SCPEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.82534662
2COPI coating of Golgi vesicle (GO:0048205)4.13319407
3Golgi transport vesicle coating (GO:0048200)4.13319407
4detection of other organism (GO:0098543)4.06806826
5glycosphingolipid catabolic process (GO:0046479)4.05722481
6axonemal dynein complex assembly (GO:0070286)3.83876573
7detection of bacterium (GO:0016045)3.78313887
8cellular response to thyroid hormone stimulus (GO:0097067)3.68882080
9detection of external biotic stimulus (GO:0098581)3.68809245
10cellular extravasation (GO:0045123)3.63587345
11glycolipid catabolic process (GO:0019377)3.63058215
12positive regulation of gamma-delta T cell activation (GO:0046645)3.59581496
13negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.54178525
14apoptotic cell clearance (GO:0043277)3.49364575
15antigen processing and presentation of endogenous antigen (GO:0019883)3.49259908
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.47325484
17negative regulation of cell killing (GO:0031342)3.47325484
18keratan sulfate catabolic process (GO:0042340)3.47183329
19oligosaccharide catabolic process (GO:0009313)3.43767839
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.43345929
21regulation of tolerance induction (GO:0002643)3.41571123
22amino sugar catabolic process (GO:0046348)3.40139320
23collagen fibril organization (GO:0030199)3.36047550
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32073459
25interferon-gamma-mediated signaling pathway (GO:0060333)3.28805779
26detection of biotic stimulus (GO:0009595)3.27772429
27protein heterotrimerization (GO:0070208)3.24210540
28ceramide catabolic process (GO:0046514)3.22618965
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22209285
30granulocyte activation (GO:0036230)3.22050332
31cell adhesion mediated by integrin (GO:0033627)3.21536721
32positive regulation of cellular amide metabolic process (GO:0034250)3.21215561
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.17603484
34chondrocyte proliferation (GO:0035988)3.15771416
35regulation of mast cell degranulation (GO:0043304)3.11985734
36hydrogen peroxide biosynthetic process (GO:0050665)3.11225401
37endodermal cell differentiation (GO:0035987)3.09844792
38cilium or flagellum-dependent cell motility (GO:0001539)3.09146637
39macrophage activation (GO:0042116)3.08627085
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07788409
41type I interferon signaling pathway (GO:0060337)3.07051671
42cellular response to type I interferon (GO:0071357)3.07051671
43wound healing, spreading of epidermal cells (GO:0035313)3.05132714
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04530358
45regulation of integrin activation (GO:0033623)3.04348907
46response to type I interferon (GO:0034340)3.03758248
47response to thyroid hormone (GO:0097066)3.03270375
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.01731322
49modulation by symbiont of host immune response (GO:0052553)3.01731322
50positive regulation by symbiont of host defense response (GO:0052509)3.01731322
51modulation by symbiont of host defense response (GO:0052031)3.01731322
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01731322
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01731322
54neutrophil activation (GO:0042119)3.00468894
55T-helper 1 type immune response (GO:0042088)2.98786056
56protein retention in ER lumen (GO:0006621)2.98343201
57folic acid-containing compound biosynthetic process (GO:0009396)2.97398731
58basement membrane organization (GO:0071711)2.97044782
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.96114552
60skin morphogenesis (GO:0043589)2.95517674
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.95450259
62myeloid cell activation involved in immune response (GO:0002275)2.95327642
63regulation of leukocyte degranulation (GO:0043300)2.95212734
64positive regulation of mast cell activation (GO:0033005)2.92889581
65regulation of SMAD protein import into nucleus (GO:0060390)2.92736141
66peptide catabolic process (GO:0043171)2.92573659
67response to muramyl dipeptide (GO:0032495)2.92452668
68positive regulation of tolerance induction (GO:0002645)2.92052606
69positive regulation of leukocyte degranulation (GO:0043302)2.91658414
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91144064
71regulation of mitotic spindle organization (GO:0060236)2.89140606
72positive regulation of type 2 immune response (GO:0002830)2.85268693
73positive regulation of antigen processing and presentation (GO:0002579)2.84634656
74regulation of mast cell activation involved in immune response (GO:0033006)2.84047238
75reactive oxygen species biosynthetic process (GO:1903409)2.83711600
76germinal center formation (GO:0002467)2.83193102
77regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83081185
78regulation of antigen processing and presentation (GO:0002577)2.81544333
79respiratory burst (GO:0045730)2.80780667
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.80632034
81positive regulation of mast cell degranulation (GO:0043306)2.80632034
82regulation of macrophage chemotaxis (GO:0010758)2.80530941
83microglial cell activation (GO:0001774)2.79738143
84response to xenobiotic stimulus (GO:0009410)2.79315705
85cellular response to interferon-alpha (GO:0035457)2.79182070
86regulation of T-helper 2 cell differentiation (GO:0045628)2.78967490
87low-density lipoprotein particle clearance (GO:0034383)2.78949404
88paraxial mesoderm development (GO:0048339)2.78881704
89regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.78290690
90positive regulation of monocyte chemotaxis (GO:0090026)2.78205774
91N-acetylneuraminate metabolic process (GO:0006054)2.77777221
92regulation of interferon-beta biosynthetic process (GO:0045357)2.77010735
93response to host immune response (GO:0052572)2.76657503
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76657503
95eosinophil chemotaxis (GO:0048245)2.75617467
96regulation of podosome assembly (GO:0071801)2.75360020
97regulation of superoxide anion generation (GO:0032928)2.74271595
98negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71441729
99cellular response to vitamin (GO:0071295)2.71166198
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70896594
101regulation of mononuclear cell migration (GO:0071675)2.69588462
102regulation of T cell tolerance induction (GO:0002664)2.69527262
103activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.69340399
104regulation of integrin-mediated signaling pathway (GO:2001044)2.69260877
105barbed-end actin filament capping (GO:0051016)2.67589272
106membrane lipid catabolic process (GO:0046466)2.67528792
107positive regulation of interferon-alpha production (GO:0032727)2.67216877
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.66384353
109negative regulation of erythrocyte differentiation (GO:0045647)2.66129345
110sphingolipid catabolic process (GO:0030149)2.65243113
111wound healing, spreading of cells (GO:0044319)2.63918969
112regulation of mast cell activation (GO:0033003)2.63775505
113positive regulation of endothelial cell apoptotic process (GO:2000353)2.62915086
114cellular response to interferon-gamma (GO:0071346)2.62460516
115positive regulation of nuclease activity (GO:0032075)2.62411481
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61819510
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.60822077
118production of molecular mediator involved in inflammatory response (GO:0002532)2.59801858
119negative regulation of cytokine production involved in immune response (GO:0002719)2.59783137
120myeloid dendritic cell differentiation (GO:0043011)2.59348922
121regulation of gamma-delta T cell activation (GO:0046643)2.57339828
122negative regulation of fatty acid transport (GO:2000192)2.55437796
123regulation of spindle organization (GO:0090224)2.55067275
124protein localization to kinetochore (GO:0034501)2.53411857
125immunoglobulin mediated immune response (GO:0016064)2.52943329
126endoplasmic reticulum unfolded protein response (GO:0030968)2.52198573
127regulation of interferon-alpha production (GO:0032647)2.49877982
128regulation of nuclease activity (GO:0032069)2.49129200
129folic acid transport (GO:0015884)2.46830880
130neutrophil activation involved in immune response (GO:0002283)2.46563278
131collagen metabolic process (GO:0032963)2.46233388
132positive regulation of protein import into nucleus, translocation (GO:0033160)2.46129715
133cellular response to unfolded protein (GO:0034620)2.45585669
134mitotic nuclear envelope disassembly (GO:0007077)2.45549848
135detection of molecule of bacterial origin (GO:0032490)2.43460924
136heterochromatin organization (GO:0070828)2.39934406
137collagen catabolic process (GO:0030574)2.39381312
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37423400
139myeloid cell homeostasis (GO:0002262)2.36962186
140cellular response to topologically incorrect protein (GO:0035967)2.36438320
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.35681964
142macrophage activation involved in immune response (GO:0002281)2.35205642
143regulation of protein import into nucleus, translocation (GO:0033158)2.33744506
144B cell mediated immunity (GO:0019724)2.32185995
145regulation of gene silencing by RNA (GO:0060966)2.32185142
146regulation of posttranscriptional gene silencing (GO:0060147)2.32185142
147regulation of gene silencing by miRNA (GO:0060964)2.32185142
148hyaluronan catabolic process (GO:0030214)2.31996729
149peptidyl-proline hydroxylation (GO:0019511)2.31693607
150cellular response to vitamin D (GO:0071305)2.31240087
151nuclear envelope disassembly (GO:0051081)2.30364519
152membrane disassembly (GO:0030397)2.30364519
153regulation of cholesterol storage (GO:0010885)2.30223643
154L-alpha-amino acid transmembrane transport (GO:1902475)2.29769880
155natural killer cell mediated cytotoxicity (GO:0042267)2.29591128
156natural killer cell mediated immunity (GO:0002228)2.29591128
157negative regulation of interleukin-12 production (GO:0032695)2.29018699
158nuclear pore organization (GO:0006999)2.27935908
159mannose metabolic process (GO:0006013)2.25551983
160regulation of protein heterodimerization activity (GO:0043497)2.25388315
161positive regulation vascular endothelial growth factor production (GO:0010575)2.25330926
162vagina development (GO:0060068)2.24114263
163T cell apoptotic process (GO:0070231)2.23971728
164positive regulation of cell adhesion mediated by integrin (GO:0033630)2.23876059
165positive regulation of interferon-beta production (GO:0032728)2.23832512
166pinocytosis (GO:0006907)2.23648137
167ER-nucleus signaling pathway (GO:0006984)2.23294364
168multicellular organismal macromolecule metabolic process (GO:0044259)2.22006913
169negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.21282315
170COPII vesicle coating (GO:0048208)2.19650735
171positive regulation of p38MAPK cascade (GO:1900745)2.16756288
172nuclear pore complex assembly (GO:0051292)2.16633185
173positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16521735
174multicellular organismal catabolic process (GO:0044243)2.16391916
175extracellular matrix disassembly (GO:0022617)2.14965593
176formation of translation preinitiation complex (GO:0001731)2.14672497
177regulation of early endosome to late endosome transport (GO:2000641)2.14420843
178folic acid metabolic process (GO:0046655)2.13442846
179regulation of hippo signaling (GO:0035330)2.13319216
180multicellular organismal metabolic process (GO:0044236)2.13157232
181response to laminar fluid shear stress (GO:0034616)2.12811867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.46352024
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.94891221
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.67979016
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.14573817
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.88332347
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.85871383
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64108702
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63267636
