SDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)6.70826959
2regulation of water loss via skin (GO:0033561)6.53153464
3keratinocyte proliferation (GO:0043616)6.06839520
4cell-substrate junction assembly (GO:0007044)6.00275177
5negative regulation of keratinocyte proliferation (GO:0010839)5.24940803
6surfactant homeostasis (GO:0043129)5.20916492
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.09208098
8L-phenylalanine catabolic process (GO:0006559)5.09208098
9multicellular organismal water homeostasis (GO:0050891)5.06047785
10L-phenylalanine metabolic process (GO:0006558)5.02965743
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.02965743
12negative regulation of fibrinolysis (GO:0051918)4.97136717
13keratinization (GO:0031424)4.89242429
14hemidesmosome assembly (GO:0031581)4.84518981
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77334377
16protein carboxylation (GO:0018214)4.75758109
17peptidyl-glutamic acid carboxylation (GO:0017187)4.75758109
18desmosome organization (GO:0002934)4.69734218
19gap junction assembly (GO:0016264)4.64485845
20regulation of fibrinolysis (GO:0051917)4.55334302
21aromatic amino acid family catabolic process (GO:0009074)4.52578246
22urea metabolic process (GO:0019627)4.52021530
23urea cycle (GO:0000050)4.52021530
24sulfur amino acid catabolic process (GO:0000098)4.45705774
25cell adhesion mediated by integrin (GO:0033627)4.39775140
26high-density lipoprotein particle remodeling (GO:0034375)4.29334437
27regulation of protein activation cascade (GO:2000257)4.27802283
28fibrinolysis (GO:0042730)4.24651795
29intermediate filament organization (GO:0045109)4.24463798
30kynurenine metabolic process (GO:0070189)4.19208837
31alpha-linolenic acid metabolic process (GO:0036109)4.15824753
32water homeostasis (GO:0030104)4.15775273
33bile acid biosynthetic process (GO:0006699)4.15471065
34chemical homeostasis within a tissue (GO:0048875)4.14998571
35cysteine metabolic process (GO:0006534)4.13438336
36glyoxylate metabolic process (GO:0046487)4.10881391
37nitrogen cycle metabolic process (GO:0071941)4.06942861
38indole-containing compound catabolic process (GO:0042436)4.06469955
39indolalkylamine catabolic process (GO:0046218)4.06469955
40tryptophan catabolic process (GO:0006569)4.06469955
41complement activation, alternative pathway (GO:0006957)4.04168047
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.03894964
43regulation of complement activation (GO:0030449)4.03524816
44epidermis development (GO:0008544)3.96506905
45tryptophan metabolic process (GO:0006568)3.86119789
46plasma lipoprotein particle clearance (GO:0034381)3.85642349
47regulation of keratinocyte proliferation (GO:0010837)3.85367908
48reverse cholesterol transport (GO:0043691)3.83976678
49keratinocyte differentiation (GO:0030216)3.83077189
50phospholipid efflux (GO:0033700)3.81747719
51regulation of triglyceride catabolic process (GO:0010896)3.72272565
52homocysteine metabolic process (GO:0050667)3.68631310
53negative regulation of cholesterol transport (GO:0032375)3.65147981
54negative regulation of sterol transport (GO:0032372)3.65147981
55gonadal mesoderm development (GO:0007506)3.63915595
56protein localization to endosome (GO:0036010)3.62646359
57bile acid metabolic process (GO:0008206)3.60409448
58cellular glucuronidation (GO:0052695)3.60212769
59regulation of cholesterol homeostasis (GO:2000188)3.60149335
60plasma lipoprotein particle remodeling (GO:0034369)3.58544741
61protein-lipid complex remodeling (GO:0034368)3.58544741
62macromolecular complex remodeling (GO:0034367)3.58544741
63positive regulation of epidermal cell differentiation (GO:0045606)3.58504284
64amino-acid betaine metabolic process (GO:0006577)3.56828416
65polarized epithelial cell differentiation (GO:0030859)3.52974708
66establishment of tissue polarity (GO:0007164)3.52969101
67establishment of planar polarity (GO:0001736)3.52969101
68regulation of cholesterol esterification (GO:0010872)3.52208644
69Golgi transport vesicle coating (GO:0048200)3.49662508
70COPI coating of Golgi vesicle (GO:0048205)3.49662508
71serine family amino acid catabolic process (GO:0009071)3.47624493
72positive regulation of epidermis development (GO:0045684)3.46328415
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44090473
74endodermal cell differentiation (GO:0035987)3.40746393
75triglyceride homeostasis (GO:0070328)3.40112266
76acylglycerol homeostasis (GO:0055090)3.40112266
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.38324041
78regulation of hair follicle development (GO:0051797)3.37770514
79skin morphogenesis (GO:0043589)3.37215524
80epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36426476
81negative regulation of lipase activity (GO:0060192)3.34677230
82cholesterol efflux (GO:0033344)3.34169192
83epoxygenase P450 pathway (GO:0019373)3.33648516
84bile acid and bile salt transport (GO:0015721)3.29217568
85tyrosine metabolic process (GO:0006570)3.28466410
86planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27121671
87primary alcohol catabolic process (GO:0034310)3.25163354
88aromatic amino acid family metabolic process (GO:0009072)3.23967115
