SCLY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.20549167
2L-phenylalanine catabolic process (GO:0006559)7.20549167
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.92981529
4L-phenylalanine metabolic process (GO:0006558)6.92981529
5aromatic amino acid family catabolic process (GO:0009074)6.43545509
6indole-containing compound catabolic process (GO:0042436)5.74121312
7indolalkylamine catabolic process (GO:0046218)5.74121312
8tryptophan catabolic process (GO:0006569)5.74121312
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.65802202
10glyoxylate metabolic process (GO:0046487)5.62859037
11kynurenine metabolic process (GO:0070189)5.62390660
12tryptophan metabolic process (GO:0006568)5.50709951
13bile acid biosynthetic process (GO:0006699)5.24943491
14cysteine metabolic process (GO:0006534)5.23494881
15alpha-linolenic acid metabolic process (GO:0036109)5.20555135
16behavioral response to nicotine (GO:0035095)5.19096196
17high-density lipoprotein particle remodeling (GO:0034375)5.15265657
18sulfur amino acid catabolic process (GO:0000098)5.12174338
19urea cycle (GO:0000050)5.08845169
20urea metabolic process (GO:0019627)5.08845169
21tyrosine metabolic process (GO:0006570)4.98547916
22DNA deamination (GO:0045006)4.97161209
23lysine metabolic process (GO:0006553)4.89596680
24lysine catabolic process (GO:0006554)4.89596680
25protein carboxylation (GO:0018214)4.84407473
26peptidyl-glutamic acid carboxylation (GO:0017187)4.84407473
27negative regulation of fibrinolysis (GO:0051918)4.82779549
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81632132
29aromatic amino acid family metabolic process (GO:0009072)4.81582041
30nitrogen cycle metabolic process (GO:0071941)4.67844482
31bile acid metabolic process (GO:0008206)4.64103321
32serine family amino acid catabolic process (GO:0009071)4.63347753
33complement activation, alternative pathway (GO:0006957)4.62641514
34regulation of fibrinolysis (GO:0051917)4.61031896
35homocysteine metabolic process (GO:0050667)4.58039886
36reverse cholesterol transport (GO:0043691)4.55656252
37regulation of protein activation cascade (GO:2000257)4.52918887
38regulation of cholesterol esterification (GO:0010872)4.38203105
39plasma lipoprotein particle remodeling (GO:0034369)4.35023580
40protein-lipid complex remodeling (GO:0034368)4.35023580
41macromolecular complex remodeling (GO:0034367)4.35023580
42phospholipid efflux (GO:0033700)4.34742455
43alpha-amino acid catabolic process (GO:1901606)4.34084895
44regulation of triglyceride catabolic process (GO:0010896)4.31883599
45amino-acid betaine metabolic process (GO:0006577)4.31101120
46triglyceride homeostasis (GO:0070328)4.25083646
47acylglycerol homeostasis (GO:0055090)4.25083646
48negative regulation of cholesterol transport (GO:0032375)4.23552156
49negative regulation of sterol transport (GO:0032372)4.23552156
50regulation of complement activation (GO:0030449)4.21182218
51indolalkylamine metabolic process (GO:0006586)4.19054459
52cellular ketone body metabolic process (GO:0046950)4.08890218
53cellular modified amino acid catabolic process (GO:0042219)4.07970602
54cellular amino acid catabolic process (GO:0009063)4.05280458
55plasma lipoprotein particle clearance (GO:0034381)4.04841798
56coenzyme catabolic process (GO:0009109)4.03000220
57glutamate metabolic process (GO:0006536)4.01331498
58glycine metabolic process (GO:0006544)3.99728859
59serine family amino acid metabolic process (GO:0009069)3.94595302
60bile acid and bile salt transport (GO:0015721)3.92761545
61aldehyde catabolic process (GO:0046185)3.91069827
62cholesterol efflux (GO:0033344)3.90752677
63drug transmembrane transport (GO:0006855)3.90714982
64regulation of gene silencing by RNA (GO:0060966)3.90536877
65regulation of posttranscriptional gene silencing (GO:0060147)3.90536877
66regulation of gene silencing by miRNA (GO:0060964)3.90536877
67cellular biogenic amine catabolic process (GO:0042402)3.90412889
68amine catabolic process (GO:0009310)3.90412889
69imidazole-containing compound metabolic process (GO:0052803)3.87434093
70short-chain fatty acid metabolic process (GO:0046459)3.83607503
71benzene-containing compound metabolic process (GO:0042537)3.82354108
72serine family amino acid biosynthetic process (GO:0009070)3.80375283
73drug catabolic process (GO:0042737)3.79807782
74dicarboxylic acid biosynthetic process (GO:0043650)3.79641429
75urate metabolic process (GO:0046415)3.78807538
76plasma lipoprotein particle assembly (GO:0034377)3.77936338
77regulation of cholesterol homeostasis (GO:2000188)3.77898688
78ketone body metabolic process (GO:1902224)3.77766493
79cellular glucuronidation (GO:0052695)3.71263507
80phospholipid homeostasis (GO:0055091)3.68350006
81aspartate family amino acid catabolic process (GO:0009068)3.62265280
822-oxoglutarate metabolic process (GO:0006103)3.62241192
83organic acid catabolic process (GO:0016054)3.56795273
84carboxylic acid catabolic process (GO:0046395)3.56795273
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.56792510
86NADH dehydrogenase complex assembly (GO:0010257)3.56792510
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56792510
88valine metabolic process (GO:0006573)3.56728451
89ethanol oxidation (GO:0006069)3.54424813
90protein polyglutamylation (GO:0018095)3.54143743
91water-soluble vitamin biosynthetic process (GO:0042364)3.52919700
92sperm motility (GO:0030317)3.52900039
93cofactor catabolic process (GO:0051187)3.52389791
94fatty acid oxidation (GO:0019395)3.51761863
95cholesterol homeostasis (GO:0042632)3.49926810
96arginine metabolic process (GO:0006525)3.48891898
97regulation of nuclear cell cycle DNA replication (GO:0033262)3.48409604
98low-density lipoprotein particle remodeling (GO:0034374)3.47624078
99sterol homeostasis (GO:0055092)3.47511925
100L-fucose catabolic process (GO:0042355)3.46503737
101fucose catabolic process (GO:0019317)3.46503737
102L-fucose metabolic process (GO:0042354)3.46503737
103positive regulation of triglyceride lipase activity (GO:0061365)3.46376734
104positive regulation of lipoprotein lipase activity (GO:0051006)3.46376734
105lipid oxidation (GO:0034440)3.44919088
106fatty acid beta-oxidation (GO:0006635)3.42324171
107acetyl-CoA metabolic process (GO:0006084)3.42150800
108fibrinolysis (GO:0042730)3.41991597
109plasma lipoprotein particle organization (GO:0071827)3.41947954
110protein-lipid complex assembly (GO:0065005)3.41562573
111blood coagulation, intrinsic pathway (GO:0007597)3.40979687
112intestinal cholesterol absorption (GO:0030299)3.40247262
113lipoprotein metabolic process (GO:0042157)3.39433710
