SCNN1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.64570901
2positive regulation of protein kinase C signaling (GO:0090037)4.54079252
3regulation of ARF GTPase activity (GO:0032312)4.53678747
4cell-cell junction maintenance (GO:0045217)4.36627961
5positive regulation of synapse maturation (GO:0090129)4.32938220
6neuronal ion channel clustering (GO:0045161)4.20409509
7synaptic vesicle exocytosis (GO:0016079)4.13367953
8histone H4 deacetylation (GO:0070933)4.02351069
9regulation of hydrogen peroxide metabolic process (GO:0010310)3.99291008
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86026556
11semaphorin-plexin signaling pathway (GO:0071526)3.83894438
12glutamate secretion (GO:0014047)3.81636207
13positive regulation of histone deacetylation (GO:0031065)3.66954792
14regulation of synapse maturation (GO:0090128)3.65181694
15histone H3 deacetylation (GO:0070932)3.62381477
16acrosome reaction (GO:0007340)3.59218049
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53702442
18regulation of synapse structural plasticity (GO:0051823)3.51605051
19axon ensheathment in central nervous system (GO:0032291)3.48352303
20central nervous system myelination (GO:0022010)3.48352303
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.44342030
22mitochondrion transport along microtubule (GO:0047497)3.44342030
23histone H3-K9 demethylation (GO:0033169)3.40171652
24regulation of synaptic vesicle exocytosis (GO:2000300)3.39466400
25locomotory exploration behavior (GO:0035641)3.37957993
26cell migration in hindbrain (GO:0021535)3.36841635
27urinary tract smooth muscle contraction (GO:0014848)3.34455942
28establishment of mitochondrion localization (GO:0051654)3.30155687
29cell junction maintenance (GO:0034331)3.24296720
30postsynaptic membrane organization (GO:0001941)3.21993473
31mannose metabolic process (GO:0006013)3.16119731
32regulation of ARF protein signal transduction (GO:0032012)3.14881698
33negative regulation of erythrocyte differentiation (GO:0045647)3.14275629
34cerebellar granule cell differentiation (GO:0021707)3.10601889
35negative regulation of inclusion body assembly (GO:0090084)3.10559019
36synaptic vesicle maturation (GO:0016188)3.07529784
37peptidyl-tyrosine autophosphorylation (GO:0038083)3.04473003
38negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.01261197
39cerebral cortex neuron differentiation (GO:0021895)2.99367122
40dendritic spine morphogenesis (GO:0060997)2.97306272
41sperm capacitation (GO:0048240)2.97053687
42regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93515654
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93087437
44negative regulation of granulocyte differentiation (GO:0030853)2.91907512
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91198828
46calcium ion-dependent exocytosis (GO:0017156)2.90758010
47epithelial cell fate commitment (GO:0072148)2.85047882
48regulation of glutamate receptor signaling pathway (GO:1900449)2.82744489
49regulation of synaptic vesicle transport (GO:1902803)2.73549489
50response to acidic pH (GO:0010447)2.73326239
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70004366
52neuron remodeling (GO:0016322)2.69957180
53positive regulation of CREB transcription factor activity (GO:0032793)2.69334686
54endothelial cell chemotaxis (GO:0035767)2.68683614
55regulation of glycogen (starch) synthase activity (GO:2000465)2.67039780
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66553167
57neuromuscular process controlling balance (GO:0050885)2.64878613
58sodium ion export (GO:0071436)2.62924426
59cranial nerve morphogenesis (GO:0021602)2.62347301
60cAMP biosynthetic process (GO:0006171)2.62282149
61regulation of monocyte differentiation (GO:0045655)2.61742492
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.61710989
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61650609
64neurotransmitter-gated ion channel clustering (GO:0072578)2.59982918
65exploration behavior (GO:0035640)2.59826609
66histone H3-K4 trimethylation (GO:0080182)2.58356773
67negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57151410
