SCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.60850782
2primary alcohol catabolic process (GO:0034310)9.32529681
3exploration behavior (GO:0035640)8.94378718
4actin-myosin filament sliding (GO:0033275)8.51309038
5muscle filament sliding (GO:0030049)8.51309038
6ethanol metabolic process (GO:0006067)8.34071595
7regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)8.02875430
8positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)8.02875430
9skeletal muscle contraction (GO:0003009)7.23857693
10positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)7.20016383
11regulation of necrotic cell death (GO:0010939)7.14756706
12hepatocyte apoptotic process (GO:0097284)7.00882559
13actin-mediated cell contraction (GO:0070252)6.75455435
14intestinal epithelial cell development (GO:0060576)6.71557449
15proline metabolic process (GO:0006560)6.67978176
16endocrine pancreas development (GO:0031018)6.46932253
17regulation of respiratory burst (GO:0060263)6.38876111
18regulation of hydrogen peroxide metabolic process (GO:0010310)6.34762889
19regulation of MHC class I biosynthetic process (GO:0045343)6.32213258
20calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.31570065
21sarcoplasmic reticulum calcium ion transport (GO:0070296)6.25875486
22triglyceride homeostasis (GO:0070328)6.22090460
23acylglycerol homeostasis (GO:0055090)6.22090460
24cell differentiation involved in embryonic placenta development (GO:0060706)6.05905191
25positive regulation of glucose transport (GO:0010828)6.03395702
26purine deoxyribonucleotide catabolic process (GO:0009155)6.00720660
27regulation of skeletal muscle contraction (GO:0014819)5.88797755
28regulation of substrate adhesion-dependent cell spreading (GO:1900024)5.87592234
29regulation of cAMP-mediated signaling (GO:0043949)5.84050261
30phosphatidylglycerol biosynthetic process (GO:0006655)5.73227165
31natural killer cell activation involved in immune response (GO:0002323)5.67380209
32bundle of His cell to Purkinje myocyte communication (GO:0086069)5.32068614
33positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)5.26718384
34type I interferon signaling pathway (GO:0060337)5.24262300
35cellular response to type I interferon (GO:0071357)5.24262300
36response to type I interferon (GO:0034340)5.14854169
37actin filament-based movement (GO:0030048)5.11713304
38regulation of type I interferon-mediated signaling pathway (GO:0060338)5.08167361
39positive regulation of digestive system process (GO:0060456)5.07044619
40immunoglobulin mediated immune response (GO:0016064)5.03696805
41galactose catabolic process (GO:0019388)4.98321045
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.94908610
43positive regulation of protein homooligomerization (GO:0032464)4.71418607
44negative regulation of glial cell proliferation (GO:0060253)4.66701420
45glutamine family amino acid biosynthetic process (GO:0009084)4.64837768
46membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.61005270
47positive regulation of DNA-templated transcription, initiation (GO:2000144)4.59133468
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58171992
49trophectodermal cell differentiation (GO:0001829)4.53906640
50deoxyribonucleotide catabolic process (GO:0009264)4.49354560
51ventricular cardiac muscle cell action potential (GO:0086005)4.49007706
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.42818202
53striated muscle contraction (GO:0006941)4.39322191
54cellular response to exogenous dsRNA (GO:0071360)4.33540448
55regulation of dendritic cell antigen processing and presentation (GO:0002604)4.32220688
56skeletal muscle fiber development (GO:0048741)4.26596230
57cellular response to interferon-beta (GO:0035458)4.22562830
58lung secretory cell differentiation (GO:0061140)4.20642799
59potassium ion export (GO:0071435)4.19314531
60long-term synaptic potentiation (GO:0060291)4.18390970
61myofibril assembly (GO:0030239)4.13471153
62purine nucleotide salvage (GO:0032261)4.11824498
63positive regulation of insulin secretion (GO:0032024)4.11441737
64deoxyribose phosphate catabolic process (GO:0046386)4.07995389
65labyrinthine layer development (GO:0060711)4.07201993
66phosphatidylinositol acyl-chain remodeling (GO:0036149)4.06923676
67creatine metabolic process (GO:0006600)4.05181463
68defense response to protozoan (GO:0042832)4.04210422
69membrane repolarization during action potential (GO:0086011)4.00874700
70energy coupled proton transport, down electrochemical gradient (GO:0015985)4.00062433
71ATP synthesis coupled proton transport (GO:0015986)4.00062433
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98521664
73regulation of relaxation of muscle (GO:1901077)3.93869254
74negative regulation of myotube differentiation (GO:0010832)3.93163203
75positive regulation of antigen processing and presentation (GO:0002579)3.90025099
76cellular response to virus (GO:0098586)3.88109812
77antigen processing and presentation of endogenous antigen (GO:0019883)3.87645013
78mucosal-associated lymphoid tissue development (GO:0048537)3.84645832
79Peyers patch development (GO:0048541)3.84645832
80placenta development (GO:0001890)3.81502609
81positive regulation of interferon-alpha production (GO:0032727)3.81226821
82response to inactivity (GO:0014854)3.78968257
83positive thymic T cell selection (GO:0045059)3.78364807
84mitochondrial calcium ion transport (GO:0006851)3.74560637
85histamine secretion (GO:0001821)3.69959132
86intestinal absorption (GO:0050892)3.69211632
87phosphatidylserine acyl-chain remodeling (GO:0036150)3.67873344
88regulation of germinal center formation (GO:0002634)3.67650319
89positive regulation of myotube differentiation (GO:0010831)3.67602634
90GDP-mannose metabolic process (GO:0019673)3.67234567
91B cell mediated immunity (GO:0019724)3.66825850
92regulation of G0 to G1 transition (GO:0070316)3.65336792
93negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.64442755
94cardiovascular system development (GO:0072358)3.63966413
95response to axon injury (GO:0048678)3.62883865
96negative regulation of keratinocyte proliferation (GO:0010839)3.60230584
97response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.58457476
98interferon-gamma-mediated signaling pathway (GO:0060333)3.57668721
99negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)3.57472128
100low-density lipoprotein particle remodeling (GO:0034374)3.56519848
101purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.55854051
102myotube cell development (GO:0014904)3.55513120
103regulation of heart rate by cardiac conduction (GO:0086091)3.53608610
104atrial cardiac muscle cell action potential (GO:0086014)3.50683194
105response to protozoan (GO:0001562)3.49952650
