SCMH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)3.64454327
2actin-myosin filament sliding (GO:0033275)3.56197989
3muscle filament sliding (GO:0030049)3.56197989
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.52913384
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.47469059
6nuclear pore complex assembly (GO:0051292)3.37975719
7negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29266203
8neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16998632
9peptidyl-lysine dimethylation (GO:0018027)3.11426917
10actin-mediated cell contraction (GO:0070252)3.09230821
11central nervous system projection neuron axonogenesis (GO:0021952)3.05786914
12microtubule nucleation (GO:0007020)3.04237369
13response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.03818413
14establishment of nucleus localization (GO:0040023)3.03675649
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01005083
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00855417
17chromosome condensation (GO:0030261)2.97106992
18myofibril assembly (GO:0030239)2.97007863
19vocalization behavior (GO:0071625)2.95496776
20striatum development (GO:0021756)2.94385552
21regulation of NFAT protein import into nucleus (GO:0051532)2.93242177
22negative regulation of cell size (GO:0045792)2.92547172
23urinary tract smooth muscle contraction (GO:0014848)2.86670212
24cranial nerve morphogenesis (GO:0021602)2.85445647
25DNA packaging (GO:0006323)2.85380191
26regulation of membrane repolarization (GO:0060306)2.84138407
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82132515
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82071255
29nucleus localization (GO:0051647)2.81479334
30synaptic vesicle docking involved in exocytosis (GO:0016081)2.81102338
31negative regulation of dendrite development (GO:2000171)2.79792973
32carnitine shuttle (GO:0006853)2.79456094
33cardiac muscle hypertrophy (GO:0003300)2.78979263
34cerebellar Purkinje cell differentiation (GO:0021702)2.78892005
35insulin-like growth factor receptor signaling pathway (GO:0048009)2.77982901
36regulation of synapse structural plasticity (GO:0051823)2.77759190
37histone H3-K9 demethylation (GO:0033169)2.76139364
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74318535
39biotin metabolic process (GO:0006768)2.73398815
40definitive hemopoiesis (GO:0060216)2.73132591
41heparin biosynthetic process (GO:0030210)2.72894253
42heparin metabolic process (GO:0030202)2.72894253
43positive regulation of synapse maturation (GO:0090129)2.71416040
44neurotransmitter-gated ion channel clustering (GO:0072578)2.71075980
45axonal fasciculation (GO:0007413)2.70677132
46microtubule severing (GO:0051013)2.69866834
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69678904
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68728529
49ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.67940484
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67361031
51nuclear pore organization (GO:0006999)2.67148922
52locomotory exploration behavior (GO:0035641)2.66122413
53coronary vasculature morphogenesis (GO:0060977)2.65478841
54striated muscle hypertrophy (GO:0014897)2.64749124
55membrane depolarization during action potential (GO:0086010)2.63609450
56positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.62954932
57piRNA metabolic process (GO:0034587)2.62528210
58response to pheromone (GO:0019236)2.62374672
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62171016
60regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.61823619
61histone lysine methylation (GO:0034968)2.61012765
62cardiac muscle contraction (GO:0060048)2.60922672
63nucleosome disassembly (GO:0006337)2.60412868
64protein-DNA complex disassembly (GO:0032986)2.60412868
65spermatid nucleus differentiation (GO:0007289)2.57093693
66regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57068301
67prepulse inhibition (GO:0060134)2.56950949
68dosage compensation (GO:0007549)2.54808563
69retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54727377
70histone H3-K4 trimethylation (GO:0080182)2.53167940
71outflow tract septum morphogenesis (GO:0003148)2.52818059
72regulation of glutamate receptor signaling pathway (GO:1900449)2.52139043
73sarcomere organization (GO:0045214)2.51469599
74cell communication by electrical coupling (GO:0010644)2.50706182
75regulation of sarcomere organization (GO:0060297)2.50243540
76positive regulation of potassium ion transmembrane transport (GO:1901381)2.50043481
77microtubule depolymerization (GO:0007019)2.49776649
78synaptic vesicle exocytosis (GO:0016079)2.49500142
79synaptic vesicle endocytosis (GO:0048488)2.49462349
80carnitine transmembrane transport (GO:1902603)2.49397813
81neuron cell-cell adhesion (GO:0007158)2.48598959
82synaptic vesicle maturation (GO:0016188)2.47895903
83sister chromatid segregation (GO:0000819)2.46856154
84positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46124197
85heart morphogenesis (GO:0003007)2.45388184
86mitotic sister chromatid segregation (GO:0000070)2.45139262
87acrosome reaction (GO:0007340)2.44922217
88RNA localization (GO:0006403)2.43608139
89mitotic sister chromatid cohesion (GO:0007064)2.43135313
90regulation of synapse maturation (GO:0090128)2.42705915
91actin filament-based movement (GO:0030048)2.40257420
92negative regulation of potassium ion transport (GO:0043267)2.40230354
93cardiac muscle hypertrophy in response to stress (GO:0014898)2.38976552
94muscle hypertrophy in response to stress (GO:0003299)2.38976552
95cardiac muscle adaptation (GO:0014887)2.38976552
96carnitine transport (GO:0015879)2.38802387
97amino-acid betaine transport (GO:0015838)2.38802387
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.38459215
99synaptic transmission, glutamatergic (GO:0035249)2.37728360
100establishment of protein localization to Golgi (GO:0072600)2.35886617
101cardiac conduction (GO:0061337)2.34538812
102protein retention in ER lumen (GO:0006621)2.34474471