89keratinocyte development (GO:0003334)3.23915063
90glucuronate metabolic process (GO:0019585)3.22331126
91uronic acid metabolic process (GO:0006063)3.22331126
92ethanol oxidation (GO:0006069)3.20554993
93glycine metabolic process (GO:0006544)3.19283308
94epithelial cell-cell adhesion (GO:0090136)3.18984399
95mesodermal cell differentiation (GO:0048333)3.18599437
96positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.18366123
97plasma lipoprotein particle assembly (GO:0034377)3.15126903
98cholesterol homeostasis (GO:0042632)3.14885004
99complement activation (GO:0006956)3.13222531
100sterol homeostasis (GO:0055092)3.12066813
101lysine metabolic process (GO:0006553)3.11348981
102lysine catabolic process (GO:0006554)3.11348981
103response to nitrosative stress (GO:0051409)3.11062402
104positive regulation of lipid catabolic process (GO:0050996)3.10854689
105complement activation, classical pathway (GO:0006958)3.10517865
106benzene-containing compound metabolic process (GO:0042537)3.10446671
107acute-phase response (GO:0006953)3.08422167
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.06687416
109regulation of plasminogen activation (GO:0010755)3.05202014
110midgut development (GO:0007494)3.04926741
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04864149
112aldehyde catabolic process (GO:0046185)3.04088341
113imidazole-containing compound metabolic process (GO:0052803)3.03784422
114ethanol metabolic process (GO:0006067)3.03050967
115very-low-density lipoprotein particle assembly (GO:0034379)3.02712958
116protein-lipid complex assembly (GO:0065005)3.02011129
117protein activation cascade (GO:0072376)3.01420900
118arginine metabolic process (GO:0006525)3.00473912
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00013743
120epidermal cell differentiation (GO:0009913)2.98986974
121positive regulation of fatty acid biosynthetic process (GO:0045723)2.98742835
122alpha-amino acid catabolic process (GO:1901606)2.97049905
123negative regulation of chondrocyte differentiation (GO:0032331)2.97023275
124cellular modified amino acid catabolic process (GO:0042219)2.96882311
1254-hydroxyproline metabolic process (GO:0019471)2.95446660
126peptide cross-linking (GO:0018149)2.95085624
127low-density lipoprotein particle clearance (GO:0034383)2.95066168
128positive regulation of triglyceride lipase activity (GO:0061365)2.95038781
129positive regulation of lipoprotein lipase activity (GO:0051006)2.95038781
130regulation of transforming growth factor beta2 production (GO:0032909)2.93338259
131negative regulation of hemostasis (GO:1900047)2.92783429
132negative regulation of blood coagulation (GO:0030195)2.92783429
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92753620
134serine family amino acid metabolic process (GO:0009069)2.92641900
135regulation of endothelial cell chemotaxis (GO:2001026)2.92155441
136phospholipid homeostasis (GO:0055091)2.89066223
137* lipoprotein metabolic process (GO:0042157)2.86597480
138molting cycle (GO:0042303)2.86320593
139hair cycle (GO:0042633)2.86320593
140positive regulation of hemostasis (GO:1900048)2.84689270
141positive regulation of blood coagulation (GO:0030194)2.84689270
142cell junction assembly (GO:0034329)2.83609867
143positive regulation of keratinocyte differentiation (GO:0045618)2.83071969
144regulation of keratinocyte differentiation (GO:0045616)2.82655504
145hypotonic response (GO:0006971)2.82363710
146ectoderm development (GO:0007398)2.79501951
147renal filtration (GO:0097205)2.79469037
148regulation of epidermis development (GO:0045682)2.77940260
149regulation of cholesterol biosynthetic process (GO:0045540)2.75162437
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.74806331
151protein retention in ER lumen (GO:0006621)2.74245594
152focal adhesion assembly (GO:0048041)2.74166316
153cell-substrate adherens junction assembly (GO:0007045)2.74166316
154cell junction organization (GO:0034330)2.71770372
155positive regulation of hair follicle development (GO:0051798)2.71012454
156positive regulation of hair cycle (GO:0042635)2.71012454
157exogenous drug catabolic process (GO:0042738)2.70691503
158L-serine transport (GO:0015825)2.69039911
159atrioventricular valve morphogenesis (GO:0003181)2.68715409
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66846072
161branching involved in mammary gland duct morphogenesis (GO:0060444)2.66775382
162intermediate filament cytoskeleton organization (GO:0045104)2.64861974
163semaphorin-plexin signaling pathway (GO:0071526)2.64649371
164intestinal epithelial cell development (GO:0060576)2.63870681
165adherens junction assembly (GO:0034333)2.58662392
166skin development (GO:0043588)2.54863833
167intermediate filament-based process (GO:0045103)2.52474859
168basement membrane organization (GO:0071711)2.52420320
169drug catabolic process (GO:0042737)2.51846429
170intestinal cholesterol absorption (GO:0030299)2.51593488
171proline metabolic process (GO:0006560)2.50626500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.50222388
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.51297945
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.36160631
