SDHAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.44999363
2protein neddylation (GO:0045116)5.08268034
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.77643424
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58906502
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.43506114
6ribosomal small subunit assembly (GO:0000028)4.38651103
7ATP synthesis coupled proton transport (GO:0015986)4.17053949
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17053949
9rRNA modification (GO:0000154)3.94885105
10cellular response to zinc ion (GO:0071294)3.80439394
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.78308723
12antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.75396185
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75310130
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74885585
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68905830
16sequestering of actin monomers (GO:0042989)3.64575805
17rRNA methylation (GO:0031167)3.61842543
18DNA deamination (GO:0045006)3.60714638
19* respiratory electron transport chain (GO:0022904)3.60664184
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55433572
21* electron transport chain (GO:0022900)3.50382845
22protein deneddylation (GO:0000338)3.45854960
23proteasome assembly (GO:0043248)3.42715016
24protein complex biogenesis (GO:0070271)3.42577105
25cullin deneddylation (GO:0010388)3.42347575
26viral transcription (GO:0019083)3.37738159
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36232012
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.36232012
29NADH dehydrogenase complex assembly (GO:0010257)3.36232012
30regulation of cellular amino acid metabolic process (GO:0006521)3.34561659
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33570120
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32189932
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29795234
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29795234
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.29264601
36translational termination (GO:0006415)3.27736716
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23751879
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23751879
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23751879
40mitochondrial respiratory chain complex assembly (GO:0033108)3.22655944
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21187324
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20773517
43protein localization to mitochondrion (GO:0070585)3.20591815
44platelet dense granule organization (GO:0060155)3.19711022
45oxidative phosphorylation (GO:0006119)3.18677065
46cotranslational protein targeting to membrane (GO:0006613)3.17912594
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17610536
48negative regulation of ligase activity (GO:0051352)3.17480497
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17480497
50metallo-sulfur cluster assembly (GO:0031163)3.15830399
51iron-sulfur cluster assembly (GO:0016226)3.15830399
52DNA catabolic process, exonucleolytic (GO:0000738)3.13589567
53polyketide metabolic process (GO:0030638)3.12610038
54doxorubicin metabolic process (GO:0044598)3.12610038
55daunorubicin metabolic process (GO:0044597)3.12610038
56protein targeting to ER (GO:0045047)3.12492408
57translational elongation (GO:0006414)3.06643451
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.06391009
59signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06391009
60ribosomal small subunit biogenesis (GO:0042274)3.03694204
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03602703
62respiratory chain complex IV assembly (GO:0008535)3.02754033
63antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.01095083
64signal transduction involved in cell cycle checkpoint (GO:0072395)2.99879067
65protein localization to endoplasmic reticulum (GO:0070972)2.99761991
66cellular response to interferon-beta (GO:0035458)2.98756779
67pseudouridine synthesis (GO:0001522)2.95707059
68base-excision repair, AP site formation (GO:0006285)2.95348226
69establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94253442
70neutrophil activation involved in immune response (GO:0002283)2.92562868
71cytochrome complex assembly (GO:0017004)2.91548492
72telomere maintenance via semi-conservative replication (GO:0032201)2.90476046
73response to interferon-beta (GO:0035456)2.89142153
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85845849
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85845849
76water-soluble vitamin biosynthetic process (GO:0042364)2.85674795
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84019844
78purine nucleotide salvage (GO:0032261)2.81710824
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81534192
80antigen processing and presentation of endogenous antigen (GO:0019883)2.80538582
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80098777
82inner mitochondrial membrane organization (GO:0007007)2.80068049