114regulation of bile acid biosynthetic process (GO:0070857)3.39355638
115positive regulation of lipid catabolic process (GO:0050996)3.36685719
116indole-containing compound metabolic process (GO:0042430)3.36382499
117piRNA metabolic process (GO:0034587)3.33766210
118regulation of action potential (GO:0098900)3.32921436
119protein complex biogenesis (GO:0070271)3.32675797
120multicellular organism reproduction (GO:0032504)3.28139720
121response to pheromone (GO:0019236)3.25621105
122detection of light stimulus involved in visual perception (GO:0050908)3.20016895
123detection of light stimulus involved in sensory perception (GO:0050962)3.20016895
124DNA methylation involved in gamete generation (GO:0043046)3.19667951
125sulfation (GO:0051923)3.18240869
126mitochondrial respiratory chain complex assembly (GO:0033108)3.17577774
127fusion of sperm to egg plasma membrane (GO:0007342)3.13516357
128pseudouridine synthesis (GO:0001522)3.10958711
129primary amino compound metabolic process (GO:1901160)3.10649259
130NAD biosynthetic process (GO:0009435)3.03023149
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00976087
132replication fork processing (GO:0031297)2.98075631
133regulation of hippo signaling (GO:0035330)2.97419433
134negative regulation of telomere maintenance (GO:0032205)2.96724158
135recombinational repair (GO:0000725)2.95108702
136double-strand break repair via homologous recombination (GO:0000724)2.95080207
137oxidative demethylation (GO:0070989)2.90844057
138positive regulation of action potential (GO:0045760)2.88990843
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87981802
140DNA replication checkpoint (GO:0000076)2.86042618
141serotonin metabolic process (GO:0042428)2.84652611
142neuronal action potential (GO:0019228)2.82053112
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81054431
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.81054431
145regulation of translation, ncRNA-mediated (GO:0045974)2.81054431
146regulation of mesoderm development (GO:2000380)2.80661690
147male meiosis I (GO:0007141)2.75283004
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72824952
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66775009
150preassembly of GPI anchor in ER membrane (GO:0016254)2.65050690
151reflex (GO:0060004)2.63465045
152sperm-egg recognition (GO:0035036)2.57324969
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55908144
154regulation of acrosome reaction (GO:0060046)2.55392259
155respiratory chain complex IV assembly (GO:0008535)2.55261203
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53189627
157spinal cord motor neuron differentiation (GO:0021522)2.53080528
158spermatid development (GO:0007286)2.52564900
159acrosome reaction (GO:0007340)2.51995097
160somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51159132
161somatic hypermutation of immunoglobulin genes (GO:0016446)2.51159132
162centriole replication (GO:0007099)2.50812696
163reciprocal DNA recombination (GO:0035825)2.50288965
164reciprocal meiotic recombination (GO:0007131)2.50288965
165protein-cofactor linkage (GO:0018065)2.49800894
166response to misfolded protein (GO:0051788)2.48540210
167DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.48439883
168mannosylation (GO:0097502)2.48232584
169cilium or flagellum-dependent cell motility (GO:0001539)2.48220598
170peristalsis (GO:0030432)2.48108540
171tRNA modification (GO:0006400)2.47216693
172rRNA modification (GO:0000154)2.47042583
173regulation of cilium movement (GO:0003352)2.46992271
174meiotic chromosome segregation (GO:0045132)2.46021458
175cell proliferation in forebrain (GO:0021846)2.45886067
176maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44385133
177negative regulation of DNA-dependent DNA replication (GO:2000104)2.43777919
178regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43520999
179epithelial cilium movement (GO:0003351)2.43422917
180regulation of female gonad development (GO:2000194)2.43419392
181DNA modification (GO:0006304)2.43275116
182cellular response to ATP (GO:0071318)2.42438803
183rhodopsin mediated signaling pathway (GO:0016056)2.41726410
184tRNA processing (GO:0008033)2.40597935
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39690126
186RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39690126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.79463322
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.76115292
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.13734033
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.07140924
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80490946
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62168928
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.41358486
8EZH2_22144423_ChIP-Seq_EOC_Human4.06901738
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.82639142
10ZNF274_21170338_ChIP-Seq_K562_Hela3.79543037
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67206481
12VDR_22108803_ChIP-Seq_LS180_Human3.34736653
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77041391
14GBX2_23144817_ChIP-Seq_PC3_Human2.35147496
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32520774
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31756208
17GATA1_22025678_ChIP-Seq_K562_Human2.29525181
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27826964
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22666554
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.21571116
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21438999
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11516335
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09646640
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.03708978
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8902068
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99066535
27* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98600821
28FUS_26573619_Chip-Seq_HEK293_Human1.90888903
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.89439727
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86252504
31IRF1_19129219_ChIP-ChIP_H3396_Human1.83039519
32EWS_26573619_Chip-Seq_HEK293_Human1.78445448
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76842846
34IGF1R_20145208_ChIP-Seq_DFB_Human1.76049471
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70726184
36ER_23166858_ChIP-Seq_MCF-7_Human1.67220060
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63981156
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.62675082
