SDC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.82124966
2hemidesmosome assembly (GO:0031581)5.41012051
3cell adhesion mediated by integrin (GO:0033627)4.94941575
4cell aggregation (GO:0098743)4.62026140
5cartilage condensation (GO:0001502)4.62026140
6uronic acid metabolic process (GO:0006063)4.57478417
7glucuronate metabolic process (GO:0019585)4.57478417
8cellular glucuronidation (GO:0052695)4.53462013
9positive regulation of extracellular matrix organization (GO:1903055)4.46387669
10surfactant homeostasis (GO:0043129)4.27311456
11notochord development (GO:0030903)4.25335289
12Golgi transport vesicle coating (GO:0048200)4.15220656
13COPI coating of Golgi vesicle (GO:0048205)4.15220656
14keratan sulfate catabolic process (GO:0042340)4.02050314
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.96631589
16bundle of His cell to Purkinje myocyte communication (GO:0086069)3.94420083
17positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.87425077
18protein localization to endosome (GO:0036010)3.72883661
19cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.70975618
20chondrocyte development (GO:0002063)3.69126279
21hydrogen peroxide biosynthetic process (GO:0050665)3.66098383
22limb bud formation (GO:0060174)3.55288204
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55229171
24regulation of water loss via skin (GO:0033561)3.49658708
25regulation of apoptotic process involved in morphogenesis (GO:1902337)3.45207248
26cellular response to interferon-alpha (GO:0035457)3.42105624
27membrane raft organization (GO:0031579)3.40356791
28cell-substrate junction assembly (GO:0007044)3.39798045
29chemical homeostasis within a tissue (GO:0048875)3.37905657
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35870146
31regulation of transforming growth factor beta1 production (GO:0032908)3.34118955
32epithelial cell-cell adhesion (GO:0090136)3.31961918
33keratinocyte proliferation (GO:0043616)3.30609985
34negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.26860706
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.25777500
36regulation of transforming growth factor beta2 production (GO:0032909)3.24859458
37positive regulation of interferon-alpha production (GO:0032727)3.24218701
38diterpenoid biosynthetic process (GO:0016102)3.23711655
39protein retention in ER lumen (GO:0006621)3.23149780
40endothelial cell morphogenesis (GO:0001886)3.21658577
41positive regulation of cellular amide metabolic process (GO:0034250)3.16917251
42regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.15837673
43negative regulation of fibrinolysis (GO:0051918)3.15037423
44superoxide anion generation (GO:0042554)3.12625055
45reactive oxygen species biosynthetic process (GO:1903409)3.06922399
46collagen fibril organization (GO:0030199)3.06434024
47response to peptidoglycan (GO:0032494)3.06379355
48regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.05631660
49regulation of interferon-alpha production (GO:0032647)3.04664791
50negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.04392586
51regulation of extracellular matrix organization (GO:1903053)3.02410023
52positive regulation by symbiont of host defense response (GO:0052509)3.01009859
53modulation by symbiont of host defense response (GO:0052031)3.01009859
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01009859
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01009859
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.01009859
57modulation by symbiont of host immune response (GO:0052553)3.01009859
58multicellular organismal water homeostasis (GO:0050891)3.00172600
59positive regulation of p38MAPK cascade (GO:1900745)2.98655948
60hypotonic response (GO:0006971)2.97493714
61xenobiotic catabolic process (GO:0042178)2.96817918
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93144389
63regulation of heterotypic cell-cell adhesion (GO:0034114)2.92417696
64establishment of skin barrier (GO:0061436)2.92163053
65regulation of extracellular matrix disassembly (GO:0010715)2.89959162
66gap junction assembly (GO:0016264)2.88486248
67regulation of membrane protein ectodomain proteolysis (GO:0051043)2.88142561
68positive regulation of monocyte chemotaxis (GO:0090026)2.85265264
69endocardial cushion morphogenesis (GO:0003203)2.85134083
70negative regulation of keratinocyte proliferation (GO:0010839)2.83984287
71peptidyl-glutamic acid carboxylation (GO:0017187)2.83816678
72protein carboxylation (GO:0018214)2.83816678
73mesodermal cell differentiation (GO:0048333)2.83395894
74regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.82130293
75lung vasculature development (GO:0060426)2.82016606
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.80396689
77neutrophil activation involved in immune response (GO:0002283)2.78897152
78mammary gland epithelial cell proliferation (GO:0033598)2.78364806
79wound healing, spreading of epidermal cells (GO:0035313)2.77613137
80cyclooxygenase pathway (GO:0019371)2.75978903
81muscle cell migration (GO:0014812)2.75871655
82endodermal cell differentiation (GO:0035987)2.75125108
83iron ion import (GO:0097286)2.74984048
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74878889
85regulation of metalloenzyme activity (GO:0048552)2.74537608
86negative regulation of cytokine secretion (GO:0050710)2.74166333
87regulation of plasminogen activation (GO:0010755)2.73069263
88negative regulation of lipid storage (GO:0010888)2.71440793
89regulation of fever generation (GO:0031620)2.70865979
90cellular copper ion homeostasis (GO:0006878)2.70343724
91fibrinolysis (GO:0042730)2.69919743
92decidualization (GO:0046697)2.69055952
93prostanoid metabolic process (GO:0006692)2.68767663
94prostaglandin metabolic process (GO:0006693)2.68767663
95negative regulation of chondrocyte differentiation (GO:0032331)2.68669775
96heart valve morphogenesis (GO:0003179)2.68443252
