SCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.23906942
2L-phenylalanine catabolic process (GO:0006559)7.23906942
3exogenous drug catabolic process (GO:0042738)7.18888803
4L-phenylalanine metabolic process (GO:0006558)6.92121537
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.92121537
6epoxygenase P450 pathway (GO:0019373)6.70237911
7aromatic amino acid family catabolic process (GO:0009074)6.51426473
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.95031850
9tryptophan catabolic process (GO:0006569)5.87623326
10indole-containing compound catabolic process (GO:0042436)5.87623326
11indolalkylamine catabolic process (GO:0046218)5.87623326
12glyoxylate metabolic process (GO:0046487)5.73118018
13kynurenine metabolic process (GO:0070189)5.71901479
14omega-hydroxylase P450 pathway (GO:0097267)5.63645756
15* bile acid biosynthetic process (GO:0006699)5.56071671
16tryptophan metabolic process (GO:0006568)5.53556843
17cysteine metabolic process (GO:0006534)5.30480697
18urea metabolic process (GO:0019627)5.29924052
19urea cycle (GO:0000050)5.29924052
20* alpha-linolenic acid metabolic process (GO:0036109)5.24348270
21sulfur amino acid catabolic process (GO:0000098)5.21090463
22complement activation, alternative pathway (GO:0006957)5.19572505
23drug metabolic process (GO:0017144)5.14803333
24high-density lipoprotein particle remodeling (GO:0034375)5.05834720
25negative regulation of fibrinolysis (GO:0051918)5.02971534
26regulation of protein activation cascade (GO:2000257)5.00162377
27protein carboxylation (GO:0018214)4.97772665
28peptidyl-glutamic acid carboxylation (GO:0017187)4.97772665
29nitrogen cycle metabolic process (GO:0071941)4.90225415
30regulation of fibrinolysis (GO:0051917)4.86068378
31regulation of triglyceride catabolic process (GO:0010896)4.84832371
32serine family amino acid catabolic process (GO:0009071)4.81861148
33lysine metabolic process (GO:0006553)4.81482803
34lysine catabolic process (GO:0006554)4.81482803
35phenylpropanoid metabolic process (GO:0009698)4.75032372
36* bile acid metabolic process (GO:0008206)4.72989396
37aromatic amino acid family metabolic process (GO:0009072)4.72500544
38regulation of complement activation (GO:0030449)4.70410443
39* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68838516
40homocysteine metabolic process (GO:0050667)4.65426700
41amino-acid betaine metabolic process (GO:0006577)4.59804346
42tyrosine metabolic process (GO:0006570)4.54168946
43regulation of cholesterol esterification (GO:0010872)4.53685019
44ethanol metabolic process (GO:0006067)4.52223025
45alpha-amino acid catabolic process (GO:1901606)4.47316419
46triglyceride homeostasis (GO:0070328)4.46949310
47acylglycerol homeostasis (GO:0055090)4.46949310
48reverse cholesterol transport (GO:0043691)4.46207911
49plasma lipoprotein particle remodeling (GO:0034369)4.44552882
50protein-lipid complex remodeling (GO:0034368)4.44552882
51macromolecular complex remodeling (GO:0034367)4.44552882
52cellular ketone body metabolic process (GO:0046950)4.41357819
53fat-soluble vitamin biosynthetic process (GO:0042362)4.36256605
54phospholipid efflux (GO:0033700)4.30306266
55plasma lipoprotein particle clearance (GO:0034381)4.29471292
56coenzyme catabolic process (GO:0009109)4.27501846
57negative regulation of cholesterol transport (GO:0032375)4.19285613
58negative regulation of sterol transport (GO:0032372)4.19285613
59cellular amino acid catabolic process (GO:0009063)4.18057337
60oxidative demethylation (GO:0070989)4.17637267
61blood coagulation, intrinsic pathway (GO:0007597)4.16442509
62indolalkylamine metabolic process (GO:0006586)4.16346153
63ethanol oxidation (GO:0006069)4.16311222
64bile acid and bile salt transport (GO:0015721)4.09607399
65cellular glucuronidation (GO:0052695)4.09273446
66amine catabolic process (GO:0009310)4.07091036
67cellular biogenic amine catabolic process (GO:0042402)4.07091036
68xenobiotic catabolic process (GO:0042178)4.02873367
69serine family amino acid metabolic process (GO:0009069)4.01566422
70glutamate metabolic process (GO:0006536)4.00538985
71S-adenosylmethionine metabolic process (GO:0046500)4.00418013
72acetyl-CoA metabolic process (GO:0006084)3.99752615
73benzene-containing compound metabolic process (GO:0042537)3.99152815
74glycine metabolic process (GO:0006544)3.98828752
75cholesterol efflux (GO:0033344)3.95863550
76short-chain fatty acid metabolic process (GO:0046459)3.93365403
77cellular modified amino acid catabolic process (GO:0042219)3.92571099
78aldehyde catabolic process (GO:0046185)3.89356076
79imidazole-containing compound metabolic process (GO:0052803)3.85405529
80ketone body metabolic process (GO:1902224)3.81738927
81drug catabolic process (GO:0042737)3.79679531
82negative regulation of blood coagulation (GO:0030195)3.79004251
83negative regulation of hemostasis (GO:1900047)3.79004251
84serine family amino acid biosynthetic process (GO:0009070)3.78023296