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.83513707
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.53328288
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.22814798
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01254253
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94868273
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.10230630
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96076315
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.94183393
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.81959359
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66921456
14CLOCK_20551151_ChIP-Seq_293T_Human2.62431505
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10348451
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.09125475
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02203903
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99647134
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.90794759
20* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88357033
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81913877
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77318056
23ZNF263_19887448_ChIP-Seq_K562_Human1.75484697
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66974287
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64949739
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64949739
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.64683245
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62678159
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61063321
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60537153
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60292006
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56850145
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53915553
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.53176141
35GATA4_25053715_ChIP-Seq_YYC3_Human1.49904700
36* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49837830
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48931575
38* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47571436
39* SOX2_20726797_ChIP-Seq_SW620_Human1.45864410
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44013416
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40852036
42RACK7_27058665_Chip-Seq_MCF-7_Human1.39052395
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38792834
44ATF3_27146783_Chip-Seq_COLON_Human1.34886648
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.31979461
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31596241
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27200107
48* TP63_22573176_ChIP-Seq_HFKS_Human1.26562040
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24502606
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24463370
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22549573
52* GATA6_25053715_ChIP-Seq_YYC3_Human1.22444414
53CJUN_26792858_Chip-Seq_BT549_Human1.22404972
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20534196
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19141045
56* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18256468
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10438473
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10206819
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09861788
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.08762536
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.08646209
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06183238
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05909650
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.02968291
65LXR_22292898_ChIP-Seq_THP-1_Human1.02394327
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01745928
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99952322
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99952322
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98875310
70TCF4_18268006_ChIP-ChIP_LS174T_Human0.98617688
71TP53_22127205_ChIP-Seq_IMR90_Human0.98490860
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96689850
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93707394
74RUNX1_27514584_Chip-Seq_MCF-7_Human0.92345684
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91488321
76* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91209442
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90424885
78* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89735733
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89359025
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88167558
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87470471
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.86694078
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85906208
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85605551
85TP53_18474530_ChIP-ChIP_U2OS_Human0.85544922
86* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85202928
87* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84425749
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84251580