97branching involved in mammary gland duct morphogenesis (GO:0060444)2.67335366
98regulation of mononuclear cell migration (GO:0071675)2.66960982
99bone remodeling (GO:0046849)2.66942684
100regulation of vitamin D biosynthetic process (GO:0060556)2.66704882
101regulation of integrin-mediated signaling pathway (GO:2001044)2.66614815
102nucleotide-sugar biosynthetic process (GO:0009226)2.61291282
103branching involved in labyrinthine layer morphogenesis (GO:0060670)2.61027408
104positive regulation of male gonad development (GO:2000020)2.60779218
105regulation of transforming growth factor beta production (GO:0071634)2.59126095
106detection of molecule of bacterial origin (GO:0032490)2.58120409
107positive regulation of type 2 immune response (GO:0002830)2.57265884
108barbed-end actin filament capping (GO:0051016)2.56446102
109regulation of interleukin-8 secretion (GO:2000482)2.56217397
110substrate-dependent cell migration (GO:0006929)2.55234681
111tight junction assembly (GO:0070830)2.53157145
112response to nitrosative stress (GO:0051409)2.52737932
113regulation of male gonad development (GO:2000018)2.52424103
114regulation of fibrinolysis (GO:0051917)2.51516556
115protein hydroxylation (GO:0018126)2.51335157
116positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51242486
117glomerular visceral epithelial cell development (GO:0072015)2.50926663
118regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49594157
119calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49272951
120apoptotic cell clearance (GO:0043277)2.49118223
121production of molecular mediator involved in inflammatory response (GO:0002532)2.48982024
122inflammatory response to antigenic stimulus (GO:0002437)2.48547866
123regulation of phospholipase A2 activity (GO:0032429)2.47647341
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.46689489
125positive regulation of heat generation (GO:0031652)2.45921308
126water homeostasis (GO:0030104)2.45883983
127negative regulation of coagulation (GO:0050819)2.45482663
128response to interferon-alpha (GO:0035455)2.45216608
129virion attachment to host cell (GO:0019062)2.44549676
130adhesion of symbiont to host cell (GO:0044650)2.44549676
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43866871
132regulation of heat generation (GO:0031650)2.43139509
133negative regulation of complement activation (GO:0045916)2.42139428
134branching involved in salivary gland morphogenesis (GO:0060445)2.42075395
135regulation of complement activation (GO:0030449)2.40861193
136interferon-gamma secretion (GO:0072643)2.40724026
137negative regulation of fatty acid transport (GO:2000192)2.40413930
138negative regulation of protein activation cascade (GO:2000258)2.40181346
139cell-substrate adherens junction assembly (GO:0007045)2.39917411
140focal adhesion assembly (GO:0048041)2.39917411
141regulation of vitamin metabolic process (GO:0030656)2.39894706
142membrane protein ectodomain proteolysis (GO:0006509)2.39775900
143oligosaccharide catabolic process (GO:0009313)2.39771696
144eosinophil chemotaxis (GO:0048245)2.39097815
145response to muramyl dipeptide (GO:0032495)2.38966173
146regulation of protein activation cascade (GO:2000257)2.38929223
147peptidyl-proline hydroxylation (GO:0019511)2.37825083
148wound healing, spreading of cells (GO:0044319)2.37550349
149adherens junction assembly (GO:0034333)2.37481771
150negative regulation of protein secretion (GO:0050709)2.36181860
151negative regulation of blood coagulation (GO:0030195)2.35772717
152negative regulation of hemostasis (GO:1900047)2.35772717
153negative regulation of wound healing (GO:0061045)2.35588552
154mesenchyme morphogenesis (GO:0072132)2.35504017
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.35198445
156endocytic recycling (GO:0032456)2.34899339
157glycosphingolipid catabolic process (GO:0046479)2.34418753
158low-density lipoprotein particle remodeling (GO:0034374)2.34242667
159prostanoid biosynthetic process (GO:0046457)2.33782306
160prostaglandin biosynthetic process (GO:0001516)2.33782306
161positive regulation of interferon-beta production (GO:0032728)2.32815172
162granulocyte activation (GO:0036230)2.32426394
163adhesion of symbiont to host (GO:0044406)2.32207582
164establishment of apical/basal cell polarity (GO:0035089)2.31934064
165regulation of cardioblast differentiation (GO:0051890)2.31583905
166positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.30285776
167neural crest cell development (GO:0014032)2.30210387
168lipoxygenase pathway (GO:0019372)2.29259971
169pinocytosis (GO:0006907)2.28924283
170regulation of superoxide anion generation (GO:0032928)2.27428220
171folic acid transport (GO:0015884)2.26737179
172chondroitin sulfate biosynthetic process (GO:0030206)2.26397232
173macrophage activation involved in immune response (GO:0002281)2.26143287
174phospholipid efflux (GO:0033700)2.25746066
175microglial cell activation (GO:0001774)2.25694492
176positive regulation of chemokine biosynthetic process (GO:0045080)2.25270053
177regulation of cholesterol esterification (GO:0010872)2.25181561
178indole-containing compound catabolic process (GO:0042436)2.24879909
179indolalkylamine catabolic process (GO:0046218)2.24879909
180tryptophan catabolic process (GO:0006569)2.24879909
181lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24655770
182negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.24316569
183positive regulation of endothelial cell differentiation (GO:0045603)2.23768887
184heart valve formation (GO:0003188)2.23377175
185skin morphogenesis (GO:0043589)2.23250257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.02670709
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.94015893
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.38436074
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.01436935