85positive regulation of lipid catabolic process (GO:0050996)3.77345382
86* carboxylic acid catabolic process (GO:0046395)3.76737221
87* organic acid catabolic process (GO:0016054)3.76737221
88plasma lipoprotein particle assembly (GO:0034377)3.76413182
89positive regulation of lipoprotein lipase activity (GO:0051006)3.74055889
90positive regulation of triglyceride lipase activity (GO:0061365)3.74055889
91dicarboxylic acid biosynthetic process (GO:0043650)3.73075855
92* fatty acid beta-oxidation (GO:0006635)3.72038816
93arginine metabolic process (GO:0006525)3.71105344
94negative regulation of protein activation cascade (GO:2000258)3.69838488
95* fatty acid oxidation (GO:0019395)3.69207967
96glucuronate metabolic process (GO:0019585)3.69043939
97uronic acid metabolic process (GO:0006063)3.69043939
98low-density lipoprotein particle remodeling (GO:0034374)3.68045434
99phospholipid homeostasis (GO:0055091)3.67625065
100fibrinolysis (GO:0042730)3.67197351
101cytolysis (GO:0019835)3.64951493
102cofactor catabolic process (GO:0051187)3.63159994
1032-oxoglutarate metabolic process (GO:0006103)3.62913884
104cholesterol homeostasis (GO:0042632)3.62598451
105negative regulation of lipase activity (GO:0060192)3.62564244
106* lipid oxidation (GO:0034440)3.62347871
107very-low-density lipoprotein particle assembly (GO:0034379)3.62194990
108* monocarboxylic acid catabolic process (GO:0072329)3.61860279
109polyketide metabolic process (GO:0030638)3.61634296
110doxorubicin metabolic process (GO:0044598)3.61634296
111daunorubicin metabolic process (GO:0044597)3.61634296
112negative regulation of coagulation (GO:0050819)3.60585600
113aspartate family amino acid catabolic process (GO:0009068)3.58787618
114* fatty acid catabolic process (GO:0009062)3.58706845
115drug transmembrane transport (GO:0006855)3.57890953
116sterol homeostasis (GO:0055092)3.57280522
117hormone catabolic process (GO:0042447)3.56464698
118valine metabolic process (GO:0006573)3.55445534
119alkaloid metabolic process (GO:0009820)3.54896254
120positive regulation of fatty acid beta-oxidation (GO:0032000)3.54376342
121primary alcohol catabolic process (GO:0034310)3.52455679
122primary alcohol metabolic process (GO:0034308)3.49332506
123protein activation cascade (GO:0072376)3.46241575
124xenobiotic metabolic process (GO:0006805)3.46068369
125flavonoid metabolic process (GO:0009812)3.44904292
126negative regulation of wound healing (GO:0061045)3.36771781
127regulation of plasminogen activation (GO:0010755)3.32900054
128negative regulation of complement activation (GO:0045916)3.32339806
129complement activation, classical pathway (GO:0006958)3.29657060
130carnitine metabolic process (GO:0009437)3.23241004
131aminoglycoside antibiotic metabolic process (GO:0030647)3.22991098
132complement activation (GO:0006956)3.22877733
133heme transport (GO:0015886)3.19841385
134vitamin biosynthetic process (GO:0009110)3.17523549
135intestinal cholesterol absorption (GO:0030299)3.15592119
136NADH metabolic process (GO:0006734)3.14038098
137positive regulation of hemostasis (GO:1900048)3.11478980
138positive regulation of blood coagulation (GO:0030194)3.11478980
139intestinal absorption (GO:0050892)3.10850361
140L-methionine salvage (GO:0071267)3.07806479
141L-methionine biosynthetic process (GO:0071265)3.07806479
142amino acid salvage (GO:0043102)3.07806479
143regulation of humoral immune response (GO:0002920)3.01374732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.98682035
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.90743153
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.60098857
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.25163316
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.82394249
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92457754
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81446391
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83059056
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76384645
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51742486
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26612615
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06780498
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00630975
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3437429
15CLOCK_20551151_ChIP-Seq_293T_Human1.89588686
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83898385
17GATA1_22025678_ChIP-Seq_K562_Human1.70165654
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.69870145
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.56645245
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.54051012
21HTT_18923047_ChIP-ChIP_STHdh_Human1.48242002
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46658898
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34391838
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33512404