103ionotropic glutamate receptor signaling pathway (GO:0035235)2.33447315
104actomyosin structure organization (GO:0031032)2.33183045
105protein targeting to Golgi (GO:0000042)2.33144062
106proline biosynthetic process (GO:0006561)2.32783276
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.31863956
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30620268
109positive regulation of cardiac muscle cell differentiation (GO:2000727)2.29738409
110central nervous system neuron axonogenesis (GO:0021955)2.29067341
111embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29047271
112ventricular cardiac muscle cell action potential (GO:0086005)2.28758040
113muscle cell fate commitment (GO:0042693)2.28585814
114glutamate receptor signaling pathway (GO:0007215)2.27883193
115Golgi transport vesicle coating (GO:0048200)2.27462802
116COPI coating of Golgi vesicle (GO:0048205)2.27462802
117response to auditory stimulus (GO:0010996)2.27064786
118auditory behavior (GO:0031223)2.27055443
119neuron-neuron synaptic transmission (GO:0007270)2.27043445
120centrosome duplication (GO:0051298)2.26795030
121body morphogenesis (GO:0010171)2.26607132
122protein localization to synapse (GO:0035418)2.26003335
123histone H3 deacetylation (GO:0070932)2.25255906
124regulation of histone H3-K4 methylation (GO:0051569)2.25021288
125COPII vesicle coating (GO:0048208)2.24651601
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.24612324
127neuron recognition (GO:0008038)2.24587305
128pore complex assembly (GO:0046931)2.24464862
129regulation of actin filament-based movement (GO:1903115)2.24455493
130negative regulation of potassium ion transmembrane transport (GO:1901380)2.24291274
131membrane repolarization (GO:0086009)2.24036230
132coenzyme catabolic process (GO:0009109)2.23483424
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.23252802
134detection of calcium ion (GO:0005513)2.22872703
135growth hormone secretion (GO:0030252)2.22786204
136regulation of potassium ion transmembrane transporter activity (GO:1901016)2.22358428
137creatine metabolic process (GO:0006600)2.22326235
138establishment of spindle orientation (GO:0051294)2.21749850
139membrane repolarization during action potential (GO:0086011)2.21560614
140long-term memory (GO:0007616)2.21376509
141calcium ion import (GO:0070509)2.21249093
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.21226869
143muscle hypertrophy (GO:0014896)2.20702082
144postsynaptic membrane organization (GO:0001941)2.20325932
145protein polyglutamylation (GO:0018095)2.20073807
146dendrite morphogenesis (GO:0048813)2.19926878
147regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.19845883
148regulation of potassium ion transmembrane transport (GO:1901379)2.19697291
149NADH metabolic process (GO:0006734)2.19578061
150DNA unwinding involved in DNA replication (GO:0006268)2.19418203
151response to inactivity (GO:0014854)2.19267919
152regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.19155288
153interkinetic nuclear migration (GO:0022027)2.18515856
154regulation of transforming growth factor beta2 production (GO:0032909)2.18321284
155positive regulation of cation channel activity (GO:2001259)2.18309446
156sarcoplasmic reticulum calcium ion transport (GO:0070296)2.17646668
157cardiac muscle cell development (GO:0055013)2.17168474
158positive regulation of potassium ion transport (GO:0043268)2.16885954
159pyrimidine nucleobase catabolic process (GO:0006208)2.15878434
160regulation of heart rate by cardiac conduction (GO:0086091)2.15835112
161sperm motility (GO:0030317)2.15828330
162glutamate secretion (GO:0014047)2.15286181
163centriole replication (GO:0007099)2.14349608
164striated muscle contraction (GO:0006941)2.14161053
165regulation of excitatory postsynaptic membrane potential (GO:0060079)2.13911777
166embryonic viscerocranium morphogenesis (GO:0048703)2.13672033
167regulation of synaptic transmission, glutamatergic (GO:0051966)2.12821543
168regulation of RNA export from nucleus (GO:0046831)2.12265768
169potassium ion export (GO:0071435)2.12163130
170regulation of neuronal synaptic plasticity (GO:0048168)2.11827195
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.11816543
172myoblast fusion (GO:0007520)2.11603027
173mechanosensory behavior (GO:0007638)2.11227041
174histone methylation (GO:0016571)2.10998292
175negative regulation of stem cell proliferation (GO:2000647)2.10782241
176fatty acid transmembrane transport (GO:1902001)2.08433863
177histone H3-K4 methylation (GO:0051568)2.08244928
178negative regulation of cell cycle G2/M phase transition (GO:1902750)2.07239450
179histone H4 deacetylation (GO:0070933)2.06242688
180peptidyl-lysine trimethylation (GO:0018023)2.04917341
181regulation of fatty acid beta-oxidation (GO:0031998)2.04643014
182negative regulation of autophagy (GO:0010507)2.04306725
183camera-type eye morphogenesis (GO:0048593)2.04157135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40402256
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.74938865
3GBX2_23144817_ChIP-Seq_PC3_Human3.39759083
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13784595
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66005689
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18365182
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14970060
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12147714
9E2F7_22180533_ChIP-Seq_HELA_Human2.10483634
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09396764
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01567703
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00462734
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00375613
14NFIB_24661679_ChIP-Seq_LUNG_Mouse1.99994896
15LXR_22292898_ChIP-Seq_THP-1_Human1.95422537
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95143103
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94657793
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93029272
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90167834
