0006138_congestive_heart_failure1.51600167
50MP0000747_muscle_weakness1.51478635
51MP0009643_abnormal_urine_homeostasis1.49897543
52MP0002106_abnormal_muscle_physiology1.47805310
53MP0001666_abnormal_nutrient_absorption1.43573350
54MP0002876_abnormal_thyroid_physiology1.42672073
55MP0000609_abnormal_liver_physiology1.41118056
56MP0002938_white_spotting1.40244179
57MP0003191_abnormal_cellular_cholesterol1.39250531
58MP0004233_abnormal_muscle_weight1.36815924
59MP0004185_abnormal_adipocyte_glucose1.36370894
60MP0002249_abnormal_larynx_morphology1.29221216
61MP0002971_abnormal_brown_adipose1.29122999
62MP0003705_abnormal_hypodermis_morpholog1.28856139
63MP0005266_abnormal_metabolism1.27642165
64MP0000759_abnormal_skeletal_muscle1.26797307
65MP0004019_abnormal_vitamin_homeostasis1.26083906
66MP0002332_abnormal_exercise_endurance1.25579417
67MP0004484_altered_response_of1.21644665
68MP0002064_seizures1.20249602
69MP0005375_adipose_tissue_phenotype1.20031032
70MP0004858_abnormal_nervous_system1.15571037
71MP0005369_muscle_phenotype1.15507317
72MP0003283_abnormal_digestive_organ1.13562021
73MP0009745_abnormal_behavioral_response1.12044346
74MP0001485_abnormal_pinna_reflex1.11091531
75MP0009046_muscle_twitch1.09305682
76MP0000343_altered_response_to1.06649379
77MP0001764_abnormal_homeostasis1.06406598
78MP0002078_abnormal_glucose_homeostasis1.02374341
79MP0002138_abnormal_hepatobiliary_system1.02081460
80MP0003828_pulmonary_edema1.01934147
81MP0004145_abnormal_muscle_electrophysio1.01377918
82MP0003315_abnormal_perineum_morphology0.99892582
83MP0003890_abnormal_embryonic-extraembry0.99334544
84MP0005451_abnormal_body_composition0.99316293
85MP0003656_abnormal_erythrocyte_physiolo0.98446599
86MP0003959_abnormal_lean_body0.97209964
87MP0002108_abnormal_muscle_morphology0.96698438
88MP0010368_abnormal_lymphatic_system0.96152299
89MP0004142_abnormal_muscle_tone0.93617036
90MP0009780_abnormal_chondrocyte_physiolo0.92516538
91MP0001756_abnormal_urination0.91938598
92MP0005636_abnormal_mineral_homeostasis0.91671609
93MP0009384_cardiac_valve_regurgitation0.91031535
94MP0004085_abnormal_heartbeat0.90676397
95MP0004885_abnormal_endolymph0.90377563
96MP0000534_abnormal_ureter_morphology0.87571098
97MP0000598_abnormal_liver_morphology0.87215337
98MP0004147_increased_porphyrin_level0.87116920
99MP0005165_increased_susceptibility_to0.86394619
100MP0000230_abnormal_systemic_arterial0.86097466
101MP0005535_abnormal_body_temperature0.84347457
102MP0004133_heterotaxia0.82545559
103MP0000579_abnormal_nail_morphology0.81384600
104MP0002127_abnormal_cardiovascular_syste0.81285885
105MP0004270_analgesia0.81182883
106MP0003950_abnormal_plasma_membrane0.79758982
107MP0005187_abnormal_penis_morphology0.78833462
108MP0003879_abnormal_hair_cell0.78697915
109MP0008961_abnormal_basal_metabolism0.78548694
110MP0005376_homeostasis/metabolism_phenot0.77621467
111MP0005058_abnormal_lysosome_morphology0.77321040
112MP0009053_abnormal_anal_canal0.77087018
113MP0005334_abnormal_fat_pad0.75417215
114MP0000762_abnormal_tongue_morphology0.74592634
115MP0002160_abnormal_reproductive_system0.74419415
116MP0003632_abnormal_nervous_system0.72926521
117MP0003567_abnormal_fetal_cardiomyocyte0.72111881
118MP0003942_abnormal_urinary_system0.70739890
119MP0000631_abnormal_neuroendocrine_gland0.70426246
120MP0002970_abnormal_white_adipose0.69546315
121MP0005171_absent_coat_pigmentation0.69539678
122MP0009642_abnormal_blood_homeostasis0.69343155
123MP0004742_abnormal_vestibular_system0.68657874
124MP0002067_abnormal_sensory_capabilities0.68480077
125MP0009115_abnormal_fat_cell0.67629425
126MP0000733_abnormal_muscle_development0.65341910
127MP0005551_abnormal_eye_electrophysiolog0.65277024
128MP0002089_abnormal_postnatal_growth/wei0.65093986
129MP0000266_abnormal_heart_morphology0.64802410
130MP0000026_abnormal_inner_ear0.64467593