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32349642
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.30347193
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.29873850
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.22584111
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19452432
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19417913
31FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18290687
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16751142
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16600967
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15095778
35CJUN_26792858_Chip-Seq_BT549_Human1.14522230
36* HNFA_21074721_ChIP-Seq_CACO-2_Human1.11896147
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10564433
38* PHF8_20622853_ChIP-Seq_HELA_Human1.10127706
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09737724
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09216769
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09077884
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08957044
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07945471
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.07420225
45P53_22387025_ChIP-Seq_ESCs_Mouse1.05596788
46* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05549846
47* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03863432
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.03835071
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03517082
50NANOG_19829295_ChIP-Seq_ESCs_Human1.03145703
51SOX2_19829295_ChIP-Seq_ESCs_Human1.03145703
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01167868
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00524531
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.00236693
55SOX2_18555785_Chip-Seq_ESCs_Mouse0.99528162
56FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99289595
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98767282
58STAT3_18555785_Chip-Seq_ESCs_Mouse0.98415141
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97831686
60FOXA1_25329375_ChIP-Seq_VCAP_Human0.97689061
61FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97689061
62TP53_18474530_ChIP-ChIP_U2OS_Human0.97284836
63ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96648803
64IGF1R_20145208_ChIP-Seq_DFB_Human0.96592877
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95107119
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94911195
67* GATA6_21074721_ChIP-Seq_CACO-2_Human0.94815056
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94742582
69IRF8_21731497_ChIP-ChIP_J774_Mouse0.94514207
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94315622
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94122272
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.93745549
73GATA4_25053715_ChIP-Seq_YYC3_Human0.93315975
74SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93061579
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92265604
76ER_23166858_ChIP-Seq_MCF-7_Human0.92256057
77SALL4_22934838_ChIP-ChIP_CD34+_Human0.91646116
78* NFYA_21822215_ChIP-Seq_K562_Human0.91122819
79OCT4_18555785_Chip-Seq_ESCs_Mouse0.90925009
80SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90901388
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90011112
82CMYC_18555785_Chip-Seq_ESCs_Mouse0.89451477
83PU1_27457419_Chip-Seq_LIVER_Mouse0.89143206
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86012283
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85870452
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85233199
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83129183
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.81025957
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80906180
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80906180
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80483702
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80185419
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77896735
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77293234
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73519655
96ZNF263_19887448_ChIP-Seq_K562_Human0.71706822
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70304890
98* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69073563
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67887857
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66986884
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66372925
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65946270
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65577933
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.65318880
105EGR1_19032775_ChIP-ChIP_M12_Human0.63689924
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62579950
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.62485288
108CDX2_20551321_ChIP-Seq_CACO-2_Human0.61638130
109* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61553054
110* CEBPB_22108803_ChIP-Seq_LS180_Human0.61157618
111AR_20517297_ChIP-Seq_VCAP_Human0.59885342
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.59838598
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.58979255
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.58799831
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58437738
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56690315
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56147095
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.55883065
119SOX2_20726797_ChIP-Seq_SW620_Human0.54106489
120MYC_19915707_ChIP-ChIP_AK7_Human0.52597810
121CBP_21632823_ChIP-Seq_H3396_Human0.52136316
122LXR_22292898_ChIP-Seq_THP-1_Human0.49957251
123GATA2_19941826_ChIP-Seq_K562_Human0.48543729
124STAT1_17558387_ChIP-Seq_HELA_Human0.47429303
125* ESET_19884257_ChIP-Seq_ESCs_Mouse0.47170902
126GATA1_19941826_ChIP-Seq_K562_Human0.47119045
127BCAT_22108803_ChIP-Seq_LS180_Human0.47084445
128P53_21459846_ChIP-Seq_SAOS-2_Human0.46598964
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.46048025
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45875669
131* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45349300
132TAF2_19829295_ChIP-Seq_ESCs_Human0.45053013
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.45013191
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44992455
135TAF15_26573619_Chip-Seq_HEK293_Human0.44738813
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44701555
137GATA6_25053715_ChIP-Seq_YYC3_Human0.43747312
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43440136
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.43368073
140ERG_20517297_ChIP-Seq_VCAP_Human0.42876623
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41814996
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.41142902
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.39535329
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.39486596
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39085698
146* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.38981625
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.38877746
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.38877746
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38796158
150CDX2_22108803_ChIP-Seq_LS180_Human0.38401824
151PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.37231572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.11444985
2MP0005360_urolithiasis7.41750912
3* MP0005085_abnormal_gallbladder_physiolo5.92091265
4* MP0005365_abnormal_bile_salt5.76297645
5MP0008875_abnormal_xenobiotic_pharmacok4.89516833
6MP0003806_abnormal_nucleotide_metabolis4.19561621
7* MP0010329_abnormal_lipoprotein_level3.49574251
8* MP0003252_abnormal_bile_duct3.40959576
9MP0009840_abnormal_foam_cell3.13376870
10MP0005332_abnormal_amino_acid2.90899143
11MP0005083_abnormal_biliary_tract2.85622628
12MP0003195_calcinosis2.83700475
13MP0001666_abnormal_nutrient_absorption2.65895853
14MP0003191_abnormal_cellular_cholesterol2.47917520
15MP0004019_abnormal_vitamin_homeostasis2.23626651
16* MP0002118_abnormal_lipid_homeostasis2.19979802
17* MP0000609_abnormal_liver_physiology2.14409272
18MP0002138_abnormal_hepatobiliary_system2.00636968
19MP0005319_abnormal_enzyme/_coenzyme1.86958293
20MP0003868_abnormal_feces_composition1.74905420
21MP0001764_abnormal_homeostasis1.72229125
22MP0005584_abnormal_enzyme/coenzyme_acti1.67338009
23MP0003186_abnormal_redox_activity1.49445601
24MP0009643_abnormal_urine_homeostasis1.48015760
25MP0003011_delayed_dark_adaptation1.45391660
26MP0009697_abnormal_copulation1.43988940
27MP0009780_abnormal_chondrocyte_physiolo1.41304639
28MP0005451_abnormal_body_composition1.40993932
29MP0005670_abnormal_white_adipose1.36003690
30MP0003656_abnormal_erythrocyte_physiolo1.18319948
31MP0004130_abnormal_muscle_cell1.12957595
32* MP0000598_abnormal_liver_morphology1.10914994
33MP0005647_abnormal_sex_gland1.10438758
34MP0005636_abnormal_mineral_homeostasis1.08345780
35MP0009764_decreased_sensitivity_to1.07427896
36MP0000604_amyloidosis1.05123634
37MP0006036_abnormal_mitochondrial_physio1.03935026
38MP0003705_abnormal_hypodermis_morpholog1.03569565
39MP0009763_increased_sensitivity_to1.00785306
40MP0002876_abnormal_thyroid_physiology1.00412624
41MP0002254_reproductive_system_inflammat0.99058487
42MP0002971_abnormal_brown_adipose0.95612784
43MP0010386_abnormal_urinary_bladder0.93686440
44MP0008469_abnormal_protein_level0.93237024
45* MP0009642_abnormal_blood_homeostasis0.88894821
46MP0005084_abnormal_gallbladder_morpholo0.88078462
47MP0002078_abnormal_glucose_homeostasis0.87901826
48MP0005535_abnormal_body_temperature0.87447212
49MP0005666_abnormal_adipose_tissue0.86410562
50MP0003183_abnormal_peptide_metabolism0.85787323
51MP0005334_abnormal_fat_pad0.85785336