20DROSHA_22980978_ChIP-Seq_HELA_Human1.85877528
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83795395
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83795395
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82596294
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.82320750
25* KDM2B_26808549_Chip-Seq_K562_Human1.82097987
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81390561
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79611932
28VDR_21846776_ChIP-Seq_THP-1_Human1.77388506
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.75723630
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74221563
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73883258
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73851651
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.73153257
34CREB1_26743006_Chip-Seq_LNCaP_Human1.71677657
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.71169360
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71015096
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.69383244
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68160601
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65417667
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63201983
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63005424
42* EP300_21415370_ChIP-Seq_HL-1_Mouse1.60504265
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60267257
44REST_21632747_ChIP-Seq_MESCs_Mouse1.59179254
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58135588
46IGF1R_20145208_ChIP-Seq_DFB_Human1.57985506
47* SMC4_20622854_ChIP-Seq_HELA_Human1.57578798
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.56244630
49* RARB_27405468_Chip-Seq_BRAIN_Mouse1.54927759
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.54703251
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.53978095
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.53978095
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53618642
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52327134
55* CTCF_27219007_Chip-Seq_Bcells_Human1.50927301
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50343985
57RACK7_27058665_Chip-Seq_MCF-7_Human1.50090494
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48632784
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48435089
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48403707
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48297603
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47659255
63* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47599677
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47485427
65* STAT3_23295773_ChIP-Seq_U87_Human1.41965854
66* TCF4_23295773_ChIP-Seq_U87_Human1.40927102
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40129238
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39883900
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.39255457
70AR_21572438_ChIP-Seq_LNCaP_Human1.38156270
71KDM2B_26808549_Chip-Seq_DND41_Human1.38095617
72CIITA_25753668_ChIP-Seq_RAJI_Human1.37635286
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.37494979
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37486933
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36739220
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.36453038
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35839027
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35775664
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34895849
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34870149
81TCF7_22412390_ChIP-Seq_EML_Mouse1.34723742
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34490797
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34315699
84P68_20966046_ChIP-Seq_HELA_Human1.34298782
85ZNF263_19887448_ChIP-Seq_K562_Human1.33481507
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33328660
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33029480
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.32933231
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.32781553
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32746138
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32444473
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31557369
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31147303
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31147303
95* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30814808
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30785311
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29589982
98RNF2_27304074_Chip-Seq_NSC_Mouse1.29550615
99* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29084658
100AR_19668381_ChIP-Seq_PC3_Human1.29059159
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28675470
102AHR_22903824_ChIP-Seq_MCF-7_Human1.28500868
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.28262822
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28219991
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25765981
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25443677
107P300_19829295_ChIP-Seq_ESCs_Human1.25144384
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.24858917
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.22762127
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22587922
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21874339
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21720058
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20232252
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19578894
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.19445121
116AR_25329375_ChIP-Seq_VCAP_Human1.18735310
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.18536267
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18183288
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.17699391
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17597090
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17282989