131MP0005503_abnormal_tendon_morphology0.64385032
132MP0003638_abnormal_response/metabolism_0.64009616
133MP0008569_lethality_at_weaning0.63851961
134MP0003011_delayed_dark_adaptation0.63528781
135MP0002272_abnormal_nervous_system0.62152297
136MP0002572_abnormal_emotion/affect_behav0.61993511
137MP0000013_abnormal_adipose_tissue0.60709914
138MP0009763_increased_sensitivity_to0.58900311
139MP0003279_aneurysm0.58002494
140MP0000003_abnormal_adipose_tissue0.57672462
141MP0003566_abnormal_cell_adhesion0.55808188
142MP0008469_abnormal_protein_level0.55380095
143MP0000358_abnormal_cell_content/0.54905694
144MP0009697_abnormal_copulation0.54686653
145MP0001765_abnormal_ion_homeostasis0.54241484
146MP0006054_spinal_hemorrhage0.54064071
147MP0001661_extended_life_span0.53578629
148MP0008438_abnormal_cutaneous_collagen0.52606771
149MP0002136_abnormal_kidney_physiology0.49152872
150MP0002128_abnormal_blood_circulation0.48951314

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.75609124
2Hypoglycemic coma (HP:0001325)4.71036596
3Muscle fiber inclusion bodies (HP:0100299)4.62271656
4Nemaline bodies (HP:0003798)4.46806518
5Abnormality of fatty-acid metabolism (HP:0004359)4.40405218
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.39661561
7Hepatic necrosis (HP:0002605)4.34021572
8Ketoacidosis (HP:0001993)4.26223582
9Hyperglycinuria (HP:0003108)4.19873275
10Sudden death (HP:0001699)4.17302580
11Ketosis (HP:0001946)4.14150966
12Hyperammonemia (HP:0001987)4.12227849
13Dicarboxylic aciduria (HP:0003215)4.10389215
14Abnormality of dicarboxylic acid metabolism (HP:0010995)4.10389215
15Rhabdomyolysis (HP:0003201)3.97212720
16Exercise-induced myalgia (HP:0003738)3.95039720
17Acute encephalopathy (HP:0006846)3.94585307
18Exercise-induced muscle cramps (HP:0003710)3.94026751
19Cerebral edema (HP:0002181)3.92368663
20Abnormal mitochondria in muscle tissue (HP:0008316)3.89126853
21Ventricular tachycardia (HP:0004756)3.77719325
22Generalized aminoaciduria (HP:0002909)3.72886097
23Acute necrotizing encephalopathy (HP:0006965)3.70462224
24Abnormality of glycine metabolism (HP:0010895)3.68670692
25Abnormality of serine family amino acid metabolism (HP:0010894)3.68670692
26Hepatocellular necrosis (HP:0001404)3.53163437
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.45555226
28Type 1 muscle fiber predominance (HP:0003803)3.45291087
29Abnormality of cells of the erythroid lineage (HP:0012130)3.42453092
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41208032
31Abnormal number of erythroid precursors (HP:0012131)3.31228683
32Calf muscle hypertrophy (HP:0008981)3.30396354
33Increased muscle lipid content (HP:0009058)3.30037971
34Large for gestational age (HP:0001520)3.28900645
35Xanthomatosis (HP:0000991)3.21225981
36Hyperglycinemia (HP:0002154)3.19235885
37Lethargy (HP:0001254)3.17056476
38Birth length less than 3rd percentile (HP:0003561)3.16580864
39Nausea (HP:0002018)3.16213863
40* Palpitations (HP:0001962)3.16066520
41Lipoatrophy (HP:0100578)3.11775327
42Mitochondrial inheritance (HP:0001427)3.10350186
43Lactic acidosis (HP:0003128)3.09591706
44Increased CSF lactate (HP:0002490)3.08619629
45Ragged-red muscle fibers (HP:0003200)3.01702064
46Right ventricular cardiomyopathy (HP:0011663)3.01177998
47Muscle hypertrophy of the lower extremities (HP:0008968)3.00803072
48Proximal tubulopathy (HP:0000114)2.98888101
49Progressive macrocephaly (HP:0004481)2.98341284
50Muscle fiber splitting (HP:0003555)2.97923675
51Intrahepatic cholestasis (HP:0001406)2.96902899
52Metabolic acidosis (HP:0001942)2.96049350
53Increased serum pyruvate (HP:0003542)2.93656007
54Abnormality of glycolysis (HP:0004366)2.93656007
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92567797
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92567797
57Dilated cardiomyopathy (HP:0001644)2.90614992