68lung epithelium development (GO:0060428)2.55323434
69UV protection (GO:0009650)2.54786046
70regulation of Rab GTPase activity (GO:0032313)2.54185120
71positive regulation of Rab GTPase activity (GO:0032851)2.54185120
72protein localization to synapse (GO:0035418)2.53562590
73dendritic spine organization (GO:0097061)2.53022994
74protein retention in ER lumen (GO:0006621)2.52787307
75camera-type eye morphogenesis (GO:0048593)2.50874404
76negative regulation of cell size (GO:0045792)2.50689208
77activation of JUN kinase activity (GO:0007257)2.50355986
78atrioventricular valve morphogenesis (GO:0003181)2.49577905
79neurotransmitter secretion (GO:0007269)2.49156844
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47864807
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47452666
82positive regulation of Rap GTPase activity (GO:0032854)2.46346378
83neuron projection extension (GO:1990138)2.46170005
84layer formation in cerebral cortex (GO:0021819)2.43806929
85chondroitin sulfate catabolic process (GO:0030207)2.43654301
86activation of MAPKKK activity (GO:0000185)2.43236841
87cytoskeletal anchoring at plasma membrane (GO:0007016)2.43119001
88cellular response to pH (GO:0071467)2.42644636
89regulation of neuronal synaptic plasticity (GO:0048168)2.41734208
90synaptic vesicle endocytosis (GO:0048488)2.41732641
91regulation of somitogenesis (GO:0014807)2.41604249
92regulation of ruffle assembly (GO:1900027)2.38944483
93ionotropic glutamate receptor signaling pathway (GO:0035235)2.38937469
94sperm motility (GO:0030317)2.38885751
95microtubule severing (GO:0051013)2.38849486
96positive regulation of membrane potential (GO:0045838)2.37679365
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.37084709
98regulation of protein kinase C signaling (GO:0090036)2.37005088
99adenosine receptor signaling pathway (GO:0001973)2.36267866
100regulation of T-helper 2 cell differentiation (GO:0045628)2.36140193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.57877192
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36913244
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.29691138
4LXR_22292898_ChIP-Seq_THP-1_Human3.21071143
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60285936
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59724635
7DROSHA_22980978_ChIP-Seq_HELA_Human2.45022054
8* P68_20966046_ChIP-Seq_HELA_Human2.41243190
9* CTCF_27219007_Chip-Seq_Bcells_Human2.38625178
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.29313850
11* KDM2B_26808549_Chip-Seq_K562_Human2.28011545
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21415975
13KDM2B_26808549_Chip-Seq_DND41_Human2.20604907
14VDR_21846776_ChIP-Seq_THP-1_Human2.17488528
15* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.15445773
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.12919759
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11469968
18SMC4_20622854_ChIP-Seq_HELA_Human2.07465128
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07145741
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00048131
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95061745
22EZH2_22144423_ChIP-Seq_EOC_Human1.94096002
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.93852838
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.93109133
25RACK7_27058665_Chip-Seq_MCF-7_Human1.91761516
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.88338686
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86722873
28TCF7_22412390_ChIP-Seq_EML_Mouse1.86574806
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.84101320
30* SA1_27219007_Chip-Seq_ERYTHROID_Human1.81204437
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.77703487
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77289815
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.77222782
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72752445
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.70139197
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69145975
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69131191
38* CREB1_26743006_Chip-Seq_LNCaP_Human1.66744570