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.58047136
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.47333897
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35468721
12VDR_24763502_ChIP-Seq_THP-1_Human2.25803356
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24715526
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16040425
15CLOCK_20551151_ChIP-Seq_293T_Human2.14979126
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03242456
17* TFEB_21752829_ChIP-Seq_HELA_Human2.01940065
18VDR_24787735_ChIP-Seq_THP-1_Human1.97198421
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96851092
20* SPI1_23127762_ChIP-Seq_K562_Human1.96433106
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93817876
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89802001
23* MYC_18555785_ChIP-Seq_MESCs_Mouse1.85312476
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84578772
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80226143
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76731113
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72470171
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71471635
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.71445294
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70181712
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69245166
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.69146255
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67639880
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67350281
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.66065612
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63777095
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63690816
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61364930
39AR_21909140_ChIP-Seq_LNCAP_Human1.61306729
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56381467
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54701066
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48905143
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48704923
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48231042
45MAF_26560356_Chip-Seq_TH1_Human1.47588069
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46966496
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46823347
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46321083
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45378550
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45275181
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43963250
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42153292
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42022480
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39197012
55* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38548334
56RUNX_20019798_ChIP-Seq_JUKART_Human1.37932163
57GATA1_22025678_ChIP-Seq_K562_Human1.37548898
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36833605
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34711511
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34566549
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34473156
62PU_27001747_Chip-Seq_BMDM_Mouse1.32312064
63* MYB_26560356_Chip-Seq_TH2_Human1.32003055
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31887684
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31771835
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31664919
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30678556
68* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30458331
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.30406822
70LXR_22292898_ChIP-Seq_THP-1_Human1.30306013
71ATF3_27146783_Chip-Seq_COLON_Human1.29897075
72* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29480583
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29302439
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28980818
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28195829
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26498602
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.26188232
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26140996
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25902800
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24735056
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.24350576
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24110004
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22763817
84MYC_22102868_ChIP-Seq_BL_Human1.22760774
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22559826
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22519584
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21785679
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20230004
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19675221
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19315763
91GATA1_19941826_ChIP-Seq_K562_Human1.19114616
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.18234529
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17307529
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.17147472
95SPI1_23547873_ChIP-Seq_NB4_Human1.16422912
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.16399364
97* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16147244
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15915749
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15560958
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15421132
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15298114
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15033382
103STAT1_20625510_ChIP-Seq_HELA_Human1.14442270
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14078323
105SCL_19346495_ChIP-Seq_HPC-7_Human1.13679156
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12831786
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12769689
108MYB_26560356_Chip-Seq_TH1_Human1.11460707
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11327842
110UTX_26944678_Chip-Seq_JUKART_Human1.10371666