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61896516
40P300_19829295_ChIP-Seq_ESCs_Human1.58783389
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.57954196
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.55940907
43CLOCK_20551151_ChIP-Seq_293T_Human1.54849978
44* MYC_18940864_ChIP-ChIP_HL60_Human1.54434651
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.50452167
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47605909
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46652948
48TP53_22573176_ChIP-Seq_HFKS_Human1.46576523
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45629650
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45198914
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43203007
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43078724
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43078724
54* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41225024
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39252473
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39232115
57REST_21632747_ChIP-Seq_MESCs_Mouse1.38899156
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38199826
59* GATA3_21878914_ChIP-Seq_MCF-7_Human1.36051021
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35732272
61CBP_20019798_ChIP-Seq_JUKART_Human1.35732272
62STAT3_23295773_ChIP-Seq_U87_Human1.35452803
63* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34624477
64* FOXA1_25329375_ChIP-Seq_VCAP_Human1.34624477
65ERA_21632823_ChIP-Seq_H3396_Human1.31633179
66TAF15_26573619_Chip-Seq_HEK293_Human1.27774939
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27678580
68NANOG_20526341_ChIP-Seq_ESCs_Human1.26813280
69TCF4_23295773_ChIP-Seq_U87_Human1.25501501
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.25195450
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.23818165
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23760676
73NCOR_22424771_ChIP-Seq_293T_Human1.23015417
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21081281
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21019478
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.20527496
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18408683
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18366423
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17929942
80BCAT_22108803_ChIP-Seq_LS180_Human1.17580076
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17172870
82NANOG_19829295_ChIP-Seq_ESCs_Human1.17136712
83SOX2_19829295_ChIP-Seq_ESCs_Human1.17136712
84AR_25329375_ChIP-Seq_VCAP_Human1.16432795
85TAF2_19829295_ChIP-Seq_ESCs_Human1.16395375
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16149136
87OCT4_20526341_ChIP-Seq_ESCs_Human1.15759611
88RNF2_27304074_Chip-Seq_NSC_Mouse1.14598882
89HOXB7_26014856_ChIP-Seq_BT474_Human1.13960080
90* VDR_23849224_ChIP-Seq_CD4+_Human1.13365158
91DROSHA_22980978_ChIP-Seq_HELA_Human1.13228863
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12798999
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.12798999
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12391487
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11455605
96MYC_19829295_ChIP-Seq_ESCs_Human1.09846241
97P53_21459846_ChIP-Seq_SAOS-2_Human1.09365296
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09221061
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08496473
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07726997
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06125050
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05559511
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.04988493
104HTT_18923047_ChIP-ChIP_STHdh_Human1.03899928
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03482615
106RUNX2_22187159_ChIP-Seq_PCA_Human1.03361150
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02762954
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02725643
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02120710
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.01900660
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00518536
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00128742
113AR_21572438_ChIP-Seq_LNCaP_Human0.99921733
114SMAD4_21799915_ChIP-Seq_A2780_Human0.99725390
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98992549
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.98947381
117GATA4_25053715_ChIP-Seq_YYC3_Human0.98409235
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98084082
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97412235
120FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97001515
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96828120
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96795540
123RAC3_21632823_ChIP-Seq_H3396_Human0.96787509
124GATA1_19941826_ChIP-Seq_K562_Human0.96136310
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96126414
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96104230
127ETV1_20927104_ChIP-Seq_GIST48_Human0.95335078
128FOXP3_21729870_ChIP-Seq_TREG_Human0.94663745
129WDR5_24793694_ChIP-Seq_LNCAP_Human0.93971279
130TCF4_22108803_ChIP-Seq_LS180_Human0.91839764
131LXR_22292898_ChIP-Seq_THP-1_Human0.90794589
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89728436
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88445481
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86666655
135SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84073918
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81157452
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80895073
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80049843
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.78669353
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77389065
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76935665
142ZNF263_19887448_ChIP-Seq_K562_Human0.76752218
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76449056
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75120753
145ESR2_21235772_ChIP-Seq_MCF-7_Human0.74609212
146IRF8_27001747_Chip-Seq_BMDM_Mouse0.73412637
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72504696
148SCL_19346495_ChIP-Seq_HPC-7_Human0.72288788
149* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71631235
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71436833
151ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71060260
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70433968
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.70302490
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69167668