39BCL6_27268052_Chip-Seq_Bcells_Human1.66275359
40* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65459519
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.65423430
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.62759535
43* BCOR_27268052_Chip-Seq_Bcells_Human1.58033538
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57676603
45* E2F1_20622854_ChIP-Seq_HELA_Human1.57056350
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56497667
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54754869
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54167663
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.53868961
50PHF8_20622854_ChIP-Seq_HELA_Human1.50903063
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.50200643
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49681565
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49681565
54* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47830954
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.47160070
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44949077
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43966030
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41457526
59TP63_22573176_ChIP-Seq_HFKS_Human1.41400614
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40957120
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40795444
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40197308
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36788385
64* SA1_27219007_Chip-Seq_Bcells_Human1.34580007
65OCT4_19829295_ChIP-Seq_ESCs_Human1.34493282
66MYC_22102868_ChIP-Seq_BL_Human1.33435182
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.28934626
68* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28340518
69MAF_26560356_Chip-Seq_TH2_Human1.27195385
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24946937
71* CTCF_20526341_ChIP-Seq_ESCs_Human1.23883116
72TP53_22127205_ChIP-Seq_IMR90_Human1.22802818
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.20171756
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19392683
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.18546791
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14753052
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.13843642
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13465351
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.12632097
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.12489382
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11565427
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11266635
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.11225746
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10593377
85RARB_24833708_ChIP-Seq_LIVER_Mouse1.10439886
86REST_21632747_ChIP-Seq_MESCs_Mouse1.10281385
87CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09100724
88* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08742588
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07649446
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06979709
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.06962505
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06777892
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06165585
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.05488310
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05114297
96KLF4_19829295_ChIP-Seq_ESCs_Human1.05037695
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03531552
98CTCF_21964334_Chip-Seq_Bcells_Human1.03449293
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01563149
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00116039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17750594
2MP0005409_darkened_coat_color3.76176411
3MP0005423_abnormal_somatic_nervous3.73528883
4MP0005377_hearing/vestibular/ear_phenot3.48700667
5MP0003878_abnormal_ear_physiology3.48700667
6MP0002249_abnormal_larynx_morphology3.07433200
7MP0003172_abnormal_lysosome_physiology2.94314032
8MP0003136_yellow_coat_color2.82394803
9MP0003879_abnormal_hair_cell2.79200029
10MP0001188_hyperpigmentation2.61692518