83regulation of B cell receptor signaling pathway (GO:0050855)2.79970643
84mannosylation (GO:0097502)2.79230136
85translation (GO:0006412)2.78548287
86protein targeting to mitochondrion (GO:0006626)2.78064017
87hydrogen ion transmembrane transport (GO:1902600)2.77712342
88heart contraction (GO:0060047)2.77675301
89heart process (GO:0003015)2.77675301
90signal peptide processing (GO:0006465)2.76516993
91autophagic vacuole fusion (GO:0000046)2.75988883
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75143817
93preassembly of GPI anchor in ER membrane (GO:0016254)2.74809647
94aerobic respiration (GO:0009060)2.74549028
95DNA double-strand break processing (GO:0000729)2.72245725
96establishment of protein localization to mitochondrion (GO:0072655)2.71990351
97deoxyribonucleotide catabolic process (GO:0009264)2.71250217
98organelle membrane fusion (GO:0090174)2.68560412
99GTP biosynthetic process (GO:0006183)2.68071066
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67142752
101defense response to protozoan (GO:0042832)2.66819019
102cellular component biogenesis (GO:0044085)2.66736704
103mitochondrial transport (GO:0006839)2.64916241
104termination of RNA polymerase III transcription (GO:0006386)2.64355462
105transcription elongation from RNA polymerase III promoter (GO:0006385)2.64355462
106positive regulation of ligase activity (GO:0051351)2.64124704
107regulation of B cell differentiation (GO:0045577)2.64061848
108regulation of cellular amine metabolic process (GO:0033238)2.63987360
109C-terminal protein lipidation (GO:0006501)2.63615887
110positive regulation of macrophage differentiation (GO:0045651)2.63445592
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.63443228
112cytidine catabolic process (GO:0006216)2.63270765
113cytidine deamination (GO:0009972)2.63270765
114cytidine metabolic process (GO:0046087)2.63270765
115tRNA processing (GO:0008033)2.63126607
116cellular protein complex disassembly (GO:0043624)2.63111233
117viral life cycle (GO:0019058)2.62895216
118proton transport (GO:0015992)2.62882352
119deoxyribose phosphate catabolic process (GO:0046386)2.62357053
120amino acid salvage (GO:0043102)2.62260950
121L-methionine salvage (GO:0071267)2.62260950
122L-methionine biosynthetic process (GO:0071265)2.62260950
123nucleoside salvage (GO:0043174)2.61492546
124regulation of mitochondrial translation (GO:0070129)2.61348060
125DNA strand elongation involved in DNA replication (GO:0006271)2.60962481
126positive regulation of cell cycle arrest (GO:0071158)2.60326093
127ribosomal large subunit biogenesis (GO:0042273)2.59899424
128pyrimidine nucleotide catabolic process (GO:0006244)2.59614340
129telomere maintenance via recombination (GO:0000722)2.59413680
130hydrogen transport (GO:0006818)2.58446418
131translational initiation (GO:0006413)2.58220807
132tricarboxylic acid cycle (GO:0006099)2.58059998
133intracellular protein transmembrane import (GO:0044743)2.58048585
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57848418
135regulation of alpha-beta T cell proliferation (GO:0046640)2.57560975
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57018725
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55754271
138deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.55584357
139purine-containing compound salvage (GO:0043101)2.55455517
140T cell migration (GO:0072678)2.55151843
141energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.54096270
142ATP hydrolysis coupled proton transport (GO:0015991)2.54096270
143ATP biosynthetic process (GO:0006754)2.51802601
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.51708018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.84484783
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83728004
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.81835908
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78401939
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.68797944
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57890058
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.33668279
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32391561
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12743186
10E2F7_22180533_ChIP-Seq_HELA_Human3.03169158
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.91668895
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.83054240
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82416650
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.77527388
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72607217
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.68281794
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54238952
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53247753
19VDR_23849224_ChIP-Seq_CD4+_Human2.52051199
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.51315555
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.47894708
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46112767