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10297019
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09768389
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09768389
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09768389
115SOX2_20726797_ChIP-Seq_SW620_Human1.09726313
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09651821
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09592298
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09414817
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09122117
120BRD4_25478319_ChIP-Seq_HGPS_Human1.07912329
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07480323
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06706325
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06542567
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06534842
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06491218
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06491218
127GABP_17652178_ChIP-ChIP_JURKAT_Human1.05682322
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04981718
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04099154
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04041311
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03911299
132LXR_22158963_ChIP-Seq_LIVER_Mouse1.03303276
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03162593
134XRN2_22483619_ChIP-Seq_HELA_Human1.02959454
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02910371
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02733012
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01269709
138DCP1A_22483619_ChIP-Seq_HELA_Human1.01233094
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00611601
140SMAD_19615063_ChIP-ChIP_OVARY_Human1.00600114
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00209607
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99868221
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99617934
144RACK7_27058665_Chip-Seq_MCF-7_Human0.99309225
145* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98861468
146ELK1_19687146_ChIP-ChIP_HELA_Human0.98761817
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98521379
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98490400
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.98277269
150TCF7_22412390_ChIP-Seq_EML_Mouse0.98205002
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97840832
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97772504
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97745221
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96902401
155ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96500451
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95539987
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94962749
158SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94492171
159* GATA3_27048872_Chip-Seq_THYMUS_Human0.94200655
160VDR_21846776_ChIP-Seq_THP-1_Human0.93280241
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.91370034
162EST1_17652178_ChIP-ChIP_JURKAT_Human0.91096446
163KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90964578
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90078980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.57245824
2MP0003705_abnormal_hypodermis_morpholog3.78847688
3MP0003724_increased_susceptibility_to3.26723208
4MP0005275_abnormal_skin_tensile2.94415559
5MP0005058_abnormal_lysosome_morphology2.85646065
6MP0005503_abnormal_tendon_morphology2.79263166
7MP0005257_abnormal_intraocular_pressure2.51517741
8MP0002877_abnormal_melanocyte_morpholog2.46708002
9MP0005025_abnormal_response_to2.46382934
10MP0010352_gastrointestinal_tract_polyps2.29102190
11MP0003279_aneurysm2.25381398
12MP0005671_abnormal_response_to2.24305221
13MP0003566_abnormal_cell_adhesion2.21151117
14MP0010307_abnormal_tumor_latency2.08623890
15MP0003075_altered_response_to2.06569326
16MP0001958_emphysema2.06104188
17MP0001800_abnormal_humoral_immune1.94777820
18MP0002723_abnormal_immune_serum1.94449941
19MP0009840_abnormal_foam_cell1.92672361
20MP0000604_amyloidosis1.92399228
21MP0005023_abnormal_wound_healing1.89470751
22MP0005076_abnormal_cell_differentiation1.79800719
23MP0002420_abnormal_adaptive_immunity1.74777957
24MP0001819_abnormal_immune_cell1.74590064
25MP0008260_abnormal_autophagy1.70369423
26MP0003283_abnormal_digestive_organ1.68327591
27MP0010155_abnormal_intestine_physiology1.66352625
28MP0006054_spinal_hemorrhage1.64948571
29MP0005464_abnormal_platelet_physiology1.61477707
30MP0003828_pulmonary_edema1.61329071
31MP0003172_abnormal_lysosome_physiology1.61267875
32MP0003656_abnormal_erythrocyte_physiolo1.56765836
33MP0001835_abnormal_antigen_presentation1.56421189
34MP0003436_decreased_susceptibility_to1.55461761
35MP0009764_decreased_sensitivity_to1.53244869
36MP0008469_abnormal_protein_level1.51445027
37MP0005508_abnormal_skeleton_morphology1.48065711
38MP0003448_altered_tumor_morphology1.42785981
39MP0000858_altered_metastatic_potential1.41011777
40MP0005451_abnormal_body_composition1.40723280
41MP0003091_abnormal_cell_migration1.39725372
42MP0008004_abnormal_stomach_pH1.39494338
43MP0005166_decreased_susceptibility_to1.34920096
44MP0003690_abnormal_glial_cell1.34487364
45MP0001542_abnormal_bone_strength1.33965363
46MP0005310_abnormal_salivary_gland1.33939520
47MP0008007_abnormal_cellular_replicative1.33901413
48MP0001533_abnormal_skeleton_physiology1.33655917
49MP0002132_abnormal_respiratory_system1.31926011
50MP0004272_abnormal_basement_membrane1.29923152
51MP0003693_abnormal_embryo_hatching1.27053931
52MP0005390_skeleton_phenotype1.26010376
53MP0003183_abnormal_peptide_metabolism1.25785926
54MP0002139_abnormal_hepatobiliary_system1.24839227
55MP0002295_abnormal_pulmonary_circulatio1.22003434
56MP0009384_cardiac_valve_regurgitation1.21282578
57MP0004510_myositis1.21044577
58MP0002060_abnormal_skin_morphology1.20488151
59MP0000716_abnormal_immune_system1.18454555
60MP0010234_abnormal_vibrissa_follicle1.18164989
61* MP0005164_abnormal_response_to1.16982562