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.69101771
156* GATA2_19941826_ChIP-Seq_K562_Human0.68601715
157GATA6_25053715_ChIP-Seq_YYC3_Human0.68591300
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.66317378
159TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65506893
160* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64992042
161FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64906637
162FOXA1_25552417_ChIP-Seq_VCAP_Human0.62941660
163CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62113356
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61720719
165MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61542828
166FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60760394
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60276365
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59193067
169GATA2_21666600_ChIP-Seq_HMVEC_Human0.57977621
170RACK7_27058665_Chip-Seq_MCF-7_Human0.57909639
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.57604737
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56489448
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56295845
174* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56014281
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.55800733
176GATA2_22383799_ChIP-Seq_G1ME_Mouse0.55005448
177BCOR_27268052_Chip-Seq_Bcells_Human0.54816654
178MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.54352733
179AUTS2_25519132_ChIP-Seq_293T-REX_Human0.54325011
180EGR1_19032775_ChIP-ChIP_M12_Human0.53134056
181CEBPB_22108803_ChIP-Seq_LS180_Human0.52785567
182PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51832980
183AR_20517297_ChIP-Seq_VCAP_Human0.51460416
184NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51201705
185CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51082252
186TBX20_22080862_ChIP-Seq_HEART_Mouse0.49876431
187TBX20_22328084_ChIP-Seq_HEART_Mouse0.49876431
188ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.49365492
189TET1_21451524_ChIP-Seq_MESCs_Mouse0.48445009
190IRF8_21731497_ChIP-ChIP_J774_Mouse0.46265937
191CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46245188
192ESET_19884257_ChIP-Seq_ESCs_Mouse0.46225192
193SALL4_18804426_ChIP-ChIP_XEN_Mouse0.46094483
194MAF_26560356_Chip-Seq_TH1_Human0.45977461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.67549519
2MP0005360_urolithiasis6.95974717
3MP0005085_abnormal_gallbladder_physiolo5.75564726
4MP0005365_abnormal_bile_salt5.58841539
5MP0008875_abnormal_xenobiotic_pharmacok4.49544144
6MP0003252_abnormal_bile_duct3.86860671
7MP0003806_abnormal_nucleotide_metabolis3.70152317
8MP0003195_calcinosis3.33565061
9MP0009840_abnormal_foam_cell3.24087377
10MP0010329_abnormal_lipoprotein_level3.23313324
11MP0006292_abnormal_olfactory_placode3.11973798
12MP0008877_abnormal_DNA_methylation3.00818870
13MP0005332_abnormal_amino_acid2.78595576
14MP0005083_abnormal_biliary_tract2.70145347
15MP0001666_abnormal_nutrient_absorption2.60241063
16MP0002138_abnormal_hepatobiliary_system2.58092829
17MP0003646_muscle_fatigue2.41759269
18MP0005410_abnormal_fertilization2.40719113
19MP0003191_abnormal_cellular_cholesterol2.32398114
20MP0000609_abnormal_liver_physiology2.20487240
21MP0004019_abnormal_vitamin_homeostasis2.18979669
22MP0005551_abnormal_eye_electrophysiolog2.14937372
23MP0001485_abnormal_pinna_reflex2.10676151
24MP0002118_abnormal_lipid_homeostasis2.07146730
25MP0005646_abnormal_pituitary_gland2.06126838
26MP0001968_abnormal_touch/_nociception2.04590602
27MP0008872_abnormal_physiological_respon2.04169571
28MP0002102_abnormal_ear_morphology1.99489820
29MP0000569_abnormal_digit_pigmentation1.96703895
30MP0003868_abnormal_feces_composition1.95148736
31MP0005377_hearing/vestibular/ear_phenot1.91604579
32MP0003878_abnormal_ear_physiology1.91604579
33MP0003718_maternal_effect1.82495959
34MP0005319_abnormal_enzyme/_coenzyme1.76099868
35MP0009643_abnormal_urine_homeostasis1.76089122
36MP0005174_abnormal_tail_pigmentation1.72198189
37MP0009745_abnormal_behavioral_response1.71684981
38MP0006072_abnormal_retinal_apoptosis1.65635336
39MP0009046_muscle_twitch1.63072753
40MP0004133_heterotaxia1.62243830
41MP0001764_abnormal_homeostasis1.60689984
42MP0003693_abnormal_embryo_hatching1.57839253
43MP0005584_abnormal_enzyme/coenzyme_acti1.57765575
44MP0004142_abnormal_muscle_tone1.52456872
45MP0000631_abnormal_neuroendocrine_gland1.48558753
46MP0002736_abnormal_nociception_after1.48064506
47MP0002160_abnormal_reproductive_system1.48028182
48MP0003698_abnormal_male_reproductive1.47316265
49MP0003283_abnormal_digestive_organ1.47301126
50MP0001986_abnormal_taste_sensitivity1.46136564
51MP0003787_abnormal_imprinting1.45177822
52MP0002735_abnormal_chemical_nociception1.43716098
53MP0002938_white_spotting1.41728245
54MP0003136_yellow_coat_color1.40678774
55MP0008057_abnormal_DNA_replication1.39871592
56MP0005645_abnormal_hypothalamus_physiol1.39751142
57MP0005389_reproductive_system_phenotype1.39526559
58MP0005253_abnormal_eye_physiology1.38159431
59MP0002272_abnormal_nervous_system1.37822594
60MP0003119_abnormal_digestive_system1.37597039
61MP0010094_abnormal_chromosome_stability1.36752146
62MP0003186_abnormal_redox_activity1.36105884
63MP0004043_abnormal_pH_regulation1.35840386
64MP0001929_abnormal_gametogenesis1.35774944
65MP0002638_abnormal_pupillary_reflex1.33061166
66MP0008058_abnormal_DNA_repair1.31867236
67MP0003656_abnormal_erythrocyte_physiolo1.31378372
68MP0005636_abnormal_mineral_homeostasis1.28356166
69MP0002163_abnormal_gland_morphology1.25914908
70MP0000598_abnormal_liver_morphology1.23943342
71MP0005058_abnormal_lysosome_morphology1.22261897
72MP0000049_abnormal_middle_ear1.21584768
73MP0002653_abnormal_ependyma_morphology1.20260387
74MP0005408_hypopigmentation1.19800711
75MP0005451_abnormal_body_composition1.19193254
76MP0004885_abnormal_endolymph1.18358653
77MP0002078_abnormal_glucose_homeostasis1.17864668
78MP0002210_abnormal_sex_determination1.17169639
79MP0001501_abnormal_sleep_pattern1.17047564
80MP0001919_abnormal_reproductive_system1.16035780
81MP0005220_abnormal_exocrine_pancreas1.15926077
82MP0003705_abnormal_hypodermis_morpholog1.15356198
83MP0001905_abnormal_dopamine_level1.13314796
84MP0002234_abnormal_pharynx_morphology1.12674009
85MP0002733_abnormal_thermal_nociception1.11667853
86MP0001486_abnormal_startle_reflex1.10790979
87MP0009697_abnormal_copulation1.07442160
88MP0006276_abnormal_autonomic_nervous1.07298912
89MP0008469_abnormal_protein_level1.06557436
90MP0001293_anophthalmia1.06547925
91MP0001873_stomach_inflammation1.06480057