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29492639
24FOXP3_21729870_ChIP-Seq_TREG_Human2.19432428
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.13905351
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13768531
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10524738
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10487773
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06052056
30DCP1A_22483619_ChIP-Seq_HELA_Human2.05596444
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05170763
32ERG_20887958_ChIP-Seq_HPC-7_Mouse2.03975176
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96267488
34ELK1_19687146_ChIP-ChIP_HELA_Human1.95038774
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89010889
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86943683
37SPI1_23547873_ChIP-Seq_NB4_Human1.80872490
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79403548
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76141991
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75130261
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74983958
42GABP_19822575_ChIP-Seq_HepG2_Human1.72998756
43XRN2_22483619_ChIP-Seq_HELA_Human1.70385676
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65726123
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64624451
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64259667
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54041352
48* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49578153
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48655542
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45650735
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44124610
52VDR_22108803_ChIP-Seq_LS180_Human1.43160984
53GATA1_22025678_ChIP-Seq_K562_Human1.41624521
54CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.40862021
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38571510
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38352835
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37826188
58TTF2_22483619_ChIP-Seq_HELA_Human1.37767552
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36109265
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35277655
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.29594369
62MYB_26560356_Chip-Seq_TH2_Human1.29033806
63ZNF274_21170338_ChIP-Seq_K562_Hela1.27553380
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26105872
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.25852952
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.23931820
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23413717
68CIITA_25753668_ChIP-Seq_RAJI_Human1.23313582
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22961905
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.22681769
71IRF1_19129219_ChIP-ChIP_H3396_Human1.20962312
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18940447
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18373995
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.16845853
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13896401
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13185768
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11151118
78KDM5A_27292631_Chip-Seq_BREAST_Human1.10018609
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08355696
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08248661
81GATA3_26560356_Chip-Seq_TH2_Human1.06898793
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06563219
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05997969
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04874419
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04804277
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03580157
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03502622
88TFEB_21752829_ChIP-Seq_HELA_Human1.02343508
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01998689
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01839844
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01257815
92STAT1_20625510_ChIP-Seq_HELA_Human1.01029088
93MYB_26560356_Chip-Seq_TH1_Human1.00363222
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99803329
95SCL_19346495_ChIP-Seq_HPC-7_Human0.98760254
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97916640
97VDR_21846776_ChIP-Seq_THP-1_Human0.97383764
98TP53_22573176_ChIP-Seq_HFKS_Human0.96767391
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95800965
100MAF_26560356_Chip-Seq_TH1_Human0.94536745
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94246403
102MYC_18940864_ChIP-ChIP_HL60_Human0.93962062
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93888161
104RUNX1_22412390_ChIP-Seq_EML_Mouse0.93285286
105* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92959445
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92815893
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92561365