62MP0001243_abnormal_dermal_layer1.15970089
63MP0000685_abnormal_immune_system1.15674941
64MP0000733_abnormal_muscle_development1.15167244
65MP0006082_CNS_inflammation1.14869225
66MP0005165_increased_susceptibility_to1.14072804
67MP0005623_abnormal_meninges_morphology1.13511577
68MP0003111_abnormal_nucleus_morphology1.12339411
69MP0005397_hematopoietic_system_phenotyp1.11720103
70MP0001545_abnormal_hematopoietic_system1.11720103
71MP0003300_gastrointestinal_ulcer1.10017870
72MP0002933_joint_inflammation1.09589429
73MP0004957_abnormal_blastocyst_morpholog1.08157128
74MP0008875_abnormal_xenobiotic_pharmacok1.06722336
75MP0002419_abnormal_innate_immunity1.06308714
76MP0000465_gastrointestinal_hemorrhage1.03895544
77MP0002168_other_aberrant_phenotype1.02440624
78MP0003186_abnormal_redox_activity1.02097729
79MP0003077_abnormal_cell_cycle1.01993652
80MP0005408_hypopigmentation1.01914264
81MP0002998_abnormal_bone_remodeling1.01898270
82MP0000371_diluted_coat_color1.01804171
83MP0009053_abnormal_anal_canal1.01004743
84MP0009763_increased_sensitivity_to0.99903407
85MP0001851_eye_inflammation0.99571796
86MP0003329_amyloid_beta_deposits0.98268800
87MP0000767_abnormal_smooth_muscle0.95295285
88MP0003303_peritoneal_inflammation0.95261215
89MP0004947_skin_inflammation0.94252237
90MP0002398_abnormal_bone_marrow0.93638088
91MP0000343_altered_response_to0.92870183
92MP0002896_abnormal_bone_mineralization0.92271058
93MP0009333_abnormal_splenocyte_physiolog0.92239964
94MP0010030_abnormal_orbit_morphology0.92150129
95MP0002277_abnormal_respiratory_mucosa0.92148340
96MP0000689_abnormal_spleen_morphology0.91669518
97MP0002429_abnormal_blood_cell0.91560438
98MP0000350_abnormal_cell_proliferation0.91178325
99MP0003795_abnormal_bone_structure0.90396719
100MP0003806_abnormal_nucleotide_metabolis0.90225445
101MP0005000_abnormal_immune_tolerance0.89617104
102MP0005365_abnormal_bile_salt0.89545350
103MP0005387_immune_system_phenotype0.88768886
104MP0001790_abnormal_immune_system0.88768886
105MP0002148_abnormal_hypersensitivity_rea0.88418532
106MP0000920_abnormal_myelination0.87828258
107MP0003453_abnormal_keratinocyte_physiol0.87695763
108MP0001849_ear_inflammation0.86798553
109MP0001915_intracranial_hemorrhage0.86726843
110MP0009278_abnormal_bone_marrow0.85438640
111MP0002452_abnormal_antigen_presenting0.85331092
112* MP0004883_abnormal_blood_vessel0.84305024
113MP0003195_calcinosis0.81515652
114MP0002722_abnormal_immune_system0.81374651
115MP0005621_abnormal_cell_physiology0.79772253
116MP0005395_other_phenotype0.78306605
117MP0004019_abnormal_vitamin_homeostasis0.78267356
118MP0002166_altered_tumor_susceptibility0.76333033
119MP0000428_abnormal_craniofacial_morphol0.75792195
120MP0002115_abnormal_skeleton_extremities0.74995268
121MP0002138_abnormal_hepatobiliary_system0.74769769
122MP0009765_abnormal_xenobiotic_induced0.73014858
123MP0005197_abnormal_uvea_morphology0.72171648
124MP0003045_fibrosis0.71684509
125MP0010094_abnormal_chromosome_stability0.71320235
126MP0005167_abnormal_blood-brain_barrier0.70938653
127MP0003191_abnormal_cellular_cholesterol0.70646713
128MP0004197_abnormal_fetal_growth/weight/0.70593436
129MP0002113_abnormal_skeleton_development0.69586669
130MP0001730_embryonic_growth_arrest0.69419166
131MP0000627_abnormal_mammary_gland0.68347254
132MP0002282_abnormal_trachea_morphology0.67480513
133MP0005319_abnormal_enzyme/_coenzyme0.67308158
134MP0002405_respiratory_system_inflammati0.66849669
135MP0000598_abnormal_liver_morphology0.66698793
136MP0001348_abnormal_lacrimal_gland0.66583714
137MP0002254_reproductive_system_inflammat0.65992560
138MP0001845_abnormal_inflammatory_respons0.65966259
139MP0002086_abnormal_extraembryonic_tissu0.65416344
140MP0002111_abnormal_tail_morphology0.65157018
141* MP0000249_abnormal_blood_vessel0.64497322
142MP0010678_abnormal_skin_adnexa0.64434294
143MP0002135_abnormal_kidney_morphology0.64068679
144MP0000163_abnormal_cartilage_morphology0.64037902
145MP0001175_abnormal_lung_morphology0.63624669
146MP0001216_abnormal_epidermal_layer0.63577190
147MP0000490_abnormal_crypts_of0.63567388
148MP0003763_abnormal_thymus_physiology0.63471958
149MP0009785_altered_susceptibility_to0.62378526
150MP0005384_cellular_phenotype0.62143847
151MP0000569_abnormal_digit_pigmentation0.62135131
152MP0009643_abnormal_urine_homeostasis0.61823789
153MP0001853_heart_inflammation0.61581438
154MP0008932_abnormal_embryonic_tissue0.61444970
155MP0003866_abnormal_defecation0.60269805
156MP0001663_abnormal_digestive_system0.60196361
157MP0002136_abnormal_kidney_physiology0.59717261

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.00243523
2Premature rupture of membranes (HP:0001788)5.83056576
3Cervical subluxation (HP:0003308)4.66587352
4Vertebral compression fractures (HP:0002953)4.35653212
5Peritonitis (HP:0002586)4.35541968
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.30163988
7Loss of speech (HP:0002371)3.84880831
8Recurrent gram-negative bacterial infections (HP:0005420)3.84155924
9Ankle contracture (HP:0006466)3.83205537
10Abnormal respiratory epithelium morphology (HP:0012253)3.78977735
11Abnormal respiratory motile cilium morphology (HP:0005938)3.78977735
12Abnormal respiratory motile cilium physiology (HP:0012261)3.67984623
13Absent/shortened dynein arms (HP:0200106)3.64188008
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.64188008
15Abnormal ciliary motility (HP:0012262)3.59718138
16Nasal polyposis (HP:0100582)3.59065890
17Abnormality of the nasal mucosa (HP:0000433)3.46147944
18Rhinitis (HP:0012384)3.39923000
19Vacuolated lymphocytes (HP:0001922)3.36296475
20Dysostosis multiplex (HP:0000943)3.34586218
21Soft skin (HP:0000977)3.27343557
22Cerebral aneurysm (HP:0004944)3.25220160
23Shallow orbits (HP:0000586)3.12665427
24Increased cerebral lipofuscin (HP:0011813)3.08259851
25Urinary glycosaminoglycan excretion (HP:0003541)3.07950074
26Mucopolysacchariduria (HP:0008155)3.07950074
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.99634986
28Osteolytic defects of the hand bones (HP:0009699)2.99634986