92MP0003300_gastrointestinal_ulcer1.04845705
93MP0000372_irregular_coat_pigmentation1.02741080
94MP0002064_seizures1.02253684
95MP0009764_decreased_sensitivity_to1.01253339
96MP0004147_increased_porphyrin_level1.00666240
97MP0009642_abnormal_blood_homeostasis0.99750704
98MP0000653_abnormal_sex_gland0.99576045
99MP0002557_abnormal_social/conspecific_i0.99184213
100MP0001756_abnormal_urination0.98359152
101MP0001145_abnormal_male_reproductive0.98123689
102MP0000604_amyloidosis0.97715276
103MP0005379_endocrine/exocrine_gland_phen0.97153519
104MP0009763_increased_sensitivity_to0.96306073
105MP0004742_abnormal_vestibular_system0.95397552
106MP0004145_abnormal_muscle_electrophysio0.95338563
107MP0001970_abnormal_pain_threshold0.95028806
108MP0005195_abnormal_posterior_eye0.94445712
109MP0001188_hyperpigmentation0.93277472
110MP0002572_abnormal_emotion/affect_behav0.93224078
111MP0002693_abnormal_pancreas_physiology0.92474955
112MP0002254_reproductive_system_inflammat0.91942617
113MP0003937_abnormal_limbs/digits/tail_de0.91801797
114MP0002928_abnormal_bile_duct0.91762786
115MP0003011_delayed_dark_adaptation0.89551183
116MP0001944_abnormal_pancreas_morphology0.89499697
117MP0006036_abnormal_mitochondrial_physio0.88974505
118MP0002095_abnormal_skin_pigmentation0.88475520
119MP0000427_abnormal_hair_cycle0.87559744
120MP0005647_abnormal_sex_gland0.87310756
121MP0002877_abnormal_melanocyte_morpholog0.87124769
122MP0005464_abnormal_platelet_physiology0.86695829
123MP0003172_abnormal_lysosome_physiology0.85607933
124MP0002876_abnormal_thyroid_physiology0.84156435
125MP0000015_abnormal_ear_pigmentation0.83947768
126MP0001963_abnormal_hearing_physiology0.83731169
127MP0008995_early_reproductive_senescence0.83632680
128MP0003786_premature_aging0.83015248
129MP0005670_abnormal_white_adipose0.81299183
130MP0004264_abnormal_extraembryonic_tissu0.80175235
131MP0005535_abnormal_body_temperature0.79947181
132MP0000026_abnormal_inner_ear0.79355379
133MP0005075_abnormal_melanosome_morpholog0.79299246
134MP0005334_abnormal_fat_pad0.77198878
135MP0002067_abnormal_sensory_capabilities0.76340781
136MP0002136_abnormal_kidney_physiology0.75597921
137MP0002971_abnormal_brown_adipose0.74967999
138MP0003890_abnormal_embryonic-extraembry0.74348255
139MP0009780_abnormal_chondrocyte_physiolo0.74101090
140MP0000470_abnormal_stomach_morphology0.73757232
141MP0002161_abnormal_fertility/fecundity0.73193475
142MP0003436_decreased_susceptibility_to0.73102764
143MP0002837_dystrophic_cardiac_calcinosis0.72548459
144MP0001324_abnormal_eye_pigmentation0.71425155
145MP0005376_homeostasis/metabolism_phenot0.69378745
146MP0009765_abnormal_xenobiotic_induced0.68619670
147MP0001765_abnormal_ion_homeostasis0.66463824
148MP0010368_abnormal_lymphatic_system0.63356806
149MP0004130_abnormal_muscle_cell0.62957502
150MP0003953_abnormal_hormone_level0.62728585
151MP0001661_extended_life_span0.62527638
152MP0005084_abnormal_gallbladder_morpholo0.61547903
153MP0006082_CNS_inflammation0.60099199
154MP0005448_abnormal_energy_balance0.59727180
155MP0001845_abnormal_inflammatory_respons0.57626594
156MP0005266_abnormal_metabolism0.56838960
157MP0000371_diluted_coat_color0.54855763
158MP0003724_increased_susceptibility_to0.53450127
159MP0009672_abnormal_birth_weight0.52188900
160MP0003690_abnormal_glial_cell0.49414294
161MP0000639_abnormal_adrenal_gland0.48845687
162MP0005666_abnormal_adipose_tissue0.47430336
163MP0003303_peritoneal_inflammation0.46588124
164MP0003075_altered_response_to0.46462600
165MP0002168_other_aberrant_phenotype0.45886646
166MP0002909_abnormal_adrenal_gland0.45221628
167MP0003638_abnormal_response/metabolism_0.44792441
168MP0000685_abnormal_immune_system0.43421708
169MP0003329_amyloid_beta_deposits0.42954970
170MP0002970_abnormal_white_adipose0.42767497
171MP0008961_abnormal_basal_metabolism0.42575145
172MP0005387_immune_system_phenotype0.41981885
173MP0001790_abnormal_immune_system0.41981885
174MP0001881_abnormal_mammary_gland0.41847623
175MP0008873_increased_physiological_sensi0.41617923
176MP0001835_abnormal_antigen_presentation0.41256931
177MP0005025_abnormal_response_to0.41242630
178MP0006035_abnormal_mitochondrial_morpho0.40399485
179MP0002419_abnormal_innate_immunity0.39984719
180MP0005395_other_phenotype0.37873302
181MP0002135_abnormal_kidney_morphology0.37163943
182MP0004947_skin_inflammation0.36661674

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.68977712
2Intrahepatic cholestasis (HP:0001406)6.50343272
3Deep venous thrombosis (HP:0002625)6.36606228
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98442689
5Xanthomatosis (HP:0000991)5.47360402
6Prolonged partial thromboplastin time (HP:0003645)5.45890772
7Hypobetalipoproteinemia (HP:0003563)5.09158696
8Hypoglycemic coma (HP:0001325)4.76969786
9Ketosis (HP:0001946)4.59225088
10Hyperlipoproteinemia (HP:0010980)4.57110994
11Joint hemorrhage (HP:0005261)4.39323452
12Complement deficiency (HP:0004431)4.28970588
13Ketoacidosis (HP:0001993)4.07308384
14Abnormality of the common coagulation pathway (HP:0010990)4.06659795
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06237078
16Pancreatic cysts (HP:0001737)4.00388485
17Hyperammonemia (HP:0001987)3.98572701
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.92484438
19Hypolipoproteinemia (HP:0010981)3.91401064
20Hypoglycemic seizures (HP:0002173)3.88172516
21Epidermoid cyst (HP:0200040)3.80609529
22Hyperglycinemia (HP:0002154)3.76162426
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75017395
24Abnormality of the intrinsic pathway (HP:0010989)3.73596635
25Congenital stationary night blindness (HP:0007642)3.71341461
26Fat malabsorption (HP:0002630)3.70370912
27Hyperglycinuria (HP:0003108)3.69752010
28Abnormality of methionine metabolism (HP:0010901)3.61233408
29Pancreatic fibrosis (HP:0100732)3.59219207
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56639658
31Abnormality of serine family amino acid metabolism (HP:0010894)3.53214970
32Abnormality of glycine metabolism (HP:0010895)3.53214970
33Hypoalphalipoproteinemia (HP:0003233)3.52472383
34Conjugated hyperbilirubinemia (HP:0002908)3.52417161
35Hyperinsulinemic hypoglycemia (HP:0000825)3.47702434
36Abnormality of midbrain morphology (HP:0002418)3.40880116
37Molar tooth sign on MRI (HP:0002419)3.40880116
38Pendular nystagmus (HP:0012043)3.37896839
39True hermaphroditism (HP:0010459)3.29677064
40Abnormality of pyrimidine metabolism (HP:0004353)3.23811168
41Nephronophthisis (HP:0000090)3.21040930
42Hyperbilirubinemia (HP:0002904)3.19724195
43Abnormality of fatty-acid metabolism (HP:0004359)3.18882918