11MP0003635_abnormal_synaptic_transmissio2.28706108
12MP0001348_abnormal_lacrimal_gland2.12439579
13MP0000678_abnormal_parathyroid_gland2.07896213
14MP0002063_abnormal_learning/memory/cond2.04422914
15MP0001968_abnormal_touch/_nociception2.03658844
16MP0001502_abnormal_circadian_rhythm2.00851651
17MP0009379_abnormal_foot_pigmentation1.97819534
18MP0002822_catalepsy1.96042689
19MP0003880_abnormal_central_pattern1.93588350
20MP0005058_abnormal_lysosome_morphology1.92959495
21MP0003705_abnormal_hypodermis_morpholog1.89678939
22MP0005410_abnormal_fertilization1.84991928
23MP0005670_abnormal_white_adipose1.80816195
24MP0001486_abnormal_startle_reflex1.73436067
25MP0004510_myositis1.71710157
26MP0003329_amyloid_beta_deposits1.70632569
27MP0002064_seizures1.67232471
28MP0004270_analgesia1.67022674
29MP0004381_abnormal_hair_follicle1.65198859
30MP0002735_abnormal_chemical_nociception1.61551645
31MP0002572_abnormal_emotion/affect_behav1.59878876
32MP0008569_lethality_at_weaning1.56635059
33MP0001849_ear_inflammation1.55335137
34MP0009384_cardiac_valve_regurgitation1.52690035
35MP0001970_abnormal_pain_threshold1.48425457
36MP0000003_abnormal_adipose_tissue1.45668563
37MP0004885_abnormal_endolymph1.42299035
38MP0003453_abnormal_keratinocyte_physiol1.39165167
39MP0009745_abnormal_behavioral_response1.39126406
40MP0000778_abnormal_nervous_system1.39048260
41MP0000566_synostosis1.35933948
42MP0009780_abnormal_chondrocyte_physiolo1.29334297
43MP0000751_myopathy1.29183416
44MP0002234_abnormal_pharynx_morphology1.28204368
45MP0002653_abnormal_ependyma_morphology1.27666224
46MP0002272_abnormal_nervous_system1.27050032
47MP0000955_abnormal_spinal_cord1.24913636
48MP0002733_abnormal_thermal_nociception1.20153184
49MP0005375_adipose_tissue_phenotype1.16368134
50MP0005174_abnormal_tail_pigmentation1.16301040
51MP0006276_abnormal_autonomic_nervous1.16246585
52MP0000026_abnormal_inner_ear1.14540207
53MP0001986_abnormal_taste_sensitivity1.12546068
54MP0001485_abnormal_pinna_reflex1.12466597
55MP0002734_abnormal_mechanical_nocicepti1.12389903
56MP0005666_abnormal_adipose_tissue1.10772356
57MP0002796_impaired_skin_barrier1.10418784
58MP0004043_abnormal_pH_regulation1.10118914
59MP0002933_joint_inflammation1.09687029
60MP0002557_abnormal_social/conspecific_i1.08965787
61MP0003690_abnormal_glial_cell1.08156252
62MP0003183_abnormal_peptide_metabolism1.07385310
63MP0009278_abnormal_bone_marrow1.06594131
64MP0002882_abnormal_neuron_morphology1.05446850
65MP0000015_abnormal_ear_pigmentation1.03793108
66MP0003634_abnormal_glial_cell1.01316763
67MP0003279_aneurysm1.01237013
68MP0001963_abnormal_hearing_physiology0.99645825
69MP0004742_abnormal_vestibular_system0.96420782
70MP0001440_abnormal_grooming_behavior0.96220689
71MP0000681_abnormal_thyroid_gland0.93500814
72MP0002932_abnormal_joint_morphology0.90963059
73MP0006292_abnormal_olfactory_placode0.88420838
74MP0004130_abnormal_muscle_cell0.86879609
75MP0000579_abnormal_nail_morphology0.85310808
76MP0001958_emphysema0.83998109
77MP0003137_abnormal_impulse_conducting0.83894069
78MP0005535_abnormal_body_temperature0.83882733
79MP0002067_abnormal_sensory_capabilities0.83155068
80MP0003122_maternal_imprinting0.82225952
81MP0003698_abnormal_male_reproductive0.81802080
82MP0008874_decreased_physiological_sensi0.81293474
83MP0005501_abnormal_skin_physiology0.81035096
84MP0004858_abnormal_nervous_system0.79243935
85MP0004811_abnormal_neuron_physiology0.78779557
86MP0001299_abnormal_eye_distance/0.78227830
87MP0005076_abnormal_cell_differentiation0.78145811
88MP0002066_abnormal_motor_capabilities/c0.77596097
89MP0002152_abnormal_brain_morphology0.77462245
90MP0003787_abnormal_imprinting0.75033907
91MP0002184_abnormal_innervation0.72482697
92MP0004185_abnormal_adipocyte_glucose0.72387731
93MP0009840_abnormal_foam_cell0.71163537
94MP0003942_abnormal_urinary_system0.69849577
95MP0000013_abnormal_adipose_tissue0.68312252
96MP0000920_abnormal_myelination0.66899466
97MP0003436_decreased_susceptibility_to0.65850545
98MP0002752_abnormal_somatic_nervous0.65261548
99MP0005503_abnormal_tendon_morphology0.65190231