52MP0003690_abnormal_glial_cell0.85294660
53MP0009785_altered_susceptibility_to0.85139721
54MP0010155_abnormal_intestine_physiology0.85129719
55MP0005408_hypopigmentation0.83781560
56MP0010368_abnormal_lymphatic_system0.82669575
57MP0001661_extended_life_span0.81879541
58MP0005376_homeostasis/metabolism_phenot0.81685743
59MP0002837_dystrophic_cardiac_calcinosis0.79895107
60MP0003879_abnormal_hair_cell0.79633697
61MP0002132_abnormal_respiratory_system0.79493549
62MP0001756_abnormal_urination0.79337251
63MP0002909_abnormal_adrenal_gland0.78622908
64MP0009765_abnormal_xenobiotic_induced0.77000446
65MP0002166_altered_tumor_susceptibility0.74152433
66MP0003724_increased_susceptibility_to0.72610728
67MP0005220_abnormal_exocrine_pancreas0.71700585
68MP0005165_increased_susceptibility_to0.70148279
69MP0005266_abnormal_metabolism0.66316295
70MP0005187_abnormal_penis_morphology0.65621799
71MP0003329_amyloid_beta_deposits0.64586573
72MP0004215_abnormal_myocardial_fiber0.64439553
73MP0005448_abnormal_energy_balance0.63138695
74MP0000343_altered_response_to0.63026957
75MP0002090_abnormal_vision0.62948095
76MP0006035_abnormal_mitochondrial_morpho0.61471168
77MP0002136_abnormal_kidney_physiology0.61470704
78MP0004043_abnormal_pH_regulation0.61156747
79* MP0001845_abnormal_inflammatory_respons0.60646371
80MP0003300_gastrointestinal_ulcer0.59137065
81MP0004782_abnormal_surfactant_physiolog0.58600519
82MP0004883_abnormal_blood_vessel0.56202312
83MP0008004_abnormal_stomach_pH0.55844016
84MP0001664_abnormal_digestion0.55356944
85MP0001501_abnormal_sleep_pattern0.54735061
86MP0005058_abnormal_lysosome_morphology0.53923847
87MP0002796_impaired_skin_barrier0.52894166
88MP0002295_abnormal_pulmonary_circulatio0.52866442
89MP0006054_spinal_hemorrhage0.52527052
90MP0000639_abnormal_adrenal_gland0.52515817
91MP0008775_abnormal_heart_ventricle0.52152967
92MP0000538_abnormal_urinary_bladder0.51896803
93MP0004036_abnormal_muscle_relaxation0.51021693
94MP0003172_abnormal_lysosome_physiology0.50198039
95MP0000013_abnormal_adipose_tissue0.50174779
96MP0004185_abnormal_adipocyte_glucose0.49969123
97MP0009115_abnormal_fat_cell0.49719666
98MP0005330_cardiomyopathy0.49259095
99MP0000230_abnormal_systemic_arterial0.48432414
100MP0003638_abnormal_response/metabolism_0.47465754
101MP0001542_abnormal_bone_strength0.47276256
102MP0005379_endocrine/exocrine_gland_phen0.47027713
103MP0003953_abnormal_hormone_level0.47000976
104MP0005464_abnormal_platelet_physiology0.46857591
105MP0004381_abnormal_hair_follicle0.45495666
106MP0005023_abnormal_wound_healing0.45354384
107MP0005395_other_phenotype0.45304181
108MP0003075_altered_response_to0.45210555
109MP0002928_abnormal_bile_duct0.44372519
110MP0002970_abnormal_white_adipose0.43018079
111MP0009053_abnormal_anal_canal0.42344083
112MP0003436_decreased_susceptibility_to0.42070941
113MP0008873_increased_physiological_sensi0.41566115
114MP0008874_decreased_physiological_sensi0.41036934
115MP0009384_cardiac_valve_regurgitation0.41035080
116MP0005166_decreased_susceptibility_to0.40528328
117MP0005375_adipose_tissue_phenotype0.40524999
118MP0001881_abnormal_mammary_gland0.38701999
119MP0002168_other_aberrant_phenotype0.37774610
120MP0001765_abnormal_ion_homeostasis0.37199659
121MP0002822_catalepsy0.35444226
122MP0001853_heart_inflammation0.35348438
123MP0000249_abnormal_blood_vessel0.35087389
124MP0002060_abnormal_skin_morphology0.32561597
125MP0006082_CNS_inflammation0.32303664
126MP0008872_abnormal_physiological_respon0.31891900
127MP0004147_increased_porphyrin_level0.31541206
128MP0005164_abnormal_response_to0.31463654
129MP0000579_abnormal_nail_morphology0.30705080
130MP0003718_maternal_effect0.30565505
131MP0010234_abnormal_vibrissa_follicle0.29962700

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.89589436
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.89193233
3Deep venous thrombosis (HP:0002625)6.64808229
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.10326559
5Xanthomatosis (HP:0000991)6.04940358
6Prolonged partial thromboplastin time (HP:0003645)5.94223772
7Hypobetalipoproteinemia (HP:0003563)5.90307385
8Complement deficiency (HP:0004431)5.30971418
9Hyperlipoproteinemia (HP:0010980)5.23819300
10Hyperammonemia (HP:0001987)4.63232098
11Hypolipoproteinemia (HP:0010981)4.50650423
12Hyperglycinemia (HP:0002154)4.48149753
13Ketosis (HP:0001946)4.42334051
14Epidermoid cyst (HP:0200040)4.40941718
15Hyperglycinuria (HP:0003108)4.35934989
16Joint hemorrhage (HP:0005261)4.33668377
17Abnormality of serine family amino acid metabolism (HP:0010894)4.24850046
18Abnormality of glycine metabolism (HP:0010895)4.24850046
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19996939
20Hypoglycemic coma (HP:0001325)4.19674498
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18828410
22Abnormality of the common coagulation pathway (HP:0010990)4.15553110
23Fat malabsorption (HP:0002630)4.04215565