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92507102
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.92492872
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91622177
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91104422
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90540698
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89578341
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89079854
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88799315
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88615822
117ERG_20517297_ChIP-Seq_VCAP_Human0.88362876
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87146704
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85197138
120HTT_18923047_ChIP-ChIP_STHdh_Human0.83895976
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83756107
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83712557
123MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83706376
124AR_20517297_ChIP-Seq_VCAP_Human0.83412161
125NANOG_20526341_ChIP-Seq_ESCs_Human0.78927333
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78375976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.14781772
2MP0005671_abnormal_response_to3.62610847
3MP0009785_altered_susceptibility_to3.55615832
4MP0000685_abnormal_immune_system2.91960047
5MP0002148_abnormal_hypersensitivity_rea2.69607062
6MP0005000_abnormal_immune_tolerance2.61925281
7MP0001800_abnormal_humoral_immune2.46621336
8MP0003763_abnormal_thymus_physiology2.42379993
9MP0003436_decreased_susceptibility_to2.42014479
10MP0005025_abnormal_response_to2.41978786
11MP0005084_abnormal_gallbladder_morpholo2.40058725
12MP0006036_abnormal_mitochondrial_physio2.39590517
13MP0001790_abnormal_immune_system2.38827880
14MP0005387_immune_system_phenotype2.38827880
15MP0003646_muscle_fatigue2.29131628
16MP0002452_abnormal_antigen_presenting2.28684988
17MP0003724_increased_susceptibility_to2.26797613
18MP0002723_abnormal_immune_serum2.25217944
19MP0002420_abnormal_adaptive_immunity2.24125759
20MP0001819_abnormal_immune_cell2.21945141
21MP0003656_abnormal_erythrocyte_physiolo2.12858189
22MP0001853_heart_inflammation2.12625099
23MP0002398_abnormal_bone_marrow2.08152840
24MP0002837_dystrophic_cardiac_calcinosis2.05187412
25MP0003186_abnormal_redox_activity2.03032536
26MP0002419_abnormal_innate_immunity1.98352132
27MP0006082_CNS_inflammation1.93617911
28MP0002166_altered_tumor_susceptibility1.88153950
29MP0000716_abnormal_immune_system1.88015783
30MP0005075_abnormal_melanosome_morpholog1.87341776
31MP0000689_abnormal_spleen_morphology1.81394880
32MP0003786_premature_aging1.81058858
33MP0009333_abnormal_splenocyte_physiolog1.75067784
34MP0002722_abnormal_immune_system1.74868131
35MP0002163_abnormal_gland_morphology1.74716211
36MP0002405_respiratory_system_inflammati1.73606818
37MP0004147_increased_porphyrin_level1.73300468
38MP0002429_abnormal_blood_cell1.65463589
39MP0002102_abnormal_ear_morphology1.61264128
40MP0003011_delayed_dark_adaptation1.60853341
41MP0003806_abnormal_nucleotide_metabolis1.55615872
42MP0006035_abnormal_mitochondrial_morpho1.53965759
43MP0001529_abnormal_vocalization1.53626972
44MP0000343_altered_response_to1.53493448
45MP0008469_abnormal_protein_level1.53413844
46MP0008877_abnormal_DNA_methylation1.51621963
47MP0005310_abnormal_salivary_gland1.50108164
48MP0001845_abnormal_inflammatory_respons1.49987464
49MP0002396_abnormal_hematopoietic_system1.49007414
50MP0001984_abnormal_olfaction1.45471861
51MP0003693_abnormal_embryo_hatching1.45082665
52MP0009697_abnormal_copulation1.43730946
53MP0002277_abnormal_respiratory_mucosa1.39903636
54MP0004215_abnormal_myocardial_fiber1.35288574
55MP0001873_stomach_inflammation1.34599372
56MP0008872_abnormal_physiological_respon1.31920641
57MP0002006_tumorigenesis1.31812037
58MP0006054_spinal_hemorrhage1.30237916
59MP0005464_abnormal_platelet_physiology1.30069937
60MP0003866_abnormal_defecation1.29289776
61MP0010386_abnormal_urinary_bladder1.27068539
62MP0003718_maternal_effect1.26350298
63MP0000858_altered_metastatic_potential1.25040958
64MP0002132_abnormal_respiratory_system1.24632226
65MP0001348_abnormal_lacrimal_gland1.22729193
66MP0005379_endocrine/exocrine_gland_phen1.20992355
67MP0004957_abnormal_blastocyst_morpholog1.20089108
68MP0003123_paternal_imprinting1.20088583
69MP0005058_abnormal_lysosome_morphology1.19826770
70MP0000749_muscle_degeneration1.19810845
71MP0004133_heterotaxia1.19065402
72MP0004510_myositis1.18931218
73MP0005645_abnormal_hypothalamus_physiol1.18000122
74MP0000490_abnormal_crypts_of1.17755112
75MP0010155_abnormal_intestine_physiology1.16335571
76MP0002254_reproductive_system_inflammat1.15929568
77MP0010094_abnormal_chromosome_stability1.15517820
78MP0004142_abnormal_muscle_tone1.14743186
79MP0002653_abnormal_ependyma_morphology1.14252729
80MP0009765_abnormal_xenobiotic_induced1.14161356
81MP0008057_abnormal_DNA_replication1.13645064
82MP0003195_calcinosis1.13264190