106regulation of interferon-alpha production (GO:0032647)3.48777437
107negative regulation of growth of symbiont in host (GO:0044130)3.47210114
108negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.47210114
109modulation of growth of symbiont involved in interaction with host (GO:0044144)3.47210114
110regulation of growth of symbiont in host (GO:0044126)3.47210114
111keratinocyte development (GO:0003334)3.47060187
112sarcomere organization (GO:0045214)3.46982586
113glandular epithelial cell differentiation (GO:0002067)3.46300296
114regulation of penile erection (GO:0060405)3.45546267
115regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.41187745
116muscle cell fate commitment (GO:0042693)3.40697367
117decidualization (GO:0046697)3.40255858
118phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.38735284
119galactose metabolic process (GO:0006012)3.38684375
120UDP-N-acetylglucosamine metabolic process (GO:0006047)3.38546458
121pyrimidine-containing compound salvage (GO:0008655)3.36942529
122pyrimidine nucleoside salvage (GO:0043097)3.36942529
123NADH metabolic process (GO:0006734)3.36872393
124muscle contraction (GO:0006936)3.34496054
125L-serine transport (GO:0015825)3.33244544
126nucleotide salvage (GO:0043173)3.32419853
127response to muscle activity (GO:0014850)3.31420161
128bone morphogenesis (GO:0060349)3.30471298
129skeletal muscle tissue regeneration (GO:0043403)3.29720982
130skeletal muscle tissue development (GO:0007519)3.28873273
131positive regulation of peptide hormone secretion (GO:0090277)3.27466612
132negative regulation of B cell apoptotic process (GO:0002903)3.25636160
133phosphatidylserine metabolic process (GO:0006658)3.24156772
134negative thymic T cell selection (GO:0045060)3.23924222
135regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.23733923
136thymic T cell selection (GO:0045061)3.21726770
137Golgi transport vesicle coating (GO:0048200)3.17329604
138COPI coating of Golgi vesicle (GO:0048205)3.17329604
139regulation of hypersensitivity (GO:0002883)3.16447463
140desmosome organization (GO:0002934)3.16197676
141positive regulation of peptide secretion (GO:0002793)3.16045902
142cardiac conduction (GO:0061337)3.15884313
143positive regulation of gastrulation (GO:2000543)3.13886035
144growth hormone secretion (GO:0030252)3.13124311
145purine deoxyribonucleotide metabolic process (GO:0009151)3.10825832
146deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07249253
147plasma membrane repair (GO:0001778)3.07145611
148histamine transport (GO:0051608)3.05951175
1492-oxoglutarate metabolic process (GO:0006103)3.04017935
150muscle system process (GO:0003012)3.03307872
151mature B cell differentiation involved in immune response (GO:0002313)3.03305865
152regulation of phagocytosis (GO:0050764)3.02706753
153positive regulation of neutrophil chemotaxis (GO:0090023)2.98927621
154positive regulation of neutrophil migration (GO:1902624)2.98927621
155skeletal muscle adaptation (GO:0043501)2.92137984
156adenosine metabolic process (GO:0046085)2.91938514
157positive regulation of cellular response to insulin stimulus (GO:1900078)2.91478785
158response to host immune response (GO:0052572)2.91337596
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91337596
160tumor necrosis factor-mediated signaling pathway (GO:0033209)2.90933690
161establishment of viral latency (GO:0019043)2.90038035
162antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89694527
163response to interferon-beta (GO:0035456)2.89425137
164negative regulation of thymocyte apoptotic process (GO:0070244)2.88751816
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88626630
166negative regulation of smooth muscle cell differentiation (GO:0051151)2.88297456
167negative T cell selection (GO:0043383)2.87962046
168positive regulation of pseudopodium assembly (GO:0031274)2.86781645
169maintenance of gastrointestinal epithelium (GO:0030277)2.85744727
170phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.85226740
171negative regulation of type 2 immune response (GO:0002829)2.84860675
172chaperone mediated protein folding requiring cofactor (GO:0051085)2.84741559
173regulation of antigen processing and presentation (GO:0002577)2.84657042
174regulation of interferon-beta biosynthetic process (GO:0045357)2.84077604
175serine transport (GO:0032329)2.83592085
176regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83262270
177cellular response to epinephrine stimulus (GO:0071872)2.81466520
178primary alcohol metabolic process (GO:0034308)2.81229550
179gap junction assembly (GO:0016264)2.80333247
180regulation of keratinocyte proliferation (GO:0010837)2.78751763
181eyelid development in camera-type eye (GO:0061029)2.77224600
182positive regulation of chemokine secretion (GO:0090197)2.76773361
183diol metabolic process (GO:0034311)2.75783148
184bile acid and bile salt transport (GO:0015721)2.74279079
185head development (GO:0060322)2.72950638
186negative regulation of anoikis (GO:2000811)2.70447601
187regulation of glucose import in response to insulin stimulus (GO:2001273)2.68508797
188positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.67881630
189positive regulation of epidermal cell differentiation (GO:0045606)2.65286347
190regulation of glial cell proliferation (GO:0060251)2.60482761
191phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.59851438
192alditol phosphate metabolic process (GO:0052646)2.58327766
193positive regulation of growth hormone secretion (GO:0060124)2.57916703
194regulation of interleukin-8 secretion (GO:2000482)2.56797682
195positive regulation of Cdc42 GTPase activity (GO:0043089)2.55923189
196regulation of cellular extravasation (GO:0002691)12.2723149
197positive regulation of cAMP-mediated signaling (GO:0043950)10.4876221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.49962799
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.49466288
3E2F7_22180533_ChIP-Seq_HELA_Human5.42420983
4CDX2_20551321_ChIP-Seq_CACO-2_Human4.77188721
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.23703300
6VDR_21846776_ChIP-Seq_THP-1_Human3.73436895
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.27398089
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87906642
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81492493
10MYC_22102868_ChIP-Seq_BL_Human2.78636204
11VDR_24763502_ChIP-Seq_THP-1_Human2.75212346
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62693921
13ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.59585483
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56879288
15SCL_19346495_ChIP-Seq_HPC-7_Human2.53461193
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.43561479
17* GATA4_25053715_ChIP-Seq_YYC3_Human2.38387893
18SOX2_20726797_ChIP-Seq_SW620_Human2.35578812