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.05887775
6* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04410991
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99542151
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.71964099
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.70043143
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.67986506
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.59191963
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48153526
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43400025
14* RXR_22158963_ChIP-Seq_LIVER_Mouse2.41419625
15ZNF263_19887448_ChIP-Seq_K562_Human2.40832580
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.40632524
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34281905
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.31758285
19AR_21572438_ChIP-Seq_LNCaP_Human2.18821701
20* LXR_22158963_ChIP-Seq_LIVER_Mouse2.17943482
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.15205871
22CJUN_26792858_Chip-Seq_BT549_Human2.09565337
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.09447185
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.04734995
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01016065
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.96111054
27* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96084672
28SOX2_20726797_ChIP-Seq_SW620_Human1.90556295
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90013809
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.88358975
31GATA1_22025678_ChIP-Seq_K562_Human1.87747155
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85822912
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85822912
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85339013
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85339013
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85323454
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82613679
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.79529632
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.79037534
40ATF3_27146783_Chip-Seq_COLON_Human1.76959598
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76232170
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75784165
43* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70667713
44* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68668659
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67292202
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.66375005
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66265258
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60639414
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58580188
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58248903
51CLOCK_20551151_ChIP-Seq_293T_Human1.55547653
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51920163
53* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51587875
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51565761
55AR_21909140_ChIP-Seq_LNCAP_Human1.49962790
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44819332
57VDR_24787735_ChIP-Seq_THP-1_Human1.44237753
58* TP53_18474530_ChIP-ChIP_U2OS_Human1.42235888
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40492248
60* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40082845
61* CDX2_20551321_ChIP-Seq_CACO-2_Human1.38235814
62* GATA6_25053715_ChIP-Seq_YYC3_Human1.38003072
63* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36667562
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35616104
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33443166
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32966767
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32662743
68* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.31742511
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29324466
70* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28332816
71RXR_22108803_ChIP-Seq_LS180_Human1.26602624
72* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25629607
73* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25081984
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23181013
75* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20357013
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19848706
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18984568
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18524455
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.18276169
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17315420
81* GATA4_25053715_ChIP-Seq_YYC3_Human1.14743743
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.13267189
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.13102523
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12628016
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12006965
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11294827
87* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09045938
88* KLF5_25053715_ChIP-Seq_YYC3_Human1.08479564
89* TP63_23658742_ChIP-Seq_EP156T_Human1.08272813
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08134884
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07881647
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07353962
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06969933
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06245399
95* GATA3_24758297_ChIP-Seq_MCF-7_Human1.06238959
96AHR_22903824_ChIP-Seq_MCF-7_Human1.05525491
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.05223263
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05046620
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04946753
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04448878
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04267118
102TP53_22127205_ChIP-Seq_IMR90_Human1.03865883