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84009755
90GATA1_22025678_ChIP-Seq_K562_Human0.83324830
91EGR1_19374776_ChIP-ChIP_THP-1_Human0.83289538
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82906363
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81954204
94* TBX20_22328084_ChIP-Seq_HEART_Mouse0.80778830
95* TBX20_22080862_ChIP-Seq_HEART_Mouse0.80778830
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.80578035
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80406164
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80318768
99EGR1_19032775_ChIP-ChIP_M12_Human0.79955762
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79718891
101* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79322983
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78931170
103* KDM2B_26808549_Chip-Seq_K562_Human0.78308798
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77371093
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77008773
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76621188
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76578358
108AR_21909140_ChIP-Seq_LNCAP_Human0.76570407
109* TP63_23658742_ChIP-Seq_EP156T_Human0.76546083
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.76351527
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75957917
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75310369
113SMC4_20622854_ChIP-Seq_HELA_Human0.75026847
114AHR_22903824_ChIP-Seq_MCF-7_Human0.74595647
115* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74026092
116CREB1_26743006_Chip-Seq_LNCaP_Human0.73894161
117CHD1_26751641_Chip-Seq_LNCaP_Human0.72535713
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72492811
119KLF5_25053715_ChIP-Seq_YYC3_Human0.71203079
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71117062
121* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70498092
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69104870
123* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68436628
124BRD4_25478319_ChIP-Seq_HGPS_Human0.68191266
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66883828
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.65296937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.88871564
2MP0005360_urolithiasis4.44732734
3MP0005085_abnormal_gallbladder_physiolo3.87789273
4MP0003705_abnormal_hypodermis_morpholog3.82091406
5MP0005365_abnormal_bile_salt3.52498946
6MP0005275_abnormal_skin_tensile3.16670447
7MP0010234_abnormal_vibrissa_follicle3.16334504
8MP0008875_abnormal_xenobiotic_pharmacok3.06719106
9MP0002796_impaired_skin_barrier2.88161451
10MP0003252_abnormal_bile_duct2.46066231
11MP0005083_abnormal_biliary_tract2.42603929
12MP0003806_abnormal_nucleotide_metabolis2.39201868
13MP0005409_darkened_coat_color2.38190877
14MP0008438_abnormal_cutaneous_collagen2.36394106
15MP0009840_abnormal_foam_cell2.31314395
16MP0002060_abnormal_skin_morphology2.26466539
17MP0002254_reproductive_system_inflammat2.21328834
18MP0010329_abnormal_lipoprotein_level2.19366296
19MP0000579_abnormal_nail_morphology2.16428625
20MP0003453_abnormal_keratinocyte_physiol1.96583139
21MP0009053_abnormal_anal_canal1.93838471
22MP0001666_abnormal_nutrient_absorption1.92819852
23MP0003191_abnormal_cellular_cholesterol1.91660007
24MP0005501_abnormal_skin_physiology1.80815264
25MP0003566_abnormal_cell_adhesion1.78544005
26MP0003195_calcinosis1.70639246
27MP0002098_abnormal_vibrissa_morphology1.67252578
28MP0001216_abnormal_epidermal_layer1.60482592
29MP0010678_abnormal_skin_adnexa1.58831971
30MP0004019_abnormal_vitamin_homeostasis1.55043570
31MP0004782_abnormal_surfactant_physiolog1.50849382
32MP0010352_gastrointestinal_tract_polyps1.50047947
33MP0000678_abnormal_parathyroid_gland1.46580207
34MP0000383_abnormal_hair_follicle1.44369118
35MP0004272_abnormal_basement_membrane1.41216944
36MP0009384_cardiac_valve_regurgitation1.40624507
37* MP0005023_abnormal_wound_healing1.40023141
38MP0002138_abnormal_hepatobiliary_system1.39154894
39MP0000609_abnormal_liver_physiology1.36844920
40MP0000647_abnormal_sebaceous_gland1.35149405
41MP0000377_abnormal_hair_follicle1.35008270
42MP0004947_skin_inflammation1.33751439
43MP0005332_abnormal_amino_acid1.33666887
44MP0000467_abnormal_esophagus_morphology1.30189024
45MP0000537_abnormal_urethra_morphology1.26815645
46MP0008260_abnormal_autophagy1.26706256
47MP0010771_integument_phenotype1.25627822
48MP0001243_abnormal_dermal_layer1.23021501
49MP0010368_abnormal_lymphatic_system1.22760936
50MP0006054_spinal_hemorrhage1.21273510
51MP0000427_abnormal_hair_cycle1.19083794
52MP0003941_abnormal_skin_development1.17825920
53MP0001849_ear_inflammation1.16296849
54MP0002118_abnormal_lipid_homeostasis1.15426795
55MP0000566_synostosis1.12822056
56MP0003315_abnormal_perineum_morphology1.10383145
57MP0003011_delayed_dark_adaptation1.10120040
58MP0009780_abnormal_chondrocyte_physiolo1.10095276
59MP0005451_abnormal_body_composition1.08723863
60MP0001958_emphysema1.08070117
61MP0010030_abnormal_orbit_morphology1.06880395
62MP0002089_abnormal_postnatal_growth/wei1.05211204
63MP0000762_abnormal_tongue_morphology1.04869096