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31173021
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30411854
21* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27301359
22* GATA6_25053715_ChIP-Seq_YYC3_Human2.25255642
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.24437467
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21590449
25SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21535677
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.19013946
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15006292
28UTX_26944678_Chip-Seq_JUKART_Human2.13042879
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09044002
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06892942
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.02506633
32KDM2B_26808549_Chip-Seq_DND41_Human2.00419383
33AR_21909140_ChIP-Seq_LNCAP_Human1.98243902
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94665191
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94459468
36* MAF_26560356_Chip-Seq_TH1_Human1.89282256
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86460603
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85874907
39RACK7_27058665_Chip-Seq_MCF-7_Human1.84234389
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84073269
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.79016072
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75009813
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74342151
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74264293
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.74015157
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72131316
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.71895057
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68827814
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68276970
50GATA1_22025678_ChIP-Seq_K562_Human1.67710205
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63752739
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63647420
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.63292929
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62059207
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61912308
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61419357
57GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.60998323
58* P68_20966046_ChIP-Seq_HELA_Human1.60228024
59OCT4_18692474_ChIP-Seq_MEFs_Mouse1.59260171
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57306367
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57262311
62TCF7_22412390_ChIP-Seq_EML_Mouse1.57044128
63MAF_26560356_Chip-Seq_TH2_Human1.56240334
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.55527687
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55122666
66LXR_22292898_ChIP-Seq_THP-1_Human1.54587839
67CIITA_25753668_ChIP-Seq_RAJI_Human1.52690433
68TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.50620100
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45019454
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.43241995
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.43239217
72SPI1_23127762_ChIP-Seq_K562_Human1.43082808
73CTCF_21964334_ChIP-Seq_BJAB-B_Human1.42913138
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42784195
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41847380
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40828641
77SPI1_20517297_ChIP-Seq_HL60_Human1.40583518
78* ATF3_27146783_Chip-Seq_COLON_Human1.40281098
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40140946
80* SA1_27219007_Chip-Seq_Bcells_Human1.39781530
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38806507
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38749572
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37515265
84STAT1_20625510_ChIP-Seq_HELA_Human1.36310097
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36199927
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.35316919
87ZNF263_19887448_ChIP-Seq_K562_Human1.32825758
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32253108
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31428292
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31343644
91PHF8_20622854_ChIP-Seq_HELA_Human1.30500538
92CLOCK_20551151_ChIP-Seq_293T_Human1.29762754
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28512677
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27670121
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.27637134
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27198267
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.26529527
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26127841
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26114901
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.25861816
101SPI1_23547873_ChIP-Seq_NB4_Human1.25388658
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.25027188
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25012497
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.22340627
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19171606
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18121187
107MYB_26560356_Chip-Seq_TH2_Human1.17117697
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.16297268
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.16297268
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16248349
111P300_27268052_Chip-Seq_Bcells_Human1.15952341
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15042325
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14229613
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14016385
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13641325
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13623099
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13256315
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13198489
119SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.13173587
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13021569
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12168463
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12089517
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11914456
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10777550
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10249586
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10172904
127CTCF_21964334_Chip-Seq_Bcells_Human1.09889669
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09655477
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07012402
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07012402
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06186280
132SMC4_20622854_ChIP-Seq_HELA_Human1.06036714