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16199997
45Abnormality of nucleobase metabolism (HP:0010932)3.14233287
46Genetic anticipation (HP:0003743)3.13939400
47Abnormality of complement system (HP:0005339)3.11581536
48Abnormality of purine metabolism (HP:0004352)3.09444346
49Attenuation of retinal blood vessels (HP:0007843)3.08742427
50Late onset (HP:0003584)3.07317609
51Hypercholesterolemia (HP:0003124)3.01145242
52Gout (HP:0001997)2.98395064
53Chronic hepatic failure (HP:0100626)2.98122577
54Symptomatic seizures (HP:0011145)2.90300346
55Type II lissencephaly (HP:0007260)2.84497761
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83237047
57Abnormality of alanine metabolism (HP:0010916)2.83237047
58Hyperalaninemia (HP:0003348)2.83237047
59Abolished electroretinogram (ERG) (HP:0000550)2.80716046
60Abnormality of the renal cortex (HP:0011035)2.76350794
61Hepatocellular carcinoma (HP:0001402)2.74526531
62Steatorrhea (HP:0002570)2.69756833
63Abnormality of the renal medulla (HP:0100957)2.69299481
64Delayed CNS myelination (HP:0002188)2.69016867
65Myocardial infarction (HP:0001658)2.68441326
66Progressive cerebellar ataxia (HP:0002073)2.64344798
67Generalized aminoaciduria (HP:0002909)2.63459172
68Metabolic acidosis (HP:0001942)2.61698128
69Hypoplasia of the pons (HP:0012110)2.57923579
70Systemic lupus erythematosus (HP:0002725)2.57833691
71Skin nodule (HP:0200036)2.56599958
72Bony spicule pigmentary retinopathy (HP:0007737)2.56346482
73Abnormality of endocrine pancreas physiology (HP:0012093)2.54807558
74Abnormality of the pancreatic islet cells (HP:0006476)2.54807558
75Abnormality of the renal collecting system (HP:0004742)2.54699269
76Abnormality of serum amino acid levels (HP:0003112)2.51842973
77Dicarboxylic aciduria (HP:0003215)2.51137633
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51137633
79Sclerocornea (HP:0000647)2.49473255
80Cystic liver disease (HP:0006706)2.48117660
81Abnormality of the pons (HP:0007361)2.47985346
82Polydipsia (HP:0001959)2.45325420
83Abnormal drinking behavior (HP:0030082)2.45325420
84Hyperglycemia (HP:0003074)2.45054913
85Absent thumb (HP:0009777)2.44151224
86Vascular calcification (HP:0004934)2.42004939
87Severe visual impairment (HP:0001141)2.39915752
88Recurrent gram-negative bacterial infections (HP:0005420)2.39045817
89Mitral stenosis (HP:0001718)2.38642164
90Hypochromic microcytic anemia (HP:0004840)2.37025461
91Irritability (HP:0000737)2.36231428
92Gaze-evoked nystagmus (HP:0000640)2.35429808
93Abnormal gallbladder morphology (HP:0012437)2.34262060
94Aplasia/Hypoplasia of the patella (HP:0006498)2.32541171
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31650764
96Tubular atrophy (HP:0000092)2.28194563
97Acanthocytosis (HP:0001927)2.27949119
98Clumsiness (HP:0002312)2.27286962
99Patellar aplasia (HP:0006443)2.26911246
100Lethargy (HP:0001254)2.26471520
101Alkalosis (HP:0001948)2.25639111
102Duplicated collecting system (HP:0000081)2.25053992
103Abnormal rod and cone electroretinograms (HP:0008323)2.24274833
104Spastic diplegia (HP:0001264)2.23293524
105Menorrhagia (HP:0000132)2.21894227
106Cerebellar dysplasia (HP:0007033)2.21709269
107Inability to walk (HP:0002540)2.21418344
108Abnormality of DNA repair (HP:0003254)2.21196134
109Ectopic kidney (HP:0000086)2.20122279
110Pancreatitis (HP:0001733)2.20040632
111Cholelithiasis (HP:0001081)2.19865997
112Abnormal biliary tract physiology (HP:0012439)2.18098199
113Bile duct proliferation (HP:0001408)2.18098199
114Proximal tubulopathy (HP:0000114)2.17440930
115Spontaneous abortion (HP:0005268)2.17385786
116Abnormal enzyme/coenzyme activity (HP:0012379)2.17244561
117Pancreatic islet-cell hyperplasia (HP:0004510)2.16618055
118Aplasia/Hypoplasia of the uvula (HP:0010293)2.16330839
119Chorioretinal atrophy (HP:0000533)2.14936877
120Methylmalonic acidemia (HP:0002912)2.13848382
121Chromsome breakage (HP:0040012)2.12264154
122Esophageal varix (HP:0002040)2.12112219
123Sensorimotor neuropathy (HP:0007141)2.10716962
124Gingival bleeding (HP:0000225)2.10453013
125Glomerulonephritis (HP:0000099)2.10234042
126Decreased central vision (HP:0007663)2.10097445
127Abnormality of proline metabolism (HP:0010907)2.09866774
128Hydroxyprolinuria (HP:0003080)2.09866774
129Increased corneal curvature (HP:0100692)2.09661323
130Keratoconus (HP:0000563)2.09661323
131Methylmalonic aciduria (HP:0012120)2.09509907
132Congenital sensorineural hearing impairment (HP:0008527)2.09222529
133Enlarged kidneys (HP:0000105)2.08757412
134Congenital, generalized hypertrichosis (HP:0004540)2.08617788
135Abnormal gallbladder physiology (HP:0012438)2.08120394
136Cholecystitis (HP:0001082)2.08120394
137Cardiovascular calcification (HP:0011915)2.07914297
138Birth length less than 3rd percentile (HP:0003561)2.07539862
139Medial flaring of the eyebrow (HP:0010747)2.06960667
140Neonatal onset (HP:0003623)2.06322097
141Urinary glycosaminoglycan excretion (HP:0003541)2.05998384
142Mucopolysacchariduria (HP:0008155)2.05998384
143Absent/shortened dynein arms (HP:0200106)2.04020554
144Dynein arm defect of respiratory motile cilia (HP:0012255)2.04020554
145Protruding tongue (HP:0010808)2.03496203
146Abnormality of the ileum (HP:0001549)2.02640635
147Meckel diverticulum (HP:0002245)2.01101344
148Elevated alkaline phosphatase (HP:0003155)2.00885526
149Increased purine levels (HP:0004368)2.00789131
150Hyperuricemia (HP:0002149)2.00789131
151Malnutrition (HP:0004395)2.00588497
152Bilateral microphthalmos (HP:0007633)1.99940278
153Increased CSF lactate (HP:0002490)1.99672716
154Abnormality of urine glucose concentration (HP:0011016)1.99592676
155Glycosuria (HP:0003076)1.99592676
156Polyuria (HP:0000103)1.98936418
157Rickets (HP:0002748)1.98908455
158Mitochondrial inheritance (HP:0001427)1.98076242
159Large for gestational age (HP:0001520)1.97469444
160Abnormality of alkaline phosphatase activity (HP:0004379)1.97216617
161Vomiting (HP:0002013)1.95173814
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.94928173
163Renal cortical cysts (HP:0000803)1.93719844
164Severe muscular hypotonia (HP:0006829)1.93653595
165Anencephaly (HP:0002323)1.93401708
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92998209
167Male pseudohermaphroditism (HP:0000037)1.92897489
168Hyperventilation (HP:0002883)1.91452962
169Congenital hepatic fibrosis (HP:0002612)1.91146237
170Abnormality of transition element cation homeostasis (HP:0011030)1.90305013
171Cerebral edema (HP:0002181)1.89591045
172Decreased circulating renin level (HP:0003351)1.89466857
173Hemorrhage of the eye (HP:0011885)1.89425145