64MP0005319_abnormal_enzyme/_coenzyme1.04820293
65MP0004264_abnormal_extraembryonic_tissu1.04663561
66MP0000858_altered_metastatic_potential1.00042962
67MP0009931_abnormal_skin_appearance0.93980542
68MP0004381_abnormal_hair_follicle0.91637126
69MP0002282_abnormal_trachea_morphology0.89475158
70MP0003186_abnormal_redox_activity0.88082904
71MP0002295_abnormal_pulmonary_circulatio0.88052909
72MP0003436_decreased_susceptibility_to0.86961369
73MP0005248_abnormal_Harderian_gland0.86880949
74MP0005503_abnormal_tendon_morphology0.85094616
75MP0003950_abnormal_plasma_membrane0.85042868
76MP0003279_aneurysm0.83856266
77MP0005257_abnormal_intraocular_pressure0.83752106
78MP0003300_gastrointestinal_ulcer0.81812136
79MP0003868_abnormal_feces_composition0.80583232
80MP0001191_abnormal_skin_condition0.80223412
81MP0009379_abnormal_foot_pigmentation0.77180120
82MP0005408_hypopigmentation0.76852421
83MP0009764_decreased_sensitivity_to0.76723112
84MP0009643_abnormal_urine_homeostasis0.76663266
85MP0000598_abnormal_liver_morphology0.75908655
86MP0004858_abnormal_nervous_system0.73105880
87MP0004185_abnormal_adipocyte_glucose0.71508285
88MP0000462_abnormal_digestive_system0.71343306
89MP0001661_extended_life_span0.70642631
90MP0000003_abnormal_adipose_tissue0.68852433
91MP0005076_abnormal_cell_differentiation0.68711203
92MP0003755_abnormal_palate_morphology0.68280332
93MP0009763_increased_sensitivity_to0.65734522
94MP0002896_abnormal_bone_mineralization0.65513785
95MP0002234_abnormal_pharynx_morphology0.65470377
96MP0008004_abnormal_stomach_pH0.64581270
97MP0002877_abnormal_melanocyte_morpholog0.64248008
98MP0000538_abnormal_urinary_bladder0.63214578
99MP0000367_abnormal_coat/_hair0.63106120
100MP0001346_abnormal_lacrimal_gland0.62725900
101MP0005647_abnormal_sex_gland0.61484308
102MP0001542_abnormal_bone_strength0.61298883
103MP0001340_abnormal_eyelid_morphology0.60435402
104MP0005508_abnormal_skeleton_morphology0.60362610
105MP0005197_abnormal_uvea_morphology0.59982333
106MP0002697_abnormal_eye_size0.59830886
107* MP0000627_abnormal_mammary_gland0.59696940
108MP0009697_abnormal_copulation0.59244092
109MP0003091_abnormal_cell_migration0.58540614
110MP0005584_abnormal_enzyme/coenzyme_acti0.58501916
111MP0005220_abnormal_exocrine_pancreas0.58034737
112MP0001533_abnormal_skeleton_physiology0.56098105
113MP0002168_other_aberrant_phenotype0.55718010
114MP0003115_abnormal_respiratory_system0.53968425
115MP0001851_eye_inflammation0.53939221
116MP0000604_amyloidosis0.53737532
117MP0001881_abnormal_mammary_gland0.53650823
118MP0001299_abnormal_eye_distance/0.52610092
119MP0002111_abnormal_tail_morphology0.52283235
120MP0005193_abnormal_anterior_eye0.52132932
121MP0003329_amyloid_beta_deposits0.48889452
122MP0005164_abnormal_response_to0.48266229
123MP0005623_abnormal_meninges_morphology0.48107115
124MP0008789_abnormal_olfactory_epithelium0.47135781
125MP0005058_abnormal_lysosome_morphology0.46437251
126MP0001915_intracranial_hemorrhage0.45815730
127MP0000013_abnormal_adipose_tissue0.44773240
128MP0006138_congestive_heart_failure0.42555971
129MP0005375_adipose_tissue_phenotype0.42116104

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.81730567
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.23122296
3Intrahepatic cholestasis (HP:0001406)5.17152676
4Xanthomatosis (HP:0000991)5.08154097
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42471275
6Ridged nail (HP:0001807)4.32954790
7Hypobetalipoproteinemia (HP:0003563)4.30589018
8Onycholysis (HP:0001806)4.24819456
9Right ventricular cardiomyopathy (HP:0011663)4.05637321
10Prolonged partial thromboplastin time (HP:0003645)4.04369645
11Atrophic scars (HP:0001075)3.93502600
12Hyperlipoproteinemia (HP:0010980)3.71191452
13Fragile nails (HP:0001808)3.70604083
14Epidermoid cyst (HP:0200040)3.65022923
15Complement deficiency (HP:0004431)3.60561423
16Hypolipoproteinemia (HP:0010981)3.58731193
17Plantar hyperkeratosis (HP:0007556)3.49510128
18Milia (HP:0001056)3.46102227
19Protrusio acetabuli (HP:0003179)3.45288887
20Hypoalphalipoproteinemia (HP:0003233)3.45238548
21Abnormality of the common coagulation pathway (HP:0010990)3.44480777
22Hypoplasia of dental enamel (HP:0006297)3.26873399
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25185764
24Pterygium (HP:0001059)3.24781714
25Alopecia of scalp (HP:0002293)3.13510711
26Premature rupture of membranes (HP:0001788)3.13347090
27Selective tooth agenesis (HP:0001592)3.12744750
28Sparse eyelashes (HP:0000653)3.11682957
29Myocardial infarction (HP:0001658)3.08817031
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07333686
31Abnormality of complement system (HP:0005339)3.03738502
32Joint hemorrhage (HP:0005261)2.99593297
33Peritonitis (HP:0002586)2.96885456
34Woolly hair (HP:0002224)2.92849255
35Cardiovascular calcification (HP:0011915)2.89373829
36Vascular calcification (HP:0004934)2.86460643
37Fat malabsorption (HP:0002630)2.85231899
38Hypotrichosis (HP:0001006)2.81782436
39Sparse scalp hair (HP:0002209)2.75121865
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.71809632
41Oral leukoplakia (HP:0002745)2.70847663
42Lip pit (HP:0100267)2.69976840