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05982850
134IRF8_22096565_ChIP-ChIP_GC-B_Human1.05353617
135* CTCF_27219007_Chip-Seq_Bcells_Human1.04963412
136SA1_27219007_Chip-Seq_ERYTHROID_Human1.04680039
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03405825
138YY1_22570637_ChIP-Seq_MALME-3M_Human1.03017511
139CTCF_20526341_ChIP-Seq_ESCs_Human1.03013926
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01614295
141DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00153638
142* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99516133
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98290801
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96812532
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96545310
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95658608
147NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95143553
148E2F1_20622854_ChIP-Seq_HELA_Human0.95121684
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94943451
150RUNX_20019798_ChIP-Seq_JUKART_Human0.94067598
151BCL6_27268052_Chip-Seq_Bcells_Human0.93602440
152OCT4_19829295_ChIP-Seq_ESCs_Human0.92991259
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92022200
154* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91541817
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91189654
156CREB1_26743006_Chip-Seq_LNCaP_Human0.90087973
157* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89993893
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89600928
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89510079
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89290153
161* NANOG_20526341_ChIP-Seq_ESCs_Human0.88250237
162SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87884701
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87774086
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.87610891
165XRN2_22483619_ChIP-Seq_HELA_Human0.87129496
166GATA3_24758297_ChIP-Seq_MCF-7_Human0.86536030
167TP63_22573176_ChIP-Seq_HFKS_Human0.85926580
168* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85584493
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85304673
170MYC_18555785_ChIP-Seq_MESCs_Mouse0.82535837
171BCOR_27268052_Chip-Seq_Bcells_Human0.82167829
172KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81786695
173HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81307094
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80754346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation7.54876193
2MP0003123_paternal_imprinting7.12391254
3MP0005451_abnormal_body_composition5.64347864
4MP0004264_abnormal_extraembryonic_tissu5.14442228
5MP0004145_abnormal_muscle_electrophysio5.10955311
6MP0000751_myopathy4.70102012
7MP0008004_abnormal_stomach_pH4.18923283
8MP0003646_muscle_fatigue4.10885429
9MP0000749_muscle_degeneration4.05561461
10MP0003787_abnormal_imprinting3.96804471
11MP0001663_abnormal_digestive_system3.34638214
12MP0004036_abnormal_muscle_relaxation3.14700873
13MP0000490_abnormal_crypts_of3.07027088
14MP0002106_abnormal_muscle_physiology3.02771506
15MP0001346_abnormal_lacrimal_gland2.96571812
16MP0003121_genomic_imprinting2.92188661
17MP0000537_abnormal_urethra_morphology2.89673657
18MP0000759_abnormal_skeletal_muscle2.88343201
19MP0004087_abnormal_muscle_fiber2.82084216
20MP0002163_abnormal_gland_morphology2.77768020
21MP0000747_muscle_weakness2.74895025
22MP0005381_digestive/alimentary_phenotyp2.66403305
23MP0000462_abnormal_digestive_system2.65520621
24MP0001835_abnormal_antigen_presentation2.62025699
25MP0005369_muscle_phenotype2.59088630
26MP0000013_abnormal_adipose_tissue2.56049773
27MP0010234_abnormal_vibrissa_follicle2.49574673
28MP0001666_abnormal_nutrient_absorption2.45768057
29MP0000750_abnormal_muscle_regeneration2.41157640
30MP0002269_muscular_atrophy2.35002946
31MP0006054_spinal_hemorrhage2.34616152
32MP0003866_abnormal_defecation2.30085818
33MP0003122_maternal_imprinting2.26438520
34MP0005360_urolithiasis2.24288837
35MP0010155_abnormal_intestine_physiology2.24154974
36MP0010352_gastrointestinal_tract_polyps2.13435602
37MP0004084_abnormal_cardiac_muscle2.11967623
38MP0005330_cardiomyopathy1.99711526
39MP0005620_abnormal_muscle_contractility1.97433244
40MP0003705_abnormal_hypodermis_morpholog1.94213852
41MP0006036_abnormal_mitochondrial_physio1.93839934
42MP0002332_abnormal_exercise_endurance1.89220703
43MP0002139_abnormal_hepatobiliary_system1.87253829
44MP0000477_abnormal_intestine_morphology1.83566528
45MP0001485_abnormal_pinna_reflex1.73297250
46MP0003806_abnormal_nucleotide_metabolis1.73140988
47MP0000733_abnormal_muscle_development1.64353513
48MP0001800_abnormal_humoral_immune1.63543026
49MP0005025_abnormal_response_to1.63157104
50MP0002108_abnormal_muscle_morphology1.58168094
51MP0002909_abnormal_adrenal_gland1.55914491
52MP0000685_abnormal_immune_system1.55675716
53MP0004272_abnormal_basement_membrane1.51769342
54MP0001664_abnormal_digestion1.50440637
55MP0000003_abnormal_adipose_tissue1.50224529
56MP0005187_abnormal_penis_morphology1.48717456
57MP0008438_abnormal_cutaneous_collagen1.46449720
58MP0003300_gastrointestinal_ulcer1.38704089
59MP0009278_abnormal_bone_marrow1.34954288
60MP0004130_abnormal_muscle_cell1.34609051
61MP0005000_abnormal_immune_tolerance1.33981645
62MP0003566_abnormal_cell_adhesion1.32626638
63MP0010630_abnormal_cardiac_muscle1.31884724
64MP0003763_abnormal_thymus_physiology1.30254231
65MP0002723_abnormal_immune_serum1.28452655
66MP0004019_abnormal_vitamin_homeostasis1.27115660
67MP0005266_abnormal_metabolism1.26044805
68MP0002148_abnormal_hypersensitivity_rea1.22786600
69MP0002796_impaired_skin_barrier1.22552730
70MP0005085_abnormal_gallbladder_physiolo1.21115772
71MP0002452_abnormal_antigen_presenting1.20511972
72MP0002972_abnormal_cardiac_muscle1.20480677
73MP0005464_abnormal_platelet_physiology1.18993923
74MP0002420_abnormal_adaptive_immunity1.18246658
75MP0002419_abnormal_innate_immunity1.18207942
76MP0003868_abnormal_feces_composition1.17244102
77MP0001348_abnormal_lacrimal_gland1.16727076
78MP0005379_endocrine/exocrine_gland_phen1.16387792
79MP0002086_abnormal_extraembryonic_tissu1.16227595
80MP0001819_abnormal_immune_cell1.15399793
81MP0009643_abnormal_urine_homeostasis1.14098804
82MP0003724_increased_susceptibility_to1.14085733
83MP0003693_abnormal_embryo_hatching1.13002776
84MP0004233_abnormal_muscle_weight1.12395158
85MP0002398_abnormal_bone_marrow1.12256896
86MP0002254_reproductive_system_inflammat1.09399982
87MP0003303_peritoneal_inflammation1.08862417
88MP0004957_abnormal_blastocyst_morpholog1.08481001
89MP0002837_dystrophic_cardiac_calcinosis1.03950462
90MP0000716_abnormal_immune_system1.02500056
91MP0009785_altered_susceptibility_to1.01826874