29Amyloidosis (HP:0011034)2.96570939
30Aortic dissection (HP:0002647)2.94966033
31Chronic bronchitis (HP:0004469)2.94895448
32Disinhibition (HP:0000734)2.94229823
33Mediastinal lymphadenopathy (HP:0100721)2.92073879
34Aortic aneurysm (HP:0004942)2.92043797
35Bronchiectasis (HP:0002110)2.89725351
36Biconcave vertebral bodies (HP:0004586)2.88595872
37Recurrent skin infections (HP:0001581)2.88509952
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87894209
39Abnormality of polysaccharide metabolism (HP:0011012)2.87894209
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87894209
41Blue sclerae (HP:0000592)2.80910502
42Abnormality of glycolipid metabolism (HP:0010969)2.77678301
43Abnormality of liposaccharide metabolism (HP:0010968)2.77678301
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.77678301
45Dilatation of the ascending aorta (HP:0005111)2.75475400
46Systemic lupus erythematosus (HP:0002725)2.72167345
47Stomatitis (HP:0010280)2.71139345
48Wormian bones (HP:0002645)2.64373144
49Recurrent sinusitis (HP:0011108)2.63970144
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.61681408
51Nuclear cataract (HP:0100018)2.59519104
52Spondylolisthesis (HP:0003302)2.57482429
53Purpura (HP:0000979)2.57370637
54Glomerulonephritis (HP:0000099)2.55825834
55Gingivitis (HP:0000230)2.54663655
56Interstitial pulmonary disease (HP:0006530)2.52192299
57Genu recurvatum (HP:0002816)2.48521099
58Beaking of vertebral bodies (HP:0004568)2.48051647
59Abnormality of the acetabulum (HP:0003170)2.47789052
60Neurofibrillary tangles (HP:0002185)2.45986805
61Obstructive lung disease (HP:0006536)2.43847174
62Chronic obstructive pulmonary disease (HP:0006510)2.43847174
63Joint stiffness (HP:0001387)2.41182466
64Abnormality of dentin (HP:0010299)2.40119837
65Wrist flexion contracture (HP:0001239)2.38677134
66Abnormality of the anterior horn cell (HP:0006802)2.38478378
67Degeneration of anterior horn cells (HP:0002398)2.38478378
68Myocardial infarction (HP:0001658)2.35989446
69Increased serum ferritin (HP:0003281)2.35625417
70Spinal muscular atrophy (HP:0007269)2.31262434
71Hepatosplenomegaly (HP:0001433)2.30486802
72Bladder diverticulum (HP:0000015)2.30395629
73Urticaria (HP:0001025)2.29953735
74Bronchitis (HP:0012387)2.28515507
75Hand muscle atrophy (HP:0009130)2.27764840
76Progressive neurologic deterioration (HP:0002344)2.27431062
77Pulmonary infiltrates (HP:0002113)2.25584830
78Breech presentation (HP:0001623)2.25440746
79Short nail (HP:0001799)2.24827969
80Recurrent fungal infections (HP:0002841)2.23989247
81Axonal loss (HP:0003447)2.23548587
82Neonatal short-limb short stature (HP:0008921)2.23209492
83Autoimmune thrombocytopenia (HP:0001973)2.23141279
84Atrophic scars (HP:0001075)2.23025048
85Malnutrition (HP:0004395)2.22493842
86Orchitis (HP:0100796)2.21023204
87Abnormal delivery (HP:0001787)2.20132083
88Chronic mucocutaneous candidiasis (HP:0002728)2.20062323
89Recurrent cutaneous fungal infections (HP:0011370)2.20062323
90Premature loss of primary teeth (HP:0006323)2.19901980
91Vascular tortuosity (HP:0004948)2.19083281
92Abnormality of the peritoneum (HP:0002585)2.12640731
93Thin bony cortex (HP:0002753)2.12553256
94Follicular hyperkeratosis (HP:0007502)2.11026788
95Chronic otitis media (HP:0000389)2.10674590
96Metaphyseal cupping (HP:0003021)2.08490386
97Mutism (HP:0002300)2.06887012
98Vasculitis (HP:0002633)2.05033627
99Thick nail (HP:0001805)2.05012645
100Keratoconjunctivitis sicca (HP:0001097)2.05003461
101Hemoptysis (HP:0002105)2.04507901
102Meningitis (HP:0001287)2.03069398
103Broad metatarsal (HP:0001783)2.02776310
104Ulnar bowing (HP:0003031)2.01389213
105Hematochezia (HP:0002573)2.00915382
106Myositis (HP:0100614)2.00027588
107Complement deficiency (HP:0004431)1.98823003
108Neuronal loss in central nervous system (HP:0002529)1.97211645
109Abnormality of the odontoid process (HP:0003310)1.97067267
110Distal upper limb amyotrophy (HP:0007149)1.96433971
111Upper limb amyotrophy (HP:0009129)1.96433971
112Platyspondyly (HP:0000926)1.95941734
113Abnormality of the distal phalanges of the toes (HP:0010182)1.95920961
114Asymmetric septal hypertrophy (HP:0001670)1.95781134
115Ovoid vertebral bodies (HP:0003300)1.94965066
116Chronic sinusitis (HP:0011109)1.94812950
117Recurrent otitis media (HP:0000403)1.94666877
118Poor head control (HP:0002421)1.94291439
119Recurrent abscess formation (HP:0002722)1.93595947
120Recurrent viral infections (HP:0004429)1.92637732
121Coxa vara (HP:0002812)1.92518579
122Nonimmune hydrops fetalis (HP:0001790)1.92198757
123Abnormality of iron homeostasis (HP:0011031)1.91726327
124Abnormality of complement system (HP:0005339)1.91549082
125Elevated erythrocyte sedimentation rate (HP:0003565)1.91239340
126Petechiae (HP:0000967)1.90600593
127Increased CSF protein (HP:0002922)1.90315524
128Mitral valve prolapse (HP:0001634)1.88741322
129Abnormality of skull ossification (HP:0002703)1.88341143
130Tetraparesis (HP:0002273)1.88039536
131Diminished motivation (HP:0000745)1.87073124
132Pathologic fracture (HP:0002756)1.86867143
133Apathy (HP:0000741)1.85808475
134Abnormality of macrophages (HP:0004311)1.85588139
135Aneurysm (HP:0002617)1.85220625
136Basal ganglia calcification (HP:0002135)1.84063266
137Recurrent bronchitis (HP:0002837)1.82879298
138Keratoconjunctivitis (HP:0001096)1.82379888
139Syringomyelia (HP:0003396)1.80375662
140Spinal cord lesions (HP:0100561)1.80375662
141Restrictive lung disease (HP:0002091)1.79652162
142Cerebral inclusion bodies (HP:0100314)1.79084546
143Eczematoid dermatitis (HP:0000976)1.78797672
144Spinal rigidity (HP:0003306)1.78299269
145Cupped ribs (HP:0000887)1.78002064
146Fragile skin (HP:0001030)1.77878981
147Hypoplasia of the odontoid process (HP:0003311)1.77558969
148Selective tooth agenesis (HP:0001592)1.76772269
149Elbow flexion contracture (HP:0002987)1.75730976
150Abnormality of proline metabolism (HP:0010907)1.75211694
151Hydroxyprolinuria (HP:0003080)1.75211694
152Alopecia of scalp (HP:0002293)1.74703539
153Pustule (HP:0200039)1.74166210