43Abnormality of the intrinsic pathway (HP:0010989)2.69749661
44Hyperammonemia (HP:0001987)2.69314656
45Absent eyelashes (HP:0000561)2.68294408
46Ankyloglossia (HP:0010296)2.61366567
47Hypercholesterolemia (HP:0003124)2.59126665
48Abnormality of nail color (HP:0100643)2.58038273
49Interstitial pulmonary disease (HP:0006530)2.57317216
50Dry hair (HP:0011359)2.55988881
51Palmoplantar hyperkeratosis (HP:0000972)2.50638108
52Abnormality of the axillary hair (HP:0100134)2.50509891
53Abnormality of secondary sexual hair (HP:0009888)2.50509891
54Abnormality of the salivary glands (HP:0010286)2.49127121
55Abnormality of methionine metabolism (HP:0010901)2.48686702
56Hepatocellular carcinoma (HP:0001402)2.48302841
57Nail dystrophy (HP:0008404)2.46829504
58Erythema (HP:0010783)2.46290048
59Esophageal varix (HP:0002040)2.45258251
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43115331
61Corneal erosion (HP:0200020)2.38647157
62Popliteal pterygium (HP:0009756)2.36921730
63Thick nail (HP:0001805)2.36806198
64Abnormality of pyrimidine metabolism (HP:0004353)2.33138822
65Flat acetabular roof (HP:0003180)2.32522849
66Congenital ichthyosiform erythroderma (HP:0007431)2.31628906
67Palmar hyperkeratosis (HP:0010765)2.30352677
68Fragile skin (HP:0001030)2.27179323
69Anonychia (HP:0001798)2.25807868
70Spastic diplegia (HP:0001264)2.22622658
71Aplasia cutis congenita (HP:0001057)2.22246672
72Pili torti (HP:0003777)2.19700276
73Abnormal cartilage morphology (HP:0002763)2.18345513
74Abnormality of the Achilles tendon (HP:0005109)2.17537775
75Short nail (HP:0001799)2.16009508
76Abnormality of oral frenula (HP:0000190)2.14846399
77Follicular hyperkeratosis (HP:0007502)2.14138307
78Skin nodule (HP:0200036)2.13010880
79Steatorrhea (HP:0002570)2.12445515
80Malnutrition (HP:0004395)2.11788255
81Mitral stenosis (HP:0001718)2.11486971
82Palmoplantar keratoderma (HP:0000982)2.09757191
83Oligodontia (HP:0000677)2.09531162
84Hypoplastic labia majora (HP:0000059)2.08446361
85Blepharitis (HP:0000498)2.07988653
86Amniotic constriction ring (HP:0009775)2.07005863
87Abnormality of placental membranes (HP:0011409)2.07005863
88Abnormal blistering of the skin (HP:0008066)2.06863979
89Hyperglycinemia (HP:0002154)2.06206136
90Hypoglycemic coma (HP:0001325)2.02671309
91Abnormality of nucleobase metabolism (HP:0010932)2.02089559
92Ketosis (HP:0001946)2.01550657
93Amyloidosis (HP:0011034)1.98220667
94Conjugated hyperbilirubinemia (HP:0002908)1.97699210
95Spontaneous abortion (HP:0005268)1.96829188
96Osteolytic defects of the hand bones (HP:0009699)1.94960478
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.94960478
98Carious teeth (HP:0000670)1.93274993
99Abnormality of carpal bone ossification (HP:0006257)1.90834656
100Abnormal hair laboratory examination (HP:0003328)1.90378997
101Abnormality of the distal phalanges of the toes (HP:0010182)1.90307533
102Nephritis (HP:0000123)1.90077787
103Shallow orbits (HP:0000586)1.89949478
104Acanthosis nigricans (HP:0000956)1.89314471
105Hypodontia (HP:0000668)1.87045719
106Hyperglycinuria (HP:0003108)1.86980555
107Increased connective tissue (HP:0009025)1.86636430
108Abnormality of purine metabolism (HP:0004352)1.86564927
109Ectopia lentis (HP:0001083)1.86043501
110Abnormality of glycine metabolism (HP:0010895)1.85882422
111Abnormality of serine family amino acid metabolism (HP:0010894)1.85882422
112Abnormality of the gastric mucosa (HP:0004295)1.84482982
113Abnormal hemoglobin (HP:0011902)1.84449059
114Hyperhidrosis (HP:0000975)1.83765425
115Cervical subluxation (HP:0003308)1.83764304
116Increased mean platelet volume (HP:0011877)1.83618110
117Abnormality of the labia majora (HP:0012881)1.82518539
118Back pain (HP:0003418)1.81907278
119Abnormal delivery (HP:0001787)1.81210590
120Arterial tortuosity (HP:0005116)1.80982007
121Hemorrhage of the eye (HP:0011885)1.80766521
122Neonatal onset (HP:0003623)1.80468141
123Mitral valve prolapse (HP:0001634)1.80307640
124Neonatal death (HP:0003811)1.79812291
125Septate vagina (HP:0001153)1.79697331
126Erythroderma (HP:0001019)1.79486680
127Turricephaly (HP:0000262)1.79408034
128Ankle contracture (HP:0006466)1.79346217
129Gout (HP:0001997)1.78995424
130Ectropion (HP:0000656)1.78970409
131Fatigable weakness (HP:0003473)1.76933222
132Abnormality of the neuromuscular junction (HP:0003398)1.76933222
133Breast hypoplasia (HP:0003187)1.76036458
134Nasolacrimal duct obstruction (HP:0000579)1.75662476
135Ulnar bowing (HP:0003031)1.75318577
136Systemic lupus erythematosus (HP:0002725)1.75307266
137Broad face (HP:0000283)1.74220698
138Abnormality of proline metabolism (HP:0010907)1.74153691
139Hydroxyprolinuria (HP:0003080)1.74153691
140Glomerulonephritis (HP:0000099)1.74063626
141Focal segmental glomerulosclerosis (HP:0000097)1.73771260
142Rickets (HP:0002748)1.73518338
143Pustule (HP:0200039)1.73510494
144Hyperbilirubinemia (HP:0002904)1.72266825
145Achilles tendon contracture (HP:0001771)1.71749108
146Natal tooth (HP:0000695)1.71702985
147Respiratory distress (HP:0002098)1.70482035
148Dehydration (HP:0001944)1.70412350
149Amelogenesis imperfecta (HP:0000705)1.70069436