100MP0000467_abnormal_esophagus_morphology0.64539426

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.78425402
2Thin bony cortex (HP:0002753)4.30633103
3Cervical subluxation (HP:0003308)3.77086674
4Annular pancreas (HP:0001734)3.61267893
5Broad face (HP:0000283)3.45122213
6Supranuclear gaze palsy (HP:0000605)3.26596686
7J-shaped sella turcica (HP:0002680)3.22709741
8Turricephaly (HP:0000262)3.16501462
9Myokymia (HP:0002411)3.11993693
10Stridor (HP:0010307)3.03787266
11Nuclear cataract (HP:0100018)2.95201206
12Sleep apnea (HP:0010535)2.93815421
13Neurofibrillary tangles (HP:0002185)2.89111769
14Cerebral aneurysm (HP:0004944)2.88047771
15Lymphangioma (HP:0100764)2.83532814
16Papilledema (HP:0001085)2.78084121
17Spinal canal stenosis (HP:0003416)2.73698066
18Abnormality of the aortic arch (HP:0012303)2.73520084
19Abnormality of nail color (HP:0100643)2.69561981
20Testicular atrophy (HP:0000029)2.66118917
21Joint stiffness (HP:0001387)2.64034980
22Urinary glycosaminoglycan excretion (HP:0003541)2.63022201
23Mucopolysacchariduria (HP:0008155)2.63022201
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57233774
25Abnormality of polysaccharide metabolism (HP:0011012)2.57233774
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57233774
27Hyperacusis (HP:0010780)2.54372122
28Broad metatarsal (HP:0001783)2.53571579
29Atelectasis (HP:0100750)2.50203727
30Cerebral inclusion bodies (HP:0100314)2.39743748
31Distal upper limb amyotrophy (HP:0007149)2.32816966
32Upper limb amyotrophy (HP:0009129)2.32816966
33Biconcave vertebral bodies (HP:0004586)2.31326950
34Hemorrhage of the eye (HP:0011885)2.29864445
35Shallow orbits (HP:0000586)2.28764513
36Vitreoretinal degeneration (HP:0000655)2.27088982
37Ulnar bowing (HP:0003031)2.24327750
38Dysostosis multiplex (HP:0000943)2.20596983
39Mesangial abnormality (HP:0001966)2.19870951
40Renal dysplasia (HP:0000110)2.15254828
41Metaphyseal cupping (HP:0003021)2.14288140
42Aortic regurgitation (HP:0001659)2.12004202
43Delayed CNS myelination (HP:0002188)2.10942111
44Hypoplastic ischia (HP:0003175)2.10610865
45Pointed chin (HP:0000307)2.08725826
46Rib fusion (HP:0000902)2.07206009
47Akinesia (HP:0002304)2.07112141
48Ankle clonus (HP:0011448)2.06295964
49Easy fatigability (HP:0003388)2.06002586
50Abnormality of binocular vision (HP:0011514)2.05650175
51Diplopia (HP:0000651)2.05650175
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05219393
53Flattened epiphyses (HP:0003071)2.02128032
54Mitral regurgitation (HP:0001653)1.99370761
55Asymmetric septal hypertrophy (HP:0001670)1.99279651
56Bronchomalacia (HP:0002780)1.99076600
57Hyperthyroidism (HP:0000836)1.99018720
58Neoplasm of the heart (HP:0100544)1.96667786
59Long palpebral fissure (HP:0000637)1.94659016
60Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92897491
61Thin ribs (HP:0000883)1.92213210
62Deformed sella turcica (HP:0002681)1.89115150
63Postural instability (HP:0002172)1.86285595
64Neuronal loss in central nervous system (HP:0002529)1.85069531
65Flared iliac wings (HP:0002869)1.83951937
66Increased IgE level (HP:0003212)1.83208070
67Ocular albinism (HP:0001107)1.82830216
68Focal seizures (HP:0007359)1.82085476
69Truncus arteriosus (HP:0001660)1.80812284
70Bowel incontinence (HP:0002607)1.79810005
71Fetal akinesia sequence (HP:0001989)1.78542428
72Atonic seizures (HP:0010819)1.77038760
73Abnormal atrioventricular conduction (HP:0005150)1.75039865
74Bell-shaped thorax (HP:0001591)1.73871250
75Heart block (HP:0012722)1.72829271
76Abnormality of the thoracic spine (HP:0100711)1.72265108
77Abnormality of the femoral head (HP:0003368)1.72176093
78Hand muscle atrophy (HP:0009130)1.72041813
79Genetic anticipation (HP:0003743)1.71750987
80Severe visual impairment (HP:0001141)1.71427543
81Deep palmar crease (HP:0006191)1.71342665
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71221373
83Axonal loss (HP:0003447)1.71024463
84Supernumerary ribs (HP:0005815)1.70918105
85Joint hemorrhage (HP:0005261)1.69248785
86Myopathic facies (HP:0002058)1.68716504
87Precocious puberty (HP:0000826)1.67741347
88Thickened helices (HP:0000391)1.67679461