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00891281
25Hypoalphalipoproteinemia (HP:0003233)3.98392144
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.96566116
27Abnormality of methionine metabolism (HP:0010901)3.88072695
28Abnormality of complement system (HP:0005339)3.83954405
29Abnormality of fatty-acid metabolism (HP:0004359)3.78216199
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.59222733
31Abnormality of the intrinsic pathway (HP:0010989)3.57493782
32Conjugated hyperbilirubinemia (HP:0002908)3.53128947
33Ketoacidosis (HP:0001993)3.44943688
34Hypercholesterolemia (HP:0003124)3.42208541
35Abnormality of pyrimidine metabolism (HP:0004353)3.36298311
36Hyperbilirubinemia (HP:0002904)3.16130133
37Abnormality of serum amino acid levels (HP:0003112)3.07653651
38Steatorrhea (HP:0002570)3.07528881
39Abnormality of nucleobase metabolism (HP:0010932)3.07036915
40Delayed CNS myelination (HP:0002188)3.05732184
41Abnormality of vitamin metabolism (HP:0100508)3.02298158
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94564321
43Dicarboxylic aciduria (HP:0003215)2.94564321
44Abnormality of purine metabolism (HP:0004352)2.92406217
45Metabolic acidosis (HP:0001942)2.89236245
46Myocardial infarction (HP:0001658)2.79364628
47Lethargy (HP:0001254)2.78910784
48Skin nodule (HP:0200036)2.77151691
49Systemic lupus erythematosus (HP:0002725)2.76931455
50Hepatocellular carcinoma (HP:0001402)2.76740016
51Gout (HP:0001997)2.74235416
52Nephritis (HP:0000123)2.72886897
53Spontaneous abortion (HP:0005268)2.65259652
54Cerebral edema (HP:0002181)2.64258037
55Hyperphosphaturia (HP:0003109)2.63243360
56Generalized aminoaciduria (HP:0002909)2.57779717
57Hypoglycemic seizures (HP:0002173)2.56840982
58Purpura (HP:0000979)2.55961288
59Hypochromic microcytic anemia (HP:0004840)2.54872167
60Vascular calcification (HP:0004934)2.52926959
61Acanthocytosis (HP:0001927)2.38303855
62Abnormal gallbladder morphology (HP:0012437)2.36146895
63Recurrent gram-negative bacterial infections (HP:0005420)2.35598865
64Irritability (HP:0000737)2.33138958
65Spastic diplegia (HP:0001264)2.31935691
66Abnormality of vitamin B metabolism (HP:0004340)2.31705781
67Malnutrition (HP:0004395)2.30069957
68Pancreatitis (HP:0001733)2.30013652
69Vomiting (HP:0002013)2.29671200
70Cholelithiasis (HP:0001081)2.29125022
71Cardiovascular calcification (HP:0011915)2.24459557
72Neonatal onset (HP:0003623)2.23697736
73Sensorimotor neuropathy (HP:0007141)2.23310566
74Cholecystitis (HP:0001082)2.22606007
75Abnormal gallbladder physiology (HP:0012438)2.22606007
76Amyloidosis (HP:0011034)2.20889104
77Brushfield spots (HP:0001088)2.20713131
78Glomerulonephritis (HP:0000099)2.19583316
79Mitral stenosis (HP:0001718)2.18557223
80Late onset (HP:0003584)2.18157164
81Vacuolated lymphocytes (HP:0001922)2.14630412
82Hyperinsulinemic hypoglycemia (HP:0000825)2.14444814
83Proximal tubulopathy (HP:0000114)2.14234166
84Enlarged kidneys (HP:0000105)2.12410310
85Abnormality of proline metabolism (HP:0010907)2.10876947
86Hydroxyprolinuria (HP:0003080)2.10876947
87Abnormal urine phosphate concentration (HP:0012599)2.05374270
88Abnormal cartilage morphology (HP:0002763)2.04078664
89Renal cortical cysts (HP:0000803)2.04010131
90Hypothermia (HP:0002045)2.03635121
91Alkalosis (HP:0001948)2.02452733
92Esophageal varix (HP:0002040)2.02113886
93Glycosuria (HP:0003076)2.01462082
94Abnormality of urine glucose concentration (HP:0011016)2.01462082
95Hepatic necrosis (HP:0002605)2.01212269
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.00986772
97Increased purine levels (HP:0004368)2.00114654
98Hyperuricemia (HP:0002149)2.00114654
99Hemorrhage of the eye (HP:0011885)1.98636768
100Urinary glycosaminoglycan excretion (HP:0003541)1.98451630
101Mucopolysacchariduria (HP:0008155)1.98451630
102Opisthotonus (HP:0002179)1.97826399
103Reduced antithrombin III activity (HP:0001976)1.96034511
104Joint swelling (HP:0001386)1.95717755
105Gingival bleeding (HP:0000225)1.94671336
106Rickets (HP:0002748)1.93787864
107Cerebral palsy (HP:0100021)1.93771882
108Abnormality of the gallbladder (HP:0005264)1.93202805
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89586845
110Abnormality of polysaccharide metabolism (HP:0011012)1.89586845
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89586845
112Thrombophlebitis (HP:0004418)1.88447398
113Acute encephalopathy (HP:0006846)1.87538364
114Menorrhagia (HP:0000132)1.87528512
115Cerebral hemorrhage (HP:0001342)1.87161940
116Hypertriglyceridemia (HP:0002155)1.87085279
117Elevated hepatic transaminases (HP:0002910)1.86699236
118Abnormal enzyme/coenzyme activity (HP:0012379)1.86656714
119Nausea (HP:0002018)1.84835273
120Rhabdomyolysis (HP:0003201)1.84585809
121Abnormality of glycolipid metabolism (HP:0010969)1.84025439
122Abnormality of liposaccharide metabolism (HP:0010968)1.84025439
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.84025439