58Asymmetric septal hypertrophy (HP:0001670)2.86184270
59Increased intramyocellular lipid droplets (HP:0012240)2.76905571
60Myopathic facies (HP:0002058)2.73840403
61Hypoalphalipoproteinemia (HP:0003233)2.72089911
62Atrial fibrillation (HP:0005110)2.71704736
63Vomiting (HP:0002013)2.70667485
64Hyperlipoproteinemia (HP:0010980)2.70210020
65Abnormality of serum amino acid levels (HP:0003112)2.69305485
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67791615
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65736850
68Respiratory failure (HP:0002878)2.65695741
69Abnormality of the calf musculature (HP:0001430)2.61882428
70Deep venous thrombosis (HP:0002625)2.61846969
71Gout (HP:0001997)2.60969529
72Abnormality of alanine metabolism (HP:0010916)2.56557632
73Hyperalaninemia (HP:0003348)2.56557632
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56557632
75Hypolipoproteinemia (HP:0010981)2.56073206
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55351255
77Hyporeflexia of lower limbs (HP:0002600)2.54813032
78Hypobetalipoproteinemia (HP:0003563)2.54159435
79Primary atrial arrhythmia (HP:0001692)2.49620433
80Exercise intolerance (HP:0003546)2.48706455
81Limb-girdle muscle atrophy (HP:0003797)2.48312458
82Supraventricular tachycardia (HP:0004755)2.47049913
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46092713
84Supraventricular arrhythmia (HP:0005115)2.41837658
85EMG: myopathic abnormalities (HP:0003458)2.41826933
86Abnormality of urine glucose concentration (HP:0011016)2.40909475
87Glycosuria (HP:0003076)2.40909475
88Increased serum lactate (HP:0002151)2.39612533
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37230691
90Late onset (HP:0003584)2.36675671
91Subaortic stenosis (HP:0001682)2.34053372
92Abnormality of the left ventricular outflow tract (HP:0011103)2.34053372
93Muscle stiffness (HP:0003552)2.32642570
94Increased connective tissue (HP:0009025)2.31947341
95Methylmalonic aciduria (HP:0012120)2.31699755
96Congenital, generalized hypertrichosis (HP:0004540)2.31322333
97Abnormality of purine metabolism (HP:0004352)2.30552488
98Delayed CNS myelination (HP:0002188)2.30369024
99Syncope (HP:0001279)2.29366732
100Lipid accumulation in hepatocytes (HP:0006561)2.27553273
101Rimmed vacuoles (HP:0003805)2.25771849
102Type II lissencephaly (HP:0007260)2.24895142
103Multiple enchondromatosis (HP:0005701)2.24534673
104Hyperinsulinemic hypoglycemia (HP:0000825)2.22568462
105Macrocytic anemia (HP:0001972)2.21422605
106Atrioventricular block (HP:0001678)2.20937885
107Concave nail (HP:0001598)2.19588976
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18370239
109Hyperuricemia (HP:0002149)2.16863826
110Increased purine levels (HP:0004368)2.16863826
111CNS demyelination (HP:0007305)2.16329551
112Ventricular arrhythmia (HP:0004308)2.15692531
113Cholelithiasis (HP:0001081)2.10677033
114Heart block (HP:0012722)2.10510699
115Renal cortical cysts (HP:0000803)2.09073952
116Bundle branch block (HP:0011710)2.06012416
117Metabolic alkalosis (HP:0200114)2.04773185
118Breast hypoplasia (HP:0003187)2.01472821
119Skin nodule (HP:0200036)2.01052280
120Abnormal atrioventricular conduction (HP:0005150)1.98187587
121Hypoplastic ischia (HP:0003175)1.97181182
122Centrally nucleated skeletal muscle fibers (HP:0003687)1.96036550
123Alkalosis (HP:0001948)1.94585237
124Distal lower limb muscle weakness (HP:0009053)1.93864365
125Generalized muscle weakness (HP:0003324)1.92866698
126Partial agenesis of the corpus callosum (HP:0001338)1.91807898
127Myotonia (HP:0002486)1.85804721
128Hyperacusis (HP:0010780)1.85082608
129Dysmetric saccades (HP:0000641)1.84299912
130Neck muscle weakness (HP:0000467)1.81636277
131Frequent falls (HP:0002359)1.80201660
132Distal arthrogryposis (HP:0005684)1.78708581
133Progressive muscle weakness (HP:0003323)1.78570007