150Advanced eruption of teeth (HP:0006288)1.69587073
151Menorrhagia (HP:0000132)1.69260596
152Trismus (HP:0000211)1.68386709
153Abnormality of the fingernails (HP:0001231)1.67432560
154Abnormality of permanent molar morphology (HP:0011071)1.65893718
155Abnormality of the dental root (HP:0006486)1.65893718
156Taurodontia (HP:0000679)1.65893718
157Laryngomalacia (HP:0001601)1.62769181
158Abnormal ossification of hand bones (HP:0005921)1.62281914
159Neurofibrillary tangles (HP:0002185)1.57146058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.22136645
2EPHA23.78661367
3MST1R3.23775569
4LATS13.10079002
5TRIB33.06407887
6FGFR42.76184653
7SIK12.61457063
8ARAF2.60006325
9PKN22.55447724
10EPHB22.45897928
11MAP3K32.22014698
12FER2.19716637
13PTK62.09941636
14NTRK12.07176022
15BCKDK1.99795914
16LMTK21.97059691
17FRK1.86934383
18SMG11.85188801
19LRRK21.81494611
20IRAK31.78737622
21MET1.78611686
22LATS21.74853015
23DDR21.66158700
24RIPK11.63501370
25MAPKAPK31.57952706
26PDGFRA1.57503024
27TTN1.55102055
28NEK91.52013018
29PTK21.51354690
30ERBB41.48949022
31EPHA31.44460941
32RPS6KA41.42275623
33EPHB11.42043231
34FLT31.41489189
35CDK61.37332606
36MAP3K91.34978243
37FGFR21.31650902
38ICK1.28311486
39STK101.24421922
40PIK3CG1.21097209
41TRPM71.20814564
42MAP3K101.20396013
43TYK21.20208961
44RPS6KB21.19864974
45CDK121.19281666
46STK31.18897188
47PAK41.18765494
48TBK11.18402253
49TGFBR21.17122166
50BMX1.16344020
51MAP3K61.15723690
52MAP3K21.13033881
53MST41.09343379
54STK38L1.08533599
55TESK11.06821080
56MAP2K21.01344387
57ERBB20.99677964
58EEF2K0.97467146
59PRPF4B0.96689327
60ABL20.95719019
61MAP2K10.95162905
62TAOK30.90670837
63MAP2K30.89836068
64MAP3K110.84635028
65MAP3K120.83757597
66FGFR10.83422862
67NME20.81892901
68DYRK1B0.81473838
69BRAF0.79441664
70FGFR30.77643294
71PAK20.75975682
72RPS6KA20.75884215
73PIM20.75645367
74PRKCI0.73591707
75MAPK110.73238209
76PBK0.70452327
77TGFBR10.69316278
78STK380.68551751
79MAP3K80.65914544
80PDGFRB0.65034864
81PRKD20.61351064
82MAP3K140.60786313
83GSK3A0.59809732
84STK240.57849416
85ERBB30.57486229
86MTOR0.57053526
87SCYL20.54415101
88MYLK0.54388514
89KDR0.53951515
90JAK10.53707099
91CDC42BPA0.52810457
92MAP3K10.51656458
93LIMK10.51455233
94TAOK10.49621779
95CHUK0.48780148
96ROCK20.48760431
97CSK0.47034025
98MOS0.44537548
99JAK20.44511364
100PRKG20.43173972
101MAP3K70.43011432
102PAK30.42388292
103RAF10.41094039
104MAP3K130.40188852
105EGFR0.40158968
106PRKD10.39750920
107IKBKE0.39417592
108ABL10.37893852
109MATK0.37503471
110RET0.37141473
111ILK0.36793041
112KSR20.31480833
113MAPKAPK20.31086361
114JAK30.30810393
115KIT0.30430087
116IGF1R0.30269438
117CAMK2G0.28536596
118PDPK10.28325543
119PIK3CA0.28112105
120RPS6KC10.27447387
121RPS6KL10.27447387
122ROCK10.26952743
123ZAP700.26609009
124CSF1R0.26096681
125TAOK20.25943817
126MAPK150.25789722
127CDK70.24816828
128SRC0.24283910
129NEK60.22034885
130NEK10.21632367
131RPS6KA10.19071258
132RPS6KB10.18245250
133AKT20.16684016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00368431
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44920303
3Nitrogen metabolism_Homo sapiens_hsa009103.14000698
4Complement and coagulation cascades_Homo sapiens_hsa046102.84452891
5Arginine biosynthesis_Homo sapiens_hsa002202.79609480
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78413843
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.39118329
8Tryptophan metabolism_Homo sapiens_hsa003802.33539412
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.32601481
10Chemical carcinogenesis_Homo sapiens_hsa052042.30566854
11Fatty acid degradation_Homo sapiens_hsa000712.30036766
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28695592
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14307390
14Caffeine metabolism_Homo sapiens_hsa002322.04689725
15Histidine metabolism_Homo sapiens_hsa003402.04033711
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03765472
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98125298
18Staphylococcus aureus infection_Homo sapiens_hsa051501.90140943
19Retinol metabolism_Homo sapiens_hsa008301.85319957
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.83595483
21PPAR signaling pathway_Homo sapiens_hsa033201.83388293
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72627568
23Phenylalanine metabolism_Homo sapiens_hsa003601.70930769
24Peroxisome_Homo sapiens_hsa041461.69600888
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.57220387
26Selenocompound metabolism_Homo sapiens_hsa004501.51430748
27beta-Alanine metabolism_Homo sapiens_hsa004101.50418487
28Fatty acid metabolism_Homo sapiens_hsa012121.50293975
29Fat digestion and absorption_Homo sapiens_hsa049751.39929065
30Tyrosine metabolism_Homo sapiens_hsa003501.35096098
31Bile secretion_Homo sapiens_hsa049761.34169166
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32132354
33Butanoate metabolism_Homo sapiens_hsa006501.29310778
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.28585951
35Sphingolipid metabolism_Homo sapiens_hsa006001.24061020
36Sulfur metabolism_Homo sapiens_hsa009201.22455170
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19927554