124Myoglobinuria (HP:0002913)1.83635690
125Hyperglycemia (HP:0003074)1.82155906
126Abnormality of transition element cation homeostasis (HP:0011030)1.82018662
127Symptomatic seizures (HP:0011145)1.79027206
128Arthropathy (HP:0003040)1.77854825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29552541
2MST44.63531765
3SIK14.18742189
4ERN14.12767674
5FGFR44.04359945
6MAP3K123.28631165
7INSRR3.05970698
8ACVR1B2.87531926
9TAOK32.76166893
10BMPR22.56689838
11MAPKAPK32.51924205
12ERBB42.51404792
13TESK22.45252001
14MST1R2.29791979
15TRIB32.03938097
16ERBB32.02441352
17PIK3CG1.87958268
18EIF2AK31.85339240
19EIF2AK11.79647163
20MAPK111.76321794
21MAP2K41.74265153
22FRK1.73643094
23FER1.72849105
24PKN21.69402711
25FLT31.67453631
26PHKG11.62947470
27PHKG21.62947470
28TYK21.54976234
29LMTK21.49803412
30NEK91.47456604
31LATS11.42735285
32FGFR21.41166433
33ABL21.39855127
34TESK11.35482430
35MAP4K21.34027194
36EPHB11.33486932
37TRPM71.32392308
38PTK61.30881498
39PRKAA21.24867381
40PINK11.22652263
41KDR1.21708184
42JAK21.20015312
43GRK71.18805832
44DAPK21.16543700
45ADRBK21.16165698
46NLK1.14990797
47CAMK1D1.13787219
48MAP3K31.09593433
49MET1.08679262
50TIE11.08319843
51STK161.06715888
52JAK11.05871768
53MAP2K31.04834626
54SCYL21.04097808
55TBK11.04056353
56MAP3K71.02240060
57MAPK150.99542226
58IRAK30.99337149
59PRKCE0.98785884
60MAP3K140.92543641
61STK240.92532226
62PDK40.91521411
63PDK30.91521411
64LIMK10.90276834
65MAPK40.88226825
66GRK60.87769490
67WNK40.83382648
68ERBB20.82249406
69EPHA20.81816472
70STK38L0.81495396
71EPHA30.79264001
72TEC0.78265714
73RIPK10.76657939
74PRKACG0.75965575
75PRKCZ0.75536573
76GSK3A0.75277866
77PRKG20.74483852
78CAMK2G0.72286121
79CSK0.72146793
80TGFBR20.71971462
81MYLK0.71888489
82CAMK2D0.69758458
83MAPK120.69227383
84PRKAA10.69145648
85PDPK10.67568813
86CDK60.66423020
87FGFR30.63908094
88OXSR10.61119798
89DYRK1B0.60454768
90PBK0.58668191
91PRKG10.58110414
92SGK30.56980640
93MAP3K110.56552967
94IKBKE0.56261131
95ILK0.56001907
96CSF1R0.55968559
97BCR0.55956506
98PDK20.55277228
99AKT30.55002083
100PIM20.54441441
101ZAP700.54261773
102PIK3CA0.53699576
103PRKCQ0.53661735
104MAP2K10.53443740
105BRSK20.51791096
106SGK4940.51706941
107SGK2230.51706941
108IGF1R0.51366715
109STK30.51111404
110CAMK1G0.51001236
111MAP2K60.50961147
112MAP3K100.50507621
113GRK10.50459157
114PRKACA0.50201473
115IRAK10.49890332
116PKN10.47887366
117CSNK1G30.45896777
118IRAK20.45574598
119BMPR1B0.44955131
120CSNK1G10.44606941
121PTK20.44409031
122ROCK10.44171476
123DAPK10.43650535
124DAPK30.43107090
125MAPK70.42431353
126WNK30.41487904
127PDK10.40291310
128SGK20.38638530
129MAP3K20.37665763
130MAP2K20.37411810
131STK390.37392279
132ADRBK10.35733133
133GRK50.35480247
134PAK30.35341899
135NEK10.34993358
136RET0.34968663
137ROCK20.33750172
138CSNK1A10.32724874
139MUSK0.31066159
140CAMKK20.30913433
141ITK0.29810780
142PRKD10.29063432
143MAP3K10.27598675
144EGFR0.27468075
145MAP3K130.26359009
146ABL10.24762704
147PRKCA0.24512085
148OBSCN0.24096181
149MAP3K50.23558233

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.13940135
2Nitrogen metabolism_Homo sapiens_hsa009103.34332365
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19212977
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06205721
5Arginine biosynthesis_Homo sapiens_hsa002202.82934995
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71534480
7Fatty acid degradation_Homo sapiens_hsa000712.70326183
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69865385
9Tryptophan metabolism_Homo sapiens_hsa003802.69128217
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67751958
11Complement and coagulation cascades_Homo sapiens_hsa046102.52954530
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45736221
13Butanoate metabolism_Homo sapiens_hsa006502.29363672
14Propanoate metabolism_Homo sapiens_hsa006402.29188897
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21271416
16* Peroxisome_Homo sapiens_hsa041462.16399208
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10091504
18Fatty acid metabolism_Homo sapiens_hsa012122.05221399
19* PPAR signaling pathway_Homo sapiens_hsa033201.98069069
20Histidine metabolism_Homo sapiens_hsa003401.87819310
21Chemical carcinogenesis_Homo sapiens_hsa052041.85966338
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85867487
23beta-Alanine metabolism_Homo sapiens_hsa004101.79782535
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.79370619
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79295386
26Caffeine metabolism_Homo sapiens_hsa002321.73788426
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70759246
28Retinol metabolism_Homo sapiens_hsa008301.63257868
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62805402
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.61634184
31Staphylococcus aureus infection_Homo sapiens_hsa051501.61181833