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03622215
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03612467
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03278801
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.02715541
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.02715541
108* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02408081
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02189019
110LXR_22292898_ChIP-Seq_THP-1_Human1.01744494
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.96985688
112* BRD4_25478319_ChIP-Seq_HGPS_Human0.94814666
113* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94325732
114* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93928182
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.92970753
116EGR1_19032775_ChIP-ChIP_M12_Human0.92583277
117* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89996242
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89923966
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89698071
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89234937
121* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88692750
122WT1_19549856_ChIP-ChIP_CCG9911_Human0.88513119
123* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85117474
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.84859396
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83648607
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81798123
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81370412
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80603654
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79524346
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78130707
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76790721
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.76141254
133PU_27001747_Chip-Seq_BMDM_Mouse0.74919331
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71170470
135* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70924199
136TP53_16413492_ChIP-PET_HCT116_Human0.67890843
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67151253
138PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.66824331
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.66479435
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66207369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.19553518
2MP0003195_calcinosis2.99711869
3MP0003436_decreased_susceptibility_to2.95952017
4MP0002282_abnormal_trachea_morphology2.75848527
5MP0010352_gastrointestinal_tract_polyps2.72870140
6MP0002933_joint_inflammation2.68337014
7MP0002139_abnormal_hepatobiliary_system2.54559022
8MP0002148_abnormal_hypersensitivity_rea2.45348768
9MP0003941_abnormal_skin_development2.40664882
10MP0002254_reproductive_system_inflammat2.36039575
11MP0001533_abnormal_skeleton_physiology2.32798036
12MP0002877_abnormal_melanocyte_morpholog2.22144745
13MP0009780_abnormal_chondrocyte_physiolo2.22024401
14MP0005257_abnormal_intraocular_pressure2.20850911
15MP0005503_abnormal_tendon_morphology2.11409164
16MP0005275_abnormal_skin_tensile2.03857563
17MP0008004_abnormal_stomach_pH2.01592644
18MP0008438_abnormal_cutaneous_collagen2.00167457
19MP0003724_increased_susceptibility_to1.99619474
20MP0005390_skeleton_phenotype1.95892994
21MP0004782_abnormal_surfactant_physiolog1.95852805
22MP0001542_abnormal_bone_strength1.94874392
23MP0001835_abnormal_antigen_presentation1.92969433
24MP0003186_abnormal_redox_activity1.92618104
25MP0004264_abnormal_extraembryonic_tissu1.92491368
26MP0001853_heart_inflammation1.86267243
27MP0006054_spinal_hemorrhage1.82374693
28MP0003705_abnormal_hypodermis_morpholog1.81900900
29MP0000163_abnormal_cartilage_morphology1.78575951
30MP0009840_abnormal_foam_cell1.78019003
31MP0010678_abnormal_skin_adnexa1.77321723
32MP0004134_abnormal_chest_morphology1.76806934
33MP0005058_abnormal_lysosome_morphology1.68855309
34MP0000579_abnormal_nail_morphology1.64306518
35MP0009250_abnormal_appendicular_skeleto1.60600696
36MP0005623_abnormal_meninges_morphology1.60149894
37MP0009764_decreased_sensitivity_to1.59791699
38MP0000762_abnormal_tongue_morphology1.59119632
39MP0005501_abnormal_skin_physiology1.58663602
40MP0002419_abnormal_innate_immunity1.58443115
41MP0002060_abnormal_skin_morphology1.58141353
42MP0009384_cardiac_valve_regurgitation1.57791552
43MP0005360_urolithiasis1.57452948
44MP0005508_abnormal_skeleton_morphology1.55922414
45MP0009785_altered_susceptibility_to1.54832103
46MP0005085_abnormal_gallbladder_physiolo1.49125739
47MP0005451_abnormal_body_composition1.47633258
48MP0002998_abnormal_bone_remodeling1.46692228
49* MP0003091_abnormal_cell_migration1.46114324
50MP0003279_aneurysm1.45639022
51MP0001849_ear_inflammation1.43602561
52MP0005164_abnormal_response_to1.43278636
53MP0010030_abnormal_orbit_morphology1.42406752
54MP0006082_CNS_inflammation1.42373381
55MP0000858_altered_metastatic_potential1.42145895
56MP0002115_abnormal_skeleton_extremities1.41159527
57MP0005000_abnormal_immune_tolerance1.37469442
58MP0005165_increased_susceptibility_to1.37359154
59MP0000467_abnormal_esophagus_morphology1.37053850
60MP0000537_abnormal_urethra_morphology1.35207942
61MP0002098_abnormal_vibrissa_morphology1.30383392
62MP0001790_abnormal_immune_system1.30248384
63MP0005387_immune_system_phenotype1.30248384
64MP0004019_abnormal_vitamin_homeostasis1.30193459
65MP0002113_abnormal_skeleton_development1.28841571
66MP0000343_altered_response_to1.28443494
67MP0003300_gastrointestinal_ulcer1.28383774
68* MP0005023_abnormal_wound_healing1.26184601
69MP0002295_abnormal_pulmonary_circulatio1.23680644
70MP0003795_abnormal_bone_structure1.22124771
71MP0008875_abnormal_xenobiotic_pharmacok1.20624230
72MP0000627_abnormal_mammary_gland1.18864464
73MP0002896_abnormal_bone_mineralization1.16598803
74MP0010368_abnormal_lymphatic_system1.16382065