89Iris hypopigmentation (HP:0007730)1.67677777
90Emphysema (HP:0002097)1.66119931
91Thoracic kyphosis (HP:0002942)1.65675738
92Laryngomalacia (HP:0001601)1.65632445
93Prolonged QT interval (HP:0001657)1.64828451
94Stereotypic behavior (HP:0000733)1.64157357
95Abnormality of the ischium (HP:0003174)1.64114284
96Vertebral clefting (HP:0008428)1.64045453
97Impulsivity (HP:0100710)1.63844444
98Deep venous thrombosis (HP:0002625)1.63786505
99Hyperkalemia (HP:0002153)1.63602537
100Enlarged epiphyses (HP:0010580)1.63105047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.55475247
2TRIB33.20358336
3MAPK153.03226468
4SIK12.94095433
5SIK22.68120182
6RIPK12.37968419
7TNK22.24340412
8MARK22.21609865
9MARK12.20606034
10TYRO31.94539329
11NTRK31.89773942
12PRKD31.86036643
13MAP3K61.74466857
14ERN11.70620256
15DDR21.65687485
16TESK11.64542746
17NTRK21.56893727
18MAP3K111.55755362
19EPHA21.49169956
20CAMKK11.48396905
21ICK1.47680828
22PRPF4B1.46340676
23MAP3K71.43289341
24EEF2K1.42184248
25RPS6KA21.40994255
26DYRK1B1.39559441
27EPHA41.39544913
28DAPK21.33915827
29MAP2K61.29189548
30PRKD21.26786357
31NTRK11.23406980
32UHMK11.23341158
33MAP3K131.23303714
34PRKCH1.21882922
35CDC42BPA1.15565222
36PAK61.13212967
37STK381.09324069
38FGFR41.05085864
39BRAF1.04475492
40ARAF1.03982191
41CAMK1G1.03874270
42BLK1.01867964
43MAPK121.00529687
44EPHB10.99818150
45PDPK10.97314565
46RPS6KC10.96581966
47RPS6KL10.96581966
48BMX0.96315488
49CAMK10.95240422
50WNK40.94093512
51PDGFRA0.93821041
52KSR20.91788733
53RPS6KA60.87366251
54SMG10.86389474
55MTOR0.85819039
56PNCK0.83725908
57MAP2K30.83317115
58CAMK1D0.82260874
59MINK10.78977630
60ERBB20.78127563
61INSRR0.77459762
62MST1R0.76473448
63SGK2230.75960099
64SGK4940.75960099
65PKN20.73813989
66TAOK10.71545921
67PKN10.71412459
68PDK10.66527877
69CDK50.62306781
70MAPK80.61589736
71RIPK40.61090713
72GRK60.58979533
73CDK120.58894992
74MAP3K10.58873126
75PTK60.56828252
76HIPK20.56046453
77STK110.55266950
78WNK10.53789307
79MUSK0.53753529
80PTK20.52620339
81MAPK40.51396481
82MAP4K10.49789058
83MAPK70.49780632
84ZAP700.48884945
85NME10.48671638
86PRKAA10.48649021
87MAPK100.47539865
88SGK30.46364862
89CAMK40.46277599
90CDK11A0.44198116
91CDK90.42655221
92MAP2K40.41342714
93ROCK10.40461848
94KDR0.39879089
95PDGFRB0.38598370
96RET0.37154316
97MAP2K20.37130941
98IRAK20.36174201
99TBK10.36061336
100PRKCZ0.35998575

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.54570555
2Other glycan degradation_Homo sapiens_hsa005112.32852283
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.27834146
4VEGF signaling pathway_Homo sapiens_hsa043701.94681171
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84425235
6Synaptic vesicle cycle_Homo sapiens_hsa047211.81831470
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76306225
8Long-term potentiation_Homo sapiens_hsa047201.71322698
9GnRH signaling pathway_Homo sapiens_hsa049121.65130496
10Cocaine addiction_Homo sapiens_hsa050301.64806409
11Insulin secretion_Homo sapiens_hsa049111.60985487
12Circadian entrainment_Homo sapiens_hsa047131.59559810
13Phospholipase D signaling pathway_Homo sapiens_hsa040721.57720773
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54014356
15Glutamatergic synapse_Homo sapiens_hsa047241.53209771
16Nicotine addiction_Homo sapiens_hsa050331.50648523
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42841788
18Cholinergic synapse_Homo sapiens_hsa047251.38738910
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37382724
20Estrogen signaling pathway_Homo sapiens_hsa049151.36448495
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33460444
22Morphine addiction_Homo sapiens_hsa050321.31980868
23Prion diseases_Homo sapiens_hsa050201.31159077
24Gastric acid secretion_Homo sapiens_hsa049711.30365875
25Axon guidance_Homo sapiens_hsa043601.29838570
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.29621714
27Melanogenesis_Homo sapiens_hsa049161.27256227
28Amphetamine addiction_Homo sapiens_hsa050311.26445085
29Choline metabolism in cancer_Homo sapiens_hsa052311.21228161
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18357931