154Spontaneous hematomas (HP:0007420)1.74103275
155Gastrointestinal infarctions (HP:0005244)1.74013651
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73709988
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73077262
158Vertebral hypoplasia (HP:0008417)1.73077262
159Polyneuropathy (HP:0001271)1.71880785
160Arterial tortuosity (HP:0005116)1.70926439
161Upper motor neuron abnormality (HP:0002127)1.70240589
162Abnormal cartilage morphology (HP:0002763)1.69795603
163Hypergammaglobulinemia (HP:0010702)1.69661163
164Recurrent bacterial skin infections (HP:0005406)1.69186072
165Osteomyelitis (HP:0002754)1.68833782
166Thoracic kyphosis (HP:0002942)1.68628133
167Severe short stature (HP:0003510)1.68304700
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68223069
169Hyperextensible skin (HP:0000974)1.66510521
170Joint laxity (HP:0001388)1.65525396
171Slender long bone (HP:0003100)1.63753125
172Camptodactyly of toe (HP:0001836)1.63331738
173Agnosia (HP:0010524)1.63256773
174Optic neuritis (HP:0100653)1.62965808
175Retrobulbar optic neuritis (HP:0100654)1.62965808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.83598512
2ERN13.40760080
3TRIB32.70626321
4DDR22.40459419
5PRPF4B2.27202556
6EPHA22.17779837
7MAPK152.10664313
8PKN21.97016276
9MATK1.93557616
10RPS6KA41.93037611
11FGR1.91863659
12GRK71.90310521
13PDGFRA1.87505882
14PIM21.83141467
15CDK121.80374326
16FLT31.79613137
17TTN1.68339201
18NME21.63177701
19STK38L1.62112403
20BMPR21.60268251
21STK31.58912443
22TBK11.56301814
23LATS11.55725432
24MAP3K141.54247178
25MAP4K11.53510428
26NEK91.52623035
27WEE11.52472002
28MAP3K131.51973666
29PASK1.50206090
30MST41.49464600
31BMX1.48812507
32PAK41.47422238
33IRAK31.46140738
34IKBKE1.45379707
35BRSK21.45026936
36MET1.45013164
37TAOK31.43358370
38NEK21.42283303
39FES1.41121001
40TAOK21.41038234
41BUB11.40368211
42TAOK11.38851599
43IKBKB1.38414024
44CHUK1.32873393
45TYK21.31340305
46SCYL21.30914876
47TESK11.27724086
48MAP3K111.26026248
49LATS21.25228237
50EPHB11.24243483
51NEK11.23892924
52KIT1.21606783
53EPHA31.20521984
54CDC42BPA1.20276388
55JAK31.19048651
56STK101.19019309
57LYN1.17680955
58TTK1.15161664
59MAP3K21.14849257
60MAP3K11.12700775
61LRRK21.12138271
62MAP3K31.10639978
63MST1R1.10328272
64FGFR41.09903974
65SYK1.09052527
66PTK21.08546278
67STK241.08003520
68PIM11.07970846
69GRK61.06955397
70MAP3K81.05860801
71TGFBR21.05034525
72SIK11.03941465
73HCK0.99328490
74RIPK10.98962959
75TRPM70.98809598
76TESK20.98214035
77BTK0.97495275
78JAK20.97043874
79IRAK10.95122633
80PTK60.94784419
81SIK30.93243414
82CDK60.92737369
83PLK10.87798857
84EIF2AK10.85981605
85ACVR1B0.85789448
86CDK70.85611635
87SMG10.84577479
88PAK20.82617910
89MTOR0.81425336
90ERBB30.80935873
91MAP2K30.80660387
92EEF2K0.80502634
93ARAF0.78934311
94ABL20.78203316
95TXK0.78180995
96MOS0.78052653
97PDPK10.77905017
98LCK0.77508945
99BLK0.76854187
100JAK10.76693495
101KSR20.72729891
102ZAP700.72284064
103IRAK20.71511157
104YES10.71497638
105EIF2AK30.70321640
106AURKB0.70245330
107TGFBR10.69732377
108MAPK70.69520187
109CSF1R0.69120818
110PLK30.68458037
111TNK20.68351599
112MARK30.66332393
113EPHB20.65762543
114CAMKK20.64976928
115BRSK10.63296972
116DYRK1B0.61254014
117PBK0.60170869
118MAP3K100.59503663
119TEC0.58836358
120MAP3K50.58236783
121ITK0.57643183
122ZAK0.57594687
123FER0.55961650
124MELK0.55667195
125PDK10.54995687
126STK40.54633964
127ATR0.54593618
128MAPKAPK30.54457998
129CHEK20.54030374
130MAP3K60.53881721
131CDC70.53552166
132MAPKAPK20.52659318
133DYRK30.51739292
134CAMK1D0.51707084
135PAK10.50254683
136ABL10.49582510
137CDK40.49413631
138PRKCD0.48872678
139BRAF0.48054668
140CSK0.47085557
141IRAK40.46853125
142FGFR10.46198651
143FGFR30.44403422
144PLK40.44162961
145FYN0.44127596
146EIF2AK20.42529022
147PTK2B0.42379089
148MARK20.41628063
149MAPK120.41279723
150PDGFRB0.40581648
151PDK20.39175865
152PRKD20.38963646
153RPS6KA20.36592779
154MAP2K60.36555084

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.02635139
2Lysosome_Homo sapiens_hsa041422.85746572
3Autoimmune thyroid disease_Homo sapiens_hsa053202.51249034
4Asthma_Homo sapiens_hsa053102.51074240
5Other glycan degradation_Homo sapiens_hsa005112.38651642
6Type I diabetes mellitus_Homo sapiens_hsa049402.07938318
7p53 signaling pathway_Homo sapiens_hsa041151.99199257
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97737140
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96048142
10One carbon pool by folate_Homo sapiens_hsa006701.90103965
11Antigen processing and presentation_Homo sapiens_hsa046121.85434317
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83512355
13Legionellosis_Homo sapiens_hsa051341.72906999
14Staphylococcus aureus infection_Homo sapiens_hsa051501.69990191
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61043229
16Hematopoietic cell lineage_Homo sapiens_hsa046401.60441345
17Malaria_Homo sapiens_hsa051441.54471800
18Cell cycle_Homo sapiens_hsa041101.50527410
19Leishmaniasis_Homo sapiens_hsa051401.49732313
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47338041
21Apoptosis_Homo sapiens_hsa042101.43771867
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.40710317
23ECM-receptor interaction_Homo sapiens_hsa045121.37828845
24Small cell lung cancer_Homo sapiens_hsa052221.34545000
25Phagosome_Homo sapiens_hsa041451.33606969
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31114248
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24541166
28B cell receptor signaling pathway_Homo sapiens_hsa046621.21478147
29Bladder cancer_Homo sapiens_hsa052191.21475087
30Collecting duct acid secretion_Homo sapiens_hsa049661.18364511
31Sphingolipid metabolism_Homo sapiens_hsa006001.18225687
32DNA replication_Homo sapiens_hsa030301.18092014
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15923171
34Tuberculosis_Homo sapiens_hsa051521.12927675
35RNA transport_Homo sapiens_hsa030131.12268454
36Chronic myeloid leukemia_Homo sapiens_hsa052201.11050318
37MicroRNAs in cancer_Homo sapiens_hsa052061.10676160
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09353563