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.77635242
135Ulnar deviation of the wrist (HP:0003049)1.76748430
136Decreased subcutaneous fat (HP:0001002)1.74339527
137Severe muscular hypotonia (HP:0006829)1.74227258
138Hyperkalemia (HP:0002153)1.72895492
139Hypoplasia of the pons (HP:0012110)1.72842737
140Reduced antithrombin III activity (HP:0001976)1.72694248
141Broad metatarsal (HP:0001783)1.71515780
142Tubular atrophy (HP:0000092)1.71399917
143Calcaneovalgus deformity (HP:0001848)1.70729617
144Prolonged partial thromboplastin time (HP:0003645)1.70661014
145Posterior embryotoxon (HP:0000627)1.70169585
146Abnormality of the pons (HP:0007361)1.70052096
147Back pain (HP:0003418)1.68891836
148Prominent supraorbital ridges (HP:0000336)1.68698941
149Abnormality of the diencephalon (HP:0010662)1.68476859
150Abnormality of the ischium (HP:0003174)1.66695164
151Hyperaldosteronism (HP:0000859)1.65022283
152Hypokalemia (HP:0002900)1.64139902
153Abnormality of the vitreous humor (HP:0004327)1.62547638
154Confusion (HP:0001289)1.59699170
155Patellar aplasia (HP:0006443)1.59587975
156Spastic tetraparesis (HP:0001285)1.59327826
157Reticulocytopenia (HP:0001896)1.59115731
158Abnormality of potassium homeostasis (HP:0011042)1.58029679
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.57125790
160Absent/shortened dynein arms (HP:0200106)1.57125790
161Clumsiness (HP:0002312)1.56559075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.22097524
2TRIB34.01263590
3PNCK3.94327401
4TTN3.65843392
5PDK33.40670659
6PDK43.40670659
7PKN23.20547249
8OBSCN3.07852471
9MAPK153.03419323
10MYLK2.86934892
11NEK12.83033389
12PHKG22.61560409
13PHKG12.61560409
14NME22.56656582
15LMTK22.48505870
16ERN12.26934234
17ICK2.23621690
18ACVR1B2.14449571
19FLT32.05714539
20EEF2K2.02254184
21VRK21.91827912
22PDK21.91389892
23MAP3K91.90433152
24PINK11.88298610
25ADRBK21.86155201
26BMPR1B1.78179331
27WNK41.72349655
28KSR21.71298576
29WEE11.60925461
30TIE11.51634306
31LATS11.47262022
32PIK3CA1.40830412
33NEK91.40819306
34MAP2K31.39594228
35CDK121.39243948
36KDR1.35180398
37STK38L1.33045700
38CAMK1D1.32130566
39ILK1.30183988
40STK241.29873970
41SIK11.28601270
42NTRK11.24167425
43DAPK21.23978532
44MUSK1.18942847
45EPHA21.17368892
46MAP3K101.16583895
47DMPK1.16566340
48LRRK21.10231398
49MAPKAPK51.09834318
50NTRK31.07638012
51MARK11.07329206
52ARAF1.07230159
53MAPKAPK31.06898957
54MAP3K111.04663651
55RPS6KB21.03145043
56FGFR41.02878302
57NEK20.95651553
58OXSR10.94883395
59CAMK1G0.94851004
60MAP3K30.92933551
61DAPK30.91535644
62MAPK110.87373786
63MAP3K50.84465670
64PRKAA20.82877176
65PIK3CG0.82656925
66LIMK10.81941372
67PTK60.81624740
68PAK20.81494222
69MAP3K20.77991603
70CAMKK20.76399651
71EIF2AK10.75230364
72PRKAA10.70510333
73MAP3K70.70191501
74PRKD10.68831721
75INSRR0.68562069
76NME10.65626677
77ADRBK10.65136534
78MAPK120.63936395
79STK40.63323271
80CAMK2D0.62933250
81ABL20.61804697
82PDGFRA0.61770773
83TESK10.61031928
84RIPK10.60010342
85PAK30.59868683
86MST1R0.59823387
87TRPM70.59170548
88PIM20.58981491
89CDK30.56643315
90SIK20.56284532
91WNK10.55017890
92CAMK10.54361786
93CAMK2G0.52265126
94TAOK20.51851543
95TGFBR20.51174830
96TESK20.51108680
97PRKG20.50922455
98PAK40.49906786
99ROCK10.48841956
100MAP3K130.48370779
101TBK10.48311949
102WNK30.48000830
103LATS20.47379258
104CAMK2A0.45751604
105MTOR0.45651625
106VRK10.45453708
107TLK10.45225797
108CAMK2B0.43332232
109PRKACG0.43311746
110YES10.43276599
111PRKCG0.42671083
112MET0.40721611
113TTK0.40327967
114TYRO30.40051556
115CDK40.39521443
116CDC42BPA0.39311518
117STK390.39030808
118AKT20.38515410
119MAP3K80.38086998
120MAP2K60.37983002
121BUB10.36565210
122DYRK30.36019235
123DYRK1B0.34837393
124CAMK40.34189162
125EPHB20.34157140
126CAMKK10.33217993
127PTK20.33095219
128ERBB40.32783995
129CDK70.32697879
130ZAK0.32324898
131SMG10.32268674