92MP0008872_abnormal_physiological_respon1.01306773
93MP0006138_congestive_heart_failure1.00597079
94MP0005076_abnormal_cell_differentiation0.99617107
95MP0003879_abnormal_hair_cell0.97773505
96MP0005332_abnormal_amino_acid0.96773698
97MP0003436_decreased_susceptibility_to0.95079543
98MP0001756_abnormal_urination0.94726586
99MP0005375_adipose_tissue_phenotype0.94583867
100MP0008469_abnormal_protein_level0.94327532
101MP0006082_CNS_inflammation0.93900357
102MP0000689_abnormal_spleen_morphology0.93529674
103MP0000372_irregular_coat_pigmentation0.92719226
104MP0003252_abnormal_bile_duct0.90813372
105MP0005164_abnormal_response_to0.90725793
106MP0008961_abnormal_basal_metabolism0.90689230
107MP0003567_abnormal_fetal_cardiomyocyte0.90166724
108MP0002429_abnormal_blood_cell0.88263838
109MP0004883_abnormal_blood_vessel0.87985323
110MP0002722_abnormal_immune_system0.87207774
111MP0005365_abnormal_bile_salt0.86352213
112MP0004215_abnormal_myocardial_fiber0.86329455
113MP0002166_altered_tumor_susceptibility0.85603413
114MP0005319_abnormal_enzyme/_coenzyme0.85488337
115MP0003453_abnormal_keratinocyte_physiol0.85136279
116MP0001944_abnormal_pancreas_morphology0.84754177
117MP0002693_abnormal_pancreas_physiology0.84021971
118MP0004185_abnormal_adipocyte_glucose0.83676913
119MP0001849_ear_inflammation0.83376519
120MP0002138_abnormal_hepatobiliary_system0.82698214
121MP0003315_abnormal_perineum_morphology0.81375161
122MP0002127_abnormal_cardiovascular_syste0.79690719
123MP0005666_abnormal_adipose_tissue0.78539902
124MP0001790_abnormal_immune_system0.78152340
125MP0005387_immune_system_phenotype0.78152340
126MP0005671_abnormal_response_to0.77934720
127MP0002877_abnormal_melanocyte_morpholog0.77904851
128MP0005058_abnormal_lysosome_morphology0.76769700
129MP0009840_abnormal_foam_cell0.75818183
130MP0000470_abnormal_stomach_morphology0.75641508
131MP0003828_pulmonary_edema0.74703168
132MP0002971_abnormal_brown_adipose0.73604606
133MP0000703_abnormal_thymus_morphology0.73255796
134MP0001661_extended_life_span0.72898800
135MP0010329_abnormal_lipoprotein_level0.72158194
136MP0005166_decreased_susceptibility_to0.69556083
137MP0002098_abnormal_vibrissa_morphology0.69295185
138MP0005385_cardiovascular_system_phenoty0.67775085
139MP0001544_abnormal_cardiovascular_syste0.67775085
140MP0002998_abnormal_bone_remodeling0.67676641
141MP0004043_abnormal_pH_regulation0.66248494
142MP0005310_abnormal_salivary_gland0.65645816
143MP0009764_decreased_sensitivity_to0.65224138
144MP0000465_gastrointestinal_hemorrhage0.65121363
145MP0003191_abnormal_cellular_cholesterol0.64732109
146MP0001730_embryonic_growth_arrest0.64395449
147MP0008875_abnormal_xenobiotic_pharmacok0.63812267
148MP0005165_increased_susceptibility_to0.63350507
149MP0006035_abnormal_mitochondrial_morpho0.63307124
150MP0008260_abnormal_autophagy0.63197928
151MP0004484_altered_response_of0.62775548
152MP0003119_abnormal_digestive_system0.62211914
153MP0002396_abnormal_hematopoietic_system0.62030137
154MP0004197_abnormal_fetal_growth/weight/0.61495706
155MP0003959_abnormal_lean_body0.60273200
156MP0002735_abnormal_chemical_nociception0.58258437
157MP0005501_abnormal_skin_physiology0.58052599
158MP0004142_abnormal_muscle_tone0.57999786
159MP0003183_abnormal_peptide_metabolism0.57664703
160MP0003795_abnormal_bone_structure0.56799581
161MP0010386_abnormal_urinary_bladder0.56716535
162MP0010030_abnormal_orbit_morphology0.56412411
163MP0002653_abnormal_ependyma_morphology0.54929379
164MP0005023_abnormal_wound_healing0.54025636
165MP0004782_abnormal_surfactant_physiolog0.51902129
166MP0004510_myositis0.51868891
167MP0009333_abnormal_splenocyte_physiolog0.51388608
168MP0004947_skin_inflammation0.51065741
169MP0004858_abnormal_nervous_system0.48976621
170MP0003984_embryonic_growth_retardation0.47642929
171MP0005376_homeostasis/metabolism_phenot0.47528926
172MP0010678_abnormal_skin_adnexa0.46653138
173MP0009697_abnormal_copulation0.46617930
174MP0001845_abnormal_inflammatory_respons0.46536337
175MP0000639_abnormal_adrenal_gland0.46252606
176MP0002088_abnormal_embryonic_growth/wei0.46183217
177MP0003638_abnormal_response/metabolism_0.45574638
178MP0005448_abnormal_energy_balance0.44119141
179MP0001216_abnormal_epidermal_layer0.43411344
180MP0005220_abnormal_exocrine_pancreas0.42582824
181MP0000609_abnormal_liver_physiology0.41632503

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.32064736
2Muscle fiber inclusion bodies (HP:0100299)9.04529872
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.70522127
4Distal arthrogryposis (HP:0005684)7.71551994
5Posterior subcapsular cataract (HP:0007787)7.34958098
6Ventricular fibrillation (HP:0001663)7.16335386
7Congenital sensorineural hearing impairment (HP:0008527)6.63625153
8Type 1 muscle fiber predominance (HP:0003803)6.62509479
9Exercise-induced myalgia (HP:0003738)6.62194547
10Round ear (HP:0100830)5.98585578
11Myopathic facies (HP:0002058)5.90651644
12Right ventricular cardiomyopathy (HP:0011663)5.74572401
13Micronodular cirrhosis (HP:0001413)5.43358754
14Ulnar deviation of the wrist (HP:0003049)5.43191288
15Adrenal overactivity (HP:0002717)5.37738059
16Calcaneovalgus deformity (HP:0001848)5.33592277
17Late onset (HP:0003584)5.19450101
18Chorioretinal atrophy (HP:0000533)5.05833484
19Agammaglobulinemia (HP:0004432)5.02428371
20Exercise-induced muscle cramps (HP:0003710)5.01810334
21Deformed tarsal bones (HP:0008119)4.66388682
22Ketoacidosis (HP:0001993)4.65406254
23Muscle hypertrophy of the lower extremities (HP:0008968)4.40194845
24Abnormality of the pancreatic islet cells (HP:0006476)4.31817929
25Abnormality of endocrine pancreas physiology (HP:0012093)4.31817929
26Centrally nucleated skeletal muscle fibers (HP:0003687)4.24849400
27Abdominal distention (HP:0003270)4.16664235
28Abnormality of skeletal muscle fiber size (HP:0012084)4.08005787
29Syncope (HP:0001279)4.04846408
30Esophageal varix (HP:0002040)4.04514495
31Calf muscle hypertrophy (HP:0008981)4.00727160
32EMG: myopathic abnormalities (HP:0003458)3.97458399
33Absent phalangeal crease (HP:0006109)3.88650678
34Malignant hyperthermia (HP:0002047)3.88471312
35Subcapsular cataract (HP:0000523)3.85068359
36Pili torti (HP:0003777)3.81436922
37Fetal akinesia sequence (HP:0001989)3.76999396
38Ileus (HP:0002595)3.73310933
39Neck muscle weakness (HP:0000467)3.71247757
40Muscle fiber splitting (HP:0003555)3.65150649
41Hyporeflexia of lower limbs (HP:0002600)3.44347286
42Popliteal pterygium (HP:0009756)3.41151187
43Multifactorial inheritance (HP:0001426)3.22864977
44Woolly hair (HP:0002224)3.17235756
45Increased variability in muscle fiber diameter (HP:0003557)3.13678404
46Abnormality of the calcaneus (HP:0008364)3.13286637
47Thin bony cortex (HP:0002753)3.11206718
48Rhabdomyolysis (HP:0003201)3.09093093