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17261852
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16880976
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15730180
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15031159
126TET1_21451524_ChIP-Seq_MESCs_Mouse1.14647004
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13277384
128FOXM1_23109430_ChIP-Seq_U2OS_Human1.13009188
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12962346
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12898840
131SALL1_21062744_ChIP-ChIP_HESCs_Human1.12812274
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12517451
133CHD1_26751641_Chip-Seq_LNCaP_Human1.11770872
134* TP53_23651856_ChIP-Seq_MEFs_Mouse1.11392570
135ZNF274_21170338_ChIP-Seq_K562_Hela1.10845826
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10603490
137MYC_22102868_ChIP-Seq_BL_Human1.09639305
138FUS_26573619_Chip-Seq_HEK293_Human1.09519040
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09465642
140* REST_18959480_ChIP-ChIP_MESCs_Mouse1.08986458
141* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08283728
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08210000
143ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07655755
144ELK3_25401928_ChIP-Seq_HUVEC_Human1.07303292
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07250724
146* SA1_27219007_Chip-Seq_ERYTHROID_Human1.07233353
147DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07178748
148SOX9_26525672_Chip-Seq_HEART_Mouse1.07054101
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06910120
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06570335
151KDM5A_27292631_Chip-Seq_BREAST_Human1.06199899
152STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04759283
153TP63_22573176_ChIP-Seq_HFKS_Human1.04288364
154RING1B_27294783_Chip-Seq_ESCs_Mouse1.04261519
155* RUNX2_22187159_ChIP-Seq_PCA_Human1.03865309
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03564690
157CLOCK_20551151_ChIP-Seq_293T_Human1.02970806
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02765124
159ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01407578
160WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01050903
161RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99808866
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99107985
163RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98325144
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97845579
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97406911
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.96761501
167MYC_27129775_Chip-Seq_CORNEA_Mouse0.96668240
168KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96235122
169MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95845749
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95710569
171BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95149452
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94863191
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.94403011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.45554963
2MP0004859_abnormal_synaptic_plasticity2.99947302
3MP0000569_abnormal_digit_pigmentation2.66932018
4MP0000751_myopathy2.54326008
5MP0002009_preneoplasia2.51450108
6MP0003122_maternal_imprinting2.30892655
7MP0003787_abnormal_imprinting2.24359015
8MP0003646_muscle_fatigue2.15733564
9MP0000013_abnormal_adipose_tissue2.08179596
10MP0002837_dystrophic_cardiac_calcinosis2.06204923
11MP0005451_abnormal_body_composition2.05989884
12MP0004084_abnormal_cardiac_muscle2.05389102
13MP0010030_abnormal_orbit_morphology2.02445600
14MP0000003_abnormal_adipose_tissue1.95304260
15MP0004215_abnormal_myocardial_fiber1.94530041
16MP0004233_abnormal_muscle_weight1.92442722
17MP0005666_abnormal_adipose_tissue1.91107554
18MP0003635_abnormal_synaptic_transmissio1.90550735
19MP0000566_synostosis1.84178635
20MP0008438_abnormal_cutaneous_collagen1.82135104
21MP0005646_abnormal_pituitary_gland1.77852985
22MP0001984_abnormal_olfaction1.77486602
23MP0002063_abnormal_learning/memory/cond1.73719227
24MP0005375_adipose_tissue_phenotype1.70395557
25MP0003121_genomic_imprinting1.69137905
26MP0004036_abnormal_muscle_relaxation1.68050273
27MP0002234_abnormal_pharynx_morphology1.67998674
28MP0003880_abnormal_central_pattern1.64005004
29MP0004134_abnormal_chest_morphology1.63230470
30MP0005503_abnormal_tendon_morphology1.60892461
31MP0003705_abnormal_hypodermis_morpholog1.56001215
32MP0000749_muscle_degeneration1.55473698
33MP0008877_abnormal_DNA_methylation1.54811846
34MP0002572_abnormal_emotion/affect_behav1.52613753
35MP0005423_abnormal_somatic_nervous1.49624948
36MP0001188_hyperpigmentation1.47959545
37MP0000778_abnormal_nervous_system1.47427553
38MP0001661_extended_life_span1.46871099
39MP0010368_abnormal_lymphatic_system1.46196227
40MP0001486_abnormal_startle_reflex1.46050862
41MP0000733_abnormal_muscle_development1.46033903
42MP0010386_abnormal_urinary_bladder1.42920877
43MP0005248_abnormal_Harderian_gland1.42759133
44MP0003137_abnormal_impulse_conducting1.41069272
45MP0004085_abnormal_heartbeat1.39089461
46MP0001270_distended_abdomen1.36721627
47MP0009745_abnormal_behavioral_response1.34951285
48MP0000747_muscle_weakness1.34310573
49MP0004087_abnormal_muscle_fiber1.32207795
50MP0002249_abnormal_larynx_morphology1.29245427
51MP0005620_abnormal_muscle_contractility1.28197720
52MP0009780_abnormal_chondrocyte_physiolo1.26682744
53MP0004145_abnormal_muscle_electrophysio1.26475466
54MP0005367_renal/urinary_system_phenotyp1.25435707
55MP0000516_abnormal_urinary_system1.25435707
56MP0004185_abnormal_adipocyte_glucose1.24471572
57MP0002909_abnormal_adrenal_gland1.22768423
58MP0004130_abnormal_muscle_cell1.22370741
59MP0001502_abnormal_circadian_rhythm1.21830820
60MP0002108_abnormal_muscle_morphology1.21488777
61MP0004484_altered_response_of1.21081236
62MP0001299_abnormal_eye_distance/1.19459862
63MP0005410_abnormal_fertilization1.18519621
64MP0002638_abnormal_pupillary_reflex1.16465467