75MP0000566_synostosis1.15327750
76MP0003448_altered_tumor_morphology1.14607516
77MP0010771_integument_phenotype1.14361753
78MP0001958_emphysema1.14320937
79MP0001216_abnormal_epidermal_layer1.12503304
80MP0005025_abnormal_response_to1.12488484
81MP0003075_altered_response_to1.10418246
82MP0003453_abnormal_keratinocyte_physiol1.10258938
83MP0002796_impaired_skin_barrier1.09925340
84MP0004510_myositis1.06981333
85MP0005166_decreased_susceptibility_to1.06799436
86MP0000383_abnormal_hair_follicle1.06460478
87MP0008469_abnormal_protein_level1.06075502
88MP0002277_abnormal_respiratory_mucosa1.01708079
89MP0004272_abnormal_basement_membrane1.01550487
90MP0004947_skin_inflammation1.00499781
91MP0001346_abnormal_lacrimal_gland0.99958929
92MP0001666_abnormal_nutrient_absorption0.98742189
93MP0002138_abnormal_hepatobiliary_system0.98191698
94MP0003303_peritoneal_inflammation0.96806733
95MP0002168_other_aberrant_phenotype0.95776146
96MP0001177_atelectasis0.95447279
97MP0001881_abnormal_mammary_gland0.95439214
98MP0001845_abnormal_inflammatory_respons0.94801319
99MP0004381_abnormal_hair_follicle0.94335923
100MP0002452_abnormal_antigen_presenting0.94193197
101MP0005365_abnormal_bile_salt0.93861089
102MP0002136_abnormal_kidney_physiology0.92791996
103MP0002405_respiratory_system_inflammati0.92689016
104MP0000678_abnormal_parathyroid_gland0.91362089
105MP0005083_abnormal_biliary_tract0.89268126
106MP0005076_abnormal_cell_differentiation0.89124605
107MP0001243_abnormal_dermal_layer0.88928347
108MP0003755_abnormal_palate_morphology0.87058774
109MP0010155_abnormal_intestine_physiology0.86580586
110MP0002163_abnormal_gland_morphology0.86138863
111MP0009053_abnormal_anal_canal0.86038246
112MP0003191_abnormal_cellular_cholesterol0.85652560
113MP0003136_yellow_coat_color0.85304623
114MP0005409_darkened_coat_color0.84741347
115MP0005197_abnormal_uvea_morphology0.84254567
116* MP0003566_abnormal_cell_adhesion0.84245893
117MP0002089_abnormal_postnatal_growth/wei0.83634510
118MP0003690_abnormal_glial_cell0.83368466
119MP0000733_abnormal_muscle_development0.82973653
120MP0005408_hypopigmentation0.81829287
121MP0000647_abnormal_sebaceous_gland0.81668971
122MP0002233_abnormal_nose_morphology0.81562041
123MP0009931_abnormal_skin_appearance0.81156280
124MP0004185_abnormal_adipocyte_glucose0.81036196
125MP0004858_abnormal_nervous_system0.80692706
126MP0000377_abnormal_hair_follicle0.79795915
127MP0002249_abnormal_larynx_morphology0.78719937
128MP0004233_abnormal_muscle_weight0.78669815
129MP0000049_abnormal_middle_ear0.78524109
130MP0005395_other_phenotype0.78456486
131MP0000685_abnormal_immune_system0.77865850
132MP0003950_abnormal_plasma_membrane0.77581847
133MP0002332_abnormal_exercise_endurance0.77237537
134MP0002132_abnormal_respiratory_system0.76600471
135MP0000767_abnormal_smooth_muscle0.76564297
136MP0003806_abnormal_nucleotide_metabolis0.76054007
137MP0000003_abnormal_adipose_tissue0.75050771
138MP0001348_abnormal_lacrimal_gland0.74137494
139MP0001851_eye_inflammation0.73667437
140MP0005375_adipose_tissue_phenotype0.66217894
141MP0000534_abnormal_ureter_morphology0.63922478
142MP0009643_abnormal_urine_homeostasis0.63576149
143MP0005595_abnormal_vascular_smooth0.62100213

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.00877331
2Vitreoretinal degeneration (HP:0000655)6.69345665
3Irregular epiphyses (HP:0010582)6.26631505
4Cupped ribs (HP:0000887)5.28934800
5Abnormal tarsal ossification (HP:0008369)4.97099496
6Hypoplastic ischia (HP:0003175)4.63626280
7Neonatal short-limb short stature (HP:0008921)4.33830977
8Flat capital femoral epiphysis (HP:0003370)4.27928172
9Abnormality of the ischium (HP:0003174)4.16736911
10Flat acetabular roof (HP:0003180)4.13562521
11Small epiphyses (HP:0010585)4.01456572
12Right ventricular cardiomyopathy (HP:0011663)3.93322926
13Delayed epiphyseal ossification (HP:0002663)3.90585958
14Atrophic scars (HP:0001075)3.83618636
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.75209550
16Protrusio acetabuli (HP:0003179)3.73059992
17Arthropathy (HP:0003040)3.69557318
18Abnormal foot bone ossification (HP:0010675)3.60446202
19Genu varum (HP:0002970)3.52177078
20Interstitial pulmonary disease (HP:0006530)3.30482323
21Metaphyseal cupping (HP:0003021)3.28958101
22Alopecia of scalp (HP:0002293)3.22554819
23Arterial tortuosity (HP:0005116)3.19051159
24Metaphyseal irregularity (HP:0003025)3.17303610
25Vascular tortuosity (HP:0004948)3.14467469
26Abnormality of the phalanges of the 2nd finger (HP:0009541)3.10345969
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.05879161
28Abnormal vertebral ossification (HP:0100569)3.02562969
29Osteoarthritis (HP:0002758)2.99509369
30Onycholysis (HP:0001806)2.97163369
31Deep venous thrombosis (HP:0002625)2.94907729
32Protuberant abdomen (HP:0001538)2.92243804
33Flattened epiphyses (HP:0003071)2.90541671
34Abnormality of the vertebral endplates (HP:0005106)2.86600581
35Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.86190699
36Abnormality of femoral epiphyses (HP:0006499)2.86190699
37Cervical subluxation (HP:0003308)2.85759150
38Abnormality of the distal phalanges of the toes (HP:0010182)2.80633232
39Absent frontal sinuses (HP:0002688)2.80165565
40Abnormality of incisor morphology (HP:0011063)2.76068750
41Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.73813096
42Milia (HP:0001056)2.71013839
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.69826315
44Abnormality of carpal bone ossification (HP:0006257)2.69224222
45Natal tooth (HP:0000695)2.68852177
46Mitral stenosis (HP:0001718)2.67286157
47Fragile skin (HP:0001030)2.66868769
48Short femoral neck (HP:0100864)2.65680263
49Follicular hyperkeratosis (HP:0007502)2.64619116
50Absent epiphyses (HP:0010577)2.60798477
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.60798477
52Thick nail (HP:0001805)2.60765282