49Abnormal finger flexion creases (HP:0006143)3.08731650
50Insulin resistance (HP:0000855)3.08224571
51Myoglobinuria (HP:0002913)3.07202892
52Bulbar palsy (HP:0001283)3.06162089
53Abnormality of the calf musculature (HP:0001430)2.97012526
54Confusion (HP:0001289)2.96863524
55Type 2 muscle fiber atrophy (HP:0003554)2.94727989
56Difficulty running (HP:0009046)2.92866421
57Abnormal pancreas size (HP:0012094)2.92487980
58Rimmed vacuoles (HP:0003805)2.90105382
59Subaortic stenosis (HP:0001682)2.86739025
60Abnormality of the left ventricular outflow tract (HP:0011103)2.86739025
61Increased connective tissue (HP:0009025)2.86685319
62Ventricular arrhythmia (HP:0004308)2.86243194
63Muscle fiber atrophy (HP:0100295)2.84398194
64Weak cry (HP:0001612)2.82070356
65Autoimmune hemolytic anemia (HP:0001890)2.82047241
66Abnormality of vitamin B metabolism (HP:0004340)2.81386798
67Cellulitis (HP:0100658)2.76307624
68Prolonged QT interval (HP:0001657)2.72875452
69Palpitations (HP:0001962)2.71747706
70Muscle stiffness (HP:0003552)2.69791832
71Distal lower limb muscle weakness (HP:0009053)2.68824389
72Ketosis (HP:0001946)2.68535239
73Increased IgE level (HP:0003212)2.68087269
74Abnormality of B cell number (HP:0010975)2.62865237
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60051423
76Abnormality of the vitamin B12 metabolism (HP:0004341)2.59555445
77Frequent falls (HP:0002359)2.56797787
78Hypoglycemic coma (HP:0001325)2.55426864
79Growth hormone excess (HP:0000845)2.51303553
80Generalized muscle weakness (HP:0003324)2.49939812
81Hyperglycemia (HP:0003074)2.48187591
82Asymmetric septal hypertrophy (HP:0001670)2.46402751
83Abnormality of the neuromuscular junction (HP:0003398)2.45718755
84Fatigable weakness (HP:0003473)2.45718755
85Metatarsus adductus (HP:0001840)2.43802128
86EMG: neuropathic changes (HP:0003445)2.42090584
87Hip contracture (HP:0003273)2.39145449
88Hyperparathyroidism (HP:0000843)2.38670182
89B lymphocytopenia (HP:0010976)2.38342842
90Abnormality of vitamin metabolism (HP:0100508)2.37766571
91Mesangial abnormality (HP:0001966)2.33249415
92Abnormal hair laboratory examination (HP:0003328)2.27651917
93Trismus (HP:0000211)2.27106216
94Symptomatic seizures (HP:0011145)2.24754824
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22729783
96Gowers sign (HP:0003391)2.22005512
97Conjunctival hamartoma (HP:0100780)2.21111413
98Hepatic necrosis (HP:0002605)2.21099029
99Mildly elevated creatine phosphokinase (HP:0008180)2.20829642
100Areflexia of lower limbs (HP:0002522)2.20728077
101Myotonia (HP:0002486)2.19527881
102Biliary tract neoplasm (HP:0100574)2.18259563
103Abnormality of placental membranes (HP:0011409)2.18213258
104Amniotic constriction ring (HP:0009775)2.18213258
105Long clavicles (HP:0000890)2.17886856
106Abnormal EKG (HP:0003115)2.17561411
107Hyperammonemia (HP:0001987)2.16784075
108Recurrent pneumonia (HP:0006532)2.16654904
109Neoplasm of the rectum (HP:0100743)2.13972177
110Sudden death (HP:0001699)2.13735747
111Recurrent viral infections (HP:0004429)2.09694580
112Increased muscle lipid content (HP:0009058)2.09005610
113Easy fatigability (HP:0003388)2.08775808
114Selective tooth agenesis (HP:0001592)2.06696764
115Polar cataract (HP:0010696)2.04217535
116Meningitis (HP:0001287)2.02110318
117Limb-girdle muscle atrophy (HP:0003797)2.01065066
118Ankyloglossia (HP:0010296)2.00424132
119Hypercortisolism (HP:0001578)11.2886443
120Hepatocellular necrosis (HP:0001404)1.99845923
121Abnormality of the gastric mucosa (HP:0004295)1.99572069
122Alopecia of scalp (HP:0002293)1.99562735
123Bone cyst (HP:0012062)1.97520456
124Villous atrophy (HP:0011473)1.95203979
125Abnormality of small intestinal villus morphology (HP:0011472)1.95203979
126Distal lower limb amyotrophy (HP:0008944)1.95200010
127Recurrent fungal infections (HP:0002841)1.94862984
128Neoplasm of the small intestine (HP:0100833)1.94791967
129Adducted thumb (HP:0001181)1.94419787
130Recurrent lower respiratory tract infections (HP:0002783)1.93821652
131Colitis (HP:0002583)1.93766135
132Lethargy (HP:0001254)1.93235043
133Recurrent cutaneous fungal infections (HP:0011370)1.93187820
134Chronic mucocutaneous candidiasis (HP:0002728)1.93187820
135Aplasia of the musculature (HP:0100854)1.89721920
136Slender build (HP:0001533)1.89217022
137Sepsis (HP:0100806)1.88858241
138Polygenic inheritance (HP:0010982)1.86655010
139Abnormal biliary tract morphology (HP:0012440)1.85471249
140Dilated cardiomyopathy (HP:0001644)1.85277219
141Back pain (HP:0003418)1.83430876
142Thin ribs (HP:0000883)1.83046607
143Metaphyseal dysplasia (HP:0100255)1.82877102
144Lipid accumulation in hepatocytes (HP:0006561)1.82194891
145Pheochromocytoma (HP:0002666)1.81790673
14611 pairs of ribs (HP:0000878)1.81616608
147Gastrointestinal inflammation (HP:0004386)1.80874972
148Inflammation of the large intestine (HP:0002037)1.79879672
149Eczematoid dermatitis (HP:0000976)1.78882104
150Cupped ribs (HP:0000887)1.77886585
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77583503
152Waddling gait (HP:0002515)1.77274738
153Wide cranial sutures (HP:0010537)1.76944109
154Severe combined immunodeficiency (HP:0004430)1.75800195
155Pustule (HP:0200039)1.75274242
156Breech presentation (HP:0001623)1.75156559
157Mitochondrial inheritance (HP:0001427)1.74707025
158Sparse eyelashes (HP:0000653)1.74665162
159Increased intramyocellular lipid droplets (HP:0012240)1.74464814
160Autoimmune thrombocytopenia (HP:0001973)1.73592166
161Panhypogammaglobulinemia (HP:0003139)1.73229766
162Curly hair (HP:0002212)1.72995730
163Chronic sinusitis (HP:0011109)1.72044764
164Scapular winging (HP:0003691)1.71993340
165Abnormality of proline metabolism (HP:0010907)1.71474909
166Hydroxyprolinuria (HP:0003080)1.71474909
167Abnormality of urine glucose concentration (HP:0011016)1.70706318
168Glycosuria (HP:0003076)1.70706318
169Multiple enchondromatosis (HP:0005701)1.70681167
170Neuroendocrine neoplasm (HP:0100634)1.69301971
171Menstrual irregularities (HP:0000858)1.68799216
172Abnormal mitochondria in muscle tissue (HP:0008316)1.68142785
173Increased purine levels (HP:0004368)1.67469908
174Hyperuricemia (HP:0002149)1.67469908
175Ragged-red muscle fibers (HP:0003200)1.67408511
176Cerebral palsy (HP:0100021)1.67005433
177Osteomyelitis (HP:0002754)1.66984242
178Cardiomegaly (HP:0001640)1.66537019
179Delayed epiphyseal ossification (HP:0002663)1.64336857
180Protuberant abdomen (HP:0001538)1.63347669
181Hypercalcemia (HP:0003072)1.63122928
182Acute encephalopathy (HP:0006846)1.62883698
183Intestinal polyposis (HP:0200008)1.62233050
184Adenoma sebaceum (HP:0009720)1.61858065
185Angiofibromas (HP:0010615)1.61858065
186Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61316521