83MP0001533_abnormal_skeleton_physiology1.12270373
84MP0004084_abnormal_cardiac_muscle1.12058047
85MP0008875_abnormal_xenobiotic_pharmacok1.11587864
86MP0009764_decreased_sensitivity_to1.10743699
87MP0001764_abnormal_homeostasis1.10695737
88MP0002933_joint_inflammation1.10277865
89MP0000703_abnormal_thymus_morphology1.09142203
90MP0008789_abnormal_olfactory_epithelium1.00852323
91MP0004036_abnormal_muscle_relaxation1.00803390
92MP0006072_abnormal_retinal_apoptosis1.00649259
93MP0009379_abnormal_foot_pigmentation0.98835882
94MP0003221_abnormal_cardiomyocyte_apopto0.98801173
95MP0003183_abnormal_peptide_metabolism0.98557760
96MP0005636_abnormal_mineral_homeostasis0.97595164
97MP0002693_abnormal_pancreas_physiology0.97084539
98MP0002019_abnormal_tumor_incidence0.96477674
99MP0000358_abnormal_cell_content/0.95660822
100MP0001919_abnormal_reproductive_system0.94742122
101MP0001905_abnormal_dopamine_level0.94714755
102MP0002095_abnormal_skin_pigmentation0.92657578
103MP0003077_abnormal_cell_cycle0.92033314
104MP0005410_abnormal_fertilization0.91792541
105MP0004808_abnormal_hematopoietic_stem0.90280568
106MP0005584_abnormal_enzyme/coenzyme_acti0.89570732
107MP0008007_abnormal_cellular_replicative0.89189077
108MP0009763_increased_sensitivity_to0.87140439
109MP0005397_hematopoietic_system_phenotyp0.86639688
110MP0001545_abnormal_hematopoietic_system0.86639688
111MP0005389_reproductive_system_phenotype0.83916329
112MP0003787_abnormal_imprinting0.83609135
113MP0001986_abnormal_taste_sensitivity0.83432627
114MP0002736_abnormal_nociception_after0.82240301
115MP0004947_skin_inflammation0.81408655
116MP0003303_peritoneal_inflammation0.80657387
117MP0008995_early_reproductive_senescence0.79356921
118MP0008004_abnormal_stomach_pH0.77385777
119MP0001756_abnormal_urination0.76528629
120MP0001663_abnormal_digestive_system0.76378278
121MP0003111_abnormal_nucleus_morphology0.75850732
122MP0008058_abnormal_DNA_repair0.75446611
123MP0000013_abnormal_adipose_tissue0.72234187
124MP0008775_abnormal_heart_ventricle0.71007328
125MP0000465_gastrointestinal_hemorrhage0.70389662
126MP0005174_abnormal_tail_pigmentation0.69504268
127MP0008932_abnormal_embryonic_tissue0.69282345
128MP0005319_abnormal_enzyme/_coenzyme0.68582269
129MP0000015_abnormal_ear_pigmentation0.66555815
130MP0002876_abnormal_thyroid_physiology0.65535941
131MP0005166_decreased_susceptibility_to0.64025946
132MP0008873_increased_physiological_sensi0.63223317
133MP0000372_irregular_coat_pigmentation0.62771472
134MP0005266_abnormal_metabolism0.62159188

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.15583377
2Abnormal mitochondria in muscle tissue (HP:0008316)5.05892927
3Mitochondrial inheritance (HP:0001427)4.61203752
4Hepatocellular necrosis (HP:0001404)4.37766790
5Progressive macrocephaly (HP:0004481)4.27154119
6Acute encephalopathy (HP:0006846)4.23806003
7Increased CSF lactate (HP:0002490)4.11234567
8Hepatic necrosis (HP:0002605)4.06594140
9Increased intramyocellular lipid droplets (HP:0012240)3.82744393
10Increased hepatocellular lipid droplets (HP:0006565)3.75060441
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74966879
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74966879
13Lipid accumulation in hepatocytes (HP:0006561)3.71370618
14Increased muscle lipid content (HP:0009058)3.65094762
15Exertional dyspnea (HP:0002875)3.64453551
16Exercise intolerance (HP:0003546)3.36225903
17Elevated erythrocyte sedimentation rate (HP:0003565)3.28802932
18Increased serum lactate (HP:0002151)3.23024235
19Cerebral edema (HP:0002181)3.21935429
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19503450
21Lactic acidosis (HP:0003128)3.17661922
22Stomatitis (HP:0010280)3.03843176
23Abnormal number of erythroid precursors (HP:0012131)3.00436994
24Recurrent abscess formation (HP:0002722)2.99505342
25Abnormality of cells of the erythroid lineage (HP:0012130)2.99407827
26Respiratory failure (HP:0002878)2.94165103
273-Methylglutaconic aciduria (HP:0003535)2.92994508
28Renal Fanconi syndrome (HP:0001994)2.92492596
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91509676
30Abnormality of alanine metabolism (HP:0010916)2.91509676
31Hyperalaninemia (HP:0003348)2.91509676
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88564101
33IgM deficiency (HP:0002850)2.80354200
34Recurrent bronchitis (HP:0002837)2.77335216
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.73243873
36Thrombocytosis (HP:0001894)2.72525906
37Vacuolated lymphocytes (HP:0001922)2.72158911
38Reduced antithrombin III activity (HP:0001976)2.67736116
39Gastrointestinal stroma tumor (HP:0100723)2.64634316
40Respiratory difficulties (HP:0002880)2.62604863
41Cerebral hemorrhage (HP:0001342)2.59504711
42Increased serum pyruvate (HP:0003542)2.58602509
43Abnormality of glycolysis (HP:0004366)2.58602509
44Agammaglobulinemia (HP:0004432)2.57907986
45Methylmalonic aciduria (HP:0012120)2.53428147
46Recurrent bacterial skin infections (HP:0005406)2.46073665