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17937560
32Oxytocin signaling pathway_Homo sapiens_hsa049211.15656578
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.15468625
34GABAergic synapse_Homo sapiens_hsa047271.13722657
35MAPK signaling pathway_Homo sapiens_hsa040101.11723863
36ErbB signaling pathway_Homo sapiens_hsa040121.07887445
37cAMP signaling pathway_Homo sapiens_hsa040241.07330359
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07069301
39Bile secretion_Homo sapiens_hsa049761.04757672
40Dorso-ventral axis formation_Homo sapiens_hsa043201.04605392
41Dopaminergic synapse_Homo sapiens_hsa047281.04204316
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.03678842
43Calcium signaling pathway_Homo sapiens_hsa040201.03670761
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02590171
45Glioma_Homo sapiens_hsa052141.01835675
46Acute myeloid leukemia_Homo sapiens_hsa052210.97025966
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96733898
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95169502
49Inositol phosphate metabolism_Homo sapiens_hsa005620.94787849
50Taste transduction_Homo sapiens_hsa047420.94210462
51ABC transporters_Homo sapiens_hsa020100.93649608
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92938050
53Salivary secretion_Homo sapiens_hsa049700.92844023
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89835696
55Long-term depression_Homo sapiens_hsa047300.87974861
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.87219700
57Endocytosis_Homo sapiens_hsa041440.85864154
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85850695
59Rap1 signaling pathway_Homo sapiens_hsa040150.85702652
60Sulfur relay system_Homo sapiens_hsa041220.85445077
61mTOR signaling pathway_Homo sapiens_hsa041500.84912392
62Fatty acid biosynthesis_Homo sapiens_hsa000610.84809200
63Insulin signaling pathway_Homo sapiens_hsa049100.84434013
64Gap junction_Homo sapiens_hsa045400.80529658
65Bladder cancer_Homo sapiens_hsa052190.79558520
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79493489
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74103375
68Chronic myeloid leukemia_Homo sapiens_hsa052200.70766177
69Lysine degradation_Homo sapiens_hsa003100.69809840
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68734309
71Ras signaling pathway_Homo sapiens_hsa040140.68627869
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67767330
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66576732
74Non-small cell lung cancer_Homo sapiens_hsa052230.66216988
75Renin secretion_Homo sapiens_hsa049240.65982405
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65200478
77Glucagon signaling pathway_Homo sapiens_hsa049220.65126809
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64397446
79Serotonergic synapse_Homo sapiens_hsa047260.64245219
80Ovarian steroidogenesis_Homo sapiens_hsa049130.63794397
81Prolactin signaling pathway_Homo sapiens_hsa049170.63788720
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63632203
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60243362
84AMPK signaling pathway_Homo sapiens_hsa041520.59788469
85Type II diabetes mellitus_Homo sapiens_hsa049300.58553775
86PPAR signaling pathway_Homo sapiens_hsa033200.57814363
87Phenylalanine metabolism_Homo sapiens_hsa003600.56842302
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.55294323
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55018544
90B cell receptor signaling pathway_Homo sapiens_hsa046620.53032771
91Dilated cardiomyopathy_Homo sapiens_hsa054140.50778125
92Thyroid hormone synthesis_Homo sapiens_hsa049180.48197265
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46546602
94Fructose and mannose metabolism_Homo sapiens_hsa000510.46441564
95Focal adhesion_Homo sapiens_hsa045100.45431208
96Insulin resistance_Homo sapiens_hsa049310.44723635
97Renal cell carcinoma_Homo sapiens_hsa052110.44715575
98Endometrial cancer_Homo sapiens_hsa052130.43557929
99Linoleic acid metabolism_Homo sapiens_hsa005910.42935289
100Hedgehog signaling pathway_Homo sapiens_hsa043400.42792921

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