53Stillbirth (HP:0003826)2.60202386
54Plantar hyperkeratosis (HP:0007556)2.56034498
55Aortic dissection (HP:0002647)2.54219899
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.51907738
57Metaphyseal dysplasia (HP:0100255)2.51817177
58Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.50041742
59Myocardial infarction (HP:0001658)2.47992687
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.45285527
61Fibular hypoplasia (HP:0003038)2.44757829
62Irregular vertebral endplates (HP:0003301)2.44607969
63Vascular calcification (HP:0004934)2.43673047
64Abnormality of complement system (HP:0005339)2.43556306
65Short nail (HP:0001799)2.43092173
66Thin ribs (HP:0000883)2.42351555
67Abnormality of glycolipid metabolism (HP:0010969)2.42350459
68Abnormality of liposaccharide metabolism (HP:0010968)2.42350459
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.42350459
70Fragile nails (HP:0001808)2.41344954
71Coxa vara (HP:0002812)2.38291549
72Enlarged epiphyses (HP:0010580)2.37046948
73Abnormality of the femoral head (HP:0003368)2.36567052
74Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.34092139
75Vertebral hypoplasia (HP:0008417)2.34092139
76Complement deficiency (HP:0004431)2.33473233
77Distal lower limb muscle weakness (HP:0009053)2.32392399
78Nail dystrophy (HP:0008404)2.32390682
79Neurofibrillary tangles (HP:0002185)2.31307380
80Systemic lupus erythematosus (HP:0002725)2.31240627
81Cardiovascular calcification (HP:0011915)2.29428663
82Aplasia/Hypoplasia of the scapulae (HP:0006713)2.28972181
83Hypoplastic scapulae (HP:0000882)2.28972181
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.28921923
85Beaking of vertebral bodies (HP:0004568)2.25026772
86Sparse eyelashes (HP:0000653)2.22396230
87Barrel-shaped chest (HP:0001552)2.21839266
88Popliteal pterygium (HP:0009756)2.21265051
89Pterygium (HP:0001059)2.20526416
90Glucose intolerance (HP:0000833)2.19931179
91Thoracolumbar scoliosis (HP:0002944)2.19682136
92Advanced eruption of teeth (HP:0006288)2.17779508
93Mild short stature (HP:0003502)2.17192826
94Pili torti (HP:0003777)2.16534768
95Aortic aneurysm (HP:0004942)2.15958878
96Platyspondyly (HP:0000926)2.15443260
97Abnormality of proline metabolism (HP:0010907)2.15344469
98Hydroxyprolinuria (HP:0003080)2.15344469
99Mildly elevated creatine phosphokinase (HP:0008180)2.14741459
100Abnormality of the Achilles tendon (HP:0005109)2.12391205
101Nuclear cataract (HP:0100018)2.12004848
102Abnormality of nail color (HP:0100643)2.11766776
103Distal upper limb amyotrophy (HP:0007149)2.09963635
104Upper limb amyotrophy (HP:0009129)2.09963635
105Hypoplasia of dental enamel (HP:0006297)2.09194385
106Abnormality of the frontal sinuses (HP:0002687)2.08291928
107Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.07093881
108Osteolytic defects of the hand bones (HP:0009699)2.06745355
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.06745355
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06729365
111Abnormality of the 2nd finger (HP:0004100)2.06395659
112Ovoid vertebral bodies (HP:0003300)2.05630295
113Ankle contracture (HP:0006466)2.05436432
114Distal lower limb amyotrophy (HP:0008944)2.05102632
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.04594841
116Axonal loss (HP:0003447)2.03974976
117Palmoplantar hyperkeratosis (HP:0000972)2.03177433
118Intrahepatic cholestasis (HP:0001406)2.01876763
119Spinal rigidity (HP:0003306)2.01261805
120Premature rupture of membranes (HP:0001788)2.00736788
121Achilles tendon contracture (HP:0001771)2.00431448
122Wormian bones (HP:0002645)1.99156461
123Abnormality of the lumbar spine (HP:0100712)1.98904921
124Abnormal hand bone ossification (HP:0010660)1.98557576
125Glomerulonephritis (HP:0000099)1.97245829
126Dysostosis multiplex (HP:0000943)1.96615018
127Limited elbow extension (HP:0001377)1.96592003
128Aplasia/hypoplasia of the femur (HP:0005613)1.95916108
129Vacuolated lymphocytes (HP:0001922)1.95301524
130Abnormality of the pubic bones (HP:0003172)1.94480733
131Reduced subcutaneous adipose tissue (HP:0003758)1.93830266
132Xanthomatosis (HP:0000991)1.93109676
133Abnormal hair laboratory examination (HP:0003328)1.92916374
134Patent foramen ovale (HP:0001655)1.92575656
135Abnormal ossification of hand bones (HP:0005921)1.91281919
136Abnormality of the middle phalanges of the toes (HP:0010183)1.90074841
137Cerebral inclusion bodies (HP:0100314)1.90062041
138Lip pit (HP:0100267)1.89985656
139Eczematoid dermatitis (HP:0000976)1.89501047
140Glossoptosis (HP:0000162)1.89398108
141Mixed hearing impairment (HP:0000410)1.89015862
142Elbow flexion contracture (HP:0002987)1.88807527
143Abnormal cartilage morphology (HP:0002763)1.86474689
144Urinary glycosaminoglycan excretion (HP:0003541)1.86465822
145Mucopolysacchariduria (HP:0008155)1.86465822
146Spondylolisthesis (HP:0003302)1.85427339
147Focal segmental glomerulosclerosis (HP:0000097)1.85357804
148Vertebral compression fractures (HP:0002953)1.83887816
149Spinal cord compression (HP:0002176)1.83807826
150Acanthosis nigricans (HP:0000956)1.83703380
151Ulnar bowing (HP:0003031)1.83659784
152Long clavicles (HP:0000890)1.83631491
153Aplasia involving bones of the upper limbs (HP:0009823)1.83018238
154Aplasia of the phalanges of the hand (HP:0009802)1.83018238
155Aplasia involving bones of the extremities (HP:0009825)1.83018238
156Respiratory distress (HP:0002098)1.81983722
157Short middle phalanx of finger (HP:0005819)1.81216113
158Vertebral clefting (HP:0008428)1.80655627
159Trismus (HP:0000211)1.80596407
160Selective tooth agenesis (HP:0001592)1.80452035
161Palmar hyperkeratosis (HP:0010765)1.79893895
162Steatorrhea (HP:0002570)1.79799234
163Blue sclerae (HP:0000592)1.79361116
164Chronic bronchitis (HP:0004469)1.79316018
165Exostoses (HP:0100777)1.79286808
166Hypoalphalipoproteinemia (HP:0003233)1.79109626
167Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78891888
168Submucous cleft hard palate (HP:0000176)1.77994119
169Abnormality of the acetabulum (HP:0003170)1.76795731
170Increased connective tissue (HP:0009025)1.75593381
171Nephritis (HP:0000123)1.75544450
172Pulmonary artery stenosis (HP:0004415)1.75504663
173Abnormality of dentin (HP:0010299)1.74116764
174Abnormal blistering of the skin (HP:0008066)1.74038620
175Fat malabsorption (HP:0002630)1.73987736
176Thin bony cortex (HP:0002753)1.73814305
177Ankyloglossia (HP:0010296)1.73582524
17811 pairs of ribs (HP:0000878)1.73020792
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72141090
180Abnormality of polysaccharide metabolism (HP:0011012)1.72141090
181Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72141090
182Abnormality of the middle phalanges of the hand (HP:0009833)1.72125100
183Glomerulosclerosis (HP:0000096)1.70040665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.52609331
2MST43.76102575
3ERBB33.64453258
4PBK3.45876249
5MAP3K143.20359452
6LATS22.73276204
7BMPR22.72880499
8DDR22.72543443
9STK38L2.64238673
10EPHA22.55821341
11MUSK2.51408379
12IRAK32.47106849
13PIM22.38377128
14STK242.26374336
15TRPM72.17811232
16PAK42.10765373
17PTK22.04723331
18MYLK1.92255247
19MST1R1.84734609
20IKBKB1.83355332
21PDGFRA1.82002576
22MAP3K121.79573001
23MKNK21.78688635
24EPHA31.76609036
25TBK11.72438567
26TRIB31.69188087
27PRKG21.64415144
28TYK21.58932462
29MKNK11.55570272
30IKBKE1.53477218
31ZAK1.50649081
32ERN11.48527867
33CHUK1.36677320
34MAPKAPK31.35824288
35LIMK11.33910433
36SMG11.33733078
37NEK91.32969730
38FGFR41.26599811
39BMX1.23020311
40NTRK11.21283581
41TTN1.18920323
42NUAK11.17832942
43MET1.14116577
44STK31.13582093
45EPHB21.13302391
46PIM11.10887945
47SIK31.07888506
48ARAF1.04508067
49NME11.04149329
50ICK1.03434909
51ERBB41.02930475
52MAP3K91.02498484
53SIK11.02482463
54JAK31.02481212
55IRAK40.99472681
56PLK20.98797193
57NEK60.98068277
58LATS10.96270943
59FGFR30.95233261
60RIPK40.94105204
61STK380.92172668
62JAK10.91682320
63TAOK20.90904905
64EIF2AK20.87944888
65BMPR1B0.86330838
66MAP3K110.86313885
67EIF2AK10.85680325
68FRK0.84685636
69SGK20.84100783
70LMTK20.83087393
71RPS6KA40.80495561
72MAP3K50.76803232
73IRAK10.74454021
74ABL20.72774291
75PDK20.72023134
76NLK0.70849654
77MAPK70.69895712
78TESK10.68848295
79STK100.68781379
80PKN20.68566217
81PDGFRB0.68423303
82MAP2K30.68125124
83PAK20.65572658
84PTK60.64995490
85CDC42BPA0.64300763
86ILK0.64294344
87STK390.63831768
88SCYL20.61096886
89BLK0.60392454
90BCR0.59187963
91MARK30.59157570
92SGK30.58935529
93FER0.56366226
94ABL10.56196047
95EPHB10.56175870
96LRRK20.55813892
97GSK3A0.55359446
98ROCK10.54478917
99EIF2AK30.54385187
100DMPK0.53557639
101TGFBR20.52019294
102TESK20.51092779
103NME20.50163915
104PRKCE0.49919107
105MELK0.49660269
106MTOR0.49447785
107CDK120.47728971
108PRKCI0.47358653
109CDK60.46641330
110ROCK20.45852767
111PIK3CG0.45037955
112MAP3K10.44439695
113CSK0.43281895
114MAP3K80.42633300
115TXK0.41963745
116FLT30.41274465
117RPS6KB20.40538069
118DYRK1A0.40280312
119MOS0.40218771
120MAP3K60.38971092
121BRSK20.38713831
122FGFR10.38487169
123TEC0.38386194
124DAPK30.38223635
125CDK80.38169011
126PRKD20.37735604
127MAPKAPK20.37531191
128CAMK2G0.36925485
129* PRKCD0.36266263
130RPS6KA20.36116900
131MAP2K10.35636620
132MAPK150.35431280
133EEF2K0.35259825
134AKT30.35166243
135PIK3CA0.35107742
136HCK0.34171588
137MAPK40.33657003
138IGF1R0.33242945
139JAK20.33174486
140PRPF4B0.31176030
141GRK70.30264134
142AKT20.29742334
143RPS6KA50.28621374
144TAOK10.28489551
145RIPK10.28328356
146STK40.28053701
147MAP3K20.27809353
148MAPK120.27604877
149IRAK20.27568588
150SGK4940.27273844
151SGK2230.27273844

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.30012493
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00709156
3Staphylococcus aureus infection_Homo sapiens_hsa051502.70909792
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.41707268
5Malaria_Homo sapiens_hsa051442.21873864
6Complement and coagulation cascades_Homo sapiens_hsa046102.21754213
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.20998588
8Chemical carcinogenesis_Homo sapiens_hsa052042.18704060
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17212773
10Graft-versus-host disease_Homo sapiens_hsa053322.00101230
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.97141455
12* ECM-receptor interaction_Homo sapiens_hsa045121.96292719
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88756974
14Sulfur metabolism_Homo sapiens_hsa009201.77070962
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76791784
16Leishmaniasis_Homo sapiens_hsa051401.74661883
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.72247466
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70586126
19Legionellosis_Homo sapiens_hsa051341.67556067
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65036787
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64555039
22Protein digestion and absorption_Homo sapiens_hsa049741.62623343
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.61239436
24Starch and sucrose metabolism_Homo sapiens_hsa005001.55615145
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55107301
26Steroid biosynthesis_Homo sapiens_hsa001001.54655381
27Retinol metabolism_Homo sapiens_hsa008301.53371600
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46178095
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44282913
30TNF signaling pathway_Homo sapiens_hsa046681.40866799
31Other glycan degradation_Homo sapiens_hsa005111.39391347
32Tight junction_Homo sapiens_hsa045301.39310696
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37811769
34Rheumatoid arthritis_Homo sapiens_hsa053231.37735121
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36937679
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31416361