174Abnormality of the gallbladder (HP:0005264)1.89306344
175Acute necrotizing encephalopathy (HP:0006965)1.81556959
176Furrowed tongue (HP:0000221)1.80439771
177Progressive inability to walk (HP:0002505)1.79641755
178Sloping forehead (HP:0000340)1.79546379
179Small hand (HP:0200055)1.79008107
180Lissencephaly (HP:0001339)1.78810137
181IgG deficiency (HP:0004315)1.77410151
182Acute encephalopathy (HP:0006846)1.72159995
183Retinal dysplasia (HP:0007973)1.69332950
184Short thumb (HP:0009778)1.68610458
185Lipid accumulation in hepatocytes (HP:0006561)1.68430706
186Abnormal number of erythroid precursors (HP:0012131)1.68033755
187Abnormal urine output (HP:0012590)1.67529201
188Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67361817
189Hepatocellular necrosis (HP:0001404)1.67327652
190Increased serum lactate (HP:0002151)1.65973105
191Colon cancer (HP:0003003)1.65731395
192Aplasia/Hypoplasia of the tongue (HP:0010295)1.64978632
193Clubbing of toes (HP:0100760)1.63514628
194Short hallux (HP:0010109)1.62380245
195Abnormal mitochondria in muscle tissue (HP:0008316)1.62146447
196Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61232855
197Abnormality of homocysteine metabolism (HP:0010919)1.61104831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.19468580
2ERN14.23700420
3TRIB34.17168234
4INSRR3.86833468
5PKN23.79478989
6ZAK3.78898779
7TAOK33.76900073
8SIK13.57003771
9ADRBK23.41200733
10FGFR43.29067391
11BMPR1B3.19642551
12GRK12.87919439
13NUAK12.77990153
14ACVR1B2.59511305
15MAP4K22.49215219
16FLT32.18510350
17MST1R2.18057618
18PTK62.16376602
19CDC71.86826724
20PLK41.84203784
21TYK21.80732455
22WNK41.76718525
23TBK11.75050261
24SIK21.72935592
25VRK21.72062435
26MAP4K11.56305865
27TXK1.50532556
28IRAK31.45828397
29VRK11.42884387
30FRK1.42376317
31MKNK21.37889362
32OXSR11.36186439
33MAP3K141.35431176
34MAP3K101.33175494
35ERBB41.32518857
36JAK11.31902096
37BUB11.31002688
38STK161.25658539
39MAPK111.23945681
40JAK21.21755164
41MAPK151.20993598
42NEK21.17056606
43PNCK1.16731878
44MAPK131.16635207
45TAF11.16573153
46DYRK21.15333813
47DYRK1B1.13697315
48TNIK1.13302757
49HIPK21.12180963
50EPHB11.11940383
51GRK61.10448179
52STK391.06551850
53CHEK21.04779622
54PIK3CG1.04711288
55ATR0.99330165
56MAPKAPK50.98981267
57PASK0.98678775
58ADRBK10.98542989
59KDR0.97215811
60PRKCG0.96675451
61JAK30.93570863
62MET0.92612182
63LATS10.92032186
64NME10.91103852
65NEK90.89034794
66PRKAA20.88636174
67MAP3K30.86528647
68TGFBR10.85857850
69MAP2K30.84958864
70NTRK30.84802855
71MARK30.84456147
72MUSK0.84389045
73CSK0.83124302
74IKBKE0.82838105
75PLK10.81522396
76EPHA30.80959038
77GSK3A0.80645081
78MAP2K40.80526728
79CSNK1G10.75262342
80ZAP700.73708089
81STK38L0.73246940
82PRKAA10.73042592
83CAMK1G0.72009598
84PTK20.71605996
85RPS6KA50.71133441
86CSNK1G30.70555414
87MAP3K70.70552417
88FGFR30.70041113
89LRRK20.69832063
90CDK60.69213437
91MAP3K110.68714366
92MAP3K40.68092559
93BTK0.67606725
94MAP3K10.67398489
95RET0.66451438
96MAP3K20.65524702
97BRSK20.65408443
98TEC0.64970865
99PRKCE0.64299605
100CAMK1D0.63908589
101PLK20.62562238
102CSNK1A1L0.61930333
103WNK30.60744114
104CSNK1G20.60411616
105RIPK10.60083178
106CSF1R0.59979301
107TLK10.59741605
108ITK0.59706379
109PDPK10.58689748
110PLK30.57886992
111ABL20.57574010
112TRIM280.57317631
113KIT0.56174334
114PRKACG0.54524163
115BMX0.54337353
116TGFBR20.53551005
117PRKCZ0.53454281
118TNK20.53392043
119MKNK10.52343627
120SGK30.52183483
121PDK10.51336340
122MAP2K60.50001659
123AURKA0.49967200
124PIK3CA0.49870717
125MAP2K20.48964227
126CDK80.48934474
127DAPK20.48742227
128PRKCI0.47796583
129PRKCQ0.47442853
130ATM0.46592402
131TIE10.46431766
132CSNK1A10.45421957
133PRKCH0.45284103
134CHUK0.45028909
135SYK0.43723885
136NLK0.43253142
137PRKACA0.42859741
138PINK10.41866070
139RPS6KA60.41602263
140CSNK1D0.41388799
141CAMK10.41042431
142MAPKAPK30.40860951
143CDK120.40716293
144MTOR0.40583870
145MAPK40.39950127
146SRPK10.39571414
147IRAK40.39401055
148CAMKK20.38748087
149IGF1R0.38663124
150PKN10.38274071
151CASK0.37844314
152TTK0.37735069
153SCYL20.37577986
154PTK2B0.37309887
155STK110.37155645
156WEE10.36661821
157MAP2K10.36334315
158PAK30.36121093
159MAP2K70.35787039
160ICK0.32979617
161FGFR20.32662931
162CDK190.32547004
163ERBB20.32302892
164CAMKK10.31151012
165IKBKB0.30821112
166PIM10.29763871
167EGFR0.29335000
168CDK40.28902063
169PRKD10.28583162
170STK30.28390224
171BLK0.28011809
172MAP3K60.27242625
173LYN0.26665469

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06013862
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34487469
3Nitrogen metabolism_Homo sapiens_hsa009103.29796082
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28501615
5Arginine biosynthesis_Homo sapiens_hsa002202.86864644
6Tryptophan metabolism_Homo sapiens_hsa003802.75931691
7Homologous recombination_Homo sapiens_hsa034402.71887501
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62959068
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.61132176
10Fatty acid degradation_Homo sapiens_hsa000712.49873602
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49814533
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48794207
13Complement and coagulation cascades_Homo sapiens_hsa046102.47628347
14Phototransduction_Homo sapiens_hsa047442.41611892
15RNA polymerase_Homo sapiens_hsa030202.38518515
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38083515
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32800811
18Butanoate metabolism_Homo sapiens_hsa006502.12855314
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12359887
20Peroxisome_Homo sapiens_hsa041462.05919561
21Fanconi anemia pathway_Homo sapiens_hsa034602.04022151
22Propanoate metabolism_Homo sapiens_hsa006401.97962533
23Histidine metabolism_Homo sapiens_hsa003401.87042725
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86233494
25Nicotine addiction_Homo sapiens_hsa050331.85371994
26Sulfur metabolism_Homo sapiens_hsa009201.84264611
27* Selenocompound metabolism_Homo sapiens_hsa004501.78560968
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77301637
29PPAR signaling pathway_Homo sapiens_hsa033201.75932779
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75571547
31Fatty acid metabolism_Homo sapiens_hsa012121.74961513
32Oxidative phosphorylation_Homo sapiens_hsa001901.74938160
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73757393
34Staphylococcus aureus infection_Homo sapiens_hsa051501.67813430
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.67434832
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65378451