132CSNK1E0.32119199
133STK100.31482688
134BRAF0.30220406
135PDPK10.30200122
136STK160.29390230
137MAP2K10.28358103
138PBK0.26862289
139GRK70.26511522
140RPS6KC10.26368664
141RPS6KL10.26368664
142TGFBR10.25977216
143BRSK20.25933408
144GRK10.25905960
145STK380.25900086
146MAPK40.25329144
147CHEK20.25180402
148RPS6KA30.24316314
149GSK3A0.22424579
150RPS6KA40.21783688
151MAP2K40.21210609
152RPS6KA60.20728120
153JAK20.19811304
154RPS6KA10.18710659
155PRKACA0.18409389
156MAP2K20.18134851
157PRKACB0.17196854

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.48312633
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83835933
3Propanoate metabolism_Homo sapiens_hsa006403.52780151
4Fatty acid degradation_Homo sapiens_hsa000713.36620219
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.20547503
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.12314288
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01070914
8Fatty acid metabolism_Homo sapiens_hsa012122.51848614
9* Carbon metabolism_Homo sapiens_hsa012002.50034686
10Pyruvate metabolism_Homo sapiens_hsa006202.41240477
11Butanoate metabolism_Homo sapiens_hsa006502.20673620
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.12922790
13* Oxidative phosphorylation_Homo sapiens_hsa001902.12922138
14Parkinsons disease_Homo sapiens_hsa050122.10531766
15Tryptophan metabolism_Homo sapiens_hsa003802.07876427
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05539884
17Arginine biosynthesis_Homo sapiens_hsa002202.01499333
18Nitrogen metabolism_Homo sapiens_hsa009101.94042936
19Peroxisome_Homo sapiens_hsa041461.91140812
20PPAR signaling pathway_Homo sapiens_hsa033201.87548897
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80730905
22Biosynthesis of amino acids_Homo sapiens_hsa012301.72238251
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68903925
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66031776
25beta-Alanine metabolism_Homo sapiens_hsa004101.65433963
26Fatty acid elongation_Homo sapiens_hsa000621.62753312
27* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56701858
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55849621
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55508876
30Cardiac muscle contraction_Homo sapiens_hsa042601.52877429
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45795456
32Sulfur metabolism_Homo sapiens_hsa009201.43103516
33Alzheimers disease_Homo sapiens_hsa050101.33351234
34Starch and sucrose metabolism_Homo sapiens_hsa005001.31834631
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31030963
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.22592566
37Huntingtons disease_Homo sapiens_hsa050161.22205685
38Selenocompound metabolism_Homo sapiens_hsa004501.20694042
39Sulfur relay system_Homo sapiens_hsa041221.18377096
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15262012
41Phenylalanine metabolism_Homo sapiens_hsa003601.10387923
42Folate biosynthesis_Homo sapiens_hsa007901.09887002
43Arginine and proline metabolism_Homo sapiens_hsa003301.08778889
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03362975
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98555304
46Fat digestion and absorption_Homo sapiens_hsa049750.97732526
47Complement and coagulation cascades_Homo sapiens_hsa046100.97236505
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.95449116
49Pentose phosphate pathway_Homo sapiens_hsa000300.93732085
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91070798
51Chemical carcinogenesis_Homo sapiens_hsa052040.90165572
52Tyrosine metabolism_Homo sapiens_hsa003500.90140824
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90034623
54Caffeine metabolism_Homo sapiens_hsa002320.89959210
55Histidine metabolism_Homo sapiens_hsa003400.88944739
56Circadian rhythm_Homo sapiens_hsa047100.88826054