37Vibrio cholerae infection_Homo sapiens_hsa051101.30867869
38Arachidonic acid metabolism_Homo sapiens_hsa005901.29732671
39Allograft rejection_Homo sapiens_hsa053301.28701703
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26416773
41Thyroid cancer_Homo sapiens_hsa052161.25928305
42Pertussis_Homo sapiens_hsa051331.22374541
43Influenza A_Homo sapiens_hsa051641.16501505
44Glutathione metabolism_Homo sapiens_hsa004801.15849286
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15773403
46Histidine metabolism_Homo sapiens_hsa003401.13321971
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.12063257
48Fructose and mannose metabolism_Homo sapiens_hsa000511.11045424
49Peroxisome_Homo sapiens_hsa041461.09898560
50Shigellosis_Homo sapiens_hsa051311.01688715
51Hippo signaling pathway_Homo sapiens_hsa043900.99110413
52African trypanosomiasis_Homo sapiens_hsa051430.98936093
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98898589
54Sphingolipid metabolism_Homo sapiens_hsa006000.98654277
55Osteoclast differentiation_Homo sapiens_hsa043800.98565639
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98089477
57Phenylalanine metabolism_Homo sapiens_hsa003600.96311618
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.96190447
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95807455
60Pentose phosphate pathway_Homo sapiens_hsa000300.93404716
61TGF-beta signaling pathway_Homo sapiens_hsa043500.91932185
62N-Glycan biosynthesis_Homo sapiens_hsa005100.91707844
63Tuberculosis_Homo sapiens_hsa051520.91132226
64Fatty acid degradation_Homo sapiens_hsa000710.91007656
65Tryptophan metabolism_Homo sapiens_hsa003800.90718337
66Toxoplasmosis_Homo sapiens_hsa051450.90276419
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89853665
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.87770426
69Caffeine metabolism_Homo sapiens_hsa002320.87470752
70Phagosome_Homo sapiens_hsa041450.87446729
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87032885
72Measles_Homo sapiens_hsa051620.86689443
73beta-Alanine metabolism_Homo sapiens_hsa004100.86413608
74Prion diseases_Homo sapiens_hsa050200.86362183
75Mineral absorption_Homo sapiens_hsa049780.85540787
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85243399
77Apoptosis_Homo sapiens_hsa042100.85229052
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.84880145
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83870007
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83504743
81Amoebiasis_Homo sapiens_hsa051460.82644010
82Selenocompound metabolism_Homo sapiens_hsa004500.80977777
83PPAR signaling pathway_Homo sapiens_hsa033200.80781729
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80037728
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79855641
86Salmonella infection_Homo sapiens_hsa051320.79133380
87Arginine biosynthesis_Homo sapiens_hsa002200.77362296
88Folate biosynthesis_Homo sapiens_hsa007900.76015890
89Hematopoietic cell lineage_Homo sapiens_hsa046400.75720141
90Asthma_Homo sapiens_hsa053100.75538949
91Herpes simplex infection_Homo sapiens_hsa051680.74299277
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74127143
93Lysosome_Homo sapiens_hsa041420.72669584
94Chronic myeloid leukemia_Homo sapiens_hsa052200.72528699
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70808017
96Nitrogen metabolism_Homo sapiens_hsa009100.70434353
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.70316468
98Hepatitis C_Homo sapiens_hsa051600.69777313
99Pancreatic cancer_Homo sapiens_hsa052120.67642645
100Bile secretion_Homo sapiens_hsa049760.66918864
101Vitamin digestion and absorption_Homo sapiens_hsa049770.65404036
102Biosynthesis of amino acids_Homo sapiens_hsa012300.64118050
103Focal adhesion_Homo sapiens_hsa045100.62844062
104Endocytosis_Homo sapiens_hsa041440.61965052
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61933925
106One carbon pool by folate_Homo sapiens_hsa006700.60589581
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.59873454
108p53 signaling pathway_Homo sapiens_hsa041150.59225653
109Galactose metabolism_Homo sapiens_hsa000520.58207053
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57593520
111Renal cell carcinoma_Homo sapiens_hsa052110.57542514
112Arginine and proline metabolism_Homo sapiens_hsa003300.56830701
113Insulin resistance_Homo sapiens_hsa049310.56729845
114* Proteoglycans in cancer_Homo sapiens_hsa052050.56084269
115Tyrosine metabolism_Homo sapiens_hsa003500.54160583
116Dilated cardiomyopathy_Homo sapiens_hsa054140.53535213
117Adherens junction_Homo sapiens_hsa045200.52956508
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52862193
119Autoimmune thyroid disease_Homo sapiens_hsa053200.51048365
120Type I diabetes mellitus_Homo sapiens_hsa049400.49578899
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47893385
122Prostate cancer_Homo sapiens_hsa052150.47343437
123Pathways in cancer_Homo sapiens_hsa052000.46287536
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45287628
125Circadian rhythm_Homo sapiens_hsa047100.43910094
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43214221
127Hepatitis B_Homo sapiens_hsa051610.42687635
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39525853
129Vitamin B6 metabolism_Homo sapiens_hsa007500.38430316
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38182614
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.37177158
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35267808
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35223414
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.32266361
135Small cell lung cancer_Homo sapiens_hsa052220.31806338
136Fatty acid metabolism_Homo sapiens_hsa012120.28942470
137Bladder cancer_Homo sapiens_hsa052190.28196485
138MicroRNAs in cancer_Homo sapiens_hsa052060.28064132

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