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64840367
38Chemical carcinogenesis_Homo sapiens_hsa052041.63627830
39beta-Alanine metabolism_Homo sapiens_hsa004101.63552547
40Caffeine metabolism_Homo sapiens_hsa002321.62176652
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60176800
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.58502339
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56464147
44Phenylalanine metabolism_Homo sapiens_hsa003601.53841290
45Basal transcription factors_Homo sapiens_hsa030221.52811174
46Starch and sucrose metabolism_Homo sapiens_hsa005001.47332066
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44958867
48Bile secretion_Homo sapiens_hsa049761.44778712
49Taste transduction_Homo sapiens_hsa047421.44361074
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42680185
51Tyrosine metabolism_Homo sapiens_hsa003501.41334255
52Pyruvate metabolism_Homo sapiens_hsa006201.39675653
53ABC transporters_Homo sapiens_hsa020101.39550225
54Retinol metabolism_Homo sapiens_hsa008301.38864677
55Parkinsons disease_Homo sapiens_hsa050121.37237252
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34387771
57Primary immunodeficiency_Homo sapiens_hsa053401.33613090
58RNA degradation_Homo sapiens_hsa030181.30993667
59Folate biosynthesis_Homo sapiens_hsa007901.28355355
60Ether lipid metabolism_Homo sapiens_hsa005651.25759156
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24400303
62Olfactory transduction_Homo sapiens_hsa047401.21659340
63Morphine addiction_Homo sapiens_hsa050321.21633405
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.19951177
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.19255125
66Fat digestion and absorption_Homo sapiens_hsa049751.18409898
67Pyrimidine metabolism_Homo sapiens_hsa002401.17688566
68Carbon metabolism_Homo sapiens_hsa012001.17597719
69DNA replication_Homo sapiens_hsa030301.17360183
70Biosynthesis of amino acids_Homo sapiens_hsa012301.15946036
71Huntingtons disease_Homo sapiens_hsa050161.15787888
72Fatty acid elongation_Homo sapiens_hsa000621.12695550
73Cyanoamino acid metabolism_Homo sapiens_hsa004601.08517728
74Purine metabolism_Homo sapiens_hsa002301.02684749
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01643718
76Vitamin digestion and absorption_Homo sapiens_hsa049770.98266831
77Lysine degradation_Homo sapiens_hsa003100.98175495
78Arginine and proline metabolism_Homo sapiens_hsa003300.97985304
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97115099
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96863099
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96660959
82Mismatch repair_Homo sapiens_hsa034300.96220439
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95982505
84Ribosome_Homo sapiens_hsa030100.95895655
85Steroid biosynthesis_Homo sapiens_hsa001000.93590052
86Base excision repair_Homo sapiens_hsa034100.91479256
87Arachidonic acid metabolism_Homo sapiens_hsa005900.88885437
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86144009
89One carbon pool by folate_Homo sapiens_hsa006700.85617379
90Alzheimers disease_Homo sapiens_hsa050100.85603150
91Non-homologous end-joining_Homo sapiens_hsa034500.84637860
92Nucleotide excision repair_Homo sapiens_hsa034200.83338109
93Cardiac muscle contraction_Homo sapiens_hsa042600.82760057
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81914785
95Serotonergic synapse_Homo sapiens_hsa047260.80678396
96Sulfur relay system_Homo sapiens_hsa041220.78421389
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76771898
98RNA transport_Homo sapiens_hsa030130.76190485
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69371424
100GABAergic synapse_Homo sapiens_hsa047270.68579950
101Glycerolipid metabolism_Homo sapiens_hsa005610.66250715
102Vitamin B6 metabolism_Homo sapiens_hsa007500.63886228
103Circadian entrainment_Homo sapiens_hsa047130.62366306
104Pentose phosphate pathway_Homo sapiens_hsa000300.60727090
105Glutamatergic synapse_Homo sapiens_hsa047240.59807153
106Insulin secretion_Homo sapiens_hsa049110.58204645
107Proteasome_Homo sapiens_hsa030500.56512060
108Glutathione metabolism_Homo sapiens_hsa004800.56097010
109Calcium signaling pathway_Homo sapiens_hsa040200.55667300
110Asthma_Homo sapiens_hsa053100.53212601
111Galactose metabolism_Homo sapiens_hsa000520.48823485
112Insulin resistance_Homo sapiens_hsa049310.47557173
113Fructose and mannose metabolism_Homo sapiens_hsa000510.43427438
114Ovarian steroidogenesis_Homo sapiens_hsa049130.43061294
115* Metabolic pathways_Homo sapiens_hsa011000.42920956
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.42015176
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.40772119
118Spliceosome_Homo sapiens_hsa030400.37839625
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35564542
120Type I diabetes mellitus_Homo sapiens_hsa049400.35305502
121Fatty acid biosynthesis_Homo sapiens_hsa000610.33843091
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32588126
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31695767
124Prion diseases_Homo sapiens_hsa050200.27518288
125Lysosome_Homo sapiens_hsa041420.24275352
126Glucagon signaling pathway_Homo sapiens_hsa049220.23964203
127Linoleic acid metabolism_Homo sapiens_hsa005910.21064506
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17718000
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15381788
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.12782485
131AMPK signaling pathway_Homo sapiens_hsa041520.12674164
132Other glycan degradation_Homo sapiens_hsa005110.12185535
133Type II diabetes mellitus_Homo sapiens_hsa049300.10256350
134Protein export_Homo sapiens_hsa030600.02321084
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.00621509
136Regulation of autophagy_Homo sapiens_hsa04140-0.1715110
137NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1700417
138Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1608815
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1607499
140Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1406379
141N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1099487
142Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1069189
143Renin-angiotensin system_Homo sapiens_hsa04614-0.0913848
144Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0780605
145Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0721669
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0698903
147Hepatitis C_Homo sapiens_hsa05160-0.0693041
148Insulin signaling pathway_Homo sapiens_hsa04910-0.0087780

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