187Dicarboxylic aciduria (HP:0003215)1.61316521
188Oral leukoplakia (HP:0002745)1.60959710
189Muscle fibrillation (HP:0010546)1.59505470
190Stenosis of the external auditory canal (HP:0000402)1.58845496
191Deep venous thrombosis (HP:0002625)1.53037139
192Progressive muscle weakness (HP:0003323)1.52802668
193Increased CSF lactate (HP:0002490)1.52542517
194Abnormality of purine metabolism (HP:0004352)1.49867816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.17023279
2MAP2K24.53837409
3RPS6KB24.53289297
4NME14.45460496
5PIK3CG4.25713854
6TRIB33.73161821
7TTN3.56783693
8MAP2K63.35802535
9PKN23.17175515
10MAP4K13.01045673
11TESK22.96728921
12TYK22.84812880
13PHKG12.81871605
14PHKG22.81871605
15PTK62.58721065
16SCYL22.32710412
17NME22.25880500
18MAPK122.25336620
19MAP2K12.17067228
20IKBKE2.13704990
21PTK21.93934281
22MAP3K21.88646069
23PAK41.86084162
24MOS1.78219397
25MAPK151.75865692
26MAP3K31.74345610
27CDK81.74330411
28BUB11.72702618
29CAMK2B1.72500535
30KIT1.71604032
31MAP3K131.71311327
32ERN11.70591672
33PIM21.65690109
34PRKG21.63314053
35VRK21.61574828
36MAP3K101.61078812
37BLK1.60776156
38PLK41.58156921
39MAP3K111.57024476
40FRK1.55436868
41MUSK1.55435292
42MST41.54372873
43CAMK2D1.52426363
44TESK11.51649533
45LRRK21.43477293
46LMTK21.43001387
47CAMK2G1.38425164
48WNK31.38138372
49CSF1R1.33558653
50FER1.28364485
51KSR21.22253223
52RIPK41.16323885
53MAP3K71.15514756
54EPHA21.14255669
55FLT31.12118412
56TNK21.11245274
57MAP3K81.10323922
58MAP3K121.09474729
59DAPK21.08790673
60TBK11.07708701
61ILK1.07548208
62MAPKAPK31.05464949
63PRKCI1.05212366
64WNK41.03739126
65MST1R1.01679547
66SYK0.98494768
67LIMK10.94949653
68MAP2K30.94893568
69BCKDK0.92792925
70SIK10.90373599
71SIK30.88492554
72CDK190.87618999
73EPHB20.85922843
74MAP3K10.83857910
75PAK10.82543492
76TRPM70.78466135
77PRPF4B0.78266346
78MAPK70.78082958
79MET0.77794872
80ARAF0.77787885
81GRK60.74634125
82AKT20.72700357
83PDPK10.72032672
84STK100.71772527
85ERBB20.69245911
86KDR0.68959088
87BRAF0.68750591
88DYRK1B0.68100722
89NEK10.67810768
90HIPK20.67331984
91MAPKAPK50.65849067
92ZAP700.65792302
93DAPK10.64334383
94RAF10.64214277
95NEK90.62965335
96PINK10.62739153
97MATK0.61998348
98MARK20.61736272
99CLK10.61620256
100EEF2K0.61201891
101WEE10.60194788
102HCK0.58926962
103JAK30.57977009
104TAOK10.57923416
105EPHB10.57603646
106CDC42BPA0.57457019
107KSR10.56738621
108NEK20.53636674
109SIK20.53470750
110PAK30.53085926
111MAPK110.52794412
112RPS6KA40.51760787
113GRK70.51097847
114MAPKAPK20.50426266
115CCNB10.47307313
116MAPK40.46538993
117MAPK130.46130329
118RET0.45497715
119DMPK0.44264715
120TTK0.40915784
121PKN10.38507537
122CDK40.38325268
123TGFBR20.38282633
124LATS20.38235986
125PRKCQ0.38150562
126AURKB0.36933709
127SRC0.36385583
128IKBKB0.36267365
129CAMKK10.35667152
130FGFR40.35649827
131VRK10.35647470
132ROCK10.35169989
133ABL20.35121151
134BMPR20.34219820
135DAPK30.34180009
136PASK0.33366610
137CDK70.33352927
138RPS6KA10.33089597
139MYLK0.32494017
140CSNK1A10.32176764
141TEC0.32003010
142BMX0.31803972
143SMG10.31799934
144MARK30.31573050
145RIPK10.31158136
146LCK0.30878173
147PRKCA0.30629268
148LYN0.30582981
149AKT30.29788111
150BTK0.29688517
151ROCK20.29608791
152PDK10.28873373
153CSNK1E0.27996765
154IRAK40.27904648
155JAK20.27415113
156CSNK1D0.26960035
157JAK10.26713413
158CDK90.25925344
159PRKAA20.25545495
160PBK0.25180296
161EGFR0.24458850
162CDK150.24254628
163CAMK40.23801360
164CAMK2A0.23122352
165GSK3A0.22557188
166CSK0.22420470
167PRKCD0.21149288

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.22200145
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.12034375
3Primary immunodeficiency_Homo sapiens_hsa053404.03331694
4Histidine metabolism_Homo sapiens_hsa003403.84897613
5Autoimmune thyroid disease_Homo sapiens_hsa053203.60979557
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.57133696
7Viral myocarditis_Homo sapiens_hsa054163.17682854
8Asthma_Homo sapiens_hsa053103.09042288
9Arginine and proline metabolism_Homo sapiens_hsa003303.04636904
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82944032
11Allograft rejection_Homo sapiens_hsa053302.73391420
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67751277
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.65354380
14Graft-versus-host disease_Homo sapiens_hsa053322.54536737
15Linoleic acid metabolism_Homo sapiens_hsa005912.52445729
16Tryptophan metabolism_Homo sapiens_hsa003802.52419445
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.51339663
18Pyruvate metabolism_Homo sapiens_hsa006202.48283159
19Fatty acid degradation_Homo sapiens_hsa000712.44459304
20Fat digestion and absorption_Homo sapiens_hsa049752.34711334
21DNA replication_Homo sapiens_hsa030302.24229167
22beta-Alanine metabolism_Homo sapiens_hsa004102.10395509
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09122394
24Nitrogen metabolism_Homo sapiens_hsa009102.01464084
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92850740
26B cell receptor signaling pathway_Homo sapiens_hsa046621.91925059
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.91045891
28Dilated cardiomyopathy_Homo sapiens_hsa054141.90600312
29Parkinsons disease_Homo sapiens_hsa050121.90437597
30Type I diabetes mellitus_Homo sapiens_hsa049401.89949732
31Oxidative phosphorylation_Homo sapiens_hsa001901.88976939
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88370323
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85113255
34Arachidonic acid metabolism_Homo sapiens_hsa005901.81539342
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80548810
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.75846267
37Insulin secretion_Homo sapiens_hsa049111.75016304
38Leishmaniasis_Homo sapiens_hsa051401.64051940
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62481657
40Base excision repair_Homo sapiens_hsa034101.61257509
41Tight junction_Homo sapiens_hsa045301.54430722
42Glycerolipid metabolism_Homo sapiens_hsa005611.49650263
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.48083837
44Herpes simplex infection_Homo sapiens_hsa051681.45662333
45Galactose metabolism_Homo sapiens_hsa000521.44801130
46Vibrio cholerae infection_Homo sapiens_hsa051101.44372458
47Glutathione metabolism_Homo sapiens_hsa004801.43733548
48Tuberculosis_Homo sapiens_hsa051521.43523697
49Fructose and mannose metabolism_Homo sapiens_hsa000511.41132183
50Regulation of autophagy_Homo sapiens_hsa041401.40957768
51Staphylococcus aureus infection_Homo sapiens_hsa051501.37571183
52Measles_Homo sapiens_hsa051621.33590142
53Osteoclast differentiation_Homo sapiens_hsa043801.29989718
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23564695
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23473730
56Proteasome_Homo sapiens_hsa030501.22909384