47* Neuroendocrine neoplasm (HP:0100634)2.45409984
48Pheochromocytoma (HP:0002666)2.45409984
49Esophageal neoplasm (HP:0100751)2.42439093
50Neoplasm of head and neck (HP:0012288)2.42439093
51Reticulocytopenia (HP:0001896)2.39174172
52Type I transferrin isoform profile (HP:0003642)2.38932172
53Chronic otitis media (HP:0000389)2.37287015
54Optic disc pallor (HP:0000543)2.35571638
55Abnormality of renal resorption (HP:0011038)2.32978634
56IgG deficiency (HP:0004315)2.29953509
57Petechiae (HP:0000967)2.26581473
58Decreased central vision (HP:0007663)2.25523247
59Severe combined immunodeficiency (HP:0004430)2.24654448
60Aplastic anemia (HP:0001915)2.24127654
61Autoimmune hemolytic anemia (HP:0001890)2.23223528
62Abnormality of urine glucose concentration (HP:0011016)2.21177381
63Glycosuria (HP:0003076)2.21177381
64Methylmalonic acidemia (HP:0002912)2.20831094
65Abnormality of midbrain morphology (HP:0002418)2.18293423
66Molar tooth sign on MRI (HP:0002419)2.18293423
67CNS demyelination (HP:0007305)2.17128305
68Vasculitis (HP:0002633)2.16924430
69Leukodystrophy (HP:0002415)2.16842798
70Abnormality of T cells (HP:0002843)2.15670148
71Palpitations (HP:0001962)2.14877656
72Gastrointestinal infarctions (HP:0005244)2.13946604
73Abnormality of T cell number (HP:0011839)2.12316999
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.10465924
75Lymphopenia (HP:0001888)2.09653507
76Neutropenia (HP:0001875)2.08933461
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08339785
78Generalized aminoaciduria (HP:0002909)2.08330570
79Progressive microcephaly (HP:0000253)2.07815473
80Abnormality of T cell physiology (HP:0011840)2.06785324
81Poor head control (HP:0002421)2.06309161
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06180176
83Chronic sinusitis (HP:0011109)2.06035226
84Pancytopenia (HP:0001876)2.05927603
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05295683
86Abnormal protein N-linked glycosylation (HP:0012347)2.05295683
87Abnormal protein glycosylation (HP:0012346)2.05295683
88Abnormal glycosylation (HP:0012345)2.05295683
89Increased IgM level (HP:0003496)2.04891923
90Recurrent viral infections (HP:0004429)2.03918347
91Microvesicular hepatic steatosis (HP:0001414)2.03596745
92Conjunctival hamartoma (HP:0100780)2.02187678
93Pallor (HP:0000980)2.01235783
94Emotional lability (HP:0000712)1.99350273
95Combined immunodeficiency (HP:0005387)1.98897393
96Birth length less than 3rd percentile (HP:0003561)1.98325255
97Fatigue (HP:0012378)1.96105415
98Renal cortical cysts (HP:0000803)1.95346633
99T lymphocytopenia (HP:0005403)1.90925426
100Rhabdomyolysis (HP:0003201)1.90459844
101Macrocytic anemia (HP:0001972)1.90281234
102Lethargy (HP:0001254)1.90036304
103Oral leukoplakia (HP:0002745)1.89844858
104Leukocytosis (HP:0001974)1.89129127
105Dicarboxylic aciduria (HP:0003215)1.89045449
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89045449
107B lymphocytopenia (HP:0010976)1.88791059
108Abnormality of B cell number (HP:0010975)1.88791059
109Granulocytopenia (HP:0001913)1.87821048
110Nausea (HP:0002018)1.87415437
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87402975
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86239191
113Hepatosplenomegaly (HP:0001433)1.85353831
114Type 2 muscle fiber atrophy (HP:0003554)1.84584478
115Eczematoid dermatitis (HP:0000976)1.83632650
116Abnormal rod and cone electroretinograms (HP:0008323)1.83079242
117Abnormality of the anterior horn cell (HP:0006802)1.82993413
118Degeneration of anterior horn cells (HP:0002398)1.82993413
119Recurrent fungal infections (HP:0002841)1.82856490
120Autoimmune thrombocytopenia (HP:0001973)1.82456111
121Purpura (HP:0000979)1.81849808
122Cerebral hypomyelination (HP:0006808)1.80806703
123Prolonged neonatal jaundice (HP:0006579)1.78447038
124Pancreatic cysts (HP:0001737)1.77536745
125Abnormality of macrophages (HP:0004311)1.77222021
126Abolished electroretinogram (ERG) (HP:0000550)1.77125598
127True hermaphroditism (HP:0010459)1.76576826
128Amaurosis fugax (HP:0100576)1.76484192
129Abnormality of serum amino acid levels (HP:0003112)1.73709031
130Pancreatic fibrosis (HP:0100732)1.73214149
131Abnormality of magnesium homeostasis (HP:0004921)1.70958022
132Abnormal pupillary function (HP:0007686)1.70641259
133Hypothermia (HP:0002045)1.70550161
134Hyperglycinemia (HP:0002154)1.68546918
135Hypomagnesemia (HP:0002917)1.66240601
136Medial flaring of the eyebrow (HP:0010747)1.66024878
137Congenital stationary night blindness (HP:0007642)1.64678847
138Muscle fiber atrophy (HP:0100295)1.64418688
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64162157
140Nephronophthisis (HP:0000090)1.62355622
141X-linked dominant inheritance (HP:0001423)1.60816254
142Abnormality of the labia minora (HP:0012880)1.60066509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.67971988
2STK163.47901376
3NME23.12879377
4PIM22.88819220
5MST42.84177670
6NUAK12.74878053
7EIF2AK12.69976152
8MAP3K122.66314231