65MP0002972_abnormal_cardiac_muscle1.15928656
66MP0000534_abnormal_ureter_morphology1.15670139
67MP0010630_abnormal_cardiac_muscle1.15144338
68MP0008775_abnormal_heart_ventricle1.14797928
69MP0002184_abnormal_innervation1.13179946
70MP0003385_abnormal_body_wall1.13083528
71MP0009250_abnormal_appendicular_skeleto1.11946302
72MP0005409_darkened_coat_color1.11878293
73MP0003115_abnormal_respiratory_system1.11567546
74MP0009046_muscle_twitch1.11039694
75MP0002106_abnormal_muscle_physiology1.09391036
76* MP0002114_abnormal_axial_skeleton1.08874178
77MP0005369_muscle_phenotype1.08329143
78MP0000537_abnormal_urethra_morphology1.07606398
79MP0004270_analgesia1.07140023
80MP0000462_abnormal_digestive_system1.05963081
81MP0010094_abnormal_chromosome_stability1.05535249
82MP0002971_abnormal_brown_adipose1.05116957
83MP0005076_abnormal_cell_differentiation1.04837128
84MP0008961_abnormal_basal_metabolism1.04453721
85MP0005551_abnormal_eye_electrophysiolog1.03862306
86MP0002557_abnormal_social/conspecific_i1.03572002
87MP0002064_seizures1.03132762
88MP0002734_abnormal_mechanical_nocicepti1.02441420
89MP0001529_abnormal_vocalization1.01763717
90MP0001968_abnormal_touch/_nociception1.01038279
91MP0000678_abnormal_parathyroid_gland0.99172281
92MP0006138_congestive_heart_failure0.98019992
93MP0002822_catalepsy0.97827295
94MP0003935_abnormal_craniofacial_develop0.96873991
95MP0002876_abnormal_thyroid_physiology0.96790265
96MP0005330_cardiomyopathy0.96598909
97MP0003943_abnormal_hepatobiliary_system0.96289803
98MP0001879_abnormal_lymphatic_vessel0.95284885
99MP0002160_abnormal_reproductive_system0.95179330
100MP0002067_abnormal_sensory_capabilities0.94939515
101MP0008569_lethality_at_weaning0.94191911
102MP0000631_abnormal_neuroendocrine_gland0.94053862
103MP0008057_abnormal_DNA_replication0.93525778
104MP0002970_abnormal_white_adipose0.92869565
105MP0000750_abnormal_muscle_regeneration0.92299151
106* MP0003698_abnormal_male_reproductive0.91779846
107MP0006292_abnormal_olfactory_placode0.91648393
108MP0005187_abnormal_penis_morphology0.91603168
109MP0002116_abnormal_craniofacial_bone0.91182352
110MP0002282_abnormal_trachea_morphology0.90981139
111MP0003942_abnormal_urinary_system0.90496870
112MP0004924_abnormal_behavior0.90230200
113MP0005386_behavior/neurological_phenoty0.90230200
114MP0002166_altered_tumor_susceptibility0.90123893
115MP0002272_abnormal_nervous_system0.89218061
116MP0000759_abnormal_skeletal_muscle0.87834153
117MP0004811_abnormal_neuron_physiology0.86588009
118MP0008995_early_reproductive_senescence0.86137701
119MP0002127_abnormal_cardiovascular_syste0.86090762
120MP0003984_embryonic_growth_retardation0.85715027
121MP0002882_abnormal_neuron_morphology0.85458831
122* MP0001929_abnormal_gametogenesis0.85314618
123MP0000266_abnormal_heart_morphology0.85182045
124MP0001177_atelectasis0.85085240
125MP0002735_abnormal_chemical_nociception0.83791192
126MP0003279_aneurysm0.82908000
127MP0002736_abnormal_nociception_after0.82551741
128MP0000681_abnormal_thyroid_gland0.82322939
129MP0003119_abnormal_digestive_system0.82318989
130MP0003890_abnormal_embryonic-extraembry0.81669666
131MP0003045_fibrosis0.81122485
132MP0000049_abnormal_middle_ear0.80667717
133MP0002088_abnormal_embryonic_growth/wei0.80567487
134MP0003111_abnormal_nucleus_morphology0.80505559
135MP0002152_abnormal_brain_morphology0.79780050
136MP0005645_abnormal_hypothalamus_physiol0.79455517
137MP0002269_muscular_atrophy0.78813085
138MP0003948_abnormal_gas_homeostasis0.77041191
139MP0006276_abnormal_autonomic_nervous0.76813083
140MP0009384_cardiac_valve_regurgitation0.75589400
141MP0005380_embryogenesis_phenotype0.74609413
142MP0001672_abnormal_embryogenesis/_devel0.74609413
143MP0004858_abnormal_nervous_system0.70493777
144MP0003077_abnormal_cell_cycle0.69728746
145MP0003959_abnormal_lean_body0.69036413
146MP0004808_abnormal_hematopoietic_stem0.68738885
147MP0002210_abnormal_sex_determination0.67731658
148MP0005275_abnormal_skin_tensile0.67491149
149MP0000955_abnormal_spinal_cord0.65079241
150MP0002925_abnormal_cardiovascular_devel0.62355645
151MP0001348_abnormal_lacrimal_gland0.60745417
152MP0009278_abnormal_bone_marrow0.60404332
153* MP0001145_abnormal_male_reproductive0.59181098
154MP0005385_cardiovascular_system_phenoty0.59140278
155MP0001544_abnormal_cardiovascular_syste0.59140278
156MP0000163_abnormal_cartilage_morphology0.58593806

Predicted human phenotypes

RankGene SetZ-score
1Atrial fibrillation (HP:0005110)3.37045109
2Primary atrial arrhythmia (HP:0001692)3.25724572
3Asymmetric septal hypertrophy (HP:0001670)3.11807685
4Supraventricular tachycardia (HP:0004755)3.06913620
5Muscle fiber inclusion bodies (HP:0100299)2.98887088
6Supraventricular arrhythmia (HP:0005115)2.96354400
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.88756518
8Prolonged QT interval (HP:0001657)2.86519471
9Epileptic encephalopathy (HP:0200134)2.81938870
10Protrusio acetabuli (HP:0003179)2.78953695
11Nemaline bodies (HP:0003798)2.78570693
12Calcaneovalgus deformity (HP:0001848)2.71574390
13Exercise-induced myalgia (HP:0003738)2.68346940
14Myopathic facies (HP:0002058)2.65668175
15Febrile seizures (HP:0002373)2.61324736
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57774368
17Short 4th metacarpal (HP:0010044)2.57774368
18Sudden death (HP:0001699)2.56619446
19Abnormality of the calcaneus (HP:0008364)2.52793472
20Subaortic stenosis (HP:0001682)2.52070306
21Abnormality of the left ventricular outflow tract (HP:0011103)2.52070306
22Myoglobinuria (HP:0002913)2.51245807
23Mildly elevated creatine phosphokinase (HP:0008180)2.50427897
24Abnormality of the right ventricle (HP:0001707)2.43005512
25Abnormality of the calf musculature (HP:0001430)2.42825745
26Bell-shaped thorax (HP:0001591)2.38486899
27Abnormal EKG (HP:0003115)2.33847024
28Central scotoma (HP:0000603)2.32923155
29Hyperkalemia (HP:0002153)2.32404058
30Focal motor seizures (HP:0011153)2.28167078
31Astrocytoma (HP:0009592)2.27710610
32Abnormality of the astrocytes (HP:0100707)2.27710610