57Alzheimers disease_Homo sapiens_hsa050101.17824839
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17712333
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16568707
60Ether lipid metabolism_Homo sapiens_hsa005651.14591150
61Huntingtons disease_Homo sapiens_hsa050161.13564207
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12765758
63Non-small cell lung cancer_Homo sapiens_hsa052231.11851904
64Pentose phosphate pathway_Homo sapiens_hsa000301.10123851
65Sulfur metabolism_Homo sapiens_hsa009201.09922926
66Platelet activation_Homo sapiens_hsa046111.07480569
67Hepatitis C_Homo sapiens_hsa051601.05714420
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00385025
69Bladder cancer_Homo sapiens_hsa052190.98205185
70Insulin resistance_Homo sapiens_hsa049310.97617058
71Sulfur relay system_Homo sapiens_hsa041220.94466584
72N-Glycan biosynthesis_Homo sapiens_hsa005100.93643169
73Toxoplasmosis_Homo sapiens_hsa051450.92252351
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90909167
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89831334
76Arginine biosynthesis_Homo sapiens_hsa002200.88357685
77Pyrimidine metabolism_Homo sapiens_hsa002400.88199960
78VEGF signaling pathway_Homo sapiens_hsa043700.87549234
79Glucagon signaling pathway_Homo sapiens_hsa049220.86781399
80Carbon metabolism_Homo sapiens_hsa012000.86670136
81PPAR signaling pathway_Homo sapiens_hsa033200.85579901
82Thyroid cancer_Homo sapiens_hsa052160.85373599
83Pancreatic cancer_Homo sapiens_hsa052120.85018304
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84899164
85Hepatitis B_Homo sapiens_hsa051610.82670317
86Oxytocin signaling pathway_Homo sapiens_hsa049210.80108198
87Lysine degradation_Homo sapiens_hsa003100.79080359
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78837503
89Calcium signaling pathway_Homo sapiens_hsa040200.78726069
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.75054718
91Insulin signaling pathway_Homo sapiens_hsa049100.73598929
92Circadian rhythm_Homo sapiens_hsa047100.71261105
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.67890766
94Nucleotide excision repair_Homo sapiens_hsa034200.66055704
95Folate biosynthesis_Homo sapiens_hsa007900.65729137
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64054344
97Biosynthesis of amino acids_Homo sapiens_hsa012300.61744261
98Pancreatic secretion_Homo sapiens_hsa049720.60535379
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60383565
100Systemic lupus erythematosus_Homo sapiens_hsa053220.59970987
101Cardiac muscle contraction_Homo sapiens_hsa042600.59054909
102Bile secretion_Homo sapiens_hsa049760.58902754
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56800768
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54991459
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54696625
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54169545
107Mineral absorption_Homo sapiens_hsa049780.54113937
108Salmonella infection_Homo sapiens_hsa051320.51379823
109Acute myeloid leukemia_Homo sapiens_hsa052210.50616435
110Hematopoietic cell lineage_Homo sapiens_hsa046400.48486941
111Mismatch repair_Homo sapiens_hsa034300.46379288
112Viral carcinogenesis_Homo sapiens_hsa052030.46234929
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46190235
114Protein digestion and absorption_Homo sapiens_hsa049740.46149104
115Purine metabolism_Homo sapiens_hsa002300.45619059
116Epstein-Barr virus infection_Homo sapiens_hsa051690.44570688
117Thyroid hormone synthesis_Homo sapiens_hsa049180.44025005
118HTLV-I infection_Homo sapiens_hsa051660.43408297
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40691083
120Protein export_Homo sapiens_hsa030600.39935556
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39474807
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.39172105
123Metabolic pathways_Homo sapiens_hsa011000.38532434
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.37582952
125Amoebiasis_Homo sapiens_hsa051460.36390155
126Shigellosis_Homo sapiens_hsa051310.36161515
127T cell receptor signaling pathway_Homo sapiens_hsa046600.35005645
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34276444
129Selenocompound metabolism_Homo sapiens_hsa004500.34106104
130Chronic myeloid leukemia_Homo sapiens_hsa052200.33558707
131Apoptosis_Homo sapiens_hsa042100.33076416
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.32641657
133Vitamin digestion and absorption_Homo sapiens_hsa049770.30979707
134GnRH signaling pathway_Homo sapiens_hsa049120.29869139
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.29366111
136Pertussis_Homo sapiens_hsa051330.27836336
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26930217
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25900209
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.25807097
140Gastric acid secretion_Homo sapiens_hsa049710.25639657
141Phagosome_Homo sapiens_hsa041450.25343748
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24589809
143Starch and sucrose metabolism_Homo sapiens_hsa005000.24420173
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24267338
145Other glycan degradation_Homo sapiens_hsa005110.23125756
146Chemokine signaling pathway_Homo sapiens_hsa040620.22518228
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.22087185
148Cocaine addiction_Homo sapiens_hsa050300.22069646
149AMPK signaling pathway_Homo sapiens_hsa041520.21891425
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.21620417
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21266164
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20699981
153Primary bile acid biosynthesis_Homo sapiens_hsa001200.20400504
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19979327
155Ribosome_Homo sapiens_hsa030100.19568772
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18416352
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16655447
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15532397
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13289219
160Estrogen signaling pathway_Homo sapiens_hsa049150.13269900
161Renal cell carcinoma_Homo sapiens_hsa052110.12816040
162Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12474222
163Influenza A_Homo sapiens_hsa051640.12358919
164Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12171637
165Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11422845
166Propanoate metabolism_Homo sapiens_hsa006400.11379869
167Peroxisome_Homo sapiens_hsa041460.10976557
168Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09181161
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08154143
170Antigen processing and presentation_Homo sapiens_hsa046120.06309713

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