38Starch and sucrose metabolism_Homo sapiens_hsa005001.19247006
39Steroid biosynthesis_Homo sapiens_hsa001001.18386277
40Fructose and mannose metabolism_Homo sapiens_hsa000511.18155620
41Folate biosynthesis_Homo sapiens_hsa007901.17473167
42N-Glycan biosynthesis_Homo sapiens_hsa005101.16824800
43Vitamin B6 metabolism_Homo sapiens_hsa007501.14183645
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12026306
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11082369
46Propanoate metabolism_Homo sapiens_hsa006401.08763759
47Glutathione metabolism_Homo sapiens_hsa004801.06392723
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05254671
49Fatty acid elongation_Homo sapiens_hsa000621.04635716
50Biosynthesis of amino acids_Homo sapiens_hsa012301.00641409
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96803785
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.96147908
53ABC transporters_Homo sapiens_hsa020100.94420370
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91836156
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91444881
56* ECM-receptor interaction_Homo sapiens_hsa045120.91408805
57Sulfur relay system_Homo sapiens_hsa041220.87424917
58Bladder cancer_Homo sapiens_hsa052190.86648047
59Arginine and proline metabolism_Homo sapiens_hsa003300.86474061
60Carbon metabolism_Homo sapiens_hsa012000.83603623
61Pyruvate metabolism_Homo sapiens_hsa006200.83487521
62Other glycan degradation_Homo sapiens_hsa005110.83368806
63Vitamin digestion and absorption_Homo sapiens_hsa049770.79053113
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76710533
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76633011
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75219068
67Chronic myeloid leukemia_Homo sapiens_hsa052200.74272077
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.70264376
69Notch signaling pathway_Homo sapiens_hsa043300.68683858
70ErbB signaling pathway_Homo sapiens_hsa040120.65757982
71Lysine degradation_Homo sapiens_hsa003100.64951345
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64511721
73p53 signaling pathway_Homo sapiens_hsa041150.64270338
74One carbon pool by folate_Homo sapiens_hsa006700.63559324
75Axon guidance_Homo sapiens_hsa043600.62660920
76Amoebiasis_Homo sapiens_hsa051460.62259423
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61748800
78Pancreatic cancer_Homo sapiens_hsa052120.61733916
79Adherens junction_Homo sapiens_hsa045200.61397675
80Pentose phosphate pathway_Homo sapiens_hsa000300.60679817
81Fatty acid biosynthesis_Homo sapiens_hsa000610.59896127
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59381169
83VEGF signaling pathway_Homo sapiens_hsa043700.59089008
84Endometrial cancer_Homo sapiens_hsa052130.56720530
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55084831
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55050869
87Insulin signaling pathway_Homo sapiens_hsa049100.54355787
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53011351
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52531736
90Small cell lung cancer_Homo sapiens_hsa052220.52410988
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.52064858
92* Proteoglycans in cancer_Homo sapiens_hsa052050.47286983
93Linoleic acid metabolism_Homo sapiens_hsa005910.47178698
94Basal cell carcinoma_Homo sapiens_hsa052170.46727382
95Glycerolipid metabolism_Homo sapiens_hsa005610.44957605
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43945163
97Focal adhesion_Homo sapiens_hsa045100.42556062
98Glioma_Homo sapiens_hsa052140.42296581
99Acute myeloid leukemia_Homo sapiens_hsa052210.40272586
100Renal cell carcinoma_Homo sapiens_hsa052110.39803814
101Hippo signaling pathway_Homo sapiens_hsa043900.36071746
102Insulin resistance_Homo sapiens_hsa049310.35029948
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.34097977
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31971812
105TGF-beta signaling pathway_Homo sapiens_hsa043500.30488501
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29929659
107Mineral absorption_Homo sapiens_hsa049780.29118699
108Pertussis_Homo sapiens_hsa051330.28062000
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.27324452
110Protein digestion and absorption_Homo sapiens_hsa049740.26084846
111Galactose metabolism_Homo sapiens_hsa000520.24120510
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23943209
113Prion diseases_Homo sapiens_hsa050200.23703077
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.23630614
115Thyroid cancer_Homo sapiens_hsa052160.23293919
116Legionellosis_Homo sapiens_hsa051340.23224470
117Toxoplasmosis_Homo sapiens_hsa051450.22955174
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21876796
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21841527
120Hepatitis C_Homo sapiens_hsa051600.20438710
121MicroRNAs in cancer_Homo sapiens_hsa052060.20397942
122Metabolic pathways_Homo sapiens_hsa011000.19486884
123Tight junction_Homo sapiens_hsa045300.17742729
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17558215
125Arachidonic acid metabolism_Homo sapiens_hsa005900.13967322

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