33Deformed tarsal bones (HP:0008119)2.27692130
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.23857535
35Papillary thyroid carcinoma (HP:0002895)2.23508151
36Rimmed vacuoles (HP:0003805)2.19357632
37Tubulointerstitial nephritis (HP:0001970)2.19253416
38Genetic anticipation (HP:0003743)2.19137919
39Calf muscle hypertrophy (HP:0008981)2.16904125
40Nephronophthisis (HP:0000090)2.16351261
41Abnormality of the fingertips (HP:0001211)2.15184763
42Heterotopia (HP:0002282)2.13628833
43Neoplasm of the heart (HP:0100544)2.12986480
44Distal arthrogryposis (HP:0005684)2.09476523
45Renovascular hypertension (HP:0100817)2.07490760
46Absent/shortened dynein arms (HP:0200106)2.06946773
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.06946773
48Abnormality of skeletal muscle fiber size (HP:0012084)2.03669928
49Spinal rigidity (HP:0003306)2.03009668
50Progressive cerebellar ataxia (HP:0002073)2.01810882
51Renal duplication (HP:0000075)2.00604767
52Abnormal hair whorl (HP:0010721)1.97095642
53Acute myeloid leukemia (HP:0004808)1.96657574
54Narrow palate (HP:0000189)1.94481220
55Hepatoblastoma (HP:0002884)1.93708765
56Sandal gap (HP:0001852)1.93621789
57Syncope (HP:0001279)1.93445825
58Broad-based gait (HP:0002136)1.93160524
59Rhabdomyolysis (HP:0003201)1.92305648
60Increased connective tissue (HP:0009025)1.91405412
61Glioma (HP:0009733)1.90242026
62Hyporeflexia of lower limbs (HP:0002600)1.90196854
63Midline defect of the nose (HP:0004122)1.89860088
64Abnormality of the aortic arch (HP:0012303)1.89709171
65Truncal obesity (HP:0001956)1.88307367
66Muscle hypertrophy of the lower extremities (HP:0008968)1.87132145
67Lymphangioma (HP:0100764)1.86118579
68Abnormality of the nasal septum (HP:0000419)1.84044160
69Cerebral aneurysm (HP:0004944)1.82829286
70Dilated cardiomyopathy (HP:0001644)1.82568849
71Precocious puberty (HP:0000826)1.79951510
72Round ear (HP:0100830)1.79926382
73Abnormal tarsal ossification (HP:0008369)1.79685574
74Obsessive-compulsive behavior (HP:0000722)1.78720217
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78224680
76Flat acetabular roof (HP:0003180)1.76918250
77Shallow orbits (HP:0000586)1.76154583
78Broad face (HP:0000283)1.76102523
79Ventricular fibrillation (HP:0001663)1.75528518
80Macroorchidism (HP:0000053)1.73597046
81Focal seizures (HP:0007359)1.73093502
82Rhizomelia (HP:0008905)1.73070519
83Abnormality of midbrain morphology (HP:0002418)1.71687355
84Molar tooth sign on MRI (HP:0002419)1.71687355
85Abnormality of the thoracic spine (HP:0100711)1.71373463
86Aortic aneurysm (HP:0004942)1.71232620
87EMG: myopathic abnormalities (HP:0003458)1.71056459
88Sparse lateral eyebrow (HP:0005338)1.70656157
89Arterial tortuosity (HP:0005116)1.70531416
90Abnormality of the 4th metacarpal (HP:0010012)1.70188997
91EMG: neuropathic changes (HP:0003445)1.70115685
92Atonic seizures (HP:0010819)1.69298772
93Self-mutilation (HP:0000742)1.68409147
94Spinal canal stenosis (HP:0003416)1.67928113
95Ependymoma (HP:0002888)1.67061630
96Volvulus (HP:0002580)1.66622855
97Mesomelia (HP:0003027)1.66075144
98Trigonocephaly (HP:0000243)1.66048460
99Open mouth (HP:0000194)1.65792086
100Progressive sensorineural hearing impairment (HP:0000408)1.64987270
101Hip dysplasia (HP:0001385)1.64785771
102Upper limb amyotrophy (HP:0009129)1.64215525
103Distal upper limb amyotrophy (HP:0007149)1.64215525
104Uterine leiomyosarcoma (HP:0002891)1.64032072
105Leiomyosarcoma (HP:0100243)1.64032072
106Bulbar palsy (HP:0001283)1.63472651
107Ventricular arrhythmia (HP:0004308)1.63350513
108Asymmetry of the thorax (HP:0001555)1.63009819
109Abnormality of dentin (HP:0010299)1.62511416
110Hip contracture (HP:0003273)1.62342886
111Abnormality of the acetabulum (HP:0003170)1.62243904
112Left ventricular hypertrophy (HP:0001712)1.62124498
113Abnormality of the pubic bones (HP:0003172)1.62043330
114Long clavicles (HP:0000890)1.61812060
115Vascular tortuosity (HP:0004948)1.61136532
116Anteriorly placed anus (HP:0001545)1.59862543
117Metatarsus adductus (HP:0001840)1.59556072
118Abnormality of the renal medulla (HP:0100957)1.59335266
119Dislocated radial head (HP:0003083)1.58824980
120Ulnar deviation of the wrist (HP:0003049)1.58158682
121Dysmetric saccades (HP:0000641)1.58138380
122Ventricular tachycardia (HP:0004756)1.57952393
123Disproportionate tall stature (HP:0001519)1.57575610
124Excessive salivation (HP:0003781)1.57019993
125Drooling (HP:0002307)1.57019993
126Gaze-evoked nystagmus (HP:0000640)1.56496540
127Atelectasis (HP:0100750)1.55837773
128Tented upper lip vermilion (HP:0010804)1.55684983
129Elfin facies (HP:0004428)1.55061568
130Hypoparathyroidism (HP:0000829)1.54793856
131Neoplasm of the adrenal cortex (HP:0100641)1.54102228
132Abnormal ventriculo-arterial connection (HP:0011563)1.53924132
133Transposition of the great arteries (HP:0001669)1.53924132
134Abnormal connection of the cardiac segments (HP:0011545)1.53924132
135Scapular winging (HP:0003691)1.53794463
136Hypoventilation (HP:0002791)1.53147859
137Bradycardia (HP:0001662)1.53084789
138Decreased circulating renin level (HP:0003351)1.52799184
139Flattened epiphyses (HP:0003071)1.52156525
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.51984301
14111 pairs of ribs (HP:0000878)1.51494832
142Hypoplastic ischia (HP:0003175)1.51375995
143High pitched voice (HP:0001620)1.51103575
144Menstrual irregularities (HP:0000858)1.51030976
145Dental malocclusion (HP:0000689)1.50893820
146Thin ribs (HP:0000883)1.50564613
147Deep philtrum (HP:0002002)1.50414198
148Long eyelashes (HP:0000527)1.50342371
149Lipoatrophy (HP:0100578)1.49985351
150Right ventricular cardiomyopathy (HP:0011663)1.49313166
151Hand muscle atrophy (HP:0009130)1.49226884
152Hyperthyroidism (HP:0000836)1.49203502
153Cutaneous finger syndactyly (HP:0010554)1.49037392
154Acute lymphatic leukemia (HP:0006721)1.48922221
155Hemangiomatosis (HP:0007461)1.48899815
156Polycystic kidney dysplasia (HP:0000113)1.48889802
157Exercise-induced muscle cramps (HP:0003710)1.48781495