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84542505
58Glutathione metabolism_Homo sapiens_hsa004800.84409575
59Galactose metabolism_Homo sapiens_hsa000520.80890678
60Phototransduction_Homo sapiens_hsa047440.79612045
61Bile secretion_Homo sapiens_hsa049760.75965661
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75941164
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75500472
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.72712415
65Lysine degradation_Homo sapiens_hsa003100.70380673
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70107843
67Fructose and mannose metabolism_Homo sapiens_hsa000510.69433170
68* Metabolic pathways_Homo sapiens_hsa011000.69279995
69Retinol metabolism_Homo sapiens_hsa008300.68705810
70Bladder cancer_Homo sapiens_hsa052190.68563858
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68536938
72Mineral absorption_Homo sapiens_hsa049780.67168499
73Dilated cardiomyopathy_Homo sapiens_hsa054140.63550804
74Fatty acid biosynthesis_Homo sapiens_hsa000610.62140283
75Glycerolipid metabolism_Homo sapiens_hsa005610.59787655
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.56032943
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.55925878
78Prion diseases_Homo sapiens_hsa050200.55366800
79Insulin secretion_Homo sapiens_hsa049110.53680481
80One carbon pool by folate_Homo sapiens_hsa006700.51555189
81Insulin resistance_Homo sapiens_hsa049310.51138331
82Calcium signaling pathway_Homo sapiens_hsa040200.49725030
83Nucleotide excision repair_Homo sapiens_hsa034200.45403103
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.43437513
85Glucagon signaling pathway_Homo sapiens_hsa049220.42299035
86Cocaine addiction_Homo sapiens_hsa050300.42016647
87Proteasome_Homo sapiens_hsa030500.41172965
88ABC transporters_Homo sapiens_hsa020100.40551276
89Ovarian steroidogenesis_Homo sapiens_hsa049130.38518584
90AMPK signaling pathway_Homo sapiens_hsa041520.37495638
91Vitamin digestion and absorption_Homo sapiens_hsa049770.36132844
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35910720
93Purine metabolism_Homo sapiens_hsa002300.35427713
94Staphylococcus aureus infection_Homo sapiens_hsa051500.35302260
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34926017
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33359796
97Gastric acid secretion_Homo sapiens_hsa049710.32893645
98Homologous recombination_Homo sapiens_hsa034400.32866252
99Nicotine addiction_Homo sapiens_hsa050330.32590383
100RNA polymerase_Homo sapiens_hsa030200.32574638
101Insulin signaling pathway_Homo sapiens_hsa049100.31696364
102Thyroid hormone synthesis_Homo sapiens_hsa049180.29903562
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28578978
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27804179
105Ribosome_Homo sapiens_hsa030100.23729787
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19814899
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18380892
108Viral myocarditis_Homo sapiens_hsa054160.16595715
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.12667196
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11919733
111Pyrimidine metabolism_Homo sapiens_hsa002400.08231323
112Vitamin B6 metabolism_Homo sapiens_hsa007500.03409528
113Linoleic acid metabolism_Homo sapiens_hsa005910.02586562
114Arachidonic acid metabolism_Homo sapiens_hsa005900.00143652
115Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0538852
116HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0519134
117Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0479295
118Renin-angiotensin system_Homo sapiens_hsa04614-0.0359492
119Protein export_Homo sapiens_hsa03060-0.0239713
120Other glycan degradation_Homo sapiens_hsa00511-0.0187994
121Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0005286

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