9TBK12.41818902
10ARAF2.37647940
11TESK22.31896192
12PIK3CG2.25891360
13IRAK42.25740099
14EIF2AK32.19738014
15BUB12.18055317
16MAP4K12.14971733
17MAP3K142.13616311
18MAP4K22.12128157
19BLK1.91977888
20TAOK31.84510959
21IKBKE1.74984237
22KDR1.72501995
23SCYL21.72040947
24ACVR1B1.71219660
25BCKDK1.66040574
26KIT1.61059802
27TYK21.58849499
28TEC1.58188436
29TLK11.57526021
30ZAP701.56466482
31MAP3K131.53442054
32MYLK1.52691057
33TXK1.44056372
34TESK11.43532487
35BTK1.43402757
36SYK1.42722176
37CDK191.40294799
38RPS6KA41.32477272
39WEE11.30933710
40JAK31.28232883
41CDC71.26925725
42LIMK11.25264438
43WNK31.24820709
44IKBKB1.24672250
45MAPKAPK31.24364522
46BMPR1B1.24353060
47NME11.22427048
48VRK11.21164916
49GRK61.18563877
50PLK31.16280701
51TRIM281.15819958
52CAMKK21.09782791
53BRSK21.09331257
54LYN1.06294438
55PDK21.06193307
56ILK1.03554402
57NEK91.02572201
58DYRK21.01955325
59GRK10.98678128
60RAF10.93335690
61MARK30.92515863
62TNIK0.91050741
63CSNK1G30.90510402
64OBSCN0.90229875
65RIPK40.89249817
66MAP3K110.88996090
67LCK0.88878409
68ITK0.87592170
69CCNB10.86565529
70STK240.85797361
71FRK0.81939388
72LRRK20.81184503
73PDK40.79837141
74PDK30.79837141
75MUSK0.77989822
76PLK40.73874446
77PIM10.72795508
78PBK0.72518725
79CSNK1G20.71485427
80TAOK20.69781687
81ERN10.69741225
82PRKCQ0.68158621
83TSSK60.66953944
84CSNK1G10.66369934
85PLK10.65522312
86DYRK30.65286898
87MAP2K70.64999354
88WNK40.64072065
89DAPK30.63871632
90SRPK10.63386268
91ADRBK20.61391671
92OXSR10.61198929
93GRK70.58075613
94JAK10.57407318
95GRK50.56371344
96MAP2K30.56187527
97PLK20.55636788
98FLT30.55022422
99CDK80.54992087
100BRAF0.54814028
101DAPK10.54193255
102PASK0.52870409
103MAP2K60.52811619
104PHKG10.51543099
105PHKG20.51543099
106EIF2AK20.50356353
107BRSK10.48586411
108CSNK1A1L0.48353857
109IRAK30.47833600
110ADRBK10.47353271
111ABL20.45879326
112CSF1R0.45286572
113PRKCD0.45216529
114NEK10.45091807
115TGFBR10.43959472
116MATK0.43713387
117MAP2K20.43358368
118STK40.43268851
119MAP3K50.43040834
120FES0.40563209
121CSK0.40435242
122MAPK130.40421292
123PRKCI0.39227948
124ATR0.39136817
125TTN0.37670566
126MAPKAPK50.37201885
127RPS6KB20.35966364
128CSNK2A10.35697519
129MAPK120.34494394
130STK100.33803465
131TRPM70.33007065
132CSNK2A20.31476733
133RPS6KA50.30197953
134RPS6KA60.26246645
135ZAK0.25311149
136TNK20.24584563
137BMPR20.24582038

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.49045536
2Ribosome_Homo sapiens_hsa030103.78628797
3Oxidative phosphorylation_Homo sapiens_hsa001903.70847555
4Parkinsons disease_Homo sapiens_hsa050123.40864566
5DNA replication_Homo sapiens_hsa030302.77741200
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.59361943
7Protein export_Homo sapiens_hsa030602.50464979
8RNA polymerase_Homo sapiens_hsa030202.45785354
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37021736
10Alzheimers disease_Homo sapiens_hsa050102.27555594
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27147086
12Primary immunodeficiency_Homo sapiens_hsa053402.26249040
13Fatty acid elongation_Homo sapiens_hsa000622.22531965
14Huntingtons disease_Homo sapiens_hsa050162.22098982
15Mismatch repair_Homo sapiens_hsa034302.14114712
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08566315
17Allograft rejection_Homo sapiens_hsa053301.95632546
18Pyrimidine metabolism_Homo sapiens_hsa002401.95601680
19Graft-versus-host disease_Homo sapiens_hsa053321.75517288
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64168813
21Nucleotide excision repair_Homo sapiens_hsa034201.55992902
22Homologous recombination_Homo sapiens_hsa034401.54517944
23Base excision repair_Homo sapiens_hsa034101.49935407
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.47561150
25Antigen processing and presentation_Homo sapiens_hsa046121.41568474
26Fanconi anemia pathway_Homo sapiens_hsa034601.39807483
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25336101
28Spliceosome_Homo sapiens_hsa030401.22280774
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22226569
30Cardiac muscle contraction_Homo sapiens_hsa042601.21681209
31Legionellosis_Homo sapiens_hsa051341.19898616
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18583264
33Measles_Homo sapiens_hsa051621.18179972
34Sulfur metabolism_Homo sapiens_hsa009201.17595380
35Glutathione metabolism_Homo sapiens_hsa004801.16511600
36Pentose phosphate pathway_Homo sapiens_hsa000301.13592408
37Autoimmune thyroid disease_Homo sapiens_hsa053201.12368017
38Leishmaniasis_Homo sapiens_hsa051401.11607375
39Carbon metabolism_Homo sapiens_hsa012001.10153328
40Purine metabolism_Homo sapiens_hsa002301.08135790
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04215742
42Pyruvate metabolism_Homo sapiens_hsa006201.04203502
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03685143
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03076198
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02631687
46B cell receptor signaling pathway_Homo sapiens_hsa046620.99542213