158Abnormal ossification of hand bones (HP:0005921)1.48766658
159Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.48664773
160Protruding tongue (HP:0010808)1.47350439
161Type 1 muscle fiber predominance (HP:0003803)1.47346969
162Narrow nasal bridge (HP:0000446)1.47156011
163Hyperacusis (HP:0010780)1.46850490
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46453498
165Broad palm (HP:0001169)1.46425552
166Widely spaced teeth (HP:0000687)1.46183371
167Increased variability in muscle fiber diameter (HP:0003557)1.45613220
168Broad metatarsal (HP:0001783)1.45566561
169Bundle branch block (HP:0011710)1.45026760
170Urinary bladder sphincter dysfunction (HP:0002839)1.43181487
171Flat cornea (HP:0007720)1.42815755
172Male infertility (HP:0003251)1.41510758
173Abnormal pancreas size (HP:0012094)1.41389104
174Osteomalacia (HP:0002749)1.41100960
175Postural instability (HP:0002172)1.40654302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.29644830
2EEF2K3.19713580
3TAOK23.01026540
4NTRK32.94245584
5PRKD32.90211834
6PKN22.81457353
7ICK2.75970439
8PRPF4B2.44960694
9STK38L2.20550599
10PLK42.04638825
11LATS11.99521408
12EPHA41.97653507
13SIK31.95791526
14OBSCN1.94523111
15MAP3K41.83921361
16KSR11.82950371
17FLT31.79280171
18DMPK1.77791886
19LMTK21.73140597
20STK241.73025931
21MYLK1.70273508
22CASK1.64812607
23TAOK11.62944482
24MARK11.57745388
25MAP2K71.55466715
26STK381.55364872
27TNIK1.52268925
28CDK81.49679661
29SGK21.42580123
30CDC42BPA1.42367441
31PHKG11.40515149
32PHKG21.40515149
33PDK41.40205986
34PDK31.40205986
35NEK21.33558878
36SGK31.31556691
37BRD41.31362686
38SIK11.29790835
39INSRR1.28434667
40LATS21.27170280
41CDK121.23496201
42AKT31.20457175
43PAK61.19251631
44MAP2K31.16211462
45MAPK131.15850643
46PTK2B1.15453431
47MAPK111.12972536
48CAMK1G1.12953288
49NTRK21.12722426
50MAP3K91.09639299
51PRKAA21.07661136
52MARK21.07227367
53TYRO31.06113059
54TTN0.96015633
55MINK10.95153716
56CHEK20.93778564
57ERBB30.90735424
58EPHB20.87649881
59PDGFRA0.84442171
60WNK10.83469437
61PRKAA10.83274610
62PIK3CA0.82768011
63MAP3K120.81509871
64SGK10.80284162
65MAPK120.80112377
66FGFR40.79976599
67SGK2230.79879786
68SGK4940.79879786
69CAMK10.79514023
70ADRBK20.78406783
71PINK10.77757269
72CDK70.76909136
73CAMKK10.76724841
74FGFR30.76351997
75PIK3CG0.76218388
76DDR20.75410175
77WNK40.75305982
78CAMK1D0.74621247
79PLK20.74062443
80RIPK10.70007680
81RPS6KA20.69698332
82SIK20.68801338
83FGFR20.67847302
84CAMK40.67810568
85PDK20.67692091
86TRPM70.67283949
87RPS6KA60.67273664
88CHEK10.67247231
89ERN10.67162065
90MUSK0.65534813
91ATR0.65102292
92DAPK20.64954124
93ZAK0.64927247
94MAP3K20.63726318
95PRKCH0.63385350
96CCNB10.62596725
97CDK20.62373662
98PRKD20.62269955
99MAP3K70.62247993
100RET0.61792757
101PRKCE0.60914329
102CDK30.60797988
103DAPK10.59984760
104PTK20.59402435
105CDK10.59143373
106PDPK10.58553982
107CDK50.57714741
108ROCK10.57615173
109MAP3K50.57253519
110NEK90.56114040
111MET0.55783898
112NUAK10.55254628
113STK30.54139754
114MAP3K60.52664149
115PAK20.51514858
116MAPK10.51175470
117CAMKK20.50741561
118RPS6KB10.49650429
119RPS6KA10.48694844
120PAK30.47821139
121MTOR0.47134735
122PDK10.46446966
123CDK40.46016621
124MAPK140.45902644
125GSK3B0.45888225
126PRKDC0.45422898
127CAMK2A0.45355229
128SMG10.44523546
129MAP2K40.41763325
130DYRK1B0.41135509
131MAPK80.41116170
132MAP2K20.40079269
133MAP4K20.39433072
134UHMK10.39376896
135ATM0.39245623
136BRSK10.39214303
137PRKD10.38335062
138AKT10.37767899
139PDGFRB0.37350513
140KIT0.36695366
141RPS6KA30.36595578
142MAPK40.35962276
143RPS6KL10.35469463
144RPS6KC10.35469463
145PRKACB0.35215206
146DYRK1A0.33606525
147PRKG10.33282132
148FGFR10.32920506
149MAPK100.30839083

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.16682772
2Dilated cardiomyopathy_Homo sapiens_hsa054142.15290025
3Circadian entrainment_Homo sapiens_hsa047132.08143148
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.03232468
5Nicotine addiction_Homo sapiens_hsa050332.00832102
6Fatty acid biosynthesis_Homo sapiens_hsa000611.95925254
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.94038182
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90721535
9Fatty acid metabolism_Homo sapiens_hsa012121.89299242
10Morphine addiction_Homo sapiens_hsa050321.88035788
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76511232
12Insulin secretion_Homo sapiens_hsa049111.75825961
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72295638
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70047455
15Renin secretion_Homo sapiens_hsa049241.66437853
16Glutamatergic synapse_Homo sapiens_hsa047241.65804181
17Amphetamine addiction_Homo sapiens_hsa050311.63826088
18Taste transduction_Homo sapiens_hsa047421.62879379
19Long-term potentiation_Homo sapiens_hsa047201.60950020
20GABAergic synapse_Homo sapiens_hsa047271.58391635
21Synaptic vesicle cycle_Homo sapiens_hsa047211.57333540
22Dopaminergic synapse_Homo sapiens_hsa047281.56750270
23Oxytocin signaling pathway_Homo sapiens_hsa049211.53487372
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49810292
25Calcium signaling pathway_Homo sapiens_hsa040201.49541123
26Sulfur relay system_Homo sapiens_hsa041221.49328142
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.47769138
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46270799
29Cholinergic synapse_Homo sapiens_hsa047251.43509962
30Cocaine addiction_Homo sapiens_hsa050301.38462650
31Endometrial cancer_Homo sapiens_hsa052131.34202710
32Vitamin B6 metabolism_Homo sapiens_hsa007501.33630438
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.29603471
34cAMP signaling pathway_Homo sapiens_hsa040241.26829586
35Phenylalanine metabolism_Homo sapiens_hsa003601.23609111
36Circadian rhythm_Homo sapiens_hsa047101.22860818
37Type II diabetes mellitus_Homo sapiens_hsa049301.22097552
38Axon guidance_Homo sapiens_hsa043601.21221425
39Salivary secretion_Homo sapiens_hsa049701.20948488
40Cardiac muscle contraction_Homo sapiens_hsa042601.19524640