39Shigellosis_Homo sapiens_hsa051311.08443003
40Proteoglycans in cancer_Homo sapiens_hsa052051.08219970
41Proteasome_Homo sapiens_hsa030501.05301365
42Galactose metabolism_Homo sapiens_hsa000521.05199157
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05110814
44Base excision repair_Homo sapiens_hsa034101.03689943
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03296311
46Viral carcinogenesis_Homo sapiens_hsa052031.02964784
47Focal adhesion_Homo sapiens_hsa045101.02790103
48Toxoplasmosis_Homo sapiens_hsa051451.02194752
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02004631
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01815144
51Pertussis_Homo sapiens_hsa051331.01532376
52Chemokine signaling pathway_Homo sapiens_hsa040621.01406116
53TNF signaling pathway_Homo sapiens_hsa046681.01094292
54Hepatitis C_Homo sapiens_hsa051601.00940389
55Selenocompound metabolism_Homo sapiens_hsa004500.99370917
56Adherens junction_Homo sapiens_hsa045200.99182793
57Osteoclast differentiation_Homo sapiens_hsa043800.98541901
58Folate biosynthesis_Homo sapiens_hsa007900.95644048
59Amoebiasis_Homo sapiens_hsa051460.94232058
60Mismatch repair_Homo sapiens_hsa034300.92874742
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91569744
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90772420
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90679573
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90075060
65Complement and coagulation cascades_Homo sapiens_hsa046100.89854660
66Epstein-Barr virus infection_Homo sapiens_hsa051690.88965469
67Measles_Homo sapiens_hsa051620.88332213
68TGF-beta signaling pathway_Homo sapiens_hsa043500.86559945
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.86387259
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86062556
71Herpes simplex infection_Homo sapiens_hsa051680.84058260
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82438952
73African trypanosomiasis_Homo sapiens_hsa051430.81007431
74Hepatitis B_Homo sapiens_hsa051610.80237222
75Pancreatic cancer_Homo sapiens_hsa052120.79791570
76N-Glycan biosynthesis_Homo sapiens_hsa005100.77798896
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.76194410
78Viral myocarditis_Homo sapiens_hsa054160.75569574
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75319293
80HTLV-I infection_Homo sapiens_hsa051660.74530703
81Influenza A_Homo sapiens_hsa051640.73479037
82Rheumatoid arthritis_Homo sapiens_hsa053230.73369958
83Acute myeloid leukemia_Homo sapiens_hsa052210.72667826
84Vibrio cholerae infection_Homo sapiens_hsa051100.70945244
85Caffeine metabolism_Homo sapiens_hsa002320.69663928
86Renin-angiotensin system_Homo sapiens_hsa046140.68695700
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.67846665
88Histidine metabolism_Homo sapiens_hsa003400.67498057
89Protein export_Homo sapiens_hsa030600.63734140
90Prostate cancer_Homo sapiens_hsa052150.63312184
91HIF-1 signaling pathway_Homo sapiens_hsa040660.62716129
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.62278854
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60724027
94Hippo signaling pathway_Homo sapiens_hsa043900.60207601
95Nucleotide excision repair_Homo sapiens_hsa034200.59694148
96Prion diseases_Homo sapiens_hsa050200.59282829
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58617140
98Fructose and mannose metabolism_Homo sapiens_hsa000510.58168410
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57851750
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56623768
101Primary immunodeficiency_Homo sapiens_hsa053400.56487512
102Protein digestion and absorption_Homo sapiens_hsa049740.56279013
103Pentose phosphate pathway_Homo sapiens_hsa000300.56228965
104Graft-versus-host disease_Homo sapiens_hsa053320.53715460
105Biosynthesis of amino acids_Homo sapiens_hsa012300.52875013
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52246409
107Notch signaling pathway_Homo sapiens_hsa043300.51350452
108T cell receptor signaling pathway_Homo sapiens_hsa046600.51275598
109Melanoma_Homo sapiens_hsa052180.50758609
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.50059131
111Sulfur metabolism_Homo sapiens_hsa009200.49972349
112Salmonella infection_Homo sapiens_hsa051320.49630125
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48175003
114Homologous recombination_Homo sapiens_hsa034400.48060494
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47417382
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.47094833
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46933607
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46870726
119Glutathione metabolism_Homo sapiens_hsa004800.45479813
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45164411
121Arginine and proline metabolism_Homo sapiens_hsa003300.44974707
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.44436699
123Endocytosis_Homo sapiens_hsa041440.42794816
124Steroid biosynthesis_Homo sapiens_hsa001000.42645059
125Pyrimidine metabolism_Homo sapiens_hsa002400.42225827
126PPAR signaling pathway_Homo sapiens_hsa033200.41860832
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.41406779
128Allograft rejection_Homo sapiens_hsa053300.40196552
129mTOR signaling pathway_Homo sapiens_hsa041500.39924457
130Mineral absorption_Homo sapiens_hsa049780.35661864
131Chemical carcinogenesis_Homo sapiens_hsa052040.35563233
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.34049712
133Phenylalanine metabolism_Homo sapiens_hsa003600.32923650
134Prolactin signaling pathway_Homo sapiens_hsa049170.32386564
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.30751343
136Platelet activation_Homo sapiens_hsa046110.30595613
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24354671
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24243421
139VEGF signaling pathway_Homo sapiens_hsa043700.23569403
140Arachidonic acid metabolism_Homo sapiens_hsa005900.23053721
141Insulin resistance_Homo sapiens_hsa049310.21642232

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