47One carbon pool by folate_Homo sapiens_hsa006700.97939348
48Type I diabetes mellitus_Homo sapiens_hsa049400.96254145
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94792389
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.94627803
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94258024
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93991541
53Asthma_Homo sapiens_hsa053100.90969744
54RNA degradation_Homo sapiens_hsa030180.89308138
55Epstein-Barr virus infection_Homo sapiens_hsa051690.88809738
56Hematopoietic cell lineage_Homo sapiens_hsa046400.88615217
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88361829
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88165186
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88120971
60Non-homologous end-joining_Homo sapiens_hsa034500.87878495
61Rheumatoid arthritis_Homo sapiens_hsa053230.86742599
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86731493
63Herpes simplex infection_Homo sapiens_hsa051680.85549173
64Viral myocarditis_Homo sapiens_hsa054160.81786769
65Folate biosynthesis_Homo sapiens_hsa007900.77005046
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76549101
67Tryptophan metabolism_Homo sapiens_hsa003800.75347423
68Shigellosis_Homo sapiens_hsa051310.73926921
69Sulfur relay system_Homo sapiens_hsa041220.73145043
70RNA transport_Homo sapiens_hsa030130.72809502
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72712114
72Collecting duct acid secretion_Homo sapiens_hsa049660.72566056
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.71866858
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.69763209
75Phagosome_Homo sapiens_hsa041450.69480481
76Apoptosis_Homo sapiens_hsa042100.69081729
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66240565
78Steroid biosynthesis_Homo sapiens_hsa001000.65750610
79Basal transcription factors_Homo sapiens_hsa030220.65605836
80Vibrio cholerae infection_Homo sapiens_hsa051100.61492082
81Propanoate metabolism_Homo sapiens_hsa006400.61278280
82Fructose and mannose metabolism_Homo sapiens_hsa000510.60670954
83Malaria_Homo sapiens_hsa051440.60115730
84Tuberculosis_Homo sapiens_hsa051520.58760954
85Regulation of autophagy_Homo sapiens_hsa041400.58391774
86Metabolic pathways_Homo sapiens_hsa011000.57127223
87p53 signaling pathway_Homo sapiens_hsa041150.56951680
88Pertussis_Homo sapiens_hsa051330.56533232
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.56418217
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.56004852
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55885084
92Chemical carcinogenesis_Homo sapiens_hsa052040.55215505
93Fatty acid degradation_Homo sapiens_hsa000710.53942065
94Peroxisome_Homo sapiens_hsa041460.50442468
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49965567
96Phototransduction_Homo sapiens_hsa047440.49476005
97Arachidonic acid metabolism_Homo sapiens_hsa005900.49466924
98Systemic lupus erythematosus_Homo sapiens_hsa053220.49095790
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48497740
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48396067
101Other glycan degradation_Homo sapiens_hsa005110.48275991
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47298218
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47183433
104Caffeine metabolism_Homo sapiens_hsa002320.45039486
105Selenocompound metabolism_Homo sapiens_hsa004500.44615002
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44532552
107Butanoate metabolism_Homo sapiens_hsa006500.43638538
108Influenza A_Homo sapiens_hsa051640.42388222
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42284830
110Biosynthesis of amino acids_Homo sapiens_hsa012300.42213827
111beta-Alanine metabolism_Homo sapiens_hsa004100.42080830
112Cell cycle_Homo sapiens_hsa041100.41157055
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40759259
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39955197
115Staphylococcus aureus infection_Homo sapiens_hsa051500.39604411
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39356501
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39348683
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38845725
119Galactose metabolism_Homo sapiens_hsa000520.38782902
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38451305
121T cell receptor signaling pathway_Homo sapiens_hsa046600.38084835
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36889609
123Osteoclast differentiation_Homo sapiens_hsa043800.36263008
124Lysosome_Homo sapiens_hsa041420.34037296
125Hepatitis B_Homo sapiens_hsa051610.33962610
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33322473
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31424482
128Fatty acid metabolism_Homo sapiens_hsa012120.30715561
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30702400
130Phenylalanine metabolism_Homo sapiens_hsa003600.30275303

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