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18138537
42Fatty acid degradation_Homo sapiens_hsa000711.15391005
43Gastric acid secretion_Homo sapiens_hsa049711.14317835
44GnRH signaling pathway_Homo sapiens_hsa049121.13645856
45Serotonergic synapse_Homo sapiens_hsa047261.13523439
46Gap junction_Homo sapiens_hsa045401.13459295
47Basal cell carcinoma_Homo sapiens_hsa052171.12730120
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12377225
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11866678
50Colorectal cancer_Homo sapiens_hsa052101.11165577
51Carbon metabolism_Homo sapiens_hsa012001.07740830
52Propanoate metabolism_Homo sapiens_hsa006401.07657739
53Hedgehog signaling pathway_Homo sapiens_hsa043401.06961227
54Arginine biosynthesis_Homo sapiens_hsa002201.06855973
55Long-term depression_Homo sapiens_hsa047301.04981408
56Adherens junction_Homo sapiens_hsa045201.03878565
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03782965
58Biosynthesis of amino acids_Homo sapiens_hsa012301.03613861
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.03598141
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02265732
61Glucagon signaling pathway_Homo sapiens_hsa049221.02110093
62ErbB signaling pathway_Homo sapiens_hsa040121.01411857
63Wnt signaling pathway_Homo sapiens_hsa043101.00027775
64Glioma_Homo sapiens_hsa052140.99587606
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98322487
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97490414
67Butanoate metabolism_Homo sapiens_hsa006500.95940518
68Estrogen signaling pathway_Homo sapiens_hsa049150.95446186
69Dorso-ventral axis formation_Homo sapiens_hsa043200.95054961
70MAPK signaling pathway_Homo sapiens_hsa040100.94784265
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93084346
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92951498
73Arginine and proline metabolism_Homo sapiens_hsa003300.92747921
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92689808
75N-Glycan biosynthesis_Homo sapiens_hsa005100.92454381
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90565853
77Oocyte meiosis_Homo sapiens_hsa041140.89832567
78Melanogenesis_Homo sapiens_hsa049160.89152685
79Focal adhesion_Homo sapiens_hsa045100.88843760
80mTOR signaling pathway_Homo sapiens_hsa041500.88765258
81Hippo signaling pathway_Homo sapiens_hsa043900.86791145
82Base excision repair_Homo sapiens_hsa034100.82699222
83Prostate cancer_Homo sapiens_hsa052150.81329014
84Insulin signaling pathway_Homo sapiens_hsa049100.81317544
85Acute myeloid leukemia_Homo sapiens_hsa052210.80269091
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80013512
87mRNA surveillance pathway_Homo sapiens_hsa030150.78418446
88Fat digestion and absorption_Homo sapiens_hsa049750.77289617
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77022859
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76365049
91Non-small cell lung cancer_Homo sapiens_hsa052230.75289261
92Rap1 signaling pathway_Homo sapiens_hsa040150.74032323
93Notch signaling pathway_Homo sapiens_hsa043300.73763339
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.73551578
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72731786
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.72052933
97Phototransduction_Homo sapiens_hsa047440.71956596
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70380550
99Chronic myeloid leukemia_Homo sapiens_hsa052200.70116963
100Lysine degradation_Homo sapiens_hsa003100.69683571
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69597421
102Tyrosine metabolism_Homo sapiens_hsa003500.68958014
103Fanconi anemia pathway_Homo sapiens_hsa034600.68893514
104Renin-angiotensin system_Homo sapiens_hsa046140.68427783
105Choline metabolism in cancer_Homo sapiens_hsa052310.67138053
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66515341
107ECM-receptor interaction_Homo sapiens_hsa045120.66465488
108Other glycan degradation_Homo sapiens_hsa005110.63841947
109PPAR signaling pathway_Homo sapiens_hsa033200.63739102
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.63738378
111Protein digestion and absorption_Homo sapiens_hsa049740.63655254
112Pyruvate metabolism_Homo sapiens_hsa006200.62107910
113beta-Alanine metabolism_Homo sapiens_hsa004100.62062017
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62009624
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61778544
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61510307
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.61156177
118Ras signaling pathway_Homo sapiens_hsa040140.60268371
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.60075907
120Insulin resistance_Homo sapiens_hsa049310.60005410
121Inositol phosphate metabolism_Homo sapiens_hsa005620.59491066
122AMPK signaling pathway_Homo sapiens_hsa041520.59170846
123Melanoma_Homo sapiens_hsa052180.58534655
124Platelet activation_Homo sapiens_hsa046110.58441160
125VEGF signaling pathway_Homo sapiens_hsa043700.57667303
126Proteoglycans in cancer_Homo sapiens_hsa052050.57305912
127Pathways in cancer_Homo sapiens_hsa052000.57046222
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56803323
129Tight junction_Homo sapiens_hsa045300.56453999
130MicroRNAs in cancer_Homo sapiens_hsa052060.56414606
131Pancreatic secretion_Homo sapiens_hsa049720.55538333
132Cell cycle_Homo sapiens_hsa041100.55292957
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55194321
134Ovarian steroidogenesis_Homo sapiens_hsa049130.54097115
135Fructose and mannose metabolism_Homo sapiens_hsa000510.53933013
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53002214
137Pancreatic cancer_Homo sapiens_hsa052120.52965909
138FoxO signaling pathway_Homo sapiens_hsa040680.52452288
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52084052
140Thyroid hormone synthesis_Homo sapiens_hsa049180.51367168
141Vibrio cholerae infection_Homo sapiens_hsa051100.50136889
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49648775

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