32Fatty acid elongation_Homo sapiens_hsa000621.60204013
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56788916
34Pyruvate metabolism_Homo sapiens_hsa006201.55095450
35Phenylalanine metabolism_Homo sapiens_hsa003601.54189146
36Sulfur metabolism_Homo sapiens_hsa009201.49621905
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45117463
38Selenocompound metabolism_Homo sapiens_hsa004501.43550684
39Tyrosine metabolism_Homo sapiens_hsa003501.42259252
40Bile secretion_Homo sapiens_hsa049761.42224495
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30817741
42Carbon metabolism_Homo sapiens_hsa012001.26135655
43Fat digestion and absorption_Homo sapiens_hsa049751.25655672
44Folate biosynthesis_Homo sapiens_hsa007901.21840804
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.19834226
46Steroid biosynthesis_Homo sapiens_hsa001001.18833748
47ABC transporters_Homo sapiens_hsa020101.17807818
48Biosynthesis of amino acids_Homo sapiens_hsa012301.15064079
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08976775
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.02952837
51Vitamin B6 metabolism_Homo sapiens_hsa007500.96678320
52Arginine and proline metabolism_Homo sapiens_hsa003300.96559499
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.95882513
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94332615
55Vitamin digestion and absorption_Homo sapiens_hsa049770.92544745
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91274928
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90903526
58Sulfur relay system_Homo sapiens_hsa041220.90629365
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85633828
60Glycerolipid metabolism_Homo sapiens_hsa005610.82590566
61Glutathione metabolism_Homo sapiens_hsa004800.77561447
62Lysine degradation_Homo sapiens_hsa003100.75997328
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74202695
64Fatty acid biosynthesis_Homo sapiens_hsa000610.72775375
65Pentose phosphate pathway_Homo sapiens_hsa000300.61328882
66Protein export_Homo sapiens_hsa030600.52015077
67Other glycan degradation_Homo sapiens_hsa005110.50580914
68* Metabolic pathways_Homo sapiens_hsa011000.49541364
69One carbon pool by folate_Homo sapiens_hsa006700.49006454
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45637377
71Sphingolipid metabolism_Homo sapiens_hsa006000.37480093
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35490807
73Pertussis_Homo sapiens_hsa051330.34606395
74Prion diseases_Homo sapiens_hsa050200.34261564
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31723668
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.30615473
77Fructose and mannose metabolism_Homo sapiens_hsa000510.29612063
78Galactose metabolism_Homo sapiens_hsa000520.29348451
79Insulin resistance_Homo sapiens_hsa049310.26740964
80Asthma_Homo sapiens_hsa053100.26666611
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25394672
82Collecting duct acid secretion_Homo sapiens_hsa049660.25042382
83Linoleic acid metabolism_Homo sapiens_hsa005910.23409126
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.19449220
85Alzheimers disease_Homo sapiens_hsa050100.17794754
86Type I diabetes mellitus_Homo sapiens_hsa049400.17271624
87Circadian rhythm_Homo sapiens_hsa047100.15614779
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15142179
89Pancreatic secretion_Homo sapiens_hsa049720.15003450
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13015643
91Proteasome_Homo sapiens_hsa030500.11490454
92Glucagon signaling pathway_Homo sapiens_hsa049220.09637560
93AMPK signaling pathway_Homo sapiens_hsa041520.08257233
94Rheumatoid arthritis_Homo sapiens_hsa053230.07215597
95Serotonergic synapse_Homo sapiens_hsa047260.05161700
96Parkinsons disease_Homo sapiens_hsa05012-0.2222921
97Amoebiasis_Homo sapiens_hsa05146-0.2173430
98African trypanosomiasis_Homo sapiens_hsa05143-0.1906875
99Protein digestion and absorption_Homo sapiens_hsa04974-0.1868070
100Mineral absorption_Homo sapiens_hsa04978-0.1866520
101Ether lipid metabolism_Homo sapiens_hsa00565-0.1743062
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1724484
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1687609
104Lysosome_Homo sapiens_hsa04142-0.1657132
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1607244
106Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1537835
107Hepatitis C_Homo sapiens_hsa05160-0.1534237
108Oxidative phosphorylation_Homo sapiens_hsa00190-0.1516087
109Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1432472
110Regulation of autophagy_Homo sapiens_hsa04140-0.0803019
111Renin-angiotensin system_Homo sapiens_hsa04614-0.0795975
112Insulin signaling pathway_Homo sapiens_hsa04910-0.0776906
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0735996
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0